category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	129/1085	222/9376	5.02139743430066	RPL29/RPS7/RPS18/RPS4X/RPS3A/RPL13/RPL11/RPLP0/RPS2/RPL6/RPS6/RPL7A/RPL18A/RPL14/RPL37/RPL36/RPS15/RPSA/RPL19/RPS8/RPL18/RPL8/RPL37A/RPS27A/RPS24/RPS23/RPL24/RPS13/RPL10/RPL5/RPL39/RPS14/RPL13A/RPL21/RPL32/RPS9/RPL35A/RPS5/RPL35/RPS19/RPS27/RPLP2/RPS11/RPL23A/RPL15/RPL22/RPS3/RPL28/RPL10A/RPS26/RPS16/RPL38/RPL3/RPL36AL/RPL23/RPL12/RPL27A/RPL7/RPL9/RPL30/RPL27/UBA52/RPL4/RPLP1/RPS25/RPS12/RPS29/FAU/RPS21/RPL26/RPS15A/RPL34/RPL41/MRPS15/MRPL51/RPS20/RPL22L1/RPL31/RPS28/RPS27L/MRPL41/MRPL14/MRPL13/MRPL20/MRPL23/MRPS18C/MRPL11/RPL26L1/RPS10/MRPL52/MRPS33/MRPL22/MRPL40/MRPL35/MRPL47/MRPS21/MRPL16/MRPL17/MRPL12/RPL36A/RSL24D1/MRPS16/MRPL21/MRPL3/MRPS28/MRPS12/MRPL27/MRPL24/MRPL43/MRPL50/MRPL37/MRPS23/MRPL18/MRPS7/MRPS34/MRPL34/MRPS18B/MRPS9/MRPL19/MRPL9/MRPL42/MRPS14/MRPL4/MRPS35/MRPL33/MRPL32/MRPL54/MRPL15/MRPL45	21.9353758102524
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	115/1085	268/9376	3.70809546736364	TUBA1C/TUBA1B/CALM1/TUBB/CALM3/HSPA5/RPS27A/MT-CO3/PSMA7/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/TUBB6/UBA52/COX6B1/COX5A/MT-CO2/PSMB1/PARK7/NDUFS5/PSMA4/UBE2L3/NDUFV2/NDUFA6/NDUFC2/SLC39A10/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/PSMB3/PSMB2/NDUFA12/TXN2/NDUFB9/PSMB5/PSMB6/NDUFB7/TXN/SLC25A6/PSMA1/PSMD4/NDUFC1/PSMA3/GNAI1/NDUFA3/NDUFB3/SLC39A6/UQCRFS1/UQCRB/NDUFS8/CALM2/COX8A/PSMB4/SNCA/VDAC2/PSMD2/ADRM1/GNAI3/PSMB7/UQCR10/UBA1/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/NDUFS3/NDUFB10/UQCRC1/PSMC3/PSMD7/GNAS/NDUFS2/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/PSMD11/KIF5B/PSMD14/UQCRQ/COX7A2L/CYCS/PSMD8/PSMC5/SDHC/PSMD12/PSMC4/NDUFA8/SLC39A1/VDAC3/ADCY5/SLC39A4/CYC1/EIF2S1/PSMC2/PSMD6/NDUFS6/PSMA5/PSMD1/SLC39A3/MT-ATP8/PSMC6/ATF6/SLC25A4	16.2710996945217
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	111/1085	308/9376	3.11429768388294	TUBA1C/TUBA1B/TUBB/MT-CO3/PSMA7/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/TUBB6/COX6B1/COX5A/MT-CO2/PSMB1/NDUFS5/PSMA4/NDUFV2/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/PSMB3/PSMB2/NDUFA12/NDUFB9/PSMB5/PSMB6/NDUFB7/POLR2F/SLC25A6/PSMA1/PSMD4/NDUFC1/POLR2I/PSMA3/NDUFA3/NDUFB3/UQCRFS1/UQCRB/NDUFS8/COX8A/CLTA/NRBF2/PSMB4/VDAC2/PSMD2/AP2M1/ADRM1/PSMB7/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/NDUFS3/NDUFB10/UQCRC1/POLR2J/PSMC3/PSMD7/NDUFS2/NDUFA11/MT-ND6/NDUFB6/PPARG/NDUFB1/NDUFA1/POLR2H/PSMD11/KIF5B/PSMD14/UQCRQ/RCOR1/COX7A2L/CYCS/PSMD8/PSMC5/SDHC/PSMD12/POLR2K/POLR2G/PSMC4/POLR2L/NDUFA8/VDAC3/HDAC2/DCTN3/REST/CYC1/TFAM/PSMC2/PSMD6/NDUFS6/TBPL1/PSMA5/CREB3/PSMD1/MT-ATP8/PSMC6/GPX8/SLC25A4	13.648432815882
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	103/1085	275/9376	3.23662505236699	TUBA1C/TUBA1B/TUBB/HSPA5/MT-CO3/CYBA/PSMA7/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/TUBB6/COX6B1/COX5A/MT-CO2/PSMB1/NDUFS5/PSMA4/RAC1/NDUFV2/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/PSMB3/PSMB2/NDUFA12/NDUFB9/PSMB5/PSMB6/NDUFB7/SLC25A6/PSMA1/PSMD4/NDUFC1/PSMA3/NDUFA3/NDUFB3/UQCRFS1/UQCRB/NDUFS8/COX8A/PSMB4/VDAC2/PSMD2/ADRM1/CAV1/PSMB7/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/BAD/NDUFS3/NDUFB10/UQCRC1/PSMC3/PSMD7/NDUFS2/GRIN2D/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/CSNK2B/PSMD11/KIF5B/PSMD14/UQCRQ/COX7A2L/CYCS/PSMD8/PSMC5/SDHC/PSMD12/PSMC4/STIP1/NDUFA8/VDAC3/CYC1/EIF2S1/PRKCD/PSMC2/PSMD6/NDUFS6/PSMA5/CREB3/PSMD1/MT-ATP8/PSMC6/SLC25A4	13.6179590708302
