category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	137/1301	222/9376	4.44741744049969	RPS18/RPLP0/RPL18A/RPSA/RPS7/RPL5/RPL6/RPS4X/RPS6/RPS5/RPL10A/RPL29/RPS2/RPL8/RPS3/RPS3A/RPS26/RPL7A/RPL4/RPS13/RPL23A/RPL14/RPL13/RPL11/RPS19/RPL24/RPL18/RPS15/RPL12/RPL23/RPS27A/RPS11/RPL36/RPS16/RPL3/RPL15/RPL37/RPL35/RPL10/RPLP1/RPS8/RPL37A/RPL13A/RPS24/MRPL51/RPL32/RPL21/RPL7/RPL22/UBA52/RPL9/RPL35A/RPS9/RPLP2/RPS14/RPS27/MRPS15/MRPL52/RPS20/MRPL20/MRPL23/RPS29/RPL28/RPL27A/MRPS12/RPS25/RPL39/MRPL11/MRPL21/RPL22L1/RPL26/RPL27/MRPL12/RPS12/MRPL41/RPS23/MRPL42/RPL38/RPL17/MRPS18C/MRPL17/MRPL22/MRPL27/MRPL47/MRPL13/MRPS16/RPL19/RPL34/MRPL37/MRPL36/RPS21/MRPL32/RPL41/MRPL40/MRPL4/MRPL15/RPL26L1/MRPS25/MRPS7/MRPL14/MRPS33/MRPL35/MRPL3/RPL36AL/MRPS28/MRPL55/MRPS34/MRPL33/RPL30/MRPS6/MRPS23/MRPS26/MRPL54/MRPS2/RPL31/RPL36A/MRPS22/MRPS35/MRPL19/MRPS11/MRPL9/MRPS14/RPS10/RSL24D1/MRPS31/MRPL1/DAP3/MRPL50/MRPS9/MRPS5/MRPS18A/MRPS18B/MRPL48/MRPS10/MRPS27/MRPL24/MRPL28	20.8649778762517
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	111/1301	268/9376	2.98489107116225	TUBA1C/UQCRH/PSMA7/PSMC4/TUBB/RPS27A/TUBB6/NDUFS5/TUBA1B/NDUFA4/PARK7/CALM1/PSMA4/PSMB6/COX5A/UBA52/TXN/COX7B/TUBB4B/SNCA/HSPA5/NDUFA6/PSMB1/NDUFV2/VDAC1/UBE2L3/ADRM1/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/PSMB2/NDUFV3/VDAC2/PSMB5/PSMC5/UQCRC1/PSMA5/COX7A2/PSMA3/MT-CO2/NDUFS6/NDUFB2/NDUFB4/NDUFB3/SLC25A5/GNAI1/PSMB3/PSMD7/PSMC3/NDUFC2/UQCR10/NDUFB11/TXN2/PSMD4/PSMD11/PSMA1/PSMB7/NDUFV1/PSMD13/NDUFC1/PSMD2/PSMB4/NDUFA9/NDUFA12/PSMD14/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/PSMD1/NDUFS7/EIF2S1/NDUFA2/NDUFB10/PSMD8/COX8C/NDUFS4/NDUFS2/SOD1/NDUFB7/SLC39A4/UBA1/COX7C/NDUFB9/PSMC1/MT-CO3/NDUFB6/NDUFA13/NDUFA8/TRAP1/PSMC6/COX6C/UBE2J1/NDUFA3/PSMD6/PSMD12/SLC39A1/MAOA/PPIF/VDAC3/SDHA/PSMD3/COX7A2L/SLC39A7/SLC39A8/SDHC/MAPK9	13.2326122013356
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	109/1301	275/9376	2.85649919642233	TUBA1C/UQCRH/PSMA7/PSMC4/TUBB/CAV1/IL1B/TUBB6/IL1A/NDUFS5/TUBA1B/NDUFA4/PSMA4/PSMB6/COX5A/COX7B/TUBB4B/HSPA5/NDUFA6/PSMB1/NDUFV2/VDAC1/ADRM1/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/PSMB2/NDUFV3/VDAC2/PSMB5/PSMC5/UQCRC1/PSMA5/COX7A2/PSMA3/MT-CO2/NDUFS6/NDUFB2/NDUFB4/NDUFB3/SLC25A5/PSMB3/PSMD7/PSMC3/NDUFC2/UQCR10/TNF/NDUFB11/PSMD4/PSMD11/PSMA1/PSMB7/NDUFV1/PSMD13/NDUFC1/PSMD2/PSMB4/NDUFA9/NDUFA12/PSMD14/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/PSMD1/RAC2/NDUFS7/EIF2S1/NDUFA2/CAV2/NDUFB10/LAMC1/PSMD8/COX8C/RAC1/NDUFS4/NDUFS2/SOD1/NDUFB7/HSPA8/PRKCD/COX7C/NDUFB9/PSMC1/MT-CO3/NDUFB6/NDUFA13/NDUFA8/PIK3CB/PSMC6/FYN/COX6C/NDUFA3/PSMD6/PSMD12/PPIF/VDAC3/SDHA/PSMD3/COX7A2L/STIP1/MAPK13/SDHC/CREB5/MAPK9	12.5420802796338
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	112/1301	308/9376	2.62064146460764	TUBA1C/UQCRH/PSMA7/PSMC4/TUBB/TUBB6/NDUFS5/TUBA1B/NDUFA4/PSMA4/PSMB6/COX5A/GPX3/COX7B/TUBB4B/POLR2H/NDUFA6/PSMB1/NDUFV2/VDAC1/ADRM1/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/PSMB2/NDUFV3/PPARG/VDAC2/PSMB5/PSMC5/UQCRC1/PSMA5/COX7A2/PSMA3/MT-CO2/GPX8/NDUFS6/NDUFB2/NDUFB4/NDUFB3/SLC25A5/PSMB3/AP2S1/PSMD7/PSMC3/NDUFC2/UQCR10/NDUFB11/PSMD4/PSMD11/PSMA1/PSMB7/POLR2I/NDUFV1/PSMD13/NDUFC1/TGM2/PSMD2/POLR2L/PSMB4/NDUFA9/NDUFA12/PSMD14/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/HDAC2/PSMD1/NDUFS7/NDUFA2/NDUFB10/POLR2F/TAF4B/PSMD8/COX8C/POLR2J/NDUFS4/NDUFS2/SOD1/NDUFB7/HDAC1/COX7C/NDUFB9/PSMC1/MT-CO3/NDUFB6/NDUFA13/NDUFA8/DCTN3/PSMC6/POLR2G/TFAM/COX6C/NDUFA3/PSMD6/PSMD12/PPIF/VDAC3/SDHA/CLTB/PSMD3/COX7A2L/SDHC/DNAH14/GPX1/CREB5/MAPK9	11.6080580099529
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	121/1301	368/9376	2.36961534605487	ACTB/TUBA1C/PFN1/UQCRH/PSMA7/PSMC4/TUBB/TUBB6/ALYREF/NDUFS5/TUBA1B/NDUFA4/PSMA4/PSMB6/COX5A/GPX3/COX7B/TUBB4B/HSPA5/NDUFA6/HNRNPA1/PSMB1/NDUFV2/VDAC1/ACTG1/ADRM1/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/PSMB2/NDUFV3/PSMB5/PSMC5/UQCRC1/TOMM40/PSMA5/COX7A2/PSMA3/MT-CO2/GPX8/NDUFS6/NDUFB2/NDUFB4/NDUFB3/PSMB3/NUP37/PSMD7/PSMC3/NDUFC2/UQCR10/TNF/NDUFB11/PSMD4/PSMD11/PSMA1/PSMB7/NDUFV1/PSMD13/NDUFC1/PSMD2/PSMB4/NDUFA9/HNRNPA3/NDUFA12/PSMD14/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/PSMD1/NDUFS7/EIF2S1/NDUFA2/NDUFB10/RAE1/PSMD8/SRSF7/COX8C/BID/SEH1L/RAC1/NDUFS4/NEFH/NDUFS2/SOD1/NDUFB7/SEC13/COX7C/NDUFB9/PSMC1/MT-CO3/NDC1/NDUFB6/NDUFA13/NDUFA8/RAB8A/DCTN3/PSMC6/COX6C/NDUFA3/PSMD6/PSMD12/SRSF3/VCP/SDHA/NUP88/PSMD3/COX7A2L/SIGMAR1/NUP107/MAPK13/SDHC/DNAH14/NOS2/GPX1/NUP160/NCBP1	10.7587385812848
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	68/1301	158/9376	3.10164527773183	CCNB1/CCNE1/PTTG1/CDKN1C/CDC20/WEE1/CCNA2/YWHAE/CDK1/CCNB2/MAD2L1/MCM7/ANAPC11/MCM4/PLK1/RBX1/AURKB/CDK7/CHEK1/SMC1A/CDCA5/TFDP1/ORC6/ANAPC15/NDC80/CDT1/BUB1/MCM5/MCM3/PRKDC/TTK/BUB1B/CDC6/DBF4/TRIP13/CDC25A/PKMYT1/CDC45/YWHAG/MCM6/HDAC2/PCNA/CCND3/BUB3/ESCO2/YWHAB/PPP2R1B/MCM2/CUL1/YWHAQ/FBXO5/HDAC1/ANAPC5/E2F1/CDC26/CDK6/SKP2/ORC1/SKP1/MYC/TICRR/CDC25C/SFN/CDK2/CDK4/SMC3/CCNE2/RBL1	10.6935678379264
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	87/1301	238/9376	2.63440533784613	RPS18/RPLP0/RPL18A/RPSA/RPS7/RPL5/RPL6/RPS4X/RPS6/RPS5/RPL10A/RPL29/RPS2/RPL8/RPS3/RPS3A/RPS26/RPL7A/RPL4/RPS13/RPL23A/RPL14/RPL13/RPL11/RPS19/RPL24/RPL18/RPS15/RPL12/RPL23/RPS27A/RPS11/RPL36/RPS16/RPL3/RPL15/RPL37/RPL35/RPL10/IL1B/RPLP1/RPS8/RPL37A/RPL13A/RPS24/RPL32/RPL21/RPL7/RPL22/UBA52/RPL9/RPL35A/RPS9/RPLP2/RPS14/RPS27/RPS20/ISG15/RPS29/RPL28/RPL27A/RPS25/RPL39/C1R/RPL22L1/RPL26/RPL27/RPS12/RPS23/RPL38/RPL17/TNF/RPL19/RPL34/CCL2/RPS21/RPL41/RPL26L1/RPL36AL/RPL30/RPL31/RPL36A/RPS10/PIK3CB/RSL24D1/MAPK13/MAPK9	10.2512233210328
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	32/1301	46/9376	5.01340106272767	PSMA7/PSMC4/PSMA4/PSMB6/PSMB1/POMP/ADRM1/PSMB2/PSMB5/PSMC5/PSME2/PSMA5/PSMA3/PSMB3/PSMD7/PSMC3/PSMD4/PSMD11/PSMA1/PSMB7/PSMD13/PSMD2/PSMB4/PSMD14/PSMD1/PSMD8/PSMC1/PSME3/PSMC6/PSMD6/PSMD12/PSMD3	10.952258263613
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	65/1301	157/9376	2.98369211336698	LEP/UQCRH/IL1B/IL1A/NDUFS5/NDUFA4/COX5A/COX7B/NDUFA6/NDUFV2/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/NDUFV3/PPARG/UQCRC1/COX7A2/MT-CO2/NDUFS6/NDUFB2/NDUFB4/NDUFB3/NDUFC2/UQCR10/TNF/NDUFB11/NDUFV1/NDUFC1/NDUFA9/NDUFA12/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/NDUFS7/EIF2S1/NDUFA2/NDUFB10/COX8C/BID/RAC1/NDUFS4/NDUFS2/NDUFB7/COX7C/NDUFB9/MT-CO3/NDUFB6/NDUFA13/NDUFA8/PIK3CB/COX6C/NDUFA3/SDHA/COX7A2L/MLX/MAPK13/SDHC/CDC42/AKT1/MAPK9	10.0608623324605
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	115/1301	388/9376	2.1360254205726	GAPDH/TUBA1C/UQCRH/PSMA7/PSMC4/TUBB/IL1B/TUBB6/IL1A/NDUFS5/TUBA1B/NDUFA4/CALM1/PSMA4/PSMB6/COX5A/COX7B/TUBB4B/SNCA/NDUFA6/PSMB1/HSD17B10/NDUFV2/VDAC1/ADRM1/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/PSMB2/NDUFV3/VDAC2/PSMB5/PSMC5/UQCRC1/PSMA5/COX7A2/PSMA3/MT-CO2/NDUFS6/NDUFB2/NDUFB4/NDUFB3/SLC25A5/PSMB3/PSMD7/PSMC3/NDUFC2/UQCR10/TNF/NDUFB11/PSMD4/PSMD11/PSMA1/PSMB7/HRAS/NDUFV1/PSMD13/NDUFC1/PSMD2/WNT7A/PSMB4/NDUFA9/NDUFA12/PSMD14/COX6A1/CTNNB1/COX6B1/PTGS2/NDUFA11/NDUFS8/NDUFB1/PSMD1/ATP2A3/NDUFS7/EIF2S1/NDUFA2/NDUFB10/PSMD8/AXIN2/COX8C/BID/NDUFS4/NDUFS2/NDUFB7/SLC39A4/COX7C/NDUFB9/PSMC1/MT-CO3/NDUFB6/NDUFA13/NDUFA8/MME/PIK3CB/PSMC6/COX6C/NDUFA3/PSMD6/PSMD12/SLC39A1/PPIF/VDAC3/SDHA/PSMD3/COX7A2L/SLC39A7/FZD6/SLC39A8/SDHC/AKT1/NOS2/MAPK9	9.17329587598666
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	75/1301	205/9376	2.6366209857333	GAPDH/MMP2/UQCRH/COL1A1/SLC2A1/NDUFS5/NDUFA4/COL3A1/COX5A/COX7B/NDUFA6/NDUFV2/VDAC1/COX8A/NDUFAB1/COX5B/CYC1/UQCRFS1/NDUFV3/VDAC2/UQCRC1/COX7A2/MT-CO2/NDUFS6/NDUFB2/NDUFB4/PRKCZ/NDUFB3/SLC25A5/PPP1CA/NDUFC2/UQCR10/NDUFB11/NDUFV1/NDUFC1/PDHA1/NDUFA9/NDUFA12/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/PPP1CB/RAC2/ATP2A3/NDUFS7/NDUFA2/PPP1CC/NDUFB10/COX8C/RAC1/NDUFS4/NDUFS2/NDUFB7/PRKCD/COX7C/NDUFB9/MT-CO3/NDUFB6/NDUFA13/NDUFA8/PIK3CB/PARP1/COX6C/NDUFA3/PPIF/VDAC3/SDHA/MPC2/COX7A2L/MAPK13/SDHC/AKT1/MAPK9	9.50976358580425
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	56/1301	138/9376	2.92448395325781	UQCRH/PPA1/NDUFS5/NDUFA4/COX5A/COX7B/NDUFA6/NDUFV2/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/NDUFV3/UQCRC1/COX7A2/MT-CO2/NDUFS6/NDUFB2/NDUFB4/NDUFB3/NDUFC2/UQCR10/NDUFB11/NDUFV1/NDUFC1/NDUFA9/NDUFA12/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/NDUFS7/NDUFA2/NDUFB10/COX17/COX8C/NDUFS4/NDUFS2/NDUFB7/COX7C/NDUFB9/MT-CO3/NDUFB6/NDUFA13/NDUFA8/ATP6V1G1/COX6C/NDUFA3/ATP6V1C2/ATP6V1B1/SDHA/COX7A2L/SDHC	9.14150875297412
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	128/1301	480/9376	1.92180374071227	TUBA1C/UQCRH/PSMA7/PSMC4/TUBB/RPS27A/IL1B/TUBB6/IL1A/NDUFS5/TUBA1B/NDUFA4/PARK7/CALM1/PSMA4/PSMB6/COX5A/GPX3/UBA52/COX7B/TUBB4B/SNCA/HSPA5/NDUFA6/PSMB1/HSD17B10/NDUFV2/VDAC1/UBE2L3/ADRM1/COX8A/NDUFAB1/CYCS/COX5B/CYC1/UQCRFS1/PSMB2/NDUFV3/VDAC2/PSMB5/PSMC5/UQCRC1/TOMM40/PSMA5/COX7A2/PSMA3/MT-CO2/GPX8/NDUFS6/NDUFB2/NDUFB4/NDUFB3/SLC25A5/PSMB3/PSMD7/PSMC3/NDUFC2/UQCR10/TNF/NDUFB11/PSMD4/PSMD11/PSMA1/PSMB7/HRAS/NDUFV1/PSMD13/NDUFC1/PSMD2/WNT7A/PSMB4/NDUFA9/NDUFA12/PSMD14/COX6A1/CTNNB1/COX6B1/PTGS2/NDUFA11/NDUFS8/NDUFB1/PSMD1/ATP2A3/NDUFS7/EIF2S1/NDUFA2/NDUFB10/PSMD8/AXIN2/COX8C/BID/RAC1/NDUFS4/NEFH/NDUFS2/SOD1/NDUFB7/UBA1/COX7C/NDUFB9/PSMC1/MT-CO3/NDUFB6/NDUFA13/NDUFA8/TRAP1/RAB8A/DCTN3/PSMC6/COX6C/UBE2J1/NDUFA3/PSMD6/PSMD12/VCP/PPIF/VDAC3/SDHA/PSMD3/COX7A2L/SIGMAR1/FZD6/MAPK13/SDHC/DNAH14/NOS2/GPX1/MAPK9	8.32175103547489
