category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	93/600	222/9376	6.54630630630631	RPS4X/RPL29/RPS3A/RPL11/RPSA/RPL8/RPS18/RPL18A/RPL14/RPL5/RPL6/RPL7A/RPS6/RPL18/RPS7/RPS2/RPL36/RPS15/RPS5/RPL37/RPL19/RPS24/RPS3/RPL13/RPL39/RPS26/RPL24/RPS27A/RPS14/RPL37A/RPL23A/RPL32/RPL12/RPL22/RPLP0/RPS13/MRPS15/RPLP2/RPL28/RPS19/RPL21/RPL7/RPL10/RPL38/RPL15/MRPL23/UBA52/RPL35/MRPL51/RPS23/RPL22L1/RPL27/RPL35A/RPS8/RPS27/RPL26/RPLP1/RPS25/RPS11/MRPL11/RPS16/RPL23/RPL10A/MRPL13/MRPL20/MRPL14/RPS12/MRPS16/RPL36AL/RPL4/MRPL27/MRPL37/MRPS33/MRPL12/RPL9/MRPL40/MRPS6/MRPL42/MRPL16/RPL31/MRPL41/MRPL21/MRPL17/MRPS31/MRPL52/MRPS7/MRPL35/MRPL47/MRPL22/MRPS12/RPL17/MRPS5/RPL26L1	21.8669312745417
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	66/600	238/9376	4.33344537815126	RPS4X/RPL29/RPS3A/RPL11/RPSA/RPL8/RPS18/RPL18A/RPL14/RPL5/RPL6/RPL7A/RPS6/RPL18/RPS7/RPS2/RPL36/RPS15/RPS5/RPL37/RPL19/RPS24/RPS3/RPL13/RPL39/RPS26/RPL24/RPS27A/RPS14/RPL37A/RPL23A/RPL32/RPL12/RPL22/RPLP0/RPS13/RPLP2/RPL28/RPS19/RPL21/RPL7/RPL10/RPL38/RPL15/UBA52/RPL35/RPS23/RPL22L1/RPL27/RPL35A/RPS8/RPS27/RPL26/RPLP1/RPS25/RPS11/RPS16/RPL23/RPL10A/RPS12/RPL36AL/RPL4/RPL9/RPL31/RPL17/RPL26L1	13.6197520407458
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/600	268/9376	3.32358208955224	TUBA1B/TUBA1C/CALM1/CALM3/TUBB/UQCRH/RPS27A/PSMA7/TUBB6/HSPA5/COX5B/COX5A/UBA52/NDUFS5/TUBB4B/NDUFA4/TXN2/PSMA4/PSMB2/COX8C/PSMB1/PSMB6/NDUFB11/UBE2L3/MT-CO3/SNCA/PSMB3/NDUFV3/VDAC1/PSMD11/SLC39A10/SLC25A5/NDUFV2/COX6B1/MT-CO2/COX6C/COX7C/PSMB5/PSMA1/MT-CO1/PARK7/NDUFA6/ADRM1/PSMA3/GNAS/VDAC2/NDUFC1/NDUFB4/NDUFV1/NDUFS7/NDUFB3/UQCRC1/NDUFB2/UQCRFS1/NDUFS8/PSMD4/PSMD12	10.0908293654359
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/600	275/9376	2.84121212121212	TUBA1B/TUBA1C/TUBB/UQCRH/PSMA7/CYBA/TUBB6/HSPA5/COX5B/COX5A/NDUFS5/TUBB4B/NDUFA4/PSMA4/PSMB2/COX8C/PSMB1/PSMB6/NDUFB11/MT-CO3/PSMB3/NDUFV3/VDAC1/PSMD11/SLC25A5/NDUFV2/COX6B1/MT-CO2/COX6C/COX7C/PSMB5/PSMA1/MT-CO1/NDUFA6/ADRM1/HSPA8/PSMA3/CAV1/VDAC2/NDUFC1/NDUFB4/NDUFV1/NDUFS7/NDUFB3/UQCRC1/NDUFB2/UQCRFS1/NDUFS8/PSMD4/PSMD12	8.10286440048409
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/600	205/9376	3.04910569105691	GAPDH/UQCRH/CYBA/MMP2/COX5B/COX5A/NDUFS5/NDUFA4/PPP1CA/COX8C/NDUFB11/MT-CO3/NDUFV3/VDAC1/SLC25A5/SLC2A1/NDUFV2/COX6B1/PPP1CB/MT-CO2/COX6C/COX7C/MT-CO1/INSR/NDUFA6/VDAC2/NDUFC1/PARP1/NDUFB4/NDUFV1/NDUFS7/AKT1/NDUFB3/UQCRC1/PRKCZ/NDUFB2/UQCRFS1/PTEN/NDUFS8/PDHA1	7.75614464036036
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	34/600	158/9376	3.36270042194093	CCNB1/YWHAE/CCNE1/PTTG1/SKP2/CDK7/CDC20/CCNB2/CDK1/MCM7/WEE1/MAD2L1/CCNA2/YWHAB/ORC6/ANAPC11/YWHAQ/CHEK1/SMC1A/CDT1/AURKB/CDC6/RAD21/NDC80/PKMYT1/CCND3/FBXO5/DBF4/CDCA5/PLK1/CDC45/MCM6/TRIP13/ESCO2	7.83126295080221
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	50/600	308/9376	2.53679653679654	TUBA1B/TUBA1C/TUBB/UQCRH/PSMA7/TUBB6/COX5B/COX5A/NDUFS5/TUBB4B/NDUFA4/PSMA4/PSMB2/COX8C/PSMB1/PSMB6/NDUFB11/MT-CO3/PSMB3/NDUFV3/VDAC1/PSMD11/SLC25A5/NDUFV2/COX6B1/MT-CO2/PPARG/COX6C/COX7C/PSMB5/PSMA1/MT-CO1/NDUFA6/ADRM1/POLR2H/PSMA3/POLR2I/VDAC2/NDUFC1/NDUFB4/NDUFV1/NDUFS7/NDUFB3/UQCRC1/NDUFB2/UQCRFS1/NDUFS8/PSMD4/PSMD12/TBPL1	7.17049160685877
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	58/600	388/9376	2.33594501718213	GAPDH/TUBA1B/TUBA1C/CALM1/CALM3/TUBB/UQCRH/PSMA7/TUBB6/COX5B/CTNNB1/COX5A/NDUFS5/TUBB4B/NDUFA4/PSMA4/HSD17B10/PSMB2/COX8C/PSMB1/PSMB6/NDUFB11/MT-CO3/SNCA/PSMB3/NDUFV3/VDAC1/PSMD11/SLC39A10/SLC25A5/NDUFV2/COX6B1/MT-CO2/APP/COX6C/COX7C/PSMB5/PSMA1/MT-CO1/INSR/NDUFA6/ADRM1/PSMA3/WNT7A/VDAC2/NDUFC1/NDUFB4/NDUFV1/NDUFS7/AKT1/NDUFB3/UQCRC1/HRAS/NDUFB2/UQCRFS1/NDUFS8/PSMD4/PSMD12	7.02725756157472
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	56/600	368/9376	2.37797101449275	TUBA1B/TUBA1C/TUBB/PFN1/ACTB/UQCRH/PSMA7/TUBB6/HSPA5/COX5B/COX5A/ALYREF/NDUFS5/TUBB4B/NDUFA4/PSMA4/HNRNPA3/ACTG1/PSMB2/COX8C/PSMB1/PSMB6/NDUFB11/MT-CO3/PSMB3/NDUFV3/VDAC1/PSMD11/NUP37/NDUFV2/COX6B1/MT-CO2/COX6C/COX7C/PSMB5/HNRNPA1/PSMA1/MT-CO1/NDUFA6/ADRM1/PSMA3/NDUFC1/CHCHD10/HNRNPA2B1/SRSF3/VCP/NDUFB4/NDUFV1/NDUFS7/NDUFB3/UQCRC1/NDUFB2/UQCRFS1/NDUFS8/PSMD4/PSMD12	7.05119554881664
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/600	138/9376	3.39710144927536	UQCRH/COX5B/COX5A/NDUFS5/PPA1/NDUFA4/COX8C/NDUFB11/MT-CO3/NDUFV3/ATP6V1F/NDUFV2/COX6B1/MT-CO2/COX6C/COX7C/ATP6V1B1/MT-CO1/NDUFA6/ATP6V1C2/NDUFC1/NDUFB4/NDUFV1/NDUFS7/NDUFB3/PPA2/UQCRC1/NDUFB2/UQCRFS1/NDUFS8	7.4173698532615
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	31/600	157/9376	3.08552016985138	LEP/UQCRH/CDC42/COX5B/COX5A/NDUFS5/NDUFA4/COX8C/NDUFB11/MT-CO3/NDUFV3/NDUFV2/COX6B1/MT-CO2/PPARG/COX6C/COX7C/MT-CO1/INSR/NDUFA6/NDUFC1/NDUFB4/PKLR/NDUFV1/NDUFS7/AKT1/NDUFB3/UQCRC1/NDUFB2/UQCRFS1/NDUFS8	6.89025459280503
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/600	227/9376	2.5470778267254	MGST1/UQCRH/MGST3/CYBA/COX5B/GRB2/COX5A/NDUFS5/NDUFA4/ACP1/COX8C/NDUFB11/MT-CO3/NDUFV3/VDAC1/SLC25A5/NDUFV2/COX6B1/MT-CO2/COX6C/COX7C/MT-CO1/GSTA4/NDUFA6/VDAC2/NDUFC1/NDUFB4/NDUFV1/NDUFS7/AKT1/NDUFB3/UQCRC1/HRAS/NDUFB2/UQCRFS1/PTEN/NDUFS8	6.16951795685599
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	37/600	235/9376	2.46036879432624	RPS6/ACTB/UQCRH/COX5B/GRB2/COX5A/NDUFS5/NDUFA4/ACTG1/COX8C/NDUFB11/MT-CO3/NDUFV3/COX20/NDUFV2/COX6B1/MT-CO2/PPARG/COX6C/COX7C/SMARCA2/MT-CO1/NDUFA6/GNAS/NDUFC1/NDUFAF4/NDUFB4/NDUFV1/NDUFS7/NDUFB3/UQCRC1/HRAS/NDUFB2/UQCRFS1/NDUFAF2/KDM1A/NDUFS8	5.92805981368747
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	60/600	480/9376	1.95333333333333	TUBA1B/TUBA1C/CALM1/CALM3/TUBB/UQCRH/RPS27A/PSMA7/TUBB6/HSPA5/COX5B/CTNNB1/COX5A/UBA52/NDUFS5/TUBB4B/NDUFA4/PSMA4/HSD17B10/PSMB2/COX8C/PSMB1/PSMB6/NDUFB11/UBE2L3/MT-CO3/SNCA/PSMB3/NDUFV3/VDAC1/PSMD11/SLC25A5/NDUFV2/COX6B1/MT-CO2/APP/COX6C/COX7C/PSMB5/PSMA1/MT-CO1/PARK7/NDUFA6/ADRM1/PSMA3/WNT7A/VDAC2/NDUFC1/VCP/NDUFB4/NDUFV1/NDUFS7/NDUFB3/UQCRC1/HRAS/NDUFB2/UQCRFS1/NDUFS8/PSMD4/PSMD12	5.60635980001022
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/600	46/9376	4.75594202898551	PSMA7/PSMA4/POMP/PSMB2/PSMB1/PSMB6/PSMB3/PSMD11/PSMB5/PSMA1/ADRM1/PSMA3/PSMD4/PSMD12	6.67682403320518
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	17/600	67/9376	3.96497512437811	GAPDH/LDHB/LDHA/TPI1/PGK1/ENO1/PKM/ADH5/PGAM1/PFKP/ALDOA/ALDH7A1/ALDH2/GPI/PKLR/ALDH1B1/PDHA1	6.36824695140292