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	122/1085	388/9376	2.71716471091263	GAPDH/TUBA1C/TUBA1B/CALM1/TUBB/CALM3/MT-CO3/PSMA7/NDUFA4/MT-CO1/UQCRH/COX5B/APP/COX6C/TUBB6/COX6B1/COX5A/MT-CO2/PSMB1/NDUFS5/PSMA4/NDUFV2/HSD17B10/NDUFA6/NDUFC2/SLC39A10/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/PSMB3/PSMB2/NDUFA12/NDUFB9/PSMB5/PSMB6/NDUFB7/SLC25A6/PSMA1/PSMD4/NDUFC1/PSMA3/NDUFA3/AKT1/NDUFB3/SLC39A6/UQCRFS1/UQCRB/NDUFS8/CALM2/COX8A/NRBF2/NOS2/PSMB4/SNCA/VDAC2/PSMD2/WNT10B/ADRM1/PSMB7/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/BAD/CSNK1E/NDUFS3/MAP2K2/NDUFB10/UQCRC1/PSMC3/LRP6/AXIN1/PSMD7/NDUFS2/GRIN2D/PSENEN/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/CAPN1/CSNK2B/PSMD11/KIF5B/PSMD14/UQCRQ/COX7A2L/WNT7A/CYCS/PSMD8/DKK1/PSMC5/SDHC/PSMD12/PSMC4/NDUFA8/SLC39A1/VDAC3/SLC39A4/HRAS/CYC1/EIF2S1/PSMC2/PSMD6/NDUFS6/PSMA5/PSMD1/SLC39A3/MT-ATP8/PSMC6/ATF6/SLC25A4	12.496642200961
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	89/1085	238/9376	3.2314758161329	RPL29/RPS7/RPS18/RPS4X/RPS3A/RPL13/RPL11/RPLP0/RPS2/RPL6/RPS6/RPL7A/RPL18A/RPL14/RPL37/RPL36/RPS15/RPSA/RPL19/RPS8/RPL18/RPL8/RPL37A/RPS27A/RPS24/RPS23/RPL24/RPS13/RPL10/RPL5/RPL39/RPS14/RPL13A/RPL21/RPL32/RPS9/RPL35A/RPS5/RPL35/RPS19/RPS27/RPLP2/RPS11/RPL23A/RPL15/RPL22/RPS3/RPL28/RPL10A/RPS26/RPS16/RPL38/RPL3/RPL36AL/RPL23/RPL12/RPL27A/RPL7/RPL9/RPL30/RPL27/UBA52/RPL4/RPLP1/RPS25/RPS12/RPS29/FAU/RPS21/RPL26/RPS15A/RPL34/RPL41/RPS20/RPL22L1/ISG15/RPL31/RPS28/RPS27L/RPL26L1/RPS10/RPL36A/RSL24D1/JAK1/MX1/IFNAR1/MMP3/C1R/IFNAR2	12.6139799363888
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	111/1085	368/9376	2.60653175716289	ACTB/PFN1/TUBA1C/TUBA1B/TUBB/HSPA5/MT-CO3/ACTG1/PSMA7/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/TUBB6/COX6B1/COX5A/MT-CO2/PSMB1/HNRNPA1/NDUFS5/PSMA4/RAC1/NDUFV2/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/CHCHD10/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/PSMB3/PSMB2/NDUFA12/NDUFB9/PSMB5/PSMB6/NDUFB7/PSMA1/HNRNPA3/PSMD4/NDUFC1/PSMA3/ALYREF/NDUFA3/NDUFB3/UQCRFS1/UQCRB/TANK/NDUFS8/COX8A/NRBF2/NOS2/CHMP2B/PSMB4/PSMD2/ADRM1/PSMB7/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/BAD/NDUFS3/NDUFB10/UQCRC1/NUP37/PSMC3/PSMD7/NDUFS2/GRIN2D/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/PSMD11/KIF5B/PSMD14/UQCRQ/COX7A2L/CYCS/PSMD8/PSMC5/SDHC/PSMD12/PSMC4/NDUFA8/DCTN3/TOMM40/VCP/CYC1/EIF2S1/PSMC2/PSMD6/NDUFS6/PSMA5/PSMD1/MT-ATP8/NDC1/PSMC6/ATF6/GPX8	11.373551152789
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	61/1085	138/9376	3.81978227476124	MT-CO3/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/COX6B1/COX5A/MT-CO2/NDUFS5/NDUFV2/NDUFA6/PPA1/NDUFC2/COX7A2/NDUFAB1/NDUFB2/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/NDUFA12/NDUFB9/NDUFB7/NDUFC1/TCIRG1/NDUFA3/NDUFB3/ATP6V1F/UQCRFS1/UQCRB/NDUFS8/COX17/COX8A/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/NDUFS3/NDUFB10/UQCRC1/NDUFS2/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/UQCRQ/COX7A2L/CYCS/PPA2/SDHC/NDUFA8/ATP6V1B1/CYC1/NDUFS6/MT-ATP8	12.0715542424368
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	75/1085	205/9376	3.16151511745532	GAPDH/MMP2/MT-CO3/CYBA/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/COL1A1/COX6B1/COX5A/MT-CO2/SLC2A1/COL3A1/NDUFS5/RAC1/NDUFV2/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/NDUFA12/PPP1CA/NDUFB9/NDUFB7/SLC25A6/TGFB1/NDUFC1/NDUFA3/AKT1/NDUFB3/UQCRFS1/UQCRB/PTEN/COL1A2/NDUFS8/COX8A/VDAC2/PARP1/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/NDUFS3/NDUFB10/UQCRC1/NDUFS2/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/UQCRQ/GYS1/COX7A2L/SDHC/NDUFA8/VDAC3/PDHB/CYC1/PRKCD/NDUFS6/MT-ATP8/SLC25A4	11.3194131290124
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	127/1085	480/9376	2.28639016897081	TUBA1C/TUBA1B/CALM1/TUBB/CALM3/HSPA5/RPS27A/MT-CO3/PSMA7/NDUFA4/MT-CO1/UQCRH/COX5B/APP/COX6C/TUBB6/UBA52/COX6B1/COX5A/MT-CO2/PSMB1/PARK7/NDUFS5/PSMA4/UBE2L3/RAC1/NDUFV2/HSD17B10/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/PSMB3/PSMB2/NDUFA12/NDUFB9/PSMB5/PSMB6/NDUFB7/SLC25A6/PSMA1/PSMD4/NDUFC1/PSMA3/NDUFA3/NDUFB3/UQCRFS1/UQCRB/TANK/NDUFS8/CALM2/COX8A/NRBF2/NOS2/CHMP2B/PSMB4/SNCA/VDAC2/PSMD2/WNT10B/ADRM1/PSMB7/UQCR10/UBA1/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/BAD/CSNK1E/NDUFS3/MAP2K2/NDUFB10/UQCRC1/PSMC3/LRP6/AXIN1/PSMD7/NDUFS2/GRIN2D/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/CAPN1/CSNK2B/PSMD11/KIF5B/PSMD14/UQCRQ/COX7A2L/WNT7A/CYCS/PSMD8/DKK1/PSMC5/SDHC/PSMD12/PSMC4/NDUFA8/VDAC3/DCTN3/HRAS/TOMM40/VCP/CYC1/EIF2S1/PSMC2/PSMD6/NDUFS6/PSMA5/PSMD1/MT-ATP8/PSMC6/ATF6/GPX8/SLC25A4	10.4662955350998
