category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	116/911	222/9376	5.37779491895848	RPS4X/RPL6/RPLP0/RPL29/RPS2/RPS3A/RPL11/RPL37/RPS15/RPS18/RPS7/RPS6/RPL5/RPL37A/RPL7A/RPS3/RPSA/RPL14/RPL8/RPL18A/RPL36/RPL23A/RPL13/RPL24/RPL18/RPS24/RPS27A/RPL21/RPLP2/RPL35/RPL19/RPS13/RPS14/RPL35A/RPS23/RPS8/RPL32/RPS5/RPL3/RPL15/RPL22/RPS19/RPL38/RPL7/RPS16/RPS26/RPL12/RPL4/RPL13A/RPL39/RPL27/RPL34/RPL31/RPL28/RPLP1/RPL10A/MRPL51/RPL23/RPL26/RPS27/RPL27A/RPS29/RPL9/RPS11/RPS25/RPS9/RPL30/RPS12/RPS15A/MRPS15/RPS20/RPL41/UBA52/MRPL17/MRPL11/RPS21/MRPL20/RPS28/MRPL14/MRPL23/RPL22L1/MRPL13/MRPL27/RPS10/RPL10/RPL36A/MRPS26/MRPL37/MRPS34/MRPS35/MRPS16/MRPL52/MRPS33/MRPS6/MRPS7/MRPL9/MRPS31/MRPS5/MRPL22/MRPL3/MRPL42/MRPL39/RPL26L1/MRPL12/RPL36AL/MRPL15/RPL17/MRPL55/MRPL32/MRPL40/DAP3/MRPL35/MRPL21/MRPS12/MRPS21/MRPL41	21.6549802265374
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	70/911	158/9376	4.55974099959705	CCNB1/CDC20/CDK1/CDC6/CCNE1/CCNA2/CCNB2/MCM7/MAD2L1/PCNA/FBXO5/AURKB/NDC80/PTTG1/CDC45/ORC6/PKMYT1/CDT1/CHEK1/MCM4/WEE1/SKP2/TTK/MCM6/RAD21/YWHAE/SMC1A/CDCA5/CDK7/SMC3/PRKDC/SFN/CCNE2/PLK1/MCM5/CDC25A/TRIP13/BUB3/YWHAQ/ANAPC11/ESCO2/MCM2/CDKN1C/BUB1/MCM3/ORC1/DBF4/CDC25C/CDK2/BUB1B/TFDP1/E2F1/E2F2/TFDP2/TICRR/CDC7/ESPL1/CCND3/TGFB1/CUL1/DDX11/YWHAB/YWHAZ/CDK4/RBL1/E2F4/CDKN2C/RBX1/HDAC1/PPP2R1B	14.8033476229707
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	81/911	238/9376	3.50273501277569	RPS4X/RPL6/RPLP0/RPL29/RPS2/RPS3A/RPL11/RPL37/RPS15/RPS18/RPS7/RPS6/RPL5/RPL37A/RPL7A/RPS3/RPSA/RPL14/RPL8/RPL18A/RPL36/RPL23A/RPL13/RPL24/RPL18/RPS24/RPS27A/RPL21/RPLP2/RPL35/RPL19/RPS13/RPS14/RPL35A/RPS23/RPS8/RPL32/RPS5/RPL3/RPL15/RPL22/RPS19/RPL38/RPL7/RPS16/RPS26/RPL12/RPL4/RPL13A/RPL39/RPL27/RPL34/RPL31/RPL28/RPLP1/RPL10A/RPL23/RPL26/RPS27/RPL27A/RPS29/RPL9/RPS11/RPS25/RPS9/RPL30/RPS12/RPS15A/RPS20/RPL41/UBA52/RPS21/RPS28/RPL22L1/RPS10/RPL10/RPL36A/RPL26L1/RPL36AL/RPL17/MAPK12	12.8294818440883
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	27/911	36/9376	7.71899012074643	FEN1/MCM7/PCNA/MCM4/RPA3/RNASEH2A/MCM6/POLD3/RFC4/PRIM1/RFC3/SSBP1/RFC2/MCM5/RFC5/MCM2/MCM3/DNA2/LIG1/POLD2/POLA2/POLE2/RFC1/RNASEH2C/POLE/POLA1/RPA2	13.2499170756798
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	25/911	46/9376	5.59347110199017	PSMA7/PSMB2/PSMB1/PSMC3/PSMB5/PSMA4/PSMD12/PSMD4/PSMB6/PSMD11/PSMB3/PSMD2/POMP/PSMA1/PSMD14/PSMD7/PSMD1/PSMA3/ADRM1/PSMB4/PSMC5/PSMD3/PSMB7/PSMD13/PSMC1	10.2449637946709
Genetic Information Processing	Transcription	hsa03040	Spliceosome	63/911	243/9376	2.66829288124568	SNRPB/HNRNPA1/SNRPD1/SNRPD2/HNRNPA3/SNRPG/U2AF1/SNRPF/HNRNPC/RBM8A/SRSF7/ALYREF/HNRNPM/HNRNPU/SRSF2/SRSF3/SNRPA1/LSM3/LSM4/SNRPE/LSM2/SRSF9/SNRPD3/DDX46/LSM5/LSM7/THOC7/SNRPA/RBM17/HNRNPK/MAGOH/RBM25/FUS/RBMX/SNRNP70/SF3B2/MAGOHB/U2SURP/TRA2B/SNRNP40/SRSF4/THOC3/PPIH/SRSF10/SRSF1/SNW1/TXNL4A/LSM6/PRPF40A/SNRPC/SF3A3/WBP11/CWC15/PRPF4/EIF4A3/PRPF19/SF3B4/PRPF31/ACIN1/TCERG1/THOC6/PPIL1/PUF60	8.64370726072676
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	65/911	268/9376	2.49619083506725	TUBA1B/TUBB/RPS27A/HSPA5/CALM1/TUBA1C/TUBB4B/TUBB6/PSMA7/NDUFA6/PSMB2/SLC39A10/PSMB1/UBA52/PSMC3/COX5B/NDUFV2/CALM3/VDAC1/PSMB5/PSMA4/PARK7/UBE2L3/UQCRH/PSMD12/TXN2/PSMD4/COX5A/VDAC2/PSMB6/COX6C/GNAI1/NDUFC1/NDUFB11/NDUFC2/PSMD11/PSMB3/NDUFA4/PSMD2/NDUFS5/GNAS/NDUFB4/SLC25A4/NDUFB10/PSMA1/PSMD14/PSMD7/NDUFA11/COX8C/MT-CO3/PSMD1/PSMA3/NDUFA12/ADRM1/PSMB4/NDUFV3/PSMC5/EIF2S1/PSMD3/GNAI3/PSMB7/PSMD13/PSMC1/SLC39A1/MT-ND6	8.15218865962482
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	15/911	23/9376	6.7121653223882	PCNA/EXO1/RPA3/POLD3/RFC4/RFC3/SSBP1/RFC2/MSH2/RFC5/LIG1/POLD2/MSH6/RFC1/RPA2	8.99747326086879
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	74/911	368/9376	2.06958430773636	TUBA1B/TUBB/HNRNPA1/HSPA5/TUBA1C/PFN1/HNRNPA3/TUBB4B/HNRNPA2B1/SRSF7/TUBB6/PSMA7/ALYREF/SRSF3/NDUFA6/PSMB2/PSMB1/PSMC3/NUP37/COX5B/ACTG1/NDUFV2/VDAC1/PSMB5/PSMA4/UQCRH/PSMD12/PSMD4/COX5A/FUS/PSMB6/COX6C/VCP/GPX8/TOMM40/NDUFC1/NDUFB11/NDUFC2/PSMD11/TPR/NUP54/NUP155/ACTB/PSMB3/NDUFA4/PSMD2/NDUFS5/NDUFB4/NDUFB10/SIGMAR1/PSMA1/MATR3/PSMD14/PSMD7/NDUFA11/COX8C/MT-CO3/PSMD1/PSMA3/NDUFA12/ADRM1/PSMB4/NDUFV3/PSMC5/MAPK12/EIF2S1/PSMD3/VAPB/PSMB7/NUP107/PSMD13/PSMC1/TARDBP/MT-ND6	6.86682672421096
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	18/911	44/9376	4.21035824767987	HMGB1/FEN1/PCNA/POLD3/RFC4/RFC3/RFC2/UNG/RFC5/LIG1/NEIL3/POLD2/POLE2/APEX1/RFC1/PARP1/PARP2/POLE	7.00202758215736
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	56/911	275/9376	2.09582277217843	TUBA1B/TUBB/HSPA5/TUBA1C/TUBB4B/CAV1/TUBB6/PSMA7/NDUFA6/PSMB2/PSMB1/PSMC3/COX5B/NDUFV2/VDAC1/PSMB5/PSMA4/UQCRH/PSMD12/PSMD4/COX5A/VDAC2/PSMB6/COX6C/NDUFC1/NDUFB11/NDUFC2/PSMD11/PSMB3/NDUFA4/PSMD2/NDUFS5/NDUFB4/SLC25A4/NDUFB10/PSMA1/PSMD14/PSMD7/NDUFA11/COX8C/MT-CO3/PSMD1/STIP1/PSMA3/NDUFA12/ADRM1/PSMB4/NDUFV3/PSMC5/MAPK12/EIF2S1/PSMD3/PSMB7/PSMD13/PSMC1/MT-ND6	6.050530526591
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	17/911	41/9376	4.26740917244518	RAD51/RPA3/POLD3/BLM/SSBP1/BRCA1/XRCC2/POLD2/BRCA2/BARD1/RAD54L/BRIP1/EME1/TOPBP1/RAD54B/BRCC3/RPA2	6.87811822687107
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	58/911	308/9376	1.93810141559867	TUBA1B/TUBB/TUBA1C/TUBB4B/TUBB6/PSMA7/NDUFA6/PSMB2/PSMB1/PSMC3/COX5B/POLR2H/NDUFV2/VDAC1/PSMB5/PSMA4/UQCRH/PSMD12/PSMD4/TFAM/POLR2F/COX5A/VDAC2/PSMB6/COX6C/GPX8/NDUFC1/NDUFB11/NDUFC2/PSMD11/PSMB3/NDUFA4/PSMD2/NDUFS5/POLR2I/NDUFB4/SLC25A4/PPARG/NDUFB10/PSMA1/PSMD14/PSMD7/NDUFA11/COX8C/MT-CO3/PSMD1/PSMA3/NDUFA12/ADRM1/PSMB4/NDUFV3/PSMC5/PSMD3/PSMB7/PSMD13/PSMC1/MT-ND6/HDAC1	5.49162330394078
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	28/911	108/9376	2.66829288124568	RAN/KPNA2/RBM8A/ALYREF/PNN/NUP37/SRRM1/THOC7/MAGOH/MAGOHB/CSE1L/RNPS1/TPR/SUMO2/NUP54/NUP155/THOC3/KPNB1/SAP18/RANGAP1/XPO1/IPO5/RANBP17/NUP107/EIF4A3/ACIN1/THOC6/UBE2I	5.72034875307957
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/911	63/9376	3.26729740560696	PCNA/RPA3/POLD3/RFC4/CDK7/RFC3/RFC2/POLR2H/RFC5/LIG1/POLR2F/POLD2/POLE2/RFC1/POLR2I/MNAT1/POLE/RAD23A/RBX1/RPA2	5.92332155886315
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	18/911	54/9376	3.4306622758873	UBE2T/RAD51/RPA3/USP1/FANCI/BLM/FANCB/BRCA1/BRCA2/BRIP1/EME1/FANCG/FANCD2/RMI2/RMI1/FANCA/FANCE/RPA2	5.87622338042703
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	67/911	388/9376	1.77722452951894	TUBA1B/GAPDH/TUBB/CALM1/TUBA1C/TUBB4B/TUBB6/PSMA7/NDUFA6/PSMB2/SLC39A10/PSMB1/PSMC3/COX5B/HSD17B10/NDUFV2/CALM3/VDAC1/PSMB5/PSMA4/UQCRH/PSMD12/WNT10B/NAE1/PSMD4/APP/COX5A/VDAC2/PSMB6/COX6C/NDUFC1/NDUFB11/NDUFC2/PSMD11/PSMB3/NDUFA4/AXIN2/PSMD2/NDUFS5/HRAS/NDUFB4/SLC25A4/NDUFB10/PSMA1/PSMD14/PSMD7/NDUFA11/WNT3A/COX8C/MT-CO3/PSMD1/PSMA3/CSNK1E/NDUFA12/ADRM1/PSMB4/AKT1/NDUFV3/PSMC5/EIF2S1/PSMD3/PSMB7/PSMD13/PSMC1/SLC39A1/MT-ND6/WNT7A	5.12934812186066
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	37/911	174/9376	2.18852593461776	PDIA6/CALR/HSPA5/LMAN1/HSP90B1/PDIA3/TUSC3/SSR2/MAN1A2/OSTC/HSP90AB1/PDIA4/LMAN2/ERP29/TMEM258/VCP/SSR3/P4HB/STT3B/DNAJC3/PRKCSH/CUL1/SEC61G/KRTCAP2/UBXN4/SAR1A/DNAJB11/DAD1/BAG2/ERLEC1/RAD23A/WFS1/STT3A/EIF2S1/RBX1/DDOST/CKAP4	5.19126881278516
