category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	81/443	238/9376	7.20314130166739	SELP/RPL13/RPL37/RPLP0/RPS23/RPS11/RPL11/RPL34/RPS27/RPL18/RPS13/RPL29/RPL23A/RPS24/RPL13A/RPS4X/RPS18/RPL32/RPL18A/RPS15/RPS8/RPL24/RPL6/RPS3A/RPS29/RPS7/RPL21/RPS3/RPS6/RPS27A/RPS14/RPL7A/RPL14/RPL10/RPS20/RPL31/RPL35A/RPL27A/RPL23/RPL38/RPS12/RPL10A/RPS16/RPS15A/RPL7/RPL3/RPS25/RPL4/RPS2/RPL30/RPL5/RPL26/RPLP2/RPL8/RPSA/RPL28/RPL9/RPLP1/RPL37A/RPS28/RPL22/RPL39/RPL35/RPL36/RPS5/RPL19/RPS19/RPS9/RPL15/RPL27/RPL12/MAPK12/RPL41/RPS10/RPS21/F13A1/FAU/RPL36A/MASP1/C1QB/UBA52	21.5855644693403
Genetic Information Processing	Translation	hsa03010	Ribosome	76/443	222/9376	7.24560226140362	RPL13/RPL37/RPLP0/RPS23/RPS11/RPL11/RPL34/RPS27/RPL18/RPS13/RPL29/RPL23A/RPS24/RPL13A/RPS4X/RPS18/RPL32/RPL18A/RPS15/RPS8/RPL24/RPL6/RPS3A/RPS29/RPS7/RPL21/RPS3/RPS6/RPS27A/RPS14/RPL7A/RPL14/RPL10/RPS20/RPL31/RPL35A/RPL27A/RPL23/RPL38/RPS12/RPL10A/RPS16/RPS15A/RPL7/RPL3/RPS25/RPL4/RPS2/RPL30/RPL5/RPL26/RPLP2/RPL8/RPSA/RPL28/RPL9/RPLP1/RPL37A/RPS28/RPL22/RPL39/RPL35/RPL36/RPS5/RPL19/RPS19/RPS9/RPL15/RPL27/RPL12/RPL41/RPS10/RPS21/FAU/RPL36A/UBA52	20.9717267809414
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	23/443	184/9376	2.64559819413093	ROBO2/DPYSL5/TRPC6/ENAH/GNAI1/EFNB3/SEMA3D/PLXNA4/UNC5C/PTCH1/NFATC2/FYN/PARD3/RAC3/WNT5B/EFNB2/FZD3/EPHB4/TRPC1/PAK3/EPHA4/SEMA6A/RGMA	5.02014822216118
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/443	89/9376	3.09148553022041	COL2A1/GP9/ITGA2B/SV2A/FREM1/COL9A1/RELN/FREM2/GP1BA/COL4A5/LAMA4/COL6A3/LAMC1	4.41469779041537
NA	NA	hsa04519	Cadherin signaling	35/443	404/9376	1.83358290682341	CDH2/LEF1/KRT19/KRT18/ENAH/MPDZ/WASF1/KRT8/CTNNA3/FAT3/PCDH18/KRT7/MAPK12/JUP/CDH26/RAC3/NCKAP1/FZD7/ARPC1A/YWHAE/WNT5B/PRICKLE1/FZD3/AXIN2/TEAD2/DSP/LRP6/PCDH9/TEAD1/TEAD3/PKP2/MYO1B/KRT23/FZD10/FAT1	3.81402631337167
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/443	212/9376	2.19634567059926	KIT/ANGPT1/ITGA2B/F2R/MAGI1/ENAH/GNAI1/NGFR/MAPK12/PLCB4/LPAR4/TEK/PARD3/RAC3/IGF1/RASGRP2/PFN2/PGF/ADCY6/ID1/EGF/RAPGEF5	3.92347515476844
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/443	157/9376	2.42653592327932	SOX2/LEF1/CRB2/AMOT/CTNNA3/PARD3/FZD7/YWHAE/WNT5B/FZD3/AXIN2/TEAD2/DLG3/TEAD1/TEAD3/ID1/GLI2/FZD10	4.01401938628841
NA	NA	hsa04517	IgSF CAM signaling	27/443	299/9376	1.91120137101097	CDH2/ROBO2/PRKCQ/MAGI1/KCNQ2/TRPC6/LRRC4B/JAM3/TUBB2B/MPDZ/MYH10/TUBB1/PTPRZ1/PPFIA2/MAPK12/PLXNA4/UNC5C/ICAM3/FYN/PARD3/ARPC1A/SCN8A/CADM4/NLGN1/PAK3/ESAM/MYLK	3.56588739945488
Organismal Systems	Immune system	hsa04611	Platelet activation	14/443	126/9376	2.35164283922749	GP9/ITGA2B/F2R/TBXA2R/GNAI1/GUCY1A2/MAPK12/PLCB4/FYN/RASGRP2/GP1BA/ADCY6/P2RX1/MYLK	3.40145859230479
NA	NA	hsa04518	Integrin signaling	15/443	154/9376	2.06150508633579	COL2A1/ITGA2B/FREM1/COL9A1/RELN/ICAM3/RAC3/IGF1/FREM2/COL4A5/LAMA4/COL6A3/PGF/EGF/LAMC1	2.9577312865579
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/443	86/9376	2.46102157593574	ITGA2B/CDH2/LEF1/CTNNA3/SLC8A3/CACNG4/JUP/DSP/PKP2/CACNA2D2	3.03100625393175
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/443	144/9376	2.05768748432405	MEIS1/SOX2/ACVR2B/MAPK12/SMAD9/IGF1/FZD7/WNT5B/HAND1/FZD3/AXIN2/ISL1/ID1/FZD10	2.84825945556236
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/443	63/9376	2.68759181625999	LEF1/PTCH1/FZD7/WNT5B/FZD3/AXIN2/GLI2/FZD10	2.99282772361408
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/443	178/9376	1.90245263398179	LEF1/APCDD1/SFRP5/PLCB4/NFATC2/RAC3/FZD7/WNT5B/PRICKLE1/RSPO4/BAMBI/FZD3/AXIN2/LRP6/FZD10/ROR2	2.70692703590937
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/443	134/9376	2.05330009096729	PRKCQ/PPP1R14A/CALD1/MYH10/KCNMB4/GUCY1A2/PLCB4/RAMP2/RAMP1/ADCY6/CALCRL/PLA2G10/MYLK	2.73470429739844
Genetic Information Processing	Transcription	hsa03040	Spliceosome	20/443	243/9376	1.74195765868703	HNRNPA1/SRSF3/SNRPF/SRSF5/SNRPD2/U2AF1/HNRNPA3/HNRNPC/LSM7/SRSF7/SNRPD1/HNRNPK/SNRPD3/SNRPE/FUS/DDX5/HNRNPM/RBMX/SRSF2/RBM25	2.60954244022756
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/443	200/9376	1.79900677200903	F2R/RPS3/CLDN10/TUBB2B/WASF1/MYH10/TUBB1/WASF3/MAPK12/LPAR4/FYN/NCKAP1/ARPC1A/PAK3/NCL/MYO1B/CLDN6	2.54347568307021
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/443	203/9376	1.77242046503353	COL2A1/ITGA2B/COL9A1/RELN/FYN/RAC3/IGF1/COL4A5/LAMA4/PAK3/COL6A3/SHC2/PGF/CAV1/EGF/LAMC1/MYLK	2.4776213131105
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/443	148/9376	1.85906900128119	KIT/LEF1/IGF1/FZD7/WNT5B/HES5/FZD3/AXIN2/LRP6/NOTCH3/SHC2/EGF/FZD10	2.34581601705715
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/443	166/9376	1.78498191411243	PDE5A/TRPC6/GNAI1/PDE3A/KCNMB4/SLC8A3/GUCY1A2/PLCB4/ADRA2A/NFATC2/SLC25A6/ADCY6/GATA4/MYLK	2.2723368636778
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/443	233/9376	1.63504781096504	ITGA2B/MYL4/FBN3/FBLN2/TPM1/MYH10/COL9A1/JUP/PDLIM1/MYOZ3/TNNI3/SYNE2/DSP/COL4A5/COL6A3/TNNT2/PKP2/LMNB1	2.18589279347618