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	79/1085	235/9376	2.90500637317384	ACTB/RPS6/GRB2/MT-CO3/ACTG1/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/COX6B1/COX5A/MT-CO2/NDUFS5/NDUFV2/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/NDUFA12/NDUFB9/NDUFB7/NDUFC1/ACSL4/NDUFA3/NDUFB3/UQCRFS1/UQCRB/KDM1A/NDUFAF3/NDUFS8/COX16/COX17/COX8A/NDUFAF2/SMARCA2/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/NDUFS3/NDUFB10/COX20/UQCRC1/GNAS/NDUFAF1/NDUFS2/NDUFA11/MT-ND6/NDUFB6/PPARG/NDUFB1/NDUFAF4/COA4/NDUFA1/ADCY3/COA6/UQCRQ/COX7A2L/SDHC/ACTL6A/NDUFA8/ADCY5/HRAS/SMARCC1/CYC1/NDUFS6/COA3/CREB3/MT-ATP8	10.6986889044395
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	31/1085	46/9376	5.82360248447205	PSMA7/POMP/PSMB1/PSMA4/PSMB3/PSMB2/PSMB5/PSMB6/PSMA1/PSMD4/PSMA3/PSMB4/PSMD2/ADRM1/PSMB7/PSME1/PSMC3/PSMD7/PSMD11/PSMD14/PSME2/PSMD8/PSMC5/PSMD12/PSMC4/PSMF1/PSMC2/PSMD6/PSMA5/PSMD1/PSMC6	11.8633311639029
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	76/1085	227/9376	2.89318094155383	GRB2/MT-CO3/CYBA/NDUFA4/MGST3/MT-CO1/UQCRH/COX5B/COX6C/MGST1/COX6B1/COX5A/MT-CO2/NDUFS5/RAC1/NDUFV2/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/VDAC1/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/NDUFA12/NDUFB9/NDUFB7/SLC25A6/NDUFC1/ACP1/NDUFA3/AKT1/NDUFB3/SLC26A1/UQCRFS1/UQCRB/PTEN/NDUFS8/COX8A/VDAC2/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/BAD/NDUFS3/MAP2K2/NDUFB10/UQCRC1/GSTA4/NDUFS2/PRKD3/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/UQCRQ/GSTO1/CBR1/COX7A2L/SDHC/NDUFA8/VDAC3/HRAS/CYC1/PRKCD/NDUFS6/MT-ATP8/SLC25A4	10.4451646035351
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	60/1085	157/9376	3.30247439020811	LEP/MT-CO3/NDUFA4/MT-CO1/UQCRH/COX5B/COX6C/COX6B1/COX5A/MT-CO2/NDUFS5/RAC1/NDUFV2/CDC42/NDUFA6/NDUFC2/COX7A2/NDUFAB1/NDUFB2/COX7B/NDUFB4/NDUFB11/COX4I1/COX6A1/COX7C/NDUFA12/NDUFB9/NDUFB7/TGFB1/NDUFC1/NDUFA3/AKT1/NDUFB3/UQCRFS1/UQCRB/NDUFS8/COX8A/UQCR10/NDUFS4/NDUFV3/COX8C/NDUFA2/NDUFS7/NDUFS3/NDUFB10/UQCRC1/NDUFS2/NDUFA11/NDUFB6/PPARG/NDUFB1/NDUFA1/UQCRQ/COX7A2L/CYCS/SDHC/NDUFA8/CYC1/EIF2S1/NDUFS6	10.5244589082719
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	54/1085	174/9376	2.68183696170348	CALR/PDIA6/PDIA3/HSP90B1/HSPA5/SSR2/MAN1A2/OSTC/TUSC3/LMAN1/SSR4/PDIA4/SSR3/DNAJB11/LMAN2/ERP29/SIL1/CKAP4/P4HB/SEC61B/PRKCSH/EDEM2/DNAJC3/SEC61G/DAD1/TMEM258/CANX/KRTCAP2/DDOST/RBX1/HYOU1/DNAJC10/RPN1/RPN2/UBXN1/MAGT1/STT3B/ERLEC1/STT3A/DERL2/SEC62/RAD23A/BCAP31/GANAB/CAPN1/UGGT1/SEC61A1/VCP/SSR1/SEC23B/EIF2S1/SEL1L/ATF6/TRAM1	8.10054897635063
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	29/1085	87/9376	2.88049155145929	MT-CO3/TPM4/MT-CO1/UQCRH/COX5B/COX6C/COX6B1/COX5A/MT-CO2/MYL4/TPM2/COX7A2/COX7B/COX4I1/COX6A1/COX7C/TPM3/ATP1B3/UQCRFS1/UQCRB/COX8A/UQCR10/COX8C/UQCRC1/MYL3/UQCRQ/COX7A2L/SLC8A1/CYC1	6.37446265570269
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	38/1085	144/9376	2.28038914490527	PSMA7/PSMB1/PSMA4/VDAC1/PSMB3/PSMB2/PSMB5/PSMB6/SLC25A6/PSMA1/PSMD4/PSMA3/AKT1/NRBF2/PSMB4/VDAC2/PSMD2/ADRM1/PSMB7/NOP56/PSMC3/PSMD7/GRIN2D/PSMD11/PSMD14/CYCS/PSMD8/PSMC5/PSMD12/PSMC4/VDAC3/PSMC2/PSMD6/TBPL1/PSMA5/PSMD1/PSMC6/SLC25A4	5.6010878115928
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1085	31/9376	3.90260145681582	HSPA5/SRP14/SEC11A/SPCS3/SEC11C/SPCS1/SEC61B/SEC61G/SPCS2/SRP72/SRP19/SEC62/SEC61A1/TMEM208	5.85565731070884
