category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/279	233/9376	3.89422677557801	COL1A1/COL3A1/ENO1/COL6A2/DSP/ACTB/SPTBN1/DCN/COL6A3/DSC2/VCAN/LMNB2/COL1A2/ACTG1/DIAPH3/TPM2/TPM4/LMNB1/MYL4/ATP1B3/PLEC/COL6A1/TLN1/COL27A1/VCL/COL5A2/SGCB	7.8343830184469
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/279	174/9376	3.86272813414082	CALR/HSPA5/PDIA6/HSP90B1/LMAN1/HSP90AB1/MAN1A2/HSP90AA1/PDIA3/SSR3/SSR2/PDIA4/HSPA8/OSTC/DNAJC3/RRBP1/SEC61A1/STT3B/DAD1/SAR1A	6.67501518966947
NA	NA	hsa04518	Integrin signaling	18/279	154/9376	3.92794302471722	COL1A1/COL6A2/ACTB/PGF/COL6A3/ACTN4/ACTN1/FLNB/LAMA4/COL1A2/ACTG1/CTNNB1/IGF1/COL6A1/FERMT2/TLN1/VCL/LAMB1	6.41577412110306
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/279	203/9376	3.14536433780038	COL1A1/COL6A2/ACTB/PGF/CAV1/COL6A3/ACTN4/ACTN1/FLNB/LAMA4/COL1A2/ACTG1/CTNNB1/GRB2/IGF1/COL6A1/TLN1/VCL/LAMB1	5.41167892252025
Genetic Information Processing	Transcription	hsa03040	Spliceosome	20/279	243/9376	2.76590409605145	SRSF7/RBM8A/SRSF3/HNRNPA3/HNRNPC/HSPA8/SNRPB/FUS/RBM25/U2AF1/SRSF2/SRSF6/HNRNPU/SNRPF/U2SURP/LSM4/SNRPD1/DDX5/TRA2A/DDX39B	4.88429812579909
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/279	103/9376	3.91523123499321	COL1A1/COL3A1/COL6A2/COL6A3/COL1A2/ATP1B3/COL6A1/SLC6A19/COL27A1/SLC38A2/COL18A1/COL5A2	5.20978898845152
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/279	200/9376	2.85648745519713	TUBA1B/TUBB/TUBA1C/TMBIM6/GAPDH/TUBB4B/ACTB/NCL/EZR/TUBB6/CLDN10/ACTG1/CLDN4/TMED10/MYO10/MYO1B/CASP4	4.64749527374672
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/279	116/9376	3.47645532072673	ACTB/JAM3/CYBA/EZR/ACTN4/ACTN1/CLDN10/ACTG1/CTNNB1/CLDN4/THY1/VCL	4.69994353934216
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/279	155/9376	3.03535668863452	CALR/TUBA1B/HLA-G/TUBB/TUBA1C/HLA-C/TUBB4B/ACTB/C1R/CYBA/TUBB6/ACTG1/EEA1/SEC61A1	4.47461845265215
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	14/279	158/9376	2.97772333378703	CCNB1/PTTG1/SMC1A/CCNE1/PRKDC/CDC20/RAD21/SKP2/BUB3/CCNB2/CCNA2/WEE1/SMC3/AURKB	4.39050394353453
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/279	142/9376	3.07658135191075	MGST1/HSP90B1/CALM1/ACTB/CAV1/CYBA/HSP90AB1/HSP90AA1/CALM3/MGST3/ACTG1/CTNNB1/BMP4	4.36653382982917
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/279	75/9376	4.03268817204301	ENO1/GAPDH/TPI1/PKM/GPT2/CBS/PGK1/PHGDH/PRPS2	4.61776905881505
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/279	268/9376	2.38249612154282	TUBA1B/HSPA5/TUBB/TUBA1C/TUBB4B/CALM1/NDUFA4/CALM3/MT-CO3/TUBB6/PSMA7/UQCRH/SNCA/MT-CO1/SLC39A10/NDUFV3/MT-CO2/PSMB2/PSMB1	4.02122570580374
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	24/279	388/9376	2.07870524332114	TUBA1B/TUBB/TUBA1C/GAPDH/TUBB4B/CALM1/NDUFA4/CALM3/MT-CO3/TUBB6/PSMA7/UQCRH/SNCA/MT-CO1/CTNNB1/DKK1/SLC39A10/NDUFV3/MT-CO2/PSMB2/WNT2/ATP2A2/INSR/PSMB1	3.80036896755339
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	23/279	368/9376	2.10035842293907	TUBA1B/HSPA5/TUBB/TUBA1C/TUBB4B/ACTB/NDUFA4/HNRNPA2B1/SRSF7/MT-CO3/TUBB6/PSMA7/UQCRH/SRSF3/HNRNPA3/ACTG1/MT-CO1/FUS/NDUFV3/MT-CO2/PSMB2/NUP37/PSMB1	3.77122579087165
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/279	82/9376	3.68843430369788	CALR/HSPA5/HLA-G/HLA-C/HSPA2/HSP90AB1/HSP90AA1/PDIA3/HSPA8	4.28197041999037
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/279	67/9376	4.01262504680897	LDHA/ENO1/GAPDH/LDHB/TPI1/PKM/PGK1/ADH5	4.33380744340732
Genetic Information Processing	Translation	hsa03010	Ribosome	16/279	222/9376	2.42203493816397	RPS4X/RPL29/RPL7A/RPL22L1/RPS3A/RPSA/RPL36/RPS18/MRPS15/RPL5/RPS15/MRPL11/RPL19/MRPL51/RPL14/RPS5	3.75508647243859
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/279	87/9376	3.47645532072673	MT-CO3/UQCRH/TPM2/MT-CO1/TPM4/MYL4/ATP1B3/MT-CO2/ATP2A2	4.063911898971
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	15/279	205/9376	2.45895620246525	COL1A1/COL3A1/GAPDH/NDUFA4/CYBA/SLC2A1/MT-CO3/UQCRH/COL1A2/MT-CO1/NDUFV3/MT-CO2/REN/ATP2A2/INSR	3.69870318223687
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/279	275/9376	2.19964809384164	TUBA1B/HSPA5/TUBB/TUBA1C/TUBB4B/NDUFA4/CAV1/CYBA/MT-CO3/TUBB6/PSMA7/UQCRH/MT-CO1/HSPA8/NDUFV3/MT-CO2/PSMB2/PSMB1	3.53601664343412
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/279	93/9376	3.25216788067985	ACTB/ACTN4/IQGAP1/ACTN1/ACTG1/CTNNB1/HEG1/VCL/INSR	3.82240501337252
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/279	44/9376	4.58260019550342	MAN1A2/B4GALT1/OSTC/STT3B/ALG9/DAD1	4.17134356257518
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/279	194/9376	2.425156117208	TUBA1B/TUBB/TUBA1C/TUBB4B/ACTB/TUBB6/DYNLL1/ACTG1/TPM2/TPM4/MYL4/MYO10/MYO1B/CENPE	3.51263726605877