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	21/911	75/9376	2.88175631174534	GAPDH/ENO1/TPI1/CBS/PKM/PGK1/PFKP/ALDOA/GPT2/PGAM1/PHGDH/TALDO1/IDH2/PKLR/PSAT1/SHMT1/RPIA/TKT/ALDOC/PFKL/PGAM4	5.36735766522205
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	27/911	116/9376	2.39554865816269	GAPDH/ENO1/TPI1/ACAT2/ADH5/PKM/PGK1/GCSH/PFKP/ALDOA/GPT2/PGAM1/PHGDH/PGP/TALDO1/IDH2/GLDC/PKLR/PSAT1/MDH2/SHMT1/RPIA/PDHA1/TKT/ALDOC/PFKL/PGAM4	4.96134959648534
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	30/911	138/9376	2.23738844079607	CCNB1/CDC20/CDK1/CCNE1/CCNB2/CALM1/MAD2L1/AURKA/FBXO5/PTTG1/PKMYT1/YWHAE/SMC1A/SMC3/CCNE2/PLK1/YWHAQ/ANAPC11/CALM3/BUB1/CDC25C/CDK2/PPP1CA/ESPL1/CUL1/YWHAB/YWHAZ/MAPK12/RBX1/PPP2R1B	4.80383369885514
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	75/911	480/9376	1.60812294182217	TUBA1B/TUBB/RPS27A/HSPA5/CALM1/TUBA1C/TUBB4B/TUBB6/PSMA7/NDUFA6/PSMB2/PSMB1/UBA52/PSMC3/COX5B/HSD17B10/NDUFV2/CALM3/VDAC1/PSMB5/PSMA4/PARK7/UBE2L3/UQCRH/PSMD12/WNT10B/PSMD4/APP/COX5A/VDAC2/FUS/PSMB6/COX6C/VCP/GPX8/TOMM40/NDUFC1/NDUFB11/NDUFC2/PSMD11/PSMB3/NDUFA4/AXIN2/PSMD2/NDUFS5/HRAS/NDUFB4/SLC25A4/NDUFB10/SIGMAR1/PSMA1/PSMD14/PSMD7/NDUFA11/WNT3A/COX8C/MT-CO3/PSMD1/PSMA3/CSNK1E/NDUFA12/ADRM1/PSMB4/NDUFV3/PSMC5/MAPK12/EIF2S1/PSMD3/VAPB/PSMB7/PSMD13/PSMC1/TARDBP/MT-ND6/WNT7A	4.48689560202817
Cellular Processes	Cell motility	hsa04814	Motor proteins	38/911	194/9376	2.0159561827379	TUBA1B/TUBB/TPM4/TUBA1C/CENPE/KIF2C/TUBB4B/KIFC1/KIF23/KIF20B/KIF11/TUBB6/MYO1B/TPM2/KIF4A/MYO10/ACTG1/KIF15/TPM1/KIF22/TUBG1/MYL4/KIF14/MYH10/MYL9/TPM3/KIF2A/MYL12B/ACTB/KIF20A/KIF18A/TNNI2/DYNLL2/MYL6B/KIF18B/MYO19/TNNT1/MYL12A	4.69070956828844
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/911	67/9376	2.76501138653604	LDHA/GAPDH/LDHB/ENO1/TPI1/ADH5/PKM/PGK1/PFKP/ALDOA/ALDH7A1/PGAM1/PKLR/PGM1/PDHA1/ALDOC/PFKL/PGAM4	4.75625075593323
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/911	144/9376	2.07269179168191	PSMA7/NOP56/PSMB2/PSMB1/PSMC3/VDAC1/PSMB5/PSMA4/PSMD12/PSMD4/VDAC2/PSMB6/PSMD11/PSMB3/PSMD2/SLC25A4/PSMA1/PSMD14/PSMD7/PSMD1/PSMA3/ADRM1/PSMB4/AKT1/PSMC5/PSMD3/PSMB7/PSMD13/PSMC1	4.25539276624202
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	19/911	78/9376	2.50702243237918	ENO1/HSPD1/LSM3/LSM4/PFKP/LSM2/EXOSC8/EXOSC5/BTG3/LSM5/LSM7/EXOSC9/EXOSC2/EXOSC3/PABPC4/DCPS/LSM6/PFKL/XRN2	4.38433361022258
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	30/911	157/9376	1.96662168681438	CCNB1/CDK1/CCNE1/CCNA2/CCNB2/CALM1/CHEK1/HLA-G/MYBL2/CCNE2/CDC25A/CALM3/VDAC1/FOXM1/CDK2/VDAC2/PPP1CA/E2F1/E2F2/HRAS/EIF4EBP1/SLC25A4/CCND3/TGFB1/LIN9/AKT1/MAPK12/CDK4/RBL1/E2F4	4.00678278139537
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	12/911	41/9376	3.01228882760836	CBS/GCSH/ALAS2/ALDH7A1/PGAM1/PHGDH/GLDC/GAMT/PSAT1/SHMT1/PGAM4/GCAT	4.23600465458212
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	19/911	85/9376	2.30056176147737	RRM2/TYMS/TK1/DUT/RRM1/DTYMK/GMPS/NME1/IMPDH2/CTPS1/HDDC2/ADK/ADA/AK5/AK2/NME2/AK4/AK1/NT5DC4	3.95130504716177
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/911	31/9376	3.31999575085868	HSPA5/SEC11A/SPCS3/SRP14/SEC11C/SPCS1/SRP72/UBL4A/SEC61G/SRP54	4.24433572412593
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	11/911	39/9376	2.90286807959695	TYMS/CBS/DHFR/GCSH/MTHFD1L/ALDH7A1/ATIC/GLDC/SHMT1/AHCY/GART	3.90632749554331
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/911	103/9376	1.9984440442062	RBM8A/ALYREF/PNN/SRRM1/PAPOLA/MAGOH/PPP1CA/FUS/MAGOHB/RNPS1/GSPT1/SAP18/PABPC4/FIP1L1/EIF4A3/CPSF6/ACIN1/TARDBP/CSTF2/PPP2R1B	3.34243952782401
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/911	44/9376	2.57299670691548	TUSC3/MAN1A2/OSTC/ALG9/TMEM258/STT3B/KRTCAP2/DAD1/STT3A/B4GALT1/DDOST	3.43082157152549
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/911	71/9376	2.17436341429477	LDHA/LDHB/SLC16A3/PKM/PFKP/SLC2A1/PGAM1/IDH2/HRAS/SLC7A5/PDHA1/AKT1/PFKL/FGFR3/PGAM4	3.2584033532563
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/911	59/9376	2.26772591117974	RRM2/GSTP1/PRDX6/RRM1/SRM/ODC1/GPX8/IDH2/GSTA4/GGCT/MGST3/TXNDC12/GSTA2	3.20438485574766
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/911	47/9376	2.40876287455917	LDHA/LDHB/ACAT2/ADH5/PKM/ALDH7A1/GLO1/PKLR/MDH2/PDHA1/ACACA	3.1761472303238
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/911	75/9376	2.05839736553238	RRM2/CCNB1/CDK1/CCNE1/PERP/CCNB2/SIVA1/GTSE1/CHEK1/SFN/CCNE2/CDK2/EI24/CCND3/CDK4	3.01888038173875
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/911	56/9376	2.2054257487847	TUSC3/MAN1A2/OSTC/ALG9/TMEM258/STT3B/SRD5A3/KRTCAP2/DAD1/STT3A/B4GALT1/DDOST	2.9679587926398
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	35/911	235/9376	1.5328491019922	RPS6/NDUFA6/COX5B/KDM1A/ACTG1/NDUFV2/UQCRH/COX5A/COX6C/SMARCC1/COX20/GRB2/NDUFC1/NDUFB11/SMARCA2/NDUFC2/ACTB/NDUFA4/ACTL6A/NDUFS5/HRAS/GNAS/NDUFB4/PPARG/NDUFB10/CPT1C/NDUFA11/COX8C/MT-CO3/NDUFA12/NDUFV3/NDUFAF2/MAPK12/COA6/MT-ND6	2.7137676453808
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/911	138/9376	1.71533113794365	NDUFA6/COX5B/PPA1/NDUFV2/UQCRH/COX5A/COX6C/NDUFC1/NDUFB11/NDUFC2/NDUFA4/NDUFS5/NDUFB4/ATP6V1B1/NDUFB10/NDUFA11/COX8C/MT-CO3/ATP6V1C2/NDUFA12/NDUFV3/PPA2/MT-ND6	2.77708414997263
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/911	116/9376	1.77448048752792	JAM3/EZR/CLDN7/CLDN6/ACTG1/CDH5/CLDN10/ACTN4/ACTN1/MMP2/GNAI1/MYL9/MYL12B/ACTB/VCL/CTNNA1/MAPK12/GNAI3/MYL12A/PXN	2.75337476182393
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/911	31/9376	2.65599660068694	PFKP/ALDOA/TALDO1/PGM1/RPIA/TKT/ALDOC/PFKL	3.02957689845995
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	31/911	205/9376	1.55634922759765	GAPDH/NDUFA6/SLC2A1/COX5B/NDUFV2/VDAC1/UQCRH/COX5A/VDAC2/PPP1CA/MMP2/COX6C/NDUFC1/NDUFB11/NDUFC2/NDUFA4/NDUFS5/NDUFB4/SLC25A4/PARP1/NDUFB10/NDUFA11/TGFB1/COX8C/MT-CO3/PDHA1/NDUFA12/AKT1/NDUFV3/MAPK12/MT-ND6	2.64208885258015
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	25/911	157/9376	1.63885140567865	LEP/NDUFA6/COX5B/NDUFV2/UQCRH/COX5A/COX6C/NDUFC1/NDUFB11/NDUFC2/NDUFA4/PKLR/NDUFS5/NDUFB4/PPARG/NDUFB10/NDUFA11/TGFB1/COX8C/MT-CO3/NDUFA12/AKT1/NDUFV3/MAPK12/EIF2S1	2.64812888750652
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/911	110/9376	1.77770681568706	CCNB1/CDK1/CCNA2/CCNB2/MAD2L1/AURKA/PKMYT1/PLK1/CDC25A/HSP90AB1/ANAPC11/BUB1/CDC25C/CDK2/KIF22/GNAI1/AKT1/MAPK12/GNAI3	2.69151897039854
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/911	20/9376	3.08759604829857	SQLE/EBP/FDFT1/LBR/DHCR7/MSMO1	3.0658274107847
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/911	59/9376	2.09328545647361	RRM2/TYMS/TK1/DUT/RRM1/DTYMK/NME1/CTPS1/HDDC2/UMPS/NME2/NT5DC4	2.76345803839651
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/911	15/9376	3.4306622758873	ACP1/AK5/AK2/AK4/AK1	3.0905834392207
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/911	128/9376	1.68852908891328	RRM2/PAICS/RRM1/PDE4D/GMPS/NME1/IMPDH2/PPAT/ATIC/HDDC2/ADK/ADA/PGM1/AK5/AK2/NME2/NUDT5/AK4/AK1/NT5DC4/GART	2.57296994227729
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/911	170/9376	1.57406857364241	TUBA1B/JAM3/TUBA1C/PCNA/ARPC1A/EZR/CLDN7/CLDN6/RDX/ACTG1/CLDN10/ACTN4/ACTN1/ARPC5L/MYH10/MYL9/MYL12B/ACTB/ARPC5/MYL6B/MPDZ/DLG3/CDK4/MYL12A/RAB8B/PPP2R1B	2.47790181459786