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	41/1085	170/9376	2.08412035782055	ACTB/TUBA1C/TUBA1B/ACTG1/MYL12A/MYL6/ARPC3/ARPC5/MYL12B/ACTN1/JAM3/RAC1/CDC42/MYH9/ARPC1B/MYH10/ACTN4/CLDN6/PPP2R1A/ARPC1A/ACTR3/MYL9/ITGB1/CLDN7/RAB13/ERBB2/CLDN10/RHOA/ACTR2/F11R/VASP/ROCK1/MYL6B/MPDZ/HSPA4/ARPC4/ROCK2/ARPC5L/RAB8B/MSN/RAP2C	5.16016424151935
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	37/1085	149/9376	2.14586954504686	NDUFA4/NDUFS5/GNG5/NDUFV2/NDUFA6/NDUFC2/NDUFAB1/NDUFB2/NDUFB4/NDUFB11/NDUFA12/NDUFB9/NDUFB7/NDUFC1/GNAI1/NDUFA3/NDUFB3/NDUFS8/GNB2/GNAI3/NDUFS4/NDUFV3/NDUFA2/NDUFS7/NDUFS3/NDUFB10/NDUFS2/NDUFA11/MT-ND6/NDUFB6/NDUFB1/NDUFA1/GNG4/ADCY3/NDUFA8/ADCY5/NDUFS6	5.10029270034097
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/1085	78/9376	2.54812714167553	ACTB/ACTG1/ARPC3/ARPC5/CDH1/RAC1/CDC42/ARPC1B/ARPC1A/ACTR3/ITGB1/ELMO1/ITGA5/CLTA/VCL/RHOA/ACTR2/CAV1/SHC1/CTNNA1/ARPC4/ARPC5L/CRKL	4.96656592851439
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/1085	93/9376	2.32297705762846	ACTB/ACTG1/MYL12A/HEG1/CDH1/MYL12B/ACTN1/RAC1/CDC42/ACTN4/MYL9/ACP1/RAC3/ERBB2/VCL/RHOA/ARHGAP29/CTNND1/IQGAP1/ROCK1/CTNNA1/CSNK2B/SNAI1/PDCD10/ROCK2	4.6381699913878
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	29/1085	116/9376	2.16036866359447	ACTB/MMP2/CYBA/ACTG1/MYL12A/MYL12B/ACTN1/JAM3/RAC1/CDC42/ACTN4/ARHGAP5/CLDN6/MYL9/ITGB1/CLDN7/GNAI1/CLDN10/VCL/RHOA/GNAI3/F11R/CTNND1/VASP/ROCK1/CTNNA1/ROCK2/THY1/MSN	4.54900634842264
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/1085	116/9376	2.08587319243604	GAPDH/PKM/GPT2/PGK1/PFKP/ADH5/ENO1/TALDO1/ALDOA/TPI1/GCSH/MDH2/TKT/MDH1/PGLS/ACAT2/HK2/GPI/PGAM1/PFKM/HK1/IDH1/SDHC/PDHB/RPIA/ECHS1/ESD/SUCLG1	4.25696091332903
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/1085	203/9376	1.78789130780232	ACTB/GRB2/PGF/ACTG1/MYL12A/FLT4/LAMA4/COL1A1/TLN1/MYL12B/ACTN1/RAC1/CDC42/PPP1CA/ACTN4/FLNA/ARHGAP5/MYL9/ITGB1/COL9A3/AKT1/RAC3/PTEN/COL1A2/ITGAV/ERBB2/ITGA5/VCL/RHOA/COL6A3/CAV1/LAMB1/BAD/VASP/ROCK1/SHC1/CCND3/PAK4/ROCK2/HRAS/COL6A2/CRKL	4.10540192097673
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1085	56/9376	2.62330480579329	MAN1A2/OSTC/TUSC3/MGAT3/DAD1/TMEM258/KRTCAP2/DDOST/RPN1/RPN2/MAGT1/STT3B/SRD5A3/STT3A/MGAT1/GANAB/ALG9	4.40740724701177
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	19/1085	67/9376	2.45056743930119	GAPDH/LDHB/LDHA/PKM/PGK1/PFKP/ADH5/ENO1/ALDH2/ALDOA/TPI1/ALDH7A1/HK2/GPI/PGAM1/PFKM/HK1/ALDH1B1/PDHB	4.31043261942396
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/1085	59/9376	2.48991642583769	PRDX6/GSTP1/MGST3/MGST1/ODC1/RRM2/GPX4/SRM/TXNDC12/GSTA4/IDH1/GGCT/GSTO1/GCLM/SMS/LAP3/GPX8	4.15285641778122
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/1085	44/9376	2.74956011730205	MAN1A2/OSTC/TUSC3/DAD1/TMEM258/KRTCAP2/DDOST/RPN1/RPN2/MAGT1/STT3B/STT3A/MGAT1/ALG9	4.20789498687755
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1085	71/9376	2.31250730187577	SLC16A3/LDHB/LDHA/PKM/SLC2A1/PFKP/FGFR3/AKT1/PTEN/ERBB2/SLC7A5/MAP2K2/HK2/PGAM1/PFKM/HK1/IDH1/HRAS/PDHB	4.01577862307215
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1085	85/9376	2.13495256166983	RRM2/ADA/TYMP/NME1/APRT/GUK1/TYMS/DUT/TK1/HDDC2/ITPA/IMPDH2/IMPDH1/GMPS/DCTPP1/DTYMK/AK2/ADSL/AK5/AK1/NME2	3.80235789294832
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	46/1085	248/9376	1.60285416976364	ACTB/GAPDH/PFN1/TUBA1C/TUBA1B/TUBB/HSP90B1/ACTG1/MYL12A/RPS3/ARPC3/TUBB6/DYNLL1/ARPC5/MYL12B/CASP4/RAC1/ANXA2/CDC42/ARPC1B/TXN2/FLNA/TXN/ARPC1A/ACTR3/MYL9/ELMO1/AKT1/RHOA/ACTR2/PIK3C2G/MAP2K2/DYNC1LI1/SNX18/RALA/KIF5B/ARPC4/FBXO22/CYCS/ROCK2/ARPC5L/DCTN3/HRAS/GSDMD/RRAS/NCKAP1	3.48054572481983
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	43/1085	232/9376	1.60165262990625	ACTB/PFN1/ACTG1/MYL12A/ARPC3/ARPC5/CFL1/MYL12B/ACTN1/RAC1/CDC42/MYH9/ARPC1B/FGFR3/MYH10/PPP1CA/ACTN4/ARPC1A/ACTR3/MYL9/ITGB1/AKT1/RAC3/ITGAV/ITGA5/VCL/RHOA/ACTR2/MAP2K2/ENAH/IQGAP1/ROCK1/PAK4/ARPC4/ROCK2/ARPC5L/HRAS/DIAPH3/RRAS/CRKL/NCKAP1/MSN/CFL2	3.35674810854745
