category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	101/678	222/9376	6.29153046852162	RPS27/RPL37/RPL13/RPL36/RPL29/RPS12/RPS18/RPL24/RPL18/RPL34/RPS3A/RPL39/RPL18A/RPL11/RPS15/RPS29/RPL32/RPLP0/RPL23A/RPS6/RPS4X/RPS28/RPL30/RPL6/RPL14/RPL37A/RPL38/RPL31/RPS7/RPLP2/RPS16/RPS8/RPS14/RPS2/RPL22/RPS24/RPS19/RPL35A/RPS13/RPS23/RPS11/RPL28/RPL7A/RPL21/RPL8/RPLP1/RPL27A/RPS20/RPS25/RPL10/RPL26/RPL9/RPL3/RPL5/RPS5/RPS27A/RPL12/RPS3/RPL10A/RPS15A/RPL35/RPL13A/RPL23/RPL19/RPS9/RPL41/RPS26/MRPS2/RPSA/MRPL4/UBA52/RPL15/MRPL36/MRPL15/RPL27/RPL7/MRPL22/MRPS5/MRPS14/MRPS26/MRPS18A/MRPL17/MRPL42/MRPL12/MRPS34/MRPL37/MRPS16/FAU/MRPS22/MRPL55/RPL26L1/MRPL11/MRPL18/MRPL28/MRPL1/MRPS6/RPL4/MRPS18C/MRPL24/MRPS33/MRPL14	22.2763030661486
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	83/678	238/9376	4.8226865967626	RPS27/RPL37/RPL13/RPL36/RPL29/RPS12/RPS18/RPL24/RPL18/RPL34/RPS3A/RPL39/RPL18A/RPL11/RPS15/RPS29/RPL32/RPLP0/RPL23A/RPS6/RPS4X/RPS28/RPL30/RPL6/RPL14/RPL37A/RPL38/RPL31/RPS7/RPLP2/RPS16/RPS8/RPS14/RPS2/RPL22/RPS24/RPS19/RPL35A/RPS13/RPS23/RPS11/RPL28/RPL7A/RPL21/RPL8/RPLP1/RPL27A/RPS20/RPS25/RPL10/RPL26/RPL9/RPL3/RPL5/RPS5/RPS27A/RPL12/RPS3/RPL10A/RPS15A/RPL35/RPL13A/RPL23/RPL19/RPS9/RPL41/CCL2/RPS26/RPSA/UBA52/RPL15/TLR4/RPL27/RPL7/IFNAR2/TLR2/FAU/RELA/RPL26L1/ISG15/OAS1/RPL4/MAPK9	16.6771708892251
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	32/678	158/9376	2.80079160598932	CDKN1C/CCNE1/CCNB1/CDK1/CDC20/AURKB/CCNA2/E2F4/ANAPC5/NDC80/ANAPC15/ANAPC13/PRKDC/PLK1/CCNB2/STAG2/TP53/SMC1A/PPP2R1A/SMC3/CDC25C/HDAC2/RAD21/MCM5/PDS5A/WEE1/SKP2/MAD2L1/CDC16/CDC6/HDAC1/CDCA5	6.37330104012235
Genetic Information Processing	Transcription	hsa03040	Spliceosome	36/678	243/9376	2.04872719326997	HNRNPA1/SNRPD2/SLU7/SYF2/ACIN1/EIF4A3/PRPF8/SNRNP40/CCDC12/SNRNP200/PPIE/SNRNP27/RBM22/TRA2A/SF3A3/DDX23/SF3B4/SRSF6/TCERG1/PRPF31/SART1/PPIH/RBM8A/PUF60/SF1/SRSF1/SNW1/PRPF4/RP9/WBP11/U2AF2/PRPF38A/THOC7/CWC15/DDX46/PRPF19	4.62433960709398
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	19/678	103/9376	2.55096371395023	PPP1CC/RNMT/ACIN1/WDR82/EIF4A3/UPF3B/PNN/UPF1/WDR33/PPP2R1A/RBM8A/RNPS1/PCF11/UPF2/NXT1/CSTF3/GLE1/CSTF1/HBS1L	4.41876497747759
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	19/678	108/9376	2.43286354200808	NUP62/ACIN1/EIF4A3/UPF3B/PNN/TPR/XPO1/KPNA6/UPF1/IPO8/RAE1/RBM8A/RNPS1/UPF2/NXT1/THOC7/GLE1/NUP93/RANGAP1	4.18133035443938
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	22/678	142/9376	2.14250695915908	UBE2C/CDC20/RPS27A/UBA52/CUL5/ANAPC5/ANAPC15/ANAPC13/UBA6/UBA7/UBE2Z/KEAP1/UBE2J2/DDB1/SKP2/UBE3B/CDC16/UBE2Q2/UBA2/HUWE1/CDC34/PRPF19	3.83000088787331
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/678	157/9376	1.93780884204197	CCNE1/HLA-G/CCNB1/CDK1/CCNA2/CAPN1/CALM1/PPP1CC/PPID/E2F4/TRPM7/CAPN2/RAF1/CCNB2/NBN/TP53/MAP2K2/PPP3CA/RELA/PTEN/HRAS/SQSTM1	3.30836201109552
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/678	110/9376	2.1371949584339	RPS6/GAPDH/TIMP1/EGLN2/SLC2A1/TLR4/PDHB/PDHA1/MAP2K2/MKNK2/RELA/RPS6KB2/HK1/HMOX1/HK2/RPS6KB1/NOS2	3.349468545737
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/678	116/9376	2.02665039161835	GAPDH/PHGDH/GOT1/PDHB/GLDC/GPI/PDHA1/G6PD/ACO1/PGP/GCSH/ESD/IDH1/PSAT1/HK1/SUCLA2/HK2	3.10625326017545
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	17/678	117/9376	2.00932859339939	BAZ1B/SMARCE1/UCHL5/SMARCA4/POLE3/SMARCD1/YEATS4/HDAC2/BRD9/DMAP1/SMARCA5/PHF10/INO80C/MCRS1/HDAC1/GATAD2A/SMARCB1	3.06714458376876
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/678	71/9376	2.33728031908264	SLC2A1/RAF1/PDHB/TP53/PDHA1/MAP2K2/G6PD/IDH1/PTEN/HK1/HRAS/HK2	3.15779710452177
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	19/678	138/9376	1.90398016331068	CCNE1/CCNB1/CDK1/CDC20/CALM1/PPP1CC/ANAPC5/SLK/ANAPC15/ANAPC13/PLK1/CCNB2/SMC1A/PPP2R1A/SMC3/PPP3CA/CDC25C/MAD2L1/CDC16	2.98675946236073
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	22/678	170/9376	1.78962346000347	SMARCE1/IGF2/GSTP1/WNT7A/SMARCA4/RAF1/SMARCD1/SHC1/TP53/KEAP1/MAP2K2/GSTA4/LRP6/PTEN/GSTM4/RPS6KB2/BAD/PHF10/HMOX1/HRAS/RPS6KB1/SMARCB1	2.90067987477575
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/678	33/9376	2.93340484490927	AADAT/GOT1/PDHB/PDHA1/ACO1/BCAT2/IDH1	3.10618545351331
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/678	105/9376	1.9755583649389	RPS27A/UBA52/FUNDC1/RAB5A/MTX2/TP53/EIF2S1/RELA/MFN1/MAPK9/OPTN/HRAS/ARIH1/HUWE1/SQSTM1	2.80656690430668
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/678	77/9376	2.15515457993334	CRK/RAF1/SHC1/TP53/MAP2K2/HDAC2/RELA/CTBP2/BAD/RUNX1/HRAS/HDAC1	2.84156847870799
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/678	169/9376	1.71838508666283	RPS27A/HMGB1/GORASP2/UBA52/RAF1/RB1CC1/STK11/RRAGA/EIF2S1/MAP2K2/WIPI1/PTEN/RPS6KB2/BAD/MAPK9/OPTN/HRAS/VPS39/EPG5/SQSTM1/RPS6KB1	2.63106981519776
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	26/678	224/9376	1.60514117151285	CCNE1/HLA-G/CDC20/CCNA2/MSX2/SLC2A1/ANAPC5/ANAPC15/ANAPC13/XPO1/CCNB2/TP53/RANBP1/MAP2K2/PPP3CA/NFKB2/RELA/PTEN/MAD2L1/GPS2/DLG1/CDC16/EGR1/ATF2/MAPK9/HRAS	2.55925457666763
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/678	214/9376	1.6155267003005	HLA-G/CCNB1/CDK1/CALM1/GNAI1/AP1M2/RAC3/CRK/CUL5/TLR4/RAF1/TLR2/CCNB2/MAP2K2/PPP3CA/CDC25C/RELA/DDB1/WEE1/RPS6KB2/BAD/GNAQ/MAPK9/HRAS/RPS6KB1	2.54301793384443
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/678	205/9376	1.61899417224261	CCNE1/HLA-G/CDK1/CDC20/CCNA2/GTF2B/TP53/GTF2A2/RBPJ/RANBP1/NFKB2/HDAC2/SND1/RELA/DDB1/SNW1/SKP2/HDAC5/DLG1/BAD/GTF2H3/ATF2/HRAS/HDAC1	2.50176163060351
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/678	142/9376	1.75296023931198	CAV1/CALM1/CCL2/GSTP1/RAC3/TP53/KEAP1/RELA/GSTA4/GSTM4/CAV2/BMPR2/HMOX1/MAPK9/MMP2/SQSTM1/SDC4/CDH5	2.52413200810677
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/678	125/9376	1.77010029498525	GNAI1/RAC3/RAF1/NSMAF/TP53/PPP2R1A/SPTSSA/MAP2K2/S1PR4/RELA/PTEN/GNAQ/ROCK2/MAPK9/HRAS/CERS5	2.41990735332845
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/678	138/9376	1.70356119875166	RPS6/CALM1/PPP1CC/CRK/RAPGEF1/RAF1/SHC1/FLOT2/MAP2K2/MKNK2/RPS6KB2/BAD/HK1/MAPK9/HRAS/HK2/RPS6KB1	2.32457320747555
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/678	59/9376	2.10949452527374	RRM2/PRDX6/GSTP1/GPX8/G6PD/IDH1/GSTA4/GSTM4/HPGDS	2.38673336945164
