ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 101/1269 175/18639 0.577142857142857 8.47704154002026 9.16507866881838e-72 9.79746909696685e-69 GO:0019843 rRNA binding 27/1269 65/18639 0.415384615384615 6.10114566284779 2.77528602315024e-15 1.4833903793738e-12 GO:0045296 cadherin binding 52/1269 334/18639 0.155688622754491 2.28674565762093 1.74217758869344e-08 4.80418522435785e-06 GO:0031720 haptoglobin binding 8/1269 10/18639 0.8 11.7503546099291 1.79763712791687e-08 4.80418522435785e-06 GO:0003712 transcription coregulator activity 67/1269 495/18639 0.135353535353535 1.98806504763952 5.04988001057986e-08 1.07966434626197e-05 GO:0048027 mRNA 5'-UTR binding 11/1269 24/18639 0.458333333333333 6.73197399527187 1.52499918259198e-07 2.71704021031804e-05 GO:0003713 transcription coactivator activity 41/1269 256/18639 0.16015625 2.35236591312057 2.57250784770622e-07 3.9285869845685e-05 GO:0043021 ribonucleoprotein complex binding 32/1269 177/18639 0.180790960451977 2.6554473694755 3.37396185636178e-07 4.50845653056343e-05 GO:0003743 translation initiation factor activity 15/1269 51/18639 0.294117647058824 4.31998331247393 8.9227258517917e-07 0.000100122318384663 GO:0005344 oxygen carrier activity 8/1269 14/18639 0.571428571428571 8.39311043566363 9.36597926891146e-07 0.000100122318384663 GO:1990948 ubiquitin ligase inhibitor activity 7/1269 11/18639 0.636363636363636 9.34687298517086 1.72624153156607e-06 0.000167759290658557 GO:0055105 ubiquitin-protein transferase inhibitor activity 8/1269 15/18639 0.533333333333333 7.83356973995272 1.88680975552052e-06 0.00016808330238762 GO:0140104 molecular carrier activity 38/1269 249/18639 0.152610441767068 2.24153350992623 2.34559436948642e-06 0.000192880029306229 GO:0055106 ubiquitin-protein transferase regulator activity 12/1269 36/18639 0.333333333333333 4.89598108747045 2.54346428805188e-06 0.000194211665994819 GO:0140658 ATP-dependent chromatin remodeler activity 26/1269 158/18639 0.164556962025316 2.41700332166263 2.37339887670433e-05 0.00159200036078013 GO:0140297 DNA-binding transcription factor binding 58/1269 488/18639 0.118852459016393 1.74569817463086 2.3827881920002e-05 0.00159200036078013 GO:0008135 translation factor activity, RNA binding 17/1269 83/18639 0.204819277108434 3.00837392121678 3.62298310277991e-05 0.00227821702168925 GO:0180051 translation factor activity 17/1269 84/18639 0.202380952380952 2.9725599459642 4.25790556623222e-05 0.00252872280572347 GO:0008017 microtubule binding 37/1269 276/18639 0.134057971014493 1.96903587213485 6.00569638094385e-05 0.00337899443748894 GO:0016887 ATP hydrolysis activity 50/1269 417/18639 0.119904076738609 1.76114427606851 6.80854337067886e-05 0.00360968709328972 GO:0000510 H3-H4 histone complex chaperone activity 24/1269 151/18639 0.158940397350993 2.33450753839651 8.50021111778359e-05 0.00360968709328972 GO:0140584 chromatin extrusion motor activity 24/1269 151/18639 0.158940397350993 2.33450753839651 8.50021111778359e-05 0.00360968709328972 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 24/1269 151/18639 0.158940397350993 2.33450753839651 8.50021111778359e-05 0.00360968709328972 GO:0140849 ATP-dependent H2AZ histone chaperone activity 24/1269 151/18639 0.158940397350993 2.33450753839651 8.50021111778359e-05 0.00360968709328972 GO:0008094 ATP-dependent activity, acting on DNA 30/1269 210/18639 0.142857142857143 2.09827760891591 9.20533647078216e-05 0.00360968709328972 GO:0004601 peroxidase activity 13/1269 57/18639 0.228070175438596 3.34988179669031 9.26762192271132e-05 0.00360968709328972 GO:0015616 DNA translocase activity 24/1269 152/18639 0.157894736842105 2.31914893617021 9.45474636221817e-05 0.00360968709328972 GO:0140674 ATP-dependent histone chaperone activity 24/1269 152/18639 0.157894736842105 2.31914893617021 9.45474636221817e-05 0.00360968709328972 GO:0061775 cohesin loader activity 24/1269 153/18639 0.156862745098039 2.30399109998609 0.000105037259703694 0.0038718907111465 GO:0003714 transcription corepressor activity 29/1269 204/18639 0.142156862745098 2.0879919343624 0.000130550553431137 0.00450684541634565 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 13/1269 59/18639 0.220338983050847 3.23632648154826 0.00013491024632653 0.00450684541634565 GO:0036002 pre-mRNA binding 13/1269 59/18639 0.220338983050847 3.23632648154826 0.00013491024632653 0.00450684541634565 GO:0003724 RNA helicase activity 15/1269 77/18639 0.194805194805195 2.86128764852169 0.000185368560349157 0.00596896989217228 GO:0043022 ribosome binding 19/1269 112/18639 0.169642857142857 2.49170466058764 0.000189845628001738 0.00596896989217228 GO:0003689 DNA clamp loader activity 24/1269 160/18639 0.15 2.2031914893617 0.000212358198805037 0.00648602612921669 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 42/1269 349/18639 0.120343839541547 1.76760348716698 0.000232806875566684 0.00679110922825886 GO:0043024 ribosomal small subunit binding 7/1269 20/18639 0.35 5.14078014184397 0.000235052424177341 0.00679110922825886 GO:0008186 ATP-dependent activity, acting on RNA 15/1269 79/18639 0.189873417721519 2.7888499865338 0.000249255482979105 0.00701195029749113 GO:0140713 histone chaperone activity 24/1269 164/18639 0.146341463414634 2.14945511157239 0.000309937075682988 0.00849545471551575 GO:0043130 ubiquitin binding 17/1269 100/18639 0.17 2.49695035460993 0.000395045858557809 0.0105576005699574 GO:0140597 protein carrier chaperone 26/1269 188/18639 0.138297872340426 2.03131130224838 0.000439212865369487 0.011451672026341 GO:0015631 tubulin binding 44/1269 385/18639 0.114285714285714 1.67862208713273 0.000517263857762062 0.0131655967606582 GO:0044389 ubiquitin-like protein ligase binding 38/1269 322/18639 0.118012422360248 1.73335976388705 0.00065932417712889 0.0163911057058322 GO:0002039 p53 binding 13/1269 69/18639 0.188405797101449 2.76729365813547 0.000683375997243692 0.0166029304784888 GO:0097371 MDM2/MDM4 family protein binding 5/1269 12/18639 0.416666666666667 6.11997635933806 0.000766939147073025 0.0182190655160236 GO:0061791 GTPase motor activity 9/1269 40/18639 0.225 3.30478723404255 0.00121903001512099 0.0277264486417944 GO:1990606 membrane scission GTPase motor activity 9/1269 40/18639 0.225 3.30478723404255 0.00121903001512099 0.0277264486417944 GO:0032182 ubiquitin-like protein binding 18/1269 120/18639 0.15 2.2031914893617 0.00125099213057089 0.0278606372412558 GO:0003697 single-stranded DNA binding 18/1269 121/18639 0.148760330578512 2.18498329523475 0.00137817894655205 0.0300668019155947 GO:0019825 oxygen binding 8/1269 34/18639 0.235294117647059 3.45598664997914 0.0016641468402947 0.0355794594455008 GO:0016209 antioxidant activity 14/1269 86/18639 0.162790697674419 2.39106053109022 0.00191640044002084 0.0398064269982797 GO:0004386 helicase activity 21/1269 155/18639 0.135483870967742 1.98997940974605 0.00193632759954214 0.0398064269982797 GO:0046966 nuclear thyroid hormone receptor binding 7/1269 28/18639 0.25 3.67198581560284 0.00222136651910994 0.0448045435646892 GO:0042809 nuclear vitamin D receptor binding 5/1269 15/18639 0.333333333333333 4.89598108747045 0.00244830439801234 0.0484673592865776 GO:0140097 catalytic activity, acting on DNA 37/1269 336/18639 0.110119047619048 1.61742232353934 0.00265017980992565 0.0515098584874639 GO:0031625 ubiquitin protein ligase binding 34/1269 302/18639 0.112582781456954 1.65360950636419 0.00270543605238438 0.0516448417856947 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/1269 10/18639 0.4 5.87517730496454 0.00321999811460953 0.060308156194595 GO:0140098 catalytic activity, acting on RNA 41/1269 387/18639 0.10594315245478 1.55608701229681 0.00327209827809776 0.060308156194595 GO:0050786 RAGE receptor binding 4/1269 11/18639 0.363636363636364 5.34107027724049 0.00478920107293818 0.0867738296096766 GO:0001221 transcription coregulator binding 16/1269 115/18639 0.139130434782609 2.04353993216158 0.00488284525436799 0.0869960262819897 GO:0016922 nuclear receptor binding 18/1269 137/18639 0.131386861313869 1.92980276440441 0.00544258277466715 0.0953790325593309 GO:0042974 nuclear retinoic acid receptor binding 6/1269 25/18639 0.24 3.52510638297872 0.0056731848635197 0.0978166874048799 GO:0070628 proteasome binding 5/1269 18/18639 0.277777777777778 4.07998423955871 0.0058870640759834 0.0988646792486749 GO:1990841 promoter-specific chromatin binding 11/1269 68/18639 0.161764705882353 2.37599082186066 0.00591893308878877 0.0988646792486749 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/1269 12/18639 0.333333333333333 4.89598108747045 0.00680033203587077 0.109612387891621 GO:0001098 basal transcription machinery binding 10/1269 60/18639 0.166666666666667 2.44799054373522 0.00686999998946546 0.109612387891621 GO:0001099 basal RNA polymerase II transcription machinery binding 10/1269 60/18639 0.166666666666667 2.44799054373522 0.00686999998946546 0.109612387891621 GO:0048306 calcium-dependent protein binding 12/1269 80/18639 0.15 2.2031914893617 0.00766086220433261 0.120433260241641 GO:0003774 cytoskeletal motor activity 19/1269 153/18639 0.124183006535948 1.82399295415566 0.00800700285235128 0.124050522451645 GO:0140296 general transcription initiation factor binding 9/1269 53/18639 0.169811320754717 2.49417904456042 0.00893629498471383 0.136469990552273 GO:0097718 disordered domain specific binding 6/1269 28/18639 0.214285714285714 3.14741641337386 0.0101366664793162 0.152621076991394 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 7/1269 38/18639 0.184210526315789 2.70567375886525 0.0130817197336123 0.194227199933772 GO:0140030 modification-dependent protein binding 20/1269 173/18639 0.115606936416185 1.69802812282212 0.0141175073424889 0.202814665120776 GO:0016769 transferase activity, transferring nitrogenous groups 6/1269 30/18639 0.2 2.93758865248227 0.0142292795921966 0.202814665120776 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/1269 30/18639 0.2 2.93758865248227 0.0142292795921966 0.202814665120776 GO:0140517 protein-RNA adaptor activity 5/1269 22/18639 0.227272727272727 3.33816892327531 0.0144273078658068 0.202931475112467 GO:1901981 phosphatidylinositol phosphate binding 21/1269 185/18639 0.113513513513514 1.66728004600345 0.0146901144209992 0.203944575533093 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1269 15/18639 0.266666666666667 3.91678486997636 0.0159209992912184 0.207555466369664 GO:0031386 protein tag activity 4/1269 15/18639 0.266666666666667 3.91678486997636 0.0159209992912184 0.207555466369664 GO:0141047 molecular tag activity 4/1269 15/18639 0.266666666666667 3.91678486997636 0.0159209992912184 0.207555466369664 GO:0141050 histone H3K deacetylase activity 4/1269 15/18639 0.266666666666667 3.91678486997636 0.0159209992912184 0.207555466369664 GO:0141051 histone H4K deacetylase activity 4/1269 15/18639 0.266666666666667 3.91678486997636 0.0159209992912184 0.207555466369664 GO:0001222 transcription corepressor binding 8/1269 49/18639 0.163265306122449 2.39803155304675 0.0167705392187838 0.21411197096951 GO:0004532 RNA exonuclease activity 7/1269 40/18639 0.175 2.57039007092199 0.0171798547309462 0.21411197096951 GO:0003727 single-stranded RNA binding 12/1269 89/18639 0.134831460674157 1.98039684437007 0.0172850223741091 0.21411197096951 GO:0044013 histone H2B acetyltransferase activity 5/1269 23/18639 0.217391304347826 3.19303114400247 0.0174253895924672 0.21411197096951 GO:0070577 lysine-acetylated histone binding 5/1269 23/18639 0.217391304347826 3.19303114400247 0.0174253895924672 0.21411197096951 GO:0031369 translation initiation factor binding 6/1269 32/18639 0.1875 2.75398936170213 0.0193491552198771 0.231120809407789 GO:0016877 ligase activity, forming carbon-sulfur bonds 7/1269 41/18639 0.170731707317073 2.50769763016779 0.0195356179936026 0.231120809407789 GO:0003688 DNA replication origin binding 4/1269 16/18639 0.25 3.67198581560284 0.0201068618100322 0.231120809407789 GO:0005159 insulin-like growth factor receptor binding 4/1269 16/18639 0.25 3.67198581560284 0.0201068618100322 0.231120809407789 GO:0030275 LRR domain binding 4/1269 16/18639 0.25 3.67198581560284 0.0201068618100322 0.231120809407789 GO:0097027 ubiquitin-protein transferase activator activity 4/1269 16/18639 0.25 3.67198581560284 0.0201068618100322 0.231120809407789 GO:0035035 histone acetyltransferase binding 5/1269 24/18639 0.208333333333333 3.05998817966903 0.020808225027699 0.23298614942118 GO:0140033 acetylation-dependent protein binding 5/1269 24/18639 0.208333333333333 3.05998817966903 0.020808225027699 0.23298614942118 GO:0016853 isomerase activity 20/1269 180/18639 0.111111111111111 1.63199369582348 0.0209229844194885 0.23298614942118 GO:0004402 histone acetyltransferase activity 7/1269 42/18639 0.166666666666667 2.44799054373522 0.0221079683058909 0.24364348576286 GO:0008483 transaminase activity 5/1269 25/18639 0.2 2.93758865248227 0.0245919850687439 0.255691040434743 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/1269 25/18639 0.2 2.93758865248227 0.0245919850687439 0.255691040434743 GO:0016410 N-acyltransferase activity 12/1269 94/18639 0.127659574468085 1.87505658669081 0.0255534581330801 0.255691040434743 GO:0019783 ubiquitin-like protein peptidase activity 15/1269 127/18639 0.118110236220472 1.7347964483163 0.0258802464035688 0.255691040434743 GO:0034212 protein N-acetyltransferase activity 8/1269 53/18639 0.150943396226415 2.21704803960926 0.0259830328358948 0.255691040434743 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:0098505 G-rich strand telomeric DNA binding 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:1990757 ubiquitin ligase activator activity 3/1269 10/18639 0.3 4.4063829787234 0.0263105841420222 0.255691040434743 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 15/1269 128/18639 0.1171875 1.72124335106383 0.0275413694075982 0.265240755826329 GO:0001046 core promoter sequence-specific DNA binding 7/1269 44/18639 0.159090909090909 2.33671824629271 0.027935816585564 0.266532068604103 GO:0051287 NAD binding 8/1269 54/18639 0.148148148148148 2.17599159443131 0.0287465409768678 0.266532068604103 GO:0140463 chromatin-protein adaptor activity 8/1269 54/18639 0.148148148148148 2.17599159443131 0.0287465409768678 0.266532068604103 GO:0000175 3'-5'-RNA exonuclease activity 6/1269 35/18639 0.171428571428571 2.51793313069909 0.0291714237854818 0.266532068604103 GO:0010485 histone H4 acetyltransferase activity 6/1269 35/18639 0.171428571428571 2.51793313069909 0.0291714237854818 0.266532068604103 GO:0140566 histone reader activity 6/1269 35/18639 0.171428571428571 2.51793313069909 0.0291714237854818 0.266532068604103 GO:0046906 tetrapyrrole binding 17/1269 152/18639 0.111842105263158 1.6427304964539 0.0297552301060587 0.269562211723532 GO:0017075 syntaxin-1 binding 4/1269 18/18639 0.222222222222222 3.26398739164697 0.0303435115476879 0.270310115370653 GO:0098641 cadherin binding involved in cell-cell adhesion 4/1269 18/18639 0.222222222222222 3.26398739164697 0.0303435115476879 0.270310115370653 