category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	81/514	222/9376	6.65558944158166	RPL29/RPS18/RPS4X/RPS6/RPL18A/RPL6/RPLP0/RPL37/RPL36/RPS19/RPL39/RPS3A/RPSA/RPL11/RPS5/RPS15/RPL7A/RPS11/RPS12/RPL8/RPS26/RPS7/RPLP1/RPL32/RPS2/RPL13/RPS13/RPS27A/RPS16/RPL12/RPS3/RPL10A/RPL22/RPL26/RPS24/RPS27/RPL35/RPL15/RPL14/RPL5/UBA52/RPL28/RPL37A/RPL21/RPL3/RPL18/RPL24/RPS9/RPL34/RPS14/RPL13A/RPLP2/RPL23A/RPS8/RPS29/RPL19/RPL10/RPL9/RPL27A/RPL35A/RPL38/RPL27/RPL4/MRPS15/RPS28/MRPL11/RPS23/MRPL23/RPS10/RPS25/MRPL52/RPL17/RPL22L1/RPL7/MRPL41/MRPL51/RPS21/MRPL12/MRPL35/MRPS16/MRPL20	20.5376256297238
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	75/514	238/9376	5.74829153451264	RPL29/RPS18/RPS4X/RPS6/RPL18A/RPL6/RPLP0/RPL37/RPL36/RPS19/RPL39/RPS3A/RPSA/RPL11/RPS5/RPS15/RPL7A/RPS11/RPS12/RPL8/RPS26/RPS7/RPLP1/CFD/RPL32/RPS2/RPL13/RPS13/RPS27A/RPS16/RPL12/RPS3/RPL10A/RPL22/RPL26/RPS24/RPS27/RPL35/RPL15/RPL14/RPL5/UBA52/RPL28/RPL37A/RPL21/RPL3/RPL18/RPL24/RPS9/RPL34/RPS14/ISG15/RPL13A/RPLP2/RPL23A/RPS8/RPS29/RPL19/RPL10/RPL9/RPL27A/RPL35A/RPL38/RPL27/RPL4/RPS28/RPS23/RPS10/RPS25/RPL17/RPL22L1/RPL7/RPS21/PIK3CB/C1R	17.8690556896714
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/514	268/9376	3.87966780881584	TUBA1C/TXN/RPS27A/CALM1/PSMA7/UBA52/UQCRH/TUBA1B/TUBB/NDUFA4/NDUFB2/HSPA5/COX5B/COX5A/NDUFS5/VDAC1/CALM3/TUBB4B/COX7B/COX6C/UBE2L3/NDUFC1/PARK7/NDUFA12/PSMB6/PSMB1/PSMA4/PSMB3/SLC25A5/UQCR10/COX8A/GNAS/TXN2/COX6B1/NDUFV2/NDUFA6/NDUFB3/TUBB6/PSMD2/UBC/COX7A2/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/PSMD14/NDUFV3/PSMB2/CYC1/NDUFB4/PSMA1/PSMC4	11.5185974907879
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	55/514	308/9376	3.25736520289049	TUBA1C/PSMA7/UQCRH/GPX3/TUBA1B/TUBB/NDUFA4/NDUFB2/PPARG/COX5B/COX5A/NDUFS5/VDAC1/TUBB4B/TGM2/COX7B/POLR2L/COX6C/POLR2F/NDUFC1/NDUFA12/PSMB6/PSMB1/PSMA4/PSMB3/SLC25A5/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/NDUFB3/TUBB6/POLR2J/PSMD2/COX7A2/POLR2H/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/POLR2I/PSMD14/NDUFV3/PSMB2/CYC1/NDUFB4/PSMA1/PSMC4/CLTA	9.70113958575253
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	51/514	275/9376	3.38292182525646	TUBA1C/PSMA7/UQCRH/TUBA1B/TUBB/NDUFA4/NDUFB2/HSPA8/HSPA5/COX5B/COX5A/NDUFS5/VDAC1/TUBB4B/COX7B/COX6C/NDUFC1/NDUFA12/PSMB6/PSMB1/PSMA4/PSMB3/SLC25A5/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/NDUFB3/TUBB6/PSMD2/COX7A2/PIK3CB/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/RAC1/PSMD14/NDUFV3/PSMB2/CYC1/NDUFB4/PSMA1/PSMC4/PPP3CA	9.65901653635052
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	57/514	368/9376	2.82541025207241	TUBA1C/PFN1/PSMA7/UQCRH/GPX3/TUBA1B/CHCHD10/TUBB/ACTB/NDUFA4/NDUFB2/HSPA5/HNRNPA1/COX5B/COX5A/NDUFS5/VDAC1/TUBB4B/COX7B/COX6C/SRSF3/NDUFC1/NDUFA12/PSMB6/PSMB1/PSMA4/PSMB3/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/NDUFB3/NUP37/TUBB6/PSMD2/COX7A2/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/ALYREF/NDUFC2/CYCS/COX8C/NDUFS8/HNRNPA3/RAC1/PSMD14/NDUFV3/PSMB2/CYC1/NDUFB4/PSMA1/PSMC4/PPP3CA	8.6034280438845
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	32/514	138/9376	4.22985394462302	UQCRH/PPA1/NDUFA4/NDUFB2/COX5B/COX5A/NDUFS5/COX7B/COX6C/NDUFC1/NDUFA12/UQCR10/COX8A/COX6B1/ATP6V1C2/NDUFV2/NDUFA6/NDUFB3/COX7A2/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/COX17/NDUFV3/CYC1/NDUFB4	9.20523272830544
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	34/514	157/9376	3.95033334159459	LEP/UQCRH/NDUFA4/NDUFB2/PPARG/COX5B/COX5A/NDUFS5/COX7B/COX6C/CDC42/NDUFC1/NDUFA12/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/NDUFB3/COX7A2/PIK3CB/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/RAC1/NDUFV3/CYC1/NDUFB4	8.97801508575529
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	56/514	388/9376	2.6327570299651	TUBA1C/GAPDH/CALM1/PSMA7/UQCRH/TUBA1B/TUBB/NDUFA4/NDUFB2/COX5B/COX5A/NDUFS5/VDAC1/CALM3/TUBB4B/CTNNB1/COX7B/COX6C/NDUFC1/HSD17B10/NDUFA12/PSMB6/PSMB1/PSMA4/PSMB3/SLC25A5/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/WNT7A/NDUFB3/TUBB6/DKK1/PSMD2/COX7A2/PIK3CB/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/APP/PSMD14/NDUFV3/PSMB2/CYC1/NDUFB4/PSMA1/PSMC4/PPP3CA	7.91055980288268
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/514	205/9376	3.38130397646389	GAPDH/UQCRH/MMP2/NDUFA4/NDUFB2/SLC2A1/COX5B/COX5A/PPP1CB/NDUFS5/VDAC1/COX7B/COX6C/NDUFC1/NDUFA12/SLC25A5/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/NDUFB3/PARP1/COX7A2/PIK3CB/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/COX8C/NDUFS8/PRKCZ/RAC1/NDUFV3/CYC1/NDUFB4	8.30203855327787
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	40/514	235/9376	3.10489278913817	RPS6/UQCRH/ACTB/NDUFA4/NDUFB2/PPARG/COX5B/COX5A/NDUFS5/GRB2/COX7B/COX6C/NDUFC1/NDUFA12/UQCR10/COX20/COX8A/GNAS/COX6B1/NDUFV2/NDUFA6/NDUFB3/COX7A2/NDUFA2/NDUFB1/COX16/COX7C/NDUFA11/NDUFS6/NDUFC2/COA4/COX8C/NDUFS8/COX17/NDUFV3/CYC1/NDUFB4/ACSL4/SMARCA2/ADCY1	7.86988492093619
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	62/514	480/9376	2.35616083009079	TUBA1C/RPS27A/CALM1/PSMA7/UBA52/UQCRH/GPX3/TUBA1B/TUBB/NDUFA4/NDUFB2/HSPA5/COX5B/COX5A/NDUFS5/VDAC1/CALM3/TUBB4B/CTNNB1/COX7B/COX6C/UBE2L3/NDUFC1/HSD17B10/PARK7/NDUFA12/PSMB6/PSMB1/PSMA4/PSMB3/SLC25A5/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/WNT7A/NDUFB3/TUBB6/DKK1/PSMD2/UBC/COX7A2/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/CYCS/COX8C/NDUFS8/APP/RAC1/PSMD14/NDUFV3/PSMB2/CYC1/NDUFB4/PSMA1/PSMC4/PPP3CA	7.3457433890307
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	36/514	227/9376	2.89288469120143	MGST3/UQCRH/MGST1/NDUFA4/NDUFB2/COX5B/COX5A/NDUFS5/VDAC1/GRB2/COX7B/COX6C/NDUFC1/NDUFA12/SLC25A5/UQCR10/COX8A/COX6B1/NDUFV2/NDUFA6/NDUFB3/COX7A2/PIK3CB/NDUFA2/NDUFB1/COX7C/NDUFA11/NDUFS6/NDUFC2/ACP1/COX8C/NDUFS8/RAC1/NDUFV3/CYC1/NDUFB4	6.95266971020042
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	20/514	116/9376	3.14504226485979	GAPDH/GCSH/ENO1/PKM/PRPS2/ACAT2/TKT/TPI1/TALDO1/GLDC/PFKP/PGP/PGAM1/ALDOA/PCCA/PGK1/ADH5/MDH2/IDH1/IDH2	5.59835816584443
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/514	46/9376	4.7585856877009	PSMA7/POMP/PSMB6/PSMB1/PSMA4/PSMB3/PSMD2/PSME2/PSMD14/PSMB2/PSMA1/PSMC4	6.15409044258055
