category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	94/629	222/9376	6.31163436886807	RPL29/RPL6/RPS3A/RPS6/RPS4X/RPS18/RPL37A/RPL18A/RPL19/RPL36/RPS15/RPL7A/RPL11/RPL39/RPS19/RPS5/RPS7/RPL14/RPLP0/RPS2/RPL28/RPSA/RPL8/RPL22/RPL13/RPL37/RPS9/RPS27/RPL32/RPL41/RPL35/RPS27A/RPL3/RPL21/RPL27A/RPS24/RPL5/RPS13/RPL35A/RPLP1/RPS23/RPL10/RPS3/RPL4/RPL13A/RPL23A/RPS16/RPL18/RPS29/RPS20/RPS12/RPL30/RPS8/RPL12/RPL15/RPL9/RPLP2/RPS28/RPL24/RPS11/RPS25/RPL26/RPS14/RPL23/RPL7/RPL38/RPL10A/UBA52/RPS10/RPL31/RPS15A/MRPS15/RPL34/RPL27/RPS21/MRPL11/FAU/RPL22L1/RPL36A/MRPL51/MRPL4/MRPL23/MRPS21/RPL36AL/RPL17/MRPL41/MRPL37/MRPS33/MRPL40/MRPS6/MRPS12/MRPL16/MRPS25/MRPS27	21.4773454807282
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	80/629	238/9376	5.01048750183698	RPL29/RPL6/RPS3A/RPS6/RPS4X/RPS18/RPL37A/RPL18A/RPL19/RPL36/RPS15/RPL7A/RPL11/RPL39/RPS19/RPS5/RPS7/RPL14/RPLP0/RPS2/RPL28/RPSA/RPL8/RPL22/RPL13/RPL37/RPS9/RPS27/RPL32/RPL41/RPL35/RPS27A/RPL3/RPL21/RPL27A/RPS24/RPL5/RPS13/RPL35A/RPLP1/RPS23/RPL10/RPS3/RPL4/RPL13A/RPL23A/RPS16/RPL18/RPS29/RPS20/RPS12/RPL30/RPS8/RPL12/RPL15/RPL9/RPLP2/RPS28/RPL24/RPS11/RPS25/RPL26/RPS14/RPL23/RPL7/RPL38/RPL10A/UBA52/RPS10/RPL31/RPS15A/RPL34/RPL27/RPS21/FAU/RPL22L1/RPL36A/RPL36AL/RPL17/PRKCA	16.8051141419027
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/629	205/9376	3.70837178642057	UQCRH/NDUFA4/MMP2/MT-CO3/COL1A1/MT-CO2/SLC25A6/GAPDH/COL3A1/MT-CO1/MT-CYB/PARP1/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/SLC2A1/COX8A/COX6C/MT-ND1/COX5B/NDUFS5/MPC2/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/PDK3/COL1A2/SLC25A5/NDUFV3/MT-ND6/NDUFB2/PPP1CC/PRKCA/MT-ATP6/PPIF/REN/NDUFV2/NDUFS7/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB	10.5137649249589
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	41/629	158/9376	3.86806463947194	CCNE1/PTTG1/CCNB1/CDC20/CCNA2/CCNB2/ANAPC11/CDK1/AURKB/MAD2L1/CDKN1C/CDC6/E2F5/CDCA5/CCND3/PLK1/CDT1/E2F2/ORC6/TICRR/CDC25C/SMC1A/TFDP1/TRIP13/CDC25A/BUB1/NDC80/ESCO2/CDC45/DBF4/ABL1/TTK/CDK4/CHEK1/FBXO5/MCM7/E2F1/BUB1B/PKMYT1/PCNA/CDC14B	9.7494591588731
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	38/629	138/9376	4.10460588465704	UQCRH/NDUFA4/MT-CO3/MT-CO2/MT-CO1/MT-CYB/NDUFC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/COX6C/MT-ND1/COX5B/NDUFS5/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/NDUFV3/MT-ND6/NDUFB2/MT-ATP6/ATP6V0A4/NDUFV2/CYCS/NDUFS7/NDUFB4/PPA1/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB	9.85231839180391
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	52/629	268/9376	2.89224782288874	UQCRH/RPS27A/NDUFA4/MT-CO3/TUBA1B/GNAS/MT-CO2/SLC25A6/TUBB/UBA52/MT-CO1/TUBA1C/CALM3/HSPA5/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/TXN2/COX8A/COX6C/MT-ND1/ADCY5/COX5B/NDUFS5/PSMA7/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/SLC25A5/NDUFV3/MT-ND6/NDUFB2/MT-ATP6/PPIF/NDUFV2/PARK7/CYCS/NDUFS7/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB	8.4278209022399
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	47/629	235/9376	2.981240063593	RPS6/UQCRH/NDUFA4/MT-CO3/GNAS/MT-CO2/MT-CO1/MT-CYB/NDUFC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/COX6C/MT-ND1/ADCY5/COX5B/NDUFS5/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/ACTG1/UQCRFS1/COX20/NDUFV3/MT-ND6/NDUFB2/GRB2/COA4/MT-ATP6/FGFR1/NDUFV2/NDUFAF2/NDUFS7/NDUFB4/SMARCA2/MT-ND5/NDUFA1/NDUFA2/PPARG/NDUFB9/UQCRB/CPT1C	8.24813149066238
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	45/629	227/9376	2.95497363131465	UQCRH/NDUFA4/MT-CO3/MT-CO2/SLC25A6/MT-CO1/GSTA4/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/COX6C/MT-ND1/MGST1/COX5B/NDUFS5/MGST3/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/SLC25A5/NDUFV3/MT-ND6/NDUFB2/GRB2/MT-ATP6/PPIF/NDUFV2/ACP1/NDUFS7/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB/ABL1	7.99555134383537
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	53/629	308/9376	2.56502797679268	UQCRH/NDUFA4/GPX3/MT-CO3/SLC1A2/TUBA1B/MT-CO2/SLC25A6/TUBB/MT-CO1/TUBA1C/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/POLR2L/COX6C/MT-ND1/COX5B/NDUFS5/PSMA7/COX8C/NDUFB11/MT-ND4/TAF4B/NDUFB1/CYC1/UQCRFS1/TFAM/SLC25A5/NDUFV3/MT-ND6/NDUFB2/MT-ATP6/PPIF/POLR2I/NDUFV2/CYCS/NDUFS7/NDUFB4/POLR2H/MT-ND5/NDUFA1/NDUFA2/PPARG/NDUFB9/POLR2F/UQCRB	7.48898749969084
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/629	157/9376	3.13315038530475	UQCRH/NDUFA4/LEP/MT-CO3/MT-CO2/MT-CO1/MT-CYB/NDUFC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/COX6C/COX5B/NDUFS5/COX8C/NDUFB11/NDUFB1/CYC1/UQCRFS1/NDUFV3/NDUFB2/NDUFV2/CYCS/NDUFS7/NDUFB4/NDUFA1/NDUFA2/PPARG/NDUFB9/UQCRB	7.22787761463382
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	46/629	275/9376	2.4934007804596	UQCRH/NDUFA4/MT-CO3/TUBA1B/MT-CO2/SLC25A6/TUBB/MT-CO1/TUBA1C/HSPA5/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/CAV1/COX8A/COX6C/MT-ND1/COX5B/NDUFS5/PSMA7/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/SLC25A5/NDUFV3/MT-ND6/NDUFB2/MT-ATP6/PPIF/NDUFV2/CYCS/NDUFS7/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB	6.74030519347047
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	54/629	368/9376	2.18732287274487	UQCRH/NDUFA4/GPX3/MT-CO3/SLC1A2/TUBA1B/HNRNPA1/MT-CO2/TUBB/MT-CO1/TUBA1C/HSPA5/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/CHCHD10/COX5A/UQCR10/COX7B/COX8A/HNRNPA3/COX6C/MT-ND1/COX5B/NDUFS5/PSMA7/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/ACTG1/HNRNPA2B1/UQCRFS1/SRSF3/NDUFV3/SRSF7/MT-ND6/NDUFB2/TOMM40/MT-ATP6/NDUFV2/CYCS/NDUFS7/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB/ALYREF/NRG4	6.23103158127843
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	24/629	116/9376	3.08404144509621	ENO1/PHGDH/GAPDH/TPI1/GPT2/PKM/IDH2/ACAT2/PGAM1/ACAT1/GPI/IDH1/ECHS1/ACSS1/GCSH/ALDOC/ADH5/ALDOA/ESD/FH/TKT/PCCA/RPIA/MDH2	6.0563539752669
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/629	87/9376	3.42671271677357	UQCRH/MT-CO3/MT-CO2/MT-CO1/MT-CYB/MYL4/COX7C/COX5A/UQCR10/COX7B/COX8A/TPM2/COX6C/COX5B/COX8C/CYC1/UQCRFS1/TNNC1/FXYD2/UQCRB	6.09782432634553
