category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	56/863	174/9376	3.49659700856408	HSPA5/PDIA6/CALR/HSP90B1/LMAN1/OSTC/SSR2/SSR3/MAN1A2/PDIA3/SSR4/RRBP1/CANX/PDIA4/UBXN4/STT3B/P4HB/DNAJB11/SEC61G/SEC61B/DNAJC3/XBP1/HERPUD1/LMAN2/RPN2/ERP29/SAR1A/TRAM1/DAD1/DDOST/TUSC3/ERLEC1/TMEM258/STT3A/CKAP4/PRKCSH/MAGT1/HSP90AB1/CRYAB/SEC61A1/GANAB/SSR1/DERL2/SAR1B/SEC24D/EDEM2/SEC23B/SEC63/KRTCAP2/RPN1/ERN1/HYOU1/OS9/EIF2S1/DNAJC10/HSPBP1	10.5835575291057
Genetic Information Processing	Translation	hsa03010	Ribosome	63/863	222/9376	3.08314803795684	RPL29/RPL28/RPL18A/RPS3A/RPS5/RPL7A/RPS6/RPS9/RPS18/RPLP0/RPSA/RPL36/RPL19/RPS2/RPL15/RPS15/RPL5/RPL14/RPS19/RPL8/RPS4X/RPL10/RPL6/RPL39/RPL11/RPL13/RPS13/RPL35A/MRPL11/RPL4/RPS7/RPL3/RPL13A/RPL22/RPL32/RPL27A/RPS27A/RPL37A/RPL12/MRPS15/RPL35/RPL22L1/MRPL23/RPL41/MRPL51/RPS3/RPS16/RPL18/RPL26/MRPS31/MRPL41/MRPL37/RPS23/MRPS9/RSL24D1/MRPL14/MRPL21/MRPL50/MRPS5/MRPL32/MRPL35/MRPL22/MRPL9	10.0009414912997
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	56/863	238/9376	2.55633562810988	RPL29/RPL28/RPL18A/RPS3A/RPS5/RPL7A/RPS6/RPS9/RPS18/RPLP0/RPSA/RPL36/RPL19/RPS2/RPL15/RPS15/RPL5/RPL14/RPS19/RPL8/RPS4X/RPL10/RPL6/CFD/RPL39/RPL11/RPL13/RPS13/RPL35A/RPL4/RPS7/RPL3/RPL13A/RPL22/C1R/RPL32/JUN/ISG15/RPL27A/RPS27A/RPL37A/RPL12/RPL35/RPL22L1/C1S/RPL41/FOS/RPS3/RPS16/RPL18/RPL26/RPS23/MAPK13/PRKCA/RSL24D1/JAK1	7.74311805210566
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	15/863	31/9376	5.25698052554854	HSPA5/SEC11A/SPCS3/SEC61G/SEC61B/SPCS2/SRPRB/SRP19/SRP72/SEC61A1/SEC11C/SEC63/SRP9/SRP68/OXA1L	7.55862112333714
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	37/863	158/9376	2.54420112354606	CCNE1/CCNB1/PTTG1/CCNB2/CDC20/CDK1/MAD2L1/CCNA2/YWHAQ/AURKB/CDT1/SMC1A/CDC6/TTK/STAG2/ORC6/CDK7/PRKDC/PCNA/CCND2/RAD21/BUB3/PLK1/CDK4/DBF4/NDC80/PPP2R1A/PPP2R1B/ESCO2/CDCA5/MCM7/TFDP1/GADD45A/TGFB1/NIPBL/BUB1/ANAPC5	6.23252135233235
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	17/863	44/9376	4.19761929843042	OSTC/MAN1A2/STT3B/RPN2/DAD1/DDOST/TUSC3/TMEM258/STT3A/MAGT1/B4GALT1/ALG2/MGAT1/KRTCAP2/RPN1/MAN2A1/ALG9	6.76885870918448
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	19/863	56/9376	3.68614467803344	OSTC/MAN1A2/STT3B/RPN2/DAD1/DDOST/TUSC3/TMEM258/STT3A/MAGT1/B4GALT1/GANAB/ALG2/MGAT1/KRTCAP2/RPN1/SRD5A3/MAN2A1/ALG9	6.41896750465156
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/863	203/9376	2.24781236264834	CAV1/COL1A1/COL6A2/ACTG1/PPP1CB/COL1A2/COL4A2/COL4A1/COL6A1/LAMA4/FLNB/JUN/COL6A3/ACTN1/BRAF/ITGA5/PPP1CC/GRB2/RAC3/IGF1/PPP1R12A/PARVA/PPP1CA/FYN/LAMA1/CCND2/LAMB1/VCL/PRKCA/CAV2/DIAPH1/ITGA1/XIAP/PDGFRB/MYL9/VASP/COL9A3/FLT4/ROCK1/ITGB5/PIP5K1C/PDGFRA	5.72257279147505
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	45/863	233/9376	2.09827978058375	TPM1/COL1A1/TPM2/ENO1/COL3A1/COL6A2/ACTG1/DCN/COL1A2/COL4A2/DSC2/COL4A1/COL6A1/MYL4/TNNI2/VCAN/COL6A3/NID1/ITGA5/LMNB1/LMNB2/DSP/DIAPH3/SDC4/ATP1A1/SSPN/COL27A1/SPTBN1/COL5A1/FBLN2/SDC1/LAMA1/COL5A2/VCL/LBR/DIAPH1/DSG2/ITGA1/SGCB/MYH9/MYL9/COL9A3/DAAM1/SYNPO2/ITGB5	5.40500759150211
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/863	20/9376	4.88899188876014	SQLE/MSMO1/DHCR24/EBP/DHCR7/HSD17B7/SC5D/LBR/CYP51A1	5.54315021727955
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/863	103/9376	2.42603696745379	COL1A1/COL3A1/COL6A2/COL1A2/COL4A2/COL4A1/COL6A1/COL6A3/SLC3A2/FXYD2/COL18A1/ATP1A1/COL27A1/COL5A1/COL5A2/SLC6A19/SLC1A5/KCNN4/DPP4/KCNE3/COL9A3/COL15A1/COL21A1	4.6332846873041
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/863	23/9376	4.25129729457403	ACAT2/HMGCR/HMGCS1/ACAT1/NUS1/MVD/IDI1/FDPS/HMGCS2	4.97044019705805
NA	NA	hsa04518	Integrin signaling	29/863	154/9376	2.04589848158794	COL1A1/COL6A2/ACTG1/COL1A2/COL4A2/COL4A1/COL6A1/LAMA4/FLNB/COL6A3/ACTN1/ITGA5/RAC3/IGF1/PARVA/LIMS1/LAMA1/CCND2/LAMB1/VCL/ITGA1/PDGFRB/FRAS1/COL9A3/CDH1/FLT4/TGFB1/ITGB5/PDGFRA	4.16665030921461
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/863	85/9376	2.30070206529889	RRM2/TK1/DUT/TYMS/IMPDH2/DTYMK/GMPS/AK2/CANT1/NME1/HDDC2/NT5C3B/AK5/NT5C/NME2/NME1-NME2/ENTPD1/AK1	3.83535688654535
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/863	59/9376	2.57799948936505	RRM2/TK1/DUT/TYMS/DTYMK/UMPS/CANT1/NME1/HDDC2/NT5C3B/NT5C/NME2/NME1-NME2/ENTPD1	3.87119043263911
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/863	89/9376	2.19729972528546	COL1A1/COL6A2/COL1A2/COL4A2/COL4A1/COL6A1/LAMA4/HMMR/COL6A3/ITGA5/SDC4/SDC1/LAMA1/LAMB1/ITGA1/FRAS1/COL9A3/ITGB5	3.61334876934297
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/863	36/9376	3.01789622762972	RNASEH2A/RPA3/POLD2/SSBP1/RFC1/PCNA/RNASEH2C/FEN1/MCM7/RFC3	3.86212530409634
Genetic Information Processing	Transcription	hsa03040	Spliceosome	36/863	243/9376	1.60954465473585	HNRNPA1/HNRNPA3/RBM8A/SNRPF/RBMX/SRSF3/SNRPA/LSM5/SRSF2/SNRPD1/SRSF7/HNRNPU/SNRPD2/SNRPE/SRSF5/LSM4/TRA2A/HNRNPM/SRSF6/LSM7/SNRPB/SRSF9/FUS/THOC2/ALYREF/RBM25/SF3B5/HNRNPC/PPIH/PRPF38B/PRPF38A/MAGOHB/HNRNPA1L2/SNRNP70/TCERG1/SF3B1	3.06514944920798
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/863	154/9376	1.76370558757581	GGH/ALAS2/RDH11/AK2/UMPS/NME1/PDXK/KYNU/VKORC1/DHFR/HMBS/AK5/UROS/MTHFD2/GCH1/UGDH/MTHFD1L/NME2/NME1-NME2/RFK/GGCX/SHMT1/RDH13/CPOX/AK1	3.04245027470587
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/863	204/9376	1.65096675982096	RPS6/CAV1/COL1A1/MMP2/ACTG1/PPP1CB/DCN/LUM/COL1A2/IQGAP1/CD63/BRAF/ITGA5/PPP1CC/FGFR1/GRB2/SDC4/EIF4B/IGF1/PPP1R12A/MAP2K2/SDC1/PPP1CA/MAPK13/PRKCA/CAV2/ITPR2/GPC1/ROCK1/TGFB1/ITGB5	2.99289577304888
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/863	138/9376	1.81073773657783	CCNE1/CCNB1/PTTG1/CALM3/PPP1CB/CCNB2/CDC20/CDK1/MAD2L1/AURKA/YWHAQ/PPP1CC/SMC1A/ADCY5/IGF1/PPP1CA/MAPK13/PLK1/PPP2R1A/PPP2R1B/ITPR2/BUB1/ANAPC5	3.05478515718846
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	31/863	205/9376	1.64291326343159	GAPDH/SLC2A1/COL1A1/MMP2/NDUFA4/COL3A1/UQCRH/PPP1CB/COL1A2/PPIF/INSR/PPP1CC/NDUFB11/COX5B/NDUFV3/PDK3/REN/PPP1CA/SDHA/COX8C/MAPK13/NDUFS2/NDUFC1/PRKCA/GYS1/CYC1/UQCRFS1/COX7A1/NDUFA3/TGFB1/GFPT1	2.96326634507507
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	20/863	116/9376	1.87317696887362	GAPDH/PKM/ENO1/PHGDH/ACAT2/PCCA/ADH5/TPI1/ACAT1/PGLS/GPI/SDHA/PFKP/PRPS2/GPT2/ESD/SHMT1/HK1/SUCLG2/ALDOC	3.01283600507791
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/863	78/9376	2.08931277297442	ENO1/LSM5/PABPC1/HSPD1/LSM4/PABPC4/DHX36/LSM7/EXOSC8/EXOSC3/PNPT1/PFKP/EXOSC5/DCPS/XRN2	3.07577700573694
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	38/863	268/9376	1.5404783729095	HSPA5/TUBB/TUBA1B/TUBA1C/NDUFA4/CALM3/UQCRH/PPIF/TUBB6/XBP1/RPS27A/KIF5B/NDUFB11/COX5B/ADCY5/SLC39A4/SLC39A7/NDUFV3/PSMD11/SDHA/COX8C/MAOA/NDUFS2/PSMA4/NDUFC1/MFN1/UBA1/SLC39A10/ERN1/CYC1/UQCRFS1/TXN2/ITPR2/EIF2S1/COX7A1/NDUFA3/PSMC4/PSMD3	2.85814281597932
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/863	37/9376	2.64269831824872	PGM3/NAGK/NANS/GNPNAT1/GPI/UGDH/PGM1/HK1/GFPT1	3.1875588102158
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/863	170/9376	1.66161815827142	TUBA1B/TUBA1C/CLDN10/ACTG1/CLDN7/CLDN6/RAB8B/JUN/JAM3/ACTN1/RAB13/ACTR3/ACTR2/MYL6B/PCNA/CDK4/PPP2R1A/PPP2R1B/PARD3/CLDN1/MYH9/MYL9/VASP/CGNL1/ARPC1A/ROCK1	2.77169929138802