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	23/514	158/9376	2.65537112741959	CCNE1/CCNB1/CDKN1C/PTTG1/YWHAE/CDK7/ANAPC11/CCNB2/SKP2/MAD2L1/WEE1/CDC20/CDK1/YWHAB/AURKB/CHEK1/CCNA2/SMC1A/DBF4/YWHAG/MCM7/RBX1/ANAPC15	5.05367015154341
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	16/514	87/9376	3.35471174918377	TPM1/UQCRH/COX5B/COX5A/TPM2/COX7B/COX6C/TPM3/UQCR10/COX8A/COX6B1/COX7A2/COX7C/COX8C/MYL4/CYC1	5.31391031660568
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/514	138/9376	2.77584165115886	CCNE1/CCNB1/CALM1/PTTG1/YWHAE/PPP1CB/IGF1/CALM3/ANAPC11/CCNB2/MAD2L1/AURKA/CDC20/CDK1/YWHAB/SMC1A/YWHAG/RBX1/PPP3CA/ANAPC15/ADCY1	5.06123062151142
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	24/514	174/9376	2.51603381188783	CALR/PDIA6/SSR4/HSPA8/HSPA5/PDIA4/SSR3/MAN1A2/TUSC3/ERP29/RPN2/LMAN2/SEC61G/P4HB/PDIA3/LMAN1/EDEM2/OSTC/RBX1/HSP90B1/STT3A/STT3B/SEC61B/DNAJB11	4.86120260477639
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/514	75/9376	3.40503242542153	GAPDH/ENO1/PKM/PRPS2/TKT/TPI1/TALDO1/PFKP/PGAM1/ALDOA/PGK1/ARG2/IDH1/IDH2	5.03602723829987
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/514	59/9376	3.71008375651256	MGST3/PRDX6/GPX3/MGST1/GSTP1/RRM2/SRM/GGCT/SMS/GPX4/IDH1/IDH2	5.02888837846605
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	24/514	200/9376	2.18894941634241	TUBA1C/GAPDH/RPS3/TUBA1B/CLDN7/TUBB/ACTB/EZR/CLDN4/TUBB4B/TMBIM6/ARPC3/CDC42/CLDN10/NCL/TMED10/ARPC1B/ARPC2/TUBB6/ARPC5/ARPC4/CLDN19/CYCS/RAC1	4.09310606084477
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/514	170/9376	2.25333028152895	TUBA1C/TUBA1B/CLDN7/ACTB/EZR/CLDN4/MYL6/ARPC3/CDC42/CLDN10/ARPC1B/ARPC2/ARPC5/F11R/ARPC4/TIAM1/MYL12B/CLDN19/ACTN1/PRKCZ/RAC1	3.97151157810336
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/514	116/9376	2.51603381188783	MMP2/CLDN7/ACTB/EZR/CLDN4/CTNNB1/CDC42/THY1/CLDN10/CDH5/F11R/PIK3CB/MYL12B/CLDN19/ACTN1/RAC1	3.95670538036381
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/514	142/9376	2.31227051022086	TXN/MGST3/CALM1/MMP2/MGST1/ACTB/GSTP1/CALM3/CTNNB1/CTSL/RAC3/TXN2/SDC4/CDH5/PIK3CB/PRKCZ/RAC1/HSP90B1	3.79466927836613
Genetic Information Processing	Transcription	hsa03040	Spliceosome	26/514	243/9376	1.95173816271957	SNRPD1/RBM8A/LSM4/SNRPF/HSPA8/HNRNPA1/SNRPG/SNRPB/SNRPD2/LSM3/LSM7/SRSF3/LSM5/SRSF2/HNRNPM/SNRPE/LSM2/THOC7/HNRNPC/ALYREF/SNRPD3/HNRNPK/HNRNPA3/SNRPA1/U2AF1/TXNL4A	3.62005539935756
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/514	67/9376	2.99483129101574	GAPDH/ENO1/LDHB/PKM/LDHA/TPI1/PFKP/PGAM1/ALDOA/PGK1/ADH5	3.94632985465012
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/514	78/9376	2.8063454055672	ACTB/ITGA5/CTNNB1/ARPC3/CDC42/ARPC1B/ARPC2/ARPC5/PIK3CB/ARPC4/RAC1/CLTA	3.85793276019083
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/514	31/9376	4.11899083720346	HSPA5/SEC11A/SPCS3/SEC11C/SEC61G/SRP14/SEC61B	4.18896390138949
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/514	85/9376	2.57523460746166	RRM2/NME1/AK5/APRT/TK1/DTYMK/ADK/GUK1/PNP/HDDC2/DUT/IMPDH2	3.51337739098408
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	25/514	248/9376	1.83883519518012	TUBA1C/GAPDH/TXN/PFN1/RPS3/TUBA1B/TUBB/ACTB/TUBB4B/CTNNB1/ARPC3/CDC42/DYNLL1/TXN2/ARPC1B/ARPC2/TCF7L2/TUBB6/ARPC5/PIK3CB/ARPC4/MYL12B/CYCS/RAC1/HSP90B1	3.22415560387658
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/514	75/9376	2.67538261997406	CCNE1/CCNB1/PERP/RRM2/IGF1/CCNB2/RPRM/CDK1/SIVA1/CHEK1/CYCS	3.50817411839458
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	17/514	149/9376	2.08121588802131	NDUFA4/NDUFB2/NDUFS5/NDUFC1/NDUFA12/NDUFV2/NDUFA6/NDUFB3/NDUFA2/NDUFB1/NDUFA11/NDUFS6/NDUFC2/NDUFS8/NDUFV3/NDUFB4/ADCY1	3.20388277534588
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/514	71/9376	2.56918945580095	SLC16A3/LDHB/SLC2A1/PKM/LDHA/PFKP/PGAM1/PIK3CB/IDH1/IDH2	3.19630115473748
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/514	224/9376	1.79155086158977	HLA-G/CCNE1/CALR/RAN/RANBP1/PTTG1/SLC2A1/VDAC1/ANAPC11/FDPS/CCNB2/MAD2L1/CDC20/SLC25A5/PIK3CB/CHEK1/CCNA2/NFYB/IL15/PPP3CA/ANAPC15/ADCY1	2.88766064636844
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/514	31/9376	3.53056357474583	GCSH/ACAT2/GLDC/PGP/PCCA/MDH2	3.39867605199056
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/514	52/9376	2.8063454055672	CGA/CYP11A1/IGF1/HSD3B1/GNAS/LDLR/CYP19A1/ADCY1	3.14559396575169
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/514	23/9376	3.96548807308408	FDPS/HMGCS1/ACAT2/IDI1/HMGCR	3.42914585195417
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/514	44/9376	2.90201627166608	B4GALT1/MAN1A2/TUSC3/RPN2/OSTC/STT3A/STT3B	3.04547140434295
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/514	93/9376	2.15756662901134	ACTB/CTNNB1/CDC42/RAC3/CDH5/TCF7L2/PTPRF/MYL12B/ACP1/ACTN1/RAC1	2.70174665287164
NA	NA	hsa04517	IgSF CAM signaling	26/514	299/9376	1.58619522923363	TUBA1C/TUBA1B/TUBB/ACTB/EZR/GRB2/ITGA5/TUBB4B/CTNNB1/MYL6/ARPC3/CDC42/DYNLL1/ARPC1B/ARPC2/TUBB6/ARPC5/PTPRF/F11R/PTPRS/PIK3CB/ARPC4/MYL12B/ACTN1/APP/RAC1	2.48089298385003
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/514	110/9376	1.98995401485674	RPS6/GAPDH/ENO1/LDHB/SLC2A1/IGF1/LDHA/PFKP/ALDOA/PGK1/PIK3CB/RBX1	2.51516534669433
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/514	63/9376	2.31634858872213	CDK7/POLR2L/POLR2F/RPA3/POLR2J/POLR2H/POLR2I/RBX1	2.52462983524262
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/514	253/9376	1.58619522923363	RPS27A/PFN1/UBA52/ACTB/VDAC1/BNIP3/ITGA5/ARPC3/CDC42/CBX3/ARPC1B/ARPC2/ARPC5/UBC/PIK3CB/ARPC4/MYL12B/ACTN1/CYCS/RBX1/RAC1/U2AF1	2.27632898086748
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/514	20/9376	3.64824902723735	SQLE/MSMO1/EBP/FDFT1	2.85515728415744
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/514	155/9376	1.76528178737291	HLA-G/TUBA1C/CALR/TUBA1B/TUBB/ACTB/ITGA5/TUBB4B/CTSL/ATP6V1C2/TUBB6/SEC61G/C1R/RAC1/SEC61B	2.31366001325421
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/514	128/9376	1.85262645914397	RRM2/PRPS2/NME1/AK5/APRT/ADK/PAICS/GUK1/PNP/HDDC2/ATIC/IMPDH2/ADCY1	2.33905915292364