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	50/629	388/9376	1.92090210283054	UQCRH/NDUFA4/MT-CO3/TUBA1B/MT-CO2/SLC25A6/TUBB/GAPDH/MT-CO1/TUBA1C/CALM3/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/COX6C/MT-ND1/COX5B/NDUFS5/PSMA7/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/DKK1/SLC25A5/FZD3/NDUFV3/MT-ND6/NDUFB2/MT-ATP6/PPIF/NDUFV2/CYCS/NDUFS7/HSD17B10/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB/LRP6	4.9679726153744
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	56/629	480/9376	1.73905670376259	UQCRH/RPS27A/NDUFA4/GPX3/MT-CO3/TUBA1B/MT-CO2/SLC25A6/TUBB/UBA52/MT-CO1/TUBA1C/CALM3/HSPA5/MT-CYB/NDUFC1/VDAC1/COX7C/NDUFA6/COX5A/UQCR10/COX7B/COX8A/COX6C/MT-ND1/COX5B/NDUFS5/PSMA7/COX8C/NDUFB11/MT-ND4/NDUFB1/CYC1/UQCRFS1/DKK1/SLC25A5/FZD3/NDUFV3/MT-ND6/NDUFB2/TOMM40/PRKCA/MT-ATP6/PPIF/NDUFV2/PARK7/CYCS/NDUFS7/HSD17B10/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/UQCRB/LRP6	4.45740801788948
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/629	75/9376	3.17998940116587	ENO1/PHGDH/ARG2/GAPDH/TPI1/ASS1/GPT2/PKM/IDH2/CBS/PGAM1/IDH1/ALDOC/ALDOA/TKT/RPIA	5.08278324100391
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/629	47/9376	3.8058383790549	LDHB/LDHA/PKM/ACAT2/ACAT1/ALDH7A1/ALDH2/ACSS1/ADH5/FH/GLO1/MDH2	5.17101064037968
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/629	67/9376	3.11472842464941	ENO1/GAPDH/LDHB/TPI1/LDHA/PKM/PGAM1/GPI/ALDH7A1/ALDH2/ACSS1/ALDOC/ADH5/ALDOA	4.6582402824537
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/629	20/9376	5.21717011128776	DHCR24/EBP/LBR/SQLE/DHCR7/CYP51A1/FDFT1	5.06258594128251
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	22/629	149/9376	2.20091548318947	NDUFA4/NDUFC1/NDUFA6/MT-ND1/ADCY5/NDUFS5/NDUFB11/MT-ND4/NDUFB1/NDUFV3/MT-ND6/NDUFB2/PRKCA/NDUFV2/NDUFS7/NDUFB4/MT-ND5/NDUFA1/NDUFA2/NDUFB9/GABRA3/GNG11	3.96238540865011
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	15/629	85/9376	2.63050593846442	RRM2/TK1/PNP/TYMS/NME1/IMPDH2/DTYMK/DUT/GMPS/NME2/NT5C3B/AK2/HDDC2/AK5/AK1	4.049319224759
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/629	59/9376	2.77912209317992	GPX3/RRM2/GGCT/GSTA4/MGST1/IDH2/MGST3/SRM/PRDX6/IDH1/GSTP1	3.67599666349106
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	21/629	157/9376	1.99382297246666	HLA-G/CCNE1/CCNB1/SLC25A6/CCNA2/CALM3/CCNB2/VDAC1/CDK1/HLA-C/E2F5/SLC25A5/CCND3/PPP1CC/E2F2/FOXM1/MYBL2/CDC25A/CDK4/CHEK1/E2F1	3.36742822497926
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	19/629	138/9376	2.05230294232852	CCNE1/PTTG1/CCNB1/CDC20/CALM3/CCNB2/ANAPC11/CDK1/MAD2L1/ADCY5/AURKA/PLK1/PPP1CC/CDC25C/SMC1A/BUB1/AR/FBXO5/PKMYT1	3.33943309316311
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/629	36/9376	3.31248895954778	SSBP1/POLD2/RPA3/RNASEH2A/POLE4/RNASEH2C/MCM7/PCNA	3.72768218289416
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/629	15/9376	4.96873343932167	TPK1/ACP1/AK2/AK5/AK1	4.12494189161268
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/629	41/9376	2.90852689131025	PHGDH/ALAS2/CBS/PGAM1/GAMT/ALDH7A1/GCSH/GCAT	3.28408544824074
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/629	194/9376	1.7672299346041	TUBA1B/TUBB/TUBA1C/MYO10/MYO1B/MYL4/TPM2/CENPE/KIF2C/ACTG1/KIF11/TNNC1/KIFC1/KIF20A/TNNI2/KIF18B/MYL6B/MYO7A/KIF4A/KIF23/KIF15/KIF14/KIF20B	2.89560393097822
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/629	50/9376	2.6831160572337	ARG2/CKMT1A/SRM/SAT2/CKB/CKMT1B/GAMT/ALDH7A1/ALDH2	3.19987311503234
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/629	43/9376	2.77324657078419	ACAT2/ACAT1/ECI2/ALDH7A1/ECHS1/ALDH2/ADH5/CPT1C	3.12517341473064
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/629	27/9376	3.31248895954778	SCD/HSD17B12/ELOVL6/FADS1/ELOVL5/ACOT4	3.22671321566748
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/629	44/9376	2.71021823963	HMGB1/PARP1/APEX1/POLD2/NTHL1/POLE4/PCNA/NEIL3	3.04910166245198
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/629	224/9376	1.66363842834431	HLA-G/CCNE1/PTTG1/SLC25A6/CDC20/RANBP1/CCNA2/RAN/CCNB2/ANAPC11/VDAC1/HLA-C/SLC2A1/MAD2L1/ADCY5/CALR/SLC25A5/CCND3/E2F2/CANX/IL1R1/CDK4/CHEK1/E2F1/BUB1B	2.6957457378937
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/629	75/9376	2.18624271330154	CCNE1/RRM2/CCNB1/CCNB2/CDK1/SIVA1/GTSE1/CCND3/CYCS/CDK4/CHEK1	2.76579995283807
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/629	75/9376	2.18624271330154	CGA/GPX3/GNAS/HSPA5/ADCY5/PDIA4/PRKCA/FXYD2/CANX/LRP2/HSP90B1	2.76579995283807
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/629	57/9376	2.35361057652079	SCD/HSD17B12/ELOVL6/ACAT2/ACAT1/FADS1/ECHS1/ELOVL5/CPT1C	2.74870358406489
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/629	233/9376	1.59937771651985	ENO1/COL1A1/COL3A1/LAMA1/LMNB1/MYL4/NID1/COL6A2/TPM2/COL6A1/LBR/LMNB2/COL6A3/ACTG1/DCN/COL1A2/COL27A1/TNNC1/TNNI2/CSRP2/SSPN/VCAN/ITGB5/ITGB8/FBN2	2.48436608061079
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/629	48/9376	2.48436671966084	ACAT2/MCCC2/ACAT1/ALDH7A1/ECHS1/HSD17B10/ALDH2/PCCA	2.76470600802576
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/629	78/9376	2.10215645509763	HSPD1/ENO1/LSM4/LSM7/LSM5/LSM2/PABPC4/EXOSC2/EXOSC8/LSM3/EXOSC5	2.62106129113484
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/629	31/9376	2.88507102928355	ACAT2/ACAT1/ACSS1/GCSH/PCCA/MDH2	2.81903397967798
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/629	59/9376	2.27382716714721	RRM2/TK1/TYMS/NME1/DTYMK/DUT/NME2/NT5C3B/HDDC2	2.63196350281277
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/629	23/9376	3.2404783299924	SSBP1/POLD2/RPA3/EXO1/PCNA	2.88476603625422
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/629	71/9376	2.0994648335162	LDHB/LDHA/SLC16A3/PKM/SLC2A1/IDH2/PGAM1/SLC1A5/IDH1/FGFR1	2.49363983059921
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/629	82/9376	1.9996122377758	RRM2/TK1/GSTA4/NME1/MGST1/MGST3/IMPDH2/DUT/GMPS/GSTP1/NME2	2.43791496986177
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/629	63/9376	2.12945718828072	EZH2/HYKK/ACAT2/ACAT1/DHTKD1/ALDH7A1/ECHS1/ALDH2/PLOD1	2.41199634121243
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/629	34/9376	2.63050593846442	POLR2L/POLR1D/POLR2I/POLR2H/POLR3G/POLR2F	2.55401421197533
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/629	54/9376	2.20832597303186	PHGDH/LDHB/LDHA/SRM/CBS/AHCY/ADI1/MDH2	2.38785438343822
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	13/629	110/9376	1.7616418557595	CCNB1/CCNA2/CCNB2/ANAPC11/CDK1/MAD2L1/ADCY5/AURKA/PLK1/CDC25C/CDC25A/BUB1/PKMYT1	2.15467808657924