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/443	160/9376	1.7196388261851	CD34/CDH2/SELP/NRXN1/CLDN10/LRRC4B/JAM3/HLA-G/ICAM3/NRXN2/NLGN1/ESAM/CLDN6	2.04452384062087
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/443	41/9376	2.58107140890822	GAMT/ALAS2/PSAT1/PHGDH/GCSH	2.25930616178403
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/443	115/9376	1.8404161350476	NACA/WNK3/GNAI1/PLCB4/LRP6/MMP16/ADCY6/PDE4C/EGR1/MMP15	2.01931092148772
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/443	101/9376	1.88597098987551	KIT/LEF1/GNAI1/PLCB4/FZD7/WNT5B/FZD3/ADCY6/FZD10	1.99348083003244
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/443	149/9376	1.70454648749375	KIT/F2R/FCER1A/PLCB4/LPAR4/FYN/GRM3/MS4A2/DNM1/SHC2/ADCY6/EGF	1.93046246707851
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/443	86/9376	1.9688172607486	KCNMB4/PLCB4/KCNN2/SNAP25/CHRM3/PCLO/ADCY6/SLC2A1	2.00988898768676
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/443	150/9376	1.69318284424379	LEF1/CTNNA3/TERT/JUP/FZD7/WNT5B/FZD3/AXIN2/LRP6/SHC2/EGF/FZD10	1.90579219683758
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/443	87/9376	1.94618717729172	MYL4/TPM1/SLC8A3/CACNG4/TNNI3/TNNT2/MT-CO3/CACNA2D2	1.97442680033958
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/443	201/9376	1.57946160843637	HMGA2/ZBTB16/MEIS1/PBX1/RUNX1T1/ETV1/ERG/NGFR/HOXA11/JUP/IGF1/MYCN/MLLT3/FUS/DDX5	1.84930478819675
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/443	362/9376	1.40319020241198	COL2A1/KIT/ANGPT1/ITGA2B/F2R/MAGI1/RPS6/GNG11/NGFR/COL9A1/RELN/MYB/LPAR4/TEK/IGF1/YWHAE/HSP90AB1/COL4A5/LAMA4/COL6A3/PGF/EGF/LAMC1/NTF4	1.7421851711226
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/443	170/9376	1.61848360111539	MAGI1/CLDN10/JAM3/MPDZ/CGNL1/MYH10/AMOT/PARD3/ARPC1A/DLG3/GATA4/CLDN6/CRB3	1.81219946840934
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/443	105/9376	1.81412447597549	ITGA2B/TPM1/SLC8A3/CACNG4/IGF1/TNNI3/TNNT2/ADCY6/CACNA2D2	1.86814681988062
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/443	154/9376	1.64920406906863	MYL4/GNAI1/TPM1/SLC8A3/MAPK12/PLCB4/CACNG4/POPDC3/TNNI3/TNNT2/ADCY6/CACNA2D2	1.8089137877551
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/443	155/9376	1.63856404281657	PBX1/LEF1/GNAI1/PLCB4/STAR/FZD7/WNT5B/FZD3/AXIN2/CYP11A1/ADCY6/FZD10	1.78513116660762
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/443	20/9376	3.17471783295711	SQLE/DHCR7/TM7SF2	2.16801179848214
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/443	76/9376	1.94938814304384	GAST/GNAI1/PLCB4/SST/CHRM3/ADCY6/MYLK	1.8505377958904
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/443	140/9376	1.66294743631087	MYL4/RPS6/GNG11/GNAI1/SLC8A3/PLCB4/APLNR/NOTCH3/ADCY6/EGR1/MYLK	1.75990808127302
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	22/443	333/9376	1.39827412062175	COL2A1/ITGA2B/MAGI1/HLA-G/COL9A1/RELN/TERT/PARD3/FZD7/WNT5B/HES5/FZD3/AXIN2/COL4A5/LAMA4/DLG3/COL6A3/NOTCH3/EGF/FZD10/LAMC1/CRB3	1.64792246050816
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/443	93/9376	1.82062671424064	LEF1/WASF1/YES1/CTNNA3/WASF3/FYN/PARD3/RAC3	1.77105392189972
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/443	50/9376	2.11647855530474	HBA2/HBA1/SELP/GYPA/GYPB	1.76269233794632
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/443	115/9376	1.65637452154284	KCNQ2/GNG11/GNAI1/KCNQ5/PLCB4/FYN/CHRM3/ACHE/ADCY6	1.57710470404362
NA	NA	hsa04081	Hormone signaling	15/443	219/9376	1.44964284609914	NPR3/CGA/GAST/GNG11/LEP/GNAI1/TRH/PLCB4/SMAD9/ADRA2A/RAMP2/IGF1/SST/RAMP1/ADCY6	1.49934637068751
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/443	37/9376	2.28808492465377	HBA2/HBA1/PLCB4/LAMA4	1.74817138043927
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/443	99/9376	1.71028570125636	ITGA2B/TPM1/SLC8A3/CACNG4/IGF1/TNNI3/TNNT2/CACNA2D2	1.58210653821272
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/443	116/9376	1.64209543083988	GNG11/SLC38A1/GNAI1/SHANK3/PLCB4/GRM3/GRIK5/TRPC1/ADCY6	1.54957255224414
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/443	52/9376	2.03507553394687	CGA/STAR/IGF1/CYP11A1/ADCY6	1.66671528029415
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/443	170/9376	1.49398486256805	LEF1/GSTM5/TERT/GSTA4/FZD7/WNT5B/FZD3/AXIN2/LRP6/SHC2/GSTP1/FZD10	1.44740960590331
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/443	103/9376	1.64386683907164	COL2A1/COL25A1/COL9A1/SLC8A3/COL18A1/COL4A5/CPA3/COL6A3	1.46316523964644
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/443	88/9376	1.68356248717423	F2R/TFPI/F13A1/MASP1/A2M/CLU/C1QB	1.43465437922968
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/443	193/9376	1.42560731704464	GNG11/PF4/GNAI1/CX3CR1/PLCB4/PARD3/PPBP/RAC3/RASGRP2/CXCL14/SHC2/ADCY6/CCL4L2	1.33040626824986
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/443	89/9376	1.66464605473407	TUBB2B/GNAI1/TUBB1/GUCY1A2/PLCB4/ADCY6/EGF	1.40293175680424
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/443	27/9376	2.35164283922749	ELOVL6/ELOVL2/FADS2	1.56621033141741
