ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 63/1489 175/18639 0.36 4.50640698455339 8.97500302961242e-26 1.01507284264917e-22 GO:0045296 cadherin binding 66/1489 334/18639 0.197604790419162 2.47357668812811 4.4325053137649e-12 2.50658175493405e-09 GO:0005201 extracellular matrix structural constituent 39/1489 168/18639 0.232142857142857 2.90591720234098 9.24420375238685e-10 3.4021486858088e-07 GO:0031720 haptoglobin binding 9/1489 10/18639 0.9 11.2660174613835 1.20323560948145e-09 3.4021486858088e-07 GO:0043021 ribonucleoprotein complex binding 39/1489 177/18639 0.220338983050847 2.75815870052703 4.5329485141839e-09 1.0253529539084e-06 GO:0019838 growth factor binding 33/1489 136/18639 0.242647058823529 3.03740666851025 5.49858063163317e-09 1.03648244906285e-06 GO:0004601 peroxidase activity 20/1489 57/18639 0.350877192982456 4.39220953660175 6.75164881917986e-09 1.05733825195034e-06 GO:0016853 isomerase activity 39/1489 180/18639 0.216666666666667 2.71218938885158 7.47896199434371e-09 1.05733825195034e-06 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 20/1489 59/18639 0.338983050847458 4.24332107773389 1.33479881441166e-08 1.67739717677732e-06 GO:0051082 unfolded protein binding 29/1489 121/18639 0.239669421487603 3.00013320826557 6.11088707035971e-08 6.91141327657683e-06 GO:0048027 mRNA 5'-UTR binding 12/1489 24/18639 0.5 6.25889858965749 7.05974399083255e-08 7.25870041239238e-06 GO:0043022 ribosome binding 27/1489 112/18639 0.241071428571429 3.01768324858486 1.52052451075792e-07 1.43309435138934e-05 GO:0005344 oxygen carrier activity 9/1489 14/18639 0.642857142857143 8.04715532955963 1.79140524901959e-07 1.55852256664704e-05 GO:0048407 platelet-derived growth factor binding 8/1489 11/18639 0.727272727272727 9.10385249404726 2.15947420382075e-07 1.74454666037233e-05 GO:0016860 intramolecular oxidoreductase activity 17/1489 53/18639 0.320754716981132 4.01514249147839 4.04171695221157e-07 3.04745458196752e-05 GO:0003756 protein disulfide isomerase activity 10/1489 19/18639 0.526315789473684 6.58831430490262 4.85433477756049e-07 3.22956037260054e-05 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 10/1489 19/18639 0.526315789473684 6.58831430490262 4.85433477756049e-07 3.22956037260054e-05 GO:0030020 extracellular matrix structural constituent conferring tensile strength 15/1489 44/18639 0.340909090909091 4.26743085658465 8.00716495348884e-07 5.03116864577549e-05 GO:0044183 protein folding chaperone 20/1489 75/18639 0.266666666666667 3.33807924781733 1.11050769376305e-06 6.61044316655796e-05 GO:0140662 ATP-dependent protein folding chaperone 14/1489 40/18639 0.35 4.38122901276024 1.29540004677806e-06 7.32548726452991e-05 GO:0016209 antioxidant activity 21/1489 86/18639 0.244186046511628 3.05667140425133 2.86214192443506e-06 0.000154146786501717 GO:0015035 protein-disulfide reductase activity 12/1489 34/18639 0.352941176470588 4.41804606328764 6.73456329890367e-06 0.000346217776866366 GO:0008017 microtubule binding 44/1489 276/18639 0.159420289855072 1.9955908546734 7.8661436051408e-06 0.000386809061626706 GO:0015631 tubulin binding 56/1489 385/18639 0.145454545454545 1.82077049880945 8.69977954477686e-06 0.00040997711104761 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 12/1489 36/18639 0.333333333333333 4.17259905977166 1.32266870375056e-05 0.000554051223682181 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 12/1489 36/18639 0.333333333333333 4.17259905977166 1.32266870375056e-05 0.000554051223682181 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 12/1489 36/18639 0.333333333333333 4.17259905977166 1.32266870375056e-05 0.000554051223682181 GO:0016859 cis-trans isomerase activity 13/1489 42/18639 0.30952380952381 3.87455626978797 1.44845331628325e-05 0.000585071678827268 GO:0001618 virus receptor activity 19/1489 81/18639 0.234567901234568 2.93627341243191 1.56418696613871e-05 0.000610032916794098 GO:0140272 exogenous protein binding 19/1489 82/18639 0.231707317073171 2.90046520008518 1.8851933100976e-05 0.000710717877906796 GO:0044389 ubiquitin-like protein ligase binding 48/1489 322/18639 0.149068322981366 1.86600703294136 1.96143085307406e-05 0.000715605901557021 GO:0180051 translation factor activity 19/1489 84/18639 0.226190476190476 2.83140650484505 2.7091751962508e-05 0.000957524108424891 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 12/1489 39/18639 0.307692307692308 3.85162990132769 3.29935560950494e-05 0.00113077914980306 GO:0031625 ubiquitin protein ligase binding 45/1489 302/18639 0.149006622516556 1.865234679037 3.55850675608751e-05 0.00118372680621617 GO:0140104 molecular carrier activity 39/1489 249/18639 0.156626506024096 1.96061883531439 3.79060561719944e-05 0.00120451209491966 GO:0019843 rRNA binding 16/1489 65/18639 0.246153846153846 3.08130392106215 3.83399075305993e-05 0.00120451209491966 GO:0015036 disulfide oxidoreductase activity 12/1489 40/18639 0.3 3.75533915379449 4.37291469700563e-05 0.00133669365467929 GO:0005178 integrin binding 28/1489 161/18639 0.173913043478261 2.17700820509826 7.27236757109273e-05 0.00216448624286997 GO:0008135 translation factor activity, RNA binding 18/1489 83/18639 0.216867469879518 2.71470300274301 7.88081929138021e-05 0.00228543759450026 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 6/1489 11/18639 0.545454545454545 6.82788937053544 8.36541326639733e-05 0.00236532060107385 GO:0003743 translation initiation factor activity 13/1489 51/18639 0.254901960784314 3.19081104570774 0.000137252642871836 0.00378616436800113 GO:0016887 ATP hydrolysis activity 55/1489 417/18639 0.13189448441247 1.65102840494562 0.000158413571821011 0.00426585118403721 GO:0140517 protein-RNA adaptor activity 8/1489 22/18639 0.363636363636364 4.55192624702363 0.000188102623683887 0.00494753645084828 GO:0003697 single-stranded DNA binding 22/1489 121/18639 0.181818181818182 2.27596312351181 0.000216195271177141 0.0055572011750306 GO:0019825 oxygen binding 10/1489 34/18639 0.294117647058824 3.6817050527397 0.000226780581478378 0.00569975194782323 GO:0003779 actin binding 57/1489 443/18639 0.128668171557562 1.61064207499087 0.000233967619449869 0.00575255168690874 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 13/1489 54/18639 0.240740740740741 3.01354376539064 0.000254968150160273 0.00613551016662274 GO:0008187 poly-pyrimidine tract binding 9/1489 30/18639 0.3 3.75533915379449 0.000395466260203075 0.00931817375603496 GO:0008301 DNA binding, bending 7/1489 19/18639 0.368421052631579 4.61182001343183 0.000437110676668474 0.00985721388347981 GO:0005161 platelet-derived growth factor receptor binding 6/1489 14/18639 0.428571428571429 5.36477021970642 0.000440776016186654 0.00985721388347981 GO:0005539 glycosaminoglycan binding 35/1489 242/18639 0.144628099173554 1.8104252118844 0.000444489750713944 0.00985721388347981 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 22/1489 128/18639 0.171875 2.15149639019476 0.000489410609115969 0.0106446807482723 GO:0050840 extracellular matrix binding 14/1489 67/18639 0.208955223880597 2.61565911209567 0.000709315960809363 0.0151365349372715 GO:0003725 double-stranded RNA binding 15/1489 75/18639 0.2 2.503559435863 0.000754805615120897 0.0158089842722544 GO:0008266 poly(U) RNA binding 8/1489 27/18639 0.296296296296296 3.70897694201925 0.000910815530981139 0.0187296793734485 GO:0046625 sphingolipid binding 8/1489 28/18639 0.285714285714286 3.57651347980428 0.00118677977146012 0.0239687128843106 GO:0042393 histone binding 34/1489 247/18639 0.137651821862348 1.72309758743607 0.00128378943387821 0.0254730850827412 GO:0004857 enzyme inhibitor activity 51/1489 416/18639 0.122596153846154 1.53463378881025 0.00144575391559004 0.0276029771773844 GO:0016018 cyclosporin A binding 6/1489 17/18639 0.352941176470588 4.41804606328764 0.00147409719591078 0.0276029771773844 GO:0051787 misfolded protein binding 6/1489 17/18639 0.352941176470588 4.41804606328764 0.00147409719591078 0.0276029771773844 GO:0005518 collagen binding 14/1489 72/18639 0.194444444444444 2.43401611820013 0.00148875473724178 0.0276029771773844 GO:0004602 glutathione peroxidase activity 7/1489 23/18639 0.304347826086957 3.80976435892195 0.00160165209227337 0.0287534685136696 GO:0017134 fibroblast growth factor binding 7/1489 23/18639 0.304347826086957 3.80976435892195 0.00160165209227337 0.0287534685136696 GO:0003727 single-stranded RNA binding 16/1489 89/18639 0.179775280898876 2.25039050414651 0.00169217085915604 0.0299038319016481 GO:0035401 histone H3Y41 kinase activity 19/1489 115/18639 0.165217391304348 2.06815779484334 0.00185785840974583 0.0318369372942808 GO:0140801 histone H2AXY142 kinase activity 19/1489 115/18639 0.165217391304348 2.06815779484334 0.00185785840974583 0.0318369372942808 GO:0030955 potassium ion binding 5/1489 13/18639 0.384615384615385 4.81453737665961 0.00241229998477297 0.0401222247467387 GO:0031994 insulin-like growth factor I binding 5/1489 13/18639 0.384615384615385 4.81453737665961 0.00241229998477297 0.0401222247467387 GO:0033218 amide binding 33/1489 247/18639 0.133603238866397 1.67241824662913 0.00245415055061327 0.0402267285904871 GO:0044325 transmembrane transporter binding 21/1489 136/18639 0.154411764705882 1.93289515268834 0.00260853376212571 0.0421464526423454 GO:0005520 insulin-like growth factor binding 6/1489 19/18639 0.315789473684211 3.95298858294157 0.00281331402472389 0.0448149036896157 GO:0030515 snoRNA binding 8/1489 32/18639 0.25 3.12944929482874 0.00301613704385615 0.047378486063907 GO:0019199 transmembrane receptor protein kinase activity 14/1489 78/18639 0.179487179487179 2.24678410910782 0.00325727962625843 0.0504655240725793 GO:0004713 protein tyrosine kinase activity 21/1489 140/18639 0.15 1.87766957689725 0.00371236893542271 0.0567390441346363 GO:0019842 vitamin binding 22/1489 150/18639 0.146666666666667 1.83594358629953 0.00399778075205307 0.0602865337409604 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 10/1489 48/18639 0.208333333333333 2.60787441235729 0.00405926975660286 0.0604083433515504 GO:0051015 actin filament binding 28/1489 209/18639 0.133971291866029 1.67702545942976 0.00480679694733948 0.0699796681860665 GO:0051087 protein-folding chaperone binding 20/1489 134/18639 0.149253731343284 1.86832793721119 0.00482618401283218 0.0699796681860665 GO:0070182 DNA polymerase binding 6/1489 21/18639 0.285714285714286 3.57651347980428 0.00490072615579156 0.0701610288886109 GO:0048029 monosaccharide binding 13/1489 74/18639 0.175675675675676 2.19907247744723 0.00542376264557919 0.0765862610846418 GO:0005007 fibroblast growth factor receptor activity 10/1489 50/18639 0.2 2.503559435863 0.00551295961269628 0.0765862610846418 GO:0017116 single-stranded DNA helicase activity 11/1489 58/18639 0.189655172413793 2.37406498228387 0.00562867144754513 0.0765862610846418 GO:0005522 profilin binding 4/1489 10/18639 0.4 5.00711887172599 0.0057558197985805 0.0765862610846418 GO:0005528 FK506 binding 4/1489 10/18639 0.4 5.00711887172599 0.0057558197985805 0.0765862610846418 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/1489 10/18639 0.4 5.00711887172599 0.0057558197985805 0.0765862610846418 GO:0070034 telomerase RNA binding 6/1489 22/18639 0.272727272727273 3.41394468526772 0.00629005218160575 0.0827215002022803 GO:0005030 neurotrophin receptor activity 10/1489 51/18639 0.196078431372549 2.4544700351598 0.00637774068510541 0.0829106289063704 GO:0003714 transcription corepressor activity 27/1489 204/18639 0.132352941176471 1.65676727373286 0.00652964110984251 0.0839207283549077 GO:0051861 glycolipid binding 7/1489 29/18639 0.241379310344828 3.02153725017948 0.00668531650751353 0.0849561007864922 GO:0019205 nucleobase-containing compound kinase activity 9/1489 44/18639 0.204545454545455 2.56045851395079 0.0071165324774527 0.0894310914666556 GO:0004714 transmembrane receptor protein tyrosine kinase activity 11/1489 60/18639 0.183333333333333 2.29492948287441 0.00732010806920331 0.0909784860029554 GO:0001968 fibronectin binding 7/1489 30/18639 0.233333333333333 2.92081934184016 0.00813065246766341 0.0988547915819268 GO:0035925 mRNA 3'-UTR AU-rich region binding 7/1489 30/18639 0.233333333333333 2.92081934184016 0.00813065246766341 0.0988547915819268 GO:0005003 ephrin receptor activity 10/1489 53/18639 0.188679245283019 2.36184852439905 0.0084201093916345 0.0988547915819268 GO:0005005 transmembrane-ephrin receptor activity 10/1489 53/18639 0.188679245283019 2.36184852439905 0.0084201093916345 0.0988547915819268 GO:0005536 D-glucose binding 4/1489 11/18639 0.363636363636364 4.55192624702363 0.00847826240799903 0.0988547915819268 GO:1990948 ubiquitin ligase inhibitor activity 4/1489 11/18639 0.363636363636364 4.55192624702363 0.00847826240799903 0.0988547915819268 GO:0004550 nucleoside diphosphate kinase activity 5/1489 17/18639 0.294117647058824 3.6817050527397 0.00886312640048122 0.102287713866778 GO:0000287 magnesium ion binding 29/1489 230/18639 0.126086956521739 1.57833094869624 0.0096208423822284 0.109910835700003 GO:0005540 hyaluronic acid binding 6/1489 24/18639 0.25 3.12944929482874 0.00989072128759974 0.110756492834409 GO:0060229 lipase activator activity 6/1489 24/18639 0.25 3.12944929482874 0.00989072128759974 0.110756492834409 GO:0008201 heparin binding 23/1489 172/18639 0.133720930232558 1.67389148328049 0.0101523614888643 0.112571772979466 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/1489 39/18639 0.205128205128205 2.56775326755179 0.0107265410167401 0.117783668834301 GO:0061749 forked DNA-dependent helicase activity 9/1489 47/18639 0.191489361702128 2.39702499178372 0.0110328910770045 0.118839998172306 GO:1990518 single-stranded 3'-5' DNA helicase activity 9/1489 47/18639 0.191489361702128 2.39702499178372 0.0110328910770045 0.118839998172306 GO:0015101 organic cation transmembrane transporter activity 13/1489 81/18639 0.160493827160494 2.00902917692709 0.0116031094178308 0.122592229083822 GO:0140142 nucleocytoplasmic carrier activity 7/1489 32/18639 0.21875 2.73826813297515 0.011691086413025 0.122592229083822 GO:0140097 catalytic activity, acting on DNA 39/1489 336/18639 0.116071428571429 1.45295860117049 0.0118382121474266 0.122592229083822 GO:0005527 macrolide binding 4/1489 12/18639 0.333333333333333 4.17259905977166 0.0119232053043505 0.122592229083822 GO:0031543 peptidyl-proline dioxygenase activity 4/1489 12/18639 0.333333333333333 4.17259905977166 0.0119232053043505 0.122592229083822 GO:1901681 sulfur compound binding 33/1489 275/18639 0.12 1.5021356615178 0.0123496055410283 0.124333173675799 GO:0043539 protein serine/threonine kinase activator activity 12/1489 73/18639 0.164383561643836 2.05772008427095 0.0124721476665324 0.124333173675799 GO:0009378 four-way junction helicase activity 9/1489 48/18639 0.1875 2.34708697112156 0.0126421883047895 0.124333173675799 GO:0036121 double-stranded DNA helicase activity 9/1489 48/18639 0.1875 2.34708697112156 0.0126421883047895 0.124333173675799 GO:0043138 3'-5' DNA helicase activity 9/1489 48/18639 0.1875 2.34708697112156 0.0126421883047895 0.124333173675799 GO:0003678 DNA helicase activity 12/1489 74/18639 0.162162162162162 2.02991305610513 0.0138363512189749 0.129433153930966 GO:0005004 GPI-linked ephrin receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0005008 hepatocyte growth factor receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0005009 insulin receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0005011 macrophage colony-stimulating factor receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0005018 platelet-derived growth factor alpha-receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0005020 stem cell factor receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0008288 boss receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0036332 placental growth factor receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0038062 protein tyrosine kinase collagen receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0060175 brain-derived neurotrophic factor receptor activity 9/1489 49/18639 0.183673469387755 2.29918723701704 0.0144196086607443 