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/678	110/9376	1.76004290694556	CCNB1/CDK1/CCNA2/GNAI1/ANAPC5/ANAPC15/ANAPC13/RAF1/PLK1/CCNB2/CDC25C/MAD2L1/CDC16/MAPK9	2.23861334535863
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/678	122/9376	1.70027564195561	SLC2A1/DIO2/RAF1/RXRA/MED1/TP53/MAP2K2/HDAC2/MED4/MED16/BAD/MED12L/HRAS/HDAC1/NCOA3	2.17357670802001
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/678	63/9376	1.9755583649389	POLE3/RAD23B/POLR2C/CETN2/POLR2K/DDB1/XPA/GTF2H3/GTF2H5	2.16904975306113
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/678	73/9376	1.89437103487291	SUPT5H/BICD2/PIN1/CHMP4B/XPO1/HGS/TSG101/ELL/VPS4A/SMARCB1	2.14169897459593
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/678	75/9376	1.84385447394297	TOP2A/BIRC5/GSTP1/TOP2B/TP53/GSTA4/GSTM4/BAD/XPA/MSH3	2.04844425689801
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/678	19/9376	2.91134916938364	PDHB/GLDC/PDHA1/GCSH	2.32830194718286
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/678	46/9376	2.10439912786969	PSMD6/PSMB10/PSMD3/PSMD12/PSME3/PSMD11/PSMD13	2.0963072312694
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/678	37/9376	2.24252571155226	GALK1/GPI/HK1/UGDH/HK2/UAP1	2.1142037662441
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/678	37/9376	2.24252571155226	RXRA/TPR/TFG/TP53/MAP2K2/HRAS	2.1142037662441
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/678	87/9376	1.74848269080799	BIRC5/RAC3/RAF1/TP53/MAP2K2/RPS6KB2/BAD/MAPK9/HRAS/MSH3/RPS6KB1	1.95815781288307
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/678	12/9376	3.45722713864307	COQ4/COQ6/COQ5	2.37791325194519
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/678	99/9376	1.67623133994815	RAF1/SHC1/MED1/TP53/MAP2K2/RPS6KB2/BAD/MAPK9/HRAS/MMP2/NCOA3/RPS6KB1	1.88842567625252
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/678	38/9376	2.18351187703773	GALK1/GPI/HK1/UGDH/HK2/UAP1	2.04093074294676
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/678	68/9376	1.83029672045809	CCNA2/RAF1/MAP2K2/RELA/RPS6KB2/BAD/RUNX1/HRAS/RPS6KB1	1.91844951520859
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/678	90/9376	1.69019993444772	TLR4/RAF1/BATF/TLR2/MAP2K2/PPP3CA/RELA/PTEN/RPS6KB2/HRAS/RPS6KB1	1.8368454305932
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/678	21/9376	2.63407781991853	AASDHPPT/PANK2/PANK3/BCAT2	2.09291345533382
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/678	30/9376	2.30481809242871	PDHB/PDHA1/ACO1/IDH1/SUCLA2	1.99842793763958
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	21/678	205/9376	1.41661990071228	CCNE1/HLA-G/CCNA2/PSMD6/IFNAR2/PSMD3/TLR2/PSMD12/TP53/RBPJ/NFKB2/HDAC2/RELA/SNW1/ISG15/SKP2/OAS1/MAPK9/PSMD11/PSMD13/HDAC1	1.68383440246562
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/678	50/9376	1.93604719764012	HBA1/HBA2/GYPB/GYPA/CCL2/TLR4/TLR2	1.8527884191051
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/678	93/9376	1.63567735591715	CCNE1/LAMB1/LAMA4/COL4A1/RXRA/TP53/RELA/SKP2/PTEN/CKS1B/NOS2	1.71998565092844
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/678	85/9376	1.62693041818497	RRM2/TYMS/GMPR2/NUDT16/NT5C3A/AK5/NME6/NT5C/HPRT1/NTPCR	1.62101994440848
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/678	75/9376	1.65946902654867	RRM2/CCNE1/CCNB1/CDK1/PERP/GTSE1/CCNB2/TP53/PTEN	1.60085130997012
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/678	44/9376	1.88576025744167	GTF2B/GTF2F1/TAF3/GTF2A2/GTF2H3/GTF2H5	1.64416707469073
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/678	203/9376	1.36245404478545	CAV1/PGF/LAMB1/PPP1CC/LAMA4/COL4A1/RAC3/CRK/RAPGEF1/CAPN2/RAF1/SHC1/PARVA/PTEN/CAV2/VAV3/BAD/ROCK2/MAPK9/HRAS	1.45759226938203
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	16/678	158/9376	1.40039580299466	RPS6/WNT7A/CLIP1/RAF1/ATP6V1B1/STK11/RRAGA/MAP2K2/ATP6V1E1/SKP2/LRP6/PTEN/RPS6KB2/FNIP2/HRAS/RPS6KB1	1.41706734926974
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/678	56/9376	1.72861356932153	TLR4/TLR2/SAR1A/NFKB2/RELA/NAIP/HBS1L	1.5267716807137
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/678	170/9376	1.38289085545723	CLDN10/JAM3/CLDN6/CLDN3/MYH10/RAPGEF2/STK11/PPP2R1A/DLG3/MPDZ/DLG1/WHAMM/PARD3/ROCK2/RAP2C/RUNX1/MAPK9	1.4065486335165
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/678	78/9376	1.59564329475834	DHX36/CNOT2/NUDT16/LSM1/CNOT1/PATL1/EXOSC1/DCP2/EXOSC9	1.47478791824621
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	42/678	480/9376	1.21002949852507	COX8C/RPS27A/CAPN1/CALM1/WNT7A/PPID/UBA52/PSMD6/CAPN2/PSMD3/RAF1/RAB5A/RB1CC1/DCTN3/TUBB6/APP/UBA7/GPX8/DCTN1/DCTN4/CHMP2B/PSMD12/EIF2S1/MAP2K2/PPP3CA/NDUFA5/NDUFS4/RELA/UBE2J2/WIPI1/LRP6/MFN1/BAD/GNAQ/MAPK9/OPTN/HRAS/PSMD11/PSMD13/SQSTM1/NOS2/NDUFC1	1.31884668019859
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	33/678	368/9376	1.24009234320893	COX8C/HNRNPA1/NUP62/PSMD6/PSMD3/RAB5A/RB1CC1/DCTN3/TUBB6/GPX8/DCTN1/DCTN4/TPR/CHMP2B/PSMD12/RAE1/TP53/EIF2S1/PPP3CA/NDUFA5/NDUFS4/HNRNPA2B1/WIPI1/NXT1/BAD/OPTN/PSMD11/PSMD13/GLE1/NUP93/SQSTM1/NOS2/NDUFC1	1.31183379313247
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/678	91/9376	1.51966028072223	PIK3AP1/RAC3/RAF1/LILRB1/MAP2K2/PPP3CA/RELA/VAV3/HRAS/INPP5D	1.39072111719675
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/678	80/9376	1.55575221238938	RPS6/RAF1/SHC1/MAP2K2/PTEN/RPS6KB2/BAD/HRAS/RPS6KB1	1.39369877942636
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	23/678	248/9376	1.28251974498049	RPS3/GAPDH/TLR4/NCKAP1/RAF1/RAB5A/DCTN3/TUBB6/DNM2/DCTN1/DCTN4/TLR2/GSDMD/TNFSF10/MAP2K2/RELA/PIK3C2A/NAIP/ROCK2/MAPK9/HRAS/CYTH2/VPS39	1.25886052054612
NA	NA	hsa03272	Virion - Hepatitis viruses	6/678	48/9376	1.72861356932153	CLDN10/CLDN6/CLDN3/CHMP4B/TSG101/VPS4A	1.4129096408535
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/678	70/9376	1.58044669195112	EGLN2/SLC2A1/CRK/RAPGEF1/RAF1/MAP2K2/BAD/HRAS	1.36088246998412
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/678	59/9376	1.6407179641018	CTNNA1/RAF1/TP53/MAP2K2/PTEN/BAD/HRAS	1.37830598573849
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/678	200/9376	1.31374631268437	CLDN10/RPS3/GAPDH/CLDN6/CLDN3/MYH10/TLR4/NCKAP1/TUBB6/TNFSF10/SEC24A/MYO1B/RELA/NAIP/SEC24C/ROCK2/MAPK9/CYTH2/MYO1C	1.25215389652948