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/911	54/9376	2.09651583526446	LDHA/LDHB/CBS/PHGDH/SRM/ADI1/MTAP/PSAT1/MDH2/CISD1/AHCY	2.65087093838957
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/911	107/9376	1.73136227007397	LDHA/LDHB/PYGL/CALM1/PKM/PFKP/SLC2A1/CALM3/PGAM1/PRMT1/GNAS/CPT1C/PDHA1/AKT1/ACACA/PFKL/PGAM4/PPP4C	2.49596990854453
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/911	224/9376	1.47028383252313	RANBP1/CALR/CDC20/RAN/CCNE1/CCNA2/CCNB2/MAD2L1/PTTG1/CHEK1/HLA-G/FDPS/CCNE2/BUB3/SLC2A1/ANAPC11/VDAC1/CDK2/VDAC2/BUB1B/E2F1/E2F2/NFYB/HRAS/SLC25A4/ESPL1/CCND3/TGFB1/XPO1/AKT1/CDK4/CDKN2C	2.3369929253518
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/911	110/9376	1.68414329907195	LDHA/RPS6/GAPDH/LDHB/ENO1/PGK1/PFKP/ALDOA/ANGPT4/SLC2A1/EIF4EBP1/TF/PDHA1/AKT1/ALDOC/PFKL/RBX1/EIF4E2	2.36771059579366
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/911	30/9376	2.40146359312111	TYMS/ABCG2/DHFR/GGH/ATIC/SHMT1/GART	2.52209188476217
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/911	205/9376	1.45593960001071	CALR/CCNE1/CCNA2/HLA-G/PDIA3/SKP2/CCNE2/PSMC3/PSMD12/PSMD4/CDK2/E2F1/E2F2/PSMD11/PSMD2/PSMD14/PSMD7/CCND3/SNW1/PSMD1/ADRM1/AKT1/PSMC5/MAPK12/CDK4/PSMD3/PSMD13/PSMC1/HDAC1	2.16524599097552
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	32/911	233/9376	1.41349175315528	LMNB1/TPM4/ENO1/DIAPH3/DSC2/LMNB2/DSP/TPM2/SGCB/SPTBN1/ACTG1/CSRP1/DSG2/TPM1/CSRP2/MYL4/MYH10/MYL9/TPM3/ACTB/NID1/TNNI2/COL9A3/LBR/VCL/FLNC/PDLIM2/SYNE2/TNNT1/ATP1B2/DMD/PDLIM1	2.09667828999629
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/911	157/9376	1.50774329322436	BIRC5/YWHAE/YWHAQ/ACTG1/WNT10B/ID1/PPP1CA/TEAD4/BMP4/ACTB/AXIN2/CCND3/TGFB1/WNT3A/YWHAB/CTNNA1/CSNK1E/BMP7/DLG3/YWHAZ/CDH1/WNT7A/PPP2R1B	2.10466732995098
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/911	13/9376	3.16676517774213	FEN1/XRCC5/PRKDC/XRCC6	2.56452748140598
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/911	227/9376	1.40551361963665	ACP1/NDUFA6/COX5B/NDUFV2/VDAC1/UQCRH/COX5A/VDAC2/COX6C/GRB2/GSTA4/NDUFC1/NDUFB11/MGST3/NDUFC2/NDUFA4/NDUFS5/HRAS/NDUFB4/SLC25A4/NDUFB10/NDUFA11/COX8C/MT-CO3/NDUFA12/AKT1/NDUFV3/MAPK12/PRKD3/MT-ND6/GSTA2	2.02891057298199
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/911	87/9376	1.65618178835939	TPM4/TPM2/COX5B/UQCRH/TPM1/COX5A/MYL4/COX6C/TPM3/COX8C/MT-CO3/ASPH/SLC8A3/ATP1B2	2.01711501947903
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/911	82/9376	1.63165644828786	RRM2/TK1/DUT/GSTP1/RRM1/GMPS/NME1/IMPDH2/GSTA4/MGST3/UMPS/NME2/GSTA2	1.88459429281276
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/911	51/9376	1.8162329695874	KDELR1/KDELR2/ACTG1/PDIA4/ACTB/GNAS/ATP6V1B1/SEC61G/ATP6V1C2	1.9173709638629
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	20/911	142/9376	1.44957560952985	UBE2C/CDC20/RPS27A/SKP2/UBE2S/UBA52/ANAPC11/UBE2L3/BRCA1/UBE2F/UBA2/FBXW7/SAE1/UBE2N/CUL1/UBE2M/UBE2E3/PRPF19/RBX1/UBE2I	1.7708563141353
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/911	142/9376	1.44957560952985	CALM1/CAV1/HSP90B1/GSTP1/RAC3/HSP90AB1/ACTG1/CALM3/TXN2/CDH5/GPC1/MMP2/GSTA4/MGST3/BMP4/SUMO2/ACTB/AKT1/MAPK12/GSTA2	1.7708563141353
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	17/911	117/9376	1.49541688948934	ACTG1/RUVBL1/SMARCA5/ACTR6/BAZ1B/SMARCC1/INO80C/SMARCA2/ACTB/CDK2AP2/ACTL6A/RBBP7/YEATS4/CECR2/UCHL5/MORF4L1/HDAC1	1.76893975575971
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/911	205/9376	1.35552997242376	RANBP1/CDC20/CDK1/CCNE1/CCNA2/CHEK1/HLA-G/SKP2/YWHAE/PKM/CCNE2/YWHAQ/CDK2/ACTN4/HNRNPK/ACTN1/GRB2/HRAS/CCND3/YWHAB/SNW1/YWHAZ/CDK4/RBL1/PSMC1/PXN/HDAC1	1.68840312937089
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/911	93/9376	1.54933135040072	RAC3/ACP1/ACTG1/CDH5/ACTN4/ACTN1/MYL9/MYL12B/ACTB/VCL/CTNNA1/ARHGAP29/CDH1/MYL12A	1.74647763880037
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/911	31/9376	1.99199745051521	ACAT2/GCSH/PGP/GLDC/MDH2/SHMT1	1.81481807279397
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/911	32/9376	1.92974753018661	UGP2/PFKP/AKR1B1/PGM1/PFKL/B4GALT1	1.72824358333141
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/911	41/9376	1.75716848277155	MMP2/E2F1/E2F2/HRAS/CDK4/CDH1/FGFR3	1.59389108229317
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/911	19/9376	2.16673406898145	GCSH/DHTKD1/GLDC/PDHA1	1.66998169498547
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/911	27/9376	1.90592348660406	ELOVL6/ELOVL2/TECR/FADS1/SCD	1.54640116000591
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/911	35/9376	1.76434059902776	TPI1/PFKP/ALDOA/AKR1B1/ALDOC/PFKL	1.48612592357296
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	26/911	214/9376	1.25042830616453	CCNB1/CALR/CDK1/CCNB2/CALM1/CHEK1/HLA-G/WEE1/PDIA3/RAC3/CALM3/CDC25C/GNAI1/HRAS/PAK4/CFL1/AP1M2/CUL1/AKT1/CFL2/MAPK12/GNAI3/GNG11/RBX1/GNG4/PXN	1.2157002457131
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/911	14/9376	2.2054257487847	B4GALT4/ST3GAL1/B4GALT1	1.4806469248816
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/911	110/9376	1.30988923261152	ID1/LRRC32/ID3/TFDP1/BMP4/TF/TGFB1/CUL1/BMP7/RBL1/E2F4/RBX1/HDAC1/PPP2R1B	1.07247709737414
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/911	23/9376	1.78991075263685	ACAT2/FDPS/ICMT/HMGCR	1.24422184481723
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/911	57/9376	1.44448937932097	ACAT2/ELOVL6/ELOVL2/TECR/CPT1C/FADS1/SCD/ACACA	1.10419431235504
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/911	232/9376	1.19777432908134	DIAPH3/PFN1/ARPC1A/EZR/RAC3/RDX/ACTG1/ACTN4/ACTN1/PPP1CA/ENAH/ARPC5L/MYH10/MYL9/MYL12B/ACTB/HRAS/ARPC5/PAK4/CFL1/FGFR4/VCL/AKT1/CFL2/MYL12A/FGFR3/PXN	1.00063836311514
NA	NA	hsa04517	IgSF CAM signaling	34/911	299/9376	1.17032626133948	TUBA1B/TUBB/JAM3/TUBA1C/TUBB4B/TUBB6/ARPC1A/EZR/SPTBN1/RDX/ACTG1/APP/ACTN4/ACTN1/ARPC5L/MYH10/MYL9/GRB2/MYL12B/ACTB/ARPC5/PAK4/DYNLL2/MYL6B/VCL/MPDZ/ROBO1/AKT1/MAPK12/CNTNAP2/CDH1/CLMP/MYL12A/PXN	0.981922893404048
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/911	75/9376	1.37226491035492	TOP2A/BIRC5/GSTP1/MSH2/BRCA1/MSH6/GSTA4/MGST3/AKT1/GSTA2	1.061815978836
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/911	93/9376	1.32799830034347	CCNE1/CKS1B/SKP2/CKS2/CCNE2/CDK2/E2F1/LAMA4/E2F2/TRAF4/AKT1/CDK4	1.04279811573931
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/911	149/9376	1.24332726777124	NDUFA6/NDUFV2/GNAI1/NDUFC1/NDUFB11/NDUFC2/NDUFA4/NDUFS5/NDUFB4/NDUFB10/NDUFA11/NDUFA12/NDUFV3/MAPK12/GNAI3/GNG11/GNG4/MT-ND6	0.982166233074936
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/911	76/9376	1.35420879311341	CALM1/EZR/ACTG1/CALM3/GAST/GNAI1/ACTB/GNAS/GNAI3/ATP1B2	1.017082087018
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/911	50/9376	1.44087815587267	ALDH7A1/SRM/CKMT1A/ODC1/P4HA2/GAMT/CKB	1.02538562212598
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/911	77/9376	1.33662166593012	RAD51/RALBP1/RAC3/BRCA2/E2F1/E2F2/TGFB1/RALB/AKT1/CDK4	0.972972687248256
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/911	33/9376	1.55939194358514	GPT2/DHTKD1/AADAT/IDH2/PDHA1	1.05599375125958