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/629	89/9376	1.84233936514174	COL1A1/LAMA1/LAMA4/HMMR/COL6A2/COL6A1/FRAS1/COL6A3/COL1A2/ITGB5/ITGB8	2.14104490147043
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/629	243/9376	1.47221731535457	SNRPD2/HNRNPA1/SNRPF/SNRPD1/RBM8A/HNRNPC/LSM4/HNRNPA3/LSM7/SNRPG/SF3B5/SRSF3/LSM5/SRSF7/LSM2/SNRPB/HNRNPM/SNRPE/SNRPA/LSM3/RBMX/ALYREF/SRSF9/SNRPD3	1.99995264927324
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/629	28/9376	2.6618214853509	HSD17B12/ELOVL6/ECHS1/ELOVL5/ACOT4	2.36148630355714
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/629	70/9376	1.91651146945265	HLA-G/LAMA1/HLA-C/CAV1/ACTG1/CYCS/RAC3/SSPN/ABL1	2.06389119268386
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/629	39/9376	2.29326158737923	TYMS/CBS/AHCY/ALDH7A1/GCSH/DHFR	2.17018321450325
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/629	31/9376	2.40422585773629	GPI/ALDOC/ALDOA/TKT/RPIA	2.09995291774527
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/629	63/9376	1.8928508340273	POLR2L/POLD2/RPA3/POLR2I/POLR2H/POLE4/POLR2F/PCNA	1.90671498421336
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/629	42/9376	2.12945718828072	ACAT2/ACAT1/DHTKD1/ALDH7A1/ECHS1/ALDH2	1.96717011646334
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/629	32/9376	2.32909379968204	LDHB/LDHA/ECHS1/ACSS1/PCCA	2.01950812100823
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/629	23/9376	2.59238266399392	ACAT2/ACAT1/HMGCR/MVD	2.05029942236721
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/629	174/9376	1.45635290462877	PDIA6/HSPA5/OSTC/CALR/BAG2/PDIA3/LMAN1/SSR2/PDIA4/STT3B/SSR3/SSR4/RRBP1/TMEM258/CANX/MAN1A2/HSP90B1	1.62935503291153
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/629	128/9376	1.51391096979332	RRM2/PNP/PDE4D/PAICS/ADCY5/NME1/IMPDH2/GMPS/NME2/AK2/HDDC2/AK5/AK1	1.56982181535494
NA	NA	hsa04518	Integrin signaling	15/629	154/9376	1.45190262837322	COL1A1/LAMA1/LAMA4/COL6A2/COL6A1/FRAS1/COL6A3/ACTG1/COL1A2/CCND3/FLT4/RAC3/ITGB5/ITGB8/PGF	1.51626135568899
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/629	142/9376	1.46962538346134	MMP2/BMP4/GSTA4/CALM3/ASS1/TXN2/CAV1/MGST1/MGST3/ACTG1/GSTP1/RAC3/IL1R1/HSP90B1	1.5121058633736
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/629	106/9376	1.54686984431713	CCNE1/ETV5/SLC19A1/GRB2/FGFR1/E2F2/GSTP1/AR/ZEB1/E2F1/HSP90B1	1.51837288391555
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/629	37/9376	2.0143513943196	HBA2/HBA1/LAMA4/PRKCA/HBB	1.65775559560936
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/629	27/9376	2.20832597303186	ACAT2/ACAT1/ECHS1/ACSM3	1.68602810833683
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/629	50/9376	1.7887440381558	HBA2/HBA1/GYPA/GYPB/GYPC/HBB	1.49952870539714
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/629	52/9376	1.71994619053443	CGA/GNAS/ADCY5/LDLR/CYP2J2/ACOT4	1.39598893227471
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	18/629	203/9376	1.32173204789838	COL1A1/LAMA1/LAMA4/CAV1/COL6A2/COL6A1/COL6A3/ACTG1/COL1A2/CCND3/GRB2/PPP1CC/PRKCA/FLT4/RAC3/ITGB5/ITGB8/PGF	1.24270499286261
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/629	30/9376	1.98749337572867	IDH2/IDH1/FH/MDH2	1.45265782438994
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/629	30/9376	1.98749337572867	SLC19A1/TYMS/GGH/DHFR	1.45265782438994
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/629	89/9376	1.50736857147961	TUBA1B/GNAS/TUBB/GJA1/TUBA1C/CDK1/ADCY5/GRB2/PRKCA	1.28962142586077
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	14/629	154/9376	1.355109119815	GGH/ALAS2/NME1/VKORC1/TPK1/NME2/ALDH2/MMAB/AK2/DHFR/AK5/AK1/COQ3/UROS	1.19149170998743
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/629	103/9376	1.44720391436554	GNAS/COL1A1/ARG2/COL3A1/LAMA1/LAMA4/COL1A2/PRKCA/SERPINB6/IL1R1	1.22375780973516
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/629	33/9376	1.80681215975334	GPT2/IDH2/DHTKD1/IDH1	1.24499505990862
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/629	107/9376	1.39310283345468	GNAS/LDHB/CALM3/LDHA/PKM/SLC2A1/PGAM1/PYGL/PRMT1/CPT1C	1.09663731547514
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/629	12/9376	2.48436671966084	VKORC1/COQ3	1.37969320955813
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/629	23/9376	1.94428699799544	ARG2/ASS1/GPT2	1.2158328084802
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/629	110/9376	1.355109119815	RPS6/ENO1/GAPDH/LDHB/LDHA/SLC2A1/TIMP1/PRKCA/ALDOC/ALDOA	1.00460056524445
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/629	35/9376	1.70356575062457	AKR1B1/TPI1/ALDOC/ALDOA	1.11821013386244
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/629	24/9376	1.86327503974563	HS3ST3B1/HS6ST2/EXTL2	1.13549167264557
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/629	75/9376	1.39124536301007	BIRC5/TOP2A/GSTA4/MGST1/MGST3/GSTP1/CYCS	0.912213322305396
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/629	76/9376	1.37293950297046	GNAS/CALM3/ADCY5/GAST/ACTG1/PRKCA/CA2	0.875356794768772
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/629	103/9376	1.30248352292898	COL1A1/COL3A1/COL6A2/COL6A1/COL6A3/SLC1A5/COL1A2/COL27A1/FXYD2	0.827735539895071
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/629	51/9376	1.46139218803579	GNAS/ACTG1/PDIA4/PRKCA/ATP6V0A4	0.885956303695092
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/629	90/9376	1.32499558381911	GNAS/SLC2A1/ADCY5/LDLR/HMGCR/FXYD2/CA2/ABCB1	0.830741243682475
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/629	105/9376	1.27767431296843	GNAS/LAMA1/TPM2/ADCY5/ACTG1/TNNC1/SSPN/ITGB5/ITGB8	0.767270432642907
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/629	53/9376	1.40624531301557	GNAS/ATP2B1/PTH1R/PRKCA/FXYD2	0.795297933104808
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/629	93/9376	1.28225379079269	CCNE1/LAMA1/LAMA4/CKS1B/E2F2/CYCS/CDK4/E2F1	0.733531012972158
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	17/629	217/9376	1.1677668451862	GNAS/BIRC5/GSTA4/ADCY5/MGST1/MGST3/KPNA2/CDC6/CCND3/GRB2/PRKCA/KPNB1/CDC25A/AR/DLL1/E2F1/HSP90B1	0.670491648715977
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/629	28/9376	1.59709289121054	AKR1B1/GGH/DHFR	0.848482642073488