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	21/600	116/9376	2.82896551724138	GAPDH/TPI1/PGK1/ENO1/PKM/TALDO1/TKT/ADH5/PGAM1/PFKP/GPT2/ALDOA/ACAT2/MDH1/PRPS2/MDH2/RPIA/GLDC/GPI/PKLR/PDHA1	5.18253179134696
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/600	75/9376	3.33368888888889	GAPDH/TPI1/PGK1/ENO1/PKM/TALDO1/CBS/TKT/PGAM1/PFKP/GPT2/ALDOA/PRPS2/ARG2/RPIA/PKLR	5.30544386861651
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/600	47/9376	3.98978723404255	LDHB/LDHA/PKM/ADH5/ACAT2/ALDH7A1/MDH1/ALDH2/MDH2/PKLR/ALDH1B1/PDHA1	5.37260140999685
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/600	87/9376	3.05348659003831	UQCRH/COX5B/COX5A/MYL4/TPM4/COX8C/MT-CO3/COX6B1/MT-CO2/COX6C/COX7C/MT-CO1/TPM3/UQCRC1/MYL3/UQCRFS1/ATP1B2	5.03129720137807
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	26/600	174/9376	2.33501915708812	CALR/PDIA6/TUSC3/OSTC/HSPA5/SSR2/LMAN1/SSR3/PDIA4/MAN1A2/HSP90AB1/PDIA3/SAR1A/P4HB/DAD1/DNAJC3/HSPA8/SEC61B/EDEM2/VCP/ERP29/LMAN2/HSP90B1/STT3B/DNAJB11/STT3A	4.6476558672802
Genetic Information Processing	Transcription	hsa03040	Spliceosome	32/600	243/9376	2.05783264746228	RBM8A/SNRPD2/ALYREF/SNRPB/SNRPD1/LSM5/SNRPF/HNRNPA3/SRSF9/LSM2/SNRPG/LSM4/LSM3/SNRPE/HNRNPC/U2AF1/SNRPA/SNRPD3/HNRNPA1/HNRNPM/HSPA8/LSM6/SRSF3/SRSF6/TXNL4A/THOC3/RBM25/TRA2A/MAGOH/SNRPA1/PPIH/SNRNP70	4.36843955060437
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/600	85/9376	2.94149019607843	RRM2/TYMS/ADA/TK1/NME1/HDDC2/DTYMK/PNP/AK5/RRM1/NT5DC4/DUT/DCTPP1/ADSL/ITPA/AK4	4.7013912073863
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	27/600	200/9376	2.1096	GAPDH/TUBA1B/TUBA1C/TUBB/RPS3/ACTB/TUBB6/TMBIM6/CDC42/CASP4/TUBB4B/MYO1B/ACTG1/ARPC3/NCL/CLDN6/ARPC5/CLDN10/TMED10/ACTR3/ARPC1A/EZR/ARPC4/CTTN/CLDN7/CLDN3/MYO10	4.14732146581001
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/600	138/9376	2.26473429951691	CALM1/CALM3/CCNB1/YWHAE/CCNE1/PTTG1/CDC20/CCNB2/PPP1CA/CDK1/MAD2L1/YWHAB/PPP1CB/ANAPC11/YWHAQ/SMC1A/AURKA/PKMYT1/FBXO5/PLK1	3.91347728251483
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/600	170/9376	2.11419607843137	TUBA1B/TUBA1C/ACTB/CDC42/ACTG1/ARPC3/CLDN6/JAM3/ACTN1/ARPC5/CLDN10/ACTR3/ACTN4/ARPC1A/EZR/MYL6/ARPC4/CTTN/CLDN7/CLDN3/MYL6B/MYL12A/PRKCZ	3.83321833757472
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/600	142/9376	2.20093896713615	CALM1/CALM3/GSTP1/ACTB/MGST1/MGST3/CYBA/MMP2/CTNNB1/TXN2/HSP90AB1/ACTG1/CDH5/GSTA4/RAC3/CAV1/HSP90B1/AKT1/PRKCZ/NPPC	3.77036269631802
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/600	59/9376	2.91344632768362	RRM2/GSTP1/ODC1/MGST1/PRDX6/MGST3/SRM/SMS/GSTA4/GGCT/RRM1	3.85493623675508
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/600	51/9376	3.0640522875817	ACTB/PDIA4/ACTG1/ATP6V1F/KDELR2/ATP6V1B1/SEC61B/ATP6V1C2/GNAS/KDELR1	3.86450896186441
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/600	36/9376	3.47259259259259	RPA3/SSBP1/MCM7/RNASEH2A/RNASEH2C/FEN1/MCM6/POLD3	3.88636272645472
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/600	144/9376	2.06185185185185	PSMA7/PSMA4/PSMB2/PSMB1/PSMB6/PSMB3/VDAC1/PSMD11/NOP56/SLC25A5/PSMB5/PSMA1/ADRM1/PSMA3/VDAC2/AKT1/PSMD4/PSMD12/TBPL1	3.35745525133541
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/600	157/9376	1.99065817409766	CALM1/CALM3/CCNB1/HLA-G/CCNE1/CCNB2/PPP1CA/CDK1/CCNA2/VDAC1/SLC25A5/PPP1CB/CHEK1/MYBL2/VDAC2/CCND3/AKT1/FOXM1/HRAS/PTEN	3.27299017897425
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/600	75/9376	2.50026666666667	CCNB1/RRM2/PERP/CCNE1/CCNB2/CDK1/CHEK1/SIVA1/GTSE1/EI24/CCND3/PTEN	3.41072909326234
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/600	116/9376	2.15540229885057	ACTB/CYBA/MMP2/CDC42/CTNNB1/ACTG1/CLDN6/JAM3/ACTN1/CLDN10/CDH5/ACTN4/EZR/CLDN7/CLDN3/MYL12A	3.27393222515206
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/600	31/9376	3.52860215053763	TALDO1/TKT/PFKP/ALDOA/PRPS2/RPIA/GPI	3.68709776385753
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/600	31/9376	3.52860215053763	SPCS3/SEC11A/SEC11C/HSPA5/SRP14/SEC61B/SRP72	3.68709776385753
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/600	78/9376	2.40410256410256	ENO1/HSPD1/LSM5/PFKP/LSM2/LSM4/LSM3/EXOSC5/LSM6/EXOSC8/EXOSC3/DCPS	3.25584947996576
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/600	78/9376	2.40410256410256	ACTB/CDC42/CTNNB1/ACTG1/ARPC3/CDH1/ARPC5/ACTR3/ARPC1A/CAV1/ARPC4/CTTN	3.25584947996576
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/600	59/9376	2.64858757062147	RRM2/TYMS/TK1/NME1/HDDC2/DTYMK/RRM1/NT5DC4/DUT/DCTPP1	3.32133693718298
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/600	50/9376	2.8128	ODC1/SRM/ALDH7A1/CKMT1A/SMS/ALDH2/ARG2/CKMT1B/ALDH1B1	3.36047094841323
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/600	110/9376	2.13090909090909	GAPDH/LDHB/LDHA/RPS6/PGK1/ENO1/PFKP/ALDOA/ANGPT4/SLC2A1/INSR/TF/AKT1/EIF4E/PDHA1	3.11954206331499
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/600	71/9376	2.42103286384977	LDHB/LDHA/SLC16A3/PKM/PGAM1/PFKP/SLC2A1/AKT1/HRAS/PTEN/PDHA1	3.14259245580597
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/600	93/9376	2.18437275985663	ACTB/CDC42/CTNNB1/ACTG1/ACP1/CDH1/ACTN1/CDH5/ACTN4/INSR/RAC3/MYL12A/ARHGAP29	3.00122575974031
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/600	44/9376	2.84121212121212	B4GALT1/TUSC3/OSTC/MAN1A2/ALG9/DAD1/STT3B/STT3A	3.20077948338113
Cellular Processes	Cell motility	hsa04814	Motor proteins	22/600	194/9376	1.77209621993127	TUBA1B/TUBA1C/TUBB/ACTB/TUBB6/MYL4/DYNLL1/TUBB4B/MYO1B/ACTG1/TPM4/CENPE/TPM3/MYL6/MYL6B/MYO10/MYL12A/TUBG1/KIF4A/MYL3/KIF14/KIF23	2.84129680567492
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/600	54/9376	2.60444444444444	LDHB/LDHA/CBS/SRM/AHCY/SMS/MDH1/MDH2/ADI1	3.09157630836705
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/600	56/9376	2.51142857142857	B4GALT1/TUSC3/OSTC/MAN1A2/SRD5A3/ALG9/DAD1/STT3B/STT3A	2.96610582057174
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	26/600	248/9376	1.63827956989247	GAPDH/TUBA1B/TUBA1C/TUBB/PFN1/RPS3/ACTB/TUBB6/CDC42/CTNNB1/CASP4/DYNLL1/TUBB4B/TXN2/ANXA2/HSP90AB1/ACTG1/ARPC3/ARPC5/ACTR3/ARPC1A/ARPC4/HSP90B1/MYL12A/AKT1/HRAS	2.66355656719421