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/443	142/9376	1.49047785584841	ITGA2B/GSTM5/ACVR2B/MAPK12/GSTA4/RAC3/HSP90AB1/CAV1/GSTP1/SUMO2	1.31146732892068
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/443	232/9376	1.36841285903324	ITGA2B/F2R/ENAH/WASF1/MYH10/LPAR4/RAC3/NCKAP1/ARPC1A/PFN2/PAK3/CHRM3/TMSB4Y/EGF/MYLK	1.26531745284403
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/443	44/9376	1.9240714139134	HLA-G/CPE/GAD1/LTA	1.3681488290356
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/443	29/9376	2.18946057445318	TEAD2/TEAD1/TEAD3	1.4285707823256
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/443	238/9376	1.33391505586433	KIT/ANGPT1/GNG11/NGFR/TEK/RAC3/IGF1/RASGRP2/PAK3/SHC2/PGF/PLA2G10/EGF/RAPGEF5/NTF4	1.1619507947861
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/443	78/9376	1.62806042715749	WASF1/CTNNA3/ARPC1A/DNM1/SHC2/CAV1	1.24034584161175
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/443	116/9376	1.45964038296879	CLDN10/JAM3/GNAI1/CTNNA3/MAPK12/THY1/ESAM/CLDN6	1.10925274833333
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/443	17/9376	2.48997477094675	CA8/CA9	1.36923340536873
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/443	17/9376	2.48997477094675	MYH10/PCDH9	1.36923340536873
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/443	65/9376	1.62806042715749	PBX1/PLCB4/STAR/CYP11A1/ADCY6	1.13148494430287
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/443	100/9376	1.48153498871332	PF4/CX3CR1/PPBP/IL18R1/CXCL14/CCL4L2/LTA	1.0780435688948
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/443	100/9376	1.48153498871332	CD34/KIT/GP9/ITGA2B/GYPA/CD7/GP1BA	1.0780435688948
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/443	102/9376	1.45248528305227	RAB27B/PLCB4/TRPC1/CPA3/CHRM3/ADCY6/PLA2G10	1.0231983541457
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/443	68/9376	1.55623423184172	ZBTB16/KIT/LEF1/RUNX1T1/JUP	1.02511553756499
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/443	69/9376	1.53368011253967	FCER1A/MAPK12/FYN/RAC3/MS4A2	0.990808085414349
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/443	69/9376	1.53368011253967	GNAI1/PDE3A/GUCY1A2/PLCB4/ADCY6	0.990808085414349
NA	NA	hsa04082	Neuroactive ligand signaling	12/443	199/9376	1.27626847556065	SLC18A2/GNG11/GNAI1/PLCB4/SLC6A9/ADRA2A/GRM3/GRIK5/CHRM3/ACHE/ADCY6/P2RX1	0.877195384583212
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/443	125/9376	1.35454627539503	FCER1A/GNAI1/MAPK12/PLCB4/FYN/CERS4/RAC3/MS4A2	0.888632980901591
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/443	53/9376	1.59734230589037	SLC8A3/PLCB4/DNM1/ADCY6	0.971118440775735
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/443	54/9376	1.56776189281833	DNMT3B/PSAT1/PHGDH/LDHB	0.931745716842534
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/443	110/9376	1.34684998973938	ANGPT1/RPS6/TEK/IGF1/EGF/SLC2A1/LDHB	0.814855713361893
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/443	110/9376	1.34684998973938	E2F5/ACVR2B/SMAD9/LTBP1/BAMBI/ID1/RGMA	0.814855713361893
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/443	130/9376	1.30244834172599	RXFP1/GNG11/GNAI1/MAPK12/PLCB4/COL4A5/SHC2/ADCY6	0.773276431461763
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/443	75/9376	1.41098570353649	CGA/PLCB4/LRP2/TTR/ADCY6	0.795758632648528
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/443	23/9376	1.8404161350476	CTSG/CPA3	0.898610868395708
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/443	115/9376	1.28829129453332	ALOX12/SLC18A2/GNG11/GNAI1/PLCB4/KCNN2/TRPC1	0.692692269155438
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/443	59/9376	1.43490071546084	GSTM5/GSTA4/PRDX6/GSTP1	0.746220051222699
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/443	59/9376	1.43490071546084	LEF1/CTNNA3/AXIN2/EGF	0.746220051222699
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/443	154/9376	1.23690305180147	GNAI1/GUCY1A2/PLCB4/CACNG4/NFATC2/EEF2/ADCY6/CACNA2D2/MYLK	0.660096288952314
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/443	60/9376	1.41098570353649	MAPK12/NFATC2/RAC3/SHC2	0.711174923038459
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/443	60/9376	1.41098570353649	GNAI1/GUCY1A2/PLCB4/IGF1	0.711174923038459
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/443	99/9376	1.28271427594227	ALOX12/PRKCQ/MAPK12/PLCB4/IGF1/ADCY6	0.629724213261194
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/443	99/9376	1.28271427594227	SELP/KRT19/KRT18/MASP1/C1QB/KRT23	0.629724213261194
NA	NA	hsa04382	Cornified envelope formation	12/443	217/9376	1.17040288772612	KRT19/CLDN10/KRT18/KRT8/KRT7/JUP/EPHX2/DSP/COL4A5/PKP2/KRT23/CLDN6	0.565550801205906
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/443	139/9376	1.21811715413222	KRT19/KRT18/GNAI1/PLCB4/HSP90AB1/SHC2/ADCY6/KRT23	0.57692662934508
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/443	44/9376	1.44305356043505	CHST9/B4GALNT4/TUSC3	0.655970091469655
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/443	63/9376	1.34379590812999	ALOX12/EPHX2/PTGDS/PLA2G10	0.609698337715814