GO:0035091 phosphatidylinositol binding 28/1269 284/18639 0.0985915492957746 1.44810708220957 0.0312402380247104 0.27599846651583 GO:0020037 heme binding 16/1269 142/18639 0.112676056338028 1.65497952252522 0.0322721930077863 0.278434840042734 GO:0000993 RNA polymerase II complex binding 6/1269 36/18639 0.166666666666667 2.44799054373522 0.033058356510031 0.278434840042734 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/1269 36/18639 0.166666666666667 2.44799054373522 0.033058356510031 0.278434840042734 GO:0004364 glutathione transferase activity 5/1269 27/18639 0.185185185185185 2.71998949303914 0.0334155922890457 0.278434840042734 GO:0035255 ionotropic glutamate receptor binding 5/1269 27/18639 0.185185185185185 2.71998949303914 0.0334155922890457 0.278434840042734 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/1269 11/18639 0.272727272727273 4.00580270793037 0.0343811027929287 0.278434840042734 GO:0005536 D-glucose binding 3/1269 11/18639 0.272727272727273 4.00580270793037 0.0343811027929287 0.278434840042734 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/1269 11/18639 0.272727272727273 4.00580270793037 0.0343811027929287 0.278434840042734 GO:0043522 leucine zipper domain binding 3/1269 11/18639 0.272727272727273 4.00580270793037 0.0343811027929287 0.278434840042734 GO:0070990 snRNP binding 3/1269 11/18639 0.272727272727273 4.00580270793037 0.0343811027929287 0.278434840042734 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/1269 11/18639 0.272727272727273 4.00580270793037 0.0343811027929287 0.278434840042734 GO:0004540 RNA nuclease activity 14/1269 121/18639 0.115702479338843 1.69943145184925 0.0356814244698373 0.286792802693655 GO:0008301 DNA binding, bending 4/1269 19/18639 0.210526315789474 3.09219858156028 0.0364221840474663 0.290562050348817 GO:0019213 deacetylase activity 6/1269 37/18639 0.162162162162162 2.38182863714779 0.0372657578205594 0.295089593408726 GO:0061733 protein-lysine-acetyltransferase activity 7/1269 47/18639 0.148936170212766 2.18756601780595 0.0384953257422361 0.302584582488606 GO:0005525 GTP binding 35/1269 378/18639 0.0925925925925926 1.35999474651957 0.0397760756556781 0.310369524641751 GO:0000287 magnesium ion binding 23/1269 230/18639 0.1 1.46879432624113 0.0414227512967203 0.320876240117348 GO:0042162 telomeric DNA binding 6/1269 38/18639 0.157894736842105 2.31914893617021 0.0418002649618621 0.321471102476479 GO:0140693 molecular condensate scaffold activity 7/1269 48/18639 0.145833333333333 2.14199172576832 0.0425246543208146 0.32195562629082 GO:0016801 hydrolase activity, acting on ether bonds 3/1269 12/18639 0.25 3.67198581560284 0.0435746930452814 0.32195562629082 GO:0016803 ether hydrolase activity 3/1269 12/18639 0.25 3.67198581560284 0.0435746930452814 0.32195562629082 GO:0043047 single-stranded telomeric DNA binding 3/1269 12/18639 0.25 3.67198581560284 0.0435746930452814 0.32195562629082 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/1269 12/18639 0.25 3.67198581560284 0.0435746930452814 0.32195562629082 GO:0008080 N-acetyltransferase activity 9/1269 69/18639 0.130434782608696 1.91581868640148 0.0436703141367343 0.32195562629082 GO:0005543 phospholipid binding 44/1269 497/18639 0.0885311871227364 1.30034105341267 0.044507451459129 0.325879901437047 GO:0031593 polyubiquitin modification-dependent protein binding 8/1269 59/18639 0.135593220338983 1.99158552710662 0.0456070645185468 0.331659537213106 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/1269 39/18639 0.153846153846154 2.25968357883252 0.046667277362636 0.337076483112554 GO:0004518 nuclease activity 21/1269 209/18639 0.100478468899522 1.47582205029014 0.0475503484652381 0.341062013557197 GO:0031267 small GTPase binding 27/1269 283/18639 0.0954063604240283 1.40132320878129 0.0478571581230865 0.341062013557197 GO:0101005 deubiquitinase activity 13/1269 115/18639 0.11304347826087 1.66037619488128 0.0490192844987413 0.347030563769235 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/1269 60/18639 0.133333333333333 1.95839243498818 0.04961914396776 0.34896621645747 GO:0042393 histone binding 24/1269 247/18639 0.097165991902834 1.42716857610475 0.0500461166844458 0.349668619187403 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 8/1269 61/18639 0.131147540983607 1.92628764097198 0.0538528461635728 0.362810063358326 GO:0004535 poly(A)-specific ribonuclease activity 3/1269 13/18639 0.230769230769231 3.38952536824877 0.0538571810704768 0.362810063358326 GO:0019855 calcium channel inhibitor activity 3/1269 13/18639 0.230769230769231 3.38952536824877 0.0538571810704768 0.362810063358326 GO:0097157 pre-mRNA intronic binding 3/1269 13/18639 0.230769230769231 3.38952536824877 0.0538571810704768 0.362810063358326 GO:0004407 histone deacetylase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0008649 rRNA methyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0032931 histone H3K56 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0033558 protein lysine deacetylase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0043992 histone H3K9 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0043993 histone H3K18 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0043994 histone H3K23 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0043999 histone H2AK5 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0044012 histone H2AK9 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0044014 histone H2BK5 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0044015 histone H2BK12 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0044016 histone H3K4 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0044017 histone H3K27 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0044018 histone H3K36 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0140908 histone H3K122 acetyltransferase activity 4/1269 22/18639 0.181818181818182 2.67053513862025 0.0585500647869421 0.362810063358326 GO:0004527 exonuclease activity 10/1269 84/18639 0.119047619047619 1.74856467409659 0.0587148184854916 0.362810063358326 GO:0016407 acetyltransferase activity 11/1269 96/18639 0.114583333333333 1.68299349881797 0.0614806302984355 0.377717205684067 GO:0030515 snoRNA binding 5/1269 32/18639 0.15625 2.29499113475177 0.0631763998450413 0.378713344918385 GO:0051059 NF-kappaB binding 5/1269 32/18639 0.15625 2.29499113475177 0.0631763998450413 0.378713344918385 GO:0003684 damaged DNA binding 9/1269 74/18639 0.121621621621622 1.78637147786084 0.0632874637816494 0.378713344918385 GO:0043175 RNA polymerase core enzyme binding 6/1269 42/18639 0.142857142857143 2.09827760891591 0.0632984999296216 0.378713344918385 GO:0004843 cysteine-type deubiquitinase activity 12/1269 108/18639 0.111111111111111 1.63199369582348 0.0634141148179522 0.378713344918385 GO:0070742 C2H2 zinc finger domain binding 3/1269 14/18639 0.214285714285714 3.14741641337386 0.0651832448206895 0.384977285708934 GO:0098847 sequence-specific single stranded DNA binding 3/1269 14/18639 0.214285714285714 3.14741641337386 0.0651832448206895 0.384977285708934 GO:0016860 intramolecular oxidoreductase activity 7/1269 53/18639 0.132075471698113 1.9399170346581 0.0666823690546931 0.388352625041012 GO:0004602 glutathione peroxidase activity 4/1269 23/18639 0.173913043478261 2.55442491520197 0.0672078911436737 0.388352625041012 GO:0005158 insulin receptor binding 4/1269 23/18639 0.173913043478261 2.55442491520197 0.0672078911436737 0.388352625041012 GO:0140102 catalytic activity, acting on a rRNA 4/1269 23/18639 0.173913043478261 2.55442491520197 0.0672078911436737 0.388352625041012 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/1269 43/18639 0.13953488372093 2.04948045522019 0.0695244097334327 0.397441679171334 GO:0008200 ion channel inhibitor activity 6/1269 43/18639 0.13953488372093 2.04948045522019 0.0695244097334327 0.397441679171334 GO:0140416 transcription regulator inhibitor activity 5/1269 33/18639 0.151515151515152 2.2254459488502 0.0704710422562519 0.400710341340071 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 13/1269 122/18639 0.10655737704918 1.56510870828973 0.0718065503500709 0.406108940348373 GO:0003925 G protein activity 7/1269 54/18639 0.12962962962963 1.9039926451274 0.0723323860024544 0.406108940348373 GO:0160215 deacylase activity 8/1269 65/18639 0.123076923076923 1.80774686306601 0.073047609405691 0.406108940348373 GO:0001223 transcription coactivator binding 6/1269 44/18639 0.136363636363636 2.00290135396518 0.0760910297041486 0.406108940348373 GO:0016248 channel inhibitor activity 6/1269 44/18639 0.136363636363636 2.00290135396518 0.0760910297041486 0.406108940348373 GO:0019001 guanyl nucleotide binding 35/1269 400/18639 0.0875 1.28519503546099 0.0761200084950093 0.406108940348373 GO:0032561 guanyl ribonucleotide binding 35/1269 400/18639 0.0875 1.28519503546099 0.0761200084950093 0.406108940348373 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/1269 24/18639 0.166666666666667 2.44799054373522 0.0764878243668686 0.406108940348373 GO:0005540 hyaluronic acid binding 4/1269 24/18639 0.166666666666667 2.44799054373522 0.0764878243668686 0.406108940348373 GO:0043998 histone H2A acetyltransferase activity 4/1269 24/18639 0.166666666666667 2.44799054373522 0.0764878243668686 0.406108940348373 GO:0050699 WW domain binding 4/1269 24/18639 0.166666666666667 2.44799054373522 0.0764878243668686 0.406108940348373 GO:0070840 dynein complex binding 4/1269 24/18639 0.166666666666667 2.44799054373522 0.0764878243668686 0.406108940348373 GO:0051540 metal cluster binding 9/1269 77/18639 0.116883116883117 1.71677258911301 0.0773708838723078 0.406108940348373 GO:0016846 carbon-sulfur lyase activity 3/1269 15/18639 0.2 2.93758865248227 0.0774988062030572 0.406108940348373 GO:0120283 protein serine/threonine kinase binding 3/1269 15/18639 0.2 2.93758865248227 0.0774988062030572 0.406108940348373 GO:0140776 protein-containing complex destabilizing activity 3/1269 15/18639 0.2 2.93758865248227 0.0774988062030572 0.406108940348373 GO:0098632 cell-cell adhesion mediator activity 7/1269 55/18639 0.127272727272727 1.86937459703417 0.0782570375512477 0.408081820206262 GO:0141110 transporter inhibitor activity 6/1269 45/18639 0.133333333333333 1.95839243498818 0.0829963280992616 0.430694537563644 GO:0030170 pyridoxal phosphate binding 7/1269 56/18639 0.125 1.83599290780142 0.0844555611627931 0.436149733734424 GO:0005154 epidermal growth factor receptor binding 5/1269 35/18639 0.142857142857143 2.09827760891591 0.0863806772724381 0.441822698584863 GO:0061631 ubiquitin conjugating enzyme activity 5/1269 35/18639 0.142857142857143 2.09827760891591 0.0863806772724381 0.441822698584863 GO:0004708 MAP kinase kinase activity 3/1269 16/18639 0.1875 2.75398936170213 0.0907431010629861 0.453642254147277 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/1269 16/18639 0.1875 2.75398936170213 0.0907431010629861 0.453642254147277 GO:0017070 U6 snRNA binding 3/1269 16/18639 0.1875 2.75398936170213 0.0907431010629861 0.453642254147277 GO:0022858 alanine transmembrane transporter activity 3/1269 16/18639 0.1875 2.75398936170213 0.0907431010629861 0.453642254147277 GO:0070279 vitamin B6 binding 7/1269 57/18639 0.12280701754386 1.80378250591017 0.0909264422246587 0.453642254147277 GO:0140767 enzyme-substrate adaptor activity 14/1269 139/18639 0.100719424460432 1.47936119189755 0.0912376844168986 0.453642254147277 GO:0000049 tRNA binding 9/1269 80/18639 0.1125 1.65239361702128 0.0932209790526339 0.461357530589193 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/1269 36/18639 0.138888888888889 2.03999211977935 0.0949810515889555 0.463628968715039 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/1269 36/18639 0.138888888888889 2.03999211977935 0.0949810515889555 0.463628968715039 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/1269 36/18639 0.138888888888889 2.03999211977935 0.0949810515889555 0.463628968715039 GO:0031490 chromatin DNA binding 13/1269 128/18639 0.1015625 1.49174423758865 0.0960831387315943 0.46687670592761 GO:0008157 protein phosphatase 1 binding 4/1269 26/18639 0.153846153846154 2.25968357883252 0.0968422307271493 0.468190504450475 GO:0003924 GTPase activity 29/1269 331/18639 0.0876132930513595 1.28685907737139 0.0976662877732661 0.468190504450475 GO:0008408 3'-5' exonuclease activity 7/1269 58/18639 0.120689655172414 1.7726828075324 0.0976674298339158 0.468190504450475 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 21/1269 229/18639 0.091703056768559 1.34692929480628 0.100984537269849 0.480472502542562 GO:0019208 phosphatase regulator activity 12/1269 117/18639 0.102564102564103 1.50645571922168 0.101128450020651 0.480472502542562 GO:0070063 RNA polymerase binding 7/1269 59/18639 0.11864406779661 1.7426373362183 0.104675555934062 0.489180230435809 GO:0004549 tRNA-specific ribonuclease activity 3/1269 17/18639 0.176470588235294 2.59198998748436 0.104850462981584 0.489180230435809 GO:0016018 cyclosporin A binding 3/1269 17/18639 0.176470588235294 2.59198998748436 0.104850462981584 0.489180230435809 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 6/1269 48/18639 0.125 1.83599290780142 0.105706859897729 0.489180230435809 GO:0032266 phosphatidylinositol-3-phosphate binding 6/1269 48/18639 0.125 1.83599290780142 0.105706859897729 0.489180230435809 GO:0036121 double-stranded DNA helicase activity 6/1269 48/18639 0.125 1.83599290780142 0.105706859897729 0.489180230435809 GO:0001671 ATPase activator activity 4/1269 27/18639 0.148148148148148 2.17599159443131 0.107872950455515 0.497052517400628 GO:0140299 molecular sensor activity 8/1269 71/18639 0.112676056338028 1.65497952252522 0.108688322900888 0.498660159575317 GO:0019888 protein phosphatase regulator activity 11/1269 107/18639 0.102803738317757 1.509975475575 0.111670251903164 0.510151706343941 GO:0060590 ATPase regulator activity 6/1269 49/18639 0.122448979591837 1.79852366478506 0.113924048696786 0.516458479746203 GO:0004857 enzyme inhibitor activity 35/1269 416/18639 0.0841346153846154 1.23576445717403 0.1140170263986 0.516458479746203 GO:0051117 ATPase binding 9/1269 84/18639 0.107142857142857 1.57370820668693 0.117081905516047 0.526809593184691 GO:0019789 SUMO transferase activity 4/1269 28/18639 0.142857142857143 2.09827760891591 0.119439070808995 0.526809593184691 GO:0036408 histone H3K14 acetyltransferase activity 4/1269 28/18639 0.142857142857143 2.09827760891591 0.119439070808995 0.526809593184691 GO:0046875 ephrin receptor binding 4/1269 28/18639 0.142857142857143 2.09827760891591 0.119439070808995 0.526809593184691 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/1269 28/18639 0.142857142857143 2.09827760891591 0.119439070808995 0.526809593184691 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1269 18/18639 0.166666666666667 2.44799054373522 0.119751853268363 0.526809593184691 GO:0031690 adrenergic receptor binding 3/1269 18/18639 0.166666666666667 2.44799054373522 0.119751853268363 0.526809593184691 GO:0043539 protein serine/threonine