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	24/600	224/9376	1.67428571428571	CALR/HLA-G/RAN/RANBP1/CCNE1/PTTG1/CDC20/CCNB2/FDPS/MAD2L1/CCNA2/VDAC1/SLC25A5/SLC2A1/ANAPC11/CHEK1/VDAC2/CCND3/AKT1/HRAS/TLN1/PTEN/MSX2/TBPL1	2.67068654337564
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/600	154/9376	1.82649350649351	GGH/ALAS2/NME1/MTHFD1L/HMBS/GCH1/DHFR/ALDH2/AK5/UGP2/AFMID/ALDH1B1/ALAS1/ALAD/ADSL/AK4/FECH/UROS	2.70395963041559
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/600	39/9376	2.80478632478632	TYMS/CBS/MTHFD1L/ALDH7A1/DHFR/AHCY/GLDC	2.95302668717471
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/600	41/9376	2.6679674796748	CBS/ALAS2/PGAM1/ALDH7A1/GLDC/GCAT/ALAS1	2.79856438083042
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/600	128/9376	1.83125	RRM2/ADA/PAICS/NME1/HDDC2/PRPS2/PDE4D/PNP/AK5/RRM1/NT5DC4/ADSL/ITPA/AK4/PPAT	2.47585774976303
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/600	46/9376	2.37797101449275	ALAS2/HMBS/BLVRB/ALAS1/ALAD/FECH/UROS	2.44957720742842
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/600	28/9376	2.79047619047619	ATP6V1F/CA2/ATP6V1B1/ATP6V1C2/SLC4A1	2.4808537922072
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	24/600	253/9376	1.48237154150198	PFN1/BNIP3/ACTB/RPS27A/CDC42/UBA52/CASP4/ACTG1/ARPC3/CBX3/VDAC1/ACTN1/ARPC5/U2AF1/ACTR3/ACTN4/ARPC1A/UBE2N/ARPC4/CTTN/PLCD4/MYL12A/AKT1/TLN1	2.03369610595413
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/600	20/9376	3.12533333333333	SQLE/EBP/MSMO1/FDFT1	2.48776813646385
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/600	203/9376	1.53957307060755	ACTB/PGF/CDC42/CTNNB1/GRB2/LAMA4/ACTG1/PPP1CA/ACTN1/PPP1CB/ACTN4/RAC3/CAV1/MYL12A/CCND3/AKT1/HRAS/TLN1/FLT4/PTEN	2.03214898559119
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/600	82/9376	1.90569105691057	RRM2/GSTP1/MGST1/MGST3/TK1/NME1/GSTA4/RRM1/DUT/ITPA	2.15376654973763
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/600	205/9376	1.52455284552846	HLA-G/RANBP1/PKM/YWHAE/CCNE1/CDC42/SKP2/GRB2/CDC20/CDK1/CCNA2/ACTN1/YWHAB/ACTN4/YWHAQ/CHEK1/GTF2A2/CCND3/HRAS/TBPL1	1.98550409536602
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/600	107/9376	1.75252336448598	LDHB/CALM1/CALM3/LDHA/PYGL/PKM/PGAM1/PFKP/SLC2A1/GNAS/AKT1/PDHA1	2.0469554577102
NA	NA	hsa04517	IgSF CAM signaling	27/600	299/9376	1.41110367892977	TUBA1B/TUBA1C/TUBB/ACTB/TUBB6/CDC42/CTNNB1/GRB2/DYNLL1/TUBB4B/ACTG1/ARPC3/JAM3/CDH1/ACTN1/ARPC5/PTPRS/ACTR3/ACTN4/ARPC1A/EZR/APP/MYL6/ARPC4/MYL6B/MYL12A/AKT1	1.88898602869428
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/600	31/9376	2.52043010752688	ACAT2/MDH1/MDH2/GLDC/AFMID	2.21702510550032
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/600	42/9376	2.23238095238095	ACAT2/ALDH7A1/ALDH2/AFMID/ALDH1B1/DHTKD1	2.0929009749403
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/600	212/9376	1.47421383647799	CALM1/CALM3/PFN1/ACTB/PGF/CDC42/CTNNB1/ID1/ACTG1/CDH1/ANGPT4/INSR/RALB/RAC3/GNAS/AKT1/HRAS/PRKCZ/TLN1/FLT4	1.82604959158324
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/600	76/9376	1.85052631578947	CALM1/CALM3/ACTB/ACTG1/CA2/EZR/GAST/GNAS/ATP1B2	1.94655210554463
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/600	138/9376	1.58531400966184	CALM1/CALM3/RPS6/PYGL/GRB2/PPP1CA/PPP1CB/INSR/PKLR/CBLB/AKT1/HRAS/PRKCZ/EIF4E	1.81114174006683
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/600	15/9376	3.12533333333333	ACP1/AK5/AK4	2.15389494336751
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/600	232/9376	1.41448275862069	PFN1/ACTB/CDC42/CFL1/ACTG1/PPP1CA/ARPC3/DIAPH3/ACTN1/ARPC5/ACTR3/PPP1CB/ACTN4/ARPC1A/EZR/RAC3/ARPC4/MYL12A/AKT1/HRAS/IQGAP3	1.67145738964258
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/600	36/9376	2.17037037037037	PYGL/GPI/UGP2/GYG2/GBE1	1.83956054757294
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/600	48/9376	1.95333333333333	HSD17B10/ACAT2/ALDH7A1/ALDH2/HMGCS1/ALDH1B1	1.73134686340969
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/600	37/9376	2.11171171171171	CTNNB1/CDH1/PPARG/TPM3/HRAS	1.77155977788925
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/600	110/9376	1.56266666666667	CCNB1/HSP90AB1/CCNB2/CDK1/MAD2L1/CCNA2/ANAPC11/AURKA/PKMYT1/AKT1/PLK1	1.55208084221953
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/600	50/9376	1.8752	HBA2/HBA1/GYPB/GYPA/CR1L/GYPC	1.62239859557108
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/600	137/9376	1.48282238442822	TUBA1B/TUBA1C/ACTB/BIRC5/ACTG1/LMNB1/CTSV/LMNB2/CASP6/PARP1/AKT1/HRAS/DFFA	1.48849764756374
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/600	28/9376	2.23238095238095	GGH/GCH1/DHFR/AKR1B1	1.70756638676389
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/600	63/9376	1.7362962962963	ACAT2/ALDH7A1/ALDH2/EZH2/PLOD1/ALDH1B1/DHTKD1	1.53317258614554
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/600	52/9376	1.80307692307692	CGA/CYP11A1/CYP19A1/INSR/GNAS/HSD3B1	1.51834562309477
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/600	89/9376	1.58022471910112	TUBA1B/TUBA1C/TUBB/TUBB6/GRB2/TUBB4B/CDK1/GNAS/HRAS	1.43802509040745
NA	NA	hsa04518	Integrin signaling	14/600	154/9376	1.42060606060606	ACTB/PGF/CDC42/CTNNB1/LAMA4/ACTG1/CDH1/ACTN1/ACTN4/RAC3/CCND3/AKT1/TLN1/FLT4	1.37605655610297
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/600	19/9376	2.46736842105263	GLDC/PDHA1/DHTKD1	1.67401987661431
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/600	155/9376	1.41144086021505	CALR/TUBA1B/TUBA1C/TUBB/HLA-G/ACTB/CYBA/TUBB6/TUBB4B/ACTG1/ATP6V1F/ATP6V1B1/SEC61B/ATP6V1C2	1.35050816273582
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/600	30/9376	2.08355555555556	ABCG2/TYMS/GGH/DHFR	1.55421779926733
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/600	157/9376	1.39346072186837	ACTB/YWHAE/CTNNB1/BIRC5/ID1/ACTG1/PPP1CA/CDH1/YWHAB/PPP1CB/YWHAQ/WNT7A/CCND3/PRKCZ	1.29993686233928
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/600	43/9376	1.81705426356589	ADH5/ACAT2/ALDH7A1/ALDH2/ALDH1B1	1.40406576947145
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/600	106/9376	1.47421383647799	GSTP1/CCNE1/CTNNB1/GRB2/HSP90AB1/HSP90B1/AKT1/HRAS/SPINT1/PTEN	1.28380848944323
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/600	32/9376	1.95333333333333	B4GALT1/PFKP/AKR1B1/UGP2	1.41242796863197
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/600	56/9376	1.67428571428571	BNIP3/HSPD1/SAR1A/HSPA8/VCP/CR1L	1.3232532583269