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/443	26/9376	1.62806042715749	FADS2/PLA2G10	0.714119896054936
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/443	122/9376	1.21437294156829	GNAI1/MAPK12/PLCB4/IGF1/SST/SHC2/ADCY6	0.530730405868382
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/443	103/9376	1.23290012930373	PABPC5/MSI1/MSI2/FUS/PABPC1/PNN	0.529257530948047
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/443	65/9376	1.30244834172599	CGA/PLCB4/KCNN2/TRPC1	0.544877101461636
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/443	204/9376	1.14123843668393	RPS6/MAPK12/PTCH1/IGF1/FZD7/WNT5B/FZD3/DDX5/CAV1/TWIST1/FZD10	0.454176643975806
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/443	226/9376	1.12379392317066	F2R/CGA/GNAI1/PDE3A/PTCH1/RAC3/SST/POPDC3/TNNI3/ADCY6/PDE4C/SOX9	0.419499872627998
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/443	10/9376	2.11647855530474	SELENBP1	0.786614854485677
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/443	28/9376	1.51177039664624	ELOVL6/ELOVL2	0.603925904811922
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/443	106/9376	1.19800672941778	LEF1/ERG/IGF1/HSP90AB1/GSTP1/EGF	0.456543170236644
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/443	370/9376	1.08684033921054	F2R/TBXA2R/CGA/RXFP1/LEP/CTSG/TRH/PAQR9/NPW/LPAR4/APLNR/ADRA2A/SST/GRM3/GRIK5/CHRM3/P2RX1/CALCRL/CYSLTR1	0.379529236023043
NA	NA	hsa03272	Virion - Hepatitis viruses	3/443	48/9376	1.32279909706546	CLDN10/EPCAM/CLDN6	0.499283823661092
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/443	49/9376	1.29580319712535	SLC18A2/GNAI1/GRM3	0.462294524509193
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/443	89/9376	1.18903289623862	GNG11/SLC38A1/GNAI1/GAD1/ADCY6	0.399009745600536
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/443	50/9376	1.26988713318284	CKB/GAMT/CKMT1B	0.42609683769685
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/443	70/9376	1.20941631731699	HLA-G/FYN/RAC3/CAV1	0.391621790133805
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/443	91/9376	1.16290030511249	GNG11/GNAI1/PDE3A/ADCY6/PDE4C	0.347728649766453
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/443	194/9376	1.09096832747667	MYL4/TUBB2B/TPM1/MYH10/TUBB1/TNNI3/TNNT2/KIF26A/KIF6/MYO1B	0.285109222001154
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/443	12/9376	1.76373212942062	NGFR	0.589508153399586
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/443	300/9376	1.05823927765237	KIT/MECOM/ANGPT1/NGFR/MAPK12/CACNG4/TEK/RAC3/IGF1/RASGRP2/STMN1/PGF/CACNA2D2/EGF/NTF4	0.228306458766396
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/443	93/9376	1.1378916964004	CGA/MAPK12/PLCB4/ADCY6/EGR1	0.297594052776252
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/443	93/9376	1.1378916964004	CST1/GUCY1A2/PLCB4/CHRM3/ADCY6	0.297594052776252
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/443	93/9376	1.1378916964004	ITGA2B/CKS1B/COL4A5/LAMA4/LAMC1	0.297594052776252
Human Diseases	Immune disease	hsa05310	Asthma	2/443	32/9376	1.32279909706546	FCER1A/MS4A2	0.407314358392417
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/443	157/9376	1.07846041034636	PBX1/CX3CR1/MAPK12/NFATC2/ATP8A2/C1QB/RAB17/SLC2A1	0.220773695949039
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/443	158/9376	1.0716347115467	RPS6/IGF1/FZD7/WNT5B/FZD3/LRP6/DEPTOR/FZD10	0.20221927189389
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/443	75/9376	1.12878856282919	GSTM5/GSTA4/TOP2A/GSTP1	0.249362957825196
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/443	75/9376	1.12878856282919	IGF1/SIVA1/SFN/PERP	0.249362957825196
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/443	97/9376	1.09096832747667	GNG11/GNAI1/GUCY1A2/PLCB4/ADCY6	0.20054614770746
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/443	56/9376	1.13382779748468	PTCH1/LRP2/GLI2	0.223676944817272
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/443	99/9376	1.06892856328522	MAPK12/IGF1/NOTCH3/SHC2/ADCY6	0.153533050785433
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/443	248/9376	1.02410252676036	LEF1/RPS3/TUBB2B/TUBB1/WASF3/MAPK12/NCKAP1/ARPC1A/HSP90AB1/PFN2/PAK3/PODXL	0.0856622411985134
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/443	57/9376	1.11393608173934	ELOVL6/ELOVL2/FADS2	0.192133408037121
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/443	15/9376	1.41098570353649	ST6GALNAC3	0.35473174564645
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/443	79/9376	1.0716347115467	SLC18A2/SLC6A9/SNAP25/DNM1	0.142381800627044
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/443	80/9376	1.05823927765237	RPS6/IGF1/SHC2/EGF	0.116493515119555
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/443	37/9376	1.14404246232689	GAD1/ASNS	0.195492475215134
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/443	59/9376	1.07617553659563	CGA/GNAI1/ADCY6	0.130705034044549
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/443	16/9376	1.32279909706546	MIF	0.287768473155951