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/911	170/9376	1.21082197972493	GSTP1/ACTG1/WNT10B/SMARCC1/GRB2/E2F1/GSTA4/E2F2/SMARCA2/MGST3/ACTB/ACTL6A/AXIN2/HRAS/TGFB1/WNT3A/AKT1/CDK4/WNT7A/GSTA2	0.909989137365535
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/911	78/9376	1.31948549072589	CAV1/ARPC1A/ACTG1/ARPC5L/ACTB/ARPC5/VCL/CTNNA1/CDH1/PXN	0.929469226782895
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/911	200/9376	1.18357848518112	TUBA1B/GAPDH/RPS3/TUBB/NCL/TUBA1C/TUBB4B/TUBB6/MYO1B/ARPC1A/EZR/CLDN7/TMBIM6/CLDN6/MYO10/ACTG1/TMED10/CLDN10/ARPC5L/MYH10/ACTB/ARPC5/MAPK12	0.860877629960581
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/911	34/9376	1.51352747465616	POLR2H/POLR2F/POLR1D/POLR2I/POLR3G	0.984044088235408
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/911	70/9376	1.32325544927082	CAV1/HLA-G/RAC3/SGCB/CD55/ACTG1/ACTB/EIF4G1/DMD	0.890522088349827
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/911	154/9376	1.20295949933711	DHFR/MTHFD1L/UGP2/ALAS2/GGH/NME1/CTPS1/PSAT1/SHMT1/VKORC1/UMPS/AK5/AK2/NME2/AK4/AK1/COQ3/PTS	0.83308349402864
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/911	212/9376	1.16513058426361	CALM1/PFN1/PGF/RAC3/ANGPT4/ACTG1/CALM3/ID1/ENAH/GNAI1/EFNA4/EFNA1/ACTB/HRAS/GNAS/FGFR4/NGFR/RALB/AKT1/MAPK12/CDH1/GNAI3/FGFR3/PRKD3	0.797782036551483
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/911	89/9376	1.27204331577844	TUBA1B/TUBB/CDK1/TUBA1C/TUBB4B/TUBB6/GNAI1/GRB2/HRAS/GNAS/GNAI3	0.845914921161662
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/911	28/9376	1.47028383252313	DHFR/GGH/AKR1B1/PTS	0.817543854057599
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/911	37/9376	1.39080903076512	TPM3/TPR/HRAS/PPARG/CDH1	0.781351788497657
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/911	248/9376	1.1204985659148	TUBA1B/GAPDH/RPS3/TUBB/TUBA1C/PFN1/TUBB4B/HSP90B1/TUBB6/ARPC1A/HSP90AB1/ACTG1/TXN2/ARPC5L/MYL9/MYL12B/CSE1L/FBXO22/ACTB/HRAS/ARPC5/DYNLL2/AKT1/PIK3C2G/MAPK12/ANXA2/MYL12A	0.63088652061117
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/911	122/9376	1.18104766874809	CCNA2/LEP/PFKP/EIF4EBP1/PPARG/CPT1C/AKT1/SCD/ACACA/CAB39L/PFKL/EEF2/HMGCR/PPP2R1B	0.660297191775966
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	14/911	122/9376	1.18104766874809	PFKP/SLC2A1/ACTG1/BMP4/ACTB/HRAS/MED12L/AKT1/PLCD4/PFKL/SLC16A2/MED4/ATP1B2/HDAC1	0.660297191775966
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/911	144/9376	1.14355409196243	WNT10B/ID1/LIFR/GRB2/ID3/DLX5/BMP4/AXIN2/HRAS/FGFR4/WNT3A/AKT1/MAPK12/RIF1/FGFR3/WNT7A	0.569482352003053
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/911	12/9376	1.71533113794365	VKORC1/COQ3	0.813389189460935
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/911	155/9376	1.12879855529195	CCNE1/CYP11A1/CCNE2/WNT10B/CDK2/GNAI1/E2F1/E2F2/AXIN2/GNAS/WDR5/WNT3A/HSD3B1/CDK4/GNAI3/CDKN2C/WNT7A	0.530419125515447
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/911	87/9376	1.18298699168528	BIRC5/RAC3/MSH2/GRB2/MSH6/AXIN2/HRAS/TGFB1/RALB/AKT1	0.562505415184579
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/911	156/9376	1.121562667117	YWHAE/CLDN7/CLDN6/YWHAQ/CLDN10/CDK2/GRB2/E2F1/E2F2/EIF3E/HRAS/YWHAB/AKT1/YWHAZ/CDK4/EIF2S1/PPP2R1B	0.502259782405108
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	15/911	137/9376	1.12685987164182	TUBA1B/BIRC5/LMNB1/TUBA1C/LMNB2/CTSV/ACTG1/ACTB/CASP6/HRAS/DFFA/PARP1/PARP2/AKT1/EIF2S1	0.490685713057444
NA	NA	hsa04981	Folate transport and metabolism	4/911	31/9376	1.32799830034347	TYMS/ABCG2/DHFR/SHMT1	0.600059247127986
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/911	253/9376	1.05767453564905	RPS27A/PFN1/BNIP3/U2AF1/CBX3/ARPC1A/UBA52/ACTG1/VDAC1/ACTN4/ACTN1/ARPC5L/MYL9/MYL12B/ACTB/ARPC5/VCL/UBE2N/CUL1/AKT1/GLMN/PLCD4/MAPK12/MYL12A/RBX1/PXN	0.305075179323456
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/911	63/9376	1.14355409196243	ACAT2/EZH2/ALDH7A1/DHTKD1/AADAT/PLOD1/SMYD2	0.375035513947709
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/911	93/9376	1.10666525028623	CGA/CALM1/CALM3/MMP2/GRB2/HRAS/GNAS/MAPK12/MMP14/MAP3K4	0.33911859267826
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/911	133/9376	1.08336703449073	CCNB1/CCNB2/BNIP3/SKP2/PLK1/CDK2/PRMT1/GRB2/PLK4/HRAS/TGFB1/CSNK1E/AKT1/MAPK12	0.317647208142336
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/911	154/9376	1.06929733274409	TPM4/CALM1/TPM2/CALM3/TPM1/PPP1CA/MYL4/GNAI1/TPM3/GNAS/AKT1/SLC8A3/MAPK12/GNAI3/ATP1B2/PPP2R1B	0.284443272070887
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/911	105/9376	1.0782081438503	TPM4/TPM2/SGCB/ACTG1/TPM1/TPM3/ACTB/GNAS/TGFB1/SLC8A3/DMD	0.26437152922251
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/911	106/9376	1.06803636890831	CCNE1/HSP90B1/GSTP1/CCNE2/HSP90AB1/CDK2/GRB2/E2F1/E2F2/HRAS/AKT1	0.231092333696687
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/911	86/9376	1.07706838894136	DSC2/DSP/SGCB/ACTG1/DSG2/ACTB/CTNNA1/SLC8A3/DMD	0.235531498174743
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/911	76/9376	1.08336703449073	CALM1/CALM3/GRB2/E2F1/E2F2/HRAS/AKT1/CDK4	0.23938174059158
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/911	36/9376	1.14355409196243	PYGL/UGP2/GYG2/PGM1	0.283090134111622
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/911	36/9376	1.14355409196243	GALNT1/GALNT2/C1GALT1/ST3GAL1	0.283090134111622
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/911	77/9376	1.06929733274409	GRB2/E2F1/E2F2/HRAS/TGFB1/AKT1/CDK4/HDAC1	0.200297303718874
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/911	139/9376	1.03660298983645	CALM1/HSP90B1/KRT18/KRT19/HSP90AB1/CALM3/MMP2/GNAI1/GRB2/HRAS/GNAS/AKT1/GNAI3/TFF1	0.142623087902755
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/911	37/9376	1.1126472246121	GNPNAT1/UGP2/PGM1/CMAS	0.225217698392591
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/911	37/9376	1.1126472246121	HBA2/HBA1/LAMA4/THOP1	0.225217698392591
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/911	150/9376	1.02919868276619	CCNE1/CCNE2/WNT10B/CDK2/GRB2/E2F1/E2F2/AXIN2/HRAS/TGFB1/WNT3A/CTNNA1/AKT1/CDH1/WNT7A	0.118258811359583
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/911	99/9376	1.03959462905676	MMP2/GRB2/E2F1/E2F2/HRAS/GNAS/AKT1/MAPK12/CDK4/CDKN2C	0.129921624760447
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/911	99/9376	1.03959462905676	TPM4/TPM2/SGCB/ACTG1/TPM1/TPM3/ACTB/TGFB1/SLC8A3/DMD	0.129921624760447
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/911	203/9376	1.01398885001595	PGF/CAV1/RAC3/ACTG1/ACTN4/ACTN1/PPP1CA/MYL9/GRB2/LAMA4/MYL12B/ACTB/HRAS/COL9A3/PAK4/CCND3/VCL/AKT1/MYL12A/PXN	0.0661006425969513
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/911	59/9376	1.0466427282368	GRB2/AXIN2/HRAS/CTNNA1/AKT1/CDH1	0.117897134289605
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/911	28/9376	1.10271287439235	ELOVL6/ELOVL2/TECR	0.178556593667131
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/911	28/9376	1.10271287439235	B4GALT4/ST3GAL4/B4GALT1	0.178556593667131