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/600	44/9376	1.77575757575758	CDK7/TAF9/GTF2A2/GTF2H5/TBPL1	1.34858385079916
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/600	44/9376	1.77575757575758	HMGB1/PARP1/FEN1/APEX1/POLD3	1.34858385079916
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/600	149/9376	1.36340044742729	NDUFS5/NDUFA4/NDUFB11/NDUFV3/NDUFV2/NDUFA6/NDUFC1/NDUFB4/NDUFV1/NDUFS7/NDUFB3/NDUFB2/NDUFS8	1.16912591620299
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/600	22/9376	2.13090909090909	ALDH7A1/ALDH2/ALDH1B1	1.38852373846273
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/600	59/9376	1.58915254237288	CTNNB1/GRB2/CDH1/AKT1/HRAS/PTEN	1.18693973889459
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/600	98/9376	1.43510204081633	CDC42/CFL1/ARPC3/ARPC5/ACTR3/ARPC1A/ARPC4/MYO10/AKT1	1.13211339827264
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/600	139/9376	1.34906474820144	CALM1/CALM3/MMP2/GRB2/KRT18/HSP90AB1/HSPA8/KRT23/GNAS/HSP90B1/AKT1/HRAS	1.0840788619678
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/600	23/9376	2.03826086956522	FDPS/ACAT2/HMGCS1	1.30349056921289
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/600	23/9376	2.03826086956522	RPA3/SSBP1/POLD3	1.30349056921289
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/600	23/9376	2.03826086956522	CA2/MDH1/ATP1B2	1.30349056921289
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/600	35/9376	1.78590476190476	TPI1/PFKP/ALDOA/AKR1B1	1.21792406690725
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/600	154/9376	1.3191341991342	CALM1/CALM3/MYL4/TPM4/PPP1CA/PPP1CB/TPM3/CREM/GNAS/ATP2B3/AKT1/MYL3/ATP1B2	1.04408078752481
NA	NA	hsa03272	Virion - Hepatitis viruses	5/600	48/9376	1.62777777777778	CLDN6/CLDN10/CLDN7/CLDN3/EPCAM	1.14010603476279
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/600	142/9376	1.32056338028169	RPS27A/UBE2C/SKP2/UBA52/CDC20/UBE2F/UBE2L3/ANAPC11/FBXW7/UBE2S/UBE2N/CBLB	1.00641268531898
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/600	13/9376	2.40410256410256	XRCC5/FEN1	1.32457316723103
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/600	75/9376	1.45848888888889	GSTP1/MGST1/MGST3/BIRC5/TOP2A/GSTA4/AKT1	1.04233562406962
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/600	37/9376	1.68936936936937	GPT2/NIT2/ADSL/PPAT	1.09853933714818
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/600	37/9376	1.68936936936937	GNPNAT1/GPI/UGP2/CMAS	1.09853933714818
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/600	63/9376	1.48825396825397	CDK7/RPA3/POLR2H/POLR2I/GTF2H5/POLD3	1.01667983795279
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/600	204/9376	1.22562091503268	RPS6/ACTB/MMP2/CDC42/CTNNB1/GRB2/ACTG1/PPP1CA/PPP1CB/EZR/ANK1/CAV1/WNT7A/CTTN/AKT1/HRAS	0.851874018927807
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/600	93/9376	1.344229390681	CGA/CALM1/CALM3/MMP2/CDC42/GRB2/GNAS/HRAS	0.872284596191319
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/600	93/9376	1.344229390681	CCNE1/SKP2/LAMA4/CKS2/AKT1/TRAF4/PTEN/CKS1B	0.872284596191319
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/600	27/9376	1.7362962962963	SCD/ELOVL6/TECR	1.00176273973279
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/600	109/9376	1.2902752293578	PYGL/PPP1CA/SLC2A1/PPP1CB/INSR/AKT1/PRKCZ/SLC27A6/PTEN	0.797015193541761
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/600	54/9376	1.44691358024691	RPA3/UBE2T/FANCD2/FANCE/FANCI	0.861150064349701
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/600	82/9376	1.3339837398374	CALR/HLA-G/HSPA2/HSPA5/HSP90AB1/PDIA3/HSPA8	0.794225582255132
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/600	70/9376	1.33942857142857	HLA-G/ACTB/ACTG1/CD55/RAC3/CAV1	0.745296099416923
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/600	170/9376	1.19498039215686	GSTP1/ACTB/MGST1/MGST3/CTNNB1/GRB2/ACTG1/SMARCA2/GSTA4/WNT7A/AKT1/HRAS/PTEN	0.670799717528561
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/600	156/9376	1.20205128205128	YWHAE/CTNNB1/GRB2/CLDN6/YWHAB/CLDN10/YWHAQ/CLDN7/CLDN3/AKT1/HRAS/EIF3E	0.665382547144341
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/600	30/9376	1.56266666666667	MDH1/MDH2/PDHA1	0.807071260817245
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/600	158/9376	1.18683544303797	RPS6/SKP2/GRB2/ATP6V1F/ATP6V1B1/INSR/ATP6V1C2/WNT7A/AKT1/HRAS/EIF4E/PTEN	0.619273382851492
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/600	217/9376	1.15219662058372	MGST1/MGST3/KPNA2/GRB2/BIRC5/HSP90AB1/PAQR7/GSTA4/CDC6/KPNB1/GNAS/HSP90B1/CCND3/AKT1/HRAS/PTGES3	0.593094371904266
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/600	31/9376	1.51225806451613	ALDH7A1/ALDH2/ALDH1B1	0.746952447143105
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/600	31/9376	1.51225806451613	ALDH7A1/ALDH2/ALDH1B1	0.746952447143105
NA	NA	hsa04981	Folate transport and metabolism	3/600	31/9376	1.51225806451613	ABCG2/TYMS/DHFR	0.746952447143105
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/600	87/9376	1.25731800766284	CTNNB1/GRB2/BIRC5/RALB/RAC3/AKT1/HRAS	0.630461079268138
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/600	133/9376	1.1749373433584	CCNB1/BNIP3/SKP2/GRB2/CCNB2/INSR/AKT1/HRAS/PLK1/PTEN	0.531269430372673
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/600	75/9376	1.25013333333333	CGA/HSPA5/PDIA4/GNAS/HSP90B1/ATP1B2	0.568656930231083
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/600	61/9376	1.28087431693989	MT1E/SLC6A19/ATP2B3/TF/ATP1B2	0.575437914414371
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/600	134/9376	1.16616915422886	CALM1/CALM3/PPP1CA/PPP1CB/PLA2G2A/MYL6/GNAS/MYL6B/PLA2G10/NPPC	0.506562203805858
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/600	47/9376	1.32992907801418	PKM/INSR/PKLR/PRKCZ	0.592877449456906
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/600	33/9376	1.42060606060606	GPT2/PDHA1/DHTKD1	0.632852176211911
NA	NA	hsa04519	Cadherin signaling	28/600	404/9376	1.08303630363036	ACTB/YWHAE/DSC2/CDC42/CTNNB1/MYO1B/KRT18/ACTG1/PPP1CA/ARPC3/CDH1/DSP/ACTN1/ARPC5/YWHAB/ACTR3/PPP1CB/CDH5/ACTN4/ARPC1A/YWHAQ/RAC3/WNT7A/ARPC4/KRT23/TMC6/HRAS/FLT4	0.44609464967872