0.129433153930966 GO:0031420 alkali metal ion binding 5/1489 19/18639 0.263157894736842 3.29415715245131 0.014573324645332 0.129782914754886 GO:0051117 ATPase binding 13/1489 84/18639 0.154761904761905 1.93727813489398 0.015514256539348 0.137083001140646 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/1489 13/18639 0.307692307692308 3.85162990132769 0.0161502743352738 0.138207581701393 GO:0005542 folic acid binding 4/1489 13/18639 0.307692307692308 3.85162990132769 0.0161502743352738 0.138207581701393 GO:0019104 DNA N-glycosylase activity 4/1489 13/18639 0.307692307692308 3.85162990132769 0.0161502743352738 0.138207581701393 GO:0005006 epidermal growth factor receptor activity 9/1489 50/18639 0.18 2.2532034922767 0.0163747267444621 0.138207581701393 GO:0005017 platelet-derived growth factor receptor activity 9/1489 50/18639 0.18 2.2532034922767 0.0163747267444621 0.138207581701393 GO:0005019 platelet-derived growth factor beta-receptor activity 9/1489 50/18639 0.18 2.2532034922767 0.0163747267444621 0.138207581701393 GO:0098631 cell adhesion mediator activity 12/1489 76/18639 0.157894736842105 1.97649429147079 0.0169021624009163 0.141324232412008 GO:0016829 lyase activity 25/1489 200/18639 0.125 1.56472464741437 0.0169938953209842 0.141324232412008 GO:0008320 protein transmembrane transporter activity 6/1489 27/18639 0.222222222222222 2.78173270651444 0.0177207708547064 0.145435117545243 GO:0016004 phospholipase activator activity 5/1489 20/18639 0.25 3.12944929482874 0.0181809068507516 0.145435117545243 GO:0043024 ribosomal small subunit binding 5/1489 20/18639 0.25 3.12944929482874 0.0181809068507516 0.145435117545243 GO:0030145 manganese ion binding 11/1489 68/18639 0.161764705882353 2.02493777900683 0.018304269502955 0.145435117545243 GO:1990841 promoter-specific chromatin binding 11/1489 68/18639 0.161764705882353 2.02493777900683 0.018304269502955 0.145435117545243 GO:0005010 insulin-like growth factor receptor activity 9/1489 51/18639 0.176470588235294 2.20902303164382 0.0185169380428957 0.145435117545243 GO:0005021 vascular endothelial growth factor receptor activity 9/1489 51/18639 0.176470588235294 2.20902303164382 0.0185169380428957 0.145435117545243 GO:0005048 signal sequence binding 9/1489 51/18639 0.176470588235294 2.20902303164382 0.0185169380428957 0.145435117545243 GO:0003774 cytoskeletal motor activity 20/1489 153/18639 0.130718954248366 1.6363133567732 0.0197666034041514 0.154179506552381 GO:0019887 protein kinase regulator activity 30/1489 255/18639 0.117647058823529 1.47268202109588 0.0210840364985378 0.163166735908775 GO:1990825 sequence-specific mRNA binding 4/1489 14/18639 0.285714285714286 3.57651347980428 0.0212073476380106 0.163166735908775 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 10/1489 61/18639 0.163934426229508 2.05209789824836 0.0218837459329168 0.165595657547797 GO:0004869 cysteine-type endopeptidase inhibitor activity 7/1489 36/18639 0.194444444444444 2.43401611820013 0.0219622887994426 0.165595657547797 GO:0055106 ubiquitin-protein transferase regulator activity 7/1489 36/18639 0.194444444444444 2.43401611820013 0.0219622887994426 0.165595657547797 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/1489 21/18639 0.238095238095238 2.9804278998369 0.0223309633179266 0.166342171387186 GO:0097110 scaffold protein binding 11/1489 70/18639 0.157142857142857 1.96708241389235 0.0223554465524777 0.166342171387186 GO:0002020 protease binding 18/1489 136/18639 0.132352941176471 1.65676727373286 0.0232887151037307 0.171845785691585 GO:0038064 collagen receptor activity 9/1489 53/18639 0.169811320754717 2.12566367195915 0.0233989840817896 0.171845785691585 GO:0043236 laminin binding 6/1489 29/18639 0.206896551724138 2.58988907158241 0.0248226747127657 0.179964391667551 GO:0106222 lncRNA binding 6/1489 29/18639 0.206896551724138 2.58988907158241 0.0248226747127657 0.179964391667551 GO:0016758 hexosyltransferase activity 24/1489 197/18639 0.121827411167513 1.52501082387594 0.0251569654587612 0.18122629257235 GO:0022853 active monoatomic ion transmembrane transporter activity 16/1489 118/18639 0.135593220338983 1.69732843109356 0.0255168262831302 0.181997642558219 GO:0030246 carbohydrate binding 32/1489 280/18639 0.114285714285714 1.43060539192171 0.0255858754790068 0.181997642558219 GO:0140597 protein carrier chaperone 23/1489 188/18639 0.122340425531915 1.5314326336396 0.0267584923261221 0.187100837605835 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/1489 22/18639 0.227272727272727 2.84495390438977 0.027048878358021 0.187100837605835 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1489 15/18639 0.266666666666667 3.33807924781733 0.0271304486006693 0.187100837605835 GO:0048531 beta-1,3-galactosyltransferase activity 4/1489 15/18639 0.266666666666667 3.33807924781733 0.0271304486006693 0.187100837605835 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/1489 15/18639 0.266666666666667 3.33807924781733 0.0271304486006693 0.187100837605835 GO:0042162 telomeric DNA binding 7/1489 38/18639 0.184210526315789 2.30591000671592 0.0289183845274358 0.198222381215333 GO:0008094 ATP-dependent activity, acting on DNA 25/1489 210/18639 0.119047619047619 1.49021394991845 0.0290954707363277 0.198234803631245 GO:0031072 heat shock protein binding 17/1489 131/18639 0.129770992366412 1.62444696220118 0.0318372315651155 0.215616220958956 GO:0004866 endopeptidase inhibitor activity 20/1489 161/18639 0.124223602484472 1.55500586078447 0.0321389185118023 0.216363790695526 GO:0000217 DNA secondary structure binding 7/1489 39/18639 0.179487179487179 2.24678410910782 0.0328978502954005 0.21790824273074 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 7/1489 39/18639 0.179487179487179 2.24678410910782 0.0328978502954005 0.21790824273074 GO:0005200 structural constituent of cytoskeleton 15/1489 112/18639 0.133928571428571 1.67649069365826 0.0329463390866105 0.21790824273074 GO:0072349 modified amino acid transmembrane transporter activity 6/1489 31/18639 0.193548387096774 2.42279945406096 0.0336042176425665 0.219375033034181 GO:0005159 insulin-like growth factor receptor binding 4/1489 16/18639 0.25 3.12944929482874 0.033943970628631 0.219375033034181 GO:0005521 lamin binding 4/1489 16/18639 0.25 3.12944929482874 0.033943970628631 0.219375033034181 GO:0043023 ribosomal large subunit binding 4/1489 16/18639 0.25 3.12944929482874 0.033943970628631 0.219375033034181 GO:0019207 kinase regulator activity 32/1489 287/18639 0.111498257839721 1.3957125774846 0.034562269151017 0.222101854601138 GO:0140713 histone chaperone activity 20/1489 164/18639 0.121951219512195 1.52656063162378 0.0380250288006226 0.239948169547125 GO:0050431 transforming growth factor beta binding 5/1489 24/18639 0.208333333333333 2.60787441235729 0.0382673746864201 0.239948169547125 GO:0050699 WW domain binding 5/1489 24/18639 0.208333333333333 2.60787441235729 0.0382673746864201 0.239948169547125 GO:0008378 galactosyltransferase activity 6/1489 32/18639 0.1875 2.34708697112156 0.0386610940801531 0.239948169547125 GO:0022884 macromolecule transmembrane transporter activity 6/1489 32/18639 0.1875 2.34708697112156 0.0386610940801531 0.239948169547125 GO:0070717 poly-purine tract binding 6/1489 32/18639 0.1875 2.34708697112156 0.0386610940801531 0.239948169547125 GO:0001094 TFIID-class transcription factor complex binding 3/1489 10/18639 0.3 3.75533915379449 0.0398852837089828 0.239948169547125 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/1489 10/18639 0.3 3.75533915379449 0.0398852837089828 0.239948169547125 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/1489 10/18639 0.3 3.75533915379449 0.0398852837089828 0.239948169547125 GO:0043208 glycosphingolipid binding 3/1489 10/18639 0.3 3.75533915379449 0.0398852837089828 0.239948169547125 GO:0047429 nucleoside triphosphate diphosphatase activity 3/1489 10/18639 0.3 3.75533915379449 0.0398852837089828 0.239948169547125 GO:0098505 G-rich strand telomeric DNA binding 3/1489 10/18639 0.3 3.75533915379449 0.0398852837089828 0.239948169547125 GO:0017110 nucleoside diphosphate phosphatase activity 4/1489 17/18639 0.235294117647059 2.94536404219176 0.0416611534680617 0.247993497749357 GO:0070402 NADPH binding 4/1489 17/18639 0.235294117647059 2.94536404219176 0.0416611534680617 0.247993497749357 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/1489 41/18639 0.170731707317073 2.13718488427329 0.0419124812147103 0.248183331171923 GO:0015399 primary active transmembrane transporter activity 20/1489 166/18639 0.120481927710843 1.50816833485723 0.0423661606270563 0.249534273317952 GO:0003777 microtubule motor activity 10/1489 68/18639 0.147058823529412 1.84085252636985 0.0428025190306655 0.249534273317952 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/1489 68/18639 0.147058823529412 1.84085252636985 0.0428025190306655 0.249534273317952 GO:0009055 electron transfer activity 15/1489 116/18639 0.129310344827586 1.61868066973901 0.0430612905009886 0.249755484905734 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6/1489 33/18639 0.181818181818182 2.27596312351181 0.0441767531963984 0.253623897792521 GO:0140416 transcription regulator inhibitor activity 6/1489 33/18639 0.181818181818182 2.27596312351181 0.0441767531963984 0.253623897792521 GO:0019208 phosphatase regulator activity 15/1489 117/18639 0.128205128205128 1.60484579221987 0.0459005369147219 0.262189430558336 GO:0035198 miRNA binding 7/1489 42/18639 0.166666666666667 2.08629952988583 0.0469647505598692 0.265594358109724 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 9/1489 60/18639 0.15 1.87766957689725 0.047607107969737 0.265594358109724 GO:0016830 carbon-carbon lyase activity 8/1489 51/18639 0.156862745098039 1.96357602812784 0.0478669450396402 0.265594358109724 GO:0030544 Hsp70 protein binding 8/1489 51/18639 0.156862745098039 1.96357602812784 0.0478669450396402 0.265594358109724 GO:0030414 peptidase inhibitor activity 20/1489 169/18639 0.118343195266272 1.48139611589526 0.0495366109157037 0.265594358109724 GO:0016831 carboxy-lyase activity 6/1489 34/18639 0.176470588235294 2.20902303164382 0.0501592181934165 0.265594358109724 GO:0090482 vitamin transmembrane transporter activity 6/1489 34/18639 0.176470588235294 2.20902303164382 0.0501592181934165 0.265594358109724 GO:0003746 translation elongation factor activity 4/1489 18/18639 0.222222222222222 2.78173270651444 0.0502847444565565 0.265594358109724 GO:0008525 phosphatidylcholine transporter activity 4/1489 18/18639 0.222222222222222 2.78173270651444 0.0502847444565565 0.265594358109724 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/1489 18/18639 0.222222222222222 2.78173270651444 0.0502847444565565 0.265594358109724 GO:0003712 transcription coregulator activity 50/1489 495/18639 0.101010101010101 1.26442395750656 0.0507305205461031 0.265594358109724 GO:0004523 RNA-DNA hybrid ribonuclease activity 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0008526 phosphatidylinositol transfer activity 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0015173 aromatic amino acid transmembrane transporter activity 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0032050 clathrin heavy chain binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0032794 GTPase activating protein binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0034056 estrogen response element binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0034713 type I transforming growth factor beta receptor binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0048185 activin binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0050786 RAGE receptor binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0070990 snRNP binding 3/1489 11/18639 0.272727272727273 3.41394468526772 0.0516629166968517 0.265594358109724 GO:0008143 poly(A) binding 5/1489 26/18639 0.192307692307692 2.4072686883298 0.0519485090771626 0.265854134689009 GO:0003689 DNA clamp loader activity 19/1489 160/18639 0.11875 1.48648841504365 0.0529922695849614 0.269974130182844 GO:0003713 transcription coactivator activity 28/1489 256/18639 0.109375 1.36913406648758 0.0556927741298825 0.282459764757386 GO:0016229 steroid dehydrogenase activity 6/1489 35/18639 0.171428571428571 2.14590808788257 0.0566140644677477 0.284580030724545 GO:0061631 ubiquitin conjugating enzyme activity 6/1489 35/18639 0.171428571428571 2.14590808788257 0.0566140644677477 0.284580030724545 GO:0004364 glutathione transferase activity 5/1489 27/18639 0.185185185185185 2.31811058876203 0.0597275404913573 0.294098305197525 GO:0008574 plus-end-directed microtubule motor activity 4/1489 19/18639 0.210526315789474 2.63532572196105 0.0598077897395497 0.294098305197525 GO:0046624 sphingolipid transporter activity 4/1489 19/18639 0.210526315789474 2.63532572196105 0.0598077897395497 0.294098305197525 GO:0050145 nucleoside monophosphate kinase activity 4/1489 19/18639 0.210526315789474 2.63532572196105 0.0598077897395497 0.294098305197525 GO:0097001 ceramide binding 4/1489 19/18639 0.210526315789474 2.63532572196105 0.0598077897395497 0.294098305197525 GO:0061134 peptidase regulator activity 25/1489 226/18639 0.110619469026549 1.38471207735785 0.0607565892843354 0.297470573509019 GO:1901682 sulfur compound transmembrane transporter activity 9/1489 63/18639 0.142857142857143 1.78825673990214 0.0617583701479759 0.300345348211227 GO:0061135 endopeptidase regulator activity 21/1489 184/18639 0.114130434782609 1.42866163459573 0.0618748595342316 0.300345348211227 GO:0061775 cohesin loader activity 18/1489 153/18639 0.117647058823529 1.47268202109588 0.062871994534564 0.302109588391408 GO:0017069 snRNA binding 8/1489 54/18639 0.148148148148148 1.85448847100963 0.0635393364271204 0.302109588391408 GO:0005049 nuclear export signal receptor activity 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0005095 GTPase inhibitor activity 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0017166 vinculin binding 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0043047 single-stranded telomeric DNA binding 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0045295 gamma-catenin binding 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/1489 12/18639 0.25 3.12944929482874 0.0649094871610188 0.302109588391408 GO:0097718 disordered domain specific binding 5/1489 28/18639 0.178571428571429 2.23532092487767 0.0681313280236712 0.315805458994968 GO:0003684 damaged DNA binding 10/1489 74/18639 0.135135135135135 1.69159421342094 0.0691498506197318 0.317757707318822 GO:0031491 nucleosome binding 10/1489 74/18639 0.135135135135135 1.69159421342094 0.0691498506197318 0.317757707318822 GO:0098632 cell-cell adhesion mediator activity 8/1489 55/18639 0.145454545454545 1.82077049880945 0.0693953613684784 0.317757707318822 GO:0031418 L-ascorbic acid binding 4/1489 20/18639 0.2 2.503559435863 0.0702145104617493 0.318926149928668 GO:0061608 nuclear import signal receptor activity 4/1489 20/18639 0.2 2.503559435863 0.0702145104617493 0.318926149928668 GO:0038024 cargo receptor activity 9/1489 65/18639 0.138461538461538 1.73323345559746 0.0725370156281386 0.328157458701699 GO:0004867 serine-type endopeptidase inhibitor activity 12/1489 95/18639 0.126315789473684 1.58119543317663 0.0754231563324308 0.339168287651761 GO:0030170 pyridoxal phosphate binding 8/1489 56/18639 0.142857142857143 1.78825673990214 0.075570652951586 0.339168287651761 GO:0003785 actin monomer binding 5/1489 29/18639 0.172413793103448 2.15824089298534 0.0771539641301098 0.343547769413993 GO:0035250 UDP-galactosyltransferase activity 5/1489 29/18639 0.172413793103448 2.15824089298534 0.0771539641301098 0.343547769413993 GO:0140297 DNA-binding transcription factor binding 48/1489 488/18639 0.0983606557377049 1.23125873894901 0.0778503662676176 0.345289271563433 GO:0042887 amide transmembrane transporter activity 6/1489 38/18639 0.157894736842105 1.97649429147079 0.0788321018233975 0.345987041888029 GO:0008253 5'-nucleotidase activity 3/1489 13/18639 0.230769230769231 2.88872242599576 0.0795372510087423 0.345987041888029 GO:0043560 insulin receptor