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/279	238/9376	2.25920905996807	RPS4X/RPL29/C1R/RPL7A/CFD/RPL22L1/RPS3A/RPSA/RPL36/RPS18/C1S/RPL5/RPS15/RPL19/RPL14/RPS5	3.44587392612872
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/279	31/9376	5.42027980113308	HSPA5/SPCS3/SEC11C/SEC11A/SEC61A1	4.31697563342347
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/279	116/9376	2.89704610060561	ENO1/GAPDH/TPI1/PKM/GPT2/ACAT2/PGK1/ADH5/PHGDH/PRPS2	3.60031109374471
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/279	138/9376	2.67871798867591	CCNB1/PTTG1/CALM1/SMC1A/CALM3/CCNE1/CDC20/IGF1/AURKA/CCNB2/SMC3	3.4791003130483
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	14/279	204/9376	2.30627591538408	COL1A1/ACTB/CAV1/LUM/DCN/EZR/IQGAP1/COL1A2/ACTG1/CTNNB1/GRB2/IGF1/WNT2/DDX5	3.30336545424741
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/279	70/9376	3.36057347670251	HLA-G/HLA-C/ACTB/CAV1/ACTG1/EIF4G1/SGCB	3.47155189289421
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/279	108/9376	2.80047789725209	RAN/KPNA2/PNN/RBM8A/IPO9/KPNB1/XPO1/NUP37/DDX39B	3.29568201493539
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/279	89/9376	3.02074020377754	COL1A1/COL6A2/COL6A3/LAMA4/COL1A2/COL6A1/HMMR/LAMB1	3.35433477877912
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/279	110/9376	2.74956011730205	LDHA/ENO1/GAPDH/LDHB/SLC2A1/PGK1/TIMP1/IGF1/INSR	3.23234499066658
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/279	56/9376	3.60061443932412	MAN1A2/B4GALT1/OSTC/STT3B/ALG9/DAD1	3.41822518244733
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/279	75/9376	3.13653524492234	CCNB1/RRM2/CCNE1/PERP/SIVA1/IGF1/CCNB2	3.25322808919845
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/279	224/9376	2.10035842293907	CALR/HLA-G/HLA-C/RAN/PTTG1/SLC2A1/CCNE1/RANBP1/CDC20/BUB3/TLN1/CCNB2/XPO1/CCNA2	2.91903174555437
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/279	248/9376	2.0326049254249	TUBA1B/TUBB/TUBA1C/GAPDH/HSP90B1/TUBB4B/ACTB/HSP90AB1/HSP90AA1/TUBB6/DYNLL1/ACTG1/CTNNB1/CASP4/AHNAK	2.88609657513018
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/279	76/9376	3.09526504433126	CALM1/ACTB/EZR/CALM3/ACTG1/GAST/ATP1B3	3.21175886842861
NA	NA	hsa04517	IgSF CAM signaling	17/279	299/9376	1.91069394996464	TUBA1B/TUBB/TUBA1C/TUBB4B/ACTB/SPTBN1/JAM3/EZR/ACTN4/IQGAP1/TUBB6/ACTN1/DYNLL1/ACTG1/CTNNB1/GRB2/VCL	2.80269294524758
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/279	103/9376	2.61015415666214	COL1A1/COL3A1/ACTN4/ACTN1/LAMA4/COL1A2/VCL/LAMB1	2.87749503174742
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/279	47/9376	3.5750781667048	LDHA/LDHB/PKM/ACAT2/ADH5	3.09927734391766
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/279	86/9376	2.73535050429274	DSP/ACTB/DSC2/ACTG1/CTNNB1/SGCB/ATP2A2	2.83117827728656
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/279	50/9376	3.36057347670251	HBA2/HBA1/GYPC/GYPA/GYPB	2.93084912433045
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	23/279	480/9376	1.61027479091995	TUBA1B/HSPA5/TUBB/TUBA1C/TUBB4B/CALM1/NDUFA4/CALM3/MT-CO3/TUBB6/PSMA7/UQCRH/SNCA/MT-CO1/CTNNB1/FUS/DKK1/NDUFV3/MT-CO2/PSMB2/WNT2/ATP2A2/PSMB1	2.40373897131455
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/279	51/9376	3.29467987912011	ACTB/ACTG1/PDIA4/SEC61A1/KDELR2	2.87754032117194
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/279	71/9376	2.83992124791761	LDHA/SLC16A3/LDHB/PKM/SLC2A1/SLC7A5	2.72526577933933
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/279	99/9376	2.37616306433511	ACTB/ACTG1/TPM2/TPM4/IGF1/SGCB/ATP2A2	2.41058449515471
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/279	122/9376	2.20365473882132	ACTB/SLC2A1/DIO2/ACTG1/CTNNB1/ATP1B3/BMP4/ATP2A2	2.34345026128186
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	10/279	170/9376	1.97680792747206	TUBA1B/TUBA1C/ACTB/JAM3/EZR/ACTN4/ACTN1/CLDN10/ACTG1/CLDN4	2.25079941415639
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/279	105/9376	2.24038231780167	ACTB/ACTG1/TPM2/TPM4/IGF1/SGCB/ATP2A2	2.2383374860964
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/279	106/9376	2.21924663555826	HSP90B1/HSP90AB1/HSP90AA1/CCNE1/CTNNB1/GRB2/IGF1	2.21076853034108
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/279	107/9376	2.19850601279603	LDHA/LDHB/PYGL/CALM1/PKM/SLC2A1/CALM3	2.18350558667261
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	16/279	333/9376	1.61468995877598	HLA-G/COL1A1/HLA-C/COL6A2/COL6A3/PKM/CCNE1/LAMA4/COL1A2/CTNNB1/GRB2/HEY1/COL6A1/CCNA2/WNT2/LAMB1	2.0001410011991
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/279	205/9376	1.80323454847452	HLA-G/HLA-C/PKM/CCNE1/ACTN4/RANBP1/ACTN1/CDC20/SKP2/GRB2/CCNA2	2.0363367834519
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/279	110/9376	2.1385467579016	CCNB1/HSP90AB1/HSP90AA1/IGF1/AURKA/CCNB2/CCNA2	2.1034863981799