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/863	39/9376	2.5071753275693	TYMS/AHCY/ALDH7A1/DHFR/CBS/MTHFD2/MTHFD1L/SHMT1/AHCYL1	3.0029086406226
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/863	224/9376	1.55206091706671	HLA-G/CALR/SLC2A1/CCNE1/HLA-C/PTTG1/NFYB/CANX/RAN/TBPL1/RANBP1/CCNB2/CDC20/HLA-E/JUN/MAD2L1/EGR1/CCNA2/IL1R1/FOS/ADCY5/MAP2K2/FDPS/CCND2/BUB3/CDK4/XPO1/XIAP/IL2RB/TGFB1/JAK1/ANAPC5	2.66258036694403
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/863	27/9376	2.81670314578773	HSD17B12/SCD/ELOVL1/ELOVL5/ELOVL6/FADS2/FADS1	3.00976778736826
NA	NA	hsa03272	Virion - Hepatitis viruses	10/863	48/9376	2.26342217072229	CLDN10/CLDN7/CD81/CLDN6/LDLR/CD63/EPCAM/CHMP4A/DPP4/CLDN1	2.79398817059192
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	17/863	103/9376	1.7931577585528	PPP1CB/RBM8A/MSI2/PABPC1/PABPC4/PPP1CC/FIP1L1/PNN/FUS/ALYREF/PPP1CA/UPF3B/PPP2R1A/PPP2R1B/PAPOLA/MAGOHB/CPSF6	2.5770199379058
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/863	50/9376	2.17288528389339	HBA2/HBA1/GYPC/GYPA/GYPB/CD81/HBB/LRP1/SDC1/TGFB1	2.6475401397191
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/863	23/9376	2.83419819638269	RPA3/POLD2/SSBP1/RFC1/PCNA/RFC3	2.80404146981161
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/863	200/9376	1.52101969872538	GAPDH/TUBB/TUBA1B/TUBA1C/CLDN10/ACTG1/CLDN7/TMBIM6/TUBB6/CLDN6/TMED10/JUN/MYO10/IL1R1/MYO1B/FOS/RPS3/NCL/ACTR3/ACTR2/SEC24D/FYN/MAPK13/CLDN1/MYH9/ARPC1A/ROCK1/BAIAP2L1	2.37133088740011
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/863	51/9376	2.13027969009156	KDELR1/PDIA4/ACTG1/KDELR2/SEC61G/SEC61B/SEC61A1/ATP6V0A1/PRKCA/ATP6V1A	2.57689255656521
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/863	157/9376	1.59160387036777	LEP/NDUFA4/UQCRH/XBP1/JUN/INSR/FOS/NDUFB11/COX5B/NDUFV3/SDHA/COX8C/MAPK13/NDUFS2/ITCH/NDUFC1/ERN1/CYC1/UQCRFS1/EIF2S1/COX7A1/NDUFA3/TGFB1	2.38006405058262
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/863	44/9376	2.22226904034552	HMGB1/APEX1/POLD2/RFC1/PCNA/SMUG1/FEN1/NTHL1/RFC3	2.58735192234121
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/863	67/9376	1.945867418412	LDHA/GAPDH/PKM/ENO1/ADH5/ALDH7A1/TPI1/GPI/PFKP/PGM1/HK1/ALDOC	2.47380732685014
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/863	75/9376	1.88316724604094	GAPDH/ARG2/PKM/ENO1/PHGDH/TPI1/CBS/PFKP/PRPS2/GPT2/ASL/SHMT1/ALDOC	2.44488526383149
Cellular Processes	Cell motility	hsa04814	Motor proteins	27/863	194/9376	1.51205934703922	TUBB/TUBA1B/TUBA1C/TPM1/TPM2/DYNLL1/ACTG1/TUBB6/MYL4/MYO10/ACTA2/TNNI2/CENPE/MYO1B/KIF5B/KIF21A/KIF2C/MYL6B/KIF11/KIF4A/KIF20B/KIF22/MYH9/MYL9/KIFC1/DYNLT3/KIF23	2.29457489787693
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/863	142/9376	1.60671094935779	HSP90B1/CAV1/MMP2/CALM3/ACTG1/JUN/MGST1/IL1R1/FOS/HSP90AB1/GSTP1/SDC4/RAC3/SDC1/MAPK13/BMP4/MGST2/CAV2/TXN2/GPC1/GSTA4	2.31942743158842
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/863	38/9376	2.28724766725621	PGM3/NAGK/GNPNAT1/GPI/UGDH/PGM1/HK1/GFPT1	2.53149279900575
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/863	134/9376	1.62155618201	CALM3/PLA2G2A/PPP1CB/CALD1/RAMP1/ACTA2/BRAF/PPP1CC/ADCY5/RAMP2/PPP1R12A/MAP2K2/MYL6B/PPP1CA/PRKCA/PLA2G10/ITPR2/MYH9/MYL9/ROCK1	2.307275883892
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/863	93/9376	1.75232684184951	ACTG1/IQGAP1/ACTN1/INSR/ACP1/HEG1/FGFR1/TCF7L2/RAC3/FYN/VCL/PARD3/MYL9/CDH1/ROCK1	2.3214192180348
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	45/863	362/9376	1.35055024551385	RPS6/HSP90B1/CCNE1/COL1A1/COL6A2/COL1A2/COL4A2/COL4A1/COL6A1/LAMA4/YWHAQ/COL6A3/INSR/ITGA5/HSP90AB1/FGFR1/GRB2/EIF4B/EIF4EBP1/IGF1/FGF7/MAP2K2/GNB1/GNB2/LAMA1/CCND2/LAMB1/PRKCA/GYS1/CDK4/FGFR3/PPP2R1A/PPP2R1B/ITGA1/PDGFRB/COL9A3/BRCA1/FLT4/EFNA4/PKN2/IL2RB/ITGB5/JAK1/PDGFRA/SGK2	2.16568607137481
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	19/863	128/9376	1.61268829663963	RRM2/IMPDH2/GMPS/PAICS/AK2/CANT1/NME1/ADCY5/HDDC2/PDE4D/PRPS2/AK5/NT5C/NUDT5/NME2/PGM1/NME1-NME2/ENTPD1/AK1	2.22213468523973
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/863	71/9376	1.83624108498033	LDHA/SLC2A1/PKM/SLC16A3/FGFR1/MAP2K2/PFKP/SLC1A5/FGFR3/PDGFRB/HK1/PDGFRA	2.25191609973665
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/863	157/9376	1.52240370209091	HLA-G/CCNE1/HLA-C/CCNB1/CALM3/PPP1CB/CCNB2/CDK1/HLA-E/CCNA2/PPP1CC/EIF4EBP1/MAP2K2/PPP1CA/CCND2/MAPK13/MYBL2/CDK4/FOXO1/ITPR2/GADD45A/TGFB1	2.10166689826576
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/863	106/9376	1.63991342180634	HSP90B1/CCNE1/SLC19A1/ETV5/BRAF/HSP90AB1/FGFR1/GSTP1/TCF7L2/GRB2/IGF1/ZEB1/MAP2K2/FOXO1/PDGFRB/PDGFRA	2.1095217343028
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/863	232/9376	1.40488272665521	ACTG1/PPP1CB/IQGAP1/ACTN1/BRAF/ITGA5/PPP1CC/FGFR1/DIAPH3/RAC3/ACTR3/PPP1R12A/ACTR2/FGF7/MAP2K2/PPP1CA/VCL/ENAH/FGFR3/DIAPH1/ITGA1/PDGFRB/CXCL12/MYH9/MYL9/ARPC1A/ROCK1/ITGB5/PIP5K1C/PDGFRA	1.9881761152951
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/863	82/9376	1.72240906650086	RRM2/TK1/DUT/MGST1/IMPDH2/GMPS/UMPS/NME1/GSTP1/MGST2/NME2/NME1-NME2/GSTA4	2.09188834079608
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/863	50/9376	1.95559675550406	ARG2/SRM/ODC1/ALDH7A1/P4HA1/P4HA2/GAMT/CKB/MAOA	2.15705730332301
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/863	75/9376	1.73830822711472	CCNE1/CCNB1/RRM2/CCNB2/CDK1/IGF1/EI24/GTSE1/CCND2/CDK4/GADD45A/SHISA5	2.04386984767622
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/863	75/9376	1.73830822711472	CGA/HSPA5/GPX3/HSP90B1/CANX/PDIA4/GPX8/FXYD2/ADCY5/ATP1A1/PRKCA/ITPR2	2.04386984767622
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/863	59/9376	1.84142820668932	GPX3/RRM2/SRM/ODC1/MGST1/GPX8/GGCT/GSTP1/MGST2/GSTA4	2.06421411758444
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/863	15/9376	2.89718037852453	AK2/ACP1/AK5/AK1	2.34122337017033
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/863	103/9376	1.58219802225247	ARG2/COL1A1/COL3A1/COL1A2/COL4A2/COL4A1/SERPINB9/LAMA4/ACTN1/IL1R1/LAMA1/LAMB1/VCL/PRKCA/TGFB1	1.89159835477303
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/863	61/9376	1.78105351138803	MT1E/MT1G/MT1H/FXYD2/MT1F/SLC39A4/ATP1A1/MT1X/SLC6A19/ATP2B4	1.94851609039662
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/863	130/9376	1.50430519654158	COL1A1/MMP2/COL3A1/COL1A2/COL4A2/COL4A1/RLN2/JUN/ACTA2/FOS/ADCY5/GRB2/MAP2K2/GNB1/GNB2/MAPK13/PRKCA/TGFB1	1.8434777247422
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/863	30/9376	2.17288528389339	SLC19A1/GGH/TYMS/ABCG2/DHFR/SHMT1	2.04858031693298
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/863	70/9376	1.70726700877338	HLA-G/HLA-C/CAV1/ACTG1/CD55/HLA-E/RAC3/SSPN/FYN/LAMA1/SGCB	1.89103956626539
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/863	87/9376	1.62342003969047	BIRC5/JUN/BRAF/FOS/RALB/TCF7L2/GRB2/RAC3/MAP2K2/RALA/GADD45A/TGFB1/AXIN1	1.85996864356561
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/863	54/9376	1.81073773657783	LDHA/SRM/PHGDH/MPST/AHCY/CISD1/CBS/TST/AHCYL1	1.90227122319709
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/863	10/9376	3.25932792584009	MPST/TST/SELENBP1	2.27589338212093