substrate binding 3/1489 13/18639 0.230769230769231 2.88872242599576 0.0795372510087423 0.345987041888029 GO:0061459 L-arginine transmembrane transporter activity 3/1489 13/18639 0.230769230769231 2.88872242599576 0.0795372510087423 0.345987041888029 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/1489 13/18639 0.230769230769231 2.88872242599576 0.0795372510087423 0.345987041888029 GO:0140658 ATP-dependent chromatin remodeler activity 18/1489 158/18639 0.113924050632911 1.42607815966879 0.0802742427309237 0.347855051834003 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/1489 21/18639 0.19047619047619 2.38434231986952 0.0814812274367664 0.351737665003751 GO:0070279 vitamin B6 binding 8/1489 57/18639 0.140350877192982 1.7568838146407 0.0820656729255593 0.352913597257824 GO:0016500 protein-hormone receptor activity 9/1489 67/18639 0.134328358208955 1.68149514349007 0.084408647898673 0.361614321111361 GO:0016769 transferase activity, transferring nitrogenous groups 5/1489 30/18639 0.166666666666667 2.08629952988583 0.0867856209013235 0.369138932736953 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 20/1489 181/18639 0.110497237569061 1.38318200876409 0.0868178214925105 0.369138932736953 GO:0061980 regulatory RNA binding 8/1489 58/18639 0.137931034482759 1.72659271438827 0.0888798653534684 0.376491115036602 GO:0000510 H3-H4 histone complex chaperone activity 17/1489 151/18639 0.112582781456954 1.40928842416129 0.0947728786404232 0.393439112490831 GO:0140584 chromatin extrusion motor activity 17/1489 151/18639 0.112582781456954 1.40928842416129 0.0947728786404232 0.393439112490831 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 17/1489 151/18639 0.112582781456954 1.40928842416129 0.0947728786404232 0.393439112490831 GO:0140849 ATP-dependent H2AZ histone chaperone activity 17/1489 151/18639 0.112582781456954 1.40928842416129 0.0947728786404232 0.393439112490831 GO:0019992 diacylglycerol binding 3/1489 14/18639 0.214285714285714 2.68238510985321 0.0954454064734873 0.393439112490831 GO:0044548 S100 protein binding 3/1489 14/18639 0.214285714285714 2.68238510985321 0.0954454064734873 0.393439112490831 GO:0098847 sequence-specific single stranded DNA binding 3/1489 14/18639 0.214285714285714 2.68238510985321 0.0954454064734873 0.393439112490831 GO:0004532 RNA exonuclease activity 6/1489 40/18639 0.15 1.87766957689725 0.0959998401418063 0.393439112490831 GO:0070063 RNA polymerase binding 8/1489 59/18639 0.135593220338983 1.69732843109356 0.0960116667086378 0.393439112490831 GO:0032182 ubiquitin-like protein binding 14/1489 120/18639 0.116666666666667 1.46040967092008 0.0975075981632477 0.398126691417448 GO:0015616 DNA translocase activity 17/1489 152/18639 0.111842105263158 1.40001678979181 0.0991856310801912 0.402075085131528 GO:0140674 ATP-dependent histone chaperone activity 17/1489 152/18639 0.111842105263158 1.40001678979181 0.0991856310801912 0.402075085131528 GO:0043130 ubiquitin binding 12/1489 100/18639 0.12 1.5021356615178 0.101462879158689 0.409837558315989 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/1489 41/18639 0.146341463414634 1.83187275794853 0.105271958815023 0.41810121125137 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/1489 41/18639 0.146341463414634 1.83187275794853 0.105271958815023 0.41810121125137 GO:0140318 protein transporter activity 6/1489 41/18639 0.146341463414634 1.83187275794853 0.105271958815023 0.41810121125137 GO:0005212 structural constituent of eye lens 4/1489 23/18639 0.173913043478261 2.17700820509826 0.106466090928731 0.41810121125137 GO:0042171 lysophosphatidic acid acyltransferase activity 4/1489 23/18639 0.173913043478261 2.17700820509826 0.106466090928731 0.41810121125137 GO:0070577 lysine-acetylated histone binding 4/1489 23/18639 0.173913043478261 2.17700820509826 0.106466090928731 0.41810121125137 GO:0071617 lysophospholipid acyltransferase activity 4/1489 23/18639 0.173913043478261 2.17700820509826 0.106466090928731 0.41810121125137 GO:0140103 catalytic activity, acting on a glycoprotein 4/1489 23/18639 0.173913043478261 2.17700820509826 0.106466090928731 0.41810121125137 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/1489 32/18639 0.15625 1.95590580926797 0.107818687864505 0.421947875345172 GO:0005506 iron ion binding 17/1489 154/18639 0.11038961038961 1.38183475356074 0.10839050651634 0.422722975413724 GO:0031406 carboxylic acid binding 20/1489 187/18639 0.106951871657754 1.33880183735989 0.110968877890881 0.431291412008887 GO:0004559 alpha-mannosidase activity 3/1489 15/18639 0.2 2.503559435863 0.112524145941692 0.432873500204264 GO:0008252 nucleotidase activity 3/1489 15/18639 0.2 2.503559435863 0.112524145941692 0.432873500204264 GO:0016846 carbon-sulfur lyase activity 3/1489 15/18639 0.2 2.503559435863 0.112524145941692 0.432873500204264 GO:0004386 helicase activity 17/1489 155/18639 0.109677419354839 1.37291969063455 0.113182510611065 0.433930235596998 GO:0008307 structural constituent of muscle 6/1489 42/18639 0.142857142857143 1.78825673990214 0.114989826857548 0.437890552780765 GO:0031492 nucleosomal DNA binding 6/1489 42/18639 0.142857142857143 1.78825673990214 0.114989826857548 0.437890552780765 GO:0015179 L-amino acid transmembrane transporter activity 8/1489 62/18639 0.129032258064516 1.61519963604064 0.119282350127852 0.451294679250516 GO:0043177 organic acid binding 20/1489 189/18639 0.105820105820106 1.32463462214973 0.11985817834238 0.451294679250516 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/1489 24/18639 0.166666666666667 2.08629952988583 0.120105834177193 0.451294679250516 GO:0140033 acetylation-dependent protein binding 4/1489 24/18639 0.166666666666667 2.08629952988583 0.120105834177193 0.451294679250516 GO:0016757 glycosyltransferase activity 27/1489 267/18639 0.101123595505618 1.26584465858241 0.121723604069878 0.455858927824611 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/1489 43/18639 0.13953488372093 1.7466693738579 0.125141256301343 0.464048396317438 GO:0008375 acetylglucosaminyltransferase activity 6/1489 43/18639 0.13953488372093 1.7466693738579 0.125141256301343 0.464048396317438 GO:0048156 tau protein binding 6/1489 43/18639 0.13953488372093 1.7466693738579 0.125141256301343 0.464048396317438 GO:0003688 DNA replication origin binding 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0004708 MAP kinase kinase activity 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0005024 transforming growth factor beta receptor activity 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0015923 mannosidase activity 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0017070 U6 snRNA binding 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0097027 ubiquitin-protein transferase activator activity 3/1489 16/18639 0.1875 2.34708697112156 0.130658032552398 0.473635368002443 GO:0008376 acetylgalactosaminyltransferase activity 5/1489 34/18639 0.147058823529412 1.84085252636985 0.13108402610038 0.473661448944183 GO:0051020 GTPase binding 31/1489 315/18639 0.0984126984126984 1.23191019859925 0.132823431323823 0.478187394070015 GO:0008139 nuclear localization sequence binding 4/1489 25/18639 0.16 2.0028475486904 0.134450567032949 0.478187394070015 GO:0015662 P-type ion transporter activity 4/1489 25/18639 0.16 2.0028475486904 0.134450567032949 0.478187394070015 GO:0019211 phosphatase activator activity 4/1489 25/18639 0.16 2.0028475486904 0.134450567032949 0.478187394070015 GO:0140358 P-type transmembrane transporter activity 4/1489 25/18639 0.16 2.0028475486904 0.134450567032949 0.478187394070015 GO:0001046 core promoter sequence-specific DNA binding 6/1489 44/18639 0.136363636363636 1.70697234263386 0.135712319573412 0.481161860305732 GO:0140463 chromatin-protein adaptor activity 7/1489 54/18639 0.12962962962963 1.62267741213342 0.136976734224111 0.484127145023341 GO:0042277 peptide binding 25/1489 249/18639 0.100401606425703 1.25680694571436 0.13987130037132 0.492817572336334 GO:0031490 chromatin DNA binding 14/1489 128/18639 0.109375 1.36913406648758 0.142662323509371 0.501090335059312 GO:0000175 3'-5'-RNA exonuclease activity 5/1489 35/18639 0.142857142857143 1.78825673990214 0.143495686372485 0.502457031849166 GO:0019888 protein phosphatase regulator activity 12/1489 107/18639 0.11214953271028 1.40386510422224 0.14585494282188 0.509141791146748 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1489 45/18639 0.133333333333333 1.66903962390866 0.146687491459033 0.509409168996456 GO:0140313 molecular sequestering activity 7/1489 55/18639 0.127272727272727 1.59317418645827 0.14683235109889 0.509409168996456 GO:0070006 metalloaminopeptidase activity 4/1489 26/18639 0.153846153846154 1.92581495066384 0.149450941206728 0.511611069954214 GO:0120014 phospholipid transfer activity 4/1489 26/18639 0.153846153846154 1.92581495066384 0.149450941206728 0.511611069954214 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1489 17/18639 0.176470588235294 2.20902303164382 0.149728792356185 0.511611069954214 GO:0005092 GDP-dissociation inhibitor activity 3/1489 17/18639 0.176470588235294 2.20902303164382 0.149728792356185 0.511611069954214 GO:0032977 membrane insertase activity 3/1489 17/18639 0.176470588235294 2.20902303164382 0.149728792356185 0.511611069954214 GO:0019212 phosphatase inhibitor activity 7/1489 56/18639 0.125 1.56472464741437 0.157012593691362 0.534883263448586 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/1489 46/18639 0.130434782608696 1.63275615382369 0.158049795799236 0.536799756903712 GO:0020037 heme binding 15/1489 142/18639 0.105633802816901 1.32230251894172 0.162374547314904 0.549837164710051 GO:0001671 ATPase activator activity 4/1489 27/18639 0.148148148148148 1.85448847100963 0.165055010896357 0.555586956320775 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1489 27/18639 0.148148148148148 1.85448847100963 0.165055010896357 0.555586956320775 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1489 18/18639 0.166666666666667 2.08629952988583 0.16961760193611 0.562573336626805 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/1489 18/18639 0.166666666666667 2.08629952988583 0.16961760193611 0.562573336626805 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1489 18/18639 0.166666666666667 2.08629952988583 0.16961760193611 0.562573336626805 GO:0098641 cadherin binding involved in cell-cell adhesion 3/1489 18/18639 0.166666666666667 2.08629952988583 0.16961760193611 0.562573336626805 GO:1901611 phosphatidylglycerol binding 3/1489 18/18639 0.166666666666667 2.08629952988583 0.16961760193611 0.562573336626805 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/1489 122/18639 0.10655737704918 1.33386363386143 0.175738999393608 0.581171954135002 GO:0016835 carbon-oxygen lyase activity 9/1489 79/18639 0.113924050632911 1.42607815966879 0.17789213420694 0.582385434171036 GO:0008408 3'-5' exonuclease activity 7/1489 58/18639 0.120689655172414 1.51076862508974 0.178296870063589 0.582385434171036 GO:0008514 organic anion transmembrane transporter activity 26/1489 269/18639 0.0966542750929368 1.2098986121271 0.18014891432032 0.582385434171036 GO:0016866 intramolecular transferase activity 4/1489 28/18639 0.142857142857143 1.78825673990214 0.181208958041805 0.582385434171036 GO:0046875 ephrin receptor binding 4/1489 28/18639 0.142857142857143 1.78825673990214 0.181208958041805 0.582385434171036 GO:0008194 UDP-glycosyltransferase activity 15/1489 145/18639 0.103448275862069 1.2949445357912 0.182267492685264 0.582385434171036 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/1489 38/18639 0.131578947368421 1.64707857622565 0.183515146747714 0.582385434171036 GO:0000049 tRNA binding 9/1489 80/18639 0.1125 1.40825218267294 0.187260185555304 0.582385434171036 GO:0004382 GDP phosphatase activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0016427 tRNA (cytidine) methyltransferase activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0016783 sulfurtransferase activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0016868 intramolecular phosphotransferase activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0031434 mitogen-activated protein kinase kinase binding 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0035374 chondroitin sulfate binding 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0042975 peroxisome proliferator activated receptor binding 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0043121 neurotrophin binding 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0051880 G-quadruplex DNA binding 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0097177 mitochondrial ribosome binding 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:1990757 ubiquitin ligase activator activity 2/1489 10/18639 0.2 2.503559435863 0.18743439260677 0.582385434171036 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/1489 19/18639 0.157894736842105 1.97649429147079 0.190206941722965 0.587770631389819 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/1489 19/18639 0.157894736842105 1.97649429147079 0.190206941722965 0.587770631389819 GO:0060590 ATPase regulator activity 6/1489 49/18639 0.122448979591837 1.53279149134469 0.194271127396632 0.598693855819048 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/1489 29/18639 0.137931034482759 1.72659271438827 0.197857757067677 0.606442068410684 GO:0097472 cyclin-dependent protein kinase activity 4/1489 29/18639 0.137931034482759 1.72659271438827 0.197857757067677 0.606442068410684 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 7/1489 60/18639 0.116666666666667 1.46040967092008 0.200721015252596 0.611901531673009 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/1489 60/18639 0.116666666666667 1.46040967092008 0.200721015252596 0.611901531673009 GO:0140299 molecular sensor activity 8/1489 71/18639 0.112676056338028 1.4104560202045 0.204531793899186 0.621842631451557 GO:0000339 RNA cap binding 3/1489 20/18639 0.15 1.87766957689725 0.211382076651415 0.632679166196102 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/1489 20/18639 0.15 1.87766957689725 0.211382076651415 0.632679166196102 GO:0004177 aminopeptidase activity 5/1489 40/18639 0.125 1.56472464741437 0.212207478418864 0.632679166196102 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/1489 40/18639 0.125 1.56472464741437 0.212207478418864 0.632679166196102 GO:0050997 quaternary ammonium group binding 5/1489 40/18639 0.125 1.56472464741437 0.212207478418864 0.632679166196102 GO:0061791 GTPase motor activity 5/1489 40/18639 0.125 1.56472464741437 0.212207478418864 0.632679166196102 GO:1990606 membrane scission GTPase motor activity 5/1489 40/18639 0.125 1.56472464741437 0.212207478418864 0.632679166196102 GO:0000099 sulfur amino acid transmembrane transporter activity 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0002162 dystroglycan binding 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0005114 type II transforming growth factor beta receptor binding 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0008046 axon guidance receptor activity 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0034511 U3 snoRNA binding 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0042608 T cell receptor binding 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0050998 nitric-oxide synthase binding 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0097493 structural molecule activity conferring elasticity 2/1489 11/18639 0.181818181818182 2.27596312351181 0.217605831697863 0.632679166196102 GO:0030295 protein kinase activator activity 14/1489 139/18639 0.100719424460432 1.26078532741302 0.220113428884012 0.638328943763634 GO:0004527 exonuclease activity 9/1489 84/18639 0.107142857142857 1.3411925549266 0.226751538153917 0.651787933915833 GO:0004860 protein kinase inhibitor activity 9/1489 84/18639 0.107142857142857 1.3411925549266 0.226751538153917 0.651787933915833 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/1489 41/18639 0.121951219512195 1.52656063162378 0.227059633919397 0.651787933915833 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/1489 41/18639 