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/600	105/9376	1.19060317460317	BNIP3/RPS27A/UBA52/TOMM20/PHB2/CITED2/VCP/HRAS	0.513540198804369
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/600	76/9376	1.23368421052632	SCD/PLTP/PPARG/DBI/HMGCS1/SLC27A6	0.534820009196669
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/600	76/9376	1.23368421052632	CALM1/CALM3/GRB2/AKT1/HRAS/PTEN	0.534820009196669
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/600	20/9376	1.56266666666667	UGP2/CMAS	0.658618665989803
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/600	34/9376	1.37882352941176	POLR1D/POLR2H/POLR2I	0.578588009407075
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/600	166/9376	1.12963855421687	CALM1/CALM3/PPP1CA/VDAC1/SLC25A5/PPP1CB/INSR/VDAC2/ATP2B3/AKT1/NPPC/ATP1B2	0.440627262155207
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/600	122/9376	1.1527868852459	ACTB/CTNNB1/PFKP/ACTG1/SLC2A1/PLCD4/AKT1/HRAS/ATP1B2	0.444134184088386
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/600	108/9376	1.15753086419753	RAN/RBM8A/KPNA2/ALYREF/NUP37/KPNB1/THOC3/MAGOH	0.430524109189246
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/600	138/9376	1.13236714975845	ACTB/CDC42/ACTG1/ARPC3/ARPC5/ACTR3/ARPC1A/RAC3/ARPC4/AKT1	0.409584711768168
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/600	21/9376	1.48825396825397	CHSY1/DSEL	0.585661248845486
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/600	21/9376	1.48825396825397	ALDH2/ALDH1B1	0.585661248845486
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/600	214/9376	1.09532710280374	CALR/CALM1/CALM3/CCNB1/HLA-G/CFL1/CCNB2/CDK1/WEE1/PDIA3/CHEK1/AP1M2/RAC3/AKT1/HRAS	0.36884261562963
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/600	65/9376	1.20205128205128	ALDH7A1/AKR1B1/ALDH2/AGPAT5/ALDH1B1	0.427398586543793
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/600	80/9376	1.172	RPS6/GRB2/AKT1/HRAS/EIF4E/PTEN	0.40395997717466
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/600	216/9376	1.08518518518519	CALM1/CALM3/CYBA/HSPA2/HSPA5/CDC42/HSPD1/HSP90AB1/PPARG/CASP6/HSPA8/HSP90B1/AKT1/CCL3L1/HRAS	0.331173948984829
Organismal Systems	Immune system	hsa04611	Platelet activation	9/600	126/9376	1.11619047619048	ACTB/ACTG1/PPP1CA/PPP1CB/GNAS/MYL12A/AKT1/PRKCZ/TLN1	0.343319043507059
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/600	37/9376	1.26702702702703	HBA2/HBA1/LAMA4	0.42551889640711
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/600	67/9376	1.16616915422886	CALM1/CALM3/PPP1CA/PPP1CB/HRAS	0.356902221922373
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/600	23/9376	1.35884057971014	GPT2/ARG2	0.450508465853031
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/600	98/9376	1.11619047619048	CALM1/CALM3/CYP11A1/GNAS/ATP2B3/HSD3B1/ATP1B2	0.302321714235408
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/600	38/9376	1.23368421052632	GNPNAT1/GPI/UGP2	0.37740459958033
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/600	53/9376	1.17937106918239	RAB11A/GNAS/ATP2B3/ATP1B2	0.34239344814212
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/600	69/9376	1.13236714975845	CALM1/CALM3/PPP1CA/PPP1CB/GNAS	0.288544540746077
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/600	70/9376	1.11619047619048	CDC42/GRB2/SLC2A1/AKT1/HRAS	0.255123805075378
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/600	71/9376	1.10046948356808	CDC42/JAM3/ATP6V1F/ATP6V1B1/ATP6V1C2	0.222186727085528
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/600	102/9376	1.07241830065359	RAB11A/CA2/PLA2G2A/GNAS/PLA2G10/ATP2B3/ATP1B2	0.192277216209416
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/600	41/9376	1.14341463414634	RPA3/SSBP1/POLD3	0.240625247016224
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/600	41/9376	1.14341463414634	MMP2/CDH1/HRAS	0.240625247016224
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/600	57/9376	1.0966081871345	ACAT2/SCD/ELOVL6/TECR	0.191284447406679
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/600	26/9376	1.20205128205128	PLA2G2A/PLA2G10	0.269746261966153
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/600	73/9376	1.0703196347032	GSTP1/MGST1/MGST3/ADH5/GSTA4	0.157702828115598
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/600	27/9376	1.15753086419753	ACAT2/HMGCS1	0.214327507696015
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/600	43/9376	1.09023255813953	ACAT2/PLA2G2A/PLA2G10	0.155060014768954
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/600	59/9376	1.05943502824859	CGA/INSR/GNAS/AKT1	0.119741139750394
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/600	154/9376	1.01471861471861	CALM1/CALM3/ACTB/ACTG1/PPP1CA/PPP1CB/MYL6/GNAS/MYL6B/HRAS	0.0481534817903468
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	15/600	233/9376	1.00600858369099	ACTB/ENO1/DSC2/MYL4/ACTG1/TPM4/LMNB1/DIAPH3/DSP/LMNB2/TPM3/CSRP1/MYL3/TLN1/ATP1B2	0.0242839131731975
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/600	60/9376	1.04177777777778	CDC42/RAC3/AKT1/HRAS	0.0848826983277319
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/600	44/9376	1.06545454545455	RAB11A/DYNLL1/GNAS	0.113786762411179
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/600	28/9376	1.11619047619048	ELOVL6/TECR	0.160991575877276
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/600	77/9376	1.01471861471861	RALBP1/CDC42/RALB/RAC3/AKT1	0.0339083870645346
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/600	333/9376	0.985465465465465	HLA-G/PKM/CCNE1/CDC42/CTNNB1/GRB2/LAMA4/CCNA2/ATP6V1F/HEY1/ATP6V1B1/ATP6V1C2/WNT7A/GNAS/TUBG1/CCND3/AKT1/HRAS/PRKCZ/PTEN/TBPL1	-0.0706122313728144
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/600	29/9376	1.07770114942529	CALM1/CALM3	0.10957293053452
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/600	238/9376	0.984873949579832	CALM1/CALM3/PGF/RALBP1/CDC42/GRB2/ANGPT4/PLA2G2A/INSR/RALB/RAC3/PLA2G10/AKT1/HRAS/FLT4	-0.0618018394507975
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/600	62/9376	1.00817204301075	INSR/HSPA8/AKT1/HRAS	0.0168799566819335
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/600	79/9376	0.989029535864979	GSTP1/MGST1/MGST3/ADH5/GSTA4	-0.0256023652022303
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/600	63/9376	0.992169312169312	PTGDS/PLA2G2A/PLA2G10/PTGES3	-0.0163056584327064