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/911	163/9376	1.01025637572141	BIRC5/CCNE1/CCNA2/PCNA/CCNE2/YWHAQ/CDK2/GRB2/E2F1/E2F2/HRAS/TGFB1/YWHAB/AKT1/YWHAZ/MAPK12	0.0433329777690919
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/911	49/9376	1.05020273751652	GALNT1/GALNT2/GXYLT1/C1GALT1/B4GALT1	0.115580826744431
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/911	70/9376	1.02919868276619	SLC2A1/GRB2/HRAS/PAK4/TGFB1/AKT1/RBX1	0.0804381550648774
NA	NA	hsa04518	Integrin signaling	15/911	154/9376	1.00246624944759	PGF/FERMT2/RAC3/ACTG1/ACTN4/ACTN1/LAMA4/ACTB/COL9A3/CCND3/VCL/TGFB1/AKT1/CDH1/PXN	0.0101231610920108
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/911	50/9376	1.02919868276619	HBA2/HBA1/GYPB/GYPA/TGFB1	0.067909714043798
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/911	61/9376	1.01232657321265	MT1E/TF/SLC8A3/SLC6A19/MT1A/ATP1B2	0.0316845244234455
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/911	83/9376	0.991998730377052	AURKB/CBX3/EZH2/TFDP1/RBBP7/EED/WDR5/HDAC1	-0.0240188012443147
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/911	30/9376	1.02919868276619	IDH2/MDH2/PDHA1	0.0525463245794007
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/911	105/9376	0.980189221682087	RPS27A/BNIP3/TOMM20/UBA52/VCP/E2F1/TOMM40/PHB2/HRAS/EIF2S1	-0.0669675241113029
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/911	148/9376	0.973566321535586	BRCA1/WNT10B/BRCA2/GRB2/E2F1/E2F2/AXIN2/HRAS/HEY1/WNT3A/AKT1/CDK4/HEYL/WNT7A	-0.106332497177322
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/911	138/9376	0.969534991011629	RPS6/PYGL/CALM1/CALM3/PPP1CA/GRB2/SH2B2/PKLR/HRAS/EIF4EBP1/AKT1/ACACA/EIF4E2	-0.118272348430948
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/911	20/9376	1.02919868276619	UGP2/CMAS	0.0428809596839168
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/911	42/9376	0.980189221682087	ACAT2/ALDH7A1/DHTKD1/AADAT	-0.0422108046121242
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/911	75/9376	0.960585437248445	CGA/HSPA5/HSP90B1/PDIA4/GPX8/GNAS/ATP1B2	-0.112422662905655
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/911	140/9376	0.955684491140035	RPS6/CALM1/CALM3/TFAM/MYL4/GNAI1/HRAS/AKT1/SLC8A3/CDH1/GNAI3/GNG11/GNG4	-0.173304221471116
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/911	43/9376	0.957394123503433	ACAT2/ADH5/ALDH7A1/CPT1C	-0.0918595776858626
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/911	204/9376	0.95856740061557	RPS6/CAV1/EZR/RDX/ACTG1/WNT10B/GPC1/PPP1CA/MMP2/GRB2/ACTB/HRAS/TGFB1/WNT3A/AKT1/MAPK12/ANK1/PXN/WNT7A	-0.196271204143819
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/911	32/9376	0.964873765093304	LDHA/LDHB/ACACA	-0.0652937363242091
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/911	183/9376	0.956086208034167	RAN/POP7/NOP56/FBL/NHP2/NOP58/GNL3/MPHOSPH10/TCOF1/RRP7A/RBM28/DKC1/GTPBP4/EMG1/XPO1/UTP6/XRN2	-0.196801860785022
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/911	130/9376	0.950029553322638	MMP2/GNAI1/GRB2/HRAS/GNAS/TGFB1/AKT1/MAPK12/RLN2/GNAI3/GNG11/GNG4	-0.188208532578208
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/911	21/9376	0.980189221682087	CHSY1/DSEL	-0.0298140266390065
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/911	184/9376	0.950890087338329	RAC3/ENAH/GNAI1/MYL9/EFNA4/MYL12B/EFNA1/HRAS/EPHB4/PAK4/CFL1/ROBO1/BMP7/CFL2/GNAI3/MYL12A/BOC	-0.2207010558689
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	21/911	227/9376	0.952122129431278	CALR/CALM1/HLA-G/PDIA3/RAC3/CALM3/GNAI1/GRB2/E2F1/E2F2/HRAS/GNAS/CCL3L1/EIF4EBP1/AKT1/MAPK12/CDK4/GNAI3/GNG11/GNG4/PXN	-0.239547855126995
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/911	333/9376	0.958112887860418	CCNE1/CCNA2/HLA-G/PKM/CCNE2/WNT10B/CDK2/TUBG1/GRB2/E2F1/LAMA4/AXIN2/HRAS/GNAS/HEY1/ATP6V1B1/EIF4EBP1/COL9A3/CCND3/WNT3A/ATP6V1C2/DLG3/AKT1/CDK4/HEYL/RBL1/PSMC1/PXN/HDAC1/WNT7A/PPP2R1B	-0.255315755708975
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/911	44/9376	0.935635166151083	CDK7/TAF15/MNAT1/TAF9	-0.140384439106384
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/911	217/9376	0.948570214531052	BIRC5/CDC6/HSP90B1/KPNA2/PTGES3/CDC25A/HSP90AB1/GNAI1/GRB2/E2F1/GSTA4/MGST3/KPNB1/HRAS/GNAS/EIF4EBP1/CCND3/AKT1/GNAI3/GSTA2	-0.251450148021947
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/911	78/9376	0.92363984350812	CALM1/CALM3/GNAI1/CFL1/CFL2/MAPK12/GNAI3	-0.222152234363668
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/911	34/9376	0.908116484793698	CUL1/CSNK1E/RBX1	-0.176071260852381
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/911	101/9376	0.917107737118388	CALM1/CALM3/WNT10B/GNAI1/HRAS/GNAS/WNT3A/GNAI3/WNT7A	-0.274757191733044
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/911	23/9376	0.894955376318427	B4GALT1/POMK	-0.165460230828513
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/911	80/9376	0.900548847420417	RPS6/GRB2/HRAS/EIF4EBP1/AKT1/FGFR3/EIF4E2	-0.293047554919813
NA	NA	hsa04519	Cadherin signaling	37/911	404/9376	0.942582952038343	DSC2/DSP/YWHAE/MYO1B/ARPC1A/KRT18/RAC3/KRT19/LIMA1/YWHAQ/ACTG1/KRT8/DSG2/WNT10B/CDH5/ACTN4/KRT7/ACTN1/PPP1CA/ENAH/TEAD4/ARPC5L/ACTB/AXIN2/HRAS/ARPC5/DSC3/VCL/WNT3A/YWHAB/MPDZ/CTNNA1/YWHAZ/MAPK12/CDH1/WNT7A/PKP3	-0.387006496600945
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/911	103/9376	0.899299819892788	CALR/GNAI1/GNAS/CCL3L1/TGFB1/AKT1/MAPK12/GNAI3/PPP2R1B	-0.337108788822452
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/911	158/9376	0.91194819991941	RPS6/SKP2/WNT10B/GRB2/HRAS/ATP6V1B1/EIF4EBP1/WNT3A/ATP6V1C2/SLC7A5/AKT1/CAB39L/WNT7A/EIF4E2	-0.366167483973931
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/911	180/9376	0.914843273569948	CALR/SRSF7/HLA-G/PDIA3/ALYREF/SRSF2/SRSF3/SRSF9/PPP1CA/SRPK1/SRSF4/EIF4EBP1/SRSF1/EIF2B2/AKT1/EIF2S1	-0.378431321898814
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/911	59/9376	0.87220227353067	CGA/GNAI1/GNAS/AKT1/GNAI3	-0.323029683061546
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/911	36/9376	0.857665568971826	UGP2/AKR1B1/DCXR	-0.280684950304387
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/911	82/9376	0.878584241385773	CALR/HSPA5/HSPA2/HLA-G/PDIA3/HSP90AB1/NFYB	-0.362253003768316
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/911	48/9376	0.857665568971826	ACAT2/ALDH7A1/HSD17B10/OXCT1	-0.324315469895274
NA	NA	hsa03272	Virion - Hepatitis viruses	4/911	48/9376	0.857665568971826	CLDN7/CLDN6/CLDN10/EPCAM	-0.324315469895274
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/911	71/9376	0.869745365717908	CGA/GRB2/HRAS/AKT1/MAPK12/ELF5	-0.361406130296401
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/911	60/9376	0.857665568971826	RAC3/HRAS/AKT1/MAPK12/PXN	-0.362829174213411
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/911	60/9376	0.857665568971826	GNAI1/HRAS/GNAS/GNAI3/PPP2R1B	-0.362829174213411
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/911	12/9376	0.857665568971826	NGFR	-0.161845726189414
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/911	37/9376	0.834485418459074	GPT2/PPAT/NIT2	-0.330916391712475
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/911	73/9376	0.845916725561253	E2F1/E2F2/HRAS/AKT1/CDK4/CDH1	-0.433547577765483