0.121951219512195 1.52656063162378 0.227059633919397 0.651787933915833 GO:0016411 acylglycerol O-acyltransferase activity 4/1489 31/18639 0.129032258064516 1.61519963604064 0.232417328265331 0.65625492889838 GO:0017147 Wnt-protein binding 4/1489 31/18639 0.129032258064516 1.61519963604064 0.232417328265331 0.65625492889838 GO:0046906 tetrapyrrole binding 15/1489 152/18639 0.0986842105263158 1.23530893216924 0.232953603798456 0.65625492889838 GO:0015174 basic amino acid transmembrane transporter activity 3/1489 21/18639 0.142857142857143 1.78825673990214 0.23303221818719 0.65625492889838 GO:0019200 carbohydrate kinase activity 3/1489 21/18639 0.142857142857143 1.78825673990214 0.23303221818719 0.65625492889838 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1489 21/18639 0.142857142857143 1.78825673990214 0.23303221818719 0.65625492889838 GO:0072542 protein phosphatase activator activity 3/1489 21/18639 0.142857142857143 1.78825673990214 0.23303221818719 0.65625492889838 GO:0005080 protein kinase C binding 6/1489 52/18639 0.115384615384615 1.44436121299788 0.233257720085897 0.65625492889838 GO:0016798 hydrolase activity, acting on glycosyl bonds 13/1489 130/18639 0.1 1.2517797179315 0.238663674105303 0.669798053134239 GO:0048487 beta-tubulin binding 5/1489 42/18639 0.119047619047619 1.49021394991845 0.242204202441269 0.676270141649441 GO:0140296 general transcription initiation factor binding 6/1489 53/18639 0.113207547169811 1.41710911463943 0.246764185856855 0.676270141649441 GO:0050660 flavin adenine dinucleotide binding 9/1489 86/18639 0.104651162790698 1.31000203039343 0.24757768797459 0.676270141649441 GO:0003720 telomerase activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0005078 MAP-kinase scaffold activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0008179 adenylate cyclase binding 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0015132 prostaglandin transmembrane transporter activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0016423 tRNA (guanine) methyltransferase activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0016801 hydrolase activity, acting on ether bonds 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0016803 ether hydrolase activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0016840 carbon-nitrogen lyase activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0035251 UDP-glucosyltransferase activity 2/1489 12/18639 0.166666666666667 2.08629952988583 0.248145100605232 0.676270141649441 GO:0042910 xenobiotic transmembrane transporter activity 4/1489 32/18639 0.125 1.56472464741437 0.250217134036878 0.680277833162761 GO:0140784 metal ion sensor activity 3/1489 22/18639 0.136363636363636 1.70697234263386 0.255051415004669 0.690668975102783 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 13/1489 132/18639 0.0984848484848485 1.2328133585689 0.255639324180407 0.690668975102783 GO:0042626 ATPase-coupled transmembrane transporter activity 10/1489 98/18639 0.102040816326531 1.27732624278724 0.255871176452755 0.690668975102783 GO:0003925 G protein activity 6/1489 54/18639 0.111111111111111 1.39086635325722 0.260487617310948 0.698131505162753 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/1489 54/18639 0.111111111111111 1.39086635325722 0.260487617310948 0.698131505162753 GO:0050661 NADP binding 6/1489 54/18639 0.111111111111111 1.39086635325722 0.260487617310948 0.698131505162753 GO:0051540 metal cluster binding 8/1489 77/18639 0.103896103896104 1.30055035629247 0.271644382201652 0.718277935890857 GO:0003954 NADH dehydrogenase activity 5/1489 44/18639 0.113636363636364 1.42247695219488 0.273234773221077 0.718277935890857 GO:0030547 signaling receptor inhibitor activity 5/1489 44/18639 0.113636363636364 1.42247695219488 0.273234773221077 0.718277935890857 GO:0043014 alpha-tubulin binding 5/1489 44/18639 0.113636363636364 1.42247695219488 0.273234773221077 0.718277935890857 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/1489 23/18639 0.130434782608696 1.63275615382369 0.27733921361606 0.718277935890857 GO:0008171 O-methyltransferase activity 3/1489 23/18639 0.130434782608696 1.63275615382369 0.27733921361606 0.718277935890857 GO:0043274 phospholipase binding 3/1489 23/18639 0.130434782608696 1.63275615382369 0.27733921361606 0.718277935890857 GO:0003964 RNA-directed DNA polymerase activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0008035 high-density lipoprotein particle binding 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0019855 calcium channel inhibitor activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0035673 oligopeptide transmembrane transporter activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0039706 co-receptor binding 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0071714 icosanoid transmembrane transporter activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0089720 caspase binding 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0140666 annealing activity 2/1489 13/18639 0.153846153846154 1.92581495066384 0.278801073259139 0.718277935890857 GO:0008175 tRNA methyltransferase activity 4/1489 34/18639 0.117647058823529 1.47268202109588 0.286584995368069 0.734983287440559 GO:0030332 cyclin binding 4/1489 34/18639 0.117647058823529 1.47268202109588 0.286584995368069 0.734983287440559 GO:0046915 transition metal ion transmembrane transporter activity 5/1489 45/18639 0.111111111111111 1.39086635325722 0.289053183441333 0.739636087041058 GO:0019210 kinase inhibitor activity 9/1489 90/18639 0.1 1.2517797179315 0.290984566131783 0.742897391185206 GO:0019209 kinase activator activity 14/1489 148/18639 0.0945945945945946 1.18411594939466 0.294149730548225 0.749286813626223 GO:0046332 SMAD binding 8/1489 79/18639 0.10126582278481 1.26762503081671 0.2952932368576 0.750509327833585 GO:0015171 amino acid transmembrane transporter activity 10/1489 102/18639 0.0980392156862745 1.2272350175799 0.296972757395705 0.751871264492793 GO:0005548 phospholipid transporter activity 7/1489 68/18639 0.102941176470588 1.28859676845889 0.299299994530242 0.751871264492793 GO:0015149 hexose transmembrane transporter activity 3/1489 24/18639 0.125 1.56472464741437 0.29980112496447 0.751871264492793 GO:0015295 solute:proton symporter activity 3/1489 24/18639 0.125 1.56472464741437 0.29980112496447 0.751871264492793 GO:0055056 D-glucose transmembrane transporter activity 3/1489 24/18639 0.125 1.56472464741437 0.29980112496447 0.751871264492793 GO:0016922 nuclear receptor binding 13/1489 137/18639 0.0948905109489051 1.18782017029996 0.299817807503315 0.751871264492793 GO:0030276 clathrin binding 5/1489 46/18639 0.108695652173913 1.36063012818641 0.305029206324515 0.759932681291452 GO:0005154 epidermal growth factor receptor binding 4/1489 35/18639 0.114285714285714 1.43060539192171 0.305048132012661 0.759932681291452 GO:0140566 histone reader activity 4/1489 35/18639 0.114285714285714 1.43060539192171 0.305048132012661 0.759932681291452 GO:0008191 metalloendopeptidase inhibitor activity 2/1489 14/18639 0.142857142857143 1.78825673990214 0.309360351056748 0.760622950098222 GO:0008559 ABC-type xenobiotic transporter activity 2/1489 14/18639 0.142857142857143 1.78825673990214 0.309360351056748 0.760622950098222 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/1489 14/18639 0.142857142857143 1.78825673990214 0.309360351056748 0.760622950098222 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1489 14/18639 0.142857142857143 1.78825673990214 0.309360351056748 0.760622950098222 GO:0032036 myosin heavy chain binding 2/1489 14/18639 0.142857142857143 1.78825673990214 0.309360351056748 0.760622950098222 GO:1901474 azole transmembrane transporter activity 2/1489 14/18639 0.142857142857143 1.78825673990214 0.309360351056748 0.760622950098222 GO:0001221 transcription coregulator binding 11/1489 115/18639 0.0956521739130435 1.19735451280404 0.31179820997353 0.7649539598266 GO:0052689 carboxylic ester hydrolase activity 9/1489 92/18639 0.0978260869565217 1.22456711536777 0.313393322298165 0.767203133158494 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0140791 histone H2AXS140 phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1489 81/18639 0.0987654320987654 1.23632564733975 0.319401878666356 0.767349752611813 GO:0005504 fatty acid binding 5/1489 47/18639 0.106382978723404 1.33168055099096 0.321130188610968 0.767349752611813 GO:0004709 MAP kinase kinase kinase activity 3/1489 25/18639 0.12 1.5021356615178 0.322348928318768 0.767349752611813 GO:0005537 D-mannose binding 3/1489 25/18639 0.12 1.5021356615178 0.322348928318768 0.767349752611813 GO:0008483 transaminase activity 3/1489 25/18639 0.12 1.5021356615178 0.322348928318768 0.767349752611813 GO:0042974 nuclear retinoic acid receptor binding 3/1489 25/18639 0.12 1.5021356615178 0.322348928318768 0.767349752611813 GO:0004190 aspartic-type endopeptidase activity 4/1489 36/18639 0.111111111111111 1.39086635325722 0.323630267016653 0.767349752611813 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1489 36/18639 0.111111111111111 1.39086635325722 0.323630267016653 0.767349752611813 GO:0036002 pre-mRNA binding 6/1489 59/18639 0.101694915254237 1.27299632332017 0.331540052587239 0.779180642464912 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1489 82/18639 0.0975609756097561 1.22124850529902 0.3315945089415 0.779180642464912 GO:0033549 MAP kinase phosphatase activity 8/1489 82/18639 0.0975609756097561 1.22124850529902 0.3315945089415 0.779180642464912 GO:0004252 serine-type endopeptidase activity 16/1489 176/18639 0.0909090909090909 1.13798156175591 0.332059137904955 0.779180642464912 GO:0035591 signaling adaptor activity 12/1489 129/18639 0.0930232558139535 1.1644462492386 0.334584556059134 0.779180642464912 GO:0000774 adenyl-nucleotide exchange factor activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0004129 cytochrome-c oxidase activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0005041 low-density lipoprotein particle receptor activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0031005 filamin binding 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0031386 protein tag activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0034483 heparan sulfate sulfotransferase activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0120283 protein serine/threonine kinase binding 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0141047 molecular tag activity 2/1489 15/18639 0.133333333333333 1.66903962390866 0.339642844151372 0.779180642464912 GO:0043394 proteoglycan binding 4/1489 37/18639 0.108108108108108 1.35327537073675 0.342283504001793 0.779703967797916 GO:0070001 aspartic-type peptidase activity 4/1489 37/18639 0.108108108108108 1.35327537073675 0.342283504001793 0.779703967797916 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1489 83/18639 0.0963855421686747 1.20653466788578 0.343861226676355 0.779703967797916 GO:0005160 transforming growth factor beta receptor binding 3/1489 26/18639 0.115384615384615 1.44436121299788 0.344900839681208 0.779703967797916 GO:0015145 monosaccharide transmembrane transporter activity 3/1489 26/18639 0.115384615384615 1.44436121299788 0.344900839681208 0.779703967797916 GO:0050681 nuclear androgen receptor binding 3/1489 26/18639 0.115384615384615 1.44436121299788 0.344900839681208 0.779703967797916 GO:0070412 R-SMAD binding 3/1489 26/18639 0.115384615384615 1.44436121299788 0.344900839681208 0.779703967797916 GO:0001098 basal transcription machinery binding 6/1489 60/18639 0.1 1.2517797179315 0.346075501179977 0.779703967797916 GO:0001099 basal RNA polymerase II transcription machinery binding 6/1489 60/18639 0.1 1.2517797179315 0.346075501179977 0.779703967797916 GO:0003730 mRNA 3'-UTR binding 23/1489 262/18639 0.0877862595419847 1.09889059207727 0.349278165645745 0.785355080209419 GO:0017018 myosin phosphatase activity 8/1489 84/18639 0.0952380952380952 1.19217115993476 0.356188562310296 0.798014180530687 GO:0022804 active transmembrane transporter activity 39/1489 457/18639 0.0853391684901532 1.06825840261113 0.356319329061005 0.798014180530687 GO:0035173 histone kinase activity 31/1489 360/18639 0.0861111111111111 1.07792142377435 0.357570794529516 0.799234325321902 GO:0016407 acetyltransferase activity 9/1489 96/18639 0.09375 1.17354348556078 0.359181472375796 0.801250976838314 GO:0043531 ADP binding 4/1489 38/18639 0.105263157894737 1.31766286098052 0.360962134266978 0.80211522321493 GO:0019903 protein phosphatase binding 13/1489 144/18639 0.0902777777777778 1.13007891202149 0.364743108215158 0.80211522321493 GO:0005385 zinc ion transmembrane transporter activity 3/1489 27/18639 0.111111111111111 1.39086635325722 0.367381568279314 0.80211522321493 GO:0023026 MHC class II protein complex binding 3/1489 27/18639 0.111111111111111 1.39086635325722 0.367381568279314 0.80211522321493 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0008142 oxysterol binding 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0015562 efflux transmembrane transporter activity 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0019841 retinol binding 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0022858 alanine transmembrane transporter activity 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0030275 LRR domain binding 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0070411 I-SMAD binding 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0140328 floppase activity 2/1489 16/18639 0.125 1.56472464741437 0.36949781723694 0.80211522321493 GO:0045499 chemorepellent activity 3/1489 28/18639 0.107142857142857 1.3411925549266 0.389722281507815 0.836814842758807 GO:0051119 sugar transmembrane transporter activity 3/1489 28/18639 0.107142857142857 1.3411925549266 0.389722281507815 0.836814842758807 GO:0051537 2 iron, 2 sulfur cluster binding 3/1489 28/18639 0.107142857142857 1.3411925549266 0.389722281507815 0.836814842758807 GO:0019003 GDP binding 7/1489 75/18639 0.0933333333333333 1.16832773673606 0.392145782834092 0.836814842758807 GO:0030331 nuclear estrogen receptor binding 4/1489 40/18639 0.1 1.2517797179315 0.398224475155848 0.836814842758807 GO:0071949 FAD binding 4/1489 40/18639 0.1 1.2517797179315 0.398224475155848 0.836814842758807 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0004659 prenyltransferase activity 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0008429 phosphatidylethanolamine binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0015278 intracellularly gated calcium channel activity 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0030169 low-density lipoprotein particle binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0032183 SUMO binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0045236 CXCR chemokine receptor binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0046965 nuclear retinoid X receptor binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0048038 quinone binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0070492 oligosaccharide binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:1990226 histone methyltransferase binding 2/1489 17/18639 0.117647058823529 1.47268202109588 0.398800353887707 0.836814842758807 GO:0030159 signaling receptor complex adaptor activity 5/1489 52/18639 0.0961538461538462 1.2036343441649 0.402425293727946 0.842857420752421 GO:0051536 iron-sulfur cluster binding 7/1489 76/18639 0.0921052631578947 1.15295500335796 0.40554919958493 0.847830212071267 GO:0140996 histone H3 kinase activity 30/1489 357/18639 0.0840336134453782 1.0519157293542 0.413409215205509 0.862667568998949 GO:0001530 lipopolysaccharide binding 4/1489 41/18639 0.0975609756097561 1.22124850529902 0.416728782316545 0.864017940652135 GO:0017080 sodium channel regulator activity 4/1489 41/18639 0.0975609756097561 1.22124850529902 0.416728782316545 0.864017940652135 GO:0042169 SH2 domain binding 4/1489 41/18639 0.0975609756097561 1.22124850529902 0.416728782316545 0.864017940652135 GO:0004864 protein phosphatase inhibitor activity 5/1489 53/18639 0.0943396226415094 1.18092426219953 