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/443	103/9376	1.02741677441978	CTSG/PLCB4/COL4A5/LAMA4/LAMC1	0.0623036765988528
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/443	38/9376	1.11393608173934	IGF1/SFN	0.156716591644493
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/443	17/9376	1.24498738547338	GAD1	0.225134625515133
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/443	87/9376	0.973093588645858	LEF1/RAC3/AXIN2/EGF	-0.0561461209299406
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/443	110/9376	0.9620357069567	GNAI1/MAPK12/IGF1/HSP90AB1/ADCY6	-0.0891896266548044
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/443	19/9376	1.11393608173934	GCSH	0.110702798584026
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/443	133/9376	0.954802355776575	NCR2/HLA-G/NFATC2/FYN/RAC3/SHC2	-0.116902548111169
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/443	90/9376	0.940657135690996	PRKCQ/MAPK12/NFATC2/EGF	-0.125969165986507
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/443	93/9376	0.910313357120319	PRKCQ/MAPK12/NFATC2/NOTCH3	-0.19355923693157
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/443	70/9376	0.907062237987746	PRKCQ/LEP/SLC2A1	-0.173799507108966
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/443	70/9376	0.907062237987746	GSTM5/GSTA4/GSTP1	-0.173799507108966
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/443	22/9376	0.9620357069567	HDC	-0.0396987478678914
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/443	253/9376	0.9202080675238	PRKCQ/RPS27A/WASF1/MAPK12/PLCB4/U2AF1/ARPC1A/UBB/PFN2/FNBP1L/UBA52	-0.286509641226103
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/443	71/9376	0.894286713509045	CGA/MAPK12/SHC2	-0.199108313890523
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/443	71/9376	0.894286713509045	JAM3/PTPRZ1/MAPK12	-0.199108313890523
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/443	71/9376	0.894286713509045	KIT/SLC2A1/LDHB	-0.199108313890523
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/443	254/9376	0.916585201116226	F2R/TBXA2R/SLC8A3/PLCB4/NFATC2/SLC25A6/CHRM3/P2RX1/EGF/CYSLTR1/MYLK	-0.300126100619161
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/443	142/9376	0.894286713509045	RPS27A/KLHL13/UBB/UBE2S/UBA52/UBE2C	-0.282662142261053
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/443	120/9376	0.881866064710308	NGFR/MAPK12/YWHAE/SHC2/NTF4	-0.290029688292294
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/443	73/9376	0.869785707659482	GSTM5/GSTA4/GSTP1	-0.248712383186243
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/443	73/9376	0.869785707659482	MAP1B/PSIP1/MLLT3	-0.248712383186243
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/443	98/9376	0.863868798083567	WASF1/WASF3/MARCKSL1/ARPC1A	-0.301670169310056
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/443	98/9376	0.863868798083567	PLCB4/STAR/CYP11A1/ADCY6	-0.301670169310056
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/443	122/9376	0.867409243977353	PRKCQ/MAPK12/NFATC2/FYN/PAK3	-0.328259458696084
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/443	122/9376	0.867409243977353	PLCB4/MED12L/NOTCH3/GATA4/SLC2A1	-0.328259458696084
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/443	99/9376	0.855142850628178	WASF1/WASF3/RAC3/EGF	-0.322658111690327
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/443	75/9376	0.846591422121896	PSAT1/PHGDH/ASNS	-0.297032716998136
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/443	51/9376	0.829991590315584	PLD4/PLA2G10	-0.271094000826994
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/443	76/9376	0.835452061304503	IGF1/SHC2/EGF	-0.320735182994394
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/443	195/9376	0.868298894483996	ITGA2B/SELP/CTSG/MAPK12/PLCB4/HMGB1/GP1BA/SLC25A6	-0.413857249218405
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/443	101/9376	0.838209328833561	MAPK12/PLCB4/COL4A5/EGR1	-0.364037429141668
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/443	52/9376	0.814030213578746	STAR/LRP2	-0.29945513591596
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/443	196/9376	0.863868798083567	LEF1/RPS27A/GNG11/HLA-G/MAPK12/NFATC2/UBB/UBA52	-0.428897197380414
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/443	78/9376	0.814030213578746	ISYNA1/PLCH1/PLCB4	-0.367268564104556
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/443	78/9376	0.814030213578746	PABPC5/LSM7/PABPC1	-0.367268564104556
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/443	78/9376	0.814030213578746	GNAI1/MAPK12/C1QB	-0.367268564104556
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/443	78/9376	0.814030213578746	EEF1A1/MAPK12/MARCKSL1	-0.367268564104556
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/443	103/9376	0.821933419535821	GNAI1/MAPK12/PLCB4/C1QB	-0.404650177750342
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/443	79/9376	0.803726033660028	GSTM5/GSTA4/GSTP1	-0.390115910852479