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/600	30/9376	1.04177777777778	PLA2G2A/PLA2G10	0.0599247223671572
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/600	14/9376	1.11619047619048	B4GALT1	0.11375308592696
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/600	180/9376	0.954962962962963	CALR/HLA-G/ALYREF/SRSF9/PPP1CA/PDIA3/PPP1CB/SRSF3/SRSF6/AKT1/EIF2B2	-0.15952161512611
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/600	32/9376	0.976666666666667	LDHB/LDHA	-0.0345699153161671
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/600	66/9376	0.947070707070707	CYP11A1/SRD5A3/CYP19A1/HSD3B1	-0.112825216555941
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/600	101/9376	0.928316831683168	CALM1/CALM3/CTNNB1/WNT7A/GNAS/HRAS	-0.189379897112867
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/600	101/9376	0.928316831683168	MMP2/CDC42/PLCD4/AKT1/HRAS/PRKCZ	-0.189379897112867
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/600	68/9376	0.91921568627451	GRB2/CCNA2/AKT1/HRAS	-0.174809996892396
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/600	250/9376	0.9376	HLA-G/RAB11A/CDC42/ARPC3/ARPC5/ACTR3/ARPC1A/HSPA8/CAV1/ARPC4/CBLB/CHMP2A/HRAS/PRKCZ/SNX2	-0.261473281846189
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/600	51/9376	0.91921568627451	PLA2G2A/PLA2G10/PAFAH1B3	-0.151251839039405
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/600	86/9376	0.908527131782946	ACTB/DSC2/CTNNB1/ACTG1/DSP	-0.222816127362688
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/600	69/9376	0.905893719806763	GRB2/RAC3/AKT1/HRAS	-0.205140425318744
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/600	103/9376	0.910291262135922	RBM8A/ALYREF/PPP1CA/PPP1CB/PAPOLA/MAGOH	-0.23936254019384
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/600	16/9376	0.976666666666667	MIF	-0.0244237197699759
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/600	120/9376	0.911555555555556	CALM1/CALM3/YWHAE/CDC42/GRB2/AKT1/HRAS	-0.254954372432826
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/600	52/9376	0.901538461538462	VDAC1/PLTP/VDAC2	-0.186157317774072
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/600	70/9376	0.892952380952381	GSTP1/MGST1/MGST3/GSTA4	-0.235048489266168
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/600	205/9376	0.914731707317073	CALR/HLA-G/CCNE1/SKP2/PDIA3/CCNA2/PSMD11/ADRM1/CCND3/AKT1/PSMD4/PSMD12	-0.322752122631723
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/600	105/9376	0.892952380952381	ACTB/ACTG1/TPM4/TPM3/GNAS/MYL3	-0.288417313519043
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/600	122/9376	0.896612021857924	LEP/PFKP/SCD/CCNA2/PPARG/INSR/AKT1	-0.300537151750796
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/600	71/9376	0.88037558685446	CGA/GRB2/AKT1/HRAS	-0.264547561034545
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/600	17/9376	0.91921568627451	CA2	-0.0871665250890868
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/600	173/9376	0.903275529865125	ACTB/RAB11A/KPNA2/ACTG1/FDPS/VDAC1/SLC25A5/DNAJC3/CCND3/AKT1	-0.335743532842392
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/600	36/9376	0.868148148148148	AKR1B1/UGP2	-0.20724163130885
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/600	36/9376	0.868148148148148	GALNT2/ST6GALNAC1	-0.20724163130885
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/600	140/9376	0.892952380952381	CALM1/CALM3/RPS6/MYL4/CDH1/AKT1/HRAS/MYL3	-0.333666052974269
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/600	90/9376	0.868148148148148	PPARG/INSR/AKT1/HRAS/EIF4E	-0.328629166241075
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/600	90/9376	0.868148148148148	ABCG2/CA2/SLC2A1/GNAS/ATP1B2	-0.328629166241075
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/600	37/9376	0.844684684684685	ADH5/MIF	-0.24750154433396
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/600	73/9376	0.856255707762557	CDH1/AKT1/HRAS/PTEN	-0.322369157732405
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/600	160/9376	0.879	HLA-G/CLDN6/JAM3/CDH1/PTPRS/CLDN10/CDH5/CLDN7/CLDN3	-0.403633389318674
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/600	38/9376	0.822456140350877	PNP/NT5DC4	-0.28673682790938
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/600	38/9376	0.822456140350877	INSR/ATP1B2	-0.28673682790938
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/600	144/9376	0.868148148148148	CTNNB1/ADH5/ALDH7A1/SCD/ALDH2/TRA2A/AKT1/ALDH1B1	-0.416900617187097
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/600	93/9376	0.840143369175627	CALM1/CALM3/GNAS/ATP2B3/ATP1B2	-0.405080101938076
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/600	148/9376	0.844684684684685	CTNNB1/GRB2/HEY1/WNT7A/AKT1/HRAS/FLT4/PTEN	-0.497971288720238
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/600	78/9376	0.801367521367521	TPI1/PLCD4/PTEN/ITPKB	-0.460591319177041
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/600	42/9376	0.744126984126984	VDAC2/TF	-0.434538430139587
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/600	98/9376	0.797278911564626	CALM1/CALM3/PLCD4/PTEN/ITPKB	-0.527469969801824
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/600	99/9376	0.789225589225589	MMP2/GRB2/GNAS/AKT1/HRAS	-0.551244994570711
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/600	99/9376	0.789225589225589	CALM1/CALM3/PPP1CA/PPP1CB/GNAS	-0.551244994570711
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/600	99/9376	0.789225589225589	ACTB/ACTG1/TPM4/TPM3/MYL3	-0.551244994570711
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/600	23/9376	0.679420289855072	B4GALT1	-0.402473637506828
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/600	44/9376	0.71030303030303	HLA-G/HSPD1	-0.503611781782811
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	20/600	362/9376	0.863351749539595	RPS6/PGF/YWHAE/CCNE1/GRB2/LAMA4/HSP90AB1/YWHAB/ANGPT4/YWHAQ/INSR/HSP90B1/CCND3/AKT1/HRAS/GH2/CDC37/FLT4/EIF4E/PTEN	-0.693286175465812
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/600	83/9376	0.753092369477912	CBX3/AURKB/EZH2/WDR5	-0.590756549853044
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/600	45/9376	0.694518518518519	ABCG2/ABCA7	-0.537081269017321