0.418639992464518 0.864017940652135 GO:0005246 calcium channel regulator activity 5/1489 53/18639 0.0943396226415094 1.18092426219953 0.418639992464518 0.864017940652135 GO:0051018 protein kinase A binding 5/1489 53/18639 0.0943396226415094 1.18092426219953 0.418639992464518 0.864017940652135 GO:0004674 protein serine/threonine kinase activity 36/1489 433/18639 0.0831408775981524 1.04074064308392 0.426084865238815 0.866386938717121 GO:0000400 four-way junction DNA binding 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0004706 JUN kinase kinase kinase activity 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0008409 5'-3' exonuclease activity 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0015172 acidic amino acid transmembrane transporter activity 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0016854 racemase and epimerase activity 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0030228 lipoprotein particle receptor activity 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0031690 adrenergic receptor binding 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0034185 apolipoprotein binding 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0070628 proteasome binding 2/1489 18/18639 0.111111111111111 1.39086635325722 0.427448197881656 0.866386938717121 GO:0070851 growth factor receptor binding 12/1489 139/18639 0.0863309352517986 1.08067313778259 0.433640218953208 0.870969669574115 GO:0031210 phosphatidylcholine binding 3/1489 30/18639 0.1 1.2517797179315 0.433739908960731 0.870969669574115 GO:0098918 structural constituent of synapse 3/1489 30/18639 0.1 1.2517797179315 0.433739908960731 0.870969669574115 GO:0046943 carboxylic acid transmembrane transporter activity 16/1489 188/18639 0.0851063829787234 1.06534444079276 0.433805394715401 0.870969669574115 GO:0051287 NAD binding 5/1489 54/18639 0.0925925925925926 1.15905529438102 0.434777989929168 0.870969669574115 GO:0004520 DNA endonuclease activity 4/1489 42/18639 0.0952380952380952 1.19217115993476 0.435099790724469 0.870969669574115 GO:0042056 chemoattractant activity 4/1489 42/18639 0.0952380952380952 1.19217115993476 0.435099790724469 0.870969669574115 GO:0042826 histone deacetylase binding 11/1489 127/18639 0.0866141732283465 1.08421865332649 0.435895186480711 0.871020240123117 GO:0017124 SH3 domain binding 10/1489 115/18639 0.0869565217391304 1.08850410254913 0.438219160872917 0.874119701847035 GO:0004722 protein serine/threonine phosphatase activity 9/1489 103/18639 0.087378640776699 1.09378810304694 0.440615231562014 0.877351807916615 GO:0005342 organic acid transmembrane transporter activity 16/1489 189/18639 0.0846560846560847 1.05970769771979 0.442378968603927 0.879172698478711 GO:0072341 modified amino acid binding 8/1489 91/18639 0.0879120879120879 1.10046568609362 0.443084383848687 0.879172698478711 GO:0033293 monocarboxylic acid binding 7/1489 79/18639 0.0886075949367089 1.10917190196462 0.445622628983151 0.88266058385279 GO:0019001 guanyl nucleotide binding 33/1489 400/18639 0.0825 1.03271826729349 0.449691832637127 0.883380710533909 GO:0032561 guanyl ribonucleotide binding 33/1489 400/18639 0.0825 1.03271826729349 0.449691832637127 0.883380710533909 GO:0008374 O-acyltransferase activity 5/1489 55/18639 0.0909090909090909 1.13798156175591 0.4508153300537 0.883380710533909 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/1489 31/18639 0.0967741935483871 1.21139972703048 0.455310185463809 0.883380710533909 GO:0070325 lipoprotein particle receptor binding 3/1489 31/18639 0.0967741935483871 1.21139972703048 0.455310185463809 0.883380710533909 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0016918 retinal binding 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0030506 ankyrin binding 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0042800 histone H3K4 methyltransferase activity 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0043395 heparan sulfate proteoglycan binding 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0046527 glucosyltransferase activity 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0140036 ubiquitin-modified protein reader activity 2/1489 19/18639 0.105263157894737 1.31766286098052 0.455358933900326 0.883380710533909 GO:0048306 calcium-dependent protein binding 7/1489 80/18639 0.0875 1.09530725319006 0.458886739096992 0.888700174518319 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 19/1489 229/18639 0.0829694323144105 1.03859452579469 0.466488148354046 0.900573438889581 GO:0005525 GTP binding 31/1489 378/18639 0.082010582010582 1.02659183216604 0.466610110689031 0.900573438889581 GO:0141003 histone H2AX kinase activity 29/1489 354/18639 0.0819209039548023 1.02546926045236 0.471982611538187 0.909390687648533 GO:0016247 channel regulator activity 14/1489 168/18639 0.0833333333333333 1.04314976494291 0.475192484397589 0.909640721194997 GO:0031369 translation initiation factor binding 3/1489 32/18639 0.09375 1.17354348556078 0.476526708025216 0.909640721194997 GO:0043425 bHLH transcription factor binding 3/1489 32/18639 0.09375 1.17354348556078 0.476526708025216 0.909640721194997 GO:0071813 lipoprotein particle binding 3/1489 32/18639 0.09375 1.17354348556078 0.476526708025216 0.909640721194997 GO:0071814 protein-lipid complex binding 3/1489 32/18639 0.09375 1.17354348556078 0.476526708025216 0.909640721194997 GO:0002039 p53 binding 6/1489 69/18639 0.0869565217391304 1.08850410254913 0.476938061599145 0.909640721194997 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/1489 20/18639 0.1 1.2517797179315 0.48246747359465 0.911005177835051 GO:0015095 magnesium ion transmembrane transporter activity 2/1489 20/18639 0.1 1.2517797179315 0.48246747359465 0.911005177835051 GO:0016408 C-acyltransferase activity 2/1489 20/18639 0.1 1.2517797179315 0.48246747359465 0.911005177835051 GO:0030742 GTP-dependent protein binding 2/1489 20/18639 0.1 1.2517797179315 0.48246747359465 0.911005177835051 GO:0042288 MHC class I protein binding 2/1489 20/18639 0.1 1.2517797179315 0.48246747359465 0.911005177835051 GO:0016504 peptidase activator activity 5/1489 57/18639 0.087719298245614 1.09805238415044 0.482499042383893 0.911005177835051 GO:0019955 cytokine binding 12/1489 144/18639 0.0833333333333333 1.04314976494291 0.483291871530531 0.911005177835051 GO:0008236 serine-type peptidase activity 16/1489 194/18639 0.0824742268041237 1.03239564365484 0.485103246916523 0.912898123565038 GO:0005179 hormone activity 11/1489 132/18639 0.0833333333333333 1.04314976494291 0.487815849914674 0.91583353194663 GO:0008009 chemokine activity 4/1489 45/18639 0.0888888888888889 1.11269308260578 0.489092354815 0.91583353194663 GO:0042605 peptide antigen binding 4/1489 45/18639 0.0888888888888889 1.11269308260578 0.489092354815 0.91583353194663 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/1489 70/18639 0.0857142857142857 1.07295404394128 0.491136592949974 0.918141300208959 GO:0141108 transporter regulator activity 14/1489 170/18639 0.0823529411764706 1.03087741476712 0.493401903579718 0.92071306160884 GO:0019956 chemokine binding 3/1489 33/18639 0.0909090909090909 1.13798156175591 0.497350302458786 0.92071306160884 GO:0071889 14-3-3 protein binding 3/1489 33/18639 0.0909090909090909 1.13798156175591 0.497350302458786 0.92071306160884 GO:0031267 small GTPase binding 23/1489 283/18639 0.0812720848056537 1.01734747393726 0.497461582455713 0.92071306160884 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/1489 58/18639 0.0862068965517241 1.07912044649267 0.498104380355364 0.92071306160884 GO:0005496 steroid binding 9/1489 108/18639 0.0833333333333333 1.04314976494291 0.498172602295323 0.92071306160884 GO:0001540 amyloid-beta binding 7/1489 83/18639 0.0843373493975904 1.05571783440006 0.498210781348019 0.92071306160884 GO:0004540 RNA nuclease activity 10/1489 121/18639 0.0826446280991736 1.03452869250537 0.503507989105325 0.928984560649466 GO:0001846 opsonin binding 2/1489 21/18639 0.0952380952380952 1.19217115993476 0.508723816269119 0.930921383943995 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1489 21/18639 0.0952380952380952 1.19217115993476 0.508723816269119 0.930921383943995 GO:0036122 BMP binding 2/1489 21/18639 0.0952380952380952 1.19217115993476 0.508723816269119 0.930921383943995 GO:0051010 microtubule plus-end binding 2/1489 21/18639 0.0952380952380952 1.19217115993476 0.508723816269119 0.930921383943995 GO:0061891 calcium ion sensor activity 2/1489 21/18639 0.0952380952380952 1.19217115993476 0.508723816269119 0.930921383943995 GO:0015078 proton transmembrane transporter activity 15/1489 185/18639 0.0810810810810811 1.01495652805257 0.51530127853393 0.930921383943995 GO:0015020 glucuronosyltransferase activity 3/1489 34/18639 0.0882352941176471 1.10451151582191 0.517746945080469 0.930921383943995 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/1489 34/18639 0.0882352941176471 1.10451151582191 0.517746945080469 0.930921383943995 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1489 34/18639 0.0882352941176471 1.10451151582191 0.517746945080469 0.930921383943995 GO:0017171 serine hydrolase activity 16/1489 198/18639 0.0808080808080808 1.01153916600525 0.518884871149595 0.930921383943995 GO:0042379 chemokine receptor binding 6/1489 72/18639 0.0833333333333333 1.04314976494291 0.519132709128931 0.930921383943995 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 28/1489 349/18639 0.0802292263610315 1.00429318344074 0.519495468538779 0.930921383943995 GO:0004222 metalloendopeptidase activity 9/1489 110/18639 0.0818181818181818 1.02418340558032 0.520755693584683 0.930921383943995 GO:0043495 protein-membrane adaptor activity 4/1489 47/18639 0.0851063829787234 1.06534444079276 0.523877247305857 0.930921383943995 GO:0140359 ABC-type transporter activity 4/1489 47/18639 0.0851063829787234 1.06534444079276 0.523877247305857 0.930921383943995 GO:0140789 histone phosphatase activity 11/1489 136/18639 0.0808823529411765 1.01246888950342 0.528570548873188 0.930921383943995 GO:0005243 gap junction channel activity 2/1489 22/18639 0.0909090909090909 1.13798156175591 0.534091056395564 0.930921383943995 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/1489 22/18639 0.0909090909090909 1.13798156175591 0.534091056395564 0.930921383943995 GO:0033691 sialic acid binding 2/1489 22/18639 0.0909090909090909 1.13798156175591 0.534091056395564 0.930921383943995 GO:0050321 tau-protein kinase activity 2/1489 22/18639 0.0909090909090909 1.13798156175591 0.534091056395564 0.930921383943995 GO:0140035 ubiquitin-like protein reader activity 2/1489 22/18639 0.0909090909090909 1.13798156175591 0.534091056395564 0.930921383943995 GO:0043015 gamma-tubulin binding 3/1489 35/18639 0.0857142857142857 1.07295404394128 0.537687458805575 0.930921383943995 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/1489 48/18639 0.0833333333333333 1.04314976494291 0.540836613666234 0.930921383943995 GO:0140693 molecular condensate scaffold activity 4/1489 48/18639 0.0833333333333333 1.04314976494291 0.540836613666234 0.930921383943995 GO:0015026 coreceptor activity 5/1489 61/18639 0.0819672131147541 1.02604894912418 0.543757298162634 0.930921383943995 GO:0035064 methylated histone binding 6/1489 74/18639 0.0810810810810811 1.01495652805257 0.546505422940326 0.930921383943995 GO:0004175 endopeptidase activity 32/1489 405/18639 0.0790123456790123 0.9890605178718 0.553221930117868 0.930921383943995 GO:0000993 RNA polymerase II complex binding 3/1489 36/18639 0.0833333333333333 1.04314976494291 0.55714720351366 0.930921383943995 GO:0001222 transcription corepressor binding 4/1489 49/18639 0.0816326530612245 1.02186099422979 0.557481623744121 0.930921383943995 GO:0005158 insulin receptor binding 2/1489 23/18639 0.0869565217391304 1.08850410254913 0.558543612850755 0.930921383943995 GO:0005283 amino acid:sodium symporter activity 2/1489 23/18639 0.0869565217391304 1.08850410254913 0.558543612850755 0.930921383943995 GO:0016493 C-C chemokine receptor activity 2/1489 23/18639 0.0869565217391304 1.08850410254913 0.558543612850755 0.930921383943995 GO:0099186 structural constituent of postsynapse 2/1489 23/18639 0.0869565217391304 1.08850410254913 0.558543612850755 0.930921383943995 GO:0000182 rDNA binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0005131 growth hormone receptor binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0005381 iron ion transmembrane transporter activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0008190 eukaryotic initiation factor 4E binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0008239 dipeptidyl-peptidase activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0015203 polyamine transmembrane transporter activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0030957 Tat protein binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0031996 thioesterase binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0032052 bile acid binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0032356 oxidized DNA binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0035256 G protein-coupled glutamate receptor binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0043295 glutathione binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0050815 phosphoserine residue binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0099122 RNA polymerase II C-terminal domain binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0140940 histone H2A methyltransferase activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:1905394 retromer complex binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:1990259 histone H2AQ104 methyltransferase activity 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:1990763 arrestin family protein binding 1/1489 10/18639 0.1 1.2517797179315 0.565165399883633 0.930921383943995 GO:0046982 protein heterodimerization activity 29/1489 369/18639 0.0785907859078591 0.983783518157546 0.565232818985059 0.930921383943995 GO:0003924 GTPase activity 26/1489 331/18639 0.0785498489425982 0.983271077529273 0.56585692503375 0.930921383943995 GO:0005507 copper ion binding 5/1489 63/18639 0.0793650793650794 0.9934759666123 0.573069886589311 0.930921383943995 GO:0017022 myosin binding 6/1489 76/18639 0.0789473684210526 0.988247145735393 0.573160468977092 0.930921383943995 GO:0140034 methylation-dependent protein binding 6/1489 76/18639 0.0789473684210526 0.988247145735393 0.573160468977092 0.930921383943995 GO:0023023 MHC protein complex binding 3/1489 37/18639 0.0810810810810811 1.01495652805257 0.576105765235295 0.930921383943995 GO:0030551 cyclic nucleotide binding 3/1489 37/18639 0.0810810810810811 1.01495652805257 0.576105765235295 0.930921383943995 GO:0016874 ligase activity 13/1489 167/18639 0.0778443113772455 0.974439301383801 0.5804816840008 0.930921383943995 GO:0004622 lysophospholipase activity 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0005315 phosphate transmembrane transporter activity 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0019957 C-C chemokine binding 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0030215 semaphorin receptor binding 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0035035 histone acetyltransferase binding 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1489 24/18639 0.0833333333333333 1.04314976494291 0.582065657204054 0.930921383943995 GO:0004536 DNA nuclease activity 5/1489 64/18639 0.078125 0.977952904633983 0.587350330368298 0.930921383943995 GO:0005096 GTPase activator activity 21/1489 271/18639 0.0774907749077491 0.970013803563153 0.591056744609968 0.930921383943995 GO:0000146 microfilament motor activity 3/1489 38/18639 0.0789473684210526 0.988247145735393 0.594546647889722 0.930921383943995 GO:0005109 frizzled binding 3/1489 38/18639 0.0789473684210526 0.988247145735393 0.594546647889722 0.930921383943995 GO:0005501 retinoid binding 3/1489 38/18639 0.0789473684210526 0.988247145735393 0.594546647889722 0.930921383943995 GO:0019840 isoprenoid binding 3/1489 38/18639 0.0789473684210526 0.988247145735393 0.594546647889722 0.930921383943995 GO:1990782 