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/863	31/9376	2.10279221021941	PGLS/GPI/PFKP/PRPS2/PGM1/ALDOC	1.95809880848398
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/863	89/9376	1.58693869048394	TUBB/TUBA1B/TUBA1C/CDK1/TUBB6/ADCY5/GRB2/GJA1/MAP2K2/PRKCA/ITPR2/PDGFRB/PDGFRA	1.77133106285002
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/863	116/9376	1.49854157509889	CLDN10/MMP2/ACTG1/CLDN7/CLDN6/JAM3/ACTN1/THY1/VCL/MAPK13/PRKCA/CLDN1/CXCL12/MYL9/VASP/ROCK1	1.72018280489439
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/863	32/9376	2.03707995365006	B4GALT1/PFKP/GLA/PGM1/HK1/GLB1	1.870985980246
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/863	99/9376	1.53638353406604	JUN/LYPLA1/FOS/SLC44A1/CHPT1/GRB2/EIF4EBP1/RAC3/MAP2K2/PRKCA/PDGFRB/SLC44A2/PIP5K1C/PDGFRA	1.7082010156383
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/863	57/9376	1.71543575044215	HSD17B12/ACAT2/SCD/ACAT1/ELOVL1/ELOVL5/ELOVL6/FADS2/FADS1	1.7249365691488
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/863	137/9376	1.42744288722924	TUBA1B/TUBA1C/BIRC5/ACTG1/JUN/FOS/LMNB1/LMNB2/MAP2K2/GZMB/CTSW/CASP6/ERN1/CTSV/ITPR2/XIAP/EIF2S1/GADD45A	1.6046326107864
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/863	41/9376	1.85490207161631	PHGDH/ALAS2/ALDH7A1/CBS/GAMT/MAOA/SHMT1	1.74662976172255
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/863	101/9376	1.5059600977479	COL1A1/MMP2/COL3A1/COL1A2/COL4A2/COL4A1/JUN/EGR1/MAPK13/PRKCA/CDK4/DIAPH1/FOXO1/TGFB1	1.62768257764268
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/863	110/9376	1.48151269356368	LDHA/RPS6/GAPDH/SLC2A1/ENO1/TIMP1/EGLN3/INSR/EIF4EBP1/IGF1/MAP2K2/PFKP/PRKCA/HK1/ALDOC	1.61736356151622
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/863	110/9376	1.48151269356368	CCNB1/CCNB2/CDK1/MAD2L1/AURKA/CCNA2/BRAF/HSP90AB1/ADCY5/IGF1/MAPK13/PLK1/KIF22/BUB1/ANAPC5	1.61736356151622
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	42/863	368/9376	1.23996171091743	HSPA5/GPX3/TUBB/TUBA1B/TUBA1C/HNRNPA1/SLC1A2/HNRNPA3/NDUFA4/UQCRH/ACTG1/CHCHD10/TUBB6/SRSF3/XBP1/SRSF7/GPX8/KIF5B/NDUFB11/COX5B/NDUFV3/FUS/HNRNPA2B1/ALYREF/PSMD11/SDHA/COX8C/MAPK13/NDUFS2/PSMA4/NDUFC1/NUP37/ERN1/CYC1/UQCRFS1/EIF2S1/HNRNPA1L2/SIGMAR1/COX7A1/NDUFA3/PSMC4/PSMD3	1.49520723460668
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/863	157/9376	1.38400336553719	BIRC5/ACTG1/PPP1CB/ID1/YWHAQ/PPP1CC/ID2/TCF7L2/PPP1CA/CCND2/TEAD4/BMP4/PPP2R1A/PPP2R1B/PARD3/CDH1/TGFB1/WWTR1/MOB1A/AXIN1	1.54487259363203
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/863	86/9376	1.51596647713493	ACTG1/DSC2/ITGA5/DSP/TCF7L2/GJA1/SSPN/LAMA1/DSG2/ITGA1/SGCB/ITGB5	1.53042684145285
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/863	333/9376	1.23978439621545	HLA-G/CCNE1/HLA-C/PKM/COL1A1/COL6A2/TBPL1/COL1A2/COL4A2/COL4A1/COL6A1/HLA-E/LAMA4/ISG15/CCNA2/COL6A3/ITGA5/TCF7L2/GRB2/EIF4EBP1/CHD4/MAP2K2/LAMA1/CCND2/LAMB1/ATP6V0A1/CDK4/PPP2R1A/ATP6V1A/PPP2R1B/PARD3/ITGA1/FOXO1/PDGFRB/COL9A3/ITGB5/JAK1/AXIN1	1.41852334993966
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/863	36/9376	1.81073773657783	PYGL/GPI/GYS1/GYG2/PGM1/HK1	1.55170057040098
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/863	13/9376	2.5071753275693	XRCC5/PRKDC/FEN1	1.7313212516144
NA	NA	hsa04517	IgSF CAM signaling	34/863	299/9376	1.23541972662835	TUBB/TUBA1B/TUBA1C/DYNLL1/ACTG1/TUBB6/IQGAP1/JAM3/ACTN1/ITGA5/FGFR1/GRB2/ACTR3/SPTBN1/MTSS1/PTPRS/ACTR2/MAP2K2/MYL6B/FYN/VCL/MAPK13/PRKCA/ERC1/PARD3/FOXO1/CNTNAP2/MYH9/CLMP/MYL9/CDH1/ARPC1A/LYN/ROBO1	1.31721599844509
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/863	80/9376	1.49385863267671	RPS6/BRAF/GRB2/EIF4EBP1/IGF1/MAP2K2/PRKCA/FGFR3/PDGFRB/JAK1/PDGFRA	1.4123726693627
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/863	108/9376	1.40835157289387	RAN/RBM8A/KPNA2/KPNB1/PNN/THOC2/ALYREF/TMEM33/IPO5/UPF3B/NUP37/XPO1/TNPO1/MAGOHB	1.35894793264987
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/863	37/9376	1.76179887883248	NCOA4/BRAF/TCF7L2/MAP2K2/CDH1/GADD45A	1.47822561261509
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/863	21/9376	2.06941455608895	DSEL/CHSY1/CHPF/B4GALT7	1.56200910805326
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/863	73/9376	1.4882775917078	BRAF/FGFR1/IGF1/FGF7/MAP2K2/CDK4/PDGFRB/CDH1/GADD45A/PDGFRA	1.33341836653722
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/863	38/9376	1.71543575044215	HSD11B2/INSR/FXYD2/ATP1A1/IGF1/PRKCA	1.40697124295904
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/863	14/9376	2.32809137560007	B4GALT1/B3GNT7/B3GNT2	1.58327872215255
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/863	110/9376	1.38274518065943	GREM2/DCN/ID1/LRRC32/ID4/ID2/ZFYVE16/BMP4/PPP2R1A/PPP2R1B/TFDP1/LTBP1/ROCK1/TGFB1	1.28561119326472
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/863	235/9376	1.24825324819408	RPS6/NDUFA4/UQCRH/ACTG1/COX20/KDM1A/NDUFB11/COX5B/ADCY5/FGFR1/GRB2/NDUFV3/SLC25A29/NDUFAF2/SDHA/COX8C/MAPK13/NDUFS2/NDUFC1/SMARCC1/CYC1/UQCRFS1/COA1/SMARCA2/COX7A1/NDUFA3/ACTL6A	1.2271050280381
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/863	47/9376	1.6181060624738	LDHA/PKM/ACAT2/ADH5/ALDH7A1/ACAT1/GLO1	1.35252127435813
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	31/863	275/9376	1.22471716001264	HSPA5/TUBB/TUBA1B/TUBA1C/CAV1/NDUFA4/UQCRH/PPIF/TUBB6/EGR1/KIF5B/NDUFB11/COX5B/NDUFV3/PSMD11/SDHA/COX8C/FYN/MAPK13/NDUFS2/PSMA4/NDUFC1/CAV2/CYC1/UQCRFS1/ITPR2/EIF2S1/COX7A1/NDUFA3/PSMC4/PSMD3	1.20422529852826
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/863	93/9376	1.40186147347961	CGA/MMP2/CALM3/JUN/EGR1/ADCY5/GRB2/MAP2K2/MAPK13/PRKCA/MMP14/ITPR2	1.24000486973181
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/863	48/9376	1.5843955195056	ACAT2/HMGCS1/PCCA/ALDH7A1/ACAT1/HSD17B10/HMGCS2	1.2923583314294
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/863	122/9376	1.33579013354102	LEP/EEF2/HMGCR/CCNA2/SCD/INSR/CAB39L/EIF4EBP1/IGF1/PFKP/GYS1/PPP2R1A/PPP2R1B/EEF2K/FOXO1	1.1885920423269
NA	NA	hsa04981	Folate transport and metabolism	5/863	31/9376	1.75232684184951	SLC19A1/TYMS/ABCG2/DHFR/SHMT1	1.33581855127808
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/863	180/9376	1.26751641560448	HLA-G/CALR/HLA-C/PDIA3/PPP1CB/SRSF3/HLA-E/SRSF2/SRSF7/SRSF5/ITGA5/SRSF6/PPP1CC/SRPK1/EIF4EBP1/SRSF9/ALYREF/PPP1CA/EIF2S1/POU2F1/JAK1	1.15381698394411
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/863	76/9376	1.42952979203513	CALM3/BRAF/GRB2/IGF1/MAP2K2/PRKCA/CDK4/PDGFRB/GADD45A/PDGFRA	1.19703909048217
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/863	133/9376	1.30699866700355	CCNB1/CCNB2/BNIP3/INSR/BRAF/GRB2/IGF1/MAP2K2/CCND2/MAPK13/SETD7/PLK1/FOXO1/GADD45A/TGFB1/SGK2	1.13528670786821
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/863	77/9376	1.41096447006065	RALBP1/BRAF/RALB/RAC3/RAD51/CDK4/RALA/GADD45A/TGFB1/JAK1	1.15287237994383
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/863	212/9376	1.22993506635475	CALM3/ACTG1/ID1/INSR/BRAF/RALB/ADCY5/FGFR1/RAC3/IGF1/FGF7/MAP2K2/MAPK13/PRKCA/ENAH/FGFR3/PARD3/PDGFRB/VASP/RALA/CDH1/FLT4/EFNA4/PDGFRA	1.07815280759062
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/863	41/9376	1.58991606138541	MMP2/BRAF/MAP2K2/CDK4/FGFR3/CDH1	1.20524324825398