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	23/678	250/9376	1.27225958702065	HLA-G/CAV1/ZFYVE16/VTA1/SNX4/VPS37A/EPN1/RAB5A/DNM2/CHMP4B/SNX12/CHMP2B/RAB35/HGS/ARFGEF2/TSG101/VPS4A/CAV2/PARD3/AP2A1/HRAS/CYTH2/SH3GLB2	1.21815832343824
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/678	83/9376	1.49952020471266	PMVK/PEX2/ACOT8/PHYH/ABCD3/IDH1/ECI2/ACSL4/NOS2	1.27615939022882
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/678	29/9376	1.90743566269962	TEAD4/YAP1/SAV1/TEAD3	1.36637373217901
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/678	156/9376	1.32970274563195	CLDN10/CLDN6/CLDN3/IFNAR2/RAF1/RXRA/TP53/EIF2S1/PPP2R1A/MAP2K2/RELA/PSME3/BAD/OAS1/HRAS	1.15933830644864
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/678	62/9376	1.56132838519364	RBPJ/DTX3L/HDAC2/SNW1/CTBP2/TLE1/HDAC1	1.23804239162499
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/678	193/9376	1.28974276674767	CCL13/GNAI1/CCL2/CXCL14/RAC3/CRK/CCL18/CCL3L1/RAF1/SHC1/RELA/CCR7/VAV3/BAD/PARD3/GNAQ/ROCK2/HRAS	1.13550682443131
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/678	157/9376	1.32123330139226	TEAD4/BIRC5/PPP1CC/WNT7A/YAP1/CTNNA1/CSNK1D/PPP2R1A/DLG3/SAV1/DLG1/PARD3/BMPR2/DLG5/TEAD3	1.1332331317232
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/678	86/9376	1.44721136036221	CRK/RAF1/SHC1/MAP2K2/RPS6KB2/BAD/MAPK9/HRAS/RPS6KB1	1.163174785688
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	29/678	333/9376	1.2043193636114	CCNE1/HLA-G/CCNA2/LAMB1/WNT7A/LAMA4/COL4A1/IFNAR2/RAF1/ATP6V1B1/TP53/PPP2R1A/DLG3/RBPJ/MAP2K2/ATP6V1E1/HDAC2/RELA/ISG15/PTEN/DLG1/RPS6KB2/BAD/PARD3/HRAS/HDAC1/TUBG1/NFX1/RPS6KB1	1.05990309916342
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/678	41/9376	1.68645226275272	ALAS2/PHGDH/GLDC/GCSH/PSAT1	1.22980397263527
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/678	41/9376	1.68645226275272	RAF1/TP53/MAP2K2/HRAS/MMP2	1.22980397263527
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/678	31/9376	1.78437529736416	GLDC/ACO1/PGP/GCSH	1.22125367985312
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/678	31/9376	1.78437529736416	SRP54/SGTA/SRP19/SRP68	1.22125367985312
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/678	137/9376	1.31223219860905	BIRC5/CAPN1/CAPN2/RAF1/ENDOG/TP53/EIF2S1/TNFSF10/MAP2K2/RELA/BAD/MAPK9/HRAS	1.02781812197244
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	16/678	174/9376	1.27162377513308	TUSC3/CAPN1/SEC23B/CAPN2/RAD23B/UBXN6/EIF2S1/SAR1A/NSFL1C/SEC24A/UBE2J2/NPLOC4/PRKCSH/SEC24C/MAPK9/HYOU1	1.00969934390949
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/678	77/9376	1.43676971995556	RAC3/RAF1/TP53/RELA/RPS6KB2/BAD/MAPK9/RPS6KB1	1.07441124351639
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/678	32/9376	1.72861356932153	GALK1/B4GALT1/HK1/HK2	1.15264776577529
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/678	90/9376	1.38289085545723	RB1CC1/STK11/TP53/RELA/RPS6KB2/ATF2/EHMT1/HRAS/RPS6KB1	1.01899650110123
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/678	139/9376	1.29335115978014	KRT18/KRT19/KRT23/CALM1/GNAI1/RAF1/SHC1/MAP2K2/GNAQ/ATF2/HRAS/MMP2/NCOA3	0.972793189259597
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/678	67/9376	1.44481134152248	CALM1/PPP1CC/RAF1/MAP2K2/PPP3CA/GNAQ/HRAS	1.02012295852483
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/678	103/9376	1.34261248102643	GNAI1/CCL2/TLR4/CCL3L1/TLR2/PPP2R1A/RELA/GNAQ/MAPK9/NOS2	0.976118279486001
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/678	44/9376	1.57146688120139	RAB5A/DCTN1/DCTN4/NSF/VAMP2	1.06076900883013
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/678	140/9376	1.28411293721028	RPS6/MYL4/CALM1/GNAI1/RAF1/MAP2K2/HDAC5/RPS6KB2/GNAQ/EGR1/HRAS/RPS6KB1/NOS2	0.945592130345465
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/678	116/9376	1.31136201810599	CLDN10/JAM3/GNAI1/CLDN6/CLDN3/CTNNA1/VAV3/THY1/ROCK2/MMP2/CDH5	0.942062937619842
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	18/678	204/9376	1.22019781363873	RPS6/CAV1/IGF2/PPP1CC/WNT7A/TLR4/RAF1/TLR2/TP53/MAP2K2/CAV2/RPS6KB2/VAV3/ROCK2/HRAS/MMP2/RPS6KB1/SDC4	0.887742162250162
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	23/678	268/9376	1.18680931625061	COX8C/RPS27A/CALM1/GNAI1/UBA52/PSMD6/PSMD3/TUBB6/UBA7/PSMD12/SLC39A10/TP53/EIF2S1/KEAP1/SLC39A4/NDUFA5/NDUFS4/UBE2J2/MFN1/MAPK9/PSMD11/PSMD13/NDUFC1	0.866253895000753
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/678	93/9376	1.33828147302312	CGA/CALM1/RAF1/MAP2K2/GNAQ/EGR1/MAPK9/HRAS/MMP2	0.915305971116799
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/678	180/9376	1.22923631596198	HLA-G/CCL2/PPP1CC/EIF2B2/IFNAR2/TLR2/SRSF6/TP53/EIF2S1/RELA/SRSF1/EIF2B4/EIF2B3/BAD/OAS1/EIF2B1	0.866983785022125
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/678	23/9376	1.80377068103117	PMVK/FNTA/DHDDS	1.07748540156571
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/678	69/9376	1.40293275191313	RAC3/RAF1/MAP2K2/VAV3/MAPK9/HRAS/INPP5D	0.9378708587951
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/678	106/9376	1.30461401458229	CCNE1/GSTP1/RAF1/TP53/MAP2K2/RELA/PTEN/BAD/HRAS/ETV5	0.880549407864827
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/678	70/9376	1.38289085545723	LEP/SLC2A1/RXRA/STK11/RELA/ACSL4/MAPK9	0.897704234229394
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	32/678	388/9376	1.14052854058328	COX8C/GAPDH/CAPN1/CALM1/WNT7A/PPID/PSMD6/CAPN2/PSMD3/RAF1/RB1CC1/TUBB6/APP/PSMD12/SLC39A10/EIF2S1/MAP2K2/PPP3CA/SLC39A4/NDUFA5/NDUFS4/RELA/WIPI1/LRP6/BAD/GNAQ/MAPK9/HRAS/PSMD11/PSMD13/NOS2/NDUFC1	0.789295543012249
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/678	13/9376	2.12752439301112	PRKDC/XRCC4	1.13574515850682
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	13/678	144/9376	1.24844313339889	PUM1/PSMD6/GTF2B/PSMD3/RB1CC1/NOP56/PSMD12/RBPJ/WIPI1/GNAQ/MAPK9/PSMD11/PSMD13	0.838785915915387
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/678	120/9376	1.26764995083579	CALM1/CRK/RAPGEF1/RAF1/SHC1/TP53/MAP2K2/RELA/BAD/MAPK9/HRAS	0.823828669491764
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/678	71/9376	1.36341351946487	CGA/RAF1/SHC1/MAP2K2/RELA/MAPK9/HRAS	0.858149292361883
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/678	59/9376	1.40632968351582	RRM2/TYMS/NT5C3A/NME6/NT5C/NUDT2	0.874092293881911
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/678	133/9376	1.24772107259299	CCNB1/RAF1/STK11/PLK1/CCNB2/TNFSF10/MAP2K2/S1PR4/SKP2/PTEN/MAPK9/HRAS	0.803291329250849