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/629	41/9376	1.45426344565512	SSBP1/POLD2/RPA3/XRCC2	0.781670920297859
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/629	41/9376	1.45426344565512	MMP2/E2F2/CDK4/E2F1	0.781670920297859
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/629	110/9376	1.2195982078335	BMP4/ID1/ID2/GREM2/E2F5/DCN/LRRC32/TFDP1/BMP7	0.621241391466184
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/629	56/9376	1.33091074267545	OSTC/STT3B/TMEM258/MAN1A2/DPM3	0.666006275393621
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/629	44/9376	1.355109119815	OSTC/STT3B/TMEM258/MAN1A2	0.633114407558903
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/629	31/9376	1.44253551464178	ALDH7A1/ECHS1/ALDH2	0.66179079387984
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/629	31/9376	1.44253551464178	SEC11A/HSPA5/SEC11C	0.66179079387984
NA	NA	hsa04981	Folate transport and metabolism	3/629	31/9376	1.44253551464178	SLC19A1/TYMS/DHFR	0.66179079387984
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/629	99/9376	1.20454143983556	MMP2/GNAS/ADCY5/GRB2/E2F2/DLL1/CDK4/E2F1	0.548626176817647
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/629	170/9376	1.13988590666791	GSTA4/MGST1/MGST3/ACTG1/FZD3/GRB2/PRKCA/E2F2/GSTP1/SMARCA2/CDK4/E2F1/LRP6	0.493564977256315
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/629	227/9376	1.11632337182998	HLA-G/GNAS/CALM3/HLA-C/ADCY5/CALR/PDIA3/GRB2/PRKCA/E2F2/CYCS/RAC3/IL1R1/CXCL12/GNG11/CDK4/E2F1	0.475745287331173
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/629	157/9376	1.13932741283809	BIRC5/BMP4/ID1/ID2/ACTG1/FRMD6/FZD3/CCND3/PPP1CC/DLG5/TEAD4/BMP7	0.472091182738348
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/629	115/9376	1.16657219879726	NACA/GNAS/PDE4D/GCM1/ADCY5/PTH1R/PRKCA/FGFR1/LRP6	0.481952119267893
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/629	19/9376	1.56907371768053	DHTKD1/GCSH	0.665822415303204
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/629	46/9376	1.29619133199696	ALAS2/CP/MMAB/UROS	0.539997608458457
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/629	130/9376	1.14663079368962	MMP2/GNAS/COL1A1/COL3A1/ADCY5/COL1A2/GRB2/PRKCA/RLN2/GNG11	0.451441327777323
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/629	61/9376	1.22181969819385	ATP2B1/MT1G/MT1E/MT1H/FXYD2	0.466074127896298
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/629	204/9376	1.09604414102684	RPS6/MMP2/COL1A1/CAV1/ACTG1/DCN/COL1A2/FZD3/LUM/GRB2/PPP1CC/PRKCA/FGFR1/EIF4B/ITGB5	0.371907841302528
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/629	76/9376	1.1768052882604	CALM3/GRB2/PRKCA/E2F2/CDK4/E2F1	0.414994145691366
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/629	105/9376	1.13571050041638	RPS27A/TOMM20/UBA52/PHB2/BNIP3/TOMM7/TOMM40/E2F1	0.374995631592692
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/629	21/9376	1.41963812552048	DSEL/CHSY1	0.516231008167509
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/629	93/9376	1.1219720669436	CGA/MMP2/GNAS/CALM3/ADCY5/GRB2/PRKCA	0.316985269066462
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/629	122/9376	1.09963772837447	LEP/CCNA2/SCD/EEF2/HMGCR/CAB39L/PPARG/CPT1C/EEF2K	0.297043725388759
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/629	122/9376	1.09963772837447	BMP4/SLC2A1/MED12L/DIO2/ACTG1/PRKCA/FXYD2/PLCD4/DIO3	0.297043725388759
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/629	36/9376	1.24218335983042	GYG2/PYGL/GPI	0.390394337540898
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/629	79/9376	1.13211647984544	GSTA4/MGST1/MGST3/CYP2S1/GSTP1/ADH5	0.316213583244989
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/629	22/9376	1.355109119815	ALDH7A1/ALDH2	0.447152724407467
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/629	65/9376	1.14663079368962	AKR1B1/AGPAT5/AGPAT4/ALDH7A1/ALDH2	0.318101046600259
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/629	37/9376	1.20861083659176	ASS1/GPT2/RIMKLA	0.340932918908945
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/629	37/9376	1.20861083659176	COMT/ADH5/FAH	0.340932918908945
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/629	23/9376	1.29619133199696	FUT4/B3GALNT2	0.381366194593198
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/629	23/9376	1.29619133199696	REN/ENPEP	0.381366194593198
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/629	23/9376	1.29619133199696	FXYD2/CA2	0.381366194593198
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/629	184/9376	1.05315545724753	SEMA6A/UNC5C/ROBO1/SEMA4G/FZD3/PRKCA/EPHB3/RAC3/BMP7/CXCL12/BOC/ABL1/ENAH	0.195268935919178
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/629	155/9376	1.05785937740397	HLA-G/TUBA1B/TUBB/TUBA1C/HLA-C/COLEC12/CALR/ACTG1/ATP6V0A4/CANX/ITGB5	0.194774452319795
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/629	214/9376	1.04482712509101	HLA-G/CCNB1/CALM3/CCNB2/CDK1/HLA-C/AP1S3/CALR/PDIA3/PRKCA/CYCS/RAC3/CDC25C/GNG11/CHEK1	0.177882828969723
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/629	333/9376	1.02955737931891	HLA-G/CCNE1/GNAS/COL1A1/CCNA2/LAMA1/LAMA4/PKM/HLA-C/COL6A2/COL6A1/COL6A3/MAGI1/COL1A2/FZD3/CCND3/GRB2/ATP6V0A4/HEY1/ITGB5/ITGB8/CDK4/E2F1	0.147269622659692
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/629	82/9376	1.09069758424134	HLA-G/HSPA5/HLA-C/CALR/PDIA3/CANX	0.221198770879657
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/629	200/9376	1.04343402225755	CLDN10/RPS3/TUBA1B/TUBB/GAPDH/TUBA1C/MYO10/MYO1B/NCL/ACTG1/PYCARD/CYCS/IL1R1/ABL1	0.16649444290429
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/629	142/9376	1.0497324167581	RPS27A/UBE2C/UBA52/CDC20/ANAPC11/SAE1/UBE2S/RHOBTB1/CBLB/CBLC	0.160129076553319
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/629	157/9376	1.04438346176825	ARG2/S1PR1/SLC2A1/CALR/ATP11B/UQCRFS1/BSG/PPARG/ITGB5/XKR8/CPT1C	0.150387066933802
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/629	83/9376	1.07755664949145	POLR2L/POLR1D/PYCARD/POLR2H/POLR3G/POLR2F	0.190309958354001
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/629	69/9376	1.0801594433308	GNAS/CALM3/ADCY5/PPP1CC/PRKCA	0.179207333831383