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/863	87/9376	1.37366311050732	TPM1/TPM2/UQCRH/MYL4/FXYD2/COX5B/ATP1A1/COX8C/CYC1/UQCRFS1/COX7A1	1.11482086643522
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/863	24/9376	1.81073773657783	EXT1/HS6ST1/HS6ST2/B4GALT7	1.26614510199734
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/863	155/9376	1.26167532613165	HLA-G/CALR/TUBB/TUBA1B/TUBA1C/HLA-C/CANX/ACTG1/SEC61G/TUBB6/SEC61B/C1R/HLA-E/ITGA5/SEC61A1/ATP6V0A1/ATP6V1A/ITGB5	1.04589799763922
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/863	69/9376	1.41709909819134	CALM3/PPP1CB/JUN/FOS/PPP1CC/ADCY5/PPP1CA/MAOA/PRKCA	1.107155593833
Organismal Systems	Immune system	hsa04611	Platelet activation	15/863	126/9376	1.29338409755559	COL1A1/COL3A1/ACTG1/PPP1CB/COL1A2/PPP1CC/ADCY5/PPP1R12A/PPP1CA/FYN/MAPK13/ITPR2/VASP/ROCK1/LYN	1.05560319350301
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/863	60/9376	1.44859018926226	BRAF/IGF1/MAP2K2/PRKCA/PPP2R1A/PPP2R1B/ITPR2/LYN	1.10984000668568
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/863	42/9376	1.55206091706671	ACAT2/KYNU/ALDH7A1/ACAT1/DHTKD1/MAOA	1.14163550994753
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/863	52/9376	1.46251894108209	CGA/CYP2J2/LDLR/INSR/ADCY5/HSD17B7/IGF1	1.06482878188602
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	16/863	138/9376	1.25964364283675	NDUFA4/UQCRH/PPA1/NDUFB11/COX5B/NDUFV3/SDHA/COX8C/NDUFS2/ATP6V0A1/NDUFC1/CYC1/ATP6V1A/UQCRFS1/COX7A1/NDUFA3	0.978313344145054
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/863	138/9376	1.25964364283675	RPS6/CALM3/CBLB/PPP1CB/PYGL/INSR/BRAF/PPP1CC/GRB2/EIF4EBP1/MAP2K2/PPP1CA/SH2B2/GYS1/FOXO1/HK1	0.978313344145054
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/863	160/9376	1.22224797219003	HLA-G/HLA-C/CLDN10/CLDN7/CLDN6/HLA-E/VCAN/JAM3/SDC4/PTPRS/SDC1/NRXN3/CNTNAP2/CLDN1/CD276/SELL/CDH1/CD274	0.902768266751987
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/863	82/9376	1.32493005115451	HLA-G/HSPA5/CALR/HLA-C/PDIA3/NFYB/CANX/HLA-E/HSPA2/HSP90AB1	0.940903730453916
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/863	63/9376	1.3796097040593	ACAT2/EZH2/ALDH7A1/ACAT1/PLOD1/DHTKD1/SETD7/HYKK	0.962526063994864
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	16/863	142/9376	1.22416072332022	UBE2S/UBE2C/CBLB/CDC20/RPS27A/SAE1/FBXW7/ITCH/UBE2K/UBA1/UBA2/UBE2E3/CDC34/XIAP/BRCA1/ANAPC5	0.856955905120834
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/863	27/9376	1.60954465473585	ACAT2/HMGCS1/ACAT1/HMGCS2	1.00984460286767
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/863	93/9376	1.28503968402298	CCNE1/CKS1B/COL4A2/COL4A1/LAMA4/LAMA1/LAMB1/CDK4/TRAF4/XIAP/GADD45A	0.87953342029748
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/863	133/9376	1.22531125031582	CALM3/PPP1CB/FOS/KIF5B/PPP1CC/ADCY5/GNB1/PPP1CA/GNB2/MAPK13/MAOA/PRKCA/PPP2R1A/PPP2R1B/ITPR2	0.833205140964891
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	40/863	388/9376	1.12004396076979	GAPDH/TUBB/TUBA1B/TUBA1C/NDUFA4/CALM3/UQCRH/PPIF/TUBB6/BACE2/XBP1/DKK1/INSR/BRAF/KIF5B/NDUFB11/COX5B/SLC39A4/SLC39A7/NDUFV3/LRP1/MAP2K2/PSMD11/SDHA/COX8C/HSD17B10/NDUFS2/PSMA4/NDUFC1/SLC39A10/ERN1/CYC1/UQCRFS1/ITPR2/EIF2S1/COX7A1/NDUFA3/PSMC4/PSMD3/AXIN1	0.768907977059146
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/863	46/9376	1.41709909819134	ALAS2/CP/HMBS/UROS/BLVRB/CPOX	0.90287382814142
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/863	154/9376	1.19931979955155	CALM3/EEF2/ACTG1/PPP1CB/JUN/FOS/PPP1CC/ADCY5/PPP1R12A/MAP2K2/MYL6B/PPP1CA/PRKCA/EEF2K/ITPR2/MYL9/ROCK1	0.794050205688372
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/863	37/9376	1.4681657323604	HBA2/HBA1/LAMA4/HBB/PRKCA	0.908447880081521
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/863	28/9376	1.55206091706671	HSD17B12/ELOVL1/ELOVL5/ELOVL6	0.93144321975294
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/863	28/9376	1.55206091706671	B3GNT5/B4GALT1/ST3GAL4/B3GNT2	0.93144321975294
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/863	105/9376	1.24164873365337	TPM1/TPM2/ACTG1/ITGA5/ADCY5/IGF1/SSPN/LAMA1/ITGA1/SGCB/TGFB1/ITGB5	0.792803578817803
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/863	115/9376	1.22815255176583	NACA/EGR1/BRAF/FOS/ADCY5/FGFR1/PDE4D/GCM1/MMP15/PRKCA/PTH1R/MMP14/ITPR2	0.783781535267366
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/863	227/9376	1.14866182408461	HLA-G/CALR/HLA-C/PDIA3/CALM3/HLA-E/IL1R1/ADCY5/GRB2/EIF4EBP1/IL10RB/RAC3/MAP2K2/GNB1/GNB2/MAPK13/PRKCA/CDK4/ITPR2/CXCL12/CCL3L1/ROCK1/JAK1/PDGFRA	0.721897090513784
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	24/863	227/9376	1.14866182408461	NDUFA4/UQCRH/PPIF/JUN/MGST1/BRAF/FOS/ACP1/NDUFB11/COX5B/GRB2/NDUFV3/MAP2K2/SDHA/COX8C/MAPK13/NDUFS2/NDUFC1/MGST2/CYC1/UQCRFS1/COX7A1/NDUFA3/GSTA4	0.721897090513784
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/863	67/9376	1.297244945608	CALM3/PPP1CB/BRAF/PPP1CC/MAP2K2/PPP1CA/PRKCA/ITPR2	0.77740993082177
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/863	157/9376	1.17640286070662	CALR/SLC2A1/ARG2/BSG/ODC1/SLC16A1/DUSP8/LRP1/MFGE8/MAP2K2/PBX1/MAPK13/UQCRFS1/MERTK/TGFB1/ITGB5/ATP11B	0.709681136681452
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/863	78/9376	1.25358766378465	CAV1/ACTG1/ITGA5/ACTR3/ACTR2/VCL/CAV2/CDH1/ARPC1A	0.716028604968628
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/863	59/9376	1.28899974468252	BRAF/TCF7L2/GRB2/MAP2K2/CDH1/GADD45A/AXIN1	0.708981881293446
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/863	69/9376	1.25964364283675	GRB2/RAC3/MAP2K2/FYN/MAPK13/PRKCA/LYN/GAB2	0.689202908412931
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/863	99/9376	1.20715849105189	CALM3/PPP1CB/CYP2J2/IL1R1/PPP1CC/ADCY5/IGF1/PPP1CA/MAPK13/PRKCA/ITPR2	0.659730066899038
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/863	99/9376	1.20715849105189	TPM1/TPM2/ACTG1/ITGA5/IGF1/SSPN/LAMA1/ITGA1/SGCB/TGFB1/ITGB5	0.659730066899038
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/863	12/9376	1.81073773657783	VKORC1/GGCX	0.894725938717882
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/863	31/9376	1.40186147347961	ACAT2/PCCA/ACAT1/SHMT1	0.713538294072173
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/863	41/9376	1.32493005115451	RPA3/POLD2/SSBP1/RAD51/BRCA1	0.663856734785418
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	25/863	248/9376	1.09520427615595	HSP90B1/GAPDH/TUBB/TUBA1B/TUBA1C/DYNLL1/ACTG1/TUBB6/JUN/FOS/KIF5B/RIPK2/HSP90AB1/RPS3/PIK3C2A/TCF7L2/ACTR3/ACTR2/MAP2K2/MAPK13/TXN2/MYL9/RALA/DYNLT3/ARPC1A	0.483775866503886
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/863	23/9376	1.41709909819134	ARG2/GPT2/ASL	0.637642742565175
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/863	23/9376	1.41709909819134	CA2/FXYD2/ATP1A1	0.637642742565175
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/863	73/9376	1.19062207336624	PPIA/RAN/CHMP4A/MAP1B/XPO1/PIN1/CPSF6/FURIN	0.520562438273967
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/863	63/9376	1.20715849105189	POLR2H/RPA3/POLD2/RFC1/CDK7/PCNA/RFC3	0.525264356740838
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/863	156/9376	1.11430014558636	CLDN10/CLDN7/CD81/CLDN6/LDLR/YWHAQ/BRAF/EIF3E/GRB2/MAP2K2/CDK4/PPP2R1A/PPP2R1B/CLDN1/EIF2S1/JAK1	0.458345890214906