kinase activator activity 8/1269 73/18639 0.10958904109589 1.6096376177985 0.122361066636929 0.536081886208514 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/1269 39/18639 0.128205128205128 1.8830696490271 0.123240163757289 0.537729530843027 GO:0051087 protein-folding chaperone binding 13/1269 134/18639 0.0970149253731343 1.42494971948767 0.124826449424461 0.542436887946135 GO:0051020 GTPase binding 27/1269 315/18639 0.0857142857142857 1.25896656534954 0.128572660647945 0.549561999354933 GO:0030544 Hsp70 protein binding 6/1269 51/18639 0.117647058823529 1.72799332498957 0.131286339667913 0.549561999354933 GO:0010484 histone H3 acetyltransferase activity 4/1269 29/18639 0.137931034482759 2.02592320860846 0.131512631310291 0.549561999354933 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/1269 40/18639 0.125 1.83599290780142 0.133435767125474 0.549561999354933 GO:0030331 nuclear estrogen receptor binding 5/1269 40/18639 0.125 1.83599290780142 0.133435767125474 0.549561999354933 GO:1902936 phosphatidylinositol bisphosphate binding 11/1269 111/18639 0.0990990990990991 1.45556194492365 0.134447942955579 0.549561999354933 GO:0015245 fatty acid transmembrane transporter activity 3/1269 19/18639 0.157894736842105 2.31914893617021 0.135376166247281 0.549561999354933 GO:0120227 acyl-CoA binding 3/1269 19/18639 0.157894736842105 2.31914893617021 0.135376166247281 0.549561999354933 GO:0019003 GDP binding 8/1269 75/18639 0.106666666666667 1.56671394799054 0.136892869434398 0.549561999354933 GO:0005080 protein kinase C binding 6/1269 52/18639 0.115384615384615 1.69476268412439 0.140414081577755 0.549561999354933 GO:0019842 vitamin binding 14/1269 150/18639 0.0933333333333333 1.37087470449173 0.14292473943916 0.549561999354933 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/1269 41/18639 0.121951219512195 1.79121259297699 0.143994326688861 0.549561999354933 GO:0042169 SH2 domain binding 5/1269 41/18639 0.121951219512195 1.79121259297699 0.143994326688861 0.549561999354933 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/1269 41/18639 0.121951219512195 1.79121259297699 0.143994326688861 0.549561999354933 GO:0001968 fibronectin binding 4/1269 30/18639 0.133333333333333 1.95839243498818 0.144063909159162 0.549561999354933 GO:0008187 poly-pyrimidine tract binding 4/1269 30/18639 0.133333333333333 1.95839243498818 0.144063909159162 0.549561999354933 GO:0043995 histone H4K5 acetyltransferase activity 4/1269 30/18639 0.133333333333333 1.95839243498818 0.144063909159162 0.549561999354933 GO:0043996 histone H4K8 acetyltransferase activity 4/1269 30/18639 0.133333333333333 1.95839243498818 0.144063909159162 0.549561999354933 GO:0043997 histone H4K12 acetyltransferase activity 4/1269 30/18639 0.133333333333333 1.95839243498818 0.144063909159162 0.549561999354933 GO:0051721 protein phosphatase 2A binding 4/1269 30/18639 0.133333333333333 1.95839243498818 0.144063909159162 0.549561999354933 GO:0017022 myosin binding 8/1269 76/18639 0.105263157894737 1.54609929078014 0.144470792277005 0.549561999354933 GO:0051536 iron-sulfur cluster binding 8/1269 76/18639 0.105263157894737 1.54609929078014 0.144470792277005 0.549561999354933 GO:0098631 cell adhesion mediator activity 8/1269 76/18639 0.105263157894737 1.54609929078014 0.144470792277005 0.549561999354933 GO:0001094 TFIID-class transcription factor complex binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0008140 cAMP response element binding protein binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0019911 structural constituent of myelin sheath 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0030957 Tat protein binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0032356 oxidized DNA binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0033204 ribonuclease P RNA binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0042975 peroxisome proliferator activated receptor binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0050815 phosphoserine residue binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0097177 mitochondrial ribosome binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0099122 RNA polymerase II C-terminal domain binding 2/1269 10/18639 0.2 2.93758865248227 0.144973324432265 0.549561999354933 GO:0019902 phosphatase binding 17/1269 190/18639 0.0894736842105263 1.31418439716312 0.151055561282636 0.570595035375047 GO:0030742 GTP-dependent protein binding 3/1269 20/18639 0.15 2.2031914893617 0.151651335961335 0.570828444164321 GO:0008307 structural constituent of muscle 5/1269 42/18639 0.119047619047619 1.74856467409659 0.154899168142812 0.574955592863424 GO:0016859 cis-trans isomerase activity 5/1269 42/18639 0.119047619047619 1.74856467409659 0.154899168142812 0.574955592863424 GO:0031492 nucleosomal DNA binding 5/1269 42/18639 0.119047619047619 1.74856467409659 0.154899168142812 0.574955592863424 GO:0042056 chemoattractant activity 5/1269 42/18639 0.119047619047619 1.74856467409659 0.154899168142812 0.574955592863424 GO:0004519 endonuclease activity 12/1269 127/18639 0.094488188976378 1.38783715865304 0.155886038211943 0.57661652196736 GO:0050661 NADP binding 6/1269 54/18639 0.111111111111111 1.63199369582348 0.159513422450852 0.587999477930899 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/1269 21/18639 0.142857142857143 2.09827760891591 0.168505267730435 0.599009143320569 GO:0019200 carbohydrate kinase activity 3/1269 21/18639 0.142857142857143 2.09827760891591 0.168505267730435 0.599009143320569 GO:0051010 microtubule plus-end binding 3/1269 21/18639 0.142857142857143 2.09827760891591 0.168505267730435 0.599009143320569 GO:0140312 cargo adaptor activity 3/1269 21/18639 0.142857142857143 2.09827760891591 0.168505267730435 0.599009143320569 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0010854 adenylate cyclase regulator activity 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0047676 arachidonate-CoA ligase activity 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0140031 phosphorylation-dependent protein binding 2/1269 11/18639 0.181818181818182 2.67053513862025 0.169549373685451 0.599009143320569 GO:0008173 RNA methyltransferase activity 7/1269 67/18639 0.104477611940299 1.53456123637133 0.169784630894417 0.599009143320569 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1269 67/18639 0.104477611940299 1.53456123637133 0.169784630894417 0.599009143320569 GO:0070717 poly-purine tract binding 4/1269 32/18639 0.125 1.83599290780142 0.170473958220849 0.599462701770025 GO:0016790 thiolester hydrolase activity 5/1269 44/18639 0.113636363636364 1.66908446163765 0.177676491458203 0.620910662617211 GO:0032934 sterol binding 7/1269 68/18639 0.102941176470588 1.51199415936587 0.178958022037073 0.620910662617211 GO:0046982 protein heterodimerization activity 30/1269 369/18639 0.0813008130081301 1.19414172865133 0.178958749739617 0.620910662617211 GO:0019903 protein phosphatase binding 13/1269 144/18639 0.0902777777777778 1.32599487785658 0.182272721687899 0.620910662617211 GO:0001618 virus receptor activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0140791 histone H2AXS140 phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1269 81/18639 0.0987654320987654 1.45066106295421 0.18527833272348 0.620910662617211 GO:0031683 G-protein beta/gamma-subunit complex binding 3/1269 22/18639 0.136363636363636 2.00290135396518 0.185866615563618 0.620910662617211 GO:0046972 histone H4K16 acetyltransferase activity 3/1269 22/18639 0.136363636363636 2.00290135396518 0.185866615563618 0.620910662617211 GO:0140784 metal ion sensor activity 3/1269 22/18639 0.136363636363636 2.00290135396518 0.185866615563618 0.620910662617211 GO:0008009 chemokine activity 5/1269 45/18639 0.111111111111111 1.63199369582348 0.189511511878071 0.629154677632477 GO:0051539 4 iron, 4 sulfur cluster binding 5/1269 45/18639 0.111111111111111 1.63199369582348 0.189511511878071 0.629154677632477 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1269 82/18639 0.0975609756097561 1.43297007438159 0.193982393535294 0.630853536941257 GO:0033549 MAP kinase phosphatase activity 8/1269 82/18639 0.0975609756097561 1.43297007438159 0.193982393535294 0.630853536941257 GO:0140272 exogenous protein binding 8/1269 82/18639 0.0975609756097561 1.43297007438159 0.193982393535294 0.630853536941257 GO:0004526 ribonuclease P activity 2/1269 12/18639 0.166666666666667 2.44799054373522 0.194744309813485 0.630853536941257 GO:0005247 voltage-gated chloride channel activity 2/1269 12/18639 0.166666666666667 2.44799054373522 0.194744309813485 0.630853536941257 GO:0016423 tRNA (guanine) methyltransferase activity 2/1269 12/18639 0.166666666666667 2.44799054373522 0.194744309813485 0.630853536941257 GO:0045295 gamma-catenin binding 2/1269 12/18639 0.166666666666667 2.44799054373522 0.194744309813485 0.630853536941257 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1269 12/18639 0.166666666666667 2.44799054373522 0.194744309813485 0.630853536941257 GO:0097110 scaffold protein binding 7/1269 70/18639 0.1 1.46879432624113 0.19790799532597 0.636933748445794 GO:0015035 protein-disulfide reductase activity 4/1269 34/18639 0.117647058823529 1.72799332498957 0.19840873548405 0.636933748445794 GO:0030332 cyclin binding 4/1269 34/18639 0.117647058823529 1.72799332498957 0.19840873548405 0.636933748445794 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/1269 46/18639 0.108695652173913 1.59651557200123 0.201618145639334 0.645298795474394 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1269 83/18639 0.0963855421686747 1.41570537469025 0.202852164680554 0.647310340428394 GO:0017134 fibroblast growth factor binding 3/1269 23/18639 0.130434782608696 1.91581868640148 0.20366542422661 0.647971245530493 GO:0008234 cysteine-type peptidase activity 16/1269 187/18639 0.0855614973262032 1.25672241817423 0.205249346627165 0.651072853247594 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/1269 122/18639 0.0901639344262295 1.32432275316824 0.20850412489644 0.659440560693179 GO:0017018 myosin phosphatase activity 8/1269 84/18639 0.0952380952380952 1.39885173927727 0.211880613013659 0.665437858333158 GO:0061749 forked DNA-dependent helicase activity 5/1269 47/18639 0.106382978723404 1.56254715557568 0.213976367239181 0.665437858333158 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/1269 47/18639 0.106382978723404 1.56254715557568 0.213976367239181 0.665437858333158 GO:0005172 vascular endothelial growth factor receptor binding 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0005542 folic acid binding 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0008253 5'-nucleotidase activity 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0009982 pseudouridine synthase activity 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0035325 Toll-like receptor binding 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0045159 myosin II binding 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0046974 histone H3K9 methyltransferase activity 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0071837 HMG box domain binding 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0140666 annealing activity 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0140852 histone ubiquitin ligase activity 2/1269 13/18639 0.153846153846154 2.25968357883252 0.220360151403123 0.665437858333158 GO:0070300 phosphatidic acid binding 3/1269 24/18639 0.125 1.83599290780142 0.221833652778001 0.667434342449926 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1269 60/18639 0.1 1.46879432624113 0.222726012593903 0.667434342449926 GO:0008170 N-methyltransferase activity 9/1269 98/18639 0.0918367346938776 1.3488927485888 0.222894350097871 0.667434342449926 GO:0009378 four-way junction helicase activity 5/1269 48/18639 0.104166666666667 1.52999408983452 0.226565844837024 0.674648713456209 GO:0043138 3'-5' DNA helicase activity 5/1269 48/18639 0.104166666666667 1.52999408983452 0.226565844837024 0.674648713456209 GO:0004521 RNA endonuclease activity 7/1269 73/18639 0.0958904109589041 1.40843291557369 0.227702324919705 0.676149403719903 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/1269 86/18639 0.0930232558139535 1.36632030348013 0.230384282700662 0.682218277581739 GO:0048029 monosaccharide binding 7/1269 74/18639 0.0945945945945946 1.38940003833621 0.237960022695994 0.70187617655585 GO:0035254 glutamate receptor binding 5/1269 49/18639 0.102040816326531 1.49876972065422 0.23936604894387 0.70187617655585 GO:0017025 TBP-class protein binding 3/1269 25/18639 0.12 1.76255319148936 0.240305594592555 0.70187617655585 GO:0017056 structural constituent of nuclear pore 3/1269 25/18639 0.12 1.76255319148936 0.240305594592555 0.70187617655585 GO:0019211 phosphatase activator activity 3/1269 25/18639 0.12 1.76255319148936 0.240305594592555 0.70187617655585 GO:0042805 actinin binding 4/1269 37/18639 0.108108108108108 1.58788575809852 0.24258118402454 0.706592059188648 GO:0005545 1-phosphatidylinositol binding 2/1269 14/18639 0.142857142857143 2.09827760891591 0.246222969166861 0.707560091503695 GO:0008474 palmitoyl-(protein) hydrolase activity 2/1269 14/18639 0.142857142857143 2.09827760891591 0.246222969166861 0.707560091503695 GO:0016530 metallochaperone activity 2/1269 14/18639 0.142857142857143 2.09827760891591 0.246222969166861 0.707560091503695 GO:0061665 SUMO ligase activity 2/1269 14/18639 0.142857142857143 2.09827760891591 0.246222969166861 0.707560091503695 GO:0098599 palmitoyl hydrolase activity 2/1269 14/18639 0.142857142857143 2.09827760891591 0.246222969166861 0.707560091503695 GO:0042826 histone deacetylase binding 11/1269 127/18639 0.0866141732283465 1.27218406209862 0.246923092801623 0.707669668109745 GO:0050681 nuclear androgen receptor binding 3/1269 26/18639 0.115384615384615 1.69476268412439 0.259018207270651 0.738374569526204 GO:0070006 metalloaminopeptidase activity 3/1269 26/18639 0.115384615384615 1.69476268412439 0.259018207270651 0.738374569526204 GO:0004722 protein serine/threonine phosphatase activity 9/1269 103/18639 0.087378640776699 1.28341251807478 0.267472436027595 0.759689267509237 GO:0004467 long-chain fatty acid-CoA ligase activity 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0005041 low-density lipoprotein particle receptor activity 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0005523 tropomyosin binding 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0008252 nucleotidase activity 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0033130 acetylcholine receptor binding 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0050780 dopamine receptor binding 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0061578 K63-linked deubiquitinase activity 2/1269 15/18639 0.133333333333333 1.95839243498818 0.272180532699755 0.759689267509237 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1269 27/18639 0.111111111111111 1.63199369582348 0.277911364372544 0.769632511224979 GO:0005385 zinc ion transmembrane transporter activity 