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/629	99/9376	1.05397375985611	GNAS/CALM3/ADCY5/PPP1CC/PRKCA/CYP2J2/IL1R1	0.144769771554064
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/629	99/9376	1.05397375985611	LAMA1/TPM2/ACTG1/TNNC1/SSPN/ITGB5/ITGB8	0.144769771554064
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/629	10/9376	1.4906200317965	SELENBP1	0.416245543901511
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/629	101/9376	1.03310299233421	MMP2/COL1A1/COL3A1/COL1A2/PRKCA/PLCD4/CDK4	0.0896917254508999
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/629	86/9376	1.03996746404407	GJA1/LAMA1/ACTG1/SSPN/ITGB5/ITGB8	0.0998456984196551
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/629	56/9376	1.06472859414036	HSPD1/BNIP3/PYCARD/CYCS	0.130275764232795
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/629	102/9376	1.02297453162505	GNAS/PLA2G2A/ATP2B1/ADCY5/PRKCA/FXYD2/CA2	0.062559692314141
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/629	148/9376	1.0071756971598	FZD3/GRB2/FGFR1/E2F2/FLT4/HEY1/DLL1/CDK4/E2F1/LRP6	0.0235951403003152
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/629	42/9376	1.06472859414036	SAT2/SLC7A11/CP	0.112737479025146
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/629	103/9376	1.01304274005588	RBM8A/PAPOLA/PPP1CC/PABPC4/MSI2/ALYREF/PNN	0.0356910002148968
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/629	73/9376	1.02097262451815	GSTA4/MGST1/MGST3/GSTP1/ADH5	0.0482374230524313
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/629	73/9376	1.02097262451815	GRB2/PRKCA/E2F2/CDK4/E2F1	0.0482374230524313
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/629	134/9376	1.00116270792302	GNAS/CALM3/PLA2G2A/ADCY5/PPP1CC/PRKCA/MYL6B/PPP1R14A/RAMP2	0.00363514255417587
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/629	362/9376	0.988256374671714	RPS6/CCNE1/COL1A1/LAMA1/LAMA4/COL6A2/COL6A1/COL6A3/MAGI1/COL1A2/CCND3/SGK2/GRB2/PRKCA/FGFR1/FLT4/EIF4B/ITGB5/ITGB8/GNG11/PRLR/CDK4/HSP90B1/PGF	-0.0611053298808184
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/629	43/9376	1.03996746404407	PLA2G2A/ACAT2/ACAT1	0.0704387410880468
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/629	28/9376	1.06472859414036	ATP6V0A4/CA2	0.0919808113316638
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/629	44/9376	1.01633183986125	HLA-G/HSPD1/HLA-C	0.0291175938356354
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/629	137/9376	0.979239436946607	TUBA1B/BIRC5/TUBA1C/LMNB1/PARP1/CTSC/LMNB2/ACTG1/CYCS	-0.065639962708528
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/629	91/9376	0.9828263945911	GNAS/PDE4D/ADCY5/PRKCA/GABRA3/GNG11	-0.0441440952126059
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/629	76/9376	0.98067107355033	SLC27A2/DBI/SCD/PPARG/CPT1C	-0.0453685033860414
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/629	29/9376	1.02801381503207	FRMD6/TEAD4	0.0405150642587768
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/629	154/9376	0.967935085582144	GNAS/CALM3/MYL4/ATP2B1/TPM2/ADCY5/PPP1CC/PRKCA/TNNC1/FXYD2	-0.107586872818797
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/629	108/9376	0.966142613201437	RAN/RBM8A/KPNA2/IPO5/KPNB1/ALYREF/PNN	-0.0948972654298881
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/629	170/9376	0.964518844103619	CLDN10/TUBA1B/JAM3/TUBA1C/ACTG1/MAGI1/RAB13/EPB41L4B/MYL6B/CDK4/PCNA	-0.125189565697985
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/629	13/9376	1.14663079368962	XRCC6	0.141863525178925
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/629	77/9376	0.967935085582144	RALBP1/E2F2/RAC3/CDK4/E2F1	-0.0757597829059567
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/629	77/9376	0.967935085582144	GRB2/E2F2/ABL1/CDK4/E2F1	-0.0757597829059567
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/629	155/9376	0.961690343094518	CCNE1/GNAS/ADCY5/LDLR/FZD3/E2F2/WDR5/FH/CDK4/E2F1	-0.1289634070935
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/629	93/9376	0.961690343094518	GNAS/CALM3/ATP2B1/ADCY5/PRKCA/FXYD2	-0.0995604748392348
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/629	30/9376	0.993746687864335	PLA2G2A/CYP2J2	-0.00919897087463832
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/629	173/9376	0.947793083801244	SLC25A6/VDAC1/KPNA2/ACTG1/SLC25A5/CCND3/PRKCA/PYCARD/CYCS/TMPRSS4/CDK4	-0.185852231047271
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/629	31/9376	0.961690343094518	ALDH7A1/ALDH2	-0.0572902680528729
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/629	160/9376	0.931637519872814	HLA-G/CLDN10/JAM3/CNTNAP2/HLA-C/SELL/PTPRS/VCAN/ITGB8/NRXN3	-0.233877243243795
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/629	32/9376	0.931637519872814	BIRC5/CYCS	-0.103874221535112
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/629	98/9376	0.912624509263165	GNAS/CALM3/ATP2B1/ADCY5/LDLR/PRKCA	-0.233161520801403
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/629	178/9376	0.921169682570872	NOTUM/LGR5/RNF43/DKK1/FZD3/CCND3/PRKCA/RAC3/FRZB/CACYBP/LRP6	-0.284733109884824
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/629	83/9376	0.897963874576206	SLC27A2/PHYH/IDH2/ECI2/IDH1	-0.250378154643558
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/629	116/9376	0.899512088153062	CLDN10/MMP2/JAM3/ACTG1/PRKCA/THY1/CXCL12	-0.292024117760469
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/629	34/9376	0.876835312821472	BHLHE41/RORB	-0.192924388710726
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/629	133/9376	0.896613552960302	CCNB1/S1PR1/CCNB2/BNIP3/SGK2/PLK1/GRB2/PRMT1	-0.322006287871355
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/629	52/9376	0.859973095267213	VDAC1/LDLR/LRP2	-0.27151474901555
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/629	69/9376	0.864127554664639	GNAS/CALM3/ADCY5/REN	-0.303761324404618
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/629	86/9376	0.866639553370059	CBLB/GRB2/PRKCA/ABL1/NRG4	-0.333157663459479
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/629	86/9376	0.866639553370059	GNAS/SLC2A1/ADCY5/PRKCA/FXYD2	-0.333157663459479
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/629	17/9376	0.876835312821472	CA2	-0.136294189964966
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/629	70/9376	0.851782875312287	GSTA4/MGST1/MGST3/GSTP1	-0.333769983730358