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/279	89/9376	2.26555515283315	TUBA1B/TUBB/TUBA1C/TUBB4B/TUBB6/GRB2	2.10076270847468
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/279	137/9376	1.96237867252701	TUBA1B/TUBA1C/ACTB/LMNB2/ACTG1/LMNB1/BIRC5/CTSV	1.9871581509178
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/279	14/9376	4.80081925243215	ST3GAL1/B4GALT1	2.49227269357672
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/279	144/9376	1.86698526483473	LIFR/ID1/CTNNB1/GRB2/IGF1/BMP4/ID3/WNT2	1.8360466307908
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/279	75/9376	2.24038231780167	CGA/HSPA5/HSP90B1/PDIA4/ATP1B3	1.88868711958185
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	16/279	362/9376	1.48533634329393	COL1A1/COL6A2/HSP90B1/PGF/COL6A3/HSP90AB1/HSP90AA1/CCNE1/LAMA4/COL1A2/GRB2/IGF1/COL6A1/LAMB1/GNG11/INSR	1.64921381670085
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/279	308/9376	1.52753339850114	TUBA1B/TUBB/TUBA1C/TUBB4B/NDUFA4/MT-CO3/TUBB6/PSMA7/UQCRH/MT-CO1/NDUFV3/MT-CO2/PSMB2/PSMB1	1.6485730855931
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/279	54/9376	2.4893136864463	LDHA/LDHB/CBS/PHGDH	1.92206094260034
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/279	78/9376	2.15421376711699	ENO1/HSPD1/BTG1/LSM4/EXOSC5	1.79257536225272
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/279	78/9376	2.15421376711699	ACTB/CAV1/ACTG1/CTNNB1/VCL	1.79257536225272
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/279	56/9376	2.40040962621608	HSPD1/BNIP3/HSPA8/SAR1A	1.84068633077249
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/279	154/9376	1.74575245542987	CALM1/CALM3/TPM2/TPM4/MYL4/ATP1B3/ATP2A2/ATP2B1	1.63410942901054
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/279	36/9376	2.80047789725209	ST3GAL1/GALNT1/GALNT2	1.89541471995841
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/279	157/9376	1.71239412825606	HLA-G/CCNB1/HLA-C/CALM1/CALM3/CCNE1/CCNB2/CCNA2	1.57640169235076
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/279	157/9376	1.71239412825606	LEP/NDUFA4/MT-CO3/UQCRH/MT-CO1/NDUFV3/MT-CO2/INSR	1.57640169235076
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/279	37/9376	2.72478930543447	HBA2/HBA1/LAMA4	1.84087952555433
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/279	59/9376	2.27835489945933	MGST1/RRM2/ODC1/MGST3	1.72495607632329
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/279	212/9376	1.5851761682559	CALM1/ACTB/PGF/CALM3/ACTG1/ID1/CTNNB1/IGF1/TLN1/INSR	1.50921343811774
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/279	133/9376	1.768722882475	CCNB1/BNIP3/SKP2/GRB2/IGF1/CCNB2/INSR	1.56360768143519
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/279	38/9376	2.65308432371251	ATP1B3/IGF1/INSR	1.78812762812103
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	10/279	214/9376	1.57036143771145	CALR/HLA-G/CCNB1/HLA-C/CALM1/CALM3/PDIA3/CCNB2/WEE1/GNG11	1.47808884867628
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/279	61/9376	2.20365473882132	ATP1B3/MT1E/SLC6A19/ATP2B1	1.65163493492062
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/279	216/9376	1.55582105402894	HSPA5/HSPA2/HSP90B1/CALM1/CYBA/HSP90AB1/HSP90AA1/HSPD1/CALM3/HSPA8	1.44728071334934
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/279	20/9376	3.36057347670251	SQLE/EBP	1.85065752241279
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/279	139/9376	1.69237513215234	HSP90B1/CALM1/HSP90AB1/HSP90AA1/CALM3/HSPA8/GRB2	1.4401974308218
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/279	88/9376	1.90941674812643	TFPI/C1R/CFD/PROCR/C1S	1.50100390896101
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/279	41/9376	2.45895620246525	ALAS2/CBS/PHGDH	1.63951601913823
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/279	142/9376	1.65662072795194	CBLB/CDC20/UBE2C/SKP2/FBXW7/HUWE1/UBE2S	1.38070999208917
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/279	143/9376	1.64503596761661	C1R/ACTN4/ACTN1/SNRPB/SSB/C1S/SNRPD1	1.36119133329927
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/279	170/9376	1.58144634197765	MGST1/ACTB/MGST3/ACTG1/CTNNB1/GRB2/SMARCA2/WNT2	1.33979163055482
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	10/279	227/9376	1.48042884436234	MGST1/NDUFA4/CYBA/MT-CO3/UQCRH/MGST3/MT-CO1/GRB2/NDUFV3/MT-CO2	1.28319846464854
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/279	44/9376	2.29130009775171	HLA-G/HLA-C/HSPD1	1.50350473292273
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/279	93/9376	1.80675993371103	CGA/CALM1/CALM3/GRB2/MMP14	1.36924216070173
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/279	46/9376	2.1916783543712	PSMA7/PSMB2/PSMB1	1.41884772230968