3/1269 27/18639 0.111111111111111 1.63199369582348 0.277911364372544 0.769632511224979 GO:0030159 signaling receptor complex adaptor activity 5/1269 52/18639 0.0961538461538462 1.41230223677032 0.278824868744414 0.769632511224979 GO:0072341 modified amino acid binding 8/1269 91/18639 0.0879120879120879 1.29124775933287 0.27888958368224 0.769632511224979 GO:0031072 heat shock protein binding 11/1269 131/18639 0.083969465648855 1.23333874722538 0.279342763662574 0.769632511224979 GO:0004842 ubiquitin-protein transferase activity 34/1269 449/18639 0.0757238307349666 1.11222732944763 0.283082569321171 0.777931276617818 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 11/1269 132/18639 0.0833333333333333 1.22399527186761 0.287645264288901 0.787230705956571 GO:0004177 aminopeptidase activity 4/1269 40/18639 0.1 1.46879432624113 0.288675806113167 0.787230705956571 GO:0015036 disulfide oxidoreductase activity 4/1269 40/18639 0.1 1.46879432624113 0.288675806113167 0.787230705956571 GO:0019787 ubiquitin-like protein transferase activity 36/1269 479/18639 0.0751565762004175 1.10389552702883 0.291602834081627 0.788784844629409 GO:0004864 protein phosphatase inhibitor activity 5/1269 53/18639 0.0943396226415094 1.38565502475579 0.292262184173702 0.788784844629409 GO:0005544 calcium-dependent phospholipid binding 5/1269 53/18639 0.0943396226415094 1.38565502475579 0.292262184173702 0.788784844629409 GO:0016251 RNA polymerase II general transcription initiation factor activity 5/1269 53/18639 0.0943396226415094 1.38565502475579 0.292262184173702 0.788784844629409 GO:0016741 transferase activity, transferring one-carbon groups 17/1269 215/18639 0.0790697674418605 1.16137225795811 0.296175667470053 0.788784844629409 GO:0051537 2 iron, 2 sulfur cluster binding 3/1269 28/18639 0.107142857142857 1.57370820668693 0.296928039600169 0.788784844629409 GO:0000062 fatty-acyl-CoA binding 2/1269 16/18639 0.125 1.83599290780142 0.298100165790721 0.788784844629409 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/1269 16/18639 0.125 1.83599290780142 0.298100165790721 0.788784844629409 GO:0005521 lamin binding 2/1269 16/18639 0.125 1.83599290780142 0.298100165790721 0.788784844629409 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1269 16/18639 0.125 1.83599290780142 0.298100165790721 0.788784844629409 GO:0043023 ribosomal large subunit binding 2/1269 16/18639 0.125 1.83599290780142 0.298100165790721 0.788784844629409 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1269 16/18639 0.125 1.83599290780142 0.298100165790721 0.788784844629409 GO:0051219 phosphoprotein binding 8/1269 93/18639 0.0860215053763441 1.26347899031495 0.299021454002703 0.78926897365158 GO:0001530 lipopolysaccharide binding 4/1269 41/18639 0.0975609756097561 1.43297007438159 0.304317047132011 0.79928783995865 GO:0015485 cholesterol binding 5/1269 54/18639 0.0925925925925926 1.35999474651957 0.305807976186238 0.79928783995865 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/1269 54/18639 0.0925925925925926 1.35999474651957 0.305807976186238 0.79928783995865 GO:0017069 snRNA binding 5/1269 54/18639 0.0925925925925926 1.35999474651957 0.305807976186238 0.79928783995865 GO:0008168 methyltransferase activity 16/1269 204/18639 0.0784313725490196 1.15199554999305 0.315090738920898 0.808910283965757 GO:0003777 microtubule motor activity 6/1269 68/18639 0.0882352941176471 1.29599499374218 0.316842621628408 0.808910283965757 GO:0030145 manganese ion binding 6/1269 68/18639 0.0882352941176471 1.29599499374218 0.316842621628408 0.808910283965757 GO:0140223 general transcription initiation factor activity 6/1269 68/18639 0.0882352941176471 1.29599499374218 0.316842621628408 0.808910283965757 GO:0061659 ubiquitin-like protein ligase activity 28/1269 372/18639 0.0752688172043011 1.10554411652559 0.31754896144126 0.808910283965757 GO:0140313 molecular sequestering activity 5/1269 55/18639 0.0909090909090909 1.33526756931012 0.319442455418148 0.808910283965757 GO:0051879 Hsp90 protein binding 4/1269 42/18639 0.0952380952380952 1.39885173927727 0.320045244920348 0.808910283965757 GO:0004550 nucleoside diphosphate kinase activity 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0004659 prenyltransferase activity 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0017110 nucleoside diphosphate phosphatase activity 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0030169 low-density lipoprotein particle binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0030548 acetylcholine receptor regulator activity 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0031489 myosin V binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0032183 SUMO binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0032977 membrane insertase activity 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0036041 long-chain fatty acid binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0070403 NAD+ binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:1901567 fatty acid derivative binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:1990226 histone methyltransferase binding 2/1269 17/18639 0.117647058823529 1.72799332498957 0.32386679283194 0.808910283965757 GO:0019212 phosphatase inhibitor activity 5/1269 56/18639 0.0892857142857143 1.31142350557244 0.333146215891334 0.83014756360801 GO:0031624 ubiquitin conjugating enzyme binding 3/1269 30/18639 0.1 1.46879432624113 0.335120046609411 0.831026614147011 GO:0030165 PDZ domain binding 7/1269 83/18639 0.0843373493975904 1.23874220285397 0.335603263942925 0.831026614147011 GO:0048156 tau protein binding 4/1269 43/18639 0.0930232558139535 1.36632030348013 0.335831148093086 0.831026614147011 GO:0016504 peptidase activator activity 5/1269 57/18639 0.087719298245614 1.28841607565012 0.346900292143374 0.837418072503423 GO:0030295 protein kinase activator activity 11/1269 139/18639 0.079136690647482 1.16235522220521 0.347458292618645 0.837418072503423 GO:0000400 four-way junction DNA binding 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0003746 translation elongation factor activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0008308 voltage-gated monoatomic anion channel activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0008409 5'-3' exonuclease activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0015172 acidic amino acid transmembrane transporter activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0017128 phospholipid scramblase activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0030228 lipoprotein particle receptor activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0035615 clathrin adaptor activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0050811 GABA receptor binding 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0070064 proline-rich region binding 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0099602 neurotransmitter receptor regulator activity 2/1269 18/18639 0.111111111111111 1.63199369582348 0.349381160277387 0.837418072503423 GO:0019205 nucleobase-containing compound kinase activity 4/1269 44/18639 0.0909090909090909 1.33526756931012 0.351646613756574 0.840962483458116 GO:0016878 acid-thiol ligase activity 3/1269 31/18639 0.0967741935483871 1.42141386410432 0.354197719807861 0.841416361054675 GO:0047499 calcium-independent phospholipase A2 activity 3/1269 31/18639 0.0967741935483871 1.42141386410432 0.354197719807861 0.841416361054675 GO:0070273 phosphatidylinositol-4-phosphate binding 3/1269 31/18639 0.0967741935483871 1.42141386410432 0.354197719807861 0.841416361054675 GO:0005506 iron ion binding 12/1269 154/18639 0.0779220779220779 1.14451505940868 0.356954198738354 0.846084342464082 GO:0017116 single-stranded DNA helicase activity 5/1269 58/18639 0.0862068965517241 1.26620200538029 0.360686210220283 0.853038846737793 GO:0061630 ubiquitin protein ligase activity 26/1269 353/18639 0.0736543909348442 1.08183151507846 0.367149178239941 0.866407221939288 GO:0016755 aminoacyltransferase activity 36/1269 496/18639 0.0725806451612903 1.06606039807824 0.368877329378932 0.868552571514267 GO:0047498 calcium-dependent phospholipase A2 activity 3/1269 32/18639 0.09375 1.37699468085106 0.373203626178932 0.868552571514267 GO:0001786 phosphatidylserine binding 5/1269 59/18639 0.0847457627118644 1.24474095444164 0.37448603273272 0.868552571514267 GO:0008574 plus-end-directed microtubule motor activity 2/1269 19/18639 0.105263157894737 1.54609929078014 0.374558218398575 0.868552571514267 GO:0034987 immunoglobulin receptor binding 2/1269 19/18639 0.105263157894737 1.54609929078014 0.374558218398575 0.868552571514267 GO:0042834 peptidoglycan binding 2/1269 19/18639 0.105263157894737 1.54609929078014 0.374558218398575 0.868552571514267 GO:0050145 nucleoside monophosphate kinase activity 2/1269 19/18639 0.105263157894737 1.54609929078014 0.374558218398575 0.868552571514267 GO:0140036 ubiquitin-modified protein reader activity 2/1269 19/18639 0.105263157894737 1.54609929078014 0.374558218398575 0.868552571514267 GO:0003779 actin binding 32/1269 443/18639 0.072234762979684 1.06098010021933 0.389726389176098 0.900561874186839 GO:0003678 DNA helicase activity 6/1269 74/18639 0.0810810810810811 1.19091431857389 0.390889344829461 0.900561874186839 GO:0031491 nucleosome binding 6/1269 74/18639 0.0810810810810811 1.19091431857389 0.390889344829461 0.900561874186839 GO:0004197 cysteine-type endopeptidase activity 7/1269 88/18639 0.0795454545454545 1.16835912314636 0.392153892307588 0.900588859947985 GO:0019207 kinase regulator activity 21/1269 287/18639 0.0731707317073171 1.0747275557862 0.398227247394036 0.900588859947985 GO:0005085 guanyl-nucleotide exchange factor activity 17/1269 230/18639 0.0739130434782609 1.08563058896084 0.398743032934011 0.900588859947985 GO:0005504 fatty acid binding 4/1269 47/18639 0.0851063829787234 1.25003772446054 0.399006855380764 0.900588859947985 GO:0043495 protein-membrane adaptor activity 4/1269 47/18639 0.0851063829787234 1.25003772446054 0.399006855380764 0.900588859947985 GO:0010851 cyclase regulator activity 2/1269 20/18639 0.1 1.46879432624113 0.399325649780491 0.900588859947985 GO:0015095 magnesium ion transmembrane transporter activity 2/1269 20/18639 0.1 1.46879432624113 0.399325649780491 0.900588859947985 GO:0016004 phospholipase activator activity 2/1269 20/18639 0.1 1.46879432624113 0.399325649780491 0.900588859947985 GO:0031418 L-ascorbic acid binding 2/1269 20/18639 0.1 1.46879432624113 0.399325649780491 0.900588859947985 GO:0052745 inositol phosphate phosphatase activity 2/1269 20/18639 0.1 1.46879432624113 0.399325649780491 0.900588859947985 GO:0003725 double-stranded RNA binding 6/1269 75/18639 0.08 1.17503546099291 0.403282853566347 0.907598674657736 GO:0016831 carboxy-lyase activity 3/1269 34/18639 0.0882352941176471 1.29599499374218 0.410841291467033 0.920732370185028 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1269 34/18639 0.0882352941176471 1.29599499374218 0.410841291467033 0.920732370185028 GO:0015179 L-amino acid transmembrane transporter activity 5/1269 62/18639 0.0806451612903226 1.18451155342027 0.415798389655351 0.929892214522114 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0035613 RNA stem-loop binding 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0061891 calcium ion sensor activity 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0070182 DNA polymerase binding 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0072542 protein phosphatase activator activity 2/1269 21/18639 0.0952380952380952 1.39885173927727 0.42362253210155 0.933716467663005 GO:0019209 kinase activator activity 11/1269 148/18639 0.0743243243243243 1.09167145869274 0.426798814246227 0.938781753969582 GO:0004623 phospholipase A2 activity 3/1269 35/18639 0.0857142857142857 1.25896656534954 0.42940166546691 0.942567516189172 GO:0000149 SNARE binding 8/1269 106/18639 0.0754716981132075 1.10852401980463 0.434715413916654 0.950328788296326 GO:0008013 beta-catenin binding 8/1269 106/18639 0.0754716981132075 1.10852401980463 0.434715413916654 0.950328788296326 GO:0043178 alcohol binding 7/1269 92/18639 0.0760869565217391 1.11756090040086 0.437491199172383 0.952331639611936 GO:0051082 unfolded protein binding 9/1269 121/18639 0.0743801652892562 1.09249164761737 0.441854023228875 0.952331639611936 GO:0004536 DNA nuclease activity 5/1269 64/18639 0.078125 1.14749556737589 0.443107970030256 0.952331639611936 GO:0048020 CCR chemokine receptor binding 4/1269 50/18639 0.08 1.17503546099291 0.445737564246168 0.952331639611936 GO:0008970 phospholipase A1 activity 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0050321 tau-protein kinase activity 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0061133 endopeptidase activator activity 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0070034 telomerase RNA binding 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0140035 ubiquitin-like protein reader activity 2/1269 22/18639 0.0909090909090909 1.33526756931012 0.447398123755343 0.952331639611936 GO:0140789 histone phosphatase activity 10/1269 136/18639 0.0735294117647059 1.07999582811848 0.447976673641687 0.952331639611936 GO:0051213 dioxygenase activity 7/1269 93/18639 0.0752688172043011 1.10554411652559 0.448761992383869 0.952331639611936 GO:0051015 actin filament binding 15/1269 209/18639 0.0717703349282297 1.0541586073501 0.454784085840891 0.952331639611936 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 12/1269 167/18639 0.0718562874251497 1.05542107274812 0.466491122065767 0.952331639611936 GO:0005283 amino acid:sodium symporter activity 2/1269 23/18639 0.0869565217391304 1.27721245760099 0.470610761805698 0.952331639611936 GO:0008171 O-methyltransferase activity 2/1269 23/18639 0.0869565217391304 1.27721245760099 0.470610761805698 0.952331639611936 GO:0042171 lysophosphatidic acid acyltransferase activity 2/1269 23/18639 0.0869565217391304 1.27721245760099 0.470610761805698 0.952331639611936 GO:0071617 lysophospholipid acyltransferase activity 2/1269 23/18639 0.0869565217391304 1.27721245760099 0.470610761805698 0.952331639611936 GO:0008276 protein methyltransferase activity 7/1269 95/18639 0.0736842105263158 1.0822695035461 0.47116787317133 0.952331639611936 GO:0019887 protein kinase regulator activity 18/1269 255/18639 0.0705882352941176 1.03679599499374 0.472113068992709 0.952331639611936 GO:0061134 peptidase regulator activity 16/1269 226/18639 0.0707964601769911 1.03985439025921 0.473042641023139 0.952331639611936 GO:0030971 receptor tyrosine kinase binding 6/1269 81/18639 0.0740740740740741 1.08799579721566 0.476869605114442 0.952331639611936 GO:0042054 histone methyltransferase activity 5/1269 67/18639 0.0746268656716418 1.09611516883667 0.483436067951483 0.952331639611936 GO:0000146 microfilament motor activity 3/1269 38/18639 0.0789473684210526 1.15957446808511 0.483685139813457 0.952331639611936 GO:0005109 frizzled binding 3/1269 38/18639 0.0789473684210526 1.15957446808511 0.483685139813457 