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/443	128/9376	0.826749435665914	PDE5A/PDE3A/GUCY1A2/ADCY6/PDE4C	-0.439485515801444
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/443	27/9376	0.783880946409163	GAD1	-0.250427024600358
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/443	54/9376	0.783880946409163	CGA/HLA-G	-0.354669809753784
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/443	105/9376	0.806277544877996	CLEC1B/EGR3/MAPK12/NFATC2	-0.444529060549374
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/443	224/9376	0.850370848113512	HLA-G/TERT/NFATC2/SLC25A6/RANBP1/ADCY6/EGR1/LTA/SLC2A1	-0.504743868649043
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/443	56/9376	0.755885198323122	ST6GAL2/TUSC3	-0.4080083065703
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/443	82/9376	0.774321422672466	GSTM5/GSTA4/GSTP1	-0.457072151939391
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/443	227/9376	0.83913246686091	GNG11/GNAI1/HLA-G/MAPK12/PLCB4/NFATC2/RAC3/ADCY6/CCL4L2	-0.546365604394294
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/443	180/9376	0.823074993729621	HLA-G/CFP/SRSF3/SRSF5/SRSF7/LTA/SRSF2	-0.533721656468258
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/443	298/9376	0.852273243746875	LEP/PF4/NGFR/ACVR2B/CX3CR1/PPBP/IL18R1/IL1RL1/GDF11/CXCL14/CCL4L2/LTA	-0.577113241391227
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/443	157/9376	0.808845307759773	HLA-G/E2F5/MAPK12/NFATC2/SLC25A6/GATA4	-0.537875442118834
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/443	133/9376	0.795668629813812	SLC18A2/GNG11/GNAI1/MAPK12/PLCB4	-0.52849785081125
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/443	109/9376	0.776689378093483	PRKCQ/MAPK12/NFATC2/HSP90AB1	-0.522206030524225
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/443	30/9376	0.705492851768247	PLA2G10	-0.359776186168069
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/443	31/9376	0.682735017840239	GAD1	-0.394005394747996
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/443	31/9376	0.682735017840239	GCSH	-0.394005394747996
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/443	86/9376	0.738306472780723	PAK3/SHC2/EGF	-0.542904177925685
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/443	86/9376	0.738306472780723	PLCB4/CHRM3/ADCY6	-0.542904177925685
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/443	112/9376	0.755885198323122	GNAI1/MAPK12/LAMA4/LAMC1	-0.578752241069493
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/443	138/9376	0.766840056269834	REC8/MAPK12/IGF1/YWHAE/ADCY6	-0.614459609326759
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/443	32/9376	0.661399548532731	LDHB	-0.427252823488549
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/443	32/9376	0.661399548532731	NGFR	-0.427252823488549
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/443	33/9376	0.641357137971133	AADAT	-0.459583916118077
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/443	62/9376	0.682735017840239	IGF1/ADCY6	-0.558134286317766
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/443	62/9376	0.682735017840239	HES5/NOTCH3	-0.558134286317766
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/443	90/9376	0.705492851768247	KCNN2/ADCY6/SLC2A1	-0.625160586227203
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/443	63/9376	0.671897954064997	MECOM/AADAT	-0.581866355233321
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/443	91/9376	0.697740183067497	NFATC2/RAC3/CD79B	-0.64520688250407
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/443	143/9376	0.740027466889769	CTSG/SNRPD1/SNRPD3/SSB/C1QB	-0.69761032720113
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/443	169/9376	0.75141250484192	PRKCQ/RPS27A/HMGB1/UBB/DEPTOR/UBA52	-0.726193560222189
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/443	144/9376	0.73488838725859	RELN/PLCB4/DAB1/KCND3/SLC25A6	-0.713922277573967
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/443	119/9376	0.711421363127644	MAPK12/IL18R1/DAB2IP/LTA	-0.705490809940897
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/443	268/9376	0.789730804218187	SLC18A2/RPS27A/TUBB2B/GNAI1/TUBB1/UBB/SNCAIP/SLC25A6/MT-CO3/UBA52	-0.777714818463221
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/443	36/9376	0.587910709806872	GYG2	-0.551642825639422
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/443	36/9376	0.587910709806872	ST6GALNAC3	-0.551642825639422
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/443	37/9376	0.572021231163443	MIF	-0.580846977396934
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/443	37/9376	0.572021231163443	LEF1	-0.580846977396934
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/443	149/9376	0.710227703122396	GNG11/GNAI1/MAPK12/PLCB4/ADCY6	-0.79397818745964
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/443	38/9376	0.556968040869669	IGLL1	-0.609380782317325
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/443	323/9376	0.786307822404238	HMGA2/IGF2BP1/TRIM71/DNMT3B/TPM1/ZFPM2/FZD3/HNRNPK/STMN1/FSCN1/MMP16/NOTCH3	-0.870327006453351