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	76/1301	235/9376	2.33069815362978	RPS6/ACTB/UQCRH/NDUFS5/NDUFA4/COX5A/COX7B/NDUFA6/NDUFV2/ACTG1/COX8A/NDUFAB1/COX5B/CYC1/UQCRFS1/NDUFAF4/NDUFV3/COX20/PPARG/COA4/UQCRC1/COX7A2/MT-CO2/NDUFS6/NDUFB2/NDUFB4/NDUFB3/NDUFAF2/NDUFC2/UQCR10/NDUFB11/HRAS/NDUFV1/NDUFC1/NDUFA9/NDUFA12/COX6A1/COA3/COX6B1/NDUFA11/NDUFS8/ACTL6A/NDUFB1/ACSL4/NDUFS7/NDUFA2/NDUFB10/COA6/COX17/KDM1A/COX8C/NDUFS4/RPS6KB2/NDUFS2/NDUFB7/SMARCA4/COX16/COX7C/NDUFB9/MT-CO3/NDUFB6/NDUFA13/NDUFA8/COX6C/NDUFA3/SMARCB1/SDHA/SMARCC1/COX7A2L/RPS6KA3/MAPK13/SDHC/PRDM16/ACSL6/NDUFAF1/CREB5	8.29219777775572
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	23/1301	36/9376	4.60432146212315	RPA3/SSBP1/MCM7/POLE4/RNASEH2A/MCM4/POLD2/FEN1/MCM5/MCM3/RFC4/MCM6/RFC3/LIG1/PCNA/POLA2/MCM2/RFC2/RNASEH2C/PRIM1/RNASEH1/RFC5/POLE2	8.6966972395234
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	68/1301	227/9376	2.15885442238603	UQCRH/NDUFS5/NDUFA4/MGST3/COX5A/COX7B/NDUFA6/MGST1/NDUFV2/VDAC1/COX8A/NDUFAB1/COX5B/CYC1/UQCRFS1/NDUFV3/VDAC2/UQCRC1/COX7A2/MT-CO2/NDUFS6/ACP1/NDUFB2/NDUFB4/NDUFB3/SLC25A5/NDUFC2/UQCR10/NDUFB11/HRAS/NDUFV1/NDUFC1/NDUFA9/NDUFA12/COX6A1/COX6B1/NDUFA11/NDUFS8/NDUFB1/NDUFS7/NDUFA2/NDUFB10/COX8C/RAC1/NDUFS4/NDUFS2/SOD1/NDUFB7/PRKCD/COX7C/NDUFB9/MT-CO3/NDUFB6/NDUFA13/NDUFA8/PIK3CB/COX6C/NDUFA3/PPIF/VDAC3/SDHA/GSTA4/COX7A2L/GSTO2/MAPK13/SDHC/AKT1/MAPK9	7.09427498241699
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	43/1301	116/9376	2.67147287232633	GAPDH/ENO1/ALDOA/PKM/ACAT2/TPI1/PGAM1/GCSH/PGK1/PGP/TKT/MDH2/PHGDH/IDH2/TALDO1/HK2/PFKP/ADH5/PSAT1/GPT2/GLDC/GPI/RPIA/PDHA1/IDH1/SUCLG1/FH/ACAT1/HK1/PGD/SHMT2/IDH3G/GOT1/SDHA/GLUD1/DLAT/DLD/SDHC/PCCA/IDH3B/GOT2/ECHS1/PC	7.27069379484893
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	30/1301	75/9376	2.88270561106841	GAPDH/ENO1/ALDOA/PKM/TPI1/PGAM1/PGK1/TKT/PHGDH/IDH2/TALDO1/PFKP/PSAT1/GPT2/RPIA/IDH1/PYCR1/ARG2/ASL/BCAT2/ASNS/ASS1/SHMT2/IDH3G/GOT1/ALDH18A1/CBS/IDH3B/GOT2/PC	6.57054278230857
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	51/1301	174/9376	2.11232738742082	CALR/SSR4/PDIA6/TUSC3/P4HB/OSTC/SEC61G/PDIA3/HSPA5/PDIA4/RBX1/SSR3/LMAN2/SAR1A/SEC61B/HSP90B1/CKAP4/MAN1A2/LMAN1/DDOST/SSR2/CRYAB/DNAJB11/DAD1/ERP29/RPN2/GANAB/EIF2S1/HYOU1/KRTCAP2/DNAJA2/CUL1/SEC13/HSPA8/TMEM258/BAG2/SKP1/UBE2J1/DERL2/DNAJC10/VCP/UBXN4/DNAJC3/RAD23A/NSFL1C/STT3A/BAG1/SIL1/SEC61A1/MAPK9/SEC23B	5.94455242007325
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	55/1301	203/9376	1.95257153459067	ACTB/PGF/COL4A1/COL1A1/CAV1/COL4A2/ACTN1/FLNA/COL6A2/RAC3/FLNB/ITGA5/LAMA4/ACTG1/DIAPH1/ACTN4/COL6A3/LAMB1/PPP1CA/PARVA/COL6A1/HRAS/MYL12A/ITGA1/FLT1/MYL9/ERBB2/ILK/CTNNB1/VCL/PPP1CB/RAC2/VASP/MYL12B/PPP1CC/ITGA4/CAV2/CCND3/FLT4/LAMC1/RAC1/PAK1/LAMA5/PDGFRB/ITGB1/PDGFRA/PARVG/PIK3CB/ITGB4/FYN/COL9A3/SHC1/CDC42/AKT1/MAPK9	5.5073533638449
NA	NA	hsa04518	Integrin signaling	45/1301	154/9376	2.10587260548829	ACTB/PGF/COL4A1/COL1A1/FERMT2/COL4A2/ACTN1/FLNA/COL6A2/RAC3/FLNB/ITGA5/LAMA4/ACTG1/ACTN4/ITGAE/COL6A3/LAMB1/PARVA/COL6A1/CDH1/ITGA1/FLT1/ERBB2/ILK/CTNNB1/VCL/RAC2/ITGA4/CCND3/FLT4/LAMC1/ICAM3/RAC1/LAMA5/PDGFRB/ITGB1/PDGFRA/PARVG/PIK3CB/ITGB4/COL9A3/CDC42/AKT1/FERMT1	5.55400060051922
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	48/1301	170/9376	2.0348510195777	ACTB/TUBA1C/MYL6/CLDN7/TUBA1B/ACTN1/CD1C/EZR/CLDN4/ACTG1/ACTN4/PRKCZ/CTTN/MYH10/RDX/MYL12A/CLDN19/ACTR3/MYL9/ERBB2/CD1D/CLDN6/VASP/MYL12B/ARPC1A/PCNA/PPP2R1B/RAC1/CLDN10/ARPC2/TIAM1/RAB13/AMOTL2/ARPC5L/MYH9/ITGB1/MPDZ/ARPC1B/RAB8A/ARPC4/ARPC3/MARVELD2/PARD3/CDK4/RAB8B/CDC42/CLDN3/MAPK9	5.46537326819063
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	60/1301	233/9376	1.85581906291958	ACTB/ENO1/DSP/COL4A1/COL1A1/LMNB1/COL4A2/SDC4/TPM1/COL3A1/TPM2/TPM4/COL6A2/DSG2/DIAPH3/ITGA5/NID1/ACTG1/DIAPH1/CSRP1/TNNI2/PKP2/FHL2/MYL4/COL6A3/VCAN/JUP/LMNB2/COL5A1/MYOZ2/MYH10/COL6A1/DSC2/LBR/SPTBN1/ITGA1/MYL9/LMNA/PDLIM2/VCL/COL5A2/ITGA4/FBLN1/SYNE2/SDC1/VIM/DAG1/FLNC/MYH9/DCN/ITGB1/SGCB/ITGB4/HSPG2/CKM/COL9A3/FBLN2/ATP1A1/LMOD1/NEBL	5.30968280494072
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	42/1301	144/9376	2.10197284140405	PSMA7/PSMC4/PSMA4/PSMB6/PSMB1/VDAC1/ADRM1/CYCS/PSMB2/VDAC2/PSMB5/PSMC5/PSMA5/PSMA3/SLC25A5/PSMB3/PSMD7/PSMC3/NOP56/PSMD4/PSMD11/PSMA1/PSMB7/PSMD13/PSMD2/PSMB4/PSMD14/PSMD1/ATP2A3/PSMD8/PSMC1/PIK3CB/PSMC6/PSMD6/PSMD12/PPIF/VDAC3/PSMD3/AFG3L2/VLDLR/AKT1/MAPK9	5.34881109857689
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	29/1301	85/9376	2.45877831532305	RRM2/TYMS/NME1/DTYMK/PNP/DUT/TK1/IMPDH2/RRM1/DCTPP1/ADK/UPP1/NME1-NME2/CTPS1/AK2/APRT/ADSL/GUK1/DGUOK/ADA/HPRT1/HDDC2/UCK2/NT5C/ENPP1/ITPA/AK5/GMPS/NME2	5.42276210797789
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	12/1301	20/9376	4.32405841660261	SQLE/EBP/FDFT1/MSMO1/DHCR24/LBR/DHCR7/CYP51A1/LSS/HSD17B7/SC5D/NSDHL	5.97298686438524
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/1301	23/9376	3.76005079704575	RPA3/SSBP1/POLD2/RFC4/RFC3/LIG1/PCNA/RFC2/RFC5/MSH6/EXO1/MSH2	5.31934975651239
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/1301	30/9376	3.36315654624648	MDH2/IDH2/ACLY/PDHA1/IDH1/SUCLG1/FH/IDH3G/SDHA/DLAT/DLD/SDHC/IDH3B/PC	5.20347236265195
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1301	31/9376	3.25466762539982	SPCS3/SEC61G/HSPA5/SEC11C/SEC61B/SRP9/SPCS2/SRP14/SRPRB/SRP72/SPCS1/SEC11A/SEC61A1/SRP19	5.04692375635221
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	27/1301	87/9376	2.23658193962204	UQCRH/TPM1/TPM2/TPM4/COX5A/COX7B/COX8A/COX5B/CYC1/UQCRFS1/UQCRC1/COX7A2/MT-CO2/MYL4/UQCR10/CACNA2D4/ASPH/COX6A1/COX6B1/ATP2A3/COX8C/COX7C/MT-CO3/COX6C/COX7A2L/CACNB3/ATP1A1	4.65105060869396
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	20/1301	59/9376	2.44297085683763	GSTP1/RRM2/PRDX6/MGST3/GPX3/SRM/MGST1/IDH2/ODC1/GPX8/RRM1/GGCT/IDH1/GCLM/PGD/GPX4/CHAC2/GSTA4/GSTO2/GPX1	4.46270869417462
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	37/1301	142/9376	1.87781879594245	MMP2/ACTB/GSTP1/CAV1/IL1B/IL1A/SDC4/CALM1/MGST3/TXN/RAC3/MGST1/ACTG1/IL1R1/PRKCZ/CDH5/HSP90B1/TNF/GPC1/TXN2/CCL2/CTNNB1/RAC2/CAV2/RAC1/SUMO2/SDC1/SUMO1/ASS1/PIK3CB/BMP4/GSTA4/GSTO2/MAPK13/THBD/AKT1/MAPK9	4.23065035089567
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	24/1301	78/9376	2.21746585466801	ACTB/CAV1/ITGA5/ACTG1/CTTN/CDH1/ACTR3/ILK/CTNNB1/VCL/ARPC1A/CAV2/ARHGAP10/RAC1/ARPC2/ARPC5L/ITGB1/ARPC1B/ARPC4/ARPC3/PIK3CB/CLTB/SHC1/CDC42	4.33373489676312
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	17/1301	47/9376	2.60670188234909	LDHA/PKM/ACAT2/LDHB/MDH2/ADH5/ALDH7A1/GLO1/PDHA1/ALDH1B1/FH/ACAT1/ACYP1/DLAT/DLD/PC/ACACA	4.43220363818528
Genetic Information Processing	Transcription	hsa03040	Spliceosome	55/1301	243/9376	1.63116058239468	SNRPB/SNRPD1/SNRPF/SNRPG/ALYREF/SNRPD2/LSM4/SNRPE/LSM7/RBM8A/LSM3/SRSF9/SNRPD3/SNRPA1/HNRNPA1/LSM5/HNRNPM/HNRNPC/TXNL4A/SNRPA/PPIH/THOC7/LSM2/MAGOHB/LSM6/HNRNPA3/RBM17/SNRNP40/U2AF1/SF3A3/PPIL1/HNRNPK/MAGOH/SRSF7/RBMX/HSPA8/SF3B5/SRSF2/SF3B4/SF3B2/SNRPB2/SRSF3/U2AF2/PUF60/TCERG1/THOC3/BUD31/PRPF4/SNRNP27/SNRNP200/NCBP1/PRPF19/RBM25/SF3B3/PCBP1	4.0011911283394
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	16/1301	44/9376	2.62064146460764	HMGB1/POLE4/POLD2/FEN1/APEX1/RFC4/RFC3/LIG1/PCNA/RFC2/TDG/UNG/PARP1/RFC5/POLE2/SMUG1	4.32492858321606
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	22/1301	71/9376	2.23308181139102	LDHA/PKM/SLC16A3/PGAM1/SLC2A1/LDHB/SLC1A5/IDH2/HK2/PFKP/HRAS/PDHA1/IDH1/ERBB2/PDGFRB/PDGFRA/SLC7A5/HK1/PIK3CB/MYC/FGFR3/AKT1	4.18616072063294
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	21/1301	67/9376	2.25883648628495	GAPDH/LDHA/ENO1/ALDOA/PKM/TPI1/PGAM1/LDHB/PGK1/HK2/PFKP/ADH5/ALDH7A1/GPI/PDHA1/ALDH1B1/PGM2/HK1/PGM1/DLAT/DLD	4.15057464997142
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/1301	63/9376	2.28786159608604	RPA3/POLR2H/POLE4/RBX1/CDK7/POLD2/POLR2I/POLR2L/RFC4/RFC3/LIG1/PCNA/POLR2F/POLR2J/RFC2/POLR2G/GTF2H5/RAD23A/RFC5/POLE2	4.11668547416465
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	35/1301	138/9376	1.82780247078613	CCNB1/CCNE1/PTTG1/CDC20/YWHAE/CDK1/CCNB2/CALM1/MAD2L1/AURKA/ANAPC11/PLK1/RBX1/SMC1A/ANAPC15/PPP1CA/BUB1/PKMYT1/YWHAG/PPP1CB/PPP1CC/YWHAB/PPP2R1B/CUL1/YWHAQ/FBXO5/ANAPC5/CDC26/SKP1/CDC25C/CDK2/RPS6KA3/MAPK13/SMC3/CCNE2	3.93215205541975
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	46/1301	200/9376	1.65755572636434	GAPDH/ACTB/TUBA1C/RPS3/TUBB/IL1B/TUBB6/CLDN7/TUBA1B/EZR/CLDN4/TUBB4B/ACTG1/CYCS/NCL/MYO10/IL1R1/TMED10/BAIAP2L1/CTTN/TNF/MYH10/NCKAP1/MYO1B/CLDN19/ACTR3/CLDN6/ARPC1A/MYO6/RAC1/CLDN10/ARPC2/PAK1/ARPC5L/MYH9/ITGB1/CYFIP2/ARPC1B/ARPC4/ARPC3/FYN/MAPK13/TMBIM6/CDC42/CLDN3/MAPK9	3.77288771689801