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/678	36/9376	1.53654539495247	GYG2/GPI/HK1/HK2	0.900482065323446
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/678	60/9376	1.38289085545723	RAC3/RAF1/MAP2K2/PPP3CA/BAD/HRAS	0.8306664366153
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/678	60/9376	1.38289085545723	GNAI1/RAF1/PPP2R1A/MAP2K2/GNAQ/HRAS	0.8306664366153
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/678	14/9376	1.9755583649389	ST3GAL1/B4GALT1	1.01982050546139
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/678	37/9376	1.49501714103484	HBA1/HBA2/LAMA4/GNAQ	0.842290098467092
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/678	61/9376	1.36022051356449	TRPM7/MT1G/ATP2B3/SLC39A4/MT1E/HMOX1	0.788011784727642
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/678	253/9376	1.14785406974711	RPS27A/CAPN1/PPID/UBE2V2/CRK/UBA52/TLR4/CAPN2/RRAGA/TP53/RELA/WIPI1/RPS6KB2/HK1/NAIP/ROCK2/MAPK9/CYTH2/HK2/SQSTM1/RPS6KB1	0.66560333573185
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/678	163/9376	1.18775901695713	CCNE1/CCNA2/BIRC5/TLR4/RAF1/TLR2/TP53/MAP2K2/RELA/DDB1/BAD/ATF2/MAPK9/HRAS	0.675126029998757
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/678	62/9376	1.33828147302312	HDAC2/RPS6KB2/HRAS/HDAC1/EIF4EBP2/RPS6KB1	0.746099457912669
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/678	15/9376	1.84385447394297	AK5/NTPCR	0.91315152270528
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/678	75/9376	1.29069813176008	GAPDH/PHGDH/GOT1/ACO1/BCAT2/IDH1/PSAT1	0.70566541611434
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	25/678	308/9376	1.12247634371528	COX8C/PSMD6/PSMD3/RB1CC1/DCTN3/TUBB6/GPX8/DCTN1/DCTN4/POLR2C/PSMD12/TP53/POLR2K/NDUFA5/NDUFS4/HDAC2/WIPI1/GNAQ/AP2A1/MAPK9/PSMD11/PSMD13/HDAC1/RCOR1/NDUFC1	0.610186505581746
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/678	63/9376	1.31703890995926	PTGDS/PLA2G2A/PTGR1/HPGD/LTC4S/HPGDS	0.704902129972493
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/678	76/9376	1.27371526160534	CALM1/RAF1/SHC1/TP53/MAP2K2/PTEN/HRAS	0.668890639540405
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/678	39/9376	1.41834959534075	TYMS/MTHFS/GLDC/GCSH	0.730901344575069
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/678	89/9376	1.24304795996155	CDK1/GNAI1/RAF1/TUBB6/CSNK1D/MAP2K2/GNAQ/HRAS	0.643191126401566
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/678	115/9376	1.20251378735411	NACA/GCM1/GNAI1/GATA3/RAF1/RXRA/LRP6/GNAQ/EGR1/ATF2	0.610049895873038
NA	NA	hsa04519	Cadherin signaling	32/678	404/9376	1.09535909343147	KRT18/KRT19/KRT7/KRT8/KRT23/DSP/TEAD4/PPP1CC/WNT7A/RAC3/YAP1/DSG2/CTNNA1/NCKAP1/ENAH/RAF1/MPDZ/MAP2K2/MYO1B/RELA/SAV1/RERE/DSC3/LRP6/VAV3/ROCK2/PKP3/MAPK9/HRAS/TEAD3/CDH5/MYO1C	0.547014636832883
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/678	16/9376	1.72861356932153	MIF/GOT1	0.814348133841651
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/678	103/9376	1.20835123292379	LAMB1/LAMA4/COL4A1/TLR4/RAB5A/TLR2/RELA/GNAQ/NOS2	0.593601979709158
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/678	194/9376	1.14052854058328	TPM1/MYL4/KIF23/KIF2C/MYH10/DCTN3/TUBB6/DCTN1/DCTN4/MYO1B/KIF2A/TNNI2/KIF14/TUBG1/KIF3B/MYO1C	0.552188732148336
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/678	168/9376	1.15240904621436	HMGB1/CAPN1/PPID/TLR4/IFNAR2/TRPM7/CAPN2/CHMP4B/CHMP2B/TNFSF10/VPS4A/MAPK9/DNM1L/SQSTM1	0.556510694056455
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/678	78/9376	1.24105589592315	CAV1/CRK/CTNNA1/DNM2/SHC1/CD2AP/CAV2	0.596844329581037
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/678	130/9376	1.17013841615612	GNAI1/COL4A1/RAF1/SHC1/MAP2K2/RELA/ATF2/MAPK9/HRAS/MMP2/NOS2	0.545365801107986
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/678	79/9376	1.22534632762033	ATP6V1B1/DNM2/NSF/ATP6V1E1/VAMP2/STX3/AP2A1	0.561543492276058
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/678	54/9376	1.28045449579373	PHGDH/GOT1/BCAT2/PSAT1/CISD1	0.57702618346171
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/678	67/9376	1.23840972130498	GAPDH/PDHB/GPI/PDHA1/HK1/HK2	0.546764903534786
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/678	42/9376	1.31703890995926	SLC7A11/TP53/ACSL4/HMOX1	0.574902366732535
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/678	173/9376	1.11910242638157	CCL2/TLR4/IFNAR2/RAF1/XPO1/KPNA6/TRIM25/RAE1/EIF2S1/TNFSF10/MAP2K2/RELA/NXT1/OAS1	0.441438017923915
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/678	227/9376	1.09656543604538	HLA-G/CALM1/GNAI1/CCL2/RAC3/CRK/CCL3L1/RAF1/TP53/MAP2K2/PPP3CA/RELA/RPS6KB2/GNAQ/ATF2/ROCK2/HRAS/RPS6KB1	0.411186269582122
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/678	69/9376	1.20251378735411	CALM1/PPP1CC/PPP3CA/HDAC2/ATF2/HDAC1	0.471373396086195
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/678	148/9376	1.12126285577613	WNT7A/RAF1/SHC1/TP53/MAP2K2/NFKB2/LRP6/PTEN/RPS6KB2/HRAS/NCOA3/RPS6KB1	0.415141012330058
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/678	109/9376	1.14183648615734	NR1H2/PPP1CC/SLC2A1/SLC27A6/RELA/PTEN/RPS6KB2/MAPK9/RPS6KB1	0.415836315845856
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	17/678	216/9376	1.08838632142467	CALM1/CCL2/TLR4/CCL3L1/RXRA/TLR2/TP53/EIF2S1/TNFSF10/PPP3CA/RELA/VAV3/BAD/HSPA2/ROCK2/MAPK9/HRAS	0.366906141632079
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/678	110/9376	1.131456154465	ZFYVE16/E2F4/ID4/PPP2R1A/HDAC2/RPS6KB2/BMPR2/HDAC1/RPS6KB1	0.38718801139468
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/678	150/9376	1.10631268436578	CCNE1/WNT7A/CTNNA1/RAF1/RXRA/SHC1/TP53/MAP2K2/LRP6/RPS6KB2/HRAS/RPS6KB1	0.36645003875939
NA	NA	hsa04382	Cornified envelope formation	17/678	217/9376	1.08337071625681	KRT18/KRT19/KRT7/KRT8/CLDN10/KRT23/DSP/CAPN1/CLDN6/COL4A1/CLDN3/DSG2/KDSR/PPP2R1A/BLMH/PKP3/S100A9	0.346904675754713
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/678	205/9376	1.07932944816174	COX8C/GAPDH/PPP1CC/SLC2A1/MPC2/PDHB/PDHA1/G6PD/NDUFA5/NDUFS4/RELA/PTEN/MAPK9/PDK2/MMP2/NDUFC1	0.320622355569127
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/678	72/9376	1.15240904621436	AZI2/PIN1/TRIM25/RELA/ISG15/MAPK9	0.362437333074248
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/678	112/9376	1.11125158027813	GNAI1/LAMB1/LAMA4/TLR4/TLR2/RELA/BAD/MAPK9/NOS2	0.330679072066955