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/1085	142/9376	1.76480820406309	ACTB/MMP2/CALM1/CALM3/HSP90B1/CYBA/CTSL/ACTG1/GSTP1/MGST3/MGST1/SUMO2/RAC1/GPC1/TXN2/TXN/AKT1/RAC3/ITGAV/CALM2/RHOA/CAV1/GSTA4/SDC1/GSTO1/SUMO1/IL1R1/NPPC/THBD	3.32199385494349
Genetic Information Processing	Transcription	hsa03040	Spliceosome	44/1085	243/9376	1.56471146005196	RBM8A/SNRPD2/SNRPG/SNRPD1/HNRNPA1/SRSF9/SNRPB/SNRPF/LSM3/SNRPE/HNRNPM/LSM2/U2AF1/HNRNPA3/LSM5/SNRPD3/ALYREF/LSM4/MAGOH/THOC7/TXNL4A/MAGOHB/HNRNPK/LSM6/SNRPA1/SNRPB2/SF3B5/SNRPC/CWC15/PCBP1/PPIH/PRPF38B/HNRNPC/BCAS2/SF3B2/PRPF40A/THOC3/BUD31/NCBP2/PQBP1/ZMAT2/PLRG1/RBMX2/RBM17	3.22641374333188
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/1085	63/9376	2.19466022968327	CDK7/POLR2F/RBX1/POLR2I/RPA3/GTF2H5/POLR2J/RAD23A/POLE4/POLR2H/POLR2K/POLR2G/POLR2L/GTF2H3/POLD2/MNAT1	3.44165179675268
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/1085	75/9376	2.07395391705069	GAPDH/CBS/PKM/GPT2/PGK1/PFKP/ENO1/TALDO1/ALDOA/TPI1/TKT/PGAM1/PFKM/IDH1/ASL/RPIA/CTH/ARG2	3.37791335541753
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	45/1085	253/9376	1.537021183585	ACTB/PFN1/RPS27A/ACTG1/MYL12A/ARPC3/TLN1/UBA52/ARPC5/MYL12B/ACTN1/BNIP3/CASP4/RAC1/CDC42/PLCD4/VDAC1/ARPC1B/ACTN4/U2AF1/ARPC1A/ACTR3/MYL9/RBX1/ITGB1/ELMO1/AKT1/ITGA5/VCL/RHOA/UBE2N/ACTR2/HK2/ROCK1/HK1/CAPN1/ARPC4/CYCS/ROCK2/ARPC5L/IL1R1/PRKCD/CRKL/CAPNS1/BCL10	3.1324192937962
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1085	158/9376	1.69547920433996	CCNB1/CCNE1/CDK7/YWHAE/ANAPC11/YWHAB/PTTG1/TGFB1/PPP2R1A/RBX1/RAD21/CDKN1C/SMC1A/CDC20/SKP2/CCNB2/MAD2L1/YWHAQ/SMC3/E2F3/CCND3/CHEK1/CDK1/PRKDC/HDAC2/CDC14B/PPP2R5A/CDC45/TFDP1/ORC6/YWHAH	3.18927075066052
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/1085	212/9376	1.58970524302235	ACTB/PFN1/CALM1/CALM3/PGF/ACTG1/FLT4/TLN1/CDH1/RAC1/CDC42/EFNA1/FGFR3/SIPA1L2/ANGPT4/RALB/ITGB1/GNAI1/AKT1/RAC3/ID1/CALM2/RHOA/EFNA4/GNAI3/EPHA2/MAP2K2/CTNND1/GNAS/ENAH/PRKD3/VASP/RALA/ADCY3/ADCY5/HRAS/EFNA3/RRAS/CRKL	3.14164731473827
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	37/1085	200/9376	1.59867281105991	ACTB/GAPDH/TUBA1C/TUBA1B/TUBB/TMBIM6/ACTG1/MYO1B/RPS3/ARPC3/TMED10/TUBB6/NCL/ARPC5/CASP4/RAC1/CDC42/MYH9/ARPC1B/MYH10/MYO10/CLDN6/ARPC1A/ACTR3/ITGB1/CLDN7/MYO1E/CLDN10/RHOA/ACTR2/ROCK1/ARPC4/CYCS/ROCK2/ARPC5L/IL1R1/NCKAP1	3.09581414375983
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	40/1085	224/9376	1.54312047399605	HLA-G/CALR/HLA-C/RAN/TLN1/RANBP1/B2M/SLC2A1/CCNE1/ANAPC11/PTTG1/VDAC1/SLC25A6/TGFB1/CANX/AKT1/PTEN/CDC20/VDAC2/NFYB/CCNB2/HLA-E/MAD2L1/TSPO/STAT5B/MAP2K2/XPO1/E2F3/CCND3/JAK1/ADCY3/CHEK1/FDPS/VDAC3/ADCY5/HRAS/IL1R1/TBPL1/CREB3/SLC25A4	2.9761802327146
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/1085	51/9376	2.20272883346887	ACTB/ACTG1/PDIA4/SEC61B/KDELR1/SEC61G/KDELR2/TCIRG1/ATP6V1F/GNAS/ADCY3/SEC61A1/ATP6V1B1	3.11548338959681
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1085	47/9376	2.20633395430925	LDHB/LDHA/PKM/ADH5/ALDH2/MDH2/ALDH7A1/MDH1/ACAT2/GLO1/ALDH1B1/PDHB	2.99913478598408
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	40/1085	233/9376	1.48351496212496	ACTB/DSC2/TPM4/ACTG1/DSP/COL1A1/TLN1/DSG2/MYL4/COL3A1/LMNB2/TPM2/NID1/MYH9/ENO1/CAPZB/FLNC/MYH10/SPTBN1/TPM3/MYL9/ATP1B3/ITGB1/COL9A3/COL1A2/ITGAV/ITGA5/VCL/CSRP1/SGCB/DAG1/COL6A3/LMNB1/LBR/MYL3/SDC1/DCN/DIAPH3/PDLIM2/COL6A2	2.70358836018143
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/1085	110/9376	1.72829493087558	GAPDH/RPS6/TIMP1/LDHB/LDHA/SLC2A1/PGK1/PFKP/ENO1/ALDOA/ANGPT4/RBX1/AKT1/ERBB2/NOS2/EIF4EBP1/MAP2K2/HK2/PFKM/HK1/EGLN1/PDHB	2.77942226082842
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/1085	78/9376	1.883398322108	PFKP/ENO1/LSM3/HSPD1/LSM2/LSM5/LSM4/LSM6/C1D/PFKM/DCPS/EXOSC3/HSPA9/EXOSC7/EXOSC8/XRN2/EXOSC5	2.83404113898543