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/1301	39/9376	2.58704349711267	GCSH/TYMS/MTHFD1L/MTHFD2/ALDH7A1/GLDC/DHFR/ATIC/MTHFD2L/MTHFD1/SHMT2/DLD/GART/CBS	3.98630454689519
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	36/1301	149/9376	1.74123157715541	NDUFS5/NDUFA4/NDUFA6/NDUFV2/NDUFAB1/NDUFV3/NDUFS6/NDUFB2/NDUFB4/NDUFB3/GNAI1/NDUFC2/NDUFB11/NDUFV1/NDUFC1/NDUFA9/NDUFA12/PTGS2/NDUFA11/GNG5/NDUFS8/NDUFB1/NDUFS7/NDUFA2/NDUFB10/NDUFS4/GNGT2/NDUFS2/NDUFB7/NDUFB9/NDUFB6/NDUFA13/NDUFA8/NDUFA3/MAPK13/MAPK9	3.66074777656383
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	10/1301	23/9376	3.13337566420479	ACAT2/FDPS/HMGCS1/HMGCR/IDI1/ACAT1/PDSS1/MVD/MVK/PMVK	4.11158060282218
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	46/1301	205/9376	1.61712753791642	HLA-G/CCNE1/CALR/PSMC4/CCNA2/PDIA3/ISG15/ADRM1/CYCS/PSMC5/HLA-DRB5/PSMD7/PSMC3/TNF/PSMD4/PSMD11/PSMD13/PSMD2/PSMD14/HDAC2/PSMD1/TNFAIP3/CCND3/PSMD8/BID/RAC1/VIM/HDAC1/E2F1/PSMC1/CDK6/SKP2/SAP30/PIK3CB/PSMC6/PSMD6/PSMD12/MYC/CD44/PSMD3/CDK2/CDK4/MAPK13/CCNE2/AKT1/MAPK9	3.58588643249317
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/1301	128/9376	1.74538816295158	RRM2/PAICS/NME1/PNP/IMPDH2/RRM1/ADK/ATIC/PGM2/NME1-NME2/AK2/APRT/ADSL/GUK1/DGUOK/ADA/HPRT1/HDDC2/NUDT5/NT5C/ENPP1/ITPA/NUDT2/AK5/PGM1/GMPS/PDE6H/GART/PDE4D/PPAT/NME2	3.40813341209188
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/1301	30/9376	2.64248014347937	TYMS/IL1B/GGH/TNF/FOLR1/ABCG2/DHFR/ATIC/SHMT2/SLC19A1/GART	3.61660341392725
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	35/1301	154/9376	1.63790091537978	NME1/MTHFD1L/GGH/MTHFD2/PDXK/QPRT/ALAS2/PSAT1/UGP2/DHFR/GCH1/ALDH1B1/NME1-NME2/UGDH/CTPS1/AK2/MTHFD2L/VKORC1L1/ADSL/MMAB/HMBS/BCAT2/MTHFD1/GCLM/RFK/PANK3/SHMT2/PTS/CPOX/AK5/DLD/PMM1/LIPT2/NME2/MOCS2	3.2037162775424
Cellular Processes	Cell motility	hsa04814	Motor proteins	42/1301	194/9376	1.56022726372259	ACTB/TUBA1C/TUBB/MYL6/TUBB6/TPM1/TUBA1B/TPM2/TPM4/DYNLL1/TUBB4B/ACTG1/KIF4A/TNNI2/MYO10/MYL4/KIF2C/KIF23/KIF15/MYH10/KIF14/KIF11/MYO1B/MYL12A/CENPE/KIFC1/TUBG1/MYL9/KIF22/KIF21A/MYL12B/MYO6/KIF20B/MYH9/DYNLT1/KIF20A/DYNC1LI1/DCTN3/KIF2A/KIF18A/KIF18B/DNAH14	3.16482340634012
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1301	116/9376	1.73956373081714	MMP2/ACTB/CLDN7/ACTN1/EZR/CLDN4/ACTG1/ACTN4/GNAI1/CDH5/MYL12A/CLDN19/THY1/MYL9/CTNNB1/VCL/CLDN6/RAC2/VASP/MYL12B/ITGA4/RAC1/CLDN10/ITGB1/PIK3CB/MAPK13/CDC42/CLDN3	3.2170078961938
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/1301	59/9376	2.07652522831199	RRM2/TYMS/NME1/DTYMK/DUT/TK1/RRM1/DCTPP1/UPP1/NME1-NME2/CTPS1/HDDC2/UCK2/NT5C/ENPP1/NUDT2/NME2	3.32939398818837
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	48/1301	232/9376	1.49105462641469	ACTB/PFN1/ACTN1/EZR/CFL1/RAC3/DIAPH3/ITGA5/ACTG1/DIAPH1/ACTN4/ITGAE/PPP1CA/MYH10/HRAS/RDX/NCKAP1/MYL12A/ACTR3/ITGA1/MYL9/VCL/PPP1CB/RAC2/MYL12B/PPP1CC/ITGA4/ARPC1A/RRAS2/RAC1/ARPC2/PAK1/TIAM1/PDGFRB/ARPC5L/MYH9/ITGB1/PDGFRA/CYFIP2/ARPC1B/ARPC4/ARPC3/PIK3CB/ITGB4/IQGAP3/FGFR3/CDC42/AKT1	3.03989590111332
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	35/1301	157/9376	1.60660344565915	HLA-G/CCNB1/CCNE1/IL1A/CCNA2/CDK1/CCNB2/CALM1/VDAC1/IGFBP3/CHEK1/VDAC2/SLC25A5/MYBL2/PPP1CA/HRAS/CDC25A/PPP1CB/PPP1CC/CCND3/FOXM1/RRAS2/EIF4EBP1/RAD1/E2F1/CDK6/PIK3CB/MYC/VDAC3/CDK2/CDK4/MAPK13/CCNE2/AKT1/RBL1	3.07656299888904
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/1301	108/9376	1.73496171036525	RAN/ALYREF/KPNA2/RBM8A/THOC7/NUP37/MAGOHB/KPNB1/RAE1/MAGOH/SEH1L/SUMO2/SRRM1/SEC13/SAP18/SUMO1/NDC1/CSE1L/IPO5/NUP88/THOC3/UPF3A/NUP107/RNPS1/NUP160/NCBP1	3.08344779709295
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	23/1301	93/9376	1.78231798533799	ACTB/ACTN1/RAC3/ACTG1/PTPRF/ACTN4/ACP1/CDH5/TCF7L2/ARHGAP29/MYL12A/CDH1/MYL9/ERBB2/CTNNB1/VCL/RAC2/MYL12B/RAC1/HEG1/FYN/PARD3/CDC42	3.04322199911701
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	23/1301	93/9376	1.78231798533799	CCNE1/CKS1B/COL4A1/COL4A2/LAMA4/CYCS/LAMB1/TRAF4/PTGS2/LAMC1/LAMA5/E2F1/ITGB1/CDK6/SKP2/CKS2/PIK3CB/MYC/CDK2/CDK4/CCNE2/AKT1/NOS2	3.04322199911701
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	11/1301	33/9376	2.40225467589034	IDH2/GPT2/PDHA1/IDH1/BCAT2/IDH3G/GOT1/DLAT/DLD/IDH3B/GOT2	3.23887146523553
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	16/1301	57/9376	2.02295130601292	ACAT2/FADS1/FADS2/SCD/FASN/ELOVL6/ACSL4/ACAT1/ELOVL2/TECR/ELOVL1/ELOVL5/ACAA1/ACSL6/ECHS1/ACACA	3.10928659215187
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1301	89/9376	1.7814472877389	COL4A1/COL1A1/COL4A2/SDC4/HMMR/COL6A2/ITGA5/LAMA4/COL6A3/LAMB1/COL6A1/ITGA1/ITGA4/LAMC1/SDC1/DAG1/LAMA5/ITGB1/ITGB4/HSPG2/CD44/COL9A3	2.97310323650185
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/1301	34/9376	2.33160012659945	POLR2H/POLR2I/POLR2L/POLR1D/POLR2F/POLR3G/POLR3K/POLR2J/POLR3H/POLR2G/POLR1E	3.12209688373772
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	42/1301	204/9376	1.48374553510874	RPS6/MMP2/ACTB/COL1A1/CAV1/SDC4/FLNA/EZR/ITGA5/ACTG1/PLAU/CTTN/PPP1CA/TNF/GPC1/HRAS/RDX/ERBB3/WNT7A/ERBB2/CTNNB1/PPP1CB/PPP1CC/CAV2/RRAS2/RAC1/LUM/SDC1/RPS6KB2/PAK1/TIAM1/GPC3/DCN/ITGB1/PIK3CB/HSPG2/MYC/CD44/FZD6/MAPK13/CDC42/AKT1	2.80383886424843
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	19/1301	75/9376	1.82571355367666	CCNB1/CCNE1/RRM2/PERP/CDK1/CCNB2/GTSE1/SIVA1/IGFBP3/CYCS/CHEK1/CCND3/BID/CDK6/SFN/SHISA5/CDK2/CDK4/CCNE2	2.88169653209123
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1301	50/9376	2.01789392774789	SRM/ODC1/ALDH7A1/ALDH1B1/P4HA2/PYCR1/ARG2/MAOA/CKM/GOT1/CKMT1B/ALDH18A1/NOS2/GOT2	2.89662877862756
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1301	110/9376	1.63790091537978	GAPDH/LDHA/RPS6/ENO1/ALDOA/SLC2A1/LDHB/TIMP1/PGK1/RBX1/HK2/EGLN3/PFKP/PDHA1/FLT1/ERBB2/EIF4EBP1/EIF4E2/RPS6KB2/HK1/PIK3CB/TF/AKT1/NOS2/IFNGR1	2.70119813367051
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/1301	56/9376	1.9303832216976	TUSC3/OSTC/MAN1A2/DDOST/DAD1/RPN2/GANAB/KRTCAP2/ALG3/MAN2A1/TMEM258/DPM3/DPM1/STT3A/ALG9	2.80285704673772
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	12/1301	41/9376	2.10929678858664	PGAM1/GCSH/PHGDH/ALAS2/PSAT1/ALDH7A1/GLDC/GCAT/SHMT2/MAOA/DLD/CBS	2.85716646370644
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/1301	27/9376	2.40225467589034	FADS1/FADS2/SCD/ELOVL6/ELOVL2/TECR/ELOVL1/ELOVL5/ACAA1	2.92872921886472
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	19/1301	78/9376	1.75549380161217	ENO1/LSM4/LSM7/LSM3/LSM5/EXOSC5/LSM2/PFKP/LSM6/EXOSC8/EXOSC3/EXOSC9/DCPS/BTG3/EXOSC4/EXOSC2/EXOSC7/HSPA9/PABPC4	2.68928269304746
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	48/1301	248/9376	1.39485755374278	GAPDH/ACTB/TUBA1C/RPS3/PFN1/TUBB/IL1B/TUBB6/ANXA2/TUBA1B/FLNA/TXN/DYNLL1/TUBB4B/ACTG1/CYCS/TCF7L2/HSP90B1/TNF/TXN2/HRAS/NCKAP1/MYL12A/ACTR3/MYL9/CTNNB1/MYL12B/ARPC1A/MYO6/RAC1/ARPC2/PAK1/ARPC5L/DYNLT1/CYFIP2/ARPC1B/DYNC1LI1/ARPC4/CSE1L/ARPC3/PIK3CB/SKP1/DCTN3/MYC/MAPK13/CDC42/AKT1/MAPK9	2.52948143514316
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/1301	37/9376	2.14255146768598	HK2/GPI/UGP2/GNPNAT1/PGM2/UGDH/HK1/GALK1/PGM1/UAP1/PMM1	2.79498491225263
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	8/1301	23/9376	2.50670053136383	GPT2/ARG2/ASL/ASS1/GOT1/GLUD1/NOS2/GOT2	2.90381144913198
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1301	38/9376	2.08616853432582	HK2/GPI/UGP2/GNPNAT1/PGM2/UGDH/HK1/GALK1/PGM1/UAP1/PMM1	2.69286822534916
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	20/1301	86/9376	1.6759916343421	ACTB/DSP/DSG2/ITGA5/ACTG1/PKP2/TCF7L2/JUP/CACNA2D4/DSC2/ITGA1/LMNA/CTNNB1/ATP2A3/ITGA4/DAG1/ITGB1/SGCB/ITGB4/CACNB3	2.52775926577338
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	23/1301	103/9376	1.60927740423722	COL4A1/COL1A1/IL1B/COL4A2/COL3A1/ACTN1/CD1C/CXCL1/LAMA4/IL1R1/ACTN4/SERPINB9/LAMB1/TNF/PRDX1/CD1D/VCL/LAMC1/ARG2/LAMA5/PIK3CB/CXCL2/NOS2	2.49560918603254
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1301	54/9376	1.86842030347027	LDHA/LDHB/SRM/MDH2/PHGDH/DNMT1/CISD1/PSAT1/BCAT2/GCLM/GOT1/ADI1/CBS/GOT2	2.56877058926272
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/1301	253/9376	1.36729119892573	ACTB/PFN1/RPS27A/IL1B/ACTN1/UBA52/CBX3/BNIP3/ITGA5/VDAC1/ACTG1/DIAPH1/RBX1/CYCS/HK2/IL1R1/ACTN4/CTTN/TNF/MYL12A/ACTR3/MYL9/ILK/VCL/U2AF1/MYL12B/ARPC1A/RAC1/CUL1/ARPC2/RPS6KB2/PRKCD/UBE2N/ARPC5L/ITGB1/HK1/ARPC1B/ARPC4/ARPC3/PIK3CB/SKP1/FNBP1L/UBE2V2/CD44/MAPK13/CDC42/AKT1/MAPK9	2.37714112776752
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/1301	44/9376	1.96548109845573	TUSC3/OSTC/MAN1A2/DDOST/DAD1/RPN2/KRTCAP2/ALG3/MAN2A1/TMEM258/STT3A/ALG9	2.57653336068194
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	19/1301	82/9376	1.66985995763109	GSTP1/RRM2/NME1/MGST3/MGST1/DUT/TK1/IMPDH2/RRM1/UPP1/NME1-NME2/TPMT/HPRT1/UCK2/ITPA/GSTA4/GSTO2/GMPS/NME2	2.44535902474711
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/1301	31/9376	2.09228633061417	ALDOA/TKT/TALDO1/PFKP/GPI/RPIA/PGM2/PGD/PGM1	2.44501041688478