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/443	275/9376	0.76962856556536	TUBB2B/TUBB1/MAPK12/FYN/SLC25A6/CAV1/C1QB/MT-CO3/EGR1/LAMC1	-0.863454089094413
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/443	39/9376	0.542686809052498	GCSH	-0.637281317584497
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/443	39/9376	0.542686809052498	HLA-G	-0.637281317584497
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/443	70/9376	0.604708158658497	PAK3/SLC2A1	-0.739220804351737
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/443	41/9376	0.516214281781644	EGF	-0.691316058209292
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/443	73/9376	0.579857138439655	IGF1/EGF	-0.802482818891353
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/443	156/9376	0.678358511315622	CLDN10/EIF3E/YWHAE/EGF/CLDN6	-0.902106343016744
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/443	42/9376	0.503923465548748	AADAT	-0.717510507860506
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/443	104/9376	0.61052266018406	PLD4/ACHE/PLA2G10	-0.889407909977153
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/443	43/9376	0.492204315187149	PLA2G10	-0.743192700014214
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	18/443	480/9376	0.793679458239278	RPS27A/TUBB2B/TUBB1/MAPK12/PLCB4/FZD7/WNT5B/UBB/SNCAIP/FZD3/AXIN2/LRP6/SLC25A6/CHRM3/FUS/MT-CO3/FZD10/UBA52	-1.033366873696
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/443	105/9376	0.604708158658497	PRKCQ/CCL4L2/LTA	-0.907064236635372
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/443	105/9376	0.604708158658497	RPS27A/UBB/UBA52	-0.907064236635372
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/443	44/9376	0.48101785347835	HMGB1	-0.768387383662231
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/443	44/9376	0.48101785347835	ADCY6	-0.768387383662231
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/443	77/9376	0.549734689689543	RAC3/EGF	-0.883455262475526
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/443	77/9376	0.549734689689543	MECOM/SHC2	-0.883455262475526
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/443	214/9376	0.692306069492205	GNG11/GNAI1/HLA-G/MAPK12/NFATC2/RAC3/PAK3	-1.01395692772021
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/443	107/9376	0.59340520242189	PLCB4/SLC2A1/LDHB	-0.941946202486075
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/443	45/9376	0.470328567845498	ABCA8	-0.793117525120516
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/443	45/9376	0.470328567845498	HLA-G	-0.793117525120516
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/443	108/9376	0.587910709806872	EEF1A1/SUMO2/PNN	-0.95917759843496
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/443	46/9376	0.4601040337619	ALAS2	-0.817404475005824
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/443	217/9376	0.682735017840239	GNAI1/GSTM5/GSTA4/HSP90AB1/EPHX2/ADCY6/EGF	-1.05297197277205
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/443	138/9376	0.613472045015867	MAPK12/NFATC2/RAC3/ARPC1A	-1.01863901840826
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/443	47/9376	0.450314586235051	LDHB	-0.841268116194284
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/443	48/9376	0.440933032355154	PLCB4	-0.864726995291822
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/443	82/9376	0.516214281781644	HLA-G/HSP90AB1	-0.979822639446554
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/443	49/9376	0.431934399041784	ST6GAL2	-0.887798439763723
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/443	83/9376	0.509994832603552	ASXL3/SCML2	-0.99850575398348
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/443	83/9376	0.509994832603552	CCL4L2/ZCCHC3	-0.99850575398348
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/443	116/9376	0.547365143613295	PSAT1/PHGDH/GCSH	-1.09234627122072
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/443	227/9376	0.652658585336264	GSTM5/MAPK12/GSTA4/EPHX2/SLC25A6/MT-CO3/EGF	-1.1796998328422
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/443	205/9376	0.619457138137973	MAPK12/PLCB4/TNNI3/SLC25A6/MT-CO3/SLC2A1	-1.2267639298541
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/443	55/9376	0.38481428278268	CERS4	-1.01893192328052
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/443	90/9376	0.470328567845498	IGF1/ADCY6	-1.1243520064679
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/443	122/9376	0.520445546386412	LEP/IGF1/EEF2	-1.18724932326055
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/443	56/9376	0.377942599161561	EEF1A1	-1.03969355795787
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/443	94/9376	0.450314586235051	MAPK12/HSP90AB1	-1.19274112006034
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/443	95/9376	0.445574432695735	ANGPT1/TEK	-1.20947389797382
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/443	158/9376	0.535817355773352	CDKN1C/E2F5/YWHAE/SFN	-1.3103518436044