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/600	227/9376	0.826079295154185	CALR/CALM1/CALM3/HLA-G/CTNNB1/GRB2/PDIA3/RAC3/GNAS/AKT1/CCL3L1/HRAS	-0.693570092647808
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/600	65/9376	0.721230769230769	CYP11A1/GNAS/HSD3B1	-0.589679877272096
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/600	65/9376	0.721230769230769	CGA/AKT1/HRAS	-0.589679877272096
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/600	157/9376	0.796263269639066	CALR/ODC1/SLC2A1/PPARG/ARG2/DUSP5/SLC16A1/UQCRFS1	-0.673116454295691
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/600	24/9376	0.651111111111111	HS3ST1	-0.447459225433546
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/600	103/9376	0.758576051779935	LAMA4/ACTN1/ACTN4/ARG2/GNAS	-0.644171915528878
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/600	195/9376	0.801367521367521	ACTB/HMGB1/CYBA/CASP4/ACTG1/VDAC1/SLC25A5/VDAC2/AKT1/CR1L	-0.732884488699278
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/600	86/9376	0.726821705426357	GRB2/CBLB/AKT1/HRAS	-0.665427146462808
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/600	105/9376	0.744126984126984	CALM1/CALM3/CBLB/AKT1/HRAS	-0.689396069680749
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/600	125/9376	0.75008	RAC3/AKT1/HRAS/PRKCZ/ORMDL2/PTEN	-0.735486379346581
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/600	26/9376	0.601025641025641	PKLR	-0.532646172105754
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/600	48/9376	0.651111111111111	AKT1/ATP1B2	-0.633616451177905
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/600	144/9376	0.75962962962963	CTNNB1/GRB2/ID1/WNT7A/DLX5/AKT1/HRAS	-0.76002387796187
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/600	88/9376	0.71030303030303	TFPI/PROCR/CD55/CR1L	-0.713899604264378
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/600	69/9376	0.679420289855072	CALM1/CALM3/GNAS	-0.698825391383565
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/600	163/9376	0.766952965235174	CCNE1/GRB2/BIRC5/CCNA2/YWHAB/YWHAQ/AKT1/HRAS	-0.784783392853853
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/600	49/9376	0.637823129251701	B4GALT1/GALNT2	-0.664600585879415
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/600	70/9376	0.669714285714286	LEP/SLC2A1/AKT1	-0.725220783607714
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/600	91/9376	0.686886446886447	GRB2/RAC3/AKT1/HRAS	-0.784773924991592
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/600	28/9376	0.558095238095238	B4GALT1	-0.612295829566032
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/600	130/9376	0.721230769230769	MMP2/GRB2/GNAS/AKT1/HRAS/PRKCZ	-0.836859449550353
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/600	149/9376	0.73413870246085	GRB2/INSR/RALB/AGPAT5/GNAS/AKT1/HRAS	-0.855324574498668
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/600	168/9376	0.744126984126984	HMGB1/PYGL/HSP90AB1/VDAC1/SLC25A5/VDAC2/PARP1/CHMP2A	-0.875002773633723
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/600	150/9376	0.729244444444444	CCNE1/CTNNB1/GRB2/CDH1/WNT7A/AKT1/HRAS	-0.874035831402987
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/600	187/9376	0.752085561497326	CYBA/YWHAE/CASP4/TXN2/HSP90AB1/VDAC1/SUGT1/VDAC2/TRIP6	-0.895367763958745
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/600	73/9376	0.642191780821918	GRB2/AKT1/HRAS	-0.802441143580408
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/600	133/9376	0.704962406015038	CALM1/CALM3/PPP1CA/PPP1CB/GNAS/AKT1	-0.896003400336263
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/600	226/9376	0.760589970501475	CGA/CALM1/CALM3/PPP1CA/PPP1CB/RAC3/PDE4D/GNAS/ATP2B3/AKT1/ATP1B2	-0.952574538050784
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/600	95/9376	0.657964912280702	ATP6V1F/ATP6V1B1/ATP6V1C2/CCL3L1	-0.876088607576827
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/600	115/9376	0.679420289855072	NACA/GCM1/MMP15/PDE4D/GNAS	-0.904417518652289
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/600	54/9376	0.578765432098765	CGA/HLA-G	-0.81166961866331
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/600	155/9376	0.705720430107527	CCNE1/CTNNB1/CYP11A1/WNT7A/GNAS/HSD3B1/WDR5	-0.96593945739478
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/600	136/9376	0.689411764705882	CCNE1/EIF3H/HSPA8/CBLB/CCND3/AKT1	-0.953962769727687
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/600	117/9376	0.667806267806268	ACTB/ACTG1/SMARCA2/RUVBL1/INO80C	-0.9453993054132
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/600	77/9376	0.608831168831169	GRB2/AKT1/HRAS	-0.901165251515102
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/600	32/9376	0.488333333333333	BIRC5	-0.758068857290238
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/600	78/9376	0.601025641025641	CALM1/CALM3/CFL1	-0.92514641906989
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/600	99/9376	0.631380471380471	GRB2/RAC3/AKT1/HRAS	-0.96406233235785
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/600	33/9376	0.473535353535354	VTI1B	-0.792129092799347
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/600	79/9376	0.593417721518987	ATP6V1F/ATP6V1B1/ATP6V1C2	-0.948863042648804
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/600	34/9376	0.459607843137255	NFIL3	-0.825356394371583
NA	NA	hsa04382	Cornified envelope formation	10/600	217/9376	0.720122887864823	S100A11/PADI1/KRT18/CLDN6/DSP/CLDN10/KRT23/CLDN7/CLDN3/TCHH	-1.09065194348968
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/600	122/9376	0.640437158469945	CDC42/GRB2/CBLB/AKT1/HRAS	-1.04520848758998
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/600	122/9376	0.640437158469945	GRB2/GNAS/AKT1/HRAS/GH2	-1.04520848758998
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/600	143/9376	0.655664335664336	SNRPB/SNRPD1/ACTN1/ACTN4/SSB/SNRPD3	-1.08490463307921
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/600	103/9376	0.606860841423948	CALR/GNAS/AKT1/CCL3L1	-1.04898129086392
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/600	60/9376	0.520888888888889	GNAS/HRAS	-0.973442008481862
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/600	183/9376	0.683132969034608	RAN/NHP2/NOP56/POP7/FBL/RRP7A/EMG1/IMP4	-1.13184491867449