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1301	31/9376	2.09228633061417	ACAT2/GCSH/PGP/MDH2/GLDC/ACAT1/SHMT2/DLD/PCCA	2.44501041688478
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	22/1301	103/9376	1.5393088214443	ALYREF/RBM8A/PPP1CA/MAGOHB/PPP1CB/GSPT1/PPP1CC/MAGOH/SSU72/PPP2R1B/SRRM1/NUDT21/DAZAP1/SAP18/CSTF3/CPSF3/PPP2R3A/PAPOLA/UPF3A/RNPS1/PABPC4/NCBP1	2.20901684445325
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	42/1301	224/9376	1.35126825518832	HLA-G/CCNE1/PTTG1/RAN/CALR/RANBP1/CDC20/SLC2A1/FDPS/CCNA2/CCNB2/MAD2L1/ANAPC11/VDAC1/CHEK1/VDAC2/IL1R1/HLA-DRB5/SLC25A5/ANAPC15/TNF/HRAS/BUB1B/CCND3/BUB3/TSPO/NFYB/ANAPC5/E2F1/CDC26/MSX2/FOSL1/PIK3CB/MYC/VDAC3/IL2RB/CDK2/CDK4/CCNE2/AKT1/CREB5/MAPK9	2.13578694682962
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1301	42/9376	1.88748581677098	VDAC2/ACSL4/CP/GCLM/SLC7A11/TF/GPX4/VDAC3/SLC39A8/ACSL6/PCBP1	2.31369010414591
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/1301	37/9376	1.94777406153271	GPT2/ADSL/NIT2/ASL/ASNS/ASS1/GOT1/GLUD1/PPAT/GOT2	2.31850754835
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1301	110/9376	1.5068688421494	CCNB1/CCNA2/CDK1/CCNB2/MAD2L1/AURKA/ANAPC11/PLK1/GNAI1/ANAPC15/BUB1/CDC25A/PKMYT1/KIF22/ANAPC5/CDC26/PIK3CB/CDC25C/CDK2/RPS6KA3/MAPK13/AKT1/MAPK9	2.14634144178105
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	28/1301	142/9376	1.42105206179429	UBE2C/RPS27A/CDC20/UBA52/ANAPC11/UBE2S/UBE2L3/RBX1/ANAPC15/SAE1/RNF7/UBE2M/BRCA1/CUL1/UBA1/ANAPC5/UBE2N/CDC26/MID1/UBE2Q2/UBE2K/SKP2/UBA2/SKP1/UBE2J1/CBLB/HUWE1/PRPF19	2.02926168955275
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/1301	101/9376	1.4984360849613	MMP2/COL4A1/COL1A1/IL1B/COL4A2/IL1A/COL3A1/DIAPH1/PRKCZ/TNF/HRAS/CCL2/RAC1/PRKCD/PIK3CB/CDK4/MAPK13/THBD/CDC42/AKT1/MAPK9	2.02146499336547
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1301	19/9376	2.27582021926453	GCSH/GLDC/PDHA1/DLAT/DLD/LIPT2	2.23434888405805
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	30/1301	157/9376	1.37708866770784	ACTB/BIRC5/YWHAE/BMP2/ID1/ACTG1/PRKCZ/TCF7L2/PPP1CA/TEAD1/WNT7A/CDH1/YWHAG/CTNNB1/YAP1/PPP1CB/PPP1CC/CCND3/WWTR1/DLG5/AXIN2/YWHAB/PPP2R1B/YWHAQ/TEAD4/BMP4/MYC/PARD3/TEAD3/FZD6	1.91251310996046
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1301	51/9376	1.69570918298142	ACTB/SEC61G/KDELR2/PDIA4/ACTG1/SEC61B/KDELR1/ATP6V1G1/ATP6V1C2/ATP6V1B1/KDELR3/SEC61A1	1.99959215691964
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1301	98/9376	1.47076816891245	CFL1/MYO10/ACTR3/RAC2/VASP/ARPC1A/RAC1/ARPC2/RPS6KB2/PAK1/PRKCD/ARPC5L/ARPC1B/ARPC4/ARPC3/PIK3CB/ASAP3/MARCKSL1/CDC42/AKT1	1.88038147932414
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	22/1301	110/9376	1.4413528055342	ID3/BMP2/ID1/LRRC32/RBX1/TFDP1/TNF/GREM2/HDAC2/ID4/PPP2R1B/CUL1/RPS6KB2/HDAC1/DCN/SKP1/TF/BMP4/MYC/BAMBI/FST/RBL1	1.86891309583631
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/1301	41/9376	1.7577473238222	RPA3/SSBP1/POLD2/BRCA1/BARD1/RAD51/BLM/XRCC2/TOPBP1/XRCC3	1.95169612304255
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1301	70/9376	1.54430657735808	HLA-G/ACTB/CAV1/RAC3/ACTG1/CYCS/HLA-DRB5/RAC2/BID/RAC1/DAG1/EIF4G1/SGCB/FYN/CD55	1.83469593706636
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/1301	48/9376	1.65155008967461	ACAT2/HMGCS1/HSD17B10/ALDH7A1/ALDH1B1/ACAT1/BCAT2/ACAA1/DLD/PCCA/ECHS1	1.81646560916923
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1301	43/9376	1.6759916343421	ACAT2/ADH5/ALDH7A1/ALDH1B1/ACSL4/ACAT1/ECI1/ACAA1/ACSL6/ECHS1	1.78327342362174
NA	NA	hsa04517	IgSF CAM signaling	50/1301	299/9376	1.20514448623261	ACTB/TUBA1C/TUBB/MYL6/TUBB6/TUBA1B/ACTN1/EZR/DYNLL1/TUBB4B/ITGA5/CD48/ACTG1/PTPRF/IL1RAP/ACTN4/MYH10/RDX/MYL12A/PTPRS/SPTBN1/CDH1/ACTR3/MYL9/CTNNB1/VCL/MYL12B/ITGA4/ARPC1A/ICAM3/RAC1/ARPC2/PAK1/ARPC5L/MYH9/ITGB1/MPDZ/ARPC1B/ARPC4/ARPC3/PIK3CB/FYN/PARD3/ROBO1/MAPK13/NLGN2/CDC42/AKT1/NPHS1/MAPK9	1.44702920393423
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1301	75/9376	1.4413528055342	GSTP1/BIRC5/TOP2A/MGST3/MGST1/CYCS/ERBB2/BRCA1/BID/PIK3CB/GSTA4/GSTO2/MSH6/MSH2/AKT1	1.54029789564856
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	55/1301	333/9376	1.19030637093666	HLA-G/CCNE1/PKM/COL4A1/COL1A1/COL4A2/CCNA2/COL6A2/ITGA5/LAMA4/ISG15/HEY1/PRKCZ/COL6A3/TCF7L2/LAMB1/TNF/COL6A1/HRAS/WNT7A/ITGA1/TUBG1/CTNNB1/PTGS2/HDAC2/ITGA4/CCND3/LAMC1/AXIN2/EIF4EBP1/PPP2R1B/RPS6KB2/LAMA5/HDAC1/PDGFRB/E2F1/PSMC1/ITGB1/CDK6/PIK3CB/ITGB4/ATP6V1G1/ATP6V1C2/PARD3/PPP2R3A/ATP6V1B1/COL9A3/CDK2/CDK4/FZD6/CCNE2/CDC42/AKT1/RBL1/CREB5	1.41929345430506
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1301	13/9376	2.21746585466801	FEN1/XRCC5/XRCC6/PRKDC	1.7630879417084
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1301	94/9376	1.38001864359658	IL1B/CXCL1/HSP90B1/TNF/CCL2/MAPK6/TRAF4/PTGS2/TNFAIP3/ANAPC5/S100A9/FOSL1/CXCL2/ELAVL1/MAPK13/CCL20/IL17RA/MAPK9	1.486281490215
NA	NA	hsa04519	Cadherin signaling	65/1301	404/9376	1.15950411336291	KRT19/ACTB/KRT18/DSP/KRT7/LIMA1/KRT8/YWHAE/ACTN1/DSG2/RAC3/KRT10/ACTG1/KRT23/ACTN4/PKP2/CDH5/TCF7L2/PPP1CA/JUP/HRAS/NCKAP1/DSC2/MYO1B/TEAD1/WNT7A/CDH1/ACTR3/YWHAG/ERBB2/CTNNB1/VCL/YAP1/PPP1CB/RAC2/VASP/PPP1CC/ARPC1A/PKP3/WWTR1/FLT4/AXIN2/RRAS2/YWHAB/RAC1/ARPC2/YWHAQ/VIM/PDGFRB/AMOTL2/ARPC5L/PDGFRA/MPDZ/CYFIP2/ARPC1B/TEAD4/ARPC4/ARPC3/DSC3/TEAD3/FZD6/MAPK13/CDC42/CDH11/MAPK9	1.31543974136639
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1301	36/9376	1.60150311726023	HK2/GPI/UGP2/PGM2/HK1/ENPP1/PGM1/PYGL	1.45133849863667
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1301	54/9376	1.46804452415521	UBE2T/RPA3/FANCI/FANCD2/BRCA1/FANCB/RAD51/BLM/FANCE/USP1/RMI2	1.38446671883522
NA	NA	hsa04981	Folate transport and metabolism	7/1301	31/9376	1.62733381269991	TYMS/FOLR1/ABCG2/DHFR/MTHFD1/SHMT2/SLC19A1	1.40424508109781
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/1301	61/9376	1.41772407101725	MT1E/MT1G/MT1F/MT1H/MT2A/MT1X/SLC6A19/SLC39A4/ATP2B3/TF/ATP1A1/MT1A	1.31375992722601
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	24/1301	138/9376	1.25335026568192	ACTB/IL1B/RAC3/ITGA5/ACTG1/TNF/CCL2/ACTR3/RAC2/ITGA4/ARPC1A/RAC1/ARPC2/ARPC5L/ITGB1/ARPC1B/ARPC4/ARPC3/PIK3CB/RPS6KA3/MAPK13/CDC42/AKT1/MAPK9	1.20344140431984
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	19/1301	106/9376	1.29177845779009	CCNE1/GSTP1/PLAU/TCF7L2/HSP90B1/FOLR1/HRAS/ERBB2/CTNNB1/SPINT1/PDGFRB/E2F1/PDGFRA/PIK3CB/SLC19A1/CDK2/CCNE2/AKT1/CREB5	1.21260487814844
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1301	87/9376	1.32538189014639	BIRC5/RAC3/CYCS/TCF7L2/HRAS/CTNNB1/RAC2/AXIN2/RAC1/RPS6KB2/PIK3CB/MYC/MSH6/MSH2/AKT1/MAPK9	1.22383126401307
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1301	32/9376	1.57647963105304	HK2/PFKP/UGP2/PGM2/HK1/GALK1/PGM1	1.31112941877955
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1301	32/9376	1.57647963105304	LDHA/LDHB/SUCLG1/DLD/PCCA/ECHS1/ACACA	1.31112941877955
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1301	63/9376	1.37271695765162	ACAT2/EZH2/ALDH7A1/ALDH1B1/PLOD1/PLOD2/ACAT1/SMYD3/SUV39H1/DLD/PRDM16/ECHS1	1.19140013973735
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1301	16/9376	1.80169100691776	MIF/MAOA/GOT1/GOT2	1.28819645535745
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/1301	77/9376	1.31032073230382	RALBP1/RAC3/ERBB2/RAC2/RAC1/RPS6KB2/E2F1/RAD51/CDK6/PIK3CB/CDK4/CDC42/AKT1/MAPK9	1.09746594107776
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/1301	156/9376	1.20112733794517	LDLR/CLDN7/YWHAE/CLDN4/CYCS/TNF/HRAS/CLDN19/YWHAG/CTNNB1/CLDN6/EIF2S1/YWHAB/BID/PPP2R1B/CLDN10/YWHAQ/E2F1/PSME3/CDK6/PIK3CB/MYC/CDK2/CDK4/AKT1/CLDN3	1.01676588254822
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1301	28/9376	1.54430657735808	ELOVL6/ELOVL2/TECR/ELOVL1/ELOVL5/ECHS1	1.15775393862865
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1301	41/9376	1.40619785905776	MMP2/HRAS/CDH1/ERBB2/E2F1/MYC/FGFR3/CDK4	1.04622578237866
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	33/1301	205/9376	1.16011323372265	HLA-G/CCNE1/PKM/RANBP1/CDC20/CCNA2/YWHAE/CDK1/ACTN1/CHEK1/ACTN4/HRAS/YWHAG/HDAC2/HNRNPK/CCND3/GTF2A2/YWHAB/RAC1/YWHAQ/HDAC1/PSMC1/CDK6/SKP2/PIK3CB/VDAC3/CDK2/CDK4/CCNE2/MRPS18B/CDC42/RBL1/CREB5	0.930355294802
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1301	35/9376	1.4413528055342	ALDOA/TPI1/HK2/PFKP/HK1/KHK/PMM1	1.04996844843967
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1301	99/9376	1.23752513606472	ACTB/TPM1/TPM2/TPM4/ITGA5/ACTG1/TNF/CACNA2D4/ITGA1/LMNA/ATP2A3/ITGA4/DAG1/ITGB1/SGCB/ITGB4/CACNB3	0.953622337861146
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1301	29/9376	1.49105462641469	TEAD1/YAP1/WWTR1/PAK1/TEAD4/TEAD3	1.06303045190304
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1301	48/9376	1.35126825518832	LDLR/CLDN7/CLDN4/CLDN19/CLDN6/CLDN10/HSPG2/EPCAM/CLDN3	0.979305682332293