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/514	157/9376	1.74279412129173	HLA-G/CCNE1/CCNB1/CALM1/PPP1CB/VDAC1/CALM3/CCNB2/SLC25A5/CDK1/PIK3CB/CHEK1/CCNA2/MYBL2/PPP3CA	2.26036045912126
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/514	31/9376	2.94213631228819	PRPS2/TKT/TALDO1/PFKP/ALDOA	2.60838820259164
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/514	144/9376	1.77345438824038	PSMA7/VDAC1/PSMB6/PSMB1/PSMA4/PSMB3/SLC25A5/PSMD2/PIK3CB/CYCS/PSMD14/PSMB2/PSMA1/PSMC4	2.25252376052731
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/514	54/9376	2.36460585098717	LDHB/ADI1/LDHA/SRM/AHCY/SMS/MDH2	2.42187031756918
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/514	107/9376	1.8752681915706	CALM1/LDHB/SLC2A1/PKM/CALM3/PYGL/LDHA/GNAS/PFKP/PGAM1/PPP3CA	2.19289540996686
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/514	56/9376	2.28015564202335	B4GALT1/MAN1A2/TUSC3/RPN2/OSTC/STT3A/STT3B	2.31392968067625
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/514	205/9376	1.60167030464079	HLA-G/CCNE1/RANBP1/YWHAE/PKM/GRB2/SKP2/CDC42/CDC20/CDK1/YWHAB/PIK3CB/CHEK1/CCNA2/ACTN1/YWHAG/HNRNPK/RAC1	2.09762807052786
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/514	82/9376	2.00208788080099	HLA-G/CALR/HSPA8/HSPA5/CTSL/HSPA2/PDIA3/PSME2/NFYB	2.19488983298566
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/514	34/9376	2.68253604943923	POLR2L/POLR2F/POLR2J/POLR2H/POLR2I	2.36692899564522
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/514	110/9376	1.82412451361868	CCNB1/IGF1/ANAPC11/CCNB2/MAD2L1/AURKA/CDK1/PIK3CB/CCNA2/ANAPC15/ADCY1	2.0938441451899
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/514	139/9376	1.70601573216135	KRT19/KRT18/CALM1/MMP2/HSPA8/KRT23/GRB2/CALM3/GNAS/PIK3CB/KRT10/HSP90B1/ADCY1	2.0195640520682
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/514	47/9376	2.32866959185363	LDHB/PKM/LDHA/ACAT2/ADH5/MDH2	2.19912392326583
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/514	212/9376	1.54878496439322	PGF/PFN1/CALM1/ACTB/EFNA1/IGF1/CALM3/ID1/CTNNB1/CDC42/RAC3/GNAS/FLT4/PIK3CB/TIAM1/PRKCZ/RAC1/ADCY1	1.94638576241023
NA	NA	hsa04518	Integrin signaling	14/514	154/9376	1.65829501238062	PGF/ACTB/IGF1/ITGA5/CTNNB1/CDC42/RAC3/FLNB/LAMA4/FLT4/PIK3CB/ACTN1/RAC1/COL4A1	1.98367121332458
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/514	36/9376	2.53350626891483	SSBP1/RNASEH2A/RPA3/MCM7/RNASEH2C	2.22005990205089
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/514	214/9376	1.53431033855777	HLA-G/CCNB1/CALR/CALM1/CFL1/CALM3/CCNB2/WEE1/RAC3/CDK1/PDIA3/PIK3CB/CHEK1/CYCS/RBX1/RAC1/AP1M2/PPP3CA	1.90417406345712
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/514	142/9376	1.66997314627062	RPS27A/UBA52/UBE2C/UBE2S/ANAPC11/SKP2/UBE2L3/CDC20/CBLB/UBC/UBE2F/RBX1/ANAPC15	1.93734942276157
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/514	232/9376	1.4938950758084	PFN1/CFL1/ACTB/EZR/PPP1CB/ITGA5/ARPC3/CDC42/RAC3/ARPC1B/ARPC2/ARPC5/DIAPH3/PIK3CB/ARPC4/TIAM1/MYL12B/ACTN1/RAC1	1.83447545280619
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/514	203/9376	1.52759195721761	PGF/ACTB/PPP1CB/IGF1/GRB2/ITGA5/CTNNB1/CDC42/RAC3/FLNB/LAMA4/FLT4/PIK3CB/MYL12B/ACTN1/RAC1/COL4A1	1.83017160684147
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/514	89/9376	1.84462029467057	TUBA1C/TUBA1B/TUBB/GRB2/TUBB4B/GNAS/CDK1/TUBB6/ADCY1	1.92805810505412
NA	NA	hsa04519	Cadherin signaling	30/514	404/9376	1.35454790615248	KRT19/KRT7/KRT18/DSC2/KRT8/YWHAE/ACTB/DSP/PPP1CB/LIMA1/KRT23/CTNNB1/ARPC3/CDC42/RAC3/DSG2/YWHAB/CDH5/ARPC1B/ARPC2/TCF7L2/WNT7A/ARPC5/PKP3/FLT4/ARPC4/ACTN1/YWHAG/RAC1/KRT10	1.75437447438242
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/514	76/9376	1.92013106696703	PPARG/PLIN2/SCD/HMGCS1/DBI/UBC/FABP7/ACSL4	1.93961860395484
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/514	76/9376	1.92013106696703	CALM1/ACTB/EZR/GAST/CALM3/CA2/GNAS/ADCY1	1.93961860395484
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/514	51/9376	2.14602883955138	ACTB/PDIA4/GNAS/ATP6V1C2/SEC61G/SEC61B	1.97632124551229
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/514	39/9376	2.338621171306	GCSH/AHCY/GLDC/MTHFD1L/ATIC	2.01737966272748
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/514	78/9376	1.8708969370448	ENO1/LSM4/LSM3/LSM7/LSM5/HSPD1/PFKP/LSM2	1.86003286736845
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/514	194/9376	1.50443258855149	TUBA1C/TPM1/TUBA1B/TUBB/ACTB/TNNI2/TUBB4B/TPM2/MYL6/DYNLL1/TPM3/TUBB6/KIF21A/KIF2C/MYL12B/MYL4	1.70976602037702
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/514	137/9376	1.5977732966003	TUBA1C/TUBA1B/ACTB/BIRC5/CTSL/CTSV/LMNB2/LMNB1/PARP1/PIK3CB/CYCS/GZMB	1.69740561875678
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/514	30/9376	2.43216601815824	ACLY/MDH2/IDH1/IDH2	1.89209278051531
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/514	30/9376	2.43216601815824	ABCG2/GGH/ATIC/FOLR1	1.89209278051531
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/514	82/9376	1.7796336718231	MGST3/MGST1/GSTP1/RRM2/NME1/TK1/DUT/IMPDH2	1.7076446612347
NA	NA	hsa04382	Cornified envelope formation	17/514	217/9376	1.42903763739712	KRT19/S100A11/KRT7/KRT18/CLDN7/KRT8/DSP/CLDN4/KRT23/PRSS8/CLDN10/DSG2/PADI1/PKP3/CLDN19/KRT10/COL4A1	1.53993558448452
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/514	98/9376	1.67521639005797	CFL1/ARPC3/CDC42/ARPC1B/ARPC2/ARPC5/PIK3CB/ARPC4/RAC1	1.61819238951804
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/514	233/9376	1.40919490322473	TPM1/DSC2/ENO1/ACTB/DSP/TNNI2/ITGA5/TPM2/TPM3/LMNB2/LMNB1/DSG2/SDC4/DIAPH3/PDLIM2/MYL4/CSRP1/COL4A1	1.52322879555795
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/514	204/9376	1.43068589303426	RPS6/MMP2/ACTB/EZR/PPP1CB/IGF1/GRB2/ITGA5/CTNNB1/CTSL/CDC42/SDC4/WNT7A/PIK3CB/TIAM1/RAC1	1.49776967185133
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/514	32/9376	2.28015564202335	AKR1B1/B4GALT1/UGP2/PFKP	1.74691861938769
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/514	59/9376	1.85504187825628	RRM2/NME1/TK1/DTYMK/HDDC2/DUT	1.58663368035462