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/279	235/9376	1.43003126668192	ACTB/NDUFA4/MT-CO3/UQCRH/ACTG1/MT-CO1/GRB2/SMARCA2/NDUFV3/MT-CO2	1.1691648563462
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/279	180/9376	1.49358821186778	CALR/HLA-G/HLA-C/SRSF7/PDIA3/SRSF3/SRSF2/SRSF6	1.17095496617017
NA	NA	hsa03272	Virion - Hepatitis viruses	3/279	48/9376	2.10035842293907	CLDN10/CLDN4/EPCAM	1.338440793251
Organismal Systems	Immune system	hsa04611	Platelet activation	6/279	126/9376	1.60027308414405	COL1A1/COL3A1/ACTB/COL1A2/ACTG1/TLN1	1.1879602770688
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/279	49/9376	2.05749396532807	B4GALT1/GALNT1/GALNT2	1.29970141522055
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/279	75/9376	1.79230585424134	MGST1/MGST3/TOP2A/BIRC5	1.20641663477355
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/279	157/9376	1.49834486222405	ACTB/ACTG1/ID1/CTNNB1/BIRC5/BMP4/WNT2	1.1027486794528
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/279	76/9376	1.768722882475	CALM1/CALM3/GRB2/IGF1	1.17834855396116
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/279	217/9376	1.39378623457708	MGST1/HSP90B1/HSP90AB1/KPNA2/HSP90AA1/MGST3/GRB2/BIRC5/KPNB1	1.02779147356913
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/279	52/9376	1.93879239040529	CGA/IGF1/INSR	1.1887998525308
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/279	78/9376	1.72337101369359	CALM1/C1R/CALM3/C1S	1.12344618809548
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/279	29/9376	2.31763688048449	CALM1/CALM3	1.24450676653667
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/279	54/9376	1.86698526483473	CGA/HLA-G/HLA-C	1.11890364703831
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/279	30/9376	2.24038231780167	ABCG2/GGH	1.19163142608381
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/279	138/9376	1.46111890291413	NDUFA4/MT-CO3/UQCRH/MT-CO1/NDUFV3/MT-CO2	0.955657192156752
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/279	138/9376	1.46111890291413	PYGL/CALM1/CBLB/CALM3/GRB2/INSR	0.955657192156752
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/279	110/9376	1.52753339850114	DCN/ID1/LRRC32/BMP4/ID3	0.974627805693224
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/279	227/9376	1.3323859599261	CALR/HLA-G/HLA-C/CALM1/CALM3/PDIA3/CTNNB1/GRB2/GNG11	0.887784233717308
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/279	32/9376	2.10035842293907	LDHA/LDHB	1.09189628646835
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/279	10/9376	3.36057347670251	SELENBP1	1.30791369986932
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/279	238/9376	1.27080509623204	PLA2G2A/CALM1/PGF/CALM3/RALBP1/GRB2/IGF1/GNG11/INSR	0.741068540431586
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/279	148/9376	1.36239465271723	CTNNB1/GRB2/HEY1/IGF1/BRCA2/WNT2	0.77821122014392
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/279	62/9376	1.62608394033992	HSPA8/IGF1/INSR	0.866161616497221
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/279	63/9376	1.60027308414405	CTNNB1/BMP4/WNT2	0.837168706629365
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/279	36/9376	1.86698526483473	PYGL/GYG2	0.91270025333985
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/279	122/9376	1.37728421176332	LEP/SCD/IGF1/CCNA2/INSR	0.73455182463709
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/279	93/9376	1.44540794696882	CALM1/CALM3/ATP1B3/ATP2B1	0.755951447534032
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/279	93/9376	1.44540794696882	CCNE1/LAMA4/SKP2/LAMB1	0.755951447534032
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/279	39/9376	1.72337101369359	HLA-G/HLA-C	0.792735612508381
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/279	13/9376	2.58505652054039	PRKDC	1.00149217420636
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/279	157/9376	1.28429559619204	CALR/SLC2A1/ODC1/ATP11A/SLC16A1/ATP2A2	0.629095666554847
NA	NA	hsa04081	Hormone signaling	8/279	219/9376	1.22760674948037	CGA/LEP/DIO2/GAST/IGF1/RAMP1/GNG11/INSR	0.596855540020343
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/279	158/9376	1.27616714305159	SKP2/GRB2/IGF1/SLC7A5/WNT2/INSR	0.613085212642396
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/279	98/9376	1.37166264355204	CALM1/CALM3/ATP1B3/ATP2B1	0.647699270400951
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/279	69/9376	1.46111890291413	CALM1/CALM3/REN	0.673242085699807
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/279	253/9376	1.19546092056611	ACTB/ACTN4/BNIP3/ACTN1/ACTG1/U2AF1/TLN1/CASP4/VCL	0.551937631373418
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/279	160/9376	1.26021505376344	HLA-G/HLA-C/JAM3/VCAN/CLDN10/CLDN4	0.581379639399903