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/863	44/9376	1.23459391130307	HLA-G/HLA-C/HLA-E/HSPD1/GZMB	0.49659852891958
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/863	75/9376	1.15887215140981	BIRC5/TOP2A/MGST1/GSTP1/MGST2/XIAP/BRCA1/GSTA4	0.43980818305511
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/863	117/9376	1.11430014558636	ACTG1/MORF4L2/RUVBL2/ACTR6/BPTF/CHD4/RUVBL1/CDK2AP2/CHD3/SMARCC1/SMARCA2/ACTL6A	0.396102325148417
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/863	170/9376	1.0864426419467	ACTG1/MGST1/BRAF/GSTP1/TCF7L2/GRB2/MAP2K2/PRKCA/CDK4/SMARCC1/MGST2/SMARCA2/GADD45A/TGFB1/GSTA4/ACTL6A/AXIN1	0.362131852691806
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	30/863	308/9376	1.05822335254548	GPX3/TUBB/TUBA1B/TUBA1C/SLC1A2/NDUFA4/UQCRH/TBPL1/PPIF/TUBB6/POLR2H/GPX8/KIF5B/NDUFB11/COX5B/TFAM/NDUFV3/PSMD11/SDHA/COX8C/NDUFS2/PSMA4/NDUFC1/ERN1/CYC1/UQCRFS1/COX7A1/NDUFA3/PSMC4/PSMD3	0.330800784423024
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/863	76/9376	1.1436238336281	CALM3/ACTG1/CA2/GAST/ADCY5/ATP1A1/PRKCA/ITPR2	0.400259414750179
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/863	35/9376	1.24164873365337	TPI1/PFKP/HK1/ALDOC	0.456007073150116
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/863	15/9376	1.44859018926226	SLC33A1/GLB1	0.553584596709113
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/863	98/9376	1.10861494076194	MYO10/ACTR3/ACTR2/PRKCA/MARCKSL1/VASP/ARPC1A/LYN/GAB2/PIP5K1C	0.344132066799719
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/863	36/9376	1.20715849105189	GCNT1/C1GALT1/GALNT2/GALNT1	0.396488203553309
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/863	205/9376	1.05994404092361	HLA-G/CCNE1/HLA-C/PKM/TBPL1/RANBP1/REL/CDC20/CDK1/HLA-E/JUN/CCNA2/YWHAQ/ACTN1/GRB2/CHD4/CCND2/CDK4/LYN/JAK1	0.276289461052049
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/863	99/9376	1.09741681004717	MMP2/JUN/BRAF/FOS/ADCY5/GRB2/IGF1/MAP2K2/MAPK13/CDK4	0.310239750652619
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/863	26/9376	1.25358766378465	PLA2G2A/PLA2G10/FADS2	0.412248145475393
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/863	238/9376	1.04992356154513	CALM3/RALBP1/PLA2G2A/REL/INSR/RALB/FGFR1/GRB2/RAC3/IGF1/FGF7/MAP2K2/GNB1/GNB2/PRKCA/FGFR3/PLA2G10/PDGFRB/RALA/FLT4/EFNA4/GAB2/PDGFRA	0.2483808913987
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/863	68/9376	1.11839683729807	CCNA2/BRAF/TCF7L2/GRB2/EIF4EBP1/MAP2K2/RUNX1T1	0.31197233951526
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/863	250/9376	1.04298493626883	HLA-G/HLA-C/CAV1/CBLB/HLA-E/LDLR/KIF5B/CHMP4A/ZFYVE16/MVB12A/EHD3/ACTR3/ACTR2/VPS28/SNF8/ARF4/ITCH/CAV2/FGFR3/PARD3/ARPC1A/IL2RB/PIP5K1C/PDGFRA	0.219328858658116
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/863	37/9376	1.17453258588832	RIMKLB/GPT2/ASL/GFPT1	0.338670147547951
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/863	154/9376	1.05822335254548	TPM1/TPM2/CALM3/PPP1CB/MYL4/PPP1CC/FXYD2/ADCY5/ATP1A1/PPP1CA/MAPK13/ATP2B4/PRKCA/PPP2R1A/PPP2R1B	0.231950188433999
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/863	122/9376	1.06863210683282	SLC2A1/DIO3/ACTG1/DIO2/FXYD2/MED30/ATP1A1/MAP2K2/PFKP/BMP4/PRKCA/FOXO1	0.242936191035079
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/863	144/9376	1.0562636796704	ID1/ID4/ID2/FGFR1/GRB2/IGF1/MAP2K2/MAPK13/BMP4/ZFHX3/FGFR3/PCGF2/JAK1/AXIN1	0.21662630864757
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/863	166/9376	1.047173630792	CALM3/PPP1CB/PPIF/INSR/PPP1CC/FXYD2/ADCY5/ATP1A1/PPP1R12A/MAP2K2/PPP1CA/ATP2B4/ITPR2/MYL9/VASP/ROCK1	0.19524200187823
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/863	70/9376	1.0864426419467	SLC2A1/JUN/EGLN3/BRAF/GRB2/MAP2K2/TGFB1	0.231124107453023
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/863	17/9376	1.27816781405494	PCDH1/MYH9	0.365482287212556
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/863	28/9376	1.16404568780003	GGH/DHFR/GCH1	0.276779679392853
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/863	28/9376	1.16404568780003	CA2/ATP6V0A1/ATP6V1A	0.276779679392853
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/863	71/9376	1.07114063290519	CGA/FOS/GRB2/ELF5/MAP2K2/CCND2/MAPK13	0.191574821498313
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/863	201/9376	1.02698558193966	REL/LMO2/ETV5/CCNA2/ID2/FUS/IGF1/NFKBIZ/MYCN/ZEB1/PBX1/CCND2/GZMB/FOXO1/RUNX1T1/ETV4/MLF1/IL2RB/GADD45A	0.123133578077062
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/863	39/9376	1.11430014558636	HLA-G/HLA-C/HLA-E/GZMB	0.227732559395887
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/863	148/9376	1.02771601265228	JUN/BRAF/FOS/FGFR1/TCF7L2/GRB2/IGF1/FGF7/MAP2K2/CDK4/BRCA1/FLT4/GADD45A/AXIN1	0.108207542787979
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/863	83/9376	1.047173630792	SUZ12/EZH2/AURKB/RYBP/WDR5/TFDP1/PCGF2/ASXL1	0.13743903609805
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/863	18/9376	1.20715849105189	NEU1/GLB1	0.280089733554791
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/863	29/9376	1.12390618132417	TEAD4/WWTR1/MOB1A	0.212767636638008
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/863	138/9376	1.02346045980486	ACTG1/JUN/ITGA5/FOS/RAC3/ACTR3/ACTR2/MAP2K2/MAPK13/PKN2/ARPC1A/ROCK1/PIP5K1C	0.0883968528407371
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/863	149/9376	1.02081858974857	INSR/RALB/ADCY5/AGPAT5/GRB2/MAP2K2/FYN/PRKCA/AGPAT4/PDGFRB/RALA/GAB2/PIP5K1C/PDGFRA	0.0815574991615979
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/863	51/9376	1.06513984504578	PLA2G2A/CHPT1/PAFAH1B3/LPCAT1/PLA2G10	0.148510482233551
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/863	73/9376	1.04179431419546	BRAF/KIF5B/GRB2/MAP2K2/PRKCA/CDK4/GADD45A	0.114134474142339
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	19/863	205/9376	1.00694683887743	HLA-G/CALR/CCNE1/HLA-C/PDIA3/HLA-E/JUN/ISG15/CCNA2/PSMD11/CCND2/MAPK13/CDK4/ENTPD1/PSMC4/GADD45A/LYN/PSMD3/JAK1	0.0320188352317742
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/863	52/9376	1.04465638648721	LDLR/LRP1/PLTP/LIPG/SORT1	0.102809639569261
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/863	30/9376	1.0864426419467	PLA2G2A/CYP2J2/PLA2G10	0.150982109902391
NA	NA	hsa04382	Cornified envelope formation	20/863	217/9376	1.00132962391401	KRT19/CLDN10/CLDN7/COL4A2/S100A13/COL4A1/CLDN6/KAZN/DSP/KRT10/ELOVL1/S100A1/S100A16/ABHD5/PPP2R1A/DSG2/PADI1/PPP2R1B/CLDN1/FURIN	0.00630934643368561
NA	NA	hsa04519	Cadherin signaling	37/863	404/9376	0.995009350297718	KRT19/ACTG1/PPP1CB/DSC2/YWHAQ/ACTN1/MYO1B/PPP1CC/DSP/FGFR1/TCF7L2/KRT10/LIMA1/RAC3/GJA1/ACTR3/ACTR2/MAP2K2/PPP1CA/VCL/TEAD4/MAPK13/ENAH/PCDH1/DSG2/DSC3/PDGFRB/VASP/CDH1/FLT4/DAAM1/ARPC1A/ROCK1/WWTR1/MOB1A/AXIN1/PDGFRA	-0.0326477199865571
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/863	53/9376	1.02494588862896	FXYD2/ATP1A1/ATP2B4/PRKCA/PTH1R	0.0579840827104576
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/863	42/9376	1.03470727804447	CP/NCOA4/SLC3A2/PCBP2	0.0717729870821586