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/911	73/9376	0.845916725561253	GRB2/E2F1/E2F2/HRAS/AKT1/CDK4	-0.433547577765483
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/911	38/9376	0.812525275868046	GNPNAT1/UGP2/PGM1	-0.379873442257527
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/911	62/9376	0.82999893771467	HEY1/SNW1/HEYL/TLE1/HDAC1	-0.440565726581835
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/911	362/9376	0.909788890843042	RPS6/CCNE1/PGF/HSP90B1/YWHAE/CCNE2/ANGPT4/HSP90AB1/YWHAQ/BRCA1/CDK2/CDC37/EFNA4/GRB2/LAMA4/EFNA1/HRAS/EIF4EBP1/COL9A3/FGFR4/CCND3/NGFR/YWHAB/AKT1/YWHAZ/CDK4/PKN3/FGFR3/GNG11/GNG4/PPP2R1B/EIF4E2	-0.574231320154744
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/911	63/9376	0.816824351401739	WNT10B/BMP4/AXIN2/WNT3A/WNT7A	-0.478546954500821
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/911	155/9376	0.863198895223257	TUBA1B/CALR/TUBB/TUBA1C/TUBB4B/HLA-G/TUBB6/ACTG1/ACTB/ATP6V1B1/SEC61G/ATP6V1C2/EEA1	-0.56337528166173
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/911	27/9376	0.762369394641623	ACAT2/OXCT1	-0.405632759513285
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	11/911	133/9376	0.851216955671286	CALM1/CALM3/PPP1CA/GNAI1/GNAS/AKT1/MAPK12/GNAI3/GNG11/GNG4/PPP2R1B	-0.566896962793971
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/911	52/9376	0.791691294435532	CGA/CYP11A1/GNAS/HSD3B1	-0.494127819066128
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/911	53/9376	0.776753722842408	RAB11A/GNAS/SLC8A3/ATP1B2	-0.534657500198942
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/911	28/9376	0.735141916261565	ATP6V1B1/ATP6V1C2	-0.460430666723336
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/911	15/9376	0.686132455177461	ST3GAL1	-0.399082112624344
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/911	29/9376	0.709792195011166	TEAD4/CSNK1E	-0.513456092540351
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/911	29/9376	0.709792195011166	CALM1/CALM3	-0.513456092540351
Organismal Systems	Immune system	hsa04611	Platelet activation	10/911	126/9376	0.816824351401739	ACTG1/PPP1CA/GNAI1/MYL12B/ACTB/GNAS/AKT1/MAPK12/GNAI3/MYL12A	-0.679068350450075
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/911	173/9376	0.832877546747207	KPNA2/FDPS/ACTG1/RAB11A/VDAC1/ACTB/SLC25A4/DNAJC3/CCND3/XPO1/AKT1/CDK4/EIF2S1/TMPRSS4	-0.727820842413229
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/911	68/9376	0.756763737328082	CCNA2/GRB2/HRAS/EIF4EBP1/AKT1	-0.660367872621755
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/911	16/9376	0.643249176728869	MIF	-0.468509494493814
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/911	16/9376	0.643249176728869	ST3GAL1	-0.468509494493814
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/911	56/9376	0.735141916261565	BNIP3/HSPD1/VCP/SAR1A	-0.65212467812783
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/911	69/9376	0.745796146932022	RAC3/GRB2/HRAS/AKT1/MAPK12	-0.695237457887724
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/911	69/9376	0.745796146932022	CALM1/CALM3/GNAI1/GNAS/GNAI3	-0.695237457887724
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/911	69/9376	0.745796146932022	CALM1/CALM3/PPP1CA/GNAS/HDAC1	-0.695237457887724
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/911	44/9376	0.701726374613312	RAB11A/GNAS/DYNLL2	-0.650556726339509
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/911	17/9376	0.605410989862465	SEPHS1	-0.534178086283488
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/911	17/9376	0.605410989862465	MYH10	-0.534178086283488
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/911	154/9376	0.801972999558071	CALM1/ACTG1/CALM3/PPP1CA/GNAI1/MYL9/ACTB/HRAS/GNAS/MYL6B/GNAI3/EEF2	-0.812837171844618
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/911	32/9376	0.643249176728869	BIRC5/NGFR	-0.66313950954275
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/911	120/9376	0.771899012074643	CALM1/YWHAE/CALM3/GRB2/SH2B2/HRAS/NGFR/AKT1/MAPK12	-0.82496868175682
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/911	18/9376	0.571777045981217	ACACA	-0.596548860729734
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/911	97/9376	0.742720698903437	CALM1/CALM3/GNAI1/GNAS/GNAI3/GNG11/GNG4	-0.835548131853734
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	19/911	238/9376	0.821629200527631	CALM1/PGF/RALBP1/RAC3/ANGPT4/CALM3/EFNA4/GRB2/EFNA1/HRAS/PAK4/FGFR4/NGFR/RALB/AKT1/FGFR3/GNG11/GNG4/PLA2G2A	-0.914361657013096
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/911	73/9376	0.704930604634377	GSTP1/ADH5/GSTA4/MGST3/GSTA2	-0.83024339987236
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/911	73/9376	0.704930604634377	RAN/PSIP1/PPIA/XPO1/CPSF6	-0.83024339987236
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/911	98/9376	0.735141916261565	ARPC1A/MYO10/ARPC5L/ARPC5/CFL1/AKT1/CFL2	-0.86463026212292
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/911	98/9376	0.735141916261565	CALM1/CYP11A1/CALM3/GNAS/HSD3B1/PRKD3/ATP1B2	-0.86463026212292
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/911	49/9376	0.630121642509913	GNAI1/GNAS/GNAI3	-0.851564047468675
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/911	125/9376	0.741023051591657	RAC3/GNAI1/HRAS/CERS5/AKT1/ORMDL2/MAPK12/GNAI3/PPP2R1B	-0.956209646474772
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/911	323/9376	0.828457144022321	CCNE1/STMN1/KIF23/EZH2/CDCA5/EZR/IGF2BP1/CCNE2/CDC25A/RDX/BRCA1/TPM1/CDC25C/HNRNPK/EFNA4/GRB2/E2F1/E2F2/EFNA1/HRAS/HMGA2/PAK4/WNT3A/FGFR3/HDAC1/UBE2I	-1.02922181484901
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/911	101/9376	0.713306017758746	MMP2/HRAS/TGFB1/AKT1/PLCD4/MAPK12/CDK4	-0.950284510387565
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/911	103/9376	0.699455415472169	ACTN4/ACTN1/LAMA4/GNAS/VCL/TGFB1/SERPINB9	-1.00611757366726
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/911	37/9376	0.556323612306049	MIF/ADH5	-0.887050481817541
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/911	78/9376	0.659742745362943	TPI1/IMPA2/SYNJ1/PIK3C2G/PLCD4	-0.989899875128043
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/911	91/9376	0.678592538087598	PDE4D/GNAI1/GNAS/GNAI3/GNG11/GNG4	-1.01068784538102
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/911	52/9376	0.593768470826649	VDAC1/VDAC2/VAPB	-0.963619350436621
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/911	79/9376	0.651391571371007	GSTP1/ADH5/GSTA4/MGST3/GSTA2	-1.02073112740151
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/911	166/9376	0.743999047782789	CALM1/CALM3/VDAC1/VDAC2/PPP1CA/GNAI1/MYL9/SLC25A4/AKT1/SLC8A3/GNAI3/ATP1B2	-1.09168452755926
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/911	178/9376	0.751661959323623	RAC3/CACYBP/WNT10B/LGR4/RUVBL1/AXIN2/CCND3/WNT3A/CUL1/CSNK1E/TLE1/RBX1/WNT7A	-1.09733162150401
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/911	22/9376	0.467817583075541	ALDH7A1	-0.819793602105802
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/911	38/9376	0.541683517245364	SFN/ATP1B2	-0.928670575478879