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/514	87/9376	1.67735587459189	BIRC5/GRB2/CTNNB1/RAC3/TCF7L2/PIK3CB/CYCS/RAC1	1.52859829711852
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/514	103/9376	1.59389520607457	PRDX1/SERPINB9/GNAS/LAMA4/PIK3CB/ACTN1/ARG2/COL4A1/ADCY1	1.4595521835113
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/514	75/9376	1.70251621271077	MGST3/MGST1/GSTP1/BIRC5/TOP2A/PIK3CB/CYCS	1.47103662518754
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/514	75/9376	1.70251621271077	CGA/GPX3/HSPA5/PDIA4/GNAS/HSP90B1/ADCY1	1.47103662518754
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/514	61/9376	1.79422083306755	MT1G/MT1H/MT1E/MT1F/MT1X/SLC6A19	1.49870476295268
NA	NA	hsa03272	Virion - Hepatitis viruses	5/514	48/9376	1.90012970168612	CLDN7/CLDN4/CLDN10/LDLR/CLDN19	1.50568029657274
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/514	35/9376	2.08471372984992	AKR1B1/TPI1/PFKP/ALDOA	1.54829531014155
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/514	106/9376	1.54878496439322	CCNE1/GSTP1/IGF1/GRB2/CTNNB1/TCF7L2/PIK3CB/HSP90B1/FOLR1	1.36841111929888
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/514	138/9376	1.45401229346416	RPS6/CALM1/PPP1CB/GRB2/CALM3/PYGL/CBLB/PTPRF/PIK3CB/FASN/PRKCZ	1.2939559789714
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/514	138/9376	1.45401229346416	ACTB/ITGA5/ARPC3/CDC42/RAC3/ARPC1B/ARPC2/ARPC5/PIK3CB/ARPC4/RAC1	1.2939559789714
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/514	93/9376	1.5691393665537	CGA/CALM1/MMP2/GRB2/CALM3/CDC42/GNAS/ADCY1	1.32836446738038
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/514	93/9376	1.5691393665537	CCNE1/CKS2/CKS1B/SKP2/LAMA4/PIK3CB/CYCS/COL4A1	1.32836446738038
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/514	50/9376	1.82412451361868	HBA2/HBA1/HBB/GYPA/GYPB	1.40712103033201
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/514	37/9376	1.97202650120938	HBA2/HBA1/HBB/LAMA4	1.42669160192798
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/514	37/9376	1.97202650120938	PPARG/CTNNB1/TPM3/TCF7L2	1.42669160192798
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/514	156/9376	1.4031727027836	CLDN7/YWHAE/CLDN4/GRB2/CTNNB1/CLDN10/YWHAB/LDLR/PIK3CB/CLDN19/CYCS/YWHAG	1.22289532175246
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/514	157/9376	1.39423529703338	YWHAE/ACTB/BIRC5/PPP1CB/ID1/CTNNB1/BMP7/YWHAB/TCF7L2/WNT7A/YWHAG/PRKCZ	1.19967814965273
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/514	14/9376	2.6058921623124	B4GALT1/B3GNT7	1.44809616298621
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/514	70/9376	1.56353529738744	SLC2A1/GRB2/CDC42/PIK3CB/RBX1/RAC1	1.13969841501771
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/514	70/9376	1.56353529738744	HLA-G/ACTB/CD55/RAC3/CYCS/RAC1	1.13969841501771
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/514	41/9376	1.7796336718231	GCSH/ALAS2/GLDC/PGAM1	1.204832516111
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/514	86/9376	1.48475251108497	DSC2/ACTB/DSP/ITGA5/CTNNB1/DSG2/TCF7L2	1.08758387754361
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/514	28/9376	1.9544191217343	AKR1B1/GGH/GCH1	1.21803598900257
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/514	15/9376	2.43216601815824	AK5/ACP1	1.33683927592134
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/514	57/9376	1.60010922247252	SCD/ACAT2/TECR/FASN/ACSL4	1.09442094978193
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/514	216/9376	1.26675313445741	CALM1/HSPA8/HSPA5/PPARG/CALM3/CDC42/HSPD1/LDLR/HSPA2/PIK3CB/CCL3L1/CYCS/RAC1/HSP90B1/PPP3CA	0.955190500863024
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/514	105/9376	1.38980915323328	TPM1/ACTB/IGF1/ITGA5/TPM2/TPM3/GNAS/ADCY1	0.96735240685358
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/514	90/9376	1.4187635105923	SLC2A1/ABCG2/CA2/GNAS/LDLR/HMGCR/ADCY1	0.961340130104642
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/514	122/9376	1.34566562480066	LEP/PPARG/IGF1/SCD/PFKP/PIK3CB/CCNA2/FASN/HMGCR	0.925492034594969
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/514	60/9376	1.5201037613489	CDC42/RAC3/PIK3CB/RAC1/PPP3CA	0.973312284261342
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/514	32/9376	1.71011673151751	LDHB/LDHA/PCCA	0.969035404371593
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/514	18/9376	2.02680501513186	FASN/ACSL4	1.05010817192015
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/514	227/9376	1.20536862133393	HLA-G/CALR/CALM1/GRB2/CALM3/CTNNB1/RAC3/GNAS/PDIA3/PIK3CB/CCL3L1/CYCS/RAC1/PPP3CA/ADCY1	0.754330255620455
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/514	48/9376	1.5201037613489	HMGCS1/ACAT2/HSD17B10/PCCA	0.869996828423154
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/514	178/9376	1.22974686311371	NOTUM/CTNNB1/CACYBP/RAC3/TCF7L2/WNT7A/DKK1/LGR4/RUVBL1/RBX1/RAC1/PPP3CA	0.745270985395915
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/514	19/9376	1.92013106696703	GCSH/GLDC	0.966850897920268
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/514	65/9376	1.4031727027836	CYP11A1/HSD3B1/GNAS/LDLR/ADCY1	0.785508628459168
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/514	98/9376	1.3029460811562	CALM1/CYP11A1/HSD3B1/CALM3/GNAS/LDLR/ADCY1	0.726026574857266
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/514	99/9376	1.28978500962937	CALM1/PPP1CB/IGF1/CALM3/GNAS/PIK3CB/ADCY1	0.698057278615873
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/514	67/9376	1.3612869504617	CALM1/PPP1CB/CALM3/PPP3CA/ADCY1	0.714725844297605
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/514	36/9376	1.5201037613489	AKR1B1/DCXR/UGP2	0.752955190912666
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/514	101/9376	1.26424471240898	CALM1/CALM3/CTNNB1/GNAS/TCF7L2/WNT7A/ADCY1	0.643000570635325
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/514	69/9376	1.32182935769469	CALM1/PPP1CB/CALM3/GNAS/PPP3CA	0.646169822588841
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/514	205/9376	1.15676188668501	HLA-G/CCNE1/CALR/ISG15/SKP2/PSMD2/PDIA3/PIK3CB/CCNA2/CYCS/RAC1/PSMD14/PSMC4	0.546525449840362