protein tyrosine kinase binding 9/1489 117/18639 0.0769230769230769 0.962907475331921 0.596711096926182 0.930921383943995 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/1489 91/18639 0.0769230769230769 0.962907475331921 0.597670195148675 0.930921383943995 GO:0003953 NAD+ nucleosidase activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0004016 adenylate cyclase activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0005225 volume-sensitive anion channel activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0008172 S-methyltransferase activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0008199 ferric iron binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0008432 JUN kinase binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0010854 adenylate cyclase regulator activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0019107 myristoyltransferase activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0019206 nucleoside kinase activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0032404 mismatch repair complex binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0043522 leucine zipper domain binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0045294 alpha-catenin binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0070697 activin receptor binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0140031 phosphorylation-dependent protein binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0180030 inositol phosphate kinase activity 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:1900750 oligopeptide binding 1/1489 11/18639 0.0909090909090909 1.13798156175591 0.59992135670221 0.930921383943995 GO:0000030 mannosyltransferase activity 2/1489 25/18639 0.08 1.0014237743452 0.604649720585384 0.930921383943995 GO:0001848 complement binding 2/1489 25/18639 0.08 1.0014237743452 0.604649720585384 0.930921383943995 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1489 25/18639 0.08 1.0014237743452 0.604649720585384 0.930921383943995 GO:0017025 TBP-class protein binding 2/1489 25/18639 0.08 1.0014237743452 0.604649720585384 0.930921383943995 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1489 25/18639 0.08 1.0014237743452 0.604649720585384 0.930921383943995 GO:0019707 protein-cysteine S-acyltransferase activity 2/1489 25/18639 0.08 1.0014237743452 0.604649720585384 0.930921383943995 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1489 52/18639 0.0769230769230769 0.962907475331921 0.605376543166778 0.930921383943995 GO:0004518 nuclease activity 16/1489 209/18639 0.076555023923445 0.95830026253129 0.608109108613356 0.930921383943995 GO:0043178 alcohol binding 7/1489 92/18639 0.0760869565217391 0.952441089730487 0.609383606576905 0.930921383943995 GO:0008235 metalloexopeptidase activity 5/1489 66/18639 0.0757575757575758 0.948317968129922 0.615107190297733 0.930921383943995 GO:0008013 beta-catenin binding 8/1489 106/18639 0.0754716981132075 0.944739409759621 0.618783398780395 0.930921383943995 GO:0017046 peptide hormone binding 4/1489 53/18639 0.0754716981132075 0.944739409759621 0.620620343224105 0.930921383943995 GO:0051213 dioxygenase activity 7/1489 93/18639 0.0752688172043011 0.942199787690375 0.620912971743524 0.930921383943995 GO:0051219 phosphoprotein binding 7/1489 93/18639 0.0752688172043011 0.942199787690375 0.620912971743524 0.930921383943995 GO:0015293 symporter activity 11/1489 146/18639 0.0753424657534247 0.943121705290854 0.62494394499877 0.930921383943995 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0004529 DNA exonuclease activity 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0004950 chemokine receptor activity 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0008157 protein phosphatase 1 binding 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0034237 protein kinase A regulatory subunit binding 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0050750 low-density lipoprotein particle receptor binding 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0052742 phosphatidylinositol kinase activity 2/1489 26/18639 0.0769230769230769 0.962907475331921 0.626295460660731 0.930921383943995 GO:0008173 RNA methyltransferase activity 5/1489 67/18639 0.0746268656716418 0.934163968605595 0.628566291520209 0.930921383943995 GO:0015144 carbohydrate transmembrane transporter activity 3/1489 40/18639 0.075 0.938834788448623 0.62982717292288 0.930921383943995 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/1489 40/18639 0.075 0.938834788448623 0.62982717292288 0.930921383943995 GO:0000340 RNA 7-methylguanosine cap binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0003995 acyl-CoA dehydrogenase activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0004875 complement receptor activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0005025 transforming growth factor beta receptor activity, type I 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0005026 transforming growth factor beta receptor activity, type II 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0005165 neurotrophin receptor binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0005247 voltage-gated chloride channel activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0010853 cyclase activator activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0015269 calcium-activated potassium channel activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0016208 AMP binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0016361 activin receptor activity, type I 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0016362 activin receptor activity, type II 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0017002 activin receptor activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0035259 nuclear glucocorticoid receptor binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0035497 cAMP response element binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0036009 protein-glutamine N-methyltransferase activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0042301 phosphate ion binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0097371 MDM2/MDM4 family protein binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:1990459 transferrin receptor binding 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:1990817 poly(A) RNA polymerase activity 1/1489 12/18639 0.0833333333333333 1.04314976494291 0.63190101634739 0.930921383943995 GO:0016410 N-acyltransferase activity 7/1489 94/18639 0.074468085106383 0.932176385693668 0.632252622459726 0.930921383943995 GO:0042562 hormone binding 7/1489 94/18639 0.074468085106383 0.932176385693668 0.632252622459726 0.930921383943995 GO:0099106 ion channel regulator activity 12/1489 160/18639 0.075 0.938834788448623 0.632960693415502 0.930921383943995 GO:0015485 cholesterol binding 4/1489 54/18639 0.0740740740740741 0.927244235504813 0.6354877314877 0.933205126724154 GO:0030971 receptor tyrosine kinase binding 6/1489 81/18639 0.0740740740740741 0.927244235504813 0.636163707077208 0.933205126724154 GO:0008276 protein methyltransferase activity 7/1489 95/18639 0.0736842105263158 0.922364002686367 0.643397451533989 0.939557528119741 GO:0042287 MHC protein binding 3/1489 41/18639 0.0731707317073171 0.915936378974266 0.646650730076012 0.939557528119741 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1489 27/18639 0.0740740740740741 0.927244235504813 0.647008572051245 0.939557528119741 GO:0005044 scavenger receptor activity 2/1489 27/18639 0.0740740740740741 0.927244235504813 0.647008572051245 0.939557528119741 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/1489 27/18639 0.0740740740740741 0.927244235504813 0.647008572051245 0.939557528119741 GO:0004721 phosphoprotein phosphatase activity 13/1489 175/18639 0.0742857142857143 0.929893504749113 0.648698134487407 0.939557528119741 GO:0008083 growth factor activity 12/1489 162/18639 0.0740740740740741 0.927244235504813 0.6500811028503 0.939557528119741 GO:0016741 transferase activity, transferring one-carbon groups 16/1489 215/18639 0.0744186046511628 0.931556999390882 0.653508052333734 0.939557528119741 GO:0008080 N-acetyltransferase activity 5/1489 69/18639 0.072463768115942 0.907086752124274 0.654611058354452 0.939557528119741 GO:0002161 aminoacyl-tRNA editing activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0004465 lipoprotein lipase activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0004535 poly(A)-specific ribonuclease activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0005172 vascular endothelial growth factor receptor binding 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0009982 pseudouridine synthase activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0031432 titin binding 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0045159 myosin II binding 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0051011 microtubule minus-end binding 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0070123 transforming growth factor beta receptor activity, type III 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0070700 BMP receptor binding 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0097157 pre-mRNA intronic binding 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0140333 glycerophospholipid flippase activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0140852 histone ubiquitin ligase activity 1/1489 13/18639 0.0769230769230769 0.962907475331921 0.661326011604744 0.939557528119741 GO:0043175 RNA polymerase core enzyme binding 3/1489 42/18639 0.0714285714285714 0.89412836995107 0.6629238792569 0.939557528119741 GO:0051879 Hsp90 protein binding 3/1489 42/18639 0.0714285714285714 0.89412836995107 0.6629238792569 0.939557528119741 GO:0046966 nuclear thyroid hormone receptor binding 2/1489 28/18639 0.0714285714285714 0.89412836995107 0.66679982516997 0.94205666103505 GO:0050698 proteoglycan sulfotransferase activity 2/1489 28/18639 0.0714285714285714 0.89412836995107 0.66679982516997 0.94205666103505 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1489 70/18639 0.0714285714285714 0.89412836995107 0.66718601723172 0.94205666103505 GO:0008168 methyltransferase activity 15/1489 204/18639 0.0735294117647059 0.920426263184925 0.669298727402992 0.943861422310204 GO:0008200 ion channel inhibitor activity 3/1489 43/18639 0.0697674418604651 0.873334686928952 0.678645358442569 0.944879528631846 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1489 43/18639 0.0697674418604651 0.873334686928952 0.678645358442569 0.944879528631846 GO:0005416 amino acid:monoatomic cation symporter activity 2/1489 29/18639 0.0689655172413793 0.863296357194136 0.685684219933206 0.944879528631846 GO:0016417 S-acyltransferase activity 2/1489 29/18639 0.0689655172413793 0.863296357194136 0.685684219933206 0.944879528631846 GO:0099604 ligand-gated calcium channel activity 2/1489 29/18639 0.0689655172413793 0.863296357194136 0.685684219933206 0.944879528631846 GO:0004065 arylsulfatase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0004705 JUN kinase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0005313 L-glutamate transmembrane transporter activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0005545 1-phosphatidylinositol binding 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0008174 mRNA methyltransferase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0008392 arachidonate epoxygenase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0008494 translation activator activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0015926 glucosidase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0030983 mismatched DNA binding 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0032454 histone H3K9 demethylase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0034236 protein kinase A catalytic subunit binding 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0071933 Arp2/3 complex binding 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0098599 palmitoyl hydrolase activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0098821 BMP receptor activity 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:1901612 cardiolipin binding 1/1489 14/18639 0.0714285714285714 0.89412836995107 0.688400293185359 0.944879528631846 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 12/1489 167/18639 0.0718562874251497 0.899482432046585 0.690922321019677 0.945785874824519 GO:0005516 calmodulin binding 15/1489 207/18639 0.072463768115942 0.907086752124274 0.691014000699337 0.945785874824519 GO:0016248 channel inhibitor activity 3/1489 44/18639 0.0681818181818182 0.85348617131693 0.69381615819661 0.945785874824519 GO:0004519 endonuclease activity 9/1489 127/18639 0.0708661417322835 0.887087989085313 0.693931546688968 0.945785874824519 GO:0001965 G-protein alpha-subunit binding 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0033612 receptor serine/threonine kinase binding 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0048019 receptor antagonist activity 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0051721 protein phosphatase 2A binding 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0070566 adenylyltransferase activity 2/1489 30/18639 0.0666666666666667 0.834519811954332 0.703680242145525 0.945785874824519 GO:0015459 potassium channel regulator activity 4/1489 59/18639 0.0677966101694915 0.848664215546778 0.703992195175133 0.945785874824519 GO:0045309 protein phosphorylated amino acid binding 4/1489 59/18639 0.0677966101694915 0.848664215546778 0.703992195175133 0.945785874824519 GO:0070888 E-box binding 4/1489 59/18639 0.0677966101694915 0.848664215546778 0.703992195175133 0.945785874824519 GO:0140303 intramembrane lipid transporter activity 3/1489 45/18639 0.0666666666666667 0.834519811954332 0.708439287009581 0.945785874824519 GO:0141110 transporter inhibitor activity 3/1489 45/18639 0.0666666666666667 0.834519811954332 0.708439287009581 0.945785874824519 GO:0004089 carbonate dehydratase activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0005523 tropomyosin binding 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0008242 omega peptidase activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0015116 sulfate transmembrane transporter activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0033130 acetylcholine receptor binding 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0042809 nuclear vitamin D receptor binding 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0050700 CARD domain binding 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0050780 dopamine receptor binding 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0051371 muscle alpha-actinin binding 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0061578 K63-linked deubiquitinase activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0140161 monocarboxylate:sodium symporter activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0140776 protein-containing complex destabilizing activity 1/1489 15/18639 0.0666666666666667 0.834519811954332 0.713311539544929 0.945785874824519 GO:0004197 cysteine-type endopeptidase activity 6/1489 88/18639 0.0681818181818182 0.85348617131693 0.714424273069504 0.946152052507739 GO:0008238 exopeptidase activity 7/1489 102/18639 0.0686274509803922 0.85906451230593 0.715638313353506 0.94665138292727 GO:0015294 solute:monoatomic cation symporter activity 8/1489 116/18639 0.0689655172413793 0.863296357194136 0.717597767340358 0.947288597800089 GO:0008237 metallopeptidase activity 13/1489 184/18639 0.0706521739130435 0.884409583321167 0.717795162081942 0.947288597800089 GO:0005452 solute:inorganic anion antiporter activity 2/1489 31/18639 0.0645161290322581 0.807599818020321 0.720809211571851 0.947947928241585 GO:0008327 methyl-CpG binding 2/1489 31/18639 0.0645161290322581 0.807599818020321 0.720809211571851 0.947947928241585 GO:0047499 calcium-independent phospholipase A2 activity 2/1489 31/18639 0.0645161290322581 0.807599818020321 0.720809211571851 0.947947928241585 GO:0030291 protein serine/threonine