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/911	38/9376	0.541683517245364	UNG/ADA	-0.928670575478879
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/911	67/9376	0.614446974785786	CALM1/CALM3/PPP1CA/HRAS	-1.03896602685742
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/911	23/9376	0.447477688159213	GPT2	-0.870301268651382
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/911	23/9376	0.447477688159213	THOP1	-0.870301268651382
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/911	23/9376	0.447477688159213	ATP1B2	-0.870301268651382
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/911	157/9376	0.721094618498605	CALR/SLC2A1/BSG/ODC1/PPARG/CPT1C/TGFB1/TYRO3/MAPK12/ATP11A/SLC16A1	-1.15610201538225
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/911	134/9376	0.691252846634009	CALM1/CALD1/CALM3/PPP1CA/MYH10/MYL9/GNAS/MYL6B/PLA2G2A	-1.18087444613334
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/911	70/9376	0.588113533009252	LEP/SLC2A1/CPT1C/AKT1	-1.13468774486255
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/911	70/9376	0.588113533009252	GSTP1/GSTA4/MGST3/GSTA2	-1.13468774486255
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/911	56/9376	0.551356437196174	CUL1/CSNK1E/BOC	-1.10463511197378
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/911	71/9376	0.579830243811939	JAM3/ATP6V1B1/ATP6V1C2/MAPK12	-1.16580823775256
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/911	98/9376	0.630121642509913	CALM1/IMPA2/CALM3/SYNJ1/PIK3C2G/PLCD4	-1.20746936123755
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/911	42/9376	0.490094610841043	VDAC2/TF	-1.08645487860494
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/911	99/9376	0.623756777434055	CALM1/CALM3/PPP1CA/GNAS/MAPK12/ASIC4	-1.23456468580124
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/911	99/9376	0.623756777434055	RAC3/GRB2/HRAS/EIF4EBP1/SLC44A2/AKT1	-1.23456468580124
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/911	138/9376	0.67121653223882	ARPC1A/RAC3/ACTG1/ARPC5L/ACTB/ARPC5/AKT1/MAPK12/PXN	-1.27641494779238
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/911	86/9376	0.598371327189646	GRB2/HRAS/EIF4EBP1/PAK4/AKT1	-1.22743195123658
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/911	26/9376	0.395845647217766	PLA2G2A	-1.0119524887666
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/911	26/9376	0.395845647217766	PKLR	-1.0119524887666
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/911	43/9376	0.478697061751717	ACAT2/PLA2G2A	-1.12394513836009
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/911	44/9376	0.467817583075541	HLA-G/HSPD1	-1.16072901357263
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/911	191/9376	0.700501721254476	CALM1/CALM3/PPP1CA/GNAI1/GRB2/HAT1/SLC29A1/HRAS/GNAS/GNAI3/GNG11/GNG4/HDAC1	-1.37183784484152
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/911	115/9376	0.626468763422899	APP/GNAI1/HRAS/GNAS/GNAI3/GNG11/GNG4	-1.3221424493319
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/911	115/9376	0.626468763422899	NACA/PDE4D/GNAI1/GNAS/GCM1/GNAI3/MMP14	-1.3221424493319
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/911	45/9376	0.457421636784974	ABCG2/ABCA7	-1.19683967831078
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/911	90/9376	0.571777045981217	HRAS/EIF4EBP1/PPARG/AKT1/EIF4E2	-1.33908517985219
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/911	90/9376	0.571777045981217	ABCG2/SLC2A1/GNAS/HMGCR/ATP1B2	-1.33908517985219
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/911	76/9376	0.541683517245364	SLC27A6/PPARG/CPT1C/SCD	-1.31601895226127
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/911	62/9376	0.497999362628802	HRAS/AKT1/HDAC1	-1.30095819740693
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/911	91/9376	0.565493781739665	RAC3/IFITM1/GRB2/HRAS/AKT1	-1.36633465484968
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/911	47/9376	0.437956886283486	PKM/PKLR	-1.26716263694263
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/911	196/9376	0.682631779385739	RPS27A/CALM1/HLA-G/UBA52/CALM3/E2F1/E2F2/HRAS/AKT1/MAPK12/CDK4/GNG11/GNG4	-1.47299569457744
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/911	63/9376	0.490094610841043	PTGES3/PTGDS/PLA2G2A	-1.33212942294935
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/911	30/9376	0.34306622758873	PLA2G2A	-1.18222645551198
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/911	48/9376	0.428832784485913	AKT1/ATP1B2	-1.30143045888566
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/911	94/9376	0.547446107854357	HSP90B1/HSP90AB1/SRSF1/TRAF4/MAPK12	-1.4465877882849
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/911	31/9376	0.331999575085868	ALDH7A1	-1.22207899137099
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/911	31/9376	0.331999575085868	ALDH7A1	-1.22207899137099
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/911	65/9376	0.475014776661319	ALDH7A1/AKR1B1/AGPAT5	-1.39327530651719
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/911	65/9376	0.475014776661319	CYP11A1/GNAS/HSD3B1	-1.39327530651719
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/911	65/9376	0.475014776661319	CGA/HRAS/AKT1	-1.39327530651719
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/911	122/9376	0.590523834374044	GRB2/HRAS/PAK4/AKT1/MAPK12/CDK4/PPP2R1B	-1.49339654098619
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/911	122/9376	0.590523834374044	GNAI1/GRB2/HRAS/GNAS/AKT1/MAPK12/GNAI3	-1.49339654098619
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/911	136/9376	0.605410989862465	CCNE1/CCNE2/CDK2/EIF3H/CCND3/AKT1/CDK4/EIF2S1	-1.5205818397079
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/911	66/9376	0.467817583075541	CYP11A1/SRD5A3/HSD3B1	-1.42327556797164
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/911	216/9376	0.66707322031142	HSPA5/CALM1/HSPA2/HSP90B1/HSPD1/HSP90AB1/CALM3/CASP6/HRAS/CCL3L1/PPARG/AKT1/MAPK12/EIF2S1	-1.62389974714362
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/911	83/9376	0.495999365188526	IDH2/PXMP2/PRDX5/PXMP4	-1.51294627540429
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/911	83/9376	0.495999365188526	POLR2H/POLR2F/POLR1D/POLR3G	-1.51294627540429
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/911	112/9376	0.551356437196174	GNAI1/LAMA4/TGFB1/AKT1/MAPK12/GNAI3	-1.56690448778577
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/911	115/9376	0.536973225791056	GNAI1/HRAS/AKT1/GNAI3/GNG11/GNG4	-1.63891876612172
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/911	54/9376	0.381184697320811	CGA/HLA-G	-1.49601077280144
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/911	144/9376	0.571777045981217	ADH5/ALDH7A1/TRA2B/CPT1C/AKT1/SCD/ACACA/MAPK12	-1.69877021060554
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/911	103/9376	0.499611011051549	COL9A3/SLC8A3/SLC6A19/ATP1B2/COL21A1	-1.67512635851208
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/911	89/9376	0.462561205737614	GNAI1/GNAI3/GNG11/GNG4	-1.67115848436412
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/911	38/9376	0.270841758622682	NT5DC4	-1.47746770870023