NA	NA	hsa04518	Integrin signaling	28/1085	154/9376	1.57117720988689	ACTB/PGF/ACTG1/FLT4/LAMA4/COL1A1/TLN1/CDH1/ACTN1/FERMT2/RAC1/CDC42/ACTN4/FLNA/TGFB1/ITGB1/COL9A3/AKT1/RAC3/COL1A2/ITGAV/ERBB2/ITGA5/VCL/COL6A3/LAMB1/CCND3/COL6A2	2.58532842908869
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1085	50/9376	2.07395391705069	ODC1/ALDH2/SRM/ALDH7A1/P4HA2/NOS2/CKMT1A/ALDH1B1/SMS/LAP3/ARG2/CKMT1B	2.7543554967704
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/1085	205/9376	1.47537372147915	HLA-G/CALR/HLA-C/PDIA3/B2M/CCNE1/RAC1/ISG15/TAP1/PSMD4/AKT1/PSMD2/SKP2/ADRM1/HLA-E/PSMC3/PSMD7/E2F3/CCND3/JAK1/PSMD11/IFNAR1/PSMD14/CYCS/IRF7/PSMD8/PSMC5/PSMD12/PSMC4/HDAC2/PSMC2/PSMD6/PSMD1/PSMC6/IFNAR2	2.48943507294708
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	28/1085	157/9376	1.54115471543045	HLA-G/HLA-C/CALM1/CALM3/CCNB1/CCNE1/VDAC1/PPP1CA/SLC25A6/TGFB1/AKT1/PTEN/CALM2/VDAC2/EIF4EBP1/CCNB2/HLA-E/MAP2K2/E2F3/CCND3/CAPN1/CHEK1/CDK1/VDAC3/HRAS/RRAS/MYBL2/SLC25A4	2.47358259001116
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	41/1085	250/9376	1.41720184331797	HLA-G/HLA-C/ARPC3/RAB11A/ARPC5/CDC42/CAPZB/CBLB/ARPC1B/FGFR3/CHMP2A/ARPC1A/ACTR3/SNX6/CLTA/CHMP2B/RHOA/AP2M1/ACTR2/EPN1/CAV1/HLA-E/SNX3/SNF8/EEA1/RAB10/ARF5/VPS29/GRK5/VPS25/KIF5B/ARPC4/SNX2/ARPC5L/HRAS/CHMP1B/VPS28/CHMP4B/CHMP5/VPS35/VPS26A	2.41865007668648
Cellular Processes	Cell motility	hsa04814	Motor proteins	33/1085	194/9376	1.46994156491995	ACTB/TUBA1C/TUBA1B/TUBB/TPM4/ACTG1/MYL12A/MYL6/MYO1B/TUBB6/DYNLL1/MYL12B/MYL4/TPM2/CENPE/MYH9/CAPZB/MYH10/MYO10/TPM3/MYL9/MYO1E/KIFAP3/DYNC1LI1/ACTA2/MYL6B/MYL3/KIF5B/DCTN3/KIF2A/MYO7A/TUBG1/KIF20B	2.39261669742913
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/1085	138/9376	1.56548453883657	CALM1/CALM3/CCNB1/CCNE1/YWHAE/ANAPC11/YWHAB/PTTG1/PPP1CA/PPP2R1A/RBX1/CALM2/SMC1A/CDC20/CCNB2/MAD2L1/YWHAQ/SMC3/ADCY3/CDK1/AURKA/ADCY5/PPP2R5A/SLK/YWHAH	2.42085261153827
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	34/1085	204/9376	1.44024577572965	ACTB/MMP2/RPS6/GRB2/CTSL/ACTG1/CD63/COL1A1/RAC1/CDC42/GPC1/PPP1CA/FLNA/TGFB1/ITGB1/AKT1/COL1A2/ITGAV/ERBB2/ITGA5/WNT10B/RHOA/CAV1/MAP2K2/IQGAP1/ROCK1/SDC1/WNT7A/DCN/ROCK2/LUM/HRAS/RRAS/MSN	2.29972183074649
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/1085	54/9376	1.92032770097286	LDHB/CBS/LDHA/MDH2/SRM/MDH1/ADI1/CISD1/GCLM/SMS/CTH/AHCY	2.45347634092535
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	34/1085	205/9376	1.43322018657975	HLA-G/HLA-C/GRB2/RANBP1/PKM/ACTN1/CCNE1/RAC1/YWHAE/CDC42/YWHAB/ACTN4/CDC20/HNRNPK/SKP2/RHOA/GTF2A2/HLA-E/YWHAQ/BAD/STAT5B/CCND3/JAK1/CHEK1/CDK1/IRF7/MRPS18B/VDAC3/GTF2H3/HDAC2/HRAS/TBPL1/CREB3/YWHAH	2.26868562154544
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/1085	155/9376	1.50528913334324	HLA-G/CALR/ACTB/HLA-C/TUBA1C/TUBA1B/TUBB/CYBA/CTSL/ACTG1/TUBB6/RAC1/SEC61B/SEC61G/TAP1/CANX/ITGB1/TCIRG1/ATP6V1F/ITGAV/ITGA5/HLA-E/EEA1/DYNC1LI1/C1R/SEC61A1/ATP6V1B1	2.2946362294578
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1085	31/9376	2.23005797532332	PFKP/TALDO1/ALDOA/TKT/PGLS/GPI/PFKM/RPIA	2.48149740257461
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1085	37/9376	2.10198032133516	CMAS/GNPNAT1/UGP2/HK2/GPI/UXS1/HK1/GALK1/UAP1L1	2.42952606769228
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1085	82/9376	1.68614139597617	GSTP1/MGST3/MGST1/RRM2/TYMP/NME1/DUT/TK1/ITPA/IMPDH2/GSTA4/UMPS/IMPDH1/GSTO1/GMPS/NME2	2.25744024688136
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/1085	82/9376	1.68614139597617	HLA-G/CALR/HLA-C/PDIA3/HSPA5/HSPA2/CTSL/B2M/TAP1/CANX/NFYB/HLA-E/PSME1/HSPA4/PSME2/RFXANK	2.25744024688136
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/1085	227/9376	1.37045413020971	HLA-G/CALR/HLA-C/PDIA3/CALM1/CALM3/GRB2/B2M/GNG5/RAC1/TAP1/GNAI1/AKT1/RAC3/ITGAV/GNB2/CALM2/RHOA/EIF4EBP1/GNAI3/HLA-E/MAP2K2/GNAS/ROCK1/E2F3/GNG4/JAK1/ADCY3/CYCS/ROCK2/ADCY5/CCR1/HRAS/IL1R1/CRKL/CREB3	2.04389040855438