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/600	63/9376	0.496084656084656	CTNNB1/WNT7A	-1.04929115481821
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/600	38/9376	0.411228070175439	ADA	-0.950878255399091
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/600	86/9376	0.545116279069767	SLC2A1/GNAS/ATP1B2	-1.10803816556293
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/600	169/9376	0.647258382642998	BNIP3/HMGB1/RPS27A/UBA52/AKT1/HRAS/PTEN	-1.20991243066933
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/600	39/9376	0.400683760683761	HLA-G	-0.980612953706622
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/600	110/9376	0.568242424242424	ID1/LRRC32/TF/GREM2	-1.19097629469753
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/600	191/9376	0.654520069808028	CALM1/CALM3/GRB2/PPP1CA/PPP1CB/GNAS/SLC29A1/HRAS	-1.26128398853696
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/600	193/9376	0.647737478411054	CDC42/GRB2/CCR7/RAC3/AKT1/CCL3L1/HRAS/PRKCZ	-1.29290244879515
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/600	90/9376	0.520888888888889	AKT1/HRAS/PTEN	-1.19414238609397
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/600	254/9376	0.676745406824147	CALM1/CALM3/VDAC1/SLC25A5/GNAS/VDAC2/PLCD4/ATP2B3/FLT4/ITPKB/MST1	-1.36561879400103
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/600	196/9376	0.637823129251701	CALM1/CALM3/HLA-G/RPS27A/CTNNB1/UBA52/AKT1/HRAS	-1.33980120248977
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/600	178/9376	0.614531835205993	CTNNB1/LGR4/RAC3/CACYBP/WNT7A/RUVBL1/CCND3	-1.35757793540704
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/600	94/9376	0.498723404255319	HSP90AB1/HSP90B1/TRAF4	-1.27712536069612
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/600	45/9376	0.347259259259259	HLA-G	-1.14761400159569
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/600	97/9376	0.483298969072165	CALM1/CALM3/GNAS	-1.33748082354586
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/600	184/9376	0.594492753623188	CDC42/CFL1/RAC3/MYL12A/HRAS/PRKCZ/SEMA6A	-1.45249778637163
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/600	100/9376	0.4688	GYPA/CD55/CR1L	-1.39633830671775
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/600	49/9376	0.31891156462585	GNAS	-1.24980861491824
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/600	168/9376	0.558095238095238	LEP/GRB2/CCND3/AKT1/HRAS/GH2	-1.51117104329794
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/600	78/9376	0.400683760683761	CYBA/CR1L	-1.38970151896274
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/600	104/9376	0.450769230769231	PLA2G2A/AGPAT5/PLA2G10	-1.47264400496168
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/600	83/9376	0.376546184738956	POLR1D/POLR2H	-1.49168911514617
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/600	300/9376	0.625066666666667	PGF/CDC42/GRB2/STMN1/ANGPT4/INSR/RAC3/HSPA8/AKT1/DUSP5/HRAS/FLT4	-1.72575997699132
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/600	133/9376	0.469974937343358	HLA-G/GRB2/RAC3/HRAS	-1.60963981569073
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/600	201/9376	0.544212271973466	MYCN/CCNA2/PPARG/ETV4/SPINT1/TLX3/LMO2	-1.70793200192351
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/600	112/9376	0.418571428571429	LAMA4/HSPA8/AKT1	-1.6185237011736
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/600	89/9376	0.351161048689139	LAMA4/HMMR	-1.60807814783235
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/600	115/9376	0.407652173913043	APP/GNAS/HRAS	-1.67112806611014
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/600	91/9376	0.343443223443223	PDE4D/GNAS	-1.64556479077554
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/600	142/9376	0.44018779342723	CYBA/GRB2/PPARG/AKT1	-1.75753732568007
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/600	62/9376	0.252043010752688	HEY1	-1.54496024578328
NA	NA	hsa04081	Hormone signaling	7/600	219/9376	0.499482496194825	CGA/LEP/INSR/GAST/GNAS/GH2/NPPC	-1.95964623029444
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/600	68/9376	0.229803921568627	ADH5	-1.66663511600323
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/600	99/9376	0.315690235690236	KRT18/KRT23	-1.78969700793213
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/600	100/9376	0.312533333333333	CCR7/CCL3L1	-1.8071085114048
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/600	103/9376	0.303430420711974	SLC6A19/ATP1B2	-1.85860004153399
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/600	181/9376	0.431675874769797	CALM1/CALM3/HSPD1/AKT1/CR1L	-2.01870318809188
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/600	73/9376	0.214063926940639	RAN	-1.76258511527641
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/600	109/9376	0.286727828746177	AKT1/CCL3L1	-1.95844736348167
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/600	115/9376	0.271768115942029	AKT1/HRAS	-2.05448333983907
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/600	250/9376	0.437546666666667	CTSV/CTSE/ATP6V1F/ATP6V1B1/AP1M2/ATP6V1C2/SLC29A1	-2.35683523961531
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/600	89/9376	0.175580524344569	SLC38A5	-2.04323575329518
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/600	323/9376	0.483797729618163	CCNE1/GRB2/STMN1/EZR/IGF2BP1/EZH2/CDCA5/HRAS/PTEN/KIF23	-2.46852691854541
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/600	105/9376	0.148825396825397	PARP1	-2.29331109432757
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/600	109/9376	0.143363914373089	HSP90AB1	-2.35208487162788
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/600	116/9376	0.134712643678161	GNAS	-2.45186647343262
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/600	119/9376	0.131316526610644	AKT1	-2.49352004692064
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/600	298/9376	0.209753914988814	LEP/CCR7/CCL3L1/GH2	-3.62483591255979
NA	NA	hsa04082	Neuroactive ligand signaling	1/600	199/9376	0.0785259631490787	GNAS	-3.43535981854508
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/600	370/9376	0.211171171171171	CGA/LEP/GAL/TMEM97/GH2	-4.04790788393183
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/600	449/9376	0.0696065330363771	CALM1/CALM3	-5.28262778665052