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/863	76/9376	1.00067085442459	PLIN2/HMGCS1/SCD/FABP7/PLTP/HMGCS2/FADS2	0.00186957688418331
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/863	65/9376	1.00287013102772	CGA/MAP2K2/PRKCA/KCNN4/KISS1R/ITPR2	0.00739281703612387
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/863	20/9376	1.0864426419467	NANS/UGDH	0.123210477983748
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/863	54/9376	1.00596540920991	RPA3/FANCI/UBE2T/RAD51/BRCA1	0.0139969138756232
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/863	54/9376	1.00596540920991	HLA-G/CGA/HLA-C/HLA-E/GZMB	0.0139969138756232
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/863	43/9376	1.01064431808995	ACAT2/ADH5/ALDH7A1/ACAT1	0.022273638077576
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/863	43/9376	1.01064431808995	PLA2G2A/ACAT2/ACAT1/PLA2G10	0.022273638077576
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/863	88/9376	0.987675129042452	TFPI/CFD/CD55/C1R/SERPINB2/PROCR/C1S/CD46	-0.0369838682181583
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/863	77/9376	0.987675129042452	BRAF/GRB2/MAP2K2/CDK4/GADD45A/TGFB1/GAB2	-0.0345747731214617
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/863	122/9376	0.979579431263416	CBLB/JUN/FOS/MAP3K8/GRB2/MAP2K2/FYN/MAPK13/CDK4/PPP2R1A/PPP2R1B	-0.0722824260621945
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/863	32/9376	1.01853997682503	LDHA/PCCA/SUCLG2	0.0334477940602636
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/863	55/9376	0.987675129042452	NEU1/CERS5/DEGS2/GLA/GLB1	-0.0291865116133842
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/863	78/9376	0.975012627388062	CALM3/C1R/JUN/C1S/ITGA5/FOS/MAPK13	-0.070554195287477
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/863	112/9376	0.970038073166694	PPIF/LAMA4/LDLR/IL10RB/LAMA1/LAMB1/MAPK13/XIAP/TGFB1/JAK1	-0.101561521078852
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/863	90/9376	0.965726792841509	SLC2A1/HMGCR/LDLR/CA2/ABCG2/FXYD2/ADCY5/ATP1A1	-0.104018690091957
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	43/863	480/9376	0.973271533410583	HSPA5/GPX3/TUBB/TUBA1B/TUBA1C/NDUFA4/CALM3/UQCRH/PPIF/TUBB6/XBP1/RPS27A/DKK1/BRAF/GPX8/KIF5B/NDUFB11/COX5B/NDUFV3/FUS/MAP2K2/PSMD11/SDHA/COX8C/HSD17B10/MAPK13/NDUFS2/PSMA4/NDUFC1/PRKCA/MFN1/UBA1/ERN1/CYC1/UQCRFS1/ITPR2/EIF2S1/SIGMAR1/COX7A1/NDUFA3/PSMC4/PSMD3/AXIN1	-0.191402230695811
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/863	158/9376	0.962670695395808	RPS6/SLC3A2/INSR/BRAF/CLIP1/CAB39L/RICTOR/GRB2/EIF4B/EIF4EBP1/IGF1/MAP2K2/PRKCA/ATP6V1A	-0.150664110047453
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/863	102/9376	0.958625860541204	PLA2G2A/CA2/FXYD2/ADCY5/ATP1A1/ATP2B4/PRKCA/PLA2G10/ITPR2	-0.133765843801227
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/863	45/9376	0.965726792841509	HLA-G/HLA-C/HLA-E/GZMB	-0.0733747488130322
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/863	91/9376	0.955114410502591	CD81/JUN/FOS/GRB2/IFITM1/RAC3/MAP2K2/LYN	-0.136989220604317
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/863	125/9376	0.956069524913094	RAC3/MAP2K2/FYN/MAPK13/CERS5/PRKCA/DEGS2/PPP2R1A/PPP2R1B/ROCK1/GAB2	-0.157425936441253
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/863	22/9376	0.987675129042452	ALDH7A1/MAOA	-0.0184265808845053
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/863	34/9376	0.958625860541204	POLR2H/POLR1D/POLR1E	-0.0769481566396711
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/863	216/9376	0.95566713874941	HSPA5/HSP90B1/CALM3/XBP1/JUN/CYP2J2/LDLR/HSPA2/HSPD1/FOS/HSP90AB1/MAPK13/PRKCA/CASP6/ERN1/EIF2S1/CCL3L1/POU2F1/LYN	-0.209872057288393
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/863	46/9376	0.944732732127563	PSMD11/PSMA4/PSMC4/PSMD3	-0.119634326545614
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/863	93/9376	0.934574315653073	CALM3/FXYD2/ADCY5/ATP1A1/ATP2B4/PRKCA/KCNN4/ITPR2	-0.201880928005511
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/863	139/9376	0.937936093766933	KRT19/HSP90B1/MMP2/CALM3/JUN/FOS/HSP90AB1/ADCY5/GRB2/KRT10/MAP2K2/ITPR2	-0.234709546221679
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/863	23/9376	0.944732732127563	B4GALT1/B3GALNT2	-0.0844901665169702
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/863	23/9376	0.944732732127563	ENPEP/REN	-0.0844901665169702
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/863	140/9376	0.931236550240026	RPS6/CALM3/MYL4/EGR1/ACTA2/ADCY5/TFAM/MAP2K2/GNB1/GNB2/ITPR2/CDH1	-0.260993343814709
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/863	71/9376	0.918120542490167	JUN/JAM3/MAPK13/ATP6V0A1/ATP6V1A/LYN	-0.220493434149354
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/863	163/9376	0.933140919463421	CCNE1/BIRC5/JUN/CCNA2/YWHAQ/BRAF/FOS/GRB2/MAP2K2/PCNA/MAPK13/PRKCA/TGFB1/JAK1	-0.274159554525627
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/863	48/9376	0.905368868288914	FXYD2/ATP1A1/HK1/SLC37A4	-0.209271507733115
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/863	107/9376	0.913830259581334	LDHA/SLC2A1/PKM/CALM3/PYGL/PFKP/GYS1/FOXO1/ITPR2	-0.285417075445859
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/863	49/9376	0.886891952609549	C1GALT1/GALNT2/B4GALT1/GALNT1	-0.252737843846022
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/863	73/9376	0.892966555024683	MGST1/ADH5/GSTP1/MAOA/MGST2/GSTA4	-0.292293489989288
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/863	37/9376	0.880899439416241	ADH5/MAOA/GSTZ1	-0.231107584985619
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/863	109/9376	0.897062731882594	SLC2A1/PPP1CB/PYGL/INSR/PPP1CC/PPP1CA/GYS1/FOXO1/GFPT1	-0.344164463130887
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/863	144/9376	0.905368868288914	TBPL1/PPIF/XBP1/PSMD11/PSMA4/PRKCA/ERN1/NOP56/ITPR2/PSMC4/PSMD3/DAB1	-0.364348596924403
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/863	12/9376	0.905368868288914	CD46	-0.10443442352829
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/863	62/9376	0.876163420924756	INSR/CRYAB/ADCY5/IGF1/FOXO1	-0.311477294426403
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/863	86/9376	0.884313778328707	CBLB/JUN/BRAF/GRB2/EIF4EBP1/MAP2K2/PRKCA	-0.343141088962087
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/863	214/9376	0.913830259581334	HLA-G/CALR/HLA-C/CCNB1/PDIA3/CALM3/CCNB2/CDK1/HLA-E/JUN/FOS/RAC3/MAP2K2/GNB1/GNB2/MAPK13/PRKCA/ITPR2	-0.40599085110387
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/863	26/9376	0.835725109189767	SLC19A1/SLC19A2	-0.267055652763145
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/863	217/9376	0.901196661522606	HSP90B1/BIRC5/KPNA2/JUN/MGST1/KPNB1/FOS/HSP90AB1/CDC6/ADCY5/GRB2/EIF4EBP1/FGF7/MAP2K2/PRKCA/MGST2/XIAP/GSTA4	-0.46884271912644
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/863	65/9376	0.835725109189767	ALDH7A1/AGPAT5/GLA/AGPAT4/LIPG	-0.423135459552059
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/863	149/9376	0.874987362641636	NDUFA4/NDUFB11/ADCY5/NDUFV3/GNB1/GNB2/MAPK13/NDUFS2/NDUFC1/PRKCA/ITPR2/NDUFA3	-0.489741053052928
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/863	196/9376	0.886891952609549	HLA-G/HLA-C/CALM3/HLA-E/JUN/RPS27A/FOS/TCF7L2/MAP2K2/GNB1/GNB2/MAPK13/CDK4/ITPR2/LYN/JAK1	-0.509506723728666