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/279	130/9376	1.2925282602702	COL1A1/COL3A1/COL1A2/GRB2/GNG11	0.58816774256486
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/279	41/9376	1.63930413497683	SSBP1/BRCA2	0.71842415051578
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/279	101/9376	1.33092018879307	CALM1/CALM3/CTNNB1/WNT2	0.585552222427126
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/279	102/9376	1.31787195164804	PLA2G2A/ATP1B3/ATP2A2/ATP2B1	0.565271892184271
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/279	15/9376	2.24038231780167	ST3GAL1	0.841935294725419
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/279	103/9376	1.30507707833107	PNN/RBM8A/FUS/DDX39B	0.545201075043325
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/279	43/9376	1.56305743102442	ACAT2/ADH5	0.648059575317307
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/279	43/9376	1.56305743102442	PLA2G2A/ACAT2	0.648059575317307
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/279	134/9376	1.2539453271278	PLA2G2A/CALM1/CALM3/PPP1R14A/RAMP1	0.518499432414356
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/279	73/9376	1.38105759316541	MGST1/MGST3/ADH5	0.572373056789105
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/279	73/9376	1.38105759316541	RAN/MAP1B/XPO1	0.572373056789105
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/279	166/9376	1.21466511206115	CALM1/CALM3/ATP1B3/ATP2A2/ATP2B1/INSR	0.488679745346739
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/279	16/9376	2.10035842293907	ST3GAL1	0.77142708261448
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/279	232/9376	1.15881844024224	ACTB/EZR/ACTN4/IQGAP1/ACTN1/ACTG1/DIAPH3/VCL	0.428958672598528
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/279	45/9376	1.49358821186778	HLA-G/HLA-C	0.581226736595819
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/279	46/9376	1.46111890291413	ALAS2/BLVRB	0.54902189228643
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/279	47/9376	1.43003126668192	PKM/INSR	0.517571147639757
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/279	205/9376	1.14751289448378	CALR/HLA-G/HLA-C/CCNE1/PDIA3/SKP2/CCNA2	0.373970384666936
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/279	79/9376	1.27616714305159	MGST1/MGST3/ADH5	0.431670907012479
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/279	144/9376	1.1668657905217	PSMA7/NOP56/PSMB2/ATP2A2/PSMB1	0.353377831098459
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/279	82/9376	1.22947810123263	MGST1/RRM2/MGST3	0.365498401862411
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/279	21/9376	1.60027308414405	CHSY1	0.48225336228383
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/279	53/9376	1.26814093460472	ATP1B3/ATP2B1	0.342816608376939
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/279	87/9376	1.15881844024224	CTNNB1/GRB2/BIRC5	0.260624184767068
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/279	23/9376	1.46111890291413	GPT2	0.38773947611981
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/279	23/9376	1.46111890291413	B4GALT1	0.38773947611981
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/279	23/9376	1.46111890291413	ACAT2	0.38773947611981
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/279	23/9376	1.46111890291413	SSBP1	0.38773947611981
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/279	23/9376	1.46111890291413	REN	0.38773947611981
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/279	23/9376	1.46111890291413	ATP1B3	0.38773947611981
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/279	90/9376	1.12019115890084	ABCG2/SLC2A1/ATP1B3	0.200640259228633
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/279	57/9376	1.17914858831667	SCD/ACAT2	0.237577224703141
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/279	226/9376	1.0408855901291	CGA/CALM1/CALM3/PDE4D/ATP1B3/ATP2A2/ATP2B1	0.108956359914962
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/279	59/9376	1.13917744972966	CGA/INSR	0.187799951093316
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/279	59/9376	1.13917744972966	CTNNB1/GRB2	0.187799951093316
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/279	196/9376	1.02874698266403	HLA-G/HLA-C/CALM1/CALM3/CTNNB1/GNG11	0.0712258440755521
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/279	128/9376	1.05017921146953	RRM2/PDE4D/PAICS/PRPS2	0.100102183142498
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/279	94/9376	1.07252345001144	HSP90B1/HSP90AB1/HSP90AA1	0.123754284323999
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/279	26/9376	1.2925282602702	PLA2G2A	0.261569642824765
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/279	97/9376	1.03935262166057	CALM1/CALM3/GNG11	0.0682256359418729