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/678	99/9376	1.11748755996544	RAC3/RAF1/CHKA/MAP2K2/RPS6KB2/MAPK9/HRAS/RPS6KB1	0.328092638971742
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/678	20/9376	1.38289085545723	UGDH/UAP1	0.478559199238526
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/678	73/9376	1.13662262092375	RAF1/TP53/MAP2K2/PTEN/BAD/HRAS	0.327162347314365
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/678	73/9376	1.13662262092375	RAF1/RXRA/TP53/MAP2K2/BAD/HRAS	0.327162347314365
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	18/678	235/9376	1.05923554886085	RPS6/COX8C/SMARCE1/SMARCA4/NDUFAF4/SMARCD1/COA6/NDUFA5/NDUFS4/RPS6KB2/ATF2/ACSL4/HRAS/NDUFAF2/COX20/RPS6KB1/SMARCB1/NDUFC1	0.256749896383714
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/678	154/9376	1.07757728996667	ALAS2/COQ4/PANK2/AK5/NME6/PANK3/COQ6/BCAT2/COQ5/PSAT1/MMAB/UGDH	0.271002432518609
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/678	128/9376	1.08038348082596	RRM2/GMPR2/NUDT16/AK5/NME6/NT5C/HPRT1/NUDT2/NTPCR/PDE7A	0.255645802389126
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/678	183/9376	1.05794928832793	IMP3/REXO2/RPP30/NOP56/XPO1/GTPBP4/NXT1/FBL/UTP6/RBM28/NOB1/MPHOSPH10/RPP25L/REXO1	0.221022152978312
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/678	212/9376	1.04369121166583	PGF/CALM1/GNAI1/RAC3/CRK/RAPGEF1/RAPGEF2/ENAH/RAF1/KRIT1/MAP2K2/VAV3/PARD3/GNAQ/EFNA1/HRAS	0.179642984918091
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	11/678	144/9376	1.05637495902983	WNT7A/RIF1/DLX5/DUSP9/RAF1/ID4/MAP2K2/TBX3/BMPR2/SMARCAD1/HRAS	0.190331368782911
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/678	187/9376	1.0353193570268	CCL2/TLR4/IFNAR2/TRPM7/TRIP6/BRCC3/GSDMD/SUGT1/RELA/MFN1/OAS1/NAIP/MAPK9/DNM1L	0.136204121626635
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/678	36/9376	1.15240904621436	GALNT2/ST3GAL1/C1GALT1	0.255787513973978
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/678	133/9376	1.03976756049416	HLA-G/RAC3/IFNAR2/RAF1/SHC1/TNFSF10/MAP2K2/PPP3CA/VAV3/HRAS	0.12895526487123
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/678	78/9376	1.06376219650556	CDIPT/ISYNA1/IP6K2/PTEN/PIK3C2A/INPP5D	0.157872535248451
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/678	78/9376	1.06376219650556	CALM1/GNAI1/TLR4/RELA/MAPK9/NOS2	0.157872535248451
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/678	23/9376	1.20251378735411	GOT1/NOS2	0.271477493070409
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/678	134/9376	1.03200810108748	CALD1/PLA2G2A/CALM1/PPP1CC/MYH10/RAF1/PPP1R14A/MAP2K2/GNAQ/ROCK2	0.104188577961155
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/678	65/9376	1.06376219650556	CGA/RAF1/MAP2K2/GNAQ/HRAS	0.144016604691824
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/678	93/9376	1.0408855901291	RAC3/CTNNA1/KRIT1/PARD3/ROCK2/ARHGAP29/CDH5	0.110626291305162
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/678	107/9376	1.03393708819232	CALM1/SLC2A1/PDHB/PDHA1/PPP3CA/GNAQ/ATF2/PPP4C	0.0985691038796234
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/678	233/9376	1.00897616063403	TPM1/MYL4/DSP/COL4A1/MYH10/DSG2/TMOD3/CSRP2/PDLIM1/INF2/DIAPH3/FHL2/VCAN/TNNI2/SYNE2/CSRP1/SDC4	0.0387360203319027
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/678	94/9376	1.02981233917028	CCL2/ANAPC5/USP25/RELA/SRSF1/MAPK9/S100A9	0.081101704484451
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/678	38/9376	1.09175593851886	SIRT7/NMRK1/NT5C	0.158230364565333
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/678	122/9376	1.02016538517336	RAF1/PPP2R1A/MAP2K2/PPP3CA/RELA/DLG1/VAV3/MAPK9/HRAS	0.0625910839889748
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/678	122/9376	1.02016538517336	GNAI1/CRK/RAF1/SHC1/MAP2K2/GNAQ/ATF2/MAPK9/HRAS	0.0625910839889748
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/678	136/9376	1.01683151136561	CCNE1/TLR4/IFNAR2/TLR2/TP53/EIF2S1/RELA/BAD/OAS1/MAPK9	0.0552010535642467
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/678	10/9376	1.38289085545723	SELENBP1	0.33821175733613
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/678	53/9376	1.04369121166583	DNM2/ATP2B3/GNAQ/AP2A1	0.0890522639945468
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/678	166/9376	0.999680136475104	CALM1/GNAI1/PPP1CC/RAF1/ADRA2C/MAP2K2/ATP2B3/PPP3CA/BAD/GNAQ/ATF2/ROCK2	-0.00116085969093605
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/678	138/9376	1.00209482279509	CCL2/RAC3/CRK/TLR4/MAP2K2/RELA/VAV3/GNAQ/ROCK2/MAPK9	0.00692131537742603
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/678	82/9376	1.01187135765163	RRM2/GSTP1/NME6/HPRT1/GSTA4/GSTM4	0.030143714297257
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/678	83/9376	0.999680136475104	AURKB/RING1/USP16/HDAC2/HDAC1/ASXL1	-0.000817177837926689
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/678	98/9376	0.987779182469448	CRK/RAF1/DNM2/RPS6KB2/VAV3/INPP5D/RPS6KB1	-0.0339529017632234
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/678	56/9376	0.987779182469448	TUSC3/DPM3/B4GALT1/ALG13	-0.0256080848702706
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/678	71/9376	0.973866799617766	JAM3/ATP6V1B1/ATP6V1E1/RELA/MAPK9	-0.0617098325020723
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/678	100/9376	0.968023598820059	CCL13/CCL2/CXCL14/CCL18/CCL3L1/TNFSF10/CCR7	-0.0897511449356536
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/678	12/9376	1.15240904621436	NPC1	0.147489617467589
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/678	101/9376	0.958439206752534	CALM1/GNAI1/WNT7A/RAF1/MAP2K2/GNAQ/HRAS	-0.117240682866499
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/678	101/9376	0.958439206752534	CCL2/COL4A1/RELA/EGR1/MAPK9/HRAS/MMP2	-0.117240682866499
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/678	43/9376	0.96480757357481	ECI2/ACSL4/GCDH	-0.0645748773057833
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/678	28/9376	0.987779182469448	ATP6V1B1/ATP6V1E1	-0.0180805112669195
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	15/678	217/9376	0.955915337873659	BIRC5/GNAI1/RAF1/RXRA/KPNA6/MAP2K2/RELA/GSTA4/GSTM4/RPS6KB2/BAD/ATF2/HRAS/CDC6/RPS6KB1	-0.183435816643166