0.952331639611936 GO:0061135 endopeptidase regulator activity 13/1269 184/18639 0.0706521739130435 1.0377351218008 0.486472162873477 0.952331639611936 GO:0004622 lysophospholipase activity 2/1269 24/18639 0.0833333333333333 1.22399527186761 0.493226862626399 0.952331639611936 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1269 24/18639 0.0833333333333333 1.22399527186761 0.493226862626399 0.952331639611936 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1269 24/18639 0.0833333333333333 1.22399527186761 0.493226862626399 0.952331639611936 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1269 24/18639 0.0833333333333333 1.22399527186761 0.493226862626399 0.952331639611936 GO:0060229 lipase activator activity 2/1269 24/18639 0.0833333333333333 1.22399527186761 0.493226862626399 0.952331639611936 GO:0140612 DNA damage sensor activity 2/1269 24/18639 0.0833333333333333 1.22399527186761 0.493226862626399 0.952331639611936 GO:0016829 lyase activity 14/1269 200/18639 0.07 1.02815602836879 0.497110121615793 0.952331639611936 GO:0001540 amyloid-beta binding 6/1269 83/18639 0.072289156626506 1.06177903101769 0.50085177115112 0.952331639611936 GO:0000217 DNA secondary structure binding 3/1269 39/18639 0.0769230769230769 1.12984178941626 0.501229584613379 0.952331639611936 GO:0004090 carbonyl reductase (NADPH) activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0004935 adrenergic receptor activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0004955 prostaglandin receptor activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0005522 profilin binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0008190 eukaryotic initiation factor 4E binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0008519 ammonium channel activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0015187 glycine transmembrane transporter activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0031419 cobalamin binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0031434 mitogen-activated protein kinase kinase binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0035374 chondroitin sulfate binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0043295 glutathione binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0043422 protein kinase B binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0051880 G-quadruplex DNA binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0071723 lipopeptide binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0140940 histone H2A methyltransferase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0141109 transporter activator activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:1990259 histone H2AQ104 methyltransferase activity 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:1990763 arrestin family protein binding 1/1269 10/18639 0.1 1.46879432624113 0.506035801985576 0.952331639611936 GO:0015645 fatty acid ligase activity 2/1269 25/18639 0.08 1.17503546099291 0.515220016368471 0.952331639611936 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1269 25/18639 0.08 1.17503546099291 0.515220016368471 0.952331639611936 GO:0047617 fatty acyl-CoA hydrolase activity 2/1269 25/18639 0.08 1.17503546099291 0.515220016368471 0.952331639611936 GO:0120515 fatty acid-CoA ligase activity 2/1269 25/18639 0.08 1.17503546099291 0.515220016368471 0.952331639611936 GO:0033218 amide binding 17/1269 247/18639 0.0688259109311741 1.01091107474086 0.517816038105297 0.952331639611936 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/1269 40/18639 0.075 1.10159574468085 0.518463674762044 0.952331639611936 GO:0003730 mRNA 3'-UTR binding 18/1269 262/18639 0.0687022900763359 1.00909533863895 0.519432436015027 0.952331639611936 GO:0017124 SH3 domain binding 8/1269 115/18639 0.0695652173913043 1.02176996608079 0.52752827243299 0.952331639611936 GO:0004721 phosphoprotein phosphatase activity 12/1269 175/18639 0.0685714285714286 1.00717325227964 0.532799421923698 0.952331639611936 GO:0170055 lipid transmembrane transporter activity 4/1269 56/18639 0.0714285714285714 1.04913880445795 0.535195226951933 0.952331639611936 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/1269 41/18639 0.0731707317073171 1.0747275557862 0.535369987469678 0.952331639611936 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1269 41/18639 0.0731707317073171 1.0747275557862 0.535369987469678 0.952331639611936 GO:0017080 sodium channel regulator activity 3/1269 41/18639 0.0731707317073171 1.0747275557862 0.535369987469678 0.952331639611936 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0004529 DNA exonuclease activity 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0008143 poly(A) binding 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0008198 ferrous iron binding 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0016289 acyl-CoA hydrolase activity 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0034237 protein kinase A regulatory subunit binding 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0043548 phosphatidylinositol 3-kinase binding 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0050750 low-density lipoprotein particle receptor binding 2/1269 26/18639 0.0769230769230769 1.12984178941626 0.536570167126623 0.952331639611936 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0002162 dystroglycan binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0004954 prostanoid receptor activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0008199 ferric iron binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0008432 JUN kinase binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0016594 glycine binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0019107 myristoyltransferase activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0019206 nucleoside kinase activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0032794 GTPase activating protein binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0034511 U3 snoRNA binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0034713 type I transforming growth factor beta receptor binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0045294 alpha-catenin binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0048185 activin binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0048407 platelet-derived growth factor binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0050998 nitric-oxide synthase binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0140537 transcription regulator activator activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0180030 inositol phosphate kinase activity 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:1900750 oligopeptide binding 1/1269 11/18639 0.0909090909090909 1.33526756931012 0.539684444815589 0.952331639611936 GO:0004866 endopeptidase inhibitor activity 11/1269 161/18639 0.0683229813664596 1.00352407382935 0.540052087193545 0.952331639611936 GO:1990782 protein tyrosine kinase binding 8/1269 117/18639 0.0683760683760684 1.00430381281445 0.547447421820298 0.952331639611936 GO:0042379 chemokine receptor binding 5/1269 72/18639 0.0694444444444444 1.01999605988968 0.548145043284209 0.952331639611936 GO:0005516 calmodulin binding 14/1269 207/18639 0.0676328502415459 0.99338746702299 0.55010133300068 0.952331639611936 GO:0004520 DNA endonuclease activity 3/1269 42/18639 0.0714285714285714 1.04913880445795 0.551933429204242 0.952331639611936 GO:0035198 miRNA binding 3/1269 42/18639 0.0714285714285714 1.04913880445795 0.551933429204242 0.952331639611936 GO:0008266 poly(U) RNA binding 2/1269 27/18639 0.0740740740740741 1.08799579721566 0.55726287134695 0.952331639611936 GO:0008320 protein transmembrane transporter activity 2/1269 27/18639 0.0740740740740741 1.08799579721566 0.55726287134695 0.952331639611936 GO:0016405 CoA-ligase activity 2/1269 27/18639 0.0740740740740741 1.08799579721566 0.55726287134695 0.952331639611936 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1269 27/18639 0.0740740740740741 1.08799579721566 0.55726287134695 0.952331639611936 GO:0061980 regulatory RNA binding 4/1269 58/18639 0.0689655172413793 1.01296160430423 0.563385421369367 0.952331639611936 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1269 43/18639 0.0697674418604651 1.02474022761009 0.568141100287579 0.952331639611936 GO:0003720 telomerase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0003995 acyl-CoA dehydrogenase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0004032 aldose reductase (NADPH) activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0004859 phospholipase inhibitor activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0004875 complement receptor activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0005025 transforming growth factor beta receptor activity, type I 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0005026 transforming growth factor beta receptor activity, type II 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0005049 nuclear export signal receptor activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0005078 MAP-kinase scaffold activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0005095 GTPase inhibitor activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0005165 neurotrophin receptor binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0010853 cyclase activator activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0015132 prostaglandin transmembrane transporter activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0016361 activin receptor activity, type I 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0016362 activin receptor activity, type II 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0017002 activin receptor activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0017166 vinculin binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0031543 peptidyl-proline dioxygenase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0034452 dynactin binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0035197 siRNA binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0035251 UDP-glucosyltransferase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0035497 cAMP response element binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0036009 protein-glutamine N-methyltransferase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0042301 phosphate ion binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0097677 STAT family protein binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:1990459 transferrin receptor binding 1/1269 12/18639 0.0833333333333333 1.22399527186761 0.571042638906689 0.952331639611936 GO:0035064 methylated histone binding 5/1269 74/18639 0.0675675675675676 0.992428598811578 0.572919004402469 0.95397261013433 GO:0045309 protein phosphorylated amino acid binding 4/1269 59/18639 0.0677966101694915 0.995792763553312 0.577123558724759 0.954035616448699 GO:0016866 intramolecular transferase activity 2/1269 28/18639 0.0714285714285714 1.04913880445795 0.577288627635163 0.954035616448699 GO:0051019 mitogen-activated protein kinase binding 2/1269 28/18639 0.0714285714285714 1.04913880445795 0.577288627635163 0.954035616448699 GO:0051959 dynein light intermediate chain binding 2/1269 28/18639 0.0714285714285714 1.04913880445795 0.577288627635163 0.954035616448699 GO:0003954 NADH dehydrogenase activity 3/1269 44/18639 0.0681818181818182 1.00145067698259 0.583982160277652 0.954035616448699 GO:0044183 protein folding chaperone 5/1269 75/18639 0.0666666666666667 0.97919621749409 0.585035872319335 0.954035616448699 GO:0003785 actin monomer binding 2/1269 29/18639 0.0689655172413793 1.01296160430423 0.596642271692258 0.954035616448699 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1269 29/18639 0.0689655172413793 1.01296160430423 0.596642271692258 0.954035616448699 GO:0005416 amino acid:monoatomic cation symporter activity 2/1269 29/18639 0.0689655172413793 1.01296160430423 0.596642271692258 0.954035616448699 GO:0051861 glycolipid binding 2/1269 29/18639 0.0689655172413793 1.01296160430423 0.596642271692258 0.954035616448699 GO:0097472 cyclin-dependent protein kinase activity 2/1269 29/18639 0.0689655172413793 1.01296160430423 0.596642271692258 0.954035616448699 GO:0106222 lncRNA binding 2/1269 29/18639 0.0689655172413793 1.01296160430423 0.596642271692258 0.954035616448699 GO:0140034 methylation-dependent protein binding 5/1269 76/18639 0.0657894736842105 0.966312056737589 0.596963877850359 0.954035616448699 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/1269 45/18639 0.0666666666666667 0.97919621749409 0.599447695120597 0.954035616448699 GO:0046915 transition metal ion transmembrane transporter activity 3/1269 45/18639 0.0666666666666667 0.97919621749409 0.599447695120597 0.954035616448699 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0003964 RNA-directed DNA polymerase activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0031432 titin binding 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0031994 insulin-like growth factor I binding 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0032396 inhibitory MHC class I receptor activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0035673 oligopeptide transmembrane transporter activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0046975 histone H3K36 methyltransferase activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0051011 microtubule minus-end binding 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0061459 L-arginine transmembrane transporter activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0070123 transforming growth factor beta receptor activity, type III 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0070700 BMP receptor binding 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0071714 icosanoid transmembrane transporter activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:1901338 catecholamine binding 1/1269 13/18639 0.0769230769230769 1.12984178941626 0.600266179531986 0.954035616448699 GO:0052689 carboxylic ester hydrolase activity 6/1269 92/18639 0.0652173913043478 0.95790934320074 0.6030014142899 0.954035616448699 GO:0019905 syntaxin binding 4/1269 61/18639 0.0655737704918033 0.96314382048599 0.603844048705766 0.954035616448699 GO:0030414 peptidase inhibitor activity 11/1269 169/18639 0.0650887573964497 0.95601997565991 0.605747936401081 0.954035616448699 GO:0005496 steroid binding 7/1269 108/18639 0.0648148148148148 0.951996322563698 0.608738594535524 0.954035616448699 GO:0070851 growth factor receptor binding 9/1269 139/18639 0.0647482014388489 0.951017909076994 0.610772203286462 0.954035616448699 GO:0140101 catalytic activity, acting on a tRNA 9/1269 139/18639 0.0647482014388489 0.951017909076994 0.610772203286462 0.954035616448699 GO:0030276 clathrin binding 3/1269 46/18639 0.0652173913043478 0.95790934320074 0.614530586887552 0.954035616448699 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1269 30/18639 