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1085	27/9376	2.24038231780167	SCD/HSD17B12/HSD17B4/ELOVL2/ELOVL6/SCP2/ELOVL1	2.33481200921743
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/1085	98/9376	1.58720963039594	ARPC3/ARPC5/CFL1/RAC1/CDC42/ARPC1B/MYO10/ARPC1A/ACTR3/AKT1/ACTR2/VASP/GAB2/ARPC4/ARPC5L/PRKCD/CRKL/CFL2	2.1138592805693
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1085	128/9376	1.4852534562212	PDE4D/RRM2/ADA/NME1/APRT/GUK1/PAICS/HDDC2/ITPA/IMPDH2/IMPDH1/ADCY3/PDE6H/ADCY5/GMPS/AK2/PAPSS1/ADSL/GART/AK5/AK1/NME2	1.99961672851241
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1085	34/9376	2.03328815397127	POLR2F/POLR1D/POLR2I/POLR2J/POLR2H/POLR2K/POLR2G/POLR2L	2.18342373623148
NA	NA	hsa04517	IgSF CAM signaling	45/1085	299/9376	1.30055638611038	ACTB/TUBA1C/TUBA1B/TUBB/GRB2/ACTG1/MYL12A/MYL6/ARPC3/APP/TUBB6/DYNLL1/ARPC5/CDH1/MYL12B/ACTN1/JAM3/RAC1/CDC42/MYH9/ARPC1B/MYH10/ACTN4/SPTBN1/ARPC1A/ACTR3/MYL9/ITGB1/AKT1/ITGA5/VCL/RHOA/ACTR2/F11R/MAP2K2/IQGAP1/MYL6B/PAK4/MPDZ/ARPC4/ROBO1/ARPC5L/NLGN2/PLXNA1/MSN	1.91067770622444
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	19/1085	108/9376	1.52025942993685	RAN/RBM8A/SUMO2/SAP18/ALYREF/EEF1A1/KPNA2/MAGOH/THOC7/MAGOHB/KPNB1/NUP37/PHAX/XPO1/THOC3/UPF3B/SUMO1/NCBP2/NDC1	1.96714274571634
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/1085	75/9376	1.6130752688172	PERP/CCNB1/CCNE1/RRM2/SIVA1/PTEN/EI24/CCNB2/CCND3/SHISA5/CHEK1/CDK1/CYCS/CCNG2	1.92830912531238
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1085	36/9376	1.92032770097286	PYGL/UGP2/GYG2/HK2/GPI/HK1/GYS1/GBE1	2.00132378141156
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	33/1085	214/9376	1.33256384857229	HLA-G/CALR/HLA-C/PDIA3/CALM1/CALM3/CFL1/CCNB1/B2M/GNG5/RAC1/TAP1/RBX1/GNAI1/AKT1/RAC3/GNB2/CALM2/RNF7/CCNB2/GNAI3/HLA-E/BAD/MAP2K2/GNG4/PAK4/CHEK1/CDK1/CYCS/HRAS/AP1M2/CRKL/CFL2	1.78026162367556
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1085	70/9376	1.60484529295589	GRB2/SLC2A1/RAC1/CDC42/TGFB1/RBX1/AKT1/BAD/MAP2K2/EGLN1/PAK4/HRAS/CRKL	1.83742174124022
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/1085	70/9376	1.60484529295589	HLA-G/ACTB/HLA-C/ACTG1/CD55/RAC1/EIF4G1/RAC3/SGCB/DAG1/CAV1/HLA-E/CYCS	1.83742174124022
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1085	44/9376	1.76757436112275	CDK7/TAF10/TAF9/GTF2H5/GTF2A2/GTF2H3/GTF2F2/TBPL1/MNAT1	1.8461053577312
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1085	38/9376	1.81925782197429	GNPNAT1/UGP2/HK2/GPI/UXS1/HK1/GALK1/UAP1L1	1.83055385253706
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/1085	166/9376	1.35348398201099	CALM1/CALM3/VDAC1/ATP2B4/PPP1CA/SLC25A6/MYL9/ATP1B3/GNAI1/AKT1/CALM2/VDAC2/RHOA/GNAI3/BAD/MAP2K2/VASP/ROCK1/ADCY3/ROCK2/VDAC3/ADCY5/SLC8A1/NPPC/CREB3/SLC25A4	1.66222962155858
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1085	32/9376	1.89032258064516	PFKP/UGP2/AKR1B1/HK2/PFKM/HK1/GALK1	1.82495858103257
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1085	14/9376	2.46899275839368	ST3GAL1/B3GNT2/B4GALT4/B3GNT7	1.98974033597801
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1085	130/9376	1.39593052109181	MMP2/GRB2/COL1A1/COL3A1/GNG5/TGFB1/GNAI1/AKT1/COL1A2/GNB2/NOS2/GNAI3/MAP2K2/GNAS/ACTA2/SHC1/GNG4/ADCY3/ADCY5/HRAS/CREB3	1.6444124750431
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1085	59/9376	1.6111223931891	RRM2/TYMP/NME1/TYMS/DUT/TK1/HDDC2/UMPS/DCTPP1/DTYMK/NME2	1.70338651792381
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/1085	138/9376	1.37762639417618	ACTB/ACTG1/ARPC3/ARPC5/RAC1/CDC42/ARPC1B/ARPC1A/ACTR3/ITGB1/ELMO1/AKT1/RAC3/ITGA5/RHOA/ACTR2/MAP2K2/ROCK1/ARPC4/ROCK2/ARPC5L/CRKL	1.61662747563006
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1085	39/9376	1.77261018551341	CBS/GCSH/ALDH7A1/MTHFD1L/TYMS/CTH/GART/AHCY	1.74898507361156