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/678	44/9376	0.942880128720837	TUSC3/B4GALT1/ALG13	-0.106027122891046
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/678	44/9376	0.942880128720837	HMGB1/POLE3/XRCC1	-0.106027122891046
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/678	362/9376	0.955035121172118	CCNE1/RPS6/PGF/IGF2/LAMB1/LAMA4/PIK3AP1/COL4A1/TLR4/IFNAR2/RAF1/RXRA/STK11/TLR2/TP53/PPP2R1A/MAP2K2/RELA/PTEN/RPS6KB2/BAD/ATF2/EFNA1/HRAS/RPS6KB1	-0.243590147995935
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/678	104/9376	0.930791921942364	PLA2G2A/CDIPT/AGPAT3/LYPLA2/AGPAT1/PEMT/CHKA	-0.198142450823535
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/678	105/9376	0.921927236971485	CALM1/RAF1/PPP3CA/NFKB2/RELA/MAPK9/HRAS	-0.224606175005566
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/678	30/9376	0.921927236971485	TYMS/RELA	-0.119574361905488
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/678	46/9376	0.901885340515583	ALAS2/HMOX1/MMAB	-0.186235632553837
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	12/678	181/9376	0.916833716325233	CEBPG/CALM1/TLR4/RAF1/RAB5A/TLR2/RFXANK/PPP3CA/RELA/BAD/MAPK9/NOS2	-0.315428913032402
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/678	31/9376	0.892187648682082	GPI/G6PD	-0.167861266441051
NA	NA	hsa04981	Folate transport and metabolism	2/678	31/9376	0.892187648682082	TYMS/MTHFS	-0.167861266441051
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/678	47/9376	0.882696290717379	PDHB/PDHA1/GLO1	-0.22507844762125
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/678	47/9376	0.882696290717379	HK1/MAPK9/HK2	-0.22507844762125
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/678	15/9376	0.921927236971485	ST3GAL1	-0.0844840723640168
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/678	63/9376	0.878025939972843	AADAT/ASH1L/EHMT1/GCDH	-0.27119628541993
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/678	227/9376	0.913804530037815	COX8C/RAF1/KEAP1/MAP2K2/NDUFA5/NDUFS4/RELA/GSTA4/PTEN/GSTM4/BAD/HMOX1/MAPK9/HRAS/NDUFC1	-0.367029811080368
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/678	109/9376	0.888095044789045	TLR4/CCL3L1/IFNAR2/TLR2/MAP2K2/RELA/MAPK9	-0.32808303110525
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/678	32/9376	0.864306784660767	BIRC5/MAPK9	-0.214663146662605
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/678	154/9376	0.897981074972225	TPM1/MYL4/CALM1/GNAI1/PPP1CC/PPP2R1A/ATP2B3/GNAQ/ATF2/CREM	-0.356384927307188
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/678	79/9376	0.875247376871663	GSTP1/AKR7A2/GSTA4/GSTM4/HPGDS	-0.310872710471302
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/678	184/9376	0.901885340515583	GNAI1/RAC3/EPHB4/ENAH/RAF1/FES/PPP3CA/PARD3/BMPR2/ROCK2/EFNA1/HRAS	-0.375256814915745
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/678	95/9376	0.873404750815091	CCL2/TLR4/CCL3L1/ATP6V1B1/TLR2/ATP6V1E1	-0.346236307687113
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/678	49/9376	0.846667870688098	GALNT2/B4GALT1/C1GALT1	-0.300435329442722
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/678	49/9376	0.846667870688098	GNAI1/RELA/ATF2	-0.300435329442722
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/678	16/9376	0.864306784660767	ST3GAL1	-0.151659976342979
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/678	33/9376	0.838115669974077	VAMP2/STX3	-0.260081458056896
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/678	275/9376	0.905164923572003	COX8C/CAV1/PSMD6/PSMD3/TUBB6/PSMD12/EIF2S1/PPP3CA/NDUFA5/NDUFS4/CAV2/BAD/EGR1/ATF2/MAPK9/PSMD11/PSMD13/NDUFC1	-0.445637338425331
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/678	50/9376	0.829734513274336	GOT1/CKMT1B/NOS2	-0.337019247292153
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/678	66/9376	0.838115669974077	GATA3/TLR4/TLR2/RELA	-0.36846201516396
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/678	34/9376	0.813465209092487	POLR2C/POLR2K	-0.304207666809608
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/678	17/9376	0.813465209092487	ACOT8	-0.214911851249227
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/678	17/9376	0.813465209092487	MYH10	-0.214911851249227
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/678	98/9376	0.846667870688098	CALM1/CDIPT/IP6K2/PTEN/PIK3C2A/INPP5D	-0.426000200940541
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/678	35/9376	0.790223345975558	HK1/HK2	-0.34712450516391
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/678	18/9376	0.768272697476237	ACSL4	-0.274734197637832
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/678	18/9376	0.768272697476237	MMAB	-0.274734197637832
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/678	69/9376	0.801675858236074	CALM1/GNAI1/PPP3CA/GNAQ	-0.461621529331615
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/678	36/9376	0.768272697476237	POLE3/MCM5	-0.388907037375489
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/678	178/9376	0.854595472473567	WNT7A/RAC3/TBL1XR1/APCDD1/TP53/PPP3CA/LRP6/CTBP2/TLE1/ROCK2/MAPK9	-0.54680441383815
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/678	133/9376	0.831814048395325	CALM1/GNAI1/PPP1CC/PPP2R1A/PPP3CA/GNAQ/ATF2/MAPK9	-0.545380799508389
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/678	70/9376	0.790223345975558	GSTP1/GSTA4/GSTM4/HPGDS	-0.491830473034771
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/678	37/9376	0.74750857051742	GOT1/NIT2	-0.429623569309918
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/678	37/9376	0.74750857051742	MIF/GOT1	-0.429623569309918
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/678	195/9376	0.851009757204447	HMGB1/TLR4/RAF1/SELPLG/HAT1/TLR2/GSDMD/MAP2K2/HDAC2/RELA/HDAC5/HDAC1	-0.586976782496136
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/678	226/9376	0.856658052053149	CGA/CALM1/GNAI1/PPP1CC/RAC3/RAF1/MAP2K2/ATP2B3/RELA/VAV3/BAD/ROCK2/MAPK9/GLI3	-0.608986630020934
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/678	196/9376	0.846667870688098	HLA-G/RPS27A/CALM1/UBA52/IFNAR2/RAF1/TP53/MAP2K2/PPP3CA/RELA/MAPK9/HRAS	-0.605662444797789
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/678	20/9376	0.691445427728614	EBP	-0.385649400927194
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/678	89/9376	0.77690497497597	HMMR/LAMB1/LAMA4/COL4A1/SDC4	-0.5903885820004