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/1301	227/9376	1.14292292949849	HLA-G/CALR/CCL3L1/IL1B/CCL4L1/CALM1/CCL3L3/PDIA3/RAC3/CYCS/CCL4L2/IL1R1/GNAI1/TNF/HRAS/CCL2/CCL4/CTNNB1/PTGS2/GNG5/RAC2/CCL3/EIF4EBP1/BID/RAC1/GNGT2/RPS6KB2/E2F1/PDGFRA/CDK6/PIK3CB/MYC/CDK4/MAPK13/AKT1/CREB5	0.874945587269903
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	34/1301	214/9376	1.1449998922468	HLA-G/CCNB1/CALR/WEE1/CDK1/CCNB2/CALM1/CFL1/PDIA3/RAC3/RBX1/CYCS/CHEK1/GNAI1/TNF/APOBEC3B/HRAS/RNF7/GNG5/RAC2/BID/RAC1/AP1M2/CUL1/GNGT2/RPS6KB2/PAK1/PIK3CB/SKP1/CDC25C/MAPK13/AP1S1/AKT1/MAPK9	0.861256362839124
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1301	18/9376	1.60150311726023	FASN/ACSL4/ACSL6/ACACA	1.0252638281237
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	55/1301	362/9376	1.09495033569587	CCNE1/RPS6/PGF/COL4A1/COL1A1/COL4A2/YWHAE/COL6A2/IL7R/ITGA5/LAMA4/EFNA1/COL6A3/HSP90B1/LAMB1/COL6A1/HRAS/ERBB3/ITGA1/FLT1/YWHAG/ERBB2/GNG5/BRCA1/ITGA4/CCND3/FLT4/LAMC1/YWHAB/EIF4EBP1/EIF4E2/PPP2R1B/RAC1/GNGT2/RPS6KB2/YWHAQ/LAMA5/PDGFRB/ITGB1/PDGFRA/CDK6/PIK3CB/ITGB4/MYC/PPP2R3A/FGFR3/COL9A3/OSMR/IL2RB/CDK2/CDK4/CDC37/CCNE2/AKT1/CREB5	0.739511673484526
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1301	50/9376	1.29721752498078	HBA2/HBA1/IL1B/GYPA/GYPB/TNF/CCL2/SDC1/HBB	0.845794255081783
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1301	105/9376	1.16680941400388	ACTB/TPM1/TPM2/TPM4/ITGA5/ACTG1/TNF/CACNA2D4/ITGA1/LMNA/ATP2A3/ITGA4/DAG1/ITGB1/SGCB/ITGB4/CACNB3	0.689929852313598
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1301	52/9376	1.24732454325075	CGA/LDLR/CYP11A1/HSD3B1/PTGS2/HSD17B7/HSD17B1/CYP19A1/CYP2J2	0.717828630440152
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1301	59/9376	1.22148542841882	TCF7L2/HRAS/CDH1/ERBB2/ILK/CTNNB1/AXIN2/PIK3CB/MYC/AKT1	0.684993007553767
NA	NA	hsa04382	Cornified envelope formation	33/1301	217/9376	1.09595950651218	KRT19/S100A11/KRT18/DSP/KRT7/COL4A1/KRT8/COL4A2/CLDN7/S100A6/DSG2/CLDN4/PRSS8/KRT10/KRT23/PKP2/JUP/S100A4/CLDN19/PADI1/CLDN6/PKP3/PPP2R1B/CLDN10/LAMA5/PCSK6/S100A9/S100A5/ITGB4/ELOVL1/PPP2R3A/S100A13/CLDN3	0.574046223610981
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/1301	155/9376	1.11588604299422	HLA-G/ACTB/TUBA1C/CALR/TUBB/CLEC7A/TUBB6/TUBA1B/SEC61G/TUBB4B/ITGA5/ACTG1/C1R/HLA-DRB5/SEC61B/MRC1/RAC1/ITGB1/DYNC1LI1/ATP6V1G1/ATP6V1C2/ATP6V1B1/CORO1A/SEC61A1	0.583930275297362
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1301	80/9376	1.17109915449654	RPS6/HRAS/ERBB3/ERBB2/EIF4EBP1/EIF4E2/RPS6KB2/PDGFRB/PDGFRA/PIK3CB/FGFR3/SHC1/AKT1	0.616875923798489
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1301	47/9376	1.22668323875251	PKM/HK2/PRKCZ/TNF/PRKCD/HK1/PIK3CB/MAPK9	0.625322150021743
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1301	21/9376	1.37271695765162	ALDH1B1/BCAT2/PANK3/ENPP1	0.686309364724181
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	15/1301	95/9376	1.13791010963227	CCL3L1/IL1B/IL1A/CCL3L3/CXCL1/HLA-DRB5/TNF/CCL2/FLT1/CCL3/ATP6V1G1/CXCL2/ATP6V1C2/ATP6V1B1/CCL20	0.542267455778487
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1301	109/9376	1.12399071991199	SLC2A1/PTPRF/PRKCZ/PPP1CA/TNF/PPP1CB/PPP1CC/RPS6KB2/PRKCD/PIK3CB/SLC27A6/MLX/RPS6KA3/PYGL/AKT1/CREB5/MAPK9	0.522619812794744
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1301	75/9376	1.15308224442736	CGA/ASGR2/GPX3/HSPA5/PDIA4/GPX8/HSP90B1/TTF2/ATP1A1/TTR/GPX1/CREB5	0.534248918316557
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1301	15/9376	1.4413528055342	ACP1/AK2/AK5	0.686631019660328
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1301	28/9376	1.2869221477984	GGH/DHFR/GCH1/PTS/MOCS2	0.610290708419745
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	29/1301	193/9376	1.08288164146352	CCL3L1/CCL4L1/CCL3L3/RAC3/CXCL1/CXCL14/CCL4L2/PRKCZ/GNAI1/CCR7/HRAS/CCL2/CCL4/GNG5/RAC2/CCL3/RAC1/GNGT2/PAK1/TIAM1/PRKCD/PIK3CB/CXCL2/PARD3/SHC1/CCL20/CDC42/AKT1/GRK6	0.466979404458272
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1301	62/9376	1.16238129478565	HRAS/CRYAB/CLPB/HDAC2/RPS6KB2/SOD1/HSPA8/HDAC1/PIK3CB/AKT1	0.514892717064912
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1301	117/9376	1.108732927334	ACTB/ACTG1/CDK2AP2/RUVBL1/MORF4L2/ACTL6A/RBBP7/HDAC2/MORF4L1/RUVBL2/MBD2/SMARCA4/HDAC1/MTA3/SMARCB1/INO80C/SMARCC1/BAZ1A	0.475034323021824
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	21/1301	138/9376	1.09668148247168	RPS6/CALM1/PTPRF/FASN/HK2/PRKCZ/PPP1CA/HRAS/PPP1CB/PPP1CC/EIF4EBP1/EIF4E2/RPS6KB2/HK1/PIK3CB/CBLB/SHC1/PYGL/AKT1/MAPK9/ACACA	0.459247590383496
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1301	42/9376	1.20112733794517	ACAT2/ALDH7A1/ALDH1B1/ACAT1/MAOA/DLD/ECHS1	0.52434227418987
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1301	83/9376	1.12877026939426	PRDX5/IDH2/IDH1/PRDX1/ACSL4/SOD1/MPV17L2/ECH1/ACAA1/MVK/PMVK/ACSL6/NOS2	0.472965761525541
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1301	56/9376	1.15822993301856	IL1B/BNIP3/CXCL1/CYCS/SAR1A/TNF/HSPA8/CXCL2/VCP	0.476680869154852
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/1301	105/9376	1.0981735661213	RPS27A/UBA52/BNIP3/TOMM20/TOMM40/PHB2/HRAS/EIF2S1/RRAS2/E2F1/MTX2/VCP/HUWE1/MTX1/SAMM50/MAPK9	0.406049468968169
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/1301	112/9376	1.09388382562864	LDLR/LAMA4/CYCS/HLA-DRB5/GNAI1/LAMB1/TNF/LAMC1/HSPA8/LAMA5/ITGB1/PPIF/MAPK13/AKT1/NOS2/MAPK9/IFNGR1	0.401193175900633
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/1301	78/9376	1.108732927334	IL1B/IL1A/CALM1/CFL1/ITGA5/C1R/GNAI1/TNF/ITGB1/MAPK13/NOS2/MAPK9	0.387049607845533
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1301	23/9376	1.25335026568192	CA2/CA4/GLUD1/ATP1A1	0.48827314175157
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1301	37/9376	1.16866443691963	MIF/ADH5/GSTZ1/MAOA/GOT1/GOT2	0.412598092739488
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1301	37/9376	1.16866443691963	HBA2/HBA1/IL1B/LAMA4/TNF/HBB	0.412598092739488
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1301	37/9376	1.16866443691963	PPARG/TCF7L2/HRAS/CDH1/CTNNB1/MYC	0.412598092739488
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/1301	170/9376	1.05981823936339	ACTB/GSTP1/MGST3/MGST1/ACTG1/TCF7L2/HRAS/WNT7A/CTNNB1/ACTL6A/AXIN2/RPS6KB2/SMARCA4/E2F1/CDK6/PIK3CB/MYC/SMARCB1/GSTA4/SMARCC1/SHC1/GSTO2/CDK4/FZD6/AKT1	0.315918910241098
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1301	44/9376	1.14653064076584	CDK7/TAF9/TAF4B/GTF2A2/GTF2H5/TAF11/TAF12	0.391039332514296
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1301	100/9376	1.08101460415065	IL1B/IL1A/GYPA/CD1C/IL7R/ITGA5/IL1R1/HLA-DRB5/TNF/ITGA1/CD1D/ITGA4/MME/CD44/CD55	0.32691584106968
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1301	17/9376	1.27178188723606	CA2/CA4/GLUD1	0.450176964107284
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1301	17/9376	1.27178188723606	MYH10/DAG1/MYH9	0.450176964107284
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1301	122/9376	1.06329305326294	LEP/CCNA2/SCD/HMGCR/FASN/PPARG/PFKP/EIF4EBP1/PPP2R1B/RPS6KB2/RAB8A/PIK3CB/EEF2/PPP2R3A/ELAVL1/AKT1/CREB5/ACACA	0.282438720454094
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/1301	137/9376	1.05208233980599	ACTB/TUBA1C/BIRC5/LMNB1/TUBA1B/ACTG1/CYCS/TNF/LMNB2/HRAS/CTSV/LMNA/EIF2S1/BID/ENDOG/PIK3CB/PARP1/PTPN13/AKT1/MAPK9	0.246485461185216
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1301	60/9376	1.08101460415065	RAC3/HRAS/PTGS2/RAC2/RAC1/PIK3CB/MAPK13/CDC42/AKT1	0.252683695923179
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1301	46/9376	1.09668148247168	ALAS2/MMAB/CP/HMBS/FXN/CPOX/HCCS	0.263836219901512
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	15/1301	103/9376	1.04952874189384	COL4A1/COL1A1/COL4A2/COL3A1/COL6A2/COL21A1/SLC1A5/COL6A3/COL5A1/COL6A1/COL5A2/SLC6A19/MME/COL9A3/ATP1A1	0.202870453398224
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/1301	103/9376	1.04952874189384	CALR/CCL3L1/IL1B/CCL3L3/GNAI1/TNF/CCL2/CCL3/PPP2R1B/PIK3CB/MAPK13/AKT1/NOS2/MAPK9/IFNGR1	0.202870453398224
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1301	18/9376	1.20112733794517	PRDX1/MMAB/MMADHC	0.342822137616259
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/1301	125/9376	1.03777401998463	RAC3/PRKCZ/GNAI1/TNF/HRAS/RAC2/ORMDL2/SPTSSA/BID/PPP2R1B/RAC1/CERS5/PIK3CB/FYN/PPP2R3A/MAPK13/AKT1/MAPK9	0.170650235816989
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1301	83/9376	1.04194178713316	IL1B/CCL4L1/POLR2H/CCL4L2/CCL4/POLR2L/POLR1D/POLR2F/POLR3G/POLR3K/POLR3H/PCBP1	0.154049761520976
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1301	76/9376	1.04308426716291	FADS2/HMGCS1/SCD/DBI/PPARG/ILK/ACSL4/PLIN2/SLC27A6/ACAA1/ACSL6	0.15136903878461
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1301	76/9376	1.04308426716291	CALM1/CAMK1/HRAS/PDGFRB/E2F1/PDGFRA/CDK6/PIK3CB/SHC1/CDK4/AKT1	0.15136903878461
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1301	69/9376	1.04445855473493	RAC3/TNF/HRAS/RAC2/RAC1/PIK3CB/FYN/MAPK13/AKT1/MAPK9	0.148774346020174