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/514	88/9376	1.24372125928546	TFPI/CFD/CD55/PROCR/C1R/SERPINB2	0.553190828202043
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/514	23/9376	1.58619522923363	SSBP1/RPA3	0.677847588397581
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/514	56/9376	1.3029460811562	HSPA8/BNIP3/HSPD1/CYCS	0.547586485440103
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/514	108/9376	1.18230292549359	RAN/RBM8A/KPNA2/NUP37/THOC7/ALYREF/KPNB1	0.458895530747198
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/514	160/9376	1.14007782101167	HLA-G/CLDN7/CLDN4/CLDN10/SDC4/CDH5/PTPRF/F11R/PTPRS/CLDN19	0.430387312903871
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/514	196/9376	1.11681092670531	HLA-G/RPS27A/CALM1/UBA52/CALM3/CTNNB1/TCF7L2/UBC/PIK3CB/CYCS/RAC1/PPP3CA	0.398007713859396
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/514	250/9376	1.09447470817121	HLA-G/HSPA8/RAB11A/ARPC3/CDC42/ARPC1B/ARPC2/LDLR/CBLB/ARPC5/ARPC4/PRKCZ/FOLR1/CHMP2A/CLTA	0.364625179594246
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/514	76/9376	1.20008191685439	CALM1/IGF1/GRB2/CALM3/PIK3CB	0.421768835091003
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/514	59/9376	1.23669458550419	CGA/GNAS/PIK3CB/ADCY1	0.439215447650808
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/514	59/9376	1.23669458550419	GRB2/CTNNB1/TCF7L2/PIK3CB	0.439215447650808
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/514	42/9376	1.3029460811562	CP/GPX4/ACSL4	0.473868031251331
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/514	77/9376	1.18449643741473	RALBP1/CDC42/RAC3/PIK3CB/RAC1	0.391486281459022
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/514	43/9376	1.2726450095014	ACAT2/ADH5/ACSL4	0.43154140628046
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/514	78/9376	1.169310585653	CALM1/CFL1/CALM3/ITGA5/C1R	0.361607947751662
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/514	44/9376	1.24372125928546	HLA-G/HSPD1/GZMB	0.390241732860757
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/514	44/9376	1.24372125928546	RAB11A/DYNLL1/GNAS	0.390241732860757
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/514	27/9376	1.35120334342124	HMGCS1/ACAT2	0.440108005850245
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/514	27/9376	1.35120334342124	SCD/TECR	0.440108005850245
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/514	62/9376	1.17685452491528	HSPA8/IGF1/PIK3CB/ADCY1	0.336469132734436
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/514	170/9376	1.07301441977569	MGST3/MGST1/ACTB/GSTP1/GRB2/CTNNB1/TCF7L2/WNT7A/PIK3CB/SMARCA2	0.231365680524302
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/514	28/9376	1.3029460811562	CA2/ATP6V1C2	0.386621790335702
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/514	99/9376	1.10553000825374	MMP2/IGF1/GRB2/GNAS/PIK3CB/ADCY1	0.254209113398022
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/514	99/9376	1.10553000825374	KRT19/KRT18/CFD/KRT23/C1R/KRT10	0.254209113398022
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/514	99/9376	1.10553000825374	TPM1/ACTB/IGF1/ITGA5/TPM2/TPM3	0.254209113398022
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/514	46/9376	1.18964642192522	ALAS2/CP/CPOX	0.310516063650933
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/514	154/9376	1.06604679367325	NME1/UGP2/AK5/GGH/RFK/ALAS2/MTHFD1L/GCH1/CPOX	0.199021898811332
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/514	154/9376	1.06604679367325	TPM1/CALM1/PPP1CB/CALM3/TPM2/TPM3/GNAS/MYL4/ADCY1	0.199021898811332
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/514	29/9376	1.25801690594392	CALM1/CALM3	0.335129273810094
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/514	155/9376	1.05916907242375	CCNE1/CYP11A1/HSD3B1/CTNNB1/GNAS/TCF7L2/WNT7A/LDLR/ADCY1	0.178884587542732
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/514	47/9376	1.16433479592681	PKM/PIK3CB/PRKCZ	0.271995824517582
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/514	101/9376	1.08363832492199	MMP2/CDC42/PIK3CB/PRKCZ/RAC1/COL4A1	0.203521539415263
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/514	83/9376	1.09887018892691	PRDX1/PRDX5/IDH1/ACSL4/IDH2	0.217885217556486
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/514	120/9376	1.06407263294423	CALM1/YWHAE/GRB2/CALM3/CDC42/PIK3CB/RAC1	0.170119009640574
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/514	193/9376	1.03965645853914	GRB2/CDC42/CCR7/RAC3/PIK3CB/CCL3L1/TIAM1/PRKCZ/RAC1/CXCL13/ADCY1	0.134060740757834
NA	NA	hsa04981	Folate transport and metabolism	2/514	31/9376	1.17685452491528	ABCG2/FOLR1	0.237524654394856
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/514	68/9376	1.07301441977569	GRB2/TCF7L2/PIK3CB/CCNA2	0.145524539021461
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/514	105/9376	1.04235686492496	RPS27A/UBA52/BNIP3/TOMM20/UBC/PHB2	0.105113014643373
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/514	13/9376	1.4031727027836	XRCC5	0.350313286556755
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/514	50/9376	1.09447470817121	SRM/SMS/ARG2	0.161307358906804
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/514	69/9376	1.05746348615575	GRB2/RAC3/PIK3CB/RAC1	0.115375337168044
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/514	69/9376	1.05746348615575	CALM1/CALM3/GNAS/PPP3CA	0.115375337168044
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/514	180/9376	1.01340250756593	HLA-G/CALR/PPP1CB/ITGA5/SRSF3/SRSF2/PDIA3/PIK3CB/ALYREF/CYCS	0.0437244300527961
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/514	32/9376	1.14007782101167	BIRC5/CYCS	0.191152189355492
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/514	217/9376	1.00873244992738	MGST3/MGST1/BIRC5/GRB2/KPNA2/GNAS/PTGES3/PIK3CB/KLF5/HSP90B1/KPNB1/ADCY1	0.0313431951203225
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/514	144/9376	1.01340250756593	IGF1/GRB2/ID1/CTNNB1/ID3/DLX5/WNT7A/PIK3CB	0.0390319936145033