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/911	105/9376	0.490094610841043	CALM1/CALM3/HRAS/AKT1/MAPK12	-1.72366279078037
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/911	39/9376	0.263897098145177	HLA-G	-1.51111841955632
NA	NA	hsa04382	Cornified envelope formation	13/911	217/9376	0.616570639445184	DSP/KRT18/KRT19/CLDN7/CLDN6/PADI1/KRT8/DSG2/CLDN10/KRT7/S100A11/PKP3/PPP2R1B	-1.87466015244571
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/911	93/9376	0.442666100114491	CALM1/CALM3/GNAS/ATP1B2	-1.7719199765049
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/911	109/9376	0.472109487507427	PYGL/SLC2A1/PPP1CA/SLC27A6/AKT1	-1.81852329906227
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/911	95/9376	0.433346813796291	CCL3L1/ATP6V1B1/TGFB1/ATP6V1C2	-1.821013212462
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/911	168/9376	0.551356437196174	HMGB1/PYGL/HSP90AB1/VDAC1/PPIA/VDAC2/SLC25A4/DNM1L/PARP1	-1.92488492744298
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/911	187/9376	0.550373627147696	YWHAE/HSP90AB1/VDAC1/TXN2/SUGT1/VDAC2/DNM1L/TRIP6/MAPK12/BRCC3	-2.03736949754894
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/911	45/9376	0.228710818392487	HLA-G	-1.70133856892094
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/911	160/9376	0.514599341383095	JAM3/HLA-G/CLDN7/CLDN6/CDH5/CLDN10/CNTNAP2/CDH1	-2.03151701923169
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/911	116/9376	0.443620121881979	GNAI1/GNAS/GNAI3/GNG11/GNG4	-1.97799988387908
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/911	46/9376	0.223738844079607	ALAS2	-1.73131979303587
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/911	102/9376	0.403607326574977	RAB11A/GNAS/ATP1B2/PLA2G2A	-1.98669036315142
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/911	86/9376	0.359022796313788	SLC2A1/GNAS/ATP1B2	-1.95891367594224
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/911	193/9376	0.533263566200099	RAC3/GNAI1/GRB2/HRAS/CCL3L1/AKT1/GNAI3/GNG11/GNG4/PXN	-2.14926225316207
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/911	88/9376	0.350863187306656	TFPI/CD55/PROCR	-2.00700205394475
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/911	195/9376	0.527794196290354	HMGB1/ACTG1/VDAC1/VDAC2/HAT1/ACTB/SLC25A4/AKT1/MAPK12/HDAC1	-2.18592359539355
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/911	89/9376	0.34692090430321	HMMR/LAMA4/COL9A3	-2.03074039943923
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/911	50/9376	0.205839736553238	TGFB1	-1.84704210212057
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/911	90/9376	0.34306622758873	HRAS/AKT1/MAPK12	-2.05428100134431
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/911	51/9376	0.201803663287488	PLA2G2A	-1.87500203556827
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/911	226/9376	0.546477176690013	CGA/CALM1/RAC3/PDE4D/CALM3/PPP1CA/GNAI1/MYL9/GNAS/AKT1/GNAI3/ATP1B2	-2.2639882346269
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/911	143/9376	0.431831615146654	SNRPB/SNRPD1/SNRPD3/SSB/ACTN4/ACTN1	-2.24597547989016
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/911	55/9376	0.187127033230217	CERS5	-1.98337172188151
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/911	78/9376	0.263897098145177	TGFB1/MAPK12	-2.14152133627461
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	13/911	250/9376	0.535183315038419	CAV1/HLA-G/ARPC1A/RAB11A/ARPC5L/HRAS/ARPC5/SNX5/FGFR4/SNF8/FGFR3/EEA1/VPS25	-2.44367151580656
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/911	79/9376	0.260556628548403	ATP6V1B1/ATP6V1C2	-2.16510217254279
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/911	149/9376	0.414442422590412	AGPAT5/GRB2/HRAS/GNAS/RALB/AKT1	-2.36354472443898
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/911	181/9376	0.454894445421521	CALM1/HSPD1/CALM3/NFYB/TGFB1/AKT1/MAPK12/EEA1	-2.42926768790863
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/911	119/9376	0.345949137064266	DNM1L/AKT1/MAPK12/MMP14	-2.35548974218217
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/911	169/9376	0.426295312388363	HMGB1/RPS27A/BNIP3/UBA52/HRAS/AKT1/EIF2S1	-2.46890298416537
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	16/911	300/9376	0.548905964141969	PGF/STMN1/RAC3/ANGPT4/EFNA4/GRB2/EFNA1/HRAS/FGFR4/TGFB1/NGFR/PPP5C/AKT1/MAPK12/FGFR3/MAP3K4	-2.60502451304386
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/911	201/9376	0.460835231089339	CCNA2/FUS/TAF15/PPARG/HMGA2/NGFR/MYCN/CDKN2C/HDAC1	-2.5348241942503
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/911	105/9376	0.294056766504626	PARP1/CARD10/UBE2I	-2.38634089744799
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/911	142/9376	0.362393902382462	GRB2/PPARG/TGFB1/AKT1/MAPK12	-2.51149920049706
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/911	66/9376	0.155939194358514	TGFB1	-2.25736718152887
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/911	109/9376	0.283265692504456	CCL3L1/AKT1/MAPK12	-2.46906888184744
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/911	109/9376	0.283265692504456	HSP90AB1/TGFB1/MAPK12	-2.46906888184744
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/911	68/9376	0.151352747465616	ADH5	-2.30401246346369
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/911	133/9376	0.309533438425922	HLA-G/RAC3/GRB2/HRAS	-2.63083336164535
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/911	168/9376	0.367570958130782	LEP/LIFR/GRB2/HRAS/CCND3/AKT1	-2.71340821823752
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/911	72/9376	0.142944261495304	MAPK12	-2.39481411906734
NA	NA	hsa04081	Hormone signaling	9/911	219/9376	0.422958362780626	CGA/LEP/GAST/GNAI1/GNAS/GNAI3/SLC16A2/GNG11/GNG4	-2.83454885818447
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/911	99/9376	0.207918925811352	KRT18/KRT19	-2.59905099636294
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/911	100/9376	0.205839736553238	GYPA/CD55	-2.61914250386526
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/911	254/9376	0.445715964977484	CALM1/CALM3/VDAC1/VDAC2/GNAS/SLC25A4/FGFR4/ASPH/SLC8A3/PLCD4/FGFR3	-2.93789005875996
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/911	104/9376	0.197922823608883	AGPAT5/PLA2G2A	-2.69822065202809
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/911	93/9376	0.110666525028623	MAPK12	-2.82743926109648
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/911	100/9376	0.102919868276619	CCL3L1	-2.95857248280374
NA	NA	hsa04082	Neuroactive ligand signaling	5/911	199/9376	0.258592633860852	GNAI1/GNAS/GNAI3/GNG11/GNG4	-3.46788282148685
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/911	250/9376	0.288175631174533	LAPTM4B/CTSV/CTSE/SLC29A1/ATP6V1B1/AP1M2/ATP6V1C2	-3.74226010088159
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/911	298/9376	0.276294948393608	LEP/LIFR/BMP4/CCL3L1/TGFB1/NGFR/ACVRL1/BMP7	-4.16491356051282
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/911	370/9376	0.194713264307117	CGA/LEP/TMEM97/GAL/CHRNA5/PGRMC2/RLN2	-5.184618221219
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/911	449/9376	0.0687660589821509	CALM1/CALM3/SLC8A3	-6.63377206326228