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/279	27/9376	1.24465684322315	ACAT2	0.22294375544261
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/279	27/9376	1.24465684322315	SCD	0.22294375544261
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/279	63/9376	1.0668487227627	ACAT2/PLOD1	0.0932303317495502
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/279	63/9376	1.0668487227627	PTGDS/PLA2G2A	0.0932303317495502
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/279	99/9376	1.01835559900076	CALM1/CALM3/IGF1	0.0321529646429571
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/279	99/9376	1.01835559900076	C1R/CFD/C1S	0.0321529646429571
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/279	28/9376	1.20020481310804	B4GALT1	0.185794485795768
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/279	28/9376	1.20020481310804	GGH	0.185794485795768
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/279	101/9376	0.998190141594805	COL1A1/COL3A1/COL1A2	-0.00320248400469517
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/279	173/9376	0.971264010607662	ACTB/KPNA2/ACTG1/DNAJC3/XPO1	-0.066807179627871
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/279	30/9376	1.12019115890084	PLA2G2A	0.11546727168564
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/279	67/9376	1.00315626170224	CALM1/CALM3	0.00454043574822032
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/279	140/9376	0.960163850486431	CALM1/CALM3/MYL4/GNG11	-0.0831645136137242
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/279	68/9376	0.988403963736032	GRB2/CCNA2	-0.0168063915108662
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/279	31/9376	1.08405596022662	PRPS2	0.0820915300541148
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/279	31/9376	1.08405596022662	ACAT2	0.0820915300541148
NA	NA	hsa04981	Folate transport and metabolism	1/279	31/9376	1.08405596022662	ABCG2	0.0820915300541148
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/279	105/9376	0.960163850486431	BNIP3/TOMM20/HUWE1	-0.0718865026357294
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/279	105/9376	0.960163850486431	CALM1/CBLB/CALM3	-0.0718865026357294
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/279	69/9376	0.974079268609423	CALM1/CALM3	-0.03784474493232
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/279	178/9376	0.94398131368048	CTNNB1/DKK1/LGR4/WNT2/CACYBP	-0.132140169967219
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/279	32/9376	1.05017921146953	B4GALT1	0.0497933159952995
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/279	32/9376	1.05017921146953	BIRC5	0.0497933159952995
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/279	70/9376	0.960163850486431	LEP/SLC2A1	-0.0585846031120492
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/279	70/9376	0.960163850486431	MGST1/MGST3	-0.0585846031120492
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/279	70/9376	0.960163850486431	SLC2A1/GRB2	-0.0585846031120492
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/279	144/9376	0.933492632417364	SCD/ADH5/CTNNB1/TRA2A	-0.140845102132321
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/279	71/9376	0.946640415972538	CGA/GRB2	-0.0790354742163051
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/279	33/9376	1.01835559900076	GPT2	0.0184978391835454
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/279	109/9376	0.924928479826379	PYGL/SLC2A1/INSR	-0.138056710197279
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/279	112/9376	0.900153609831029	LAMA4/HSPA8/LAMB1	-0.186157590329892
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/279	35/9376	0.960163850486431	TPI1	-0.0413478881046405
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/279	150/9376	0.896152927120669	CCNE1/CTNNB1/GRB2/WNT2	-0.224528671402662
NA	NA	hsa04519	Cadherin signaling	11/279	404/9376	0.915007629795238	DSP/ACTB/DSC2/ACTN4/ACTN1/ACTG1/CTNNB1/MYO1B/LIMA1/WNT2/VCL	-0.305819119289824
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/279	36/9376	0.933492632417364	SSBP1	-0.0700142132787115
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/279	115/9376	0.876671341748481	GCM1/PDE4D/MMP14	-0.233035790764018
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/279	77/9376	0.872876227714937	RALBP1/BRCA2	-0.19615196037839
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/279	37/9376	0.908263101811489	GPT2	-0.0979114243583232
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/279	37/9376	0.908263101811489	ADH5	-0.0979114243583232
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/279	37/9376	0.908263101811489	GNPNAT1	-0.0979114243583232
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/279	37/9376	0.908263101811489	CTNNB1	-0.0979114243583232