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/678	89/9376	0.77690497497597	GNAI1/SLC38A1/NSF/TRAK2/SLC38A2	-0.5903885820004
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/678	73/9376	0.757748413949165	GSTP1/GSTA4/GSTM4/HPGDS	-0.580105966326417
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/678	154/9376	0.808182967475003	CALM1/GNAI1/PPP1CC/RAF1/MAP2K2/PPP3CA/GNAQ/ROCK2/HRAS	-0.670078607220086
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/678	21/9376	0.658519454979632	DSEL	-0.437365478373294
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/678	75/9376	0.737541789577188	CGA/GPX8/GNAQ/ATF2	-0.637113424669326
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/678	41/9376	0.674580905101086	BRCC3/NBN	-0.583000038594417
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/678	76/9376	0.727837292345909	GAST/CALM1/GNAI1/GNAQ	-0.665096591670069
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/678	109/9376	0.761224324104896	GATA3/RXRA/PPP3CA/RELA/RUNX1/MAPK9	-0.700042704580803
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/678	157/9376	0.792739980835353	NR1H2/SLC2A1/CRK/RAB5A/RXRA/STAB1/MAP2K2/ANO6/VPS39	-0.731163050595931
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/678	157/9376	0.792739980835353	LEP/COX8C/RXRA/EIF2S1/NDUFA5/NDUFS4/RELA/MAPK9/NDUFC1	-0.731163050595931
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/678	93/9376	0.743489707235068	GATA3/RBPJ/PPP3CA/RELA/MAPK9	-0.694053388506475
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/678	142/9376	0.779093439694213	IFNAR2/LILRB1/PPP3CA/NFKB2/RELA/FHL2/MAPK9/SQSTM1	-0.740540191309589
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/678	42/9376	0.658519454979632	AADAT/GCDH	-0.619223594827999
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/678	23/9376	0.601256893677055	B4GALT1	-0.53453041542489
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/678	23/9376	0.601256893677055	MSH3	-0.53453041542489
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/678	191/9376	0.79642928848322	CALM1/GNAI1/PPP1CC/RAF1/SHC1/HAT1/HDAC2/HDAC5/ATF2/HRAS/HDAC1	-0.793566235662144
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/678	78/9376	0.709174797670373	TLR4/TLR2/RELA/NOS2	-0.72007105341672
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/678	238/9376	0.813465209092487	PLA2G2A/PGF/CALM1/IGF2/RAC3/RAF1/RAB5A/SHC1/MAP2K2/RELA/BAD/EFNA1/MAPK9/HRAS	-0.813792212886363
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/678	160/9376	0.77787610619469	HLA-G/CLDN10/JAM3/CLDN6/CLDN3/SELPLG/VCAN/SDC4/CDH5	-0.79117912450994
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/678	43/9376	0.643205049049873	PLA2G2A/AGPAT1	-0.654686036778516
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	18/678	300/9376	0.829734513274336	PGF/IGF2/RAC3/CRK/RAPGEF2/DUSP9/RAF1/TP53/MAP2K2/PPP3CA/MKNK2/NFKB2/RELA/ATF2/EFNA1/MAPK9/HRAS/MAPKAPK5	-0.836817572470412
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/678	63/9376	0.658519454979632	WNT7A/TP53/GLI3	-0.759245493116141
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/678	98/9376	0.705556558906749	CYP11A1/CALM1/ATP2B3/GNAQ/ATF2	-0.818047500117859
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/678	45/9376	0.61461815798099	ABCD3/ABCB10	-0.723476108428308
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/678	149/9376	0.742491734473679	AGPAT3/RAF1/DNM2/SHC1/AGPAT1/MAP2K2/HRAS/CYTH2	-0.884595714370986
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/678	82/9376	0.674580905101086	HLA-G/RFXANK/PSME3/HSPA2	-0.826303150099959
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/678	323/9376	0.813465209092487	TPM1/CCNE1/IGF2BP1/KIF23/CRK/RAF1/SHC1/TP53/MAP2K2/CDC25C/HDAC2/PTEN/HDAC5/BMPR2/HMOX1/EFNA1/HRAS/HDAC1/CDCA5	-0.95247948221913
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/678	26/9376	0.53188109825278	PLA2G2A	-0.66731030184486
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/678	65/9376	0.638257317903336	CYP11A1/GNAQ/ATF2	-0.817050787187565
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/678	83/9376	0.666453424316736	GSDMD/POLR2K/G3BP1/RELA	-0.852134889882423
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/678	27/9376	0.512181798317492	ELOVL6	-0.708676589587004
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/678	201/9376	0.756805940797488	CCNA2/LYL1/RXRA/HPGD/TP53/HDAC2/RELA/RUNX1/HDAC1/ASPSCR1/ETV5	-0.973058022075323
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/678	48/9376	0.576204523107178	HIBADH/BCAT2	-0.821813839686717
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/678	48/9376	0.576204523107178	HK1/HK2	-0.821813839686717
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/678	86/9376	0.643205049049873	SLC2A1/VAMP2/GNAQ/ATF2	-0.928006145170013
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/678	28/9376	0.493889591234724	ELOVL6	-0.748782552812762
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/678	28/9376	0.493889591234724	B4GALT1	-0.748782552812762
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/678	155/9376	0.713750118945666	HLA-G/TLR4/RAB5A/ATP6V1B1/TUBB6/TLR2/HGS/ATP6V1E1	-1.00325870442677
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/678	87/9376	0.635811887566541	TPM1/MYL4/COX8C/ASPH	-0.952777941933278
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/678	122/9376	0.680110256782243	LEP/CCNA2/STK11/PPP2R1A/RPS6KB2/RPS6KB1	-0.992901728026544
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/678	105/9376	0.658519454979632	CCL13/TLR4/TRIM25/NFKB2/RELA	-0.982399444833628
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/678	29/9376	0.476858915674906	CALM1	-0.787721119223927
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/678	70/9376	0.592667509481669	HLA-G/CAV1/RAC3	-0.955008708789492
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/678	51/9376	0.542310139394991	PLA2G2A/PAFAH1B3	-0.915003473463621
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/678	51/9376	0.542310139394991	ATP6V1B1/ATP6V1E1	-0.915003473463621
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/678	30/9376	0.460963618485742	PLA2G2A	-0.825575128420512
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/678	52/9376	0.53188109825278	CGA/CYP11A1	-0.945034145112349
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/678	31/9376	0.446093824341041	UGDH	-0.862418739588137