Organismal Systems	Immune system	hsa04611	Platelet activation	7/514	126/9376	1.01340250756593	ACTB/PPP1CB/GNAS/PIK3CB/MYL12B/PRKCZ/ADCY1	0.0364755452074502
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/514	89/9376	1.02478905259476	ITGA5/SDC4/LAMA4/HMMR/COL4A1	0.056587242898995
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/514	238/9376	0.996370532648857	PGF/RALBP1/CALM1/EFNA1/IGF1/GRB2/CALM3/CDC42/RAC3/FLT4/PIK3CB/TIAM1/RAC1	-0.0136586293722742
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/514	33/9376	1.10553000825374	IDH1/IDH2	0.146248389560504
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/514	71/9376	1.02767578232038	CDC42/ATP6V1C2/F11R/RAC1	0.0563731387958799
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/514	109/9376	1.00410523685432	SLC2A1/PPP1CB/PYGL/PTPRF/PIK3CB/PRKCZ	0.0103820522776999
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/514	184/9376	0.99137201827102	CFL1/EFNA1/CDC42/RAC3/BMP7/PIK3CB/MYL12B/PRKCZ/RAC1/PPP3CA	-0.0284652134822211
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/514	53/9376	1.03252330959548	RAB11A/GNAS/CLTA	0.0571815799384289
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/514	91/9376	1.002266216274	GRB2/RAC3/PIK3CB/RAC1/PPP3CA	0.00523157458035327
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/514	73/9376	0.999520281434891	MGST3/MGST1/GSTP1/ADH5	-0.000990918120901771
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/514	54/9376	1.01340250756593	CGA/HLA-G/GZMB	0.0237864546978491
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/514	130/9376	0.982220891948518	MMP2/GRB2/GNAS/PIK3CB/PRKCZ/COL4A1/ADCY1	-0.0491593379921543
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/514	93/9376	0.980712104096063	CALM1/CALM3/CST3/GNAS/ADCY1	-0.045017718110884
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/514	16/9376	1.14007782101167	MIF	0.135049434270745
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/514	36/9376	1.01340250756593	PYGL/UGP2	0.0194028353435516
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/514	133/9376	0.960065533483514	CCNB1/IGF1/GRB2/BNIP3/CCNB2/SKP2/PIK3CB	-0.111703956501352
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/514	133/9376	0.960065533483514	HLA-G/GRB2/RAC3/PIK3CB/GZMB/RAC1/PPP3CA	-0.111703956501352
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/514	134/9376	0.95290086532319	CALM1/RAMP1/PPP1CB/CALM3/MYL6/GNAS/ADCY1	-0.132246342623986
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/514	115/9376	0.951717137540179	GCM1/NACA/GATA3/GNAS/MMP15/ADCY1	-0.125462608390143
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/514	37/9376	0.98601325060469	MIF/ADH5	-0.0205290471769361
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/514	37/9376	0.98601325060469	UGP2/GNPNAT1	-0.0205290471769361
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/514	154/9376	0.94759714993178	CALM1/ACTB/PPP1CB/CALM3/MYL6/GNAS/PPP3CA/ADCY1	-0.157907964091317
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/514	17/9376	1.07301441977569	CA2	0.0725637469663714
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/514	38/9376	0.960065533483514	UGP2/GNPNAT1	-0.0594037792361637
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/514	38/9376	0.960065533483514	IGF1/PIK3CB	-0.0594037792361637
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/514	117/9376	0.935448468522398	ACTB/MORF4L2/CDK2AP2/RUVBL1/SMARCA2/ACTR6	-0.169207170801937
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/514	79/9376	0.923607348667685	MGST3/MGST1/GSTP1/ADH5	-0.164208274747444
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/514	18/9376	1.01340250756593	PRDX1	0.0137066750861155
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/514	39/9376	0.935448468522398	HLA-G/GZMB	-0.0972828979492198
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/514	80/9376	0.912062256809339	RPS6/IGF1/GRB2/PIK3CB	-0.190227621006747
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	17/514	333/9376	0.931234736682208	HLA-G/CCNE1/ISG15/PKM/GRB2/ITGA5/CTNNB1/CDC42/GNAS/ATP6V1C2/TCF7L2/WNT7A/LAMA4/PIK3CB/CCNA2/PRKCZ/COL4A1	-0.307706228021803
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/514	102/9376	0.89417868314641	RAB11A/CA2/GNAS/RAC1/ADCY1	-0.25878614822604
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/514	122/9376	0.897110416533776	DIO2/ACTB/SLC2A1/CTNNB1/PFKP/PIK3CB	-0.27547862184936
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/514	41/9376	0.88981683591155	SSBP1/RPA3	-0.170275173609845
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/514	103/9376	0.885497336708096	CALR/GNAS/PIK3CB/CCL3L1/ADCY1	-0.281400843980837
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/514	20/9376	0.912062256809339	UGP2	-0.0948083376755189
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/514	63/9376	0.868630720770799	PTGDS/GPX4/PTGES3	-0.251953627342986
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/514	63/9376	0.868630720770799	CTNNB1/TCF7L2/WNT7A	-0.251953627342986
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/514	105/9376	0.868630720770799	CALM1/CALM3/CBLB/PIK3CB/PPP3CA	-0.32600668146173
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/514	21/9376	0.868630720770799	B4GALT7	-0.145138587913745
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/514	65/9376	0.841903621670159	CGA/KISS1/PIK3CB	-0.30802201748488
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/514	44/9376	0.829147506190308	CDK7/TAF10	-0.273565685009791
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/514	44/9376	0.829147506190308	HMGB1/PARP1	-0.273565685009791
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/514	148/9376	0.862761594279104	IGF1/GRB2/CTNNB1/TCF7L2/WNT7A/FLT4/PIK3CB	-0.405278956181844
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/514	66/9376	0.829147506190308	CYP11A1/HSD3B1/CYP19A1	-0.33544380398612
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/514	45/9376	0.810722006052745	ABCG2/ABCA7	-0.306509268393177
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/514	45/9376	0.810722006052745	HLA-G/GZMB	-0.306509268393177
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/514	23/9376	0.793097614616816	ARG2	-0.239251832787949