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1301	26/9376	1.108732927334	PLA2G2A/FADS2/PLA2G10/ACAA1	0.222840933915329
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/1301	70/9376	1.02953771823872	SLC2A1/RBX1/EGLN3/HRAS/FH/RAC1/PAK1/PIK3CB/CDC42/AKT1	0.0995628822010998
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1301	34/9376	1.05981823936339	RBX1/NFIL3/CUL1/SKP1/BHLHE40	0.140251067100778
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/1301	136/9376	1.00682732739522	CCNE1/IL1B/IL1A/CYCS/TNFAIP3/EIF2S1/CCND3/BID/HSPA8/CDK6/PIK3CB/CBLB/IL2RB/CDK2/CDK4/CCNE2/EIF3H/AKT1/MAPK9	0.0321912038994741
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/1301	78/9376	1.01633851672284	IL1B/IL1A/HLA-DRB5/TNF/PTGS2/ITGA4/ITGB1/MAPK13/MARCKSL1/NOS2/IFNGR1	0.0581591671024009
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1301	27/9376	1.06766874484015	ACAT2/HMGCS1/ACAT1/ECHS1	0.141331980291967
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/1301	100/9376	1.00894696387394	CCL3L1/CCL4L1/CCL3L3/CXCL1/CXCL14/CCL4L2/CCR7/TNF/CCL2/CCL4/CCL3/CXCL2/IL2RB/CCL20	0.0361034192604468
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1301	71/9376	1.01503718699592	CXCL1/RAC1/PAK1/ATP6V1G1/CXCL2/ATP6V1C2/ATP6V1B1/MAPK13/CDC42/MAPK9	0.0510493958872982
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1301	20/9376	1.08101460415065	UGP2/UGDH/UAP1	0.145574808191788
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1301	86/9376	1.00559498060526	HRAS/ERBB3/ERBB2/EIF4EBP1/RPS6KB2/PAK1/PIK3CB/MYC/CBLB/SHC1/AKT1/MAPK9	0.0209215075280183
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/1301	130/9376	0.997859634600603	MMP2/COL4A1/COL1A1/COL4A2/COL3A1/PRKCZ/GNAI1/HRAS/GNG5/GNGT2/PIK3CB/SHC1/MAPK13/AKT1/RXFP1/NOS2/CREB5/MAPK9	-0.00986360504902277
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1301	28/9376	1.02953771823872	CA2/ATP6V1G1/ATP6V1C2/ATP6V1B1	0.0628274782108348
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/1301	212/9376	0.985830928313489	ACTB/PGF/PFN1/CALM1/ID1/RAC3/ACTG1/EFNA1/PRKCZ/GNAI1/HRAS/CDH1/FLT1/CTNNB1/RAC2/VASP/FLT4/RAC1/TIAM1/PDGFRB/ITGB1/PDGFRA/PIK3CB/PARD3/FGFR3/SIPA1L1/MAPK13/CDC42/AKT1	-0.0837567483807641
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1301	21/9376	1.02953771823872	DSEL/CHPF/XYLT1	0.0543898318110982
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	34/1301	250/9376	0.980119907763259	HLA-G/LDLR/CAV1/PRKCZ/AP2S1/FOLR1/HRAS/VPS29/ACTR3/RAB11A/ARPC1A/CAV2/ARF4/ARPC2/HSPA8/ARPC5L/PDGFRA/SNF8/ARPC1B/RAB8A/VPS25/ARPC4/ARPC3/CHMP2A/CBLB/PARD3/FGFR3/ASAP3/CLTB/IL2RB/EHD1/ARF3/CDC42/GRK6	-0.127879576144834
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1301	126/9376	0.972341178336567	ACTB/COL1A1/COL3A1/ACTG1/PRKCZ/GNAI1/PPP1CA/MYL12A/PPP1CB/VASP/MYL12B/PPP1CC/ITGB1/PIK3CB/FYN/MAPK13/AKT1	-0.125458791922579
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/1301	178/9376	0.971698520584857	RAC3/NOTUM/RBX1/RUVBL1/TCF7L2/APCDD1/LGR4/WNT7A/CTNNB1/RAC2/CCND3/AXIN2/FRZB/RAC1/CUL1/TLE1/FOSL1/CACYBP/SKP1/MYC/SFRP1/FZD6/BAMBI/MAPK9	-0.153011987984448
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1301	52/9376	0.970141311417253	LDLR/VDAC1/VDAC2/LIPG/LRPAP1/TSPO/VDAC3	-0.08666111842512
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/1301	82/9376	0.96676102810221	HLA-G/CALR/HSPA2/PDIA3/HSPA5/PSME2/HLA-DRB5/TNF/NFYB/HSPA8/PSME3	-0.12134061601625
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1301	22/9376	0.982740549227867	ALDH7A1/ALDH1B1/MAOA	-0.0325306431888793
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/1301	105/9376	0.960901870356136	CLEC7A/IL1B/CALM1/TNF/HRAS/PTGS2/RRAS2/PAK1/PRKCD/PIK3CB/CBLB/MAPK13/AKT1/MAPK9	-0.16171129772269
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/1301	68/9376	0.953836415427047	CCNA2/TCF7L2/JUP/HRAS/EIF4EBP1/RPS6KB2/PIK3CB/MYC/AKT1	-0.153348246456596
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/1301	180/9376	0.960901870356136	HLA-G/CALR/IL1B/ALYREF/SRSF9/PDIA3/ITGA5/CYCS/HLA-DRB5/PPP1CA/TNF/CCL2/PPP1CB/EIF2S1/SRPK1/PPP1CC/SRSF7/EIF4EBP1/BID/SRSF2/PIK3CB/SRSF3/AKT1/IFNGR1	-0.21259144044512
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/1301	173/9376	0.958124697320425	ACTB/FDPS/IL1B/IL1A/KPNA2/VDAC1/ACTG1/CYCS/HLA-DRB5/SLC25A5/TNF/CCL2/RAB11A/EIF2S1/CCND3/RAE1/BID/CDK6/PIK3CB/DNAJC3/CDK4/AKT1/IFNGR1	-0.223135834145093
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1301	38/9376	0.948258424693555	PNP/QPRT/NT5C/ENPP1/BST1	-0.12827958062578
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/1301	122/9376	0.945149380678167	ACTB/DIO2/SLC2A1/ACTG1/PFKP/HRAS/CTNNB1/RCAN1/HDAC2/ATP2A3/HDAC1/PIK3CB/BMP4/MYC/ATP1A1/AKT1	-0.244765229969474
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1301	107/9376	0.942941087732657	LDHA/PKM/PGAM1/SLC2A1/LDHB/CALM1/PFKP/PDHA1/PRMT1/PPP4C/PYGL/AKT1/CREB5/ACACA	-0.238260449642983
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/1301	77/9376	0.935943380217016	HRAS/HDAC2/HDAC1/E2F1/CDK6/PIK3CB/MYC/SHC1/CDK4/AKT1	-0.226539677160742
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1301	63/9376	0.915144638434415	BMP2/TCF7L2/WNT7A/CTNNB1/AXIN2/GLI3/BMP4/FZD6	-0.271242527476294
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1301	32/9376	0.900845503458878	BIRC5/CYCS/BID/MAPK9	-0.225514260030083
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/1301	163/9376	0.928478801110991	CCNE1/BIRC5/CCNA2/CYCS/TNF/HRAS/PCNA/YWHAB/BID/YWHAQ/E2F1/PIK3CB/HSPG2/MYC/VDAC3/CDK2/MAPK13/CCNE2/AKT1/CREB5/MAPK9	-0.369726920408576
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/1301	73/9376	0.888505154096427	HRAS/CDH1/PDGFRB/E2F1/PDGFRA/CDK6/PIK3CB/CDK4/AKT1	-0.383846630118041
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	20/1301	158/9376	0.912248611097598	RPS6/TNF/HRAS/WNT7A/EIF4EBP1/EIF4E2/SEH1L/RPS6KB2/SEC13/SLC7A5/SKP2/LPIN1/PIK3CB/ATP6V1G1/LAMTOR5/ATP6V1C2/ATP6V1B1/RPS6KA3/FZD6/AKT1	-0.44649562894497
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/1301	196/9376	0.919230105570284	HLA-G/RPS27A/CALM1/UBA52/CXCL1/CYCS/TCF7L2/HRAS/CTNNB1/PTGS2/GNG5/RCAN1/BID/RAC1/GNGT2/E2F1/CDK6/PIK3CB/CXCL2/MYC/CDK4/MAPK13/AKT1/MAPK9/IFNGR1	-0.458679395310245
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	18/1301	144/9376	0.900845503458878	LIFR/ID3/ID1/HRAS/DLX5/WNT7A/CTNNB1/ID4/AXIN2/TBX3/PIK3CB/DUSP9/BMP4/MYC/FGFR3/FZD6/MAPK13/AKT1	-0.481281073040981
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	20/1301	160/9376	0.900845503458878	HLA-G/CLDN7/SDC4/CLDN4/PTPRF/HLA-DRB5/CDH5/VCAN/CLDN19/PTPRS/CDH1/CLDN6/ITGA4/ICAM3/SDC1/SPN/CLDN10/ITGB1/NLGN2/CLDN3	-0.507754981635859
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1301	43/9376	0.837995817171049	ACAT2/PLA2G2A/ACAT1/PLA2G10/GOT2	-0.427368829845938
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/1301	83/9376	0.868284822610967	PHF19/CBX3/EZH2/AURKB/TFDP1/RBBP7/HDAC2/HDAC1/SKP1/WDR5	-0.483782238488153
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	12/1301	99/9376	0.873547154869215	IL1B/CALM1/IL1R1/IL1RAP/PPP1CA/PPP1CB/PPP1CC/PRKCD/PIK3CB/MAPK13/CYP2J2/MAPK9	-0.507686301335093
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	19/1301	154/9376	0.889146211206165	TPM1/CALM1/TPM2/TPM4/MYL4/GNAI1/PPP1CA/CACNA2D4/PPP1CB/ATP2A3/PPP1CC/PPP2R1B/ATP2B3/PPP2R3A/MAPK13/CACNB3/ATP1A1/AKT1/CREB5	-0.556738639220512
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1301	44/9376	0.818950457689889	HLA-G/IL1B/IL1A/HLA-DRB5/TNF	-0.483158278752762
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/1301	216/9376	0.900845503458878	LDLR/CCL3L1/IL1B/HSPA2/CALM1/CCL3L3/HSPA5/CXCL1/CYCS/PPARG/HSP90B1/TNF/HRAS/CCL2/EIF2S1/CCL3/BID/RAC1/HSPA8/PIK3CB/CXCL2/VLDLR/MAPK13/CDC42/AKT1/CYP2J2/MAPK9	-0.591758593500477
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/1301	155/9376	0.883409784037093	CCNE1/LDLR/CYP11A1/HSD3B1/GNAI1/TCF7L2/WNT7A/CTNNB1/FH/AXIN2/PBX1/E2F1/CDK6/WDR5/CDK2/CDK4/FZD6/CCNE2/CREB5	-0.587478484424505
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1301	69/9376	0.835566843787945	CALM1/PPP1CA/HDAC2/PPP1CB/PPP1CC/HDAC1/MAOA/CREB5	-0.550252598748133
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/1301	148/9376	0.876498327689719	HEY1/TCF7L2/HRAS/WNT7A/ERBB2/CTNNB1/BRCA1/FLT4/AXIN2/RPS6KB2/E2F1/CDK6/PIK3CB/MYC/SHC1/CDK4/FZD6/AKT1	-0.607859101900895
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/1301	109/9376	0.859522315226819	CCL3L1/IL1B/CCL4L1/CCL3L3/CCL4L2/TNF/CCL4/CCL3/RAC1/PIK3CB/MAPK13/AKT1/MAPK9	-0.592112227190132
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1301	53/9376	0.815860078604267	AP2S1/RAB11A/ATP2B3/PTH1R/CLTB/ATP1A1	-0.539586489616607
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1301	45/9376	0.800751558630114	HLA-G/IL1B/IL1A/HLA-DRB5/TNF	-0.53776200696511
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1301	150/9376	0.864811683320523	CCNE1/TCF7L2/JUP/HRAS/WNT7A/CDH1/ERBB2/CTNNB1/AXIN2/RPS6KB2/E2F1/PIK3CB/MYC/SHC1/CDK2/FZD6/CCNE2/AKT1	-0.669932559865511
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1301	63/9376	0.800751558630114	PTGDS/PLA2G2A/PTGS2/GPX4/PTGES2/PLA2G10/CYP2J2	-0.636903194279706