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/678	32/9376	0.432153392330383	SUCLA2	-0.898318602881552
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/678	32/9376	0.432153392330383	WIPI1	-0.898318602881552
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/678	54/9376	0.512181798317492	CGA/HLA-G	-1.00367039702241
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/678	93/9376	0.594791765788055	CALM1/ATP2B3/VAMP2/GNAQ	-1.09639322841229
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/678	55/9376	0.502869401984446	KDSR/CERS5	-1.03231293394309
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/678	232/9376	0.715288373512359	PPP1CC/RAC3/MYH10/CRK/NCKAP1/ENAH/RAF1/MAP2K2/DIAPH3/VAV3/ROCK2/HRAS	-1.22594749220778
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/678	76/9376	0.545877969259432	RXRA/SLC27A6/ACSL4	-1.10975900207356
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/678	56/9376	0.493889591234724	CSNK1D/GLI3	-1.06052792859292
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/678	34/9376	0.406732604546243	CSNK1D	-0.967521872392604
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/678	57/9376	0.485224861563939	ELOVL6/ACSL4	-1.08833130001544
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/678	115/9376	0.601256893677055	GNAI1/RAF1/APP/GNAQ/HRAS	-1.20116854101917
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/678	116/9376	0.596073644593632	GNAI1/SLC38A1/PPP3CA/GNAQ/SLC38A2	-1.22212738493577
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/678	36/9376	0.384136348738119	UGDH	-1.03360158872496
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/678	59/9376	0.468776561171941	CGA/GNAI1	-1.1427624735444
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/678	99/9376	0.558743779982718	CALM1/PPP1CC/GNAQ/MAPK9	-1.23224039830904
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/678	99/9376	0.558743779982718	KRT18/KRT19/KRT23/SELPLG	-1.23224039830904
NA	NA	hsa04518	Integrin signaling	7/678	154/9376	0.628586752480558	PGF/LAMB1/LAMA4/COL4A1/RAC3/FERMT2/PARVA	-1.29746596704588
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/678	155/9376	0.624531354077457	CCNE1/CYP11A1/GNAI1/WNT7A/MAP2K2/GNAQ/ATF2	-1.31595578616022
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/678	119/9376	0.581046577923205	CCL2/RELA/ATF2/MAPK9/DNM1L	-1.28408825727255
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/678	138/9376	0.601256893677055	COX8C/ATP6V1B1/ATP6V1E1/NDUFA5/NDUFS4/NDUFC1	-1.31745119439293
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/678	38/9376	0.363918646172954	RFXANK	-1.09690322102228
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/678	103/9376	0.537044992410574	COL4A1/SLC36A4/COL21A1/SLC38A2	-1.31897951917506
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/678	39/9376	0.354587398835186	HLA-G	-1.12760462362305
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/678	86/9376	0.482403786787405	DSP/DSG2/CTNNA1	-1.34624233134162
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/678	65/9376	0.425504878602224	AGPAT3/AGPAT1	-1.29758448312726
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/678	149/9376	0.556868800855259	GNAI1/NDUFA5/NDUFS4/GNAQ/MAPK9/NDUFC1	-1.5222500095922
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/678	44/9376	0.314293376240279	HLA-G	-1.27282325461223
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/678	45/9376	0.307309078990495	HLA-G	-1.30038646670555
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/678	97/9376	0.42769820271873	CALM1/GNAI1/GNAQ	-1.58179854974893
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/678	250/9376	0.60847197640118	AP1M2/CLCN7/ATP6V1B1/DTNBP1/RRAGA/ATP6V1E1/SLC36A4/BLOC1S4/NPC1/AP2A1/VPS39	-1.7517955052582
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/678	52/9376	0.26594054912639	NPC1	-1.4819124863977
NA	NA	hsa04081	Hormone signaling	9/678	219/9376	0.568311310461874	CGA/GAST/LEP/GNAI1/IGF2/DIO2/ADRA2C/STK11/GNAQ	-1.80470783529716
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/678	102/9376	0.406732604546243	PLA2G2A/ATP2B3/GNAQ	-1.6819295654188
Organismal Systems	Immune system	hsa04611	Platelet activation	4/678	126/9376	0.439012969986421	GNAI1/PPP1CC/GNAQ/ROCK2	-1.76993782332035
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/678	298/9376	0.603274534259864	LEP/CCL13/CCL2/CXCL14/CCL18/CCL3L1/IFNAR2/RELT/TNFSF10/CCR7/CSF2RA/BMPR2/GDF11	-1.94309442157893
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/678	88/9376	0.314293376240279	TFPI/SERPINB2	-1.80430254143268
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/678	90/9376	0.307309078990495	SLC2A1/RXRA	-1.84347475212065
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/678	115/9376	0.360754136206233	GNAI1/GNAQ/HRAS	-1.92565591577606
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/678	91/9376	0.303932056144446	GNAI1/PDE7A	-1.86282543506741
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/678	66/9376	0.209528917493519	CYP11A1	-1.799177029318
NA	NA	hsa04517	IgSF CAM signaling	12/678	299/9376	0.555006363394205	JAM3/MYH10/RAPGEF2/TUBB6/APP/MPDZ/CD2AP/MAP2K2/VAV3/PARD3/MAPK9/INPP5D	-2.18327785899495
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/678	144/9376	0.384136348738119	TLR4/TRA2A/RELA/MAPK9	-2.07925954618076
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/678	168/9376	0.41157465936227	LEP/IFNAR2/RAF1/CSF2RA/HRAS	-2.14859290083179
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/678	100/9376	0.276578171091445	GYPA/CSF2RA	-2.03049545978041
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/678	99/9376	0.13968594499568	TPM1	-2.40249017626962
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/678	105/9376	0.131703890995926	TPM1	-2.49798598448975
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/678	254/9376	0.326667131210369	CALM1/ASPH/ATP2B3/PPP3CA/GNAQ/NOS2	-3.0373330995673
NA	NA	hsa04082	Neuroactive ligand signaling	3/678	199/9376	0.208476008360386	GNAI1/ADRA2C/GNAQ	-3.15087401759248
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/678	143/9376	0.0967056542277781	TRIM21	-3.03890186847578
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/678	370/9376	0.186877142629355	CGA/LEP/ADRA2C/S1PR4/GZMA	-4.45535017454371
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/678	449/9376	0.0307993509010518	CALM1	-5.87590658683897