kinase inhibitor activity 3/1489 46/18639 0.0652173913043478 0.816378076911846 0.722519550395314 0.949093625432172 GO:0016836 hydro-lyase activity 4/1489 61/18639 0.0655737704918033 0.820839159299343 0.728632466157236 0.950574822183785 GO:0140030 modification-dependent protein binding 12/1489 173/18639 0.069364161849711 0.86828650954786 0.735978165606434 0.950574822183785 GO:0140938 histone H3 methyltransferase activity 3/1489 47/18639 0.0638297872340425 0.799008330594573 0.736063343787777 0.950574822183785 GO:0004707 MAP kinase activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0005149 interleukin-1 receptor binding 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0008296 3'-5'-DNA exonuclease activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0008391 arachidonate monooxygenase activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0015378 sodium:chloride symporter activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0016722 oxidoreductase activity, acting on metal ions 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0055102 lipase inhibitor activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0140327 flippase activity 1/1489 16/18639 0.0625 0.782362323707186 0.736232454365462 0.950574822183785 GO:0015106 bicarbonate transmembrane transporter activity 2/1489 32/18639 0.0625 0.782362323707186 0.737094711808293 0.950574822183785 GO:0047498 calcium-dependent phospholipase A2 activity 2/1489 32/18639 0.0625 0.782362323707186 0.737094711808293 0.950574822183785 GO:0051059 NF-kappaB binding 2/1489 32/18639 0.0625 0.782362323707186 0.737094711808293 0.950574822183785 GO:0106310 protein serine kinase activity 26/1489 361/18639 0.07202216066482 0.901558799618253 0.738677106599285 0.951530532532792 GO:0003724 RNA helicase activity 5/1489 77/18639 0.0649350649350649 0.812843972682791 0.746599941353335 0.960642245359069 GO:0008484 sulfuric ester hydrolase activity 1/1489 17/18639 0.0588235294117647 0.73634101054794 0.757321960645322 0.970023938267111 GO:0030548 acetylcholine receptor regulator activity 1/1489 17/18639 0.0588235294117647 0.73634101054794 0.757321960645322 0.970023938267111 GO:0031489 myosin V binding 1/1489 17/18639 0.0588235294117647 0.73634101054794 0.757321960645322 0.970023938267111 GO:0038191 neuropilin binding 1/1489 17/18639 0.0588235294117647 0.73634101054794 0.757321960645322 0.970023938267111 GO:0019902 phosphatase binding 13/1489 190/18639 0.068421052631579 0.856480859637341 0.758791227832457 0.970806423844468 GO:0008186 ATP-dependent activity, acting on RNA 5/1489 79/18639 0.0632911392405063 0.792265644260442 0.766511241920041 0.977459790026607 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1489 34/18639 0.0588235294117647 0.73634101054794 0.767238039805159 0.977459790026607 GO:0051427 hormone receptor binding 2/1489 34/18639 0.0588235294117647 0.73634101054794 0.767238039805159 0.977459790026607 GO:0016791 phosphatase activity 19/1489 273/18639 0.0695970695970696 0.871202001490786 0.767448535405506 0.977459790026607 GO:0005319 lipid transporter activity 12/1489 178/18639 0.0674157303370786 0.843896439054942 0.770072901053797 0.977663080874599 GO:0120013 lipid transfer activity 4/1489 65/18639 0.0615384615384615 0.770325980265537 0.773239064538245 0.977663080874599 GO:0015605 organophosphate ester transmembrane transporter activity 3/1489 50/18639 0.06 0.751067830758898 0.773559739362281 0.977663080874599 GO:0048020 CCR chemokine receptor binding 3/1489 50/18639 0.06 0.751067830758898 0.773559739362281 0.977663080874599 GO:0008308 voltage-gated monoatomic anion channel activity 1/1489 18/18639 0.0555555555555556 0.69543317662861 0.77672629963142 0.977663080874599 GO:0015373 monoatomic anion:sodium symporter activity 1/1489 18/18639 0.0555555555555556 0.69543317662861 0.77672629963142 0.977663080874599 GO:0017128 phospholipid scramblase activity 1/1489 18/18639 0.0555555555555556 0.69543317662861 0.77672629963142 0.977663080874599 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1489 18/18639 0.0555555555555556 0.69543317662861 0.77672629963142 0.977663080874599 GO:0070064 proline-rich region binding 1/1489 18/18639 0.0555555555555556 0.69543317662861 0.77672629963142 0.977663080874599 GO:0099602 neurotransmitter receptor regulator activity 1/1489 18/18639 0.0555555555555556 0.69543317662861 0.77672629963142 0.977663080874599 GO:0030695 GTPase regulator activity 35/1489 489/18639 0.0715746421267894 0.895956853325203 0.777116807874681 0.977663080874599 GO:0060589 nucleoside-triphosphatase regulator activity 35/1489 490/18639 0.0714285714285714 0.89412836995107 0.781035588943445 0.978384132818854 GO:0004623 phospholipase A2 activity 2/1489 35/18639 0.0571428571428571 0.715302695960856 0.781150196229377 0.978384132818854 GO:0005343 organic acid:sodium symporter activity 2/1489 35/18639 0.0571428571428571 0.715302695960856 0.781150196229377 0.978384132818854 GO:0034061 DNA polymerase activity 2/1489 35/18639 0.0571428571428571 0.715302695960856 0.781150196229377 0.978384132818854 GO:0042054 histone methyltransferase activity 4/1489 67/18639 0.0597014925373134 0.747331174884476 0.793274443443757 0.985383802298874 GO:0004033 aldo-keto reductase (NADPH) activity 2/1489 36/18639 0.0555555555555556 0.69543317662861 0.794326842859713 0.985383802298874 GO:0016409 palmitoyltransferase activity 2/1489 36/18639 0.0555555555555556 0.69543317662861 0.794326842859713 0.985383802298874 GO:0045505 dynein intermediate chain binding 2/1489 36/18639 0.0555555555555556 0.69543317662861 0.794326842859713 0.985383802298874 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1489 19/18639 0.0526315789473684 0.658831430490262 0.794580042172036 0.985383802298874 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1489 19/18639 0.0526315789473684 0.658831430490262 0.794580042172036 0.985383802298874 GO:0015245 fatty acid transmembrane transporter activity 1/1489 19/18639 0.0526315789473684 0.658831430490262 0.794580042172036 0.985383802298874 GO:0034987 immunoglobulin receptor binding 1/1489 19/18639 0.0526315789473684 0.658831430490262 0.794580042172036 0.985383802298874 GO:0042834 peptidoglycan binding 1/1489 19/18639 0.0526315789473684 0.658831430490262 0.794580042172036 0.985383802298874 GO:0032934 sterol binding 4/1489 68/18639 0.0588235294117647 0.73634101054794 0.802745583439172 0.994419775322786 GO:0005544 calcium-dependent phospholipid binding 3/1489 53/18639 0.0566037735849057 0.708554557319716 0.806572751210092 0.995078490487246 GO:0008146 sulfotransferase activity 3/1489 53/18639 0.0566037735849057 0.708554557319716 0.806572751210092 0.995078490487246 GO:0034212 protein N-acetyltransferase activity 3/1489 53/18639 0.0566037735849057 0.708554557319716 0.806572751210092 0.995078490487246 GO:0022829 wide pore channel activity 2/1489 37/18639 0.0540540540540541 0.676637685368377 0.806796618723965 0.995078490487246 GO:0010851 cyclase regulator activity 1/1489 20/18639 0.05 0.625889858965749 0.811007019465583 0.99809460175797 GO:0140664 ATP-dependent DNA damage sensor activity 1/1489 20/18639 0.05 0.625889858965749 0.811007019465583 0.99809460175797 GO:1901981 phosphatidylinositol phosphate binding 12/1489 185/18639 0.0648648648648649 0.811965222442052 0.812471997694187 0.998810684121876 GO:0001664 G protein-coupled receptor binding 20/1489 297/18639 0.0673400673400673 0.842949305004376 0.817952011989283 0.999999967570588 GO:0008373 sialyltransferase activity 1/1489 21/18639 0.0476190476190476 0.59608557996738 0.826121179625406 0.999999967570588 GO:0009975 cyclase activity 1/1489 21/18639 0.0476190476190476 0.59608557996738 0.826121179625406 0.999999967570588 GO:0051428 peptide hormone receptor binding 1/1489 21/18639 0.0476190476190476 0.59608557996738 0.826121179625406 0.999999967570588 GO:1904047 S-adenosyl-L-methionine binding 1/1489 21/18639 0.0476190476190476 0.59608557996738 0.826121179625406 0.999999967570588 GO:0015291 secondary active transmembrane transporter activity 19/1489 287/18639 0.0662020905923345 0.828704342881479 0.834194943210781 0.999999967570588 GO:0170055 lipid transmembrane transporter activity 3/1489 56/18639 0.0535714285714286 0.670596277463302 0.835432100174497 0.999999967570588 GO:0008649 rRNA methyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0008970 phospholipase A1 activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0015377 chloride:monoatomic cation symporter activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0016881 acid-amino acid ligase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0032931 histone H3K56 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0043992 histone H3K9 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0043993 histone H3K18 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0043994 histone H3K23 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0043999 histone H2AK5 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0044012 histone H2AK9 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0044014 histone H2BK5 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0044015 histone H2BK12 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0044016 histone H3K4 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0044017 histone H3K27 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0044018 histone H3K36 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0046972 histone H4K16 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0061133 endopeptidase activator activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0140908 histone H3K122 acetyltransferase activity 1/1489 22/18639 0.0454545454545455 0.568990780877954 0.840027375969684 0.999999967570588 GO:0032451 demethylase activity 2/1489 40/18639 0.05 0.625889858965749 0.840251745546348 0.999999967570588 GO:0016651 oxidoreductase activity, acting on NAD(P)H 5/1489 88/18639 0.0568181818181818 0.711238476097442 0.841576449348613 0.999999967570588 GO:0004521 RNA endonuclease activity 4/1489 73/18639 0.0547945205479452 0.685906694756985 0.844926793558021 0.999999967570588 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 5/1489 89/18639 0.0561797752808989 0.703247032545785 0.848539577355303 0.999999967570588 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 5/1489 89/18639 0.0561797752808989 0.703247032545785 0.848539577355303 0.999999967570588 GO:0001727 lipid kinase activity 2/1489 41/18639 0.0487804878048781 0.610624252649511 0.850180002749955 0.999999967570588 GO:0000295 adenine nucleotide transmembrane transporter activity 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:0016849 phosphorus-oxygen lyase activity 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:0031681 G-protein beta-subunit binding 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:0044013 histone H2B acetyltransferase activity 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:0140102 catalytic activity, acting on a rRNA 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1489 23/18639 0.0434782608695652 0.544252051274564 0.85282209247509 0.999999967570588 GO:0015297 antiporter activity 8/1489 135/18639 0.0592592592592593 0.74179538840385 0.854141663335903 0.999999967570588 GO:0140793 histone H2AXY142 phosphatase activity 5/1489 90/18639 0.0555555555555556 0.69543317662861 0.855247117604572 0.999999967570588 GO:0019894 kinesin binding 2/1489 42/18639 0.0476190476190476 0.59608557996738 0.859542808924608 0.999999967570588 GO:0000149 SNARE binding 6/1489 106/18639 0.0566037735849057 0.708554557319716 0.859556155675157 0.999999967570588 GO:0004497 monooxygenase activity 6/1489 106/18639 0.0566037735849057 0.708554557319716 0.859556155675157 0.999999967570588 GO:0004879 nuclear receptor activity 3/1489 59/18639 0.0508474576271186 0.636498161660084 0.860500676965132 0.999999967570588 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 7/1489 122/18639 0.0573770491803279 0.718234264386925 0.864559663723578 0.999999967570588 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0004806 triacylglycerol lipase activity 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0030552 cAMP binding 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0043998 histone H2A acetyltransferase activity 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0070300 phosphatidic acid binding 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0070840 dynein complex binding 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0140612 DNA damage sensor activity 1/1489 24/18639 0.0416666666666667 0.521574882471457 0.864594111399917 0.999999967570588 GO:0098531 ligand-modulated transcription factor activity 3/1489 60/18639 0.05 0.625889858965749 0.868079159735848 0.999999967570588 GO:0140767 enzyme-substrate adaptor activity 8/1489 139/18639 0.0575539568345324 0.720448758521725 0.874788293198303 0.999999967570588 GO:0019905 syntaxin binding 3/1489 61/18639 0.0491803278688525 0.615629369474507 0.875291919748535 0.999999967570588 GO:0003707 nuclear steroid receptor activity 1/1489 25/18639 0.04 0.500711887172599 0.875425127683856 0.999999967570588 GO:0005251 delayed rectifier potassium channel activity 1/1489 25/18639 0.04 0.500711887172599 0.875425127683856 0.999999967570588 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1489 25/18639 0.04 0.500711887172599 0.875425127683856 0.999999967570588 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1489 25/18639 0.04 0.500711887172599 0.875425127683856 0.999999967570588 GO:0120020 cholesterol transfer activity 1/1489 25/18639 0.04 0.500711887172599 0.875425127683856 0.999999967570588 GO:0004620 phospholipase activity 6/1489 109/18639 0.055045871559633 0.689053055742109 0.876549763097492 0.999999967570588 GO:0001223 transcription coactivator binding 2/1489 44/18639 0.0454545454545455 0.568990780877954 0.876679023211551 0.999999967570588 GO:0016790 thiolester hydrolase activity 2/1489 44/18639 0.0454545454545455 0.568990780877954 0.876679023211551 0.999999967570588 GO:0051539 4 iron, 4 sulfur cluster binding 2/1489 45/18639 0.0444444444444444 0.556346541302888 0.884504127220945 0.999999967570588 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:0005227 calcium-activated cation channel activity 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:0008198 ferrous iron binding 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:0015216 purine nucleotide transmembrane transporter activity 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:0030507 spectrin binding 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:0043548 phosphatidylinositol 3-kinase binding 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:0097602 cullin family protein binding 1/1489 26/18639 0.0384615384615385 0.481453737665961 0.885390314364781 0.999999967570588 GO:1902936 phosphatidylinositol bisphosphate binding 6/1489 111/18639 0.0540540540540541 0.676637685368377 0.886893157013973 0.999999967570588 GO:0008234 cysteine-type peptidase activity 11/1489 187/18639 0.0588235294117647 0.73634101054794 0.889739097191738 0.999999967570588 GO:0004896 cytokine receptor activity 5/1489 96/18639 0.0520833333333333 0.651968603089322 0.890465916507399 0.999999967570588 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/1489 46/18639 0.0434782608695652 0.544252051274564 0.891867062531201 0.999999967570588 GO:0005104 fibroblast growth factor receptor binding 1/1489 27/18639 0.037037037037037 0.463622117752406 0.894558842915302 0.999999967570588 GO:0015252 proton channel activity 1/1489 27/18639 0.037037037037037 0.463622117752406 0.894558842915302 0.999999967570588 GO:0035255 ionotropic glutamate receptor binding 1/1489 27/18639 0.037037037037037 0.463622117752406 0.894558842915302 0.999999967570588 GO:0001784 phosphotyrosine residue binding 2/1489 47/18639 0.0425531914893617 0.532672220396382 0.898791672253131 0.999999967570588 GO:0061733 protein-lysine-acetyltransferase activity 2/1489 47/18639 0.0425531914893617 0.532672220396382 0.898791672253131 0.999999967570588 GO:0004725 protein tyrosine phosphatase activity 5/1489 98/18639 0.0510204081632653 0.638663121393621 0.900440369697806 0.999999967570588 