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/629	36/9376	0.828122239886946	AKR1B1/DCXR	-0.277063231529755
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/629	104/9376	0.859973095267213	PLA2G2A/AGPAT5/PHOSPHO1/AGPAT4/CHPT1/GPD1L	-0.385055068809897
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/629	71/9376	0.83978593340648	CGA/ELF5/GRB2/PRLR	-0.363373311906831
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/629	54/9376	0.828122239886946	FANCI/UBE2T/RPA3	-0.339659224465483
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/629	54/9376	0.828122239886946	HLA-G/CGA/HLA-C	-0.339659224465483
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/629	154/9376	0.87114157702393	GNAS/CALM3/ADCY5/EEF2/ACTG1/PPP1CC/PRKCA/MYL6B/EEF2K	-0.432356518520353
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/629	18/9376	0.828122239886946	FUCA1	-0.195724780716117
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/629	18/9376	0.828122239886946	MMAB	-0.195724780716117
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/629	37/9376	0.805740557727839	GPI/GNPNAT1	-0.317478419441264
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/629	89/9376	0.837426984155338	ADCY5/SLC6A11/PRKCA/GABRA3/GNG11	-0.413225525358549
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/629	205/9376	0.872558067393075	HLA-G/CCNE1/CDC20/RANBP1/CCNA2/CDK1/PKM/HLA-C/CCND3/GRB2/CDK4/CHEK1	-0.494723260569223
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/629	73/9376	0.816778099614522	PPIA/RAN/PSIP1/MAP1B	-0.421413748847462
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/629	73/9376	0.816778099614522	FGFR1/E2F2/CDK4/E2F1	-0.421413748847462
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/629	38/9376	0.784536858840264	GPI/GNPNAT1	-0.35687756592626
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/629	38/9376	0.784536858840264	PNP/NNMT	-0.35687756592626
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/629	38/9376	0.784536858840264	PRKCA/FXYD2	-0.35687756592626
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/629	39/9376	0.764420529126411	HLA-G/HLA-C	-0.395318795795564
Organismal Systems	Immune system	hsa04611	Platelet activation	7/629	126/9376	0.828122239886946	GNAS/COL1A1/COL3A1/ADCY5/ACTG1/COL1A2/PPP1CC	-0.520853382922948
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/629	144/9376	0.828122239886946	BMP4/ID1/ID2/FZD3/GRB2/FGFR1/TBX3/DLX5	-0.557358246483142
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	8/629	144/9376	0.828122239886946	SLC25A6/VDAC1/PSMA7/SLC25A5/NOP56/PRKCA/PPIF/CYCS	-0.557358246483142
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/629	59/9376	0.757942389049069	CGA/GNAS/ADCY5	-0.500135979222116
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/629	21/9376	0.709819062760239	ALDH2	-0.356975185694761
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	12/629	212/9376	0.843747187809341	GNAS/CALM3/ID1/ADCY5/ACTG1/MAGI1/PRKCA/FGFR1/FLT4/RAC3/ENAH/PGF	-0.617070280412405
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/629	163/9376	0.823041735347762	CCNE1/BIRC5/CCNA2/GRB2/PRKCA/E2F2/CYCS/E2F1/PCNA	-0.611146761848846
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/629	180/9376	0.828122239886946	HLA-G/HLA-C/CALR/PDIA3/SRSF3/SRSF7/PPP1CC/CYCS/ALYREF/SRSF9	-0.62436400004036
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/629	97/9376	0.768360841132218	GNAS/CALM3/ADCY5/PRKCA/GNG11	-0.614934213263272
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/629	166/9376	0.808167487118586	SLC25A6/CALM3/VDAC1/ATP2B1/ADCY5/SLC25A5/PPP1CC/FXYD2/PPIF	-0.668694640483445
NA	NA	hsa04517	IgSF CAM signaling	17/629	299/9376	0.847509717074934	TUBA1B/JAM3/TUBB/CNTNAP2/TUBA1C/CLMP/UNC5C/ROBO1/MTSS1/ACTG1/MAGI1/GRB2/PRKCA/FGFR1/MYL6B/PTPRS/ABL1	-0.718601292982027
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/629	133/9376	0.784536858840264	GNAS/COMT/CALM3/ADCY5/PPP1CC/PRKCA/GNG11	-0.671079123468746
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/629	63/9376	0.709819062760239	PTGDS/PLA2G2A/CYP2J2	-0.61969180078204
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/629	44/9376	0.677554559907501	TAF4B/TAF15	-0.574879219887633
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/629	45/9376	0.662497791909557	ABCA7/ABCB1	-0.608555481105866
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/629	45/9376	0.662497791909557	HLA-G/HLA-C	-0.608555481105866
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/629	101/9376	0.73793070881015	GNAS/CALM3/ADCY5/FZD3/PRKCA	-0.710070155507385
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/629	83/9376	0.718371099660965	AURKB/EZH2/TFDP1/WDR5	-0.691066267641117
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/629	205/9376	0.799844895110318	HLA-G/CCNE1/CCNA2/HLA-C/CALR/PDIA3/CCND3/E2F2/CYCS/CDK4/E2F1	-0.776992188403279
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/629	65/9376	0.68797847621377	GNAS/ADCY5/LDLR	-0.676899925184237
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/629	65/9376	0.68797847621377	CGA/PRKCA/KISS1R	-0.676899925184237
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/629	156/9376	0.764420529126411	CLDN10/LDLR/EIF3E/GRB2/E2F2/CYCS/CDK4/E2F1	-0.795638295456119
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/629	26/9376	0.573315396844809	PLA2G2A	-0.584210338084311
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/629	26/9376	0.573315396844809	SLC19A1	-0.584210338084311
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/629	67/9376	0.667441805282016	CALM3/PPP1CC/PRKCA	-0.732546061630689
NA	NA	hsa03272	Virion - Hepatitis viruses	2/629	48/9376	0.621091679915209	CLDN10/LDLR	-0.705735378699898
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/629	68/9376	0.657626484616104	CCNA2/DUSP6/GRB2	-0.759814940116129
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/629	87/9376	0.685342543354714	BIRC5/GRB2/CYCS/RAC3	-0.790668743084133
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/629	49/9376	0.608416339508776	GNAS/ADCY5	-0.736941495099025
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/629	69/9376	0.648095665998479	GRB2/PRKCA/RAC3	-0.786729982640619