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/1301	144/9376	0.850798531044496	IL1B/CXCL1/SCD/FASN/TCF7L2/TNF/ADH5/ALDH7A1/CTNNB1/ALDH1B1/LPIN1/CXCL2/MAPK13/IL17RA/AKT1/MAPK9/ACACA	-0.724201580191726
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/1301	105/9376	0.823630174590974	IL1B/CCL4L1/CXCL1/CCL4L2/IL1R1/PLAU/TNF/CCL4/PTGS2/TNFAIP3/PARP1/CXCL2	-0.729472064413549
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1301	30/9376	0.720676402767102	PLA2G2A/PLA2G10/CYP2J2	-0.615047116005286
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/1301	89/9376	0.809748767154047	TUBA1C/TUBB/TUBB6/CDK1/TUBA1B/TUBB4B/GNAI1/HRAS/PDGFRB/PDGFRA	-0.723832003767551
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/1301	73/9376	0.789782359196824	RAN/PPIA/APOBEC3B/NELFE/PSIP1/PIN1/SMARCB1/MAP1B	-0.723722539456671
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1301	48/9376	0.750704586215732	HK2/HK1/PIK3CB/ATP1A1/AKT1	-0.695014171341591
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1301	31/9376	0.697428776871389	ALDH7A1/ALDH1B1/UGDH	-0.67728559047613
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1301	31/9376	0.697428776871389	ALDH7A1/ALDH1B1/ECHS1	-0.67728559047613
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1301	139/9376	0.829555571530477	KRT19/MMP2/KRT18/CALM1/KRT10/KRT23/GNAI1/HSP90B1/HRAS/HSPA8/PRKCD/PIK3CB/SHC1/AKT1/FKBP4/CREB5	-0.812601760265312
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/1301	99/9376	0.800751558630114	MMP2/HRAS/ERBB2/RPS6KB2/E2F1/PIK3CB/SHC1/CDK4/MAPK13/AKT1/MAPK9	-0.799948029174341
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/1301	99/9376	0.800751558630114	RAC3/HRAS/RAC2/EIF4EBP1/RAC1/RPS6KB2/PDGFRB/PDGFRA/PIK3CB/AKT1/MAPK9	-0.799948029174341
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1301	66/9376	0.764353760510563	CYP11A1/HSD3B1/DHRS9/HSD17B7/HSD17B1/DHRS11/CYP19A1	-0.771099926651362
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/1301	66/9376	0.764353760510563	IL1B/IL1A/GATA3/HLA-DRB5/TNF/IL21R/IFNGR1	-0.771099926651362
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1301	12/9376	0.600563668972585	VKORC1L1	-0.555725730501579
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/1301	133/9376	0.812792935451619	CCNB1/CCNB2/BNIP3/IL7R/PLK1/HRAS/PRMT1/SKP2/PIK3CB/PLK2/CDK2/MAPK13/AKT1/PLK4/MAPK9	-0.872759527363688
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1301	76/9376	0.758606739754844	ACTB/CALM1/EZR/ACTG1/GAST/GNAI1/CA2/ATP1A1	-0.848093008852365
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	19/1301	166/9376	0.824870581480418	CALM1/VDAC1/VDAC2/SLC25A5/GNAI1/PPP1CA/MYL9/PPP1CB/ATP2A3/VASP/PPP1CC/ADRA2C/ATP2B3/PPIF/VDAC3/ADRA2B/ATP1A1/AKT1/CREB5	-0.913768863759402
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/1301	134/9376	0.806727316530338	CALD1/MYL6/PLA2G2A/CALM1/PPP1CA/MYH10/MYL9/PPP1CB/PPP1CC/PPP1R14A/PRKCD/MYH9/PLA2G10/ADM/RAMP2	-0.904467392928593
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	39/1301	323/9376	0.870166554424674	CCNE1/IGF2BP1/TPM1/STMN1/EZR/ITGA5/TRIM71/HMGA2/EZH2/FSCN1/SLC7A1/SOX4/EFNA1/DNMT1/PLAU/CDCA5/KIF23/HRAS/RDX/ERBB3/CDC25A/ERBB2/PTGS2/HDAC2/BRCA1/HNRNPK/VIM/HDAC1/PDGFRB/E2F1/PDGFRA/CDK6/PIK3CB/MYC/CD44/CDC25C/FGFR3/SHC1/CCNE2	-0.953113464263129
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	36/1301	300/9376	0.864811683320523	PGF/IL1B/IL1A/STMN1/FLNA/RAC3/EFNA1/IL1R1/IL1RAP/TNF/HRAS/CACNA2D4/ERBB3/FLT1/ERBB2/PTPN7/RAC2/PPP5C/FLT4/RRAS2/RAC1/DUSP4/PAK1/HSPA8/PDGFRB/PDGFRA/DUSP5/DUSP9/MYC/FGFR3/RPS6KA3/MAPK13/CACNB3/CDC42/AKT1/MAPK9	-0.955224746832405
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	21/1301	183/9376	0.827005708093396	RAN/NHP2/FBL/GNL3/NOP56/DKC1/NOP58/POP7/NOP10/WDR43/EMG1/EIF6/GTPBP4/IMP4/RPP30/RIOK1/UTP14A/POP5/TCOF1/RBM28/MPHOSPH10	-0.948596917879727
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/1301	119/9376	0.787293549241372	IL1B/CXCL1/TNF/CCL2/PTGS2/TNFAIP3/PIK3CB/CXCL2/MAPK13/CCL20/AKT1/CREB5/MAPK9	-0.937285785590902
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	21/1301	184/9376	0.822511111853758	CFL1/RAC3/EFNA1/PRKCZ/GNAI1/HRAS/MYL12A/MYL9/ILK/RAC2/SEMA4C/MYL12B/RAC1/PAK1/ITGB1/PIK3CB/FYN/PARD3/ROBO1/SEMA4B/CDC42	-0.975951179963876
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/1301	120/9376	0.780732769664361	YWHAE/CALM1/MATK/HRAS/RAC1/PRKCD/PIK3CB/SHC1/RPS6KA3/MAPK13/CDC42/AKT1/MAPK9	-0.97029926386994
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1301	70/9376	0.720676402767102	LEP/SLC2A1/TNF/ACSL4/AKT1/ACSL6/MAPK9	-0.941516950718056
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/1301	44/9376	0.655160366151911	DYNLL1/RAB11A/DYNC1LI1/CREB5	-0.920257084386291
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1301	71/9376	0.710526030897143	CGA/HRAS/PIK3CB/SHC1/MAPK13/AKT1/MAPK9	-0.982728435299112
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1301	122/9376	0.767933871801011	TNF/HRAS/PPP2R1B/PAK1/PIK3CB/FYN/CBLB/PPP2R3A/CDK4/MAPK13/CDC42/AKT1/MAPK9	-1.03557115560483
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1301	36/9376	0.600563668972585	DCXR/UGP2/UGDH	-0.96378108165891
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1301	26/9376	0.554366463667002	SLC5A6/SLC19A1	-0.913296421381094
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1301	73/9376	0.691059564297221	GSTP1/MGST3/MGST1/ADH5/MAOA/GSTA4/GSTO2	-1.0635984487953
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/1301	73/9376	0.691059564297221	HRAS/ERBB2/E2F1/CDK6/PIK3CB/CDK4/AKT1	-1.0635984487953
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/1301	133/9376	0.758606739754844	CALM1/GNAI1/PPP1CA/GNG5/PPP1CB/PPP1CC/PPP2R1B/GNGT2/MAOA/PPP2R3A/MAPK13/AKT1/CREB5/MAPK9	-1.12537562740265
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/1301	142/9376	0.761277890246939	IL1B/IL1A/PPARG/IL1R1/FHL2/TNF/ATP2A3/RAC1/FOSL1/PIK3CB/FYN/MAPK13/AKT1/MAPK9/IFNGR1	-1.15052193238701
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/1301	38/9376	0.568955054816133	PIK3CB/SFN/ATP1A1	-1.06866218261743
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1301	38/9376	0.568955054816133	IL7R/ADA/UNG	-1.06866218261743
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1301	102/9376	0.706545492908924	PLA2G2A/RAB11A/ATP2A3/RAC1/CA2/ATP2B3/RAB8A/PLA2G10/ATP1A1/BST1	-1.19608032144872
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/1301	67/9376	0.645381853224271	CALM1/PPP1CA/HRAS/PPP1CB/PPP1CC/RPS6KA3	-1.16922976610802
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/1301	154/9376	0.748754704173613	ACTB/MYL6/CALM1/CAMK1/ACTG1/GNAI1/PPP1CA/HRAS/CACNA2D4/MYL9/PTGS2/RCAN1/PPP1CB/PPP1CC/EEF2/CACNB3	-1.26182393611356
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1301	17/9376	0.423927295745354	SEPHS1	-0.954201414022775
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1301	39/9376	0.554366463667002	HLA-G/HLA-DRB5/TNF	-1.11933352511453
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/1301	59/9376	0.610742714209409	CGA/GNAI1/PTGS2/PIK3CB/AKT1	-1.20386483575666
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/1301	157/9376	0.734447289444181	CALR/SLC2A1/UQCRFS1/PPARG/ODC1/BSG/PTGS2/SLC16A1/ATP2A3/ARG2/RAC1/PBX1/DUSP4/DUSP5/ATP11C/MAPK13	-1.34682657903957
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1301	79/9376	0.638574027768319	GSTP1/MGST3/MGST1/ADH5/CYP2S1/GSTA4/GSTO2	-1.29483523557424
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1301	70/9376	0.61772263094323	GSTP1/MGST3/MGST1/PTGS2/GSTA4/GSTO2	-1.28854356169111
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/1301	133/9376	0.70442054405807	HLA-G/RAC3/CD48/TNF/HRAS/RAC2/BID/RAC1/PAK1/PIK3CB/FYN/SHC1/IFNGR1	-1.3779917274416
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1301	226/9376	0.765320073734976	CGA/CALM1/RAC3/GNAI1/PPP1CA/SUCNR1/MYL9/PPP1CB/RAC2/ATP2A3/PPP1CC/RRAS2/RAC1/PAK1/TIAM1/ATP2B3/GLI3/PIK3CB/FFAR2/ATP1A1/AKT1/PDE4D/CREB5/MAPK9	-1.43341728323237
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1301	168/9376	0.729255883752425	HMGB1/IL1B/PPIA/IL1A/VDAC1/VDAC2/SLC25A5/TNF/TNFAIP3/BID/CHMP2A/PARP1/VDAC3/GLUD1/PYGL/MAPK9/IFNGR1	-1.42129436415872
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/1301	90/9376	0.640601246904091	PPARG/HRAS/EIF4EBP1/EIF4E2/RPS6KB2/PIK3CB/AKT1/CREB5	-1.37510702913734
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/1301	109/9376	0.661171011712938	IL1B/GATA3/IL1R1/IL1RAP/HLA-DRB5/IL21R/IL2RB/MAPK13/MAPK9/IFNGR1	-1.42816125717879
Human Diseases	Immune disease	hsa05310	Asthma	2/1301	32/9376	0.450422751729439	HLA-DRB5/TNF	-1.2499433792365
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/1301	238/9376	0.757013028116704	PGF/PLA2G2A/CALM1/RALBP1/RAC3/EFNA1/HRAS/FLT1/GNG5/RAC2/FLT4/RRAS2/RAC1/GNGT2/PAK1/TIAM1/PDGFRB/PDGFRA/PIK3CB/PLA2G10/FGFR3/SHC1/CDC42/AKT1/MAPK9	-1.52404893400543
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/1301	181/9376	0.716694765182754	CLEC7A/IL1B/IL1A/CALM1/CYCS/HLA-DRB5/TNF/NFYB/MRC1/BID/CEBPG/CORO1A/MAPK13/AKT1/NOS2/HSPA9/MAPK9/IFNGR1	-1.54479566111821