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/863	78/9376	0.835725109189767	JUN/FOS/MAPK13/MARCKSL1/TGFB1/JAK1	-0.46384559541553
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/863	66/9376	0.823062607535377	DHRS9/HSD17B12/HSD11B2/HSD17B7/SRD5A3	-0.459268299141426
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/863	103/9376	0.843838945201318	CALR/JUN/FOS/MAPK13/PPP2R1A/PPP2R1B/CCL3L1/TGFB1	-0.507377186191657
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/863	104/9376	0.835725109189767	PLA2G2A/LYPLA1/AGPAT5/CHPT1/PHOSPHO1/LPCAT1/PLA2G10/AGPAT4	-0.536353186005397
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/863	29/9376	0.749270787549447	CALM3/GNB1	-0.430543992229443
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/863	105/9376	0.827765822435579	TOMM20/JUN/RPS27A/PHB2/BNIP3/MFN1/EIF2S1/SAMM50	-0.565067609928732
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/863	178/9376	0.854505448722122	JUN/DKK1/APCDD1/SERPINF1/TCF7L2/RAC3/RUVBL1/CCND2/FRZB/PRKCA/SFRP1/CACYBP/DAAM1/AXIN1	-0.623964307218714
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/863	56/9376	0.776030458533355	BNIP3/SAR1A/HSPD1/SAR1B	-0.535210638675884
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/863	94/9376	0.809053031236902	HSP90B1/JUN/FOS/HSP90AB1/MAPK13/TRAF4/ANAPC5	-0.592387154478082
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/863	226/9376	0.8653082988956	CGA/CALM3/PPP1CB/JUN/BRAF/FOS/PPP1CC/FXYD2/ADCY5/RAC3/ATP1A1/PPP1R12A/MAP2K2/PDE4D/PPP1CA/ATP2B4/MYL9/ROCK1	-0.652580706601575
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/863	30/9376	0.724295094631132	SDHA/SUCLG2	-0.481550625774472
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/863	95/9376	0.800536683539672	JUN/FOS/ATP6V0A1/ATP6V1A/CXCL12/CCL3L1/TGFB1	-0.622124309051814
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/863	120/9376	0.814831981460023	CALM3/JUN/BRAF/RIPK2/GRB2/MAP2K2/MAPK13/SH2B2/SORT1	-0.64997200075746
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/863	16/9376	0.679026651216686	MAOA	-0.409110625918838
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/863	16/9376	0.679026651216686	GLA	-0.409110625918838
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/863	133/9376	0.816874166877216	HLA-G/HLA-C/HLA-E/BRAF/GRB2/RAC3/MAP2K2/FYN/GZMB/PRKCA	-0.677202693551721
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/863	31/9376	0.700930736739805	ALDH7A1/UGDH	-0.531022220339639
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/863	253/9376	0.858847938297785	ACTG1/JUN/RPS27A/FNBP1/BNIP3/ACTN1/IL1R1/ITGA5/RIPK2/ACTR3/ACTR2/VCL/MAPK13/DIAPH1/FOXO1/ITPR2/HK1/MYL9/ARPC1A/ROCK1	-0.724650119999913
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/863	300/9376	0.869154113557358	STMN1/JUN/IL1R1/INSR/BRAF/FOS/MAP3K8/FGFR1/GRB2/DUSP8/RAC3/IGF1/FGF7/MAP2K2/MAPK13/PRKCA/FGFR3/ECSIT/PDGFRB/FLT4/EFNA4/GADD45A/TGFB1/PDGFRA	-0.733370061788541
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/863	109/9376	0.79738909500675	JUN/IL1R1/FOS/HSP90AB1/MAPK13/IL2RB/TGFB1/JAK1	-0.677417174719774
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/863	59/9376	0.736571282675727	CGA/INSR/ADCY5/ABHD5	-0.646250354997553
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/863	17/9376	0.639083907027469	CA2	-0.474204535846725
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/863	32/9376	0.679026651216686	BIRC5/XIAP	-0.579064934668315
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/863	98/9376	0.776030458533355	CALM3/LDLR/ADCY5/ATP1A1/ATP2B4/PRKCA/ITPR2	-0.709617854269571
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/863	184/9376	0.826641140611618	SEMA6A/EPHB4/RAC3/FYN/SEMA4B/PRKCA/ENAH/PARD3/CXCL12/MYL9/EFNA4/EPHB3/ROCK1/ROBO1	-0.756135561929574
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/863	136/9376	0.798854883784336	CCNE1/CBLB/JUN/FOS/CD46/CCND2/CDK4/EIF2S1/IL2RB/JAK1	-0.752302803668144
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/863	60/9376	0.724295094631132	RAC3/MAP2K2/MAPK13/PRKCA	-0.682111070063922
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/863	86/9376	0.757983238567463	SLC2A1/FXYD2/ADCY5/ATP1A1/PRKCA/KCNN4	-0.717854675045075
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/863	47/9376	0.693474026774488	PKM/INSR/HK1	-0.670731004112107
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/863	33/9376	0.658450086028302	DHTKD1/GPT2	-0.625774259762473
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/863	18/9376	0.603579245525943	MMADHC	-0.535982777883903
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/863	100/9376	0.760509849362688	CCR7/CXCL14/IL10RB/CCL21/CXCL12/CCL3L1/IL2RB	-0.766579156580052
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/863	19/9376	0.571811916814051	GLB1	-0.59482988714765
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/863	19/9376	0.571811916814051	DHTKD1	-0.59482988714765
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/863	49/9376	0.665168964457162	JUN/ADCY5/MAOA	-0.748173767722314
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/863	115/9376	0.75578618570205	CYP2J2/BRAF/ADCY5/GNB1/GNB2/MAOA/PRKCA/ITPR2	-0.838957429239727
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/863	63/9376	0.689804852029649	PTGDS/PLA2G2A/CYP2J2/PLA2G10	-0.786520765021241
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/863	63/9376	0.689804852029649	TCF7L2/BMP4/GADD45A/AXIN1	-0.786520765021241
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/863	90/9376	0.724295094631132	JUN/FOS/MAP2K2/MAPK13/CD274/JAK1	-0.836760416840407
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/863	142/9376	0.765100452075139	JUN/IL1R1/FOS/GRB2/FYN/MAPK13/ITPR2/TGFB1/GAB2/JAK1	-0.898009926640274
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	11/863	155/9376	0.771023810413785	CCNE1/LDLR/BRAF/ADCY5/TCF7L2/MAP2K2/PBX1/CDK4/WDR5/ITPR2/AXIN1	-0.915201833262625
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	14/863	193/9376	0.788093108147863	CCR7/CXCL14/BRAF/ADCY5/GRB2/RAC3/GNB1/GNB2/CCL21/PARD3/CXCL12/CCL3L1/ROCK1/LYN	-0.947068001115342
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/863	65/9376	0.668580087351814	LDLR/ADCY5/PBX1/ITPR2	-0.853663736140242
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/863	105/9376	0.724295094631132	IL1R1/CCL21/ERC1/XIAP/CXCL12/GADD45A/LYN	-0.904535407115366
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/863	79/9376	0.68762192528272	MGST1/ADH5/GSTP1/MGST2/GSTA4	-0.887712618824622
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/863	38/9376	0.571811916814051	NNMT/NT5C	-0.842071869134382
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/863	68/9376	0.639083907027469	DHRS9/RDH11/ADH5/RDH13	-0.951003763807311
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/863	122/9376	0.712421404555212	FOS/ADCY5/GRB2/IGF1/MAP2K2/MAPK13/PRKCA/ITPR2	-1.01793827735401
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/863	109/9376	0.697715458130907	JUN/FOS/MAP3K8/MAP2K2/MAPK13/CCL3L1/JAK1	-1.01066988630866
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/863	69/9376	0.629821821418375	CALM3/ADCY5/REN/ITPR2	-0.982607833267334