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/629	125/9376	0.715497615262321	S1PR1/S1PR3/DEGS2/CERS4/PRKCA/RAC3	-0.858673331239413
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/629	196/9376	0.760520424385971	HLA-G/RPS27A/UBA52/CALM3/HLA-C/E2F2/CYCS/GNG11/CDK4/E2F1	-0.908566192062217
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/629	28/9376	0.532364297070179	FUT4	-0.664521019410161
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/629	70/9376	0.638837156484215	LEP/SLC2A1/CPT1C	-0.813302219013202
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/629	70/9376	0.638837156484215	SLC2A1/GRB2/FH	-0.813302219013202
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/629	51/9376	0.584556875214315	PLA2G2A/CHPT1	-0.797725806320146
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/629	29/9376	0.514006907516035	CALM3	-0.702868971925747
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/629	201/9376	0.741602005868907	ETV5/CCNA2/ID2/DUSP6/PPARG/ETV4/ZEB1/TLX3/TAF15/MYCN	-0.993037223114302
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/629	30/9376	0.496873343932167	PGAP2	-0.74012736850693
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/629	93/9376	0.641126895396345	ACTG1/FGFR1/ACP1/RAC3	-0.932651962650628
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/629	112/9376	0.665455371337724	LAMA1/LAMA4/LDLR/PPIF/CYCS	-0.955091977622608
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/629	168/9376	0.709819062760239	HMGB1/SLC25A6/PPIA/PARP1/VDAC1/PYGL/SLC25A5/PYCARD	-1.01770582970894
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/629	150/9376	0.695622681505034	CCNE1/FZD3/GRB2/E2F2/ABCB1/E2F1/LRP6	-1.00770308639055
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/629	55/9376	0.542043647926001	DEGS2/CERS4	-0.913388576468668
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/629	32/9376	0.465818759936407	AKR1B1	-0.811668335716226
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/629	115/9376	0.648095665998479	GNAS/ADCY5/PRKCA/CYP2J2/GNG11	-1.01818335098051
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/629	116/9376	0.642508634395044	SLC1A2/GNAS/ADCY5/PRKCA/GNG11	-1.03889212870487
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/629	56/9376	0.532364297070179	LRP2/BOC	-0.941185258088858
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/629	136/9376	0.657626484616104	CCNE1/CBLB/CCND3/CYCS/CDK4/EIF3H	-1.07848728253916
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/629	98/9376	0.608416339508776	CALM3/PRKCA/IMPA2/PLCD4	-1.04494110454962
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/629	78/9376	0.573315396844809	TPI1/IMPA2/PLCD4	-1.01470756867657
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/629	99/9376	0.602270719917779	GRB2/PRKCA/RAC3/CHPT1	-1.06679944423669
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/629	79/9376	0.566058239922722	SLC1A2/SLC6A11/ATP6V0A4	-1.03861591706195
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/629	138/9376	0.648095665998479	RPS6/CALM3/PYGL/CBLB/GRB2/PPP1CC	-1.11675158485429
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/629	80/9376	0.558982511923688	RPS6/GRB2/PRKCA	-1.0622681125985
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/629	139/9376	0.643433107250289	MMP2/GNAS/CALM3/ADCY5/GRB2/HSP90B1	-1.13570187405451
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/629	158/9376	0.660401279909843	RPS6/FZD3/GRB2/PRKCA/EIF4B/CAB39L/LRP6	-1.15440349787031
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/629	140/9376	0.638837156484215	RPS6/CALM3/MYL4/ADCY5/TFAM/GNG11	-1.15453344176167
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/629	60/9376	0.496873343932167	PRKCA/RAC3	-1.04838213117035
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/629	60/9376	0.496873343932167	GNAS/PRKCA	-1.04838213117035
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/629	216/9376	0.690101866572455	HSPD1/CALM3/HSPA5/LDLR/PRKCA/PYCARD/CYCS/CYP2J2/PPARG/HSP90B1	-1.23560454411802
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/629	37/9376	0.40287027886392	PPARG	-0.975889757791473
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/629	323/9376	0.738387631849661	CCNE1/STMN1/IGF2BP1/EZH2/CDCA5/FZD3/GRB2/PRKCA/E2F2/CDC25C/CDC25A/ABCB1/ZEB1/ABL1/KIF23/E2F1	-1.28305321948849
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/629	254/9376	0.704229936281812	GNAS/SLC25A6/CALM3/VDAC1/ATP2B1/SLC25A5/PRKCA/FGFR1/TNNC1/PPIF/FLT4/PLCD4	-1.2814670297557
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/629	62/9376	0.480845171547259	HEY1/DLL1	-1.09978052066071
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/629	105/9376	0.567855250208191	CALM3/CBLB/PYCARD/IL17D	-1.19410357260817
NA	NA	hsa04081	Hormone signaling	10/629	219/9376	0.680648416345435	CGA/LEP/GNAS/ADCY5/DIO2/GAST/PTH1R/GNG11/PRLR/RAMP2	-1.28231854211215
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	11/629	238/9376	0.688942031502585	CALM3/PLA2G2A/GRB2/PRKCA/FGFR1/RALBP1/FLT4/RAC3/ABL1/GNG11/PGF	-1.30342375158956
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/629	63/9376	0.473212708506826	BMP4/FZD3	-1.12497315778112
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/629	109/9376	0.547016525429909	SLC27A2/SLC2A1/PYGL/PPP1CC	-1.27557918503723
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/629	149/9376	0.600249677233491	GNAS/ADCY5/AGPAT5/GRB2/PRKCA/AGPAT4	-1.31896446353277
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/629	66/9376	0.451703039938334	COMT/HSD17B12	-1.19865544613352
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/629	41/9376	0.363565861413781	GABRA3	-1.09513997565931
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/629	68/9376	0.438417656410736	CYP2S1/ADH5	-1.24629574307494
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/629	133/9376	0.560383470600189	HLA-G/HLA-C/GRB2/PRKCA/RAC3	-1.36922479466353
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/629	44/9376	0.338777279953751	GNAS	-1.1788760336109
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/629	71/9376	0.41989296670324	JAM3/ATP6V0A4	-1.31571102607551
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/629	46/9376	0.32404783299924	PSMA7	-1.23235393538279
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/629	47/9376	0.317153198254575	PKM	-1.2584502742329