0.0666666666666667 0.97919621749409 0.615322430626747 0.954035616448699 GO:0032452 histone demethylase activity 2/1269 30/18639 0.0666666666666667 0.97919621749409 0.615322430626747 0.954035616448699 GO:0031406 carboxylic acid binding 12/1269 187/18639 0.0641711229946524 0.942541813630675 0.626441314914838 0.954035616448699 GO:0004065 arylsulfatase activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0004705 JUN kinase activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0005313 L-glutamate transmembrane transporter activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0008174 mRNA methyltransferase activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0008191 metalloendopeptidase inhibitor activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0008494 translation activator activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0019992 diacylglycerol binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0030983 mismatched DNA binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0031404 chloride ion binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0032036 myosin heavy chain binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0042043 neurexin family protein binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0046030 inositol trisphosphate phosphatase activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0071933 Arp2/3 complex binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0098821 BMP receptor activity 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:1901612 cardiolipin binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:1990825 sequence-specific mRNA binding 1/1269 14/18639 0.0714285714285714 1.04913880445795 0.627500272636996 0.954035616448699 GO:0005507 copper ion binding 4/1269 63/18639 0.0634920634920635 0.932567826184847 0.629512800510677 0.954035616448699 GO:0033293 monocarboxylic acid binding 5/1269 79/18639 0.0632911392405063 0.929616662177933 0.631559749323592 0.954035616448699 GO:0008327 methyl-CpG binding 2/1269 31/18639 0.0645161290322581 0.947609242736216 0.633331031372877 0.954035616448699 GO:0016411 acylglycerol O-acyltransferase activity 2/1269 31/18639 0.0645161290322581 0.947609242736216 0.633331031372877 0.954035616448699 GO:0017147 Wnt-protein binding 2/1269 31/18639 0.0645161290322581 0.947609242736216 0.633331031372877 0.954035616448699 GO:0070325 lipoprotein particle receptor binding 2/1269 31/18639 0.0645161290322581 0.947609242736216 0.633331031372877 0.954035616448699 GO:0072349 modified amino acid transmembrane transporter activity 2/1269 31/18639 0.0645161290322581 0.947609242736216 0.633331031372877 0.954035616448699 GO:0140457 protein demethylase activity 2/1269 31/18639 0.0645161290322581 0.947609242736216 0.633331031372877 0.954035616448699 GO:0005125 cytokine activity 15/1269 234/18639 0.0641025641025641 0.941534824513548 0.633643861252176 0.954035616448699 GO:0004674 protein serine/threonine kinase activity 28/1269 433/18639 0.0646651270207852 0.949797716737916 0.640279909107434 0.960470088209148 GO:0043177 organic acid binding 12/1269 189/18639 0.0634920634920635 0.932567826184847 0.64111456513048 0.960470088209148 GO:0001664 G protein-coupled receptor binding 19/1269 297/18639 0.063973063973064 0.939632733958975 0.644970402891718 0.960470088209148 GO:0008378 galactosyltransferase activity 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0015106 bicarbonate transmembrane transporter activity 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0022884 macromolecule transmembrane transporter activity 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0071813 lipoprotein particle binding 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0071814 protein-lipid complex binding 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0120015 sterol transfer activity 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0140142 nucleocytoplasmic carrier activity 2/1269 32/18639 0.0625 0.917996453900709 0.650672858385807 0.960470088209148 GO:0000774 adenyl-nucleotide exchange factor activity 1/1269 15/18639 0.0666666666666667 0.97919621749409 0.652880254061085 0.960470088209148 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1269 15/18639 0.0666666666666667 0.97919621749409 0.652880254061085 0.960470088209148 GO:0004953 icosanoid receptor activity 1/1269 15/18639 0.0666666666666667 0.97919621749409 0.652880254061085 0.960470088209148 GO:0010181 FMN binding 1/1269 15/18639 0.0666666666666667 0.97919621749409 0.652880254061085 0.960470088209148 GO:0048531 beta-1,3-galactosyltransferase activity 1/1269 15/18639 0.0666666666666667 0.97919621749409 0.652880254061085 0.960470088209148 GO:0051371 muscle alpha-actinin binding 1/1269 15/18639 0.0666666666666667 0.97919621749409 0.652880254061085 0.960470088209148 GO:0015101 organic cation transmembrane transporter activity 5/1269 81/18639 0.0617283950617284 0.906663164346379 0.65358890620491 0.960470088209148 GO:0038024 cargo receptor activity 4/1269 65/18639 0.0615384615384615 0.903873431533006 0.654090013298653 0.960470088209148 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 31/1269 484/18639 0.0640495867768595 0.940756696559405 0.665711792666535 0.974593800502562 GO:0008235 metalloexopeptidase activity 4/1269 66/18639 0.0606060606060606 0.890178379540082 0.665960608398192 0.974593800502562 GO:0019956 chemokine binding 2/1269 33/18639 0.0606060606060606 0.890178379540082 0.667355156190716 0.974593800502562 GO:0140311 protein sequestering activity 2/1269 33/18639 0.0606060606060606 0.890178379540082 0.667355156190716 0.974593800502562 GO:0035401 histone H3Y41 kinase activity 7/1269 115/18639 0.0608695652173913 0.894048720320691 0.674321785847081 0.975995932364419 GO:0140801 histone H2AXY142 kinase activity 7/1269 115/18639 0.0608695652173913 0.894048720320691 0.674321785847081 0.975995932364419 GO:0005254 chloride channel activity 5/1269 83/18639 0.0602409638554217 0.884815859181406 0.674758930057603 0.975995932364419 GO:0004707 MAP kinase activity 1/1269 16/18639 0.0625 0.917996453900709 0.676532259945776 0.975995932364419 GO:0005024 transforming growth factor beta receptor activity 1/1269 16/18639 0.0625 0.917996453900709 0.676532259945776 0.975995932364419 GO:0005149 interleukin-1 receptor binding 1/1269 16/18639 0.0625 0.917996453900709 0.676532259945776 0.975995932364419 GO:0008142 oxysterol binding 1/1269 16/18639 0.0625 0.917996453900709 0.676532259945776 0.975995932364419 GO:0008296 3'-5'-DNA exonuclease activity 1/1269 16/18639 0.0625 0.917996453900709 0.676532259945776 0.975995932364419 GO:0055102 lipase inhibitor activity 1/1269 16/18639 0.0625 0.917996453900709 0.676532259945776 0.975995932364419 GO:0009055 electron transfer activity 7/1269 116/18639 0.0603448275862069 0.886341403766202 0.683106643873999 0.976465599074953 GO:0008175 tRNA methyltransferase activity 2/1269 34/18639 0.0588235294117647 0.863996662494785 0.683387272735947 0.976465599074953 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1269 34/18639 0.0588235294117647 0.863996662494785 0.683387272735947 0.976465599074953 GO:0005048 signal sequence binding 3/1269 51/18639 0.0588235294117647 0.863996662494785 0.684066329943638 0.976465599074953 GO:0016830 carbon-carbon lyase activity 3/1269 51/18639 0.0588235294117647 0.863996662494785 0.684066329943638 0.976465599074953 GO:0030695 GTPase regulator activity 31/1269 489/18639 0.0633946830265849 0.93113750743303 0.687703759508929 0.976465599074953 GO:0060589 nucleoside-triphosphatase regulator activity 31/1269 490/18639 0.063265306122449 0.929237226805616 0.692008597659165 0.976465599074953 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 11/1269 181/18639 0.0607734806629834 0.892637435837154 0.694965685453414 0.976465599074953 GO:0001216 DNA-binding transcription activator activity 31/1269 491/18639 0.0631364562118126 0.927344686628822 0.696281388805851 0.976465599074953 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0005092 GDP-dissociation inhibitor activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0008484 sulfuric ester hydrolase activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0045125 bioactive lipid receptor activity 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0046965 nuclear retinoid X receptor binding 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0048038 quinone binding 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0070402 NADPH binding 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0070492 oligosaccharide binding 1/1269 17/18639 0.0588235294117647 0.863996662494785 0.698573851640391 0.976465599074953 GO:0005343 organic acid:sodium symporter activity 2/1269 35/18639 0.0571428571428571 0.839311043566363 0.698780339843161 0.976465599074953 GO:0034061 DNA polymerase activity 2/1269 35/18639 0.0571428571428571 0.839311043566363 0.698780339843161 0.976465599074953 GO:0050660 flavin adenine dinucleotide binding 5/1269 86/18639 0.0581395348837209 0.853950189675078 0.704866498194696 0.978032449702729 GO:0016874 ligase activity 10/1269 167/18639 0.0598802395209581 0.879517560623434 0.707785456395108 0.978032449702729 GO:0005246 calcium channel regulator activity 3/1269 53/18639 0.0566037735849057 0.831393014853473 0.709119298314908 0.978032449702729 GO:0051018 protein kinase A binding 3/1269 53/18639 0.0566037735849057 0.831393014853473 0.709119298314908 0.978032449702729 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1269 70/18639 0.0571428571428571 0.839311043566363 0.710615005366781 0.978032449702729 GO:0004033 aldo-keto reductase (NADPH) activity 2/1269 36/18639 0.0555555555555556 0.815996847911742 0.713546987362546 0.978032449702729 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1269 36/18639 0.0555555555555556 0.815996847911742 0.713546987362546 0.978032449702729 GO:0005484 SNAP receptor activity 2/1269 36/18639 0.0555555555555556 0.815996847911742 0.713546987362546 0.978032449702729 GO:0005201 extracellular matrix structural constituent 10/1269 168/18639 0.0595238095238095 0.874282337048294 0.71474814749635 0.978032449702729 GO:0016247 channel regulator activity 10/1269 168/18639 0.0595238095238095 0.874282337048294 0.71474814749635 0.978032449702729 GO:0008237 metallopeptidase activity 11/1269 184/18639 0.0597826086956522 0.878083564600678 0.715222870985185 0.978032449702729 GO:0002020 protease binding 8/1269 136/18639 0.0588235294117647 0.863996662494785 0.715293508403666 0.978032449702729 GO:0044325 transmembrane transporter binding 8/1269 136/18639 0.0588235294117647 0.863996662494785 0.715293508403666 0.978032449702729 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:0016854 racemase and epimerase activity 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:0032393 MHC class I receptor activity 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:0034185 apolipoprotein binding 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:1901611 phosphatidylglycerol binding 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:1990381 ubiquitin-specific protease binding 1/1269 18/18639 0.0555555555555556 0.815996847911742 0.719114598191155 0.978032449702729 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/1269 54/18639 0.0555555555555556 0.815996847911742 0.721060336490575 0.979432655283894 GO:0042277 peptide binding 15/1269 249/18639 0.0602409638554217 0.884815859181406 0.725396887635171 0.982762213468521 GO:0030551 cyclic nucleotide binding 2/1269 37/18639 0.0540540540540541 0.793942879049262 0.72770108793044 0.982762213468521 GO:0141108 transporter regulator activity 10/1269 170/18639 0.0588235294117647 0.863996662494785 0.728350901853085 0.982762213468521 GO:0005518 collagen binding 4/1269 72/18639 0.0555555555555556 0.815996847911742 0.731241492634298 0.982762213468521 GO:0008374 O-acyltransferase activity 3/1269 55/18639 0.0545454545454545 0.801160541586073 0.732615943130416 0.982762213468521 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0005520 insulin-like growth factor binding 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0022840 leak channel activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0022842 narrow pore channel activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0030506 ankyrin binding 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0042800 histone H3K4 methyltransferase activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0043395 heparan sulfate proteoglycan binding 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0046527 glucosyltransferase activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0070003 threonine-type peptidase activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0141147 intracellularly calcium-gated channel activity 1/1269 19/18639 0.0526315789473684 0.773049645390071 0.738256619290743 0.982762213468521 GO:0005501 retinoid binding 2/1269 38/18639 0.0526315789473684 0.773049645390071 0.741257529492495 0.982762213468521 GO:0019840 isoprenoid binding 2/1269 38/18639 0.0526315789473684 0.773049645390071 0.741257529492495 0.982762213468521 GO:0043531 ADP binding 2/1269 38/18639 0.0526315789473684 0.773049645390071 0.741257529492495 0.982762213468521 GO:0019210 kinase inhibitor activity 5/1269 90/18639 0.0555555555555556 0.815996847911742 0.741898134957059 0.982762213468521 GO:0004713 protein tyrosine kinase activity 8/1269 140/18639 0.0571428571428571 0.839311043566363 0.744764012136114 0.985337535858299 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1269 39/18639 0.0512820512820513 0.753227859610838 0.754232012999474 0.989256168514695 GO:0000339 RNA cap binding 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0001972 retinoic acid binding 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0016408 C-acyltransferase activity 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0016505 peptidase activator activity involved in apoptotic process 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0042288 MHC class I protein binding 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0061608 nuclear import signal receptor activity 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0140664 ATP-dependent DNA damage sensor activity 1/1269 20/18639 0.05 0.734397163120567 0.75609509137023 0.989256168514695 GO:0005096 GTPase activator activity 16/1269 271/18639 0.0590405904059041 0.867184842061187 0.758075510516461 0.989256168514695 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/1269 58/18639 0.0517241379310345 0.759721203228173 0.7650191735025 0.989256168514695 GO:0032451 demethylase activity 2/1269 40/18639 0.05 0.734397163120567 0.766640872906707 0.989256168514695 GO:0140662 ATP-dependent protein folding chaperone 2/1269 40/18639 0.05 0.734397163120567 0.766640872906707 0.989256168514695 GO:0099106 ion channel regulator activity 9/1269 160/18639 0.05625 0.826196808510638 0.768848407872633 0.989256168514695 GO:0008373 sialyltransferase activity 1/1269 21/18639 0.0476190476190476 0.699425869638636 0.772718719333664 0.989256168514695 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1269 