GO:0008170 N-methyltransferase activity 5/1489 98/18639 0.0510204081632653 0.638663121393621 0.900440369697806 0.999999967570588 GO:0042578 phosphoric ester hydrolase activity 23/1489 363/18639 0.0633608815426997 0.793138664254117 0.901453580002214 0.999999967570588 GO:0036408 histone H3K14 acetyltransferase activity 1/1489 28/18639 0.0357142857142857 0.447064184975535 0.902994362091055 0.999999967570588 GO:0051019 mitogen-activated protein kinase binding 1/1489 28/18639 0.0357142857142857 0.447064184975535 0.902994362091055 0.999999967570588 GO:0051393 alpha-actinin binding 1/1489 28/18639 0.0357142857142857 0.447064184975535 0.902994362091055 0.999999967570588 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1489 28/18639 0.0357142857142857 0.447064184975535 0.902994362091055 0.999999967570588 GO:0141052 histone H3 demethylase activity 1/1489 28/18639 0.0357142857142857 0.447064184975535 0.902994362091055 0.999999967570588 GO:0008188 neuropeptide receptor activity 2/1489 48/18639 0.0416666666666667 0.521574882471457 0.905300942388953 0.999999967570588 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1489 48/18639 0.0416666666666667 0.521574882471457 0.905300942388953 0.999999967570588 GO:0030165 PDZ domain binding 4/1489 83/18639 0.0481927710843374 0.60326733394289 0.906754525451294 0.999999967570588 GO:0004181 metallocarboxypeptidase activity 1/1489 29/18639 0.0344827586206897 0.431648178597068 0.910755438596693 0.999999967570588 GO:0004629 phospholipase C activity 1/1489 29/18639 0.0344827586206897 0.431648178597068 0.910755438596693 0.999999967570588 GO:0010484 histone H3 acetyltransferase activity 1/1489 29/18639 0.0344827586206897 0.431648178597068 0.910755438596693 0.999999967570588 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/1489 29/18639 0.0344827586206897 0.431648178597068 0.910755438596693 0.999999967570588 GO:0016763 pentosyltransferase activity 2/1489 49/18639 0.0408163265306122 0.510930497114897 0.911416986536772 0.999999967570588 GO:0035254 glutamate receptor binding 2/1489 49/18639 0.0408163265306122 0.510930497114897 0.911416986536772 0.999999967570588 GO:0015215 nucleotide transmembrane transporter activity 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0022839 monoatomic ion-gated channel activity 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0031624 ubiquitin conjugating enzyme binding 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0032452 histone demethylase activity 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0043995 histone H4K5 acetyltransferase activity 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0043996 histone H4K8 acetyltransferase activity 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0043997 histone H4K12 acetyltransferase activity 1/1489 30/18639 0.0333333333333333 0.417259905977166 0.91789596261225 0.999999967570588 GO:0035091 phosphatidylinositol binding 17/1489 284/18639 0.0598591549295775 0.749304760733643 0.918663336608327 0.999999967570588 GO:0016279 protein-lysine N-methyltransferase activity 3/1489 69/18639 0.0434782608695652 0.544252051274564 0.92143473100524 0.999999967570588 GO:0005164 tumor necrosis factor receptor binding 1/1489 31/18639 0.032258064516129 0.403799909010161 0.924465520980263 0.999999967570588 GO:0005184 neuropeptide hormone activity 1/1489 31/18639 0.032258064516129 0.403799909010161 0.924465520980263 0.999999967570588 GO:0016878 acid-thiol ligase activity 1/1489 31/18639 0.032258064516129 0.403799909010161 0.924465520980263 0.999999967570588 GO:0140457 protein demethylase activity 1/1489 31/18639 0.032258064516129 0.403799909010161 0.924465520980263 0.999999967570588 GO:0008081 phosphoric diester hydrolase activity 4/1489 87/18639 0.0459770114942529 0.575530904796091 0.92460775454281 0.999999967570588 GO:0016278 lysine N-methyltransferase activity 3/1489 70/18639 0.0428571428571429 0.536477021970642 0.925948386039378 0.999999967570588 GO:0120015 sterol transfer activity 1/1489 32/18639 0.03125 0.391181161853593 0.930509740630972 0.999999967570588 GO:0160041 neuropeptide activity 1/1489 32/18639 0.03125 0.391181161853593 0.930509740630972 0.999999967570588 GO:0008528 G protein-coupled peptide receptor activity 6/1489 122/18639 0.0491803278688525 0.615629369474507 0.931508715116604 0.999999967570588 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1489 53/18639 0.0377358490566038 0.47236970487981 0.93236040802248 0.999999967570588 GO:0001216 DNA-binding transcription activator activity 31/1489 491/18639 0.0631364562118126 0.790329353480172 0.933433719909952 0.999999967570588 GO:0140311 protein sequestering activity 1/1489 33/18639 0.0303030303030303 0.379327187251969 0.93607060461767 0.999999967570588 GO:0005543 phospholipid binding 31/1489 497/18639 0.062374245472837 0.780788154041779 0.942825080227986 0.999999967570588 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 30/1489 484/18639 0.0619834710743802 0.775896519379027 0.944545644151333 0.999999967570588 GO:0010485 histone H4 acetyltransferase activity 1/1489 35/18639 0.0285714285714286 0.357651347980428 0.945893700201673 0.999999967570588 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/1489 57/18639 0.0350877192982456 0.439220953660175 0.948554564065007 0.999999967570588 GO:0001653 peptide receptor activity 6/1489 128/18639 0.046875 0.58677174278039 0.948596322752489 0.999999967570588 GO:0005484 SNAP receptor activity 1/1489 36/18639 0.0277777777777778 0.347716588314305 0.950224181840015 0.999999967570588 GO:0016298 lipase activity 6/1489 130/18639 0.0461538461538462 0.577744485199153 0.953376394554687 0.999999967570588 GO:0019213 deacetylase activity 1/1489 37/18639 0.027027027027027 0.338318842684189 0.95420828081546 0.999999967570588 GO:0030280 structural constituent of skin epidermis 1/1489 37/18639 0.027027027027027 0.338318842684189 0.95420828081546 0.999999967570588 GO:0042805 actinin binding 1/1489 37/18639 0.027027027027027 0.338318842684189 0.95420828081546 0.999999967570588 GO:0001786 phosphatidylserine binding 2/1489 59/18639 0.0338983050847458 0.424332107773389 0.955193487913288 0.999999967570588 GO:0031593 polyubiquitin modification-dependent protein binding 2/1489 59/18639 0.0338983050847458 0.424332107773389 0.955193487913288 0.999999967570588 GO:0015370 solute:sodium symporter activity 3/1489 79/18639 0.0379746835443038 0.475359386556265 0.957054087942391 0.999999967570588 GO:0005126 cytokine receptor binding 15/1489 275/18639 0.0545454545454545 0.682788937053544 0.959167955197184 0.999999967570588 GO:0035402 histone H3T11 kinase activity 13/1489 247/18639 0.0526315789473684 0.658831430490262 0.962944377139532 0.999999967570588 GO:0035403 histone H3T6 kinase activity 13/1489 247/18639 0.0526315789473684 0.658831430490262 0.962944377139532 0.999999967570588 GO:0071855 neuropeptide receptor binding 1/1489 40/18639 0.025 0.312944929482874 0.964348288375573 0.999999967570588 GO:0016779 nucleotidyltransferase activity 6/1489 136/18639 0.0441176470588235 0.552255757910955 0.965401549748745 0.999999967570588 GO:0004812 aminoacyl-tRNA ligase activity 1/1489 41/18639 0.024390243902439 0.305312126324756 0.967202495516214 0.999999967570588 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/1489 41/18639 0.024390243902439 0.305312126324756 0.967202495516214 0.999999967570588 GO:0004402 histone acetyltransferase activity 1/1489 42/18639 0.0238095238095238 0.29804278998369 0.969828341530643 0.999999967570588 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/1489 86/18639 0.0348837209302326 0.436667343464476 0.972267808501219 0.999999967570588 GO:0140223 general transcription initiation factor activity 2/1489 68/18639 0.0294117647058824 0.36817050527397 0.976168456694784 0.999999967570588 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 12/1489 243/18639 0.0493827160493827 0.618162823669875 0.976707660611819 0.999999967570588 GO:0004843 cysteine-type deubiquitinase activity 4/1489 108/18639 0.037037037037037 0.463622117752406 0.976947686375482 0.999999967570588 GO:0019783 ubiquitin-like protein peptidase activity 5/1489 127/18639 0.0393700787401575 0.492826660602952 0.977874273774035 0.999999967570588 GO:0004180 carboxypeptidase activity 1/1489 46/18639 0.0217391304347826 0.272126025637282 0.978392108606364 0.999999967570588 GO:0004676 3-phosphoinositide-dependent protein kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0004711 ribosomal protein S6 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0035175 histone H3S10 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0035979 histone H2AXS139 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0044022 histone H3S28 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0044023 histone H4S1 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0044024 histone H2AS1 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0044025 histone H2BS14 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0072354 histone H3T3 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0072371 histone H2AS121 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0072518 Rho-dependent protein serine/threonine kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0140823 histone H2BS36 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0140855 histone H3S57 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0140995 histone H2A kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0140997 histone H4 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0140998 histone H2B kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:1990244 histone H2AT120 kinase activity 12/1489 245/18639 0.0489795918367347 0.613116596537876 0.978558914777513 0.999999967570588 GO:0004677 DNA-dependent protein kinase activity 12/1489 246/18639 0.0487804878048781 0.610624252649511 0.979433492455469 0.999999967570588 GO:0140857 histone H3T45 kinase activity 12/1489 246/18639 0.0487804878048781 0.610624252649511 0.979433492455469 0.999999967570588 GO:0015085 calcium ion transmembrane transporter activity 6/1489 147/18639 0.0408163265306122 0.510930497114897 0.98036972341383 0.999999967570588 GO:0140098 catalytic activity, acting on RNA 21/1489 387/18639 0.0542635658914729 0.679260312055851 0.980428134895287 0.999999967570588 GO:0015103 inorganic anion transmembrane transporter activity 7/1489 165/18639 0.0424242424242424 0.531058062152757 0.980961648130923 0.999999967570588 GO:0004679 AMP-activated protein kinase activity 12/1489 248/18639 0.0483870967741935 0.605699863515241 0.981085963172528 0.999999967570588 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/1489 130/18639 0.0384615384615385 0.481453737665961 0.981267220027994 0.999999967570588 GO:0005125 cytokine activity 11/1489 234/18639 0.047008547008547 0.588443457147285 0.98277679940674 0.999999967570588 GO:0032813 tumor necrosis factor receptor superfamily binding 1/1489 50/18639 0.02 0.2503559435863 0.984526339629596 0.999999967570588 GO:0101005 deubiquitinase activity 4/1489 115/18639 0.0347826086956522 0.435401641019651 0.984802485982275 0.999999967570588 GO:0016597 amino acid binding 1/1489 51/18639 0.0196078431372549 0.24544700351598 0.985765797389106 0.999999967570588 GO:0061630 ubiquitin protein ligase activity 18/1489 353/18639 0.0509915014164306 0.63830127259963 0.987339100799712 0.999999967570588 GO:0140375 immune receptor activity 6/1489 156/18639 0.0384615384615385 0.481453737665961 0.987865332448176 0.999999967570588 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/1489 53/18639 0.0188679245283019 0.236184852439905 0.987954988870159 0.999999967570588 GO:0140101 catalytic activity, acting on a tRNA 5/1489 139/18639 0.0359712230215827 0.450280474076078 0.988746144457342 0.999999967570588 GO:0061659 ubiquitin-like protein ligase activity 19/1489 372/18639 0.0510752688172043 0.639349855932754 0.988861343918736 0.999999967570588 GO:0005085 guanyl-nucleotide exchange factor activity 10/1489 230/18639 0.0434782608695652 0.544252051274564 0.990270344387495 0.999999967570588 GO:0005254 chloride channel activity 2/1489 83/18639 0.0240963855421687 0.301633666971445 0.991910663690469 0.999999967570588 GO:0008509 monoatomic anion transmembrane transporter activity 5/1489 149/18639 0.0335570469798658 0.420060308030704 0.993714958969745 0.999999967570588 GO:0005262 calcium channel activity 4/1489 131/18639 0.0305343511450382 0.382222814635572 0.994323631402132 0.999999967570588 GO:0003823 antigen binding 6/1489 174/18639 0.0344827586206897 0.431648178597068 0.995548374896871 0.999999967570588 GO:0160215 deacylase activity 1/1489 65/18639 0.0153846153846154 0.192581495066384 0.995579406491168 0.999999967570588 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/1489 67/18639 0.0149253731343284 0.186832793721119 0.996259775871344 0.999999967570588 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 11/1489 268/18639 0.041044776119403 0.513790182733077 0.996412597252382 0.999999967570588 GO:0004842 ubiquitin-protein transferase activity 22/1489 449/18639 0.0489977728285078 0.613344182505411 0.996429051142116 0.999999967570588 GO:0015108 chloride transmembrane transporter activity 3/1489 121/18639 0.0247933884297521 0.310358607751611 0.9972685033718 0.999999967570588 GO:0030527 structural constituent of chromatin 2/1489 98/18639 0.0204081632653061 0.255465248557448 0.997326141627143 0.999999967570588 GO:0001217 DNA-binding transcription repressor activity 11/1489 278/18639 0.039568345323741 0.495308521483686 0.997803847927555 0.999999967570588 GO:0019787 ubiquitin-like protein transferase activity 23/1489 479/18639 0.0480167014613779 0.601063330113245 0.99794216188301 0.999999967570588 GO:0005253 monoatomic anion channel activity 2/1489 103/18639 0.0194174757281553 0.24306402289932 0.998159893421745 0.999999967570588 GO:0016755 aminoacyltransferase activity 23/1489 496/18639 0.0463709677419355 0.580462369202106 0.998961922664687 0.999999967570588 GO:0099094 ligand-gated monoatomic cation channel activity 3/1489 136/18639 0.0220588235294118 0.276127878955477 0.999036937053171 0.999999967570588 GO:0015081 sodium ion transmembrane transporter activity 4/1489 164/18639 0.024390243902439 0.305312126324756 0.999334501399549 0.999999967570588 GO:0005267 potassium channel activity 2/1489 124/18639 0.0161290322580645 0.20189995450508 0.999624735629849 0.999999967570588 GO:0005249 voltage-gated potassium channel activity 1/1489 98/18639 0.0102040816326531 0.127732624278724 0.999720219010079 0.999999967570588 GO:0046873 metal ion transmembrane transporter activity 18/1489 450/18639 0.04 0.500711887172599 0.999804331462177 0.999999967570588 GO:0015079 potassium ion transmembrane transporter activity 3/1489 160/18639 0.01875 0.234708697112156 0.999826043993584 0.999999967570588 GO:0022834 ligand-gated channel activity 4/1489 188/18639 0.0212765957446809 0.266336110198191 0.99986968990449 0.999999967570588 GO:0015276 ligand-gated monoatomic ion channel activity 3/1489 186/18639 0.0161290322580645 0.20189995450508 0.999974005352262 0.999999967570588 GO:0005244 voltage-gated monoatomic ion channel activity 2/1489 173/18639 0.0115606936416185 0.144714418257977 0.99999162348022 0.999999967570588 GO:0022832 voltage-gated channel activity 2/1489 175/18639 0.0114285714285714 0.143060539192171 0.999992842345071 0.999999967570588 GO:0022843 voltage-gated monoatomic cation channel activity 1/1489 143/18639 0.00699300699300699 0.0875370432119928 0.999993562939992 0.999999967570588 GO:0045182 translation regulator activity 9/1489 356/18639 0.0252808988764045 0.316461164645603 0.999997068403419 0.999999967570588 GO:0022836 gated channel activity 7/1489 318/18639 0.0220125786163522 0.275548994513223 0.999997948372824 0.999999967570588 GO:0005261 monoatomic cation channel activity 8/1489 341/18639 0.0234604105571848 0.293672661098299 0.999998060476133 0.999999967570588 GO:0030371 translation repressor activity 5/1489 329/18639 0.0151975683890578 0.190240078712994 0.999999966697124 0.999999967570588 GO:0005216 monoatomic ion channel activity 10/1489 448/18639 0.0223214285714286 0.279415115609709 0.999999967570588 0.999999967570588