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/279	154/9376	0.872876227714937	CALM1/ACTB/CALM3/ACTG1	-0.278556447826465
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/279	117/9376	0.861685506846797	ACTB/ACTG1/SMARCA2	-0.263643592547469
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/279	38/9376	0.884361441237502	GNPNAT1	-0.12508527171496
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/279	156/9376	0.861685506846797	CLDN10/CTNNB1/CLDN4/GRB2	-0.305072577093173
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/279	39/9376	0.861685506846797	CBS	-0.151577575508209
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/279	80/9376	0.840143369175627	GRB2/IGF1	-0.251458449812169
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/279	195/9376	0.861685506846797	HMGB1/ACTB/CYBA/ACTG1/CASP4	-0.341805183149731
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/279	120/9376	0.840143369175627	CALM1/CALM3/GRB2	-0.308637184105743
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/279	201/9376	0.835963551418535	FUS/IGF1/CCNA2/MYCN/DDX5	-0.411693483577558
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/279	42/9376	0.800136542072026	ACAT2	-0.227333158779018
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/279	163/9376	0.824680607779757	CCNE1/GRB2/BIRC5/CCNA2	-0.395422944299441
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/279	86/9376	0.781528715512211	CBLB/GRB2	-0.356430100618093
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/279	86/9376	0.781528715512211	SLC2A1/ATP1B3	-0.356430100618093
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/279	44/9376	0.76376669925057	HMGB1	-0.275054486845566
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/279	44/9376	0.76376669925057	DYNLL1	-0.275054486845566
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/279	168/9376	0.800136542072026	HMGB1/PYGL/HSP90AB1/HSP90AA1	-0.457766518847731
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/279	45/9376	0.746794105933891	ABCG2	-0.298163594584171
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/279	89/9376	0.755185050944384	SLC38A2/GNG11	-0.40638143213421
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/279	90/9376	0.746794105933891	IGF1/INSR	-0.422687464604257
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/279	91/9376	0.738587577297255	PDE4D/GNG11	-0.438828279014202
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/279	250/9376	0.806537634408602	HLA-G/HLA-C/CAV1/CBLB/HSPA8/EEA1	-0.542956339754352
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/279	133/9376	0.758024092489288	HLA-G/HLA-C/GRB2	-0.492186971835462
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/279	133/9376	0.758024092489288	CALM1/CALM3/GNG11	-0.492186971835462
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/279	48/9376	0.700119474313023	ACAT2	-0.364765080462541
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/279	48/9376	0.700119474313023	ATP1B3	-0.364765080462541
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/279	136/9376	0.741302972802024	CBLB/CCNE1/HSPA8	-0.532186126919479
NA	NA	hsa04382	Cornified envelope formation	5/279	217/9376	0.774325685876154	DSP/PADI1/CLDN10/CLDN4/PLEC	-0.589015347652154
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/279	50/9376	0.672114695340502	ODC1	-0.407096990424764
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/279	51/9376	0.658935975824021	PLA2G2A	-0.42769603315817
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/279	181/9376	0.742668171646963	CALM1/HSPD1/CALM3/EEA1	-0.6122031626284
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/279	98/9376	0.685831321776022	CALM1/CALM3	-0.547504106745146
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/279	99/9376	0.678903732667174	GRB2/IGF1	-0.562454917984981
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/279	183/9376	0.734551579607106	RAN/NOP56/NOP58/XPO1	-0.635061379748869
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/279	142/9376	0.709980311979403	CYBA/GRB2/ATP2A2	-0.60983923307083
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/279	100/9376	0.672114695340502	CXCL14/CCR7	-0.577271643993922
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/279	54/9376	0.622328421611576	BRCA2	-0.487410944085745
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/279	187/9376	0.718839246353478	CYBA/HSP90AB1/HSP90AA1/CASP4	-0.680111343964129
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/279	191/9376	0.703785021298955	CALM1/CALM3/GRB2/GNG11	-0.724307131871441
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/279	149/9376	0.676625532221982	NDUFA4/NDUFV3/GNG11	-0.696798558136721
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/279	193/9376	0.69649191226995	CXCL14/GRB2/CCR7/GNG11	-0.746096964823709