21/18639 0.0476190476190476 0.699425869638636 0.772718719333664 0.989256168514695 GO:0015174 basic amino acid transmembrane transporter activity 1/1269 21/18639 0.0476190476190476 0.699425869638636 0.772718719333664 0.989256168514695 GO:0036122 BMP binding 1/1269 21/18639 0.0476190476190476 0.699425869638636 0.772718719333664 0.989256168514695 GO:0051428 peptide hormone receptor binding 1/1269 21/18639 0.0476190476190476 0.699425869638636 0.772718719333664 0.989256168514695 GO:1904047 S-adenosyl-L-methionine binding 1/1269 21/18639 0.0476190476190476 0.699425869638636 0.772718719333664 0.989256168514695 GO:0005539 glycosaminoglycan binding 14/1269 242/18639 0.0578512396694215 0.849715725924623 0.773242858735645 0.989256168514695 GO:0005178 integrin binding 9/1269 161/18639 0.0559006211180124 0.82106515131492 0.7750680688673 0.989256168514695 GO:0015459 potassium channel regulator activity 3/1269 59/18639 0.0508474576271186 0.746844572664984 0.775085010008451 0.989256168514695 GO:0005319 lipid transporter activity 10/1269 178/18639 0.0561797752808989 0.825165351820862 0.77840220098714 0.989256168514695 GO:0140318 protein transporter activity 2/1269 41/18639 0.0487804878048781 0.716485037190797 0.778500918313734 0.989256168514695 GO:0005200 structural constituent of cytoskeleton 6/1269 112/18639 0.0535714285714286 0.786854103343465 0.782471400884137 0.989256168514695 GO:0035591 signaling adaptor activity 7/1269 129/18639 0.0542635658914729 0.797020177030073 0.783202319610445 0.989256168514695 GO:0004867 serine-type endopeptidase inhibitor activity 5/1269 95/18639 0.0526315789473684 0.773049645390071 0.783226175971893 0.989256168514695 GO:0098531 ligand-modulated transcription factor activity 3/1269 60/18639 0.05 0.734397163120567 0.784794104585319 0.989256168514695 GO:0008093 cytoskeletal anchor activity 1/1269 22/18639 0.0454545454545455 0.667633784655061 0.788210176265965 0.989256168514695 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/1269 130/18639 0.0538461538461538 0.79088925259138 0.789812818835318 0.989256168514695 GO:0019894 kinesin binding 2/1269 42/18639 0.0476190476190476 0.699425869638636 0.789829292769209 0.989256168514695 GO:0048487 beta-tubulin binding 2/1269 42/18639 0.0476190476190476 0.699425869638636 0.789829292769209 0.989256168514695 GO:0016836 hydro-lyase activity 3/1269 61/18639 0.0491803278688525 0.722357865364493 0.794153590234261 0.989256168514695 GO:0016835 carbon-oxygen lyase activity 4/1269 79/18639 0.0506329113924051 0.743693329742347 0.794719873735855 0.989256168514695 GO:0035173 histone kinase activity 21/1269 360/18639 0.0583333333333333 0.856796690307329 0.799374233165803 0.989256168514695 GO:0003887 DNA-directed DNA polymerase activity 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:0016493 C-C chemokine receptor activity 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:0099186 structural constituent of postsynapse 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:0140103 catalytic activity, acting on a glycoprotein 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1269 23/18639 0.0434782608695652 0.638606228800493 0.802646513286886 0.989256168514695 GO:0106310 protein serine kinase activity 21/1269 361/18639 0.0581717451523546 0.854423292273236 0.80326293383808 0.989256168514695 GO:0042626 ATPase-coupled transmembrane transporter activity 5/1269 98/18639 0.0510204081632653 0.74938486032711 0.805452459449666 0.989256168514695 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/1269 44/18639 0.0454545454545455 0.667633784655061 0.810960550494349 0.989256168514695 GO:0043014 alpha-tubulin binding 2/1269 44/18639 0.0454545454545455 0.667633784655061 0.810960550494349 0.989256168514695 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0015149 hexose transmembrane transporter activity 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0019957 C-C chemokine binding 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0030552 cAMP binding 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0055056 D-glucose transmembrane transporter activity 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1269 24/18639 0.0416666666666667 0.611997635933806 0.816099541576473 0.989256168514695 GO:0140303 intramembrane lipid transporter activity 2/1269 45/18639 0.0444444444444444 0.652797478329393 0.820798357721035 0.989256168514695 GO:0022853 active monoatomic ion transmembrane transporter activity 6/1269 118/18639 0.0508474576271186 0.746844572664984 0.822299630189924 0.989256168514695 GO:0019838 growth factor binding 7/1269 136/18639 0.0514705882352941 0.755997079682937 0.82631477009708 0.989256168514695 GO:0120013 lipid transfer activity 3/1269 65/18639 0.0461538461538462 0.677905073649754 0.828248333503114 0.989256168514695 GO:0003707 nuclear steroid receptor activity 1/1269 25/18639 0.04 0.587517730496454 0.82863618846014 0.989256168514695 GO:0004709 MAP kinase kinase kinase activity 1/1269 25/18639 0.04 0.587517730496454 0.82863618846014 0.989256168514695 GO:0008139 nuclear localization sequence binding 1/1269 25/18639 0.04 0.587517730496454 0.82863618846014 0.989256168514695 GO:0015662 P-type ion transporter activity 1/1269 25/18639 0.04 0.587517730496454 0.82863618846014 0.989256168514695 GO:0120020 cholesterol transfer activity 1/1269 25/18639 0.04 0.587517730496454 0.82863618846014 0.989256168514695 GO:0140358 P-type transmembrane transporter activity 1/1269 25/18639 0.04 0.587517730496454 0.82863618846014 0.989256168514695 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/1269 46/18639 0.0434782608695652 0.638606228800493 0.830174165486193 0.989256168514695 GO:0030291 protein serine/threonine kinase inhibitor activity 2/1269 46/18639 0.0434782608695652 0.638606228800493 0.830174165486193 0.989256168514695 GO:0004860 protein kinase inhibitor activity 4/1269 84/18639 0.0476190476190476 0.699425869638636 0.832226902623024 0.989256168514695 GO:0008238 exopeptidase activity 5/1269 102/18639 0.0490196078431373 0.719997218745654 0.832228063256282 0.989256168514695 GO:0015171 amino acid transmembrane transporter activity 5/1269 102/18639 0.0490196078431373 0.719997218745654 0.832228063256282 0.989256168514695 GO:0141003 histone H2AX kinase activity 20/1269 354/18639 0.0564971751412429 0.829827302961093 0.836524171463357 0.989256168514695 GO:0005253 monoatomic anion channel activity 5/1269 103/18639 0.0485436893203883 0.713006954485988 0.838431639623566 0.989256168514695 GO:0016791 phosphatase activity 15/1269 273/18639 0.0549450549450549 0.807029849583041 0.83893062975416 0.989256168514695 GO:0001784 phosphotyrosine residue binding 2/1269 47/18639 0.0425531914893617 0.62501886223027 0.839105222318335 0.989256168514695 GO:0140359 ABC-type transporter activity 2/1269 47/18639 0.0425531914893617 0.62501886223027 0.839105222318335 0.989256168514695 GO:0140938 histone H3 methyltransferase activity 2/1269 47/18639 0.0425531914893617 0.62501886223027 0.839105222318335 0.989256168514695 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0004950 chemokine receptor activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0005112 Notch binding 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0005160 transforming growth factor beta receptor binding 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0005227 calcium-activated cation channel activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0015145 monosaccharide transmembrane transporter activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0052742 phosphatidylinositol kinase activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0097602 cullin family protein binding 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0120014 phospholipid transfer activity 1/1269 26/18639 0.0384615384615385 0.564920894708129 0.84031882931348 0.989256168514695 GO:0050840 extracellular matrix binding 3/1269 67/18639 0.0447761194029851 0.657669101302001 0.843402579114612 0.989256168514695 GO:1901681 sulfur compound binding 15/1269 275/18639 0.0545454545454545 0.801160541586073 0.846519193971802 0.989256168514695 GO:0140996 histone H3 kinase activity 20/1269 357/18639 0.0560224089635854 0.822853964280748 0.846642743088908 0.989256168514695 GO:0038187 pattern recognition receptor activity 2/1269 48/18639 0.0416666666666667 0.611997635933806 0.847608571470368 0.989256168514695 GO:0005548 phospholipid transporter activity 3/1269 68/18639 0.0441176470588235 0.647997496871089 0.8505355351089 0.989256168514695 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/1269 68/18639 0.0441176470588235 0.647997496871089 0.8505355351089 0.989256168514695 GO:0005044 scavenger receptor activity 1/1269 27/18639 0.037037037037037 0.543997898607828 0.851205596927577 0.989256168514695 GO:0008395 steroid hydroxylase activity 1/1269 27/18639 0.037037037037037 0.543997898607828 0.851205596927577 0.989256168514695 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 13/1269 243/18639 0.0534979423868313 0.785774742433529 0.851239759939135 0.989256168514695 GO:0016763 pentosyltransferase activity 2/1269 49/18639 0.0408163265306122 0.599507888261688 0.855700998936497 0.989256168514695 GO:0004497 monooxygenase activity 5/1269 106/18639 0.0471698113207547 0.692827512377894 0.85591959839669 0.989256168514695 GO:0016279 protein-lysine N-methyltransferase activity 3/1269 69/18639 0.0434782608695652 0.638606228800493 0.857383646808567 0.989256168514695 GO:0004676 3-phosphoinositide-dependent protein kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0004711 ribosomal protein S6 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0035175 histone H3S10 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0035979 histone H2AXS139 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0044022 histone H3S28 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0044023 histone H4S1 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0044024 histone H2AS1 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0044025 histone H2BS14 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0072354 histone H3T3 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0072371 histone H2AS121 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0072518 Rho-dependent protein serine/threonine kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0140823 histone H2BS36 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0140855 histone H3S57 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0140995 histone H2A kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0140997 histone H4 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0140998 histone H2B kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:1990244 histone H2AT120 kinase activity 13/1269 245/18639 0.0530612244897959 0.779360254740194 0.858811932838529 0.989256168514695 GO:0051119 sugar transmembrane transporter activity 1/1269 28/18639 0.0357142857142857 0.524569402228977 0.861350669864334 0.989256168514695 GO:0051393 alpha-actinin binding 1/1269 28/18639 0.0357142857142857 0.524569402228977 0.861350669864334 0.989256168514695 GO:0141052 histone H3 demethylase activity 1/1269 28/18639 0.0357142857142857 0.524569402228977 0.861350669864334 0.989256168514695 GO:0004677 DNA-dependent protein kinase activity 13/1269 246/18639 0.0528455284552846 0.776192123623364 0.86248353873008 0.989256168514695 GO:0140857 histone H3T45 kinase activity 13/1269 246/18639 0.0528455284552846 0.776192123623364 0.86248353873008 0.989256168514695 GO:0005006 epidermal growth factor receptor activity 2/1269 50/18639 0.04 0.587517730496454 0.86339898948786 0.989256168514695 GO:0032813 tumor necrosis factor receptor superfamily binding 2/1269 50/18639 0.04 0.587517730496454 0.86339898948786 0.989256168514695 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/1269 89/18639 0.0449438202247191 0.66013228145669 0.863839982006744 0.989256168514695 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/1269 89/18639 0.0449438202247191 0.66013228145669 0.863839982006744 0.989256168514695 GO:0016278 lysine N-methyltransferase activity 3/1269 70/18639 0.0428571428571429 0.629483282674772 0.863955377022378 0.989256168514695 GO:0035402 histone H3T11 kinase activity 13/1269 247/18639 0.0526315789473684 0.773049645390071 0.866079852150185 0.989256168514695 GO:0035403 histone H3T6 kinase activity 13/1269 247/18639 0.0526315789473684 0.773049645390071 0.866079852150185 0.989256168514695 GO:0008083 growth factor activity 8/1269 162/18639 0.0493827160493827 0.725330531477103 0.86875888198856 0.989256168514695 GO:0140793 histone H2AXY142 phosphatase activity 4/1269 90/18639 0.0444444444444444 0.652797478329393 0.869511695823008 0.989256168514695 GO:0004679 AMP-activated protein kinase activity 13/1269 248/18639 0.0524193548387097 0.769932509723176 0.869601671861676 0.989256168514695 GO:0016597 amino acid binding 2/1269 51/18639 0.0392156862745098 0.575997774996523 0.87071868987742 0.989256168514695 GO:0035250 UDP-galactosyltransferase activity 1/1269 29/18639 0.0344827586206897 0.506480802152115 0.870804541227622 0.989256168514695 GO:0043236 laminin binding 1/1269 29/18639 0.0344827586206897 0.506480802152115 0.870804541227622 0.989256168514695 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/1269 29/18639 0.0344827586206897 0.506480802152115 0.870804541227622 0.989256168514695 GO:0004620 phospholipase activity 5/1269 109/18639 0.0458715596330275 0.673758865248227 0.871799112994947 0.989334662199149 GO:0004222 metalloendopeptidase activity 5/1269 110/18639 0.0454545454545455 0.667633784655061 0.876752195163812 0.990840520287411 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/1269 52/18639 0.0384615384615385 0.564920894708129 0.877675878442974 0.990840520287411 GO:0015215 nucleotide transmembrane transporter activity 1/1269 30/18639 0.0333333333333333 0.489598108747045 0.879614269179376 0.990840520287411 GO:0022839 monoatomic ion-gated channel activity 1/1269 30/18639 0.0333333333333333 0.489598108747045 0.879614269179376 0.990840520287411 GO:0033612 receptor serine/threonine kinase binding 1/1269 30/18639 0.0333333333333333 0.489598108747045 0.879614269179376 0.990840520287411 GO:0070566 adenylyltransferase activity 1/1269 30/18639 0.0333333333333333 0.489598108747045 0.879614269179376 0.990840520287411 GO:0098918 structural constituent of synapse 1/1269 30/18639 0.0333333333333333 0.489598108747045 0.879614269179376 0.990840520287411 GO:0017046 peptide hormone binding 2/1269 53/18639 0.0377358490566038 0.554262009902315 0.88428594040878 0.994751575666826 GO:0015399 primary active transmembrane transporter activity 8/1269 166/18639 0.0481927710843374 0.707852687345125 0.884947379288261 0.994751575666826 GO:0005164 tumor necrosis factor receptor binding 1/1269 31/18639 0.032258064516129 0.473804621368108 0.887823710439593 0.996936498382274 GO:0042562 hormone binding 4/1269 94/18639 0.0425531914893617 0.62501886223027 0.890206535070982 0.998563259171962 GO:0005179 hormone activity 6/1269 132/18639 0.0454545454545455 