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/1301	93/9376	0.619936690552346	CGA/MMP2/CALM1/HRAS/PRKCD/MAPK13/CDC42/MAPK9	-1.4784487203993
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/1301	65/9376	0.554366463667002	LDLR/CYP11A1/HSD3B1/PBX1/CREB5	-1.44706954138539
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/1301	65/9376	0.554366463667002	CGA/HRAS/KISS1R/PIK3CB/AKT1	-1.44706954138539
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1301	217/9376	0.730639671008122	BIRC5/KPNA2/MGST3/MGST1/GNAI1/HSP90B1/HRAS/KPNB1/CDC6/CDC25A/KLF5/CCND3/EIF4EBP1/RPS6KB2/E2F1/PIK3CB/MYC/GSTA4/GSTO2/RPS6KA3/AKT1/CREB5	-1.61135967939526
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/1301	140/9376	0.669199516855166	RPS6/CALM1/MYL4/GNAI1/HRAS/CDH1/GNG5/RRAS2/GNGT2/RPS6KB2/TFAM/AKT1/NOS2	-1.58285528954566
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1301	23/9376	0.313337566420479	MME	-1.32338058878374
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1301	36/9376	0.400375779315057	GALNT2/ST6GALNAC1	-1.44680499771803
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/1301	88/9376	0.573265320382922	TFPI/PROCR/C1R/PLAU/SERPINB2/CD55/THBD	-1.6143258159488
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/1301	98/9376	0.588307267564981	LDLR/CYP11A1/CALM1/CAMK1/HSD3B1/ATP2B3/ATP1A1/CREB5	-1.64441744443244
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1301	24/9376	0.300281834486293	XYLT1	-1.37762032502602
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1301	49/9376	0.441230450673736	GNAI1/MAOA/CREB5	-1.57402926765138
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/1301	90/9376	0.56052609104108	HRAS/RPS6KB2/PIK3CB/MAPK13/BATF3/AKT1/IFNGR1	-1.68148513628984
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/1301	91/9376	0.554366463667002	RAC3/HRAS/RAC2/IFITM1/RAC1/PIK3CB/AKT1	-1.71459135432629
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1301	72/9376	0.500469724143821	ISG15/TNF/PIN1/MAPK13/MAPK9	-1.70783627429947
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1301	51/9376	0.423927295745354	PLA2G2A/PAFAH1B3/PLA2G10	-1.65573559961741
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/1301	62/9376	0.464952517914259	HEY1/HDAC2/HDAC1/TLE1	-1.69657504069991
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	17/1301	187/9376	0.655160366151911	IL1B/YWHAE/TXN/CXCL1/VDAC1/VDAC2/TNF/TXN2/CCL2/TNFAIP3/TRIP6/PRKCD/CXCL2/SUGT1/VDAC3/MAPK13/MAPK9	-1.9118634636676
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1301	28/9376	0.257384429559679	ST3GAL4	-1.5795622124159
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/1301	65/9376	0.443493170933601	ALDH7A1/ALDH1B1/LIPG/LPIN1	-1.80709936810768
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1301	54/9376	0.400375779315057	CGA/HLA-G/HLA-DRB5	-1.77367693563811
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1301	29/9376	0.248509104402449	CALM1	-1.62682044598731
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/1301	298/9376	0.701329385243153	LEP/CCL3L1/IL1B/CCL4L1/IL1RN/IL1A/LIFR/CCL3L3/BMP2/IL7R/CXCL1/CXCL14/CCL4L2/IL1R1/IL1RAP/CCR7/TNF/CCL2/CCL4/CCL3/TNFSF15/IL21R/BMP4/CXCL2/OSMR/IL2RB/CCL20/IL17RA/IFNGR1	-2.10309339618464
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1301	68/9376	0.423927295745354	ADH5/CYP2S1/DHRS9/ALDH1A3	-1.9136239060759
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/1301	79/9376	0.456124305548799	AP2S1/ATP6V1G1/ATP6V1C2/ATP6V1B1/CLTB	-1.94847483870473
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1301	90/9376	0.480450935178068	LDLR/SLC2A1/HMGCR/ABCG2/CA2/ATP1A1	-1.98786324344234
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	17/1301	195/9376	0.628281992155935	ACTB/HMGB1/CLEC7A/VDAC1/ACTG1/VDAC2/SLC25A5/HDAC2/RAC2/RAC1/HDAC1/HAT1/PIK3CB/PPIF/VDAC3/MAPK13/AKT1	-2.105420920213
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/1301	45/9376	0.320300623452045	ABCA7/ABCG2	-1.83447608599765
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1301	168/9376	0.600563668972585	LEP/LIFR/IL7R/HRAS/CCND3/IL21R/PDGFRB/PDGFRA/PIK3CB/MYC/OSMR/IL2RB/AKT1/IFNGR1	-2.0968751380376
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/1301	101/9376	0.499478694987101	CALM1/GNAI1/TCF7L2/HRAS/WNT7A/CTNNB1/FZD6	-2.02992184363163
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/1301	122/9376	0.531646526631469	IGFBP3/GNAI1/HRAS/PIK3CB/SHC1/MAPK13/AKT1/CREB5/MAPK9	-2.08997905645196
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1301	93/9376	0.464952517914259	GATA3/HLA-DRB5/IL2RB/MAPK13/MAPK9/IFNGR1	-2.08133814966814
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/1301	60/9376	0.360338201383551	GNAI1/HRAS/PPP2R1B	-1.99509840367429
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1301	115/9376	0.501340106272767	GNAI1/HRAS/GNG5/GNGT2/PIK3CB/FYN/AKT1/CREB5	-2.15962048942912
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/1301	115/9376	0.501340106272767	GCM1/NACA/GATA3/GNAI1/MMP15/PTH1R/PDE4D/CREB5	-2.15962048942912
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/1301	49/9376	0.294153633782491	GALNT2/GXYLT1	-1.98833819815584
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1301	50/9376	0.288270561106841	HLA-DRB5/ITGA4	-2.0253740778823
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/1301	169/9376	0.554366463667002	RPS27A/HMGB1/UBA52/BNIP3/HRAS/EIF2S1/RRAS2/RPS6KB2/PRKCD/RAB8A/PIK3CB/AKT1/MAPK9	-2.34647087557488
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1301	99/9376	0.436773577434607	KRT19/KRT18/KRT10/C1R/KRT23/HLA-DRB5	-2.26125666837058
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/1301	78/9376	0.369577642444668	TPI1/PI4K2B/IMPA2/PIK3CB	-2.24407391809952
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1301	191/9376	0.565976232539609	CALM1/GNAI1/PPP1CA/HRAS/GNG5/HDAC2/PPP1CB/PPP1CC/GNGT2/HDAC1/HAT1/MAOA/SHC1/PKIA/CREB5	-2.43244840260832
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/1301	201/9376	0.573672758421574	CCNA2/HMGA2/IGFBP3/PPARG/PLAU/JUP/MYCN/FLT1/HDAC2/NFKBIZ/SPINT1/PBX1/HDAC1/ETV4/MYC/IL2RB	-2.45239881403136
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/1301	91/9376	0.39597604547643	GNAI1/GNG5/GNGT2/PDE4D/GRK6	-2.32400429005909
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/1301	55/9376	0.262064146460764	CERS5/B4GALT6	-2.2030366558296
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/1301	104/9376	0.415774847750251	PLA2G2A/PCYT2/PHOSPHO1/PEMT/LPIN1/PLA2G10	-2.40471288023209
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/1301	115/9376	0.438672592988671	GNAI1/HRAS/PTGS2/GNG5/GNGT2/MAOA/CYP2J2	-2.43102399994271
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/1301	56/9376	0.257384429559679	CUL1/GLI3	-2.23719133802516
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/1301	143/9376	0.453572561182092	SNRPB/SNRPD1/ACTN1/SNRPD3/C1R/HLA-DRB5/ACTN4/TNF/SSB	-2.64290846054316
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/1301	89/9376	0.323899506861619	GNAI1/SLC38A1/GNG5/GNGT2	-2.57229962390225
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/1301	93/9376	0.309968345276173	CALM1/ATP2B3/ATP1A1/BST1	-2.68422757893698
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/1301	69/9376	0.208891710946986	CALM1/GNAI1	-2.64733343305305
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/1301	97/9376	0.29718614547097	CALM1/GNAI1/GNG5/GNGT2	-2.79272784297888
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/1301	98/9376	0.294153633782491	CALM1/PI4K2B/IMPA2/PIK3CB	-2.81935041901797
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/1301	86/9376	0.251398745151315	SLC2A1/ATP1A1/CREB5	-2.79927097049801
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/1301	149/9376	0.386940350478981	HRAS/RRAS2/PDGFRB/PDGFRA/PIK3CB/FYN/SHC1/AKT1	-3.02774034195593
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/1301	254/9376	0.510715561016057	CALM1/CAMK1/VDAC1/VDAC2/SLC25A5/ERBB3/ASPH/FLT1/ERBB2/ATP2A3/FLT4/PDGFRB/PDGFRA/ATP2B3/PPIF/FGFR3/VDAC3/NOS2	-3.17311819360137
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/1301	116/9376	0.248509104402449	GNAI1/SLC38A1/GNG5/GNGT2	-3.2688895416544
NA	NA	hsa04081	Hormone signaling	12/1301	219/9376	0.394891179598412	CGA/LEP/DIO2/GAST/GNAI1/GNG5/GNGT2/ADRA2C/PIK3CB/PTH1R/ADRA2B/RAMP2	-3.63690498202069
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	13/1301	250/9376	0.374751729438893	LAPTM4B/AP2S1/VPS29/CTSV/CTSE/AP1M2/ATP6V1G1/LAMTOR5/ATP6V1C2/ATP6V1B1/CLTB/BLOC1S4/AP1S1	-4.02193726631082
NA	NA	hsa04082	Neuroactive ligand signaling	6/1301	199/9376	0.217289367668473	OGFRL1/GNAI1/GNG5/GNGT2/ADRA2C/ADRA2B	-4.47950913566241
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/1301	370/9376	0.311643849845233	CGA/LEP/TMEM97/OGFRL1/LTB4R/TSPO/KISS1R/ADRA2C/GAL/VGF/NPW/PTH1R/ADRA2B/RXFP1/GPR35/ADM	-5.42251932810038
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/1301	449/9376	0.0160506993934767	CALM1	-8.57622458738657