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/279	59/9376	0.569588724864832	RRM2	-0.58077811152167
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/279	60/9376	0.560095579450418	IGF1	-0.598629140497971
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/279	109/9376	0.616618986550919	HSP90AB1/HSP90AA1	-0.705038626452068
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/279	155/9376	0.650433576135969	CCNE1/CTNNB1/WNT2	-0.768502336413077
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/279	62/9376	0.542027980113308	HEY1	-0.63358562565937
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/279	65/9376	0.517011304108078	CGA	-0.684280436753238
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/279	116/9376	0.579409220121122	SLC38A2/GNG11	-0.798218688645075
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/279	68/9376	0.494201981868016	ADH5	-0.733064240628511
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/279	69/9376	0.487039634304711	GRB2	-0.748931575564447
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/279	168/9376	0.600102406554019	LEP/LIFR/GRB2	-0.9159239570113
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/279	122/9376	0.550913684705329	CBLB/GRB2	-0.874346612007675
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/279	122/9376	0.550913684705329	GRB2/IGF1	-0.874346612007675
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/279	71/9376	0.473320207986269	JAM3	-0.780110787605213
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/279	300/9376	0.672114695340502	PGF/HSPA8/GRB2/IGF1/STMN1/INSR	-1.01082035528952
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/279	73/9376	0.460352531055138	IGF1	-0.810585268286182
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/279	73/9376	0.460352531055138	GRB2	-0.810585268286182
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/279	76/9376	0.442180720618751	SCD	-0.855061760506293
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/279	77/9376	0.436438113857469	GRB2	-0.869575900513059
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/279	78/9376	0.430842753423399	TPI1	-0.883941334376231
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/279	78/9376	0.430842753423399	CYBA	-0.883941334376231
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/279	83/9376	0.404888370687049	AURKB	-0.953670079269667
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/279	138/9376	0.487039634304711	ACTB/ACTG1	-1.06309730455649
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/279	85/9376	0.395361585494413	RRM2	-0.980646789966563
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/279	91/9376	0.369293788648627	GRB2	-1.0587550447272
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/279	149/9376	0.451083688147988	GRB2/INSR	-1.18279002440838
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	5/279	298/9376	0.563854610184985	LEP/CXCL14/LIFR/BMP4/CCR7	-1.3399326557842
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/279	154/9376	0.436438113857469	ALAS2/GGH	-1.23488938624497
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/279	254/9376	0.52922416955945	CALM1/CALM3/ATP2A2/ATP2B1	-1.33206256956987
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/279	98/9376	0.342915660888011	MYO10	-1.14510579531819
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/279	99/9376	0.339451866333587	GRB2	-1.15706280061292
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/279	100/9376	0.336057347670251	GYPA	-1.16893090657449
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/279	103/9376	0.326269269582768	CALR	-1.20401939248475
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/279	104/9376	0.323132065067549	PLA2G2A	-1.21554919915011
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/279	169/9376	0.39770100316006	HMGB1/BNIP3	-1.3836780866006
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/279	323/9376	0.520212612492648	EZR/CCNE1/IGF2BP1/GRB2/STMN1	-1.53671195758884
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/279	115/9376	0.292223780582827	GNG11	-1.33737927027043
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/279	115/9376	0.292223780582827	GNG11	-1.33737927027043
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/279	119/9376	0.282401132496009	MMP14	-1.37961763133179
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/279	250/9376	0.268845878136201	LAPTM4B/CTSV	-2.05199995663202
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/279	370/9376	0.363305240724596	CGA/LEP/GZMA/TMEM97	-2.18828966044363
NA	NA	hsa04082	Neuroactive ligand signaling	1/279	199/9376	0.168873039030277	GNG11	-2.07530620926546
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/279	449/9376	0.149691468895435	CALM1/CALM3	-3.2335946821713