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/629	48/9376	0.310545839957605	FXYD2	-1.28414227648751
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/629	122/9376	0.488727879277542	GNAS/ADCY5/GRB2/PRKCA	-1.52422358382194
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/629	100/9376	0.447186009538951	CCR7/CXCL14/CXCL12	-1.49032179639859
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/629	144/9376	0.517576399929341	SCD/ALDH7A1/ALDH2/ADH5/CPT1C	-1.56438373190695
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/629	50/9376	0.2981240063593	CXCL12	-1.33437864399486
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/629	78/9376	0.382210264563206	CAV1/ACTG1	-1.46917867615299
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/629	78/9376	0.382210264563206	CALM3/PYCARD	-1.46917867615299
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/629	226/9376	0.593609747175598	CGA/GNAS/CALM3/PDE4D/ATP2B1/ADCY5/PPP1CC/FXYD2/RAC3	-1.65832005580981
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	10/629	248/9376	0.601056464434074	RPS3/TUBA1B/TUBB/GAPDH/TUBA1C/TXN2/ACTG1/PYCARD/CYCS/HSP90B1	-1.70738261328986
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/629	105/9376	0.425891437656144	PARP1/IL1R1/CXCL12	-1.58637837365838
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/629	191/9376	0.546300535213378	GNAS/CALM3/ADCY5/GRB2/PPP1CC/GNG11/SLC29A2	-1.69873943176693
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/629	193/9376	0.540639389770752	CCR7/CXCL14/ADCY5/GRB2/RAC3/CXCL12/GNG11	-1.72910557912303
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/629	195/9376	0.535094370388488	HMGB1/SLC25A6/VDAC1/ACTG1/SLC25A5/PRKCA/PPIF	-1.75921336108302
NA	NA	hsa04082	Neuroactive ligand signaling	7/629	199/9376	0.524338704652036	SLC1A2/GNAS/ADCY5/SLC6A11/PRKCA/GABRA3/GNG11	-1.81867620325486
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/629	59/9376	0.252647463016356	GRB2	-1.54416913990041
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/629	115/9376	0.388857399599088	ADCY5/PRKCA/GNG11	-1.76825108610472
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/629	90/9376	0.331248895954778	ADCY5/PPARG	-1.70943591712855
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/629	62/9376	0.240422585773629	ADCY5	-1.60909308421474
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/629	91/9376	0.327608798197033	GRB2/RAC3	-1.72835584175743
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/629	117/9376	0.382210264563206	CECR2/ACTG1/SMARCA2	-1.80315464394674
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/629	94/9376	0.317153198254575	IL17D/HSP90B1	-1.78421761235766
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/629	120/9376	0.372655007949126	CALM3/GRB2/ABL1	-1.85467058096122
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/629	95/9376	0.313814743536106	ATP6V0A4/CXCL12	-1.80254948619981
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/629	232/9376	0.514006907516035	ACTG1/PPP1CC/FGFR1/RAC3/ITGB5/ITGB8/CXCL12/ENAH	-2.00995983036214
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/629	253/9376	0.530260090362392	RPS27A/UBA52/VDAC1/BNIP3/ACTG1/PYCARD/CYCS/PLCD4/IL1R1	-2.03109520424184
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/629	122/9376	0.366545909458156	CBLB/GRB2/CDK4	-1.88847704566408
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/629	98/9376	0.304208169754388	MYO10/PRKCA	-1.85672068829784
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/629	100/9376	0.2981240063593	GYPA/IL1R1	-1.89217550521699
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/629	103/9376	0.289440782873107	GNAS/CALR	-1.94442034898554
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/629	370/9376	0.564018390409487	CGA/LEP/TMEM97/S1PR1/S1PR3/CHRNA5/PTH1R/GAL/KISS1R/RLN2/GZMA/NPW/GABRA3/PRLR	-2.29448096314997
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/629	183/9376	0.407273232731285	RAN/FBL/NOP56/POP7/GNL3	-2.17136509742521
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/629	138/9376	0.32404783299924	ACTG1/PYCARD/RAC3	-2.14510189516599
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	10/629	298/9376	0.500208064361242	CCR7/LEP/BMP4/CXCL14/ACVRL1/IL1R1/BMP7/CXCL12/IL17D/PRLR	-2.35116812216101
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/629	300/9376	0.496873343932167	STMN1/DUSP6/GRB2/PRKCA/FGFR1/FLT4/RAC3/MAP3K13/IL1R1/PGF	-2.37504645474157
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/629	142/9376	0.31491972502743	GRB2/PPARG/IL1R1	-2.20583030038217
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/629	168/9376	0.35490953138012	LEP/CCND3/GRB2/PRLR	-2.26242404773021
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/629	143/9376	0.312717489188077	SNRPD1/SNRPB/SNRPD3	-2.22081964877702
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/629	169/9376	0.352809474981421	HMGB1/RPS27A/UBA52/BNIP3	-2.27665817393875
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/629	86/9376	0.173327910674012	GABRA3	-2.06517111097602
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/629	88/9376	0.169388639976875	TFPI	-2.09922745110539
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/629	250/9376	0.417373608903021	HLA-G/HLA-C/CAV1/LDLR/CBLB/CBLC/PSD3	-2.50380972915598
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/629	93/9376	0.160281723849086	DLL1	-2.18228919436772
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/629	181/9376	0.329418791557238	HSPD1/CALM3/ATP6V0A4/CYCS	-2.44284660774415
NA	NA	hsa04519	Cadherin signaling	14/629	404/9376	0.516551496167105	GJA1/MYO1B/ACTG1/CIB2/FZD3/PPP1CC/FGFR1/FLT4/RAC3/TEAD4/MYO7A/GABRA3/LRP6/ENAH	-2.66365312639749
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/629	250/9376	0.357748807631161	LAPTM4B/CTSC/AP1S3/ATP6V0A4/FUCA1/SLC29A2	-2.76004453040209
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/629	109/9376	0.136754131357477	IL1R1	-2.43085790856903
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/629	187/9376	0.239136903496765	VDAC1/TXN2/PYCARD	-2.81821807228161
NA	NA	hsa04382	Cornified envelope formation	3/629	217/9376	0.206076502091682	CLDN10/PADI1/S100A1	-3.17296945338691
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/629	449/9376	0.0331986644052673	CALM3	-5.62974912994555