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/514	23/9376	0.793097614616816	B4GALT1	-0.239251832787949
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/514	23/9376	0.793097614616816	CA2	-0.239251832787949
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/514	68/9376	0.804760814831769	ALDH1A3/ALDH1A2/ADH5	-0.389129880204722
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/514	90/9376	0.810722006052745	PPARG/IGF1/PIK3CB/ADCY1	-0.434518592772881
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/514	173/9376	0.843525786644475	ACTB/VDAC1/FDPS/KPNA2/RAB11A/SLC25A5/PIK3CB/CYCS	-0.500267675718339
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/514	24/9376	0.760051880674449	B4GALT7	-0.283447118913198
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/514	70/9376	0.781767648693719	LEP/SLC2A1/ACSL4	-0.441354900114375
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/514	70/9376	0.781767648693719	MGST3/MGST1/GSTP1	-0.441354900114375
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/514	71/9376	0.770756836740286	CGA/GRB2/PIK3CB	-0.466948197194387
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/514	49/9376	0.744540617803542	B4GALT1/GALNT2	-0.431767783348947
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/514	136/9376	0.804760814831769	CCNE1/HSPA8/CBLB/PIK3CB/CYCS/EIF3H	-0.552334002530454
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/514	158/9376	0.808156430084224	RPS6/IGF1/GRB2/SKP2/ATP6V1C2/WNT7A/PIK3CB	-0.585677801787069
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/514	95/9376	0.768052426786811	CTSL/ATP6V1C2/CCL3L1/IL15	-0.547211951559416
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/514	97/9376	0.752216294275743	CALM1/CALM3/GNAS/ADCY1	-0.590757642023736
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/514	52/9376	0.701586351391799	VDAC1/LDLR	-0.519661505195432
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/514	140/9376	0.781767648693719	RPS6/CALM1/CALM3/MYL4/APLNR/ADCY1	-0.626530925349848
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/514	98/9376	0.744540617803542	CALM1/CALM3/IMPA2/PIK3CB	-0.612222147133899
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/514	28/9376	0.651473040578099	TECR	-0.444792408331166
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/514	28/9376	0.651473040578099	B4GALT1	-0.444792408331166
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/514	163/9376	0.783366355541763	CCNE1/BIRC5/GRB2/YWHAB/PIK3CB/CCNA2/CYCS	-0.671924531922117
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/514	99/9376	0.737020005502496	GRB2/RAC3/PIK3CB/RAC1	-0.633487217037679
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/514	226/9376	0.807134740539238	CGA/CALM1/PPP1CB/CALM3/RAC3/GNAS/PIK3CB/TIAM1/RAC1/ADCY1	-0.70680400750191
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/514	143/9376	0.765366928791053	SNRPD1/SNRPB/C1R/SNRPD3/ACTN1/SSB	-0.680905984321051
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/514	54/9376	0.675601671710621	UBE2T/RPA3	-0.575734511019984
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/514	122/9376	0.747592013778146	GRB2/CDC42/CBLB/PIK3CB/PPP3CA	-0.67580217399747
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/514	122/9376	0.747592013778146	IGF1/GRB2/GNAS/PIK3CB/ADCY1	-0.67580217399747
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/514	78/9376	0.701586351391799	TPI1/IMPA2/PIK3CB	-0.63734199865953
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/514	166/9376	0.76920913224884	CALM1/PPP1CB/VDAC1/CALM3/SLC25A5/PPP3CA/ADCY1	-0.722510518146811
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/514	168/9376	0.760051880674449	HMGB1/PPIA/VDAC1/PYGL/SLC25A5/PARP1/CHMP2A	-0.75577176108065
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/514	103/9376	0.708397869366476	RBM8A/PPP1CB/PAPOLA/ALYREF	-0.716639100853871
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/514	169/9376	0.755554532268091	HMGB1/RPS27A/UBA52/BNIP3/CTSL/UBC/PIK3CB	-0.772267209368696
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/514	150/9376	0.729649805447471	CCNE1/GRB2/CTNNB1/TCF7L2/WNT7A/PIK3CB	-0.803835006815854
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/514	83/9376	0.659322113356148	CBX3/AURKB/EZH2	-0.750769026070642
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/514	83/9376	0.659322113356148	POLR2L/POLR2F/POLR2H	-0.750769026070642
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	16/514	362/9376	0.806242878947482	RPS6/CCNE1/PGF/YWHAE/EFNA1/IGF1/GRB2/ITGA5/YWHAB/LAMA4/FLT4/PIK3CB/YWHAG/RAC1/COL4A1/HSP90B1	-0.905429220382698
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/514	60/9376	0.608041504539559	IGF1/GNAS	-0.733503671580493
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/514	34/9376	0.536507209887846	RBX1	-0.65202437983697
NA	NA	hsa04081	Hormone signaling	9/514	219/9376	0.749640211076169	CGA/LEP/DIO2/RAMP1/GAST/IGF1/GNAS/PIK3CB/ADCY1	-0.902841163782745
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/514	86/9376	0.636322504750701	GRB2/CBLB/PIK3CB	-0.8159416844965
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/514	86/9376	0.636322504750701	SLC2A1/GNAS/ADCY1	-0.8159416844965
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/514	110/9376	0.663318004952246	ID1/ID3/BMP7/RBX1	-0.855404265341123
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/514	133/9376	0.685761095345367	CALM1/PPP1CB/CALM3/GNAS/PPP3CA	-0.878983294345076
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/514	63/9376	0.579087147180532	ACAT2/EZH2	-0.807270319860107
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/514	157/9376	0.697117648516692	CALR/SLC2A1/PPARG/SLC16A1/ARG2/RAC1	-0.921686469284337
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/514	36/9376	0.506701253782966	GALNT2	-0.714149520225563
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/514	112/9376	0.651473040578099	HSPA8/LDLR/LAMA4/CYCS	-0.893608807291605
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/514	37/9376	0.493006625302345	NIT2	-0.744139371729393
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/514	38/9376	0.480032766741757	PNP	-0.77346766913138