0.667633784655061 0.892783915987914 0.999999990016351 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/1269 32/18639 0.03125 0.458998226950355 0.895473737925199 0.999999990016351 GO:0042910 xenobiotic transmembrane transporter activity 1/1269 32/18639 0.03125 0.458998226950355 0.895473737925199 0.999999990016351 GO:0043425 bHLH transcription factor binding 1/1269 32/18639 0.03125 0.458998226950355 0.895473737925199 0.999999990016351 GO:0046943 carboxylic acid transmembrane transporter activity 9/1269 188/18639 0.0478723404255319 0.703146220009054 0.900078608672069 0.999999990016351 GO:0005126 cytokine receptor binding 14/1269 275/18639 0.0509090909090909 0.747749838813669 0.900525041683313 0.999999990016351 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/1269 33/18639 0.0303030303030303 0.445089189770041 0.902602443604402 0.999999990016351 GO:0030296 protein tyrosine kinase activator activity 1/1269 33/18639 0.0303030303030303 0.445089189770041 0.902602443604402 0.999999990016351 GO:0071889 14-3-3 protein binding 1/1269 33/18639 0.0303030303030303 0.445089189770041 0.902602443604402 0.999999990016351 GO:0005342 organic acid transmembrane transporter activity 9/1269 189/18639 0.0476190476190476 0.699425869638636 0.903286748956363 0.999999990016351 GO:0008201 heparin binding 8/1269 172/18639 0.0465116279069767 0.683160151740063 0.906094938882581 0.999999990016351 GO:0019199 transmembrane receptor protein kinase activity 3/1269 78/18639 0.0384615384615385 0.564920894708129 0.907578247631913 0.999999990016351 GO:0016779 nucleotidyltransferase activity 6/1269 136/18639 0.0441176470588235 0.647997496871089 0.907920367331949 0.999999990016351 GO:0004725 protein tyrosine phosphatase activity 4/1269 98/18639 0.0408163265306122 0.599507888261688 0.90796974341112 0.999999990016351 GO:0008376 acetylgalactosaminyltransferase activity 1/1269 34/18639 0.0294117647058824 0.431998331247393 0.909245327570112 0.999999990016351 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1269 34/18639 0.0294117647058824 0.431998331247393 0.909245327570112 0.999999990016351 GO:0051427 hormone receptor binding 1/1269 34/18639 0.0294117647058824 0.431998331247393 0.909245327570112 0.999999990016351 GO:0090482 vitamin transmembrane transporter activity 1/1269 34/18639 0.0294117647058824 0.431998331247393 0.909245327570112 0.999999990016351 GO:0016229 steroid dehydrogenase activity 1/1269 35/18639 0.0285714285714286 0.419655521783181 0.915435474267964 0.999999990016351 GO:0004879 nuclear receptor activity 2/1269 59/18639 0.0338983050847458 0.497896381776656 0.917464628980986 0.999999990016351 GO:0070888 E-box binding 2/1269 59/18639 0.0338983050847458 0.497896381776656 0.917464628980986 0.999999990016351 GO:0016409 palmitoyltransferase activity 1/1269 36/18639 0.0277777777777778 0.407998423955871 0.921203716750976 0.999999990016351 GO:0015108 chloride transmembrane transporter activity 5/1269 121/18639 0.0413223140495868 0.606939804231874 0.921268904445684 0.999999990016351 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/1269 60/18639 0.0333333333333333 0.489598108747045 0.922039474649802 0.999999990016351 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/1269 60/18639 0.0333333333333333 0.489598108747045 0.922039474649802 0.999999990016351 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 13/1269 268/18639 0.0485074626865672 0.712474859743834 0.925762968583117 0.999999990016351 GO:0022829 wide pore channel activity 1/1269 37/18639 0.027027027027027 0.396971439524631 0.926578789773768 0.999999990016351 GO:0023023 MHC protein complex binding 1/1269 37/18639 0.027027027027027 0.396971439524631 0.926578789773768 0.999999990016351 GO:0030280 structural constituent of skin epidermis 1/1269 37/18639 0.027027027027027 0.396971439524631 0.926578789773768 0.999999990016351 GO:0043394 proteoglycan binding 1/1269 37/18639 0.027027027027027 0.396971439524631 0.926578789773768 0.999999990016351 GO:0008514 organic anion transmembrane transporter activity 13/1269 269/18639 0.0483271375464684 0.709826254317277 0.927930100115955 0.999999990016351 GO:0042887 amide transmembrane transporter activity 1/1269 38/18639 0.0263157894736842 0.386524822695035 0.931587472484073 0.999999990016351 GO:0019955 cytokine binding 6/1269 144/18639 0.0416666666666667 0.611997635933806 0.932725231272973 0.999999990016351 GO:1901682 sulfur compound transmembrane transporter activity 2/1269 63/18639 0.0317460317460317 0.466283913092424 0.934370806103477 0.999999990016351 GO:0015144 carbohydrate transmembrane transporter activity 1/1269 40/18639 0.025 0.367198581560284 0.940603794456626 0.999999990016351 GO:0050997 quaternary ammonium group binding 1/1269 40/18639 0.025 0.367198581560284 0.940603794456626 0.999999990016351 GO:0071949 FAD binding 1/1269 40/18639 0.025 0.367198581560284 0.940603794456626 0.999999990016351 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/1269 88/18639 0.0340909090909091 0.500725338491296 0.944143202368909 0.999999990016351 GO:0001727 lipid kinase activity 1/1269 41/18639 0.024390243902439 0.358242518595399 0.944656366360199 0.999999990016351 GO:0004812 aminoacyl-tRNA ligase activity 1/1269 41/18639 0.024390243902439 0.358242518595399 0.944656366360199 0.999999990016351 GO:0008227 G protein-coupled amine receptor activity 1/1269 41/18639 0.024390243902439 0.358242518595399 0.944656366360199 0.999999990016351 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/1269 41/18639 0.024390243902439 0.358242518595399 0.944656366360199 0.999999990016351 GO:0042287 MHC protein binding 1/1269 41/18639 0.024390243902439 0.358242518595399 0.944656366360199 0.999999990016351 GO:0001217 DNA-binding transcription repressor activity 13/1269 278/18639 0.0467625899280576 0.686846267666718 0.945124996879193 0.999999990016351 GO:0016298 lipase activity 5/1269 130/18639 0.0384615384615385 0.564920894708129 0.946430534117514 0.999999990016351 GO:0030246 carbohydrate binding 13/1269 280/18639 0.0464285714285714 0.68194022289767 0.948423660216444 0.999999990016351 GO:0008375 acetylglucosaminyltransferase activity 1/1269 43/18639 0.0232558139534884 0.341580075870031 0.951951428959897 0.999999990016351 GO:0030547 signaling receptor inhibitor activity 1/1269 44/18639 0.0227272727272727 0.333816892327531 0.95523028659863 0.999999990016351 GO:0042605 peptide antigen binding 1/1269 45/18639 0.0222222222222222 0.326398739164697 0.958285557709485 0.999999990016351 GO:0015294 solute:monoatomic cation symporter activity 4/1269 116/18639 0.0344827586206897 0.506480802152115 0.960085816195738 0.999999990016351 GO:0004180 carboxypeptidase activity 1/1269 46/18639 0.0217391304347826 0.319303114400247 0.961132477536669 0.999999990016351 GO:0004896 cytokine receptor activity 3/1269 96/18639 0.03125 0.458998226950355 0.963174909431155 0.999999990016351 GO:0099095 ligand-gated monoatomic anion channel activity 1/1269 47/18639 0.0212765957446809 0.312509431115135 0.963785243954459 0.999999990016351 GO:0042578 phosphoric ester hydrolase activity 17/1269 363/18639 0.046831955922865 0.68786511146279 0.964000461723201 0.999999990016351 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/1269 48/18639 0.0208333333333333 0.305998817966903 0.966257088049865 0.999999990016351 GO:0005004 GPI-linked ephrin receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0005008 hepatocyte growth factor receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0005009 insulin receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0005011 macrophage colony-stimulating factor receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0005020 stem cell factor receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0008288 boss receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0036332 placental growth factor receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0038062 protein tyrosine kinase collagen receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0060175 brain-derived neurotrophic factor receptor activity 1/1269 49/18639 0.0204081632653061 0.299753944130844 0.968560339906393 0.999999990016351 GO:0005007 fibroblast growth factor receptor activity 1/1269 50/18639 0.02 0.293758865248227 0.970706489914935 0.999999990016351 GO:0005017 platelet-derived growth factor receptor activity 1/1269 50/18639 0.02 0.293758865248227 0.970706489914935 0.999999990016351 GO:0005019 platelet-derived growth factor beta-receptor activity 1/1269 50/18639 0.02 0.293758865248227 0.970706489914935 0.999999990016351 GO:0015605 organophosphate ester transmembrane transporter activity 1/1269 50/18639 0.02 0.293758865248227 0.970706489914935 0.999999990016351 GO:0005010 insulin-like growth factor receptor activity 1/1269 51/18639 0.0196078431372549 0.287998887498262 0.972706245915685 0.999999990016351 GO:0005021 vascular endothelial growth factor receptor activity 1/1269 51/18639 0.0196078431372549 0.287998887498262 0.972706245915685 0.999999990016351 GO:0005030 neurotrophin receptor activity 1/1269 51/18639 0.0196078431372549 0.287998887498262 0.972706245915685 0.999999990016351 GO:0015293 symporter activity 5/1269 146/18639 0.0342465753424658 0.503011755562032 0.973920174830368 0.999999990016351 GO:0015370 solute:sodium symporter activity 2/1269 79/18639 0.0253164556962025 0.371846664871173 0.974420550413917 0.999999990016351 GO:0046332 SMAD binding 2/1269 79/18639 0.0253164556962025 0.371846664871173 0.974420550413917 0.999999990016351 GO:0005003 ephrin receptor activity 1/1269 53/18639 0.0188679245283019 0.277131004951158 0.976305810416781 0.999999990016351 GO:0005005 transmembrane-ephrin receptor activity 1/1269 53/18639 0.0188679245283019 0.277131004951158 0.976305810416781 0.999999990016351 GO:0008146 sulfotransferase activity 1/1269 53/18639 0.0188679245283019 0.277131004951158 0.976305810416781 0.999999990016351 GO:0038064 collagen receptor activity 1/1269 53/18639 0.0188679245283019 0.277131004951158 0.976305810416781 0.999999990016351 GO:0008509 monoatomic anion transmembrane transporter activity 5/1269 149/18639 0.0335570469798658 0.492884002094341 0.977315238884205 0.999999990016351 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/1269 57/18639 0.0175438596491228 0.257683215130024 0.982144234230383 0.999999990016351 GO:0140375 immune receptor activity 5/1269 156/18639 0.032051282051282 0.470767412256774 0.983698594122874 0.999999990016351 GO:0008081 phosphoric diester hydrolase activity 2/1269 87/18639 0.0229885057471264 0.33765386810141 0.984226390311217 0.999999990016351 GO:0015026 coreceptor activity 1/1269 61/18639 0.0163934426229508 0.240785955121498 0.986544876340484 0.999999990016351 GO:0015103 inorganic anion transmembrane transporter activity 5/1269 165/18639 0.0303030303030303 0.445089189770041 0.989443393604388 0.999999990016351 GO:0008194 UDP-glycosyltransferase activity 4/1269 145/18639 0.0275862068965517 0.405184641721692 0.990712204965004 0.999999990016351 GO:0016500 protein-hormone receptor activity 1/1269 67/18639 0.0149253731343284 0.219223033767334 0.991199646924321 0.999999990016351 GO:0016782 transferase activity, transferring sulphur-containing groups 1/1269 70/18639 0.0142857142857143 0.209827760891591 0.992883226410948 0.999999990016351 GO:0004175 endopeptidase activity 16/1269 405/18639 0.0395061728395062 0.580264425181683 0.995011515865058 0.999999990016351 GO:0015078 proton transmembrane transporter activity 5/1269 185/18639 0.027027027027027 0.396971439524631 0.996116369334823 0.999999990016351 GO:0015085 calcium ion transmembrane transporter activity 3/1269 147/18639 0.0204081632653061 0.299753944130844 0.997884690556214 0.999999990016351 GO:0016758 hexosyltransferase activity 5/1269 197/18639 0.0253807106598985 0.372790438132268 0.997910791184458 0.999999990016351 GO:0016757 glycosyltransferase activity 8/1269 267/18639 0.0299625468164794 0.440088187637793 0.998113335531053 0.999999990016351 GO:0008528 G protein-coupled peptide receptor activity 2/1269 122/18639 0.0163934426229508 0.240785955121498 0.998220360229611 0.999999990016351 GO:0004252 serine-type endopeptidase activity 4/1269 176/18639 0.0227272727272727 0.333816892327531 0.998250628591503 0.999999990016351 GO:0001653 peptide receptor activity 2/1269 128/18639 0.015625 0.229499113475177 0.998785895480499 0.999999990016351 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/1269 130/18639 0.0153846153846154 0.225968357883252 0.998931665672608 0.999999990016351 GO:0005262 calcium channel activity 2/1269 131/18639 0.0152671755725191 0.224243408586433 0.998997929095224 0.999999990016351 GO:0015297 antiporter activity 2/1269 135/18639 0.0148148148148148 0.217599159443131 0.999224750215407 0.999999990016351 GO:0015291 secondary active transmembrane transporter activity 8/1269 287/18639 0.0278745644599303 0.409420021251884 0.999267569172093 0.999999990016351 GO:0022804 active transmembrane transporter activity 16/1269 457/18639 0.0350109409190372 0.514238713782454 0.999303057800454 0.999999990016351 GO:0008236 serine-type peptidase activity 4/1269 194/18639 0.0206185567010309 0.302844190977554 0.999362125193794 0.999999990016351 GO:0045182 translation regulator activity 11/1269 356/18639 0.0308988764044944 0.453840943501474 0.999372657568154 0.999999990016351 GO:0017171 serine hydrolase activity 4/1269 198/18639 0.0202020202020202 0.296726126513361 0.999491921338575 0.999999990016351 GO:0003823 antigen binding 3/1269 174/18639 0.0172413793103448 0.253240401076058 0.999576472068227 0.999999990016351 GO:0015081 sodium ion transmembrane transporter activity 2/1269 164/18639 0.0121951219512195 0.179121259297699 0.999881948453569 0.999999990016351 GO:0099094 ligand-gated monoatomic cation channel activity 1/1269 136/18639 0.00735294117647059 0.107999582811848 0.999933992244177 0.999999990016351 GO:0005244 voltage-gated monoatomic ion channel activity 2/1269 173/18639 0.0115606936416185 0.169802812282212 0.999934603779445 0.999999990016351 GO:0022832 voltage-gated channel activity 2/1269 175/18639 0.0114285714285714 0.167862208713273 0.999942669103053 0.999999990016351 GO:0015276 ligand-gated monoatomic ion channel activity 2/1269 186/18639 0.010752688172043 0.157934873789369 0.999972265673368 0.999999990016351 GO:0022834 ligand-gated channel activity 2/1269 188/18639 0.0106382978723404 0.156254715557568 0.99997570545094 0.999999990016351 GO:0030371 translation repressor activity 4/1269 329/18639 0.0121580547112462 0.178576817780077 0.999999813405837 0.999999990016351 GO:0005216 monoatomic ion channel activity 8/1269 448/18639 0.0178571428571429 0.262284701114488 0.999999855345622 0.999999990016351 GO:0046873 metal ion transmembrane transporter activity 8/1269 450/18639 0.0177777777777778 0.261118991331757 0.999999870872758 0.999999990016351 GO:0022836 gated channel activity 3/1269 318/18639 0.00943396226415094 0.138565502475579 0.999999954569676 0.999999990016351 GO:0005261 monoatomic cation channel activity 3/1269 341/18639 0.00879765395894428 0.129219442191302 0.999999990016351 0.999999990016351