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/443	61/9376	0.346963697590941	SLC8A3	-1.13946147584377
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/443	191/9376	0.554051977828466	SLC18A2/GNG11/GNAI1/SHC2/PKIA	-1.38659675576672
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/443	133/9376	0.477401177888287	MAPK12/IGF1/EGF	-1.35168845621141
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/443	66/9376	0.320678568985567	CYP11A1	-1.23327883215413
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/443	66/9376	0.320678568985567	IL18R1	-1.23327883215413
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	12/443	388/9376	0.654580996486002	TUBB2B/TUBB1/PLCB4/FZD7/WNT5B/FZD3/AXIN2/LRP6/SLC25A6/CHRM3/MT-CO3/FZD10	-1.54745985875691
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/443	137/9376	0.463462457366002	DAB2IP/PTPN13/LMNB1	-1.40875915111299
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/443	67/9376	0.315892321687275	LDHB	-1.25140874460147
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/443	67/9376	0.315892321687275	PLCB4	-1.25140874460147
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/443	69/9376	0.306736022507933	SLC18A2	-1.28708478747106
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	11/443	368/9376	0.632643046422613	HNRNPA1/TUBB2B/HNRNPA2B1/TUBB1/SRSF3/MAPK12/HNRNPA3/SRSF7/PFN2/FUS/MT-CO3	-1.60098336633881
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/443	142/9376	0.447143356754523	MAPK12/NFATC2/FYN	-1.47825924564735
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/443	109/9376	0.388344689046741	MAPK12/CCL4L2	-1.43033989720235
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/443	109/9376	0.388344689046741	PRKCQ/SLC2A1	-1.43033989720235
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/443	205/9376	0.516214281781644	HLA-G/EGR3/YWHAE/HNRNPK/RANBP1	-1.55959007083942
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/443	144/9376	0.440933032355154	LEF1/MAPK12/C1QB	-1.50551821827093
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/443	72/9376	0.293955354903436	MAPK12	-1.33922144536934
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/443	73/9376	0.289928569219827	EGF	-1.35625325459646
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/443	76/9376	0.278484020434834	FADS2	-1.40637167243679
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/443	117/9376	0.361791206034998	CECR2/BCL7A	-1.54690095381429
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/443	216/9376	0.489925591505727	SELP/MAPK12/PLCB4/NFATC2/HSP90AB1	-1.68889055782493
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/443	187/9376	0.452722685626682	MAPK12/PLCB4/YWHAE/HSP90AB1	-1.68338308141835
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/443	155/9376	0.409641010704143	TUBB2B/HLA-G/TUBB1	-1.65037202318911
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/443	250/9376	0.507954853273138	HLA-G/PARD3/ARPC1A/SH3GL3/DNM1/CAV1	-1.75599614822836
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/443	157/9376	0.404422653879887	LEP/MAPK12/MT-CO3	-1.67584914922064
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/443	83/9376	0.254997416301776	EPHX2	-1.5181255546911
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/443	163/9376	0.389535930424185	EGR3/MAPK12/NFATC2	-1.75082286007915
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/443	168/9376	0.377942599161561	HMGB1/HSP90AB1/SLC25A6	-1.81172084535384
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/443	138/9376	0.306736022507933	RPS6/SHC2	-1.82699783657126
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/443	98/9376	0.215967199520892	PLCB4	-1.73743641674715
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/443	154/9376	0.274867344844771	ALAS2/PSAT1	-2.02047787492086
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/443	235/9376	0.360251668988041	RPS6/MAPK12/ADCY6/MT-CO3	-2.21174509367211
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/443	168/9376	0.251961732774374	LEP/EGF	-2.17863579796394
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/443	174/9376	0.243273397161464	HSP90AB1/TUSC3	-2.24368221750257
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/443	136/9376	0.155623423184172	EIF3H	-2.20881061258802
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/443	138/9376	0.153368011253967	MT-CO3	-2.23117724565276
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	5/443	308/9376	0.343584181055964	TUBB2B/TUBB1/PLCB4/SLC25A6/MT-CO3	-2.6084797849239
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	2/443	205/9376	0.206485712712658	HLA-G/MAPK12	-2.55806849379541
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/443	250/9376	0.253977426636569	LAPTM4B/CTSG/DEPTOR	-2.66238326712892
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/443	173/9376	0.122339800884667	SLC25A6	-2.59461890965721
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/443	181/9376	0.116932516867665	MAPK12	-2.67144445162117
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/443	449/9376	0.0942752140447546	SLC8A3/NCALD	-4.37981221212423