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/514	116/9376	0.629008452971958	GNAS/SLC38A1/PPP3CA/ADCY1	-0.968252976078055
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/514	142/9376	0.642297363950238	PPARG/GRB2/PIK3CB/RAC1/PPP3CA	-1.03436234620571
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/514	41/9376	0.444908417955775	MMP2	-0.857829018470269
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/514	144/9376	0.633376567228707	CTNNB1/SCD/TCF7L2/ADH5/FASN	-1.0677138898419
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/514	42/9376	0.434315360385399	ACAT2	-0.884843485877868
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/514	43/9376	0.424215003167134	ACAT2	-0.911350138786115
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/514	73/9376	0.499760140717446	RAN/PPIA	-1.03330739607366
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/514	73/9376	0.499760140717446	IGF1/PIK3CB	-1.03330739607366
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/514	73/9376	0.499760140717446	GRB2/PIK3CB	-1.03330739607366
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/514	100/9376	0.547237354085603	CCR7/CCL3L1/CXCL13	-1.09620440802134
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/514	100/9376	0.547237354085603	CD55/ITGA5/GYPA	-1.09620440802134
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/514	125/9376	0.583719844357977	RAC3/PIK3CB/PRKCZ/RAC1	-1.12836004413365
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/514	77/9376	0.47379857496589	GRB2/PIK3CB	-1.11655618976521
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/514	48/9376	0.380025940337224	PIK3CB	-1.0370535760256
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/514	79/9376	0.461803674333842	ATP6V1C2/CLTA	-1.15686899946185
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/514	181/9376	0.604682159210611	CALM1/CALM3/HSPD1/CYCS/NFYB/PPP3CA	-1.2933353858467
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/514	49/9376	0.372270308901771	GNAS	-1.06096497586989
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/514	50/9376	0.364824902723735	IL15	-1.0845063125184
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/514	109/9376	0.502052618427159	PIK3CB/CCL3L1/RAC1	-1.25929780192727
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/514	300/9376	0.668845654993515	PGF/STMN1/HSPA8/EFNA1/IGF1/GRB2/CDC42/RAC3/FLT4/RAC1/PPP3CA	-1.40392906871612
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/514	191/9376	0.57302340741948	CALM1/PPP1CB/GRB2/CALM3/GNAS/SLC29A1	-1.43576213376822
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/514	55/9376	0.331659002476123	GM2A	-1.19715261396345
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/514	89/9376	0.409915621037905	SLC38A1/ADCY1	-1.34701590371735
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/514	195/9376	0.561269081113439	HMGB1/ACTB/VDAC1/SLC25A5/PIK3CB/RAC1	-1.49098020834327
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/514	90/9376	0.405361003026373	PIK3CB/PPP3CA	-1.36509107469123
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/514	91/9376	0.400906486509599	GNAS/ADCY1	-1.3830111593458
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/514	149/9376	0.489697856005014	GRB2/GNAS/PIK3CB/ADCY1	-1.51213857239895
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/514	93/9376	0.392284841638425	GATA3/PPP3CA	-1.41839990360215
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/514	323/9376	0.62121887460698	CCNE1/TPM1/STMN1/EZR/EFNA1/GRB2/ITGA5/PIK3CB/EZH2/SLC7A1/HNRNPK	-1.66837877395029
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/514	254/9376	0.57452740586415	CALM1/VDAC1/CALM3/SLC25A5/GNAS/FLT4/PPP3CA/ADCY1	-1.65555929690176
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/514	65/9376	0.28063454055672	AKR1B1	-1.40155266342893
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/514	66/9376	0.276382502063436	GATA3	-1.42071678748296
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/514	103/9376	0.354198934683238	SLC6A19/COL4A1	-1.58711561459994
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/514	72/9376	0.253350626891483	ISG15	-1.53161435111357
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/514	168/9376	0.434315360385399	LEP/GRB2/PIK3CB/IL15	-1.78175381203029
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/514	109/9376	0.334701745618106	GATA3/PPP3CA	-1.6825244199956
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/514	250/9376	0.51075486381323	CTSL/GM2A/CTSV/ATP6V1C2/SLC29A1/AP1M2/CLTA	-1.88824182790207
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/514	201/9376	0.453762316820566	PPARG/IGF1/MYCN/CCNA2/GZMB	-1.8852891776985
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/514	115/9376	0.317239045846726	PIK3CB/ADCY1	-1.77414854569354
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/514	115/9376	0.317239045846726	GNAS/APP	-1.77414854569354
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/514	119/9376	0.306575548507341	PIK3CB/IL15	-1.8333223178772
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/514	183/9376	0.398715740681678	RAN/NHP2/FBL/POP7	-1.9782358797343
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/514	187/9376	0.390187061736615	TXN/YWHAE/VDAC1/TXN2	-2.02854495581271
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/514	94/9376	0.194055799321136	HSP90B1	-1.89125219116987
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/514	104/9376	0.17539658784795	PEMT	-2.03646246857133
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/514	105/9376	0.17372614415416	PARP1	-2.05048546588214
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/514	298/9376	0.36727339200376	LEP/CCR7/BMP7/CCL3L1/IL15/CXCL13	-2.67319392736165
NA	NA	hsa04082	Neuroactive ligand signaling	2/514	199/9376	0.183329096846098	GNAS/ADCY1	-2.8043006959342
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/514	370/9376	0.345104637711642	CGA/LEP/KISS1/GZMA/GAL/TMEM97/APLNR	-3.09533836444821
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/514	449/9376	0.0812527622992729	CALM1/CALM3	-4.80471657622068