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/863	97/9376	0.672026376461875	CALM3/FOS/ADCY5/GNB1/GNB2/PRKCA	-1.03376998192366
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/863	150/9376	0.724295094631132	CCNE1/BRAF/TCF7L2/GRB2/FGF7/MAP2K2/CDH1/GADD45A/TGFB1/AXIN1	-1.08375999785677
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/863	70/9376	0.620824366826684	MGST1/GSTP1/MGST2/GSTA4	-1.01381248665625
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/863	98/9376	0.665168964457162	CALM3/PPIP5K2/PIK3C2A/PRKCA/ITPR2/PIP5K1C	-1.06086782795933
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/863	115/9376	0.661312912489294	FOS/ADCY5/GNB1/GNB2/FYN/PRKCA/ITPR2	-1.16350522214115
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/863	44/9376	0.493837564521226	TBPL1/CDK7	-1.07146651614665
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/863	90/9376	0.603579245525943	INSR/ADCY5/EIF4EBP1/IGF1/FOXO1	-1.20313128021463
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/863	45/9376	0.482863396420754	ABCG2/ABCA7	-1.10712628130137
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/863	119/9376	0.639083907027469	JUN/FOS/MAP3K8/MAPK13/ITCH/MMP14/XIAP	-1.2615205094294
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/863	91/9376	0.59694650656412	ADCY5/GNB1/PDE4D/GNB2/PRKCA	-1.2301049077414
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/863	187/9376	0.697182444029966	JUN/TRIP6/RIPK2/HSP90AB1/MAPK13/MFN1/SUGT1/TXN2/ITPR2/XIAP/PKN2/JAK1	-1.33173387466441
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/863	78/9376	0.557150072793178	PPIP5K2/TPI1/PIK3C2A/PIP5K1C	-1.25042839567163
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/863	93/9376	0.584108947283171	JUN/FOS/MAPK13/IL2RB/JAK1	-1.2832952763085
Human Diseases	Substance dependence	hsa05034	Alcoholism	12/863	191/9376	0.682581764573841	CALM3/PPP1CB/BRAF/PPP1CC/ADCY5/GRB2/GNB1/PPP1CA/GNB2/MAOA/PKIA/HAT1	-1.41110293664938
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/863	30/9376	0.362147547315566	PIGF	-1.11408336145134
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/863	31/9376	0.350465368369902	ALDH7A1	-1.15330247754554
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/863	50/9376	0.434577056778679	CXCL12/TGFB1	-1.27632255144965
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/863	32/9376	0.339513325608343	IGBP1	-1.19157766339689
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/863	169/9376	0.642865468607513	HMGB1/RPS27A/BNIP3/VMP1/MAP2K2/IGBP1/ERN1/RAB33B/EIF2S1/GORASP2	-1.49164626263197
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/863	99/9376	0.548708405023585	KRT19/CFD/C1R/C1S/KRT10	-1.43721183057948
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/863	33/9376	0.329225043014151	STX5	-1.22896737783926
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/863	100/9376	0.543221320973349	GYPA/CD55/IL1R1/ITGA5/ITGA1	-1.46209359165791
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/863	101/9376	0.537842892052821	CALM3/ADCY5/TCF7L2/MAP2K2/PRKCA	-1.48676758520623
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/863	116/9376	0.561953090662085	SLC1A2/ADCY5/GNB1/GNB2/PRKCA/ITPR2	-1.51145019556441
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/863	34/9376	0.319541953513735	RORB	-1.26552462559117
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/863	173/9376	0.628001527136819	ACTG1/KPNA2/DNAJC3/MAP2K2/FDPS/PRKCA/CDK4/XPO1/EIF2S1/JAK1	-1.57234997073714
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/863	72/9376	0.452684434144457	ISG15/MAPK13/PIN1	-1.48429052977813
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/863	36/9376	0.301789622762972	UGDH	-1.33633034671821
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/863	89/9376	0.488288827841212	ADCY5/GNB1/GNB2/PRKCA	-1.5443008088373
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	21/863	323/9376	0.706355897240887	CCNE1/TPM1/STMN1/EZH2/ITGA5/IGF2BP1/GRB2/ZEB1/MAP2K2/CCND2/SOX4/PRKCA/FGFR3/CDCA5/PDGFRB/BRCA1/SLC7A1/EFNA4/ROCK1/PDGFRA/KIF23	-1.70992083329999
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/863	105/9376	0.517353639022237	CALM3/CBLB/JUN/MAPK13/ITPR2	-1.58347100148863
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/863	250/9376	0.651865585168019	LAPTM4B/CD63/CD164/NEU1/CLN8/CTSW/ATP6V0A1/CTSE/GLA/ATP6V1A/CTSV/SORT1/LITAF/AP3D1/GLB1	-1.77634144638895
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/863	79/9376	0.412573155169632	SLC1A2/ATP6V0A1/ATP6V1A	-1.66934322539829
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/863	144/9376	0.5281318398352	SCD/ADH5/TRA2A/ALDH7A1/TCF7L2/MAPK13/FOXO1	-1.81678586085434
NA	NA	hsa04081	Hormone signaling	12/863	219/9376	0.595311036683122	CGA/LEP/DIO2/RAMP1/INSR/GAST/ADCY5/IGF1/RAMP2/GNB1/GNB2/PTH1R	-1.92937448168607
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/863	83/9376	0.392690111546999	PXMP4/MPV17L2/FAR2	-1.76938014480653
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/863	83/9376	0.392690111546999	POLR2H/G3BP1/POLR1D	-1.76938014480653
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/863	44/9376	0.246918782260613	DYNLL1	-1.59415486450206
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/863	66/9376	0.329225043014151	JUN/TGFB1	-1.74109988459985
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/863	181/9376	0.54022009820554	NFYB/CALM3/HSPD1/RIPK2/IL10RB/MAPK13/ATP6V0A1/TGFB1/JAK1	-1.98867183590215
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/863	168/9376	0.517353639022237	LEP/GRB2/IL10RB/CCND2/PDGFRB/IL2RB/JAK1/PDGFRA	-2.0097902776161
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/863	183/9376	0.534316053416409	RAN/FBL/DKC1/GAR1/GNL3/XPO1/NOP56/RRP7A/XRN2	-2.02552636747398
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/863	70/9376	0.310412183413342	SLC2A1/LEP	-1.84377021606244
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/863	143/9376	0.455850059558055	C1R/SNRPD1/ACTN1/C1S/SNRPB/SSB	-2.08768468977091
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/863	56/9376	0.194007614633339	CCND2	-1.92604626734137
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/863	168/9376	0.452684434144457	PPIA/HMGB1/PYGL/HSP90AB1/CHMP4A/XIAP/JAK1	-2.27907965744531
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/863	62/9376	0.175232684184951	ITCH	-2.0744782678897
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/863	195/9376	0.445720058234543	HMGB1/ACTG1/PPIF/CLCN3/MAP2K2/MAPK13/PRKCA/HAT1	-2.49029727876855
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/863	254/9376	0.470506655961168	CALM3/PPIF/FGFR1/FGF7/ATP2B4/PRKCA/FGFR3/ITPR2/PDGFRB/FLT4/PDGFRA	-2.7238428578157
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/863	298/9376	0.473951488097553	CCR7/LEP/CXCL14/IL1R1/IL10RB/ACVRL1/CCL21/BMP4/TNFRSF21/CXCL12/CCL3L1/IL2RB/TGFB1	-2.93824874004024
NA	NA	hsa04082	Neuroactive ligand signaling	5/863	199/9376	0.272975538177562	SLC1A2/ADCY5/GNB1/GNB2/PRKCA	-3.30046335618456
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/863	370/9376	0.322996461119288	CGA/LEP/TMEM97/RLN2/GZMA/NPW/PAQR9/KISS1R/PTH1R/GAL/PGRMC1	-4.23034268010388
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/863	449/9376	0.0483938816011892	CALM3/GNB1	-6.57926452857614