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	28/1085	184/9376	1.31500701262272	MYL12A/CFL1/MYL12B/RAC1/CDC42/EFNA1/SEMA4B/MYL9/ITGB1/GNAI1/SEMA7A/RAC3/FES/RHOA/EFNA4/GNAI3/EPHA2/ENAH/EPHB3/ROCK1/PAK4/ROBO1/ROCK2/HRAS/EFNA3/RRAS/PLXNA1/CFL2	1.56106567849827
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/1085	125/9376	1.38263594470046	RAC1/PPP2R1A/GNAI1/AKT1/ORMDL2/RAC3/PTEN/RHOA/GNAI3/MAP2K2/ROCK1/CERS5/GAB2/ROCK2/SGPL1/HRAS/PPP2R5A/DEGS1/SPTLC1/SGPP1	1.5579140027801
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/1085	140/9376	1.35794601711652	RPS6/CALM1/CALM3/CDH1/MYL4/GNG5/GNAI1/AKT1/GNB2/CALM2/NOS2/GNAI3/MAP2K2/ACTA2/GNG4/MYL3/ADCY3/ADCY5/HRAS/SLC8A1/TFAM/RRAS	1.54360664614755
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1085	15/9376	2.30439324116743	ACP1/AK2/AK5/AK1	1.82890057489752
Organismal Systems	Immune system	hsa04611	Platelet activation	20/1085	126/9376	1.37166264355204	ACTB/ACTG1/MYL12A/COL1A1/TLN1/MYL12B/COL3A1/PPP1CA/ITGB1/GNAI1/AKT1/COL1A2/RHOA/GNAI3/GNAS/VASP/ROCK1/ADCY3/ROCK2/ADCY5	1.51935887669755
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/1085	134/9376	1.35426095329803	CALM1/CALM3/MYL6/MYH9/MYH10/PPP1CA/MYL9/PLA2G2A/CALM2/RHOA/PLA2G10/MAP2K2/GNAS/ACTA2/ROCK1/MYL6B/ADCY3/ROCK2/ADCY5/NPPC/PRKCD	1.4941347061475
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1085	41/9376	1.68614139597617	MMP2/CDH1/FGFR3/TYMP/ERBB2/MAP2K2/E2F3/HRAS	1.59274202318751
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1085	48/9376	1.62027649769585	CD63/CLDN6/CLDN7/CLDN10/TGOLN2/CD81/CHMP1B/EPCAM/CHMP4B	1.55850688695222
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1085	28/9376	1.85174456879526	GGH/AKR1B1/GCH1/CBR1/MOCOS/PTS	1.63277403886162
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1085	10/9376	2.59244239631336	SELENBP1/ETHE1/PAPSS1	1.82256784751284
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1085	35/9376	1.72829493087558	PFKP/ALDOA/TPI1/AKR1B1/HK2/PFKM/HK1	1.56149886544339
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1085	107/9376	1.3729445712563	CALM1/CALM3/LDHB/LDHA/PKM/SLC2A1/PFKP/PYGL/AKT1/CALM2/GNAS/PGAM1/PFKM/PRMT1/GYS1/PDHB/CREB3	1.40351412336652
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1085	57/9376	1.51604818497858	ACSL4/SCD/HSD17B12/HSD17B4/ELOVL2/ACAT2/ELOVL6/SCP2/ECHS1/ELOVL1	1.41364407282024
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1085	17/9376	2.03328815397127	TXNRD1/CTH/SEPHS1/PAPSS1	1.54251088454222
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1085	30/9376	1.72829493087558	MDH2/MDH1/IDH1/SDHC/PDHB/SUCLG1	1.4452802762403
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/1085	87/9376	1.39058212829069	GRB2/RAC1/RALB/TGFB1/BIRC5/AKT1/RAC3/RHOA/BAD/MAP2K2/AXIN1/RALA/CYCS/HRAS	1.32398956477194
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1085	37/9376	1.63487358326068	CDH1/TPM3/MAP2K2/PPARG/NCOA4/HRAS/CCDC6	1.39970005848399
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/1085	156/9376	1.27406357083776	GRB2/EIF3E/YWHAE/YWHAB/CLDN6/PPP2R1A/CLDN7/AKT1/CLDN10/YWHAQ/BAD/MAP2K2/E2F3/JAK1/MX1/IFNAR1/CYCS/CD81/IRF7/HRAS/EIF2S1/YWHAH/IFNAR2	1.24866287721462
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/1085	250/9376	1.2098064516129	CTSL/CD63/CTSV/TCIRG1/NPC2/AP5B1/LITAF/LAPTM4B/ATP6V1F/GM2A/LAMTOR5/LAMTOR1/CLN5/CLTA/DNASE2/AP2M1/GALC/CTSE/CD164/VPS29/HYAL3/BLOC1S4/LAMTOR2/CTSC/OSBPL6/AP3M2/AP3D1/FUCA2/IDUA/AP1M2/HYAL2/ATP6V1B1/OSBPL1A/VPS35/VPS26A	1.21631387399243
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1085	24/9376	1.80030721966206	HS3ST1/HS6ST1/HS3ST3B1/B4GALT7/EXTL2	1.42006150987911
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1085	59/9376	1.464656721081	GRB2/CDH1/AKT1/PTEN/ERBB2/BAD/MAP2K2/AXIN1/CTNNA1/HRAS	1.29514153461424
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1085	52/9376	1.49563984402694	PLTP/VDAC1/NPC2/LRPAP1/VDAC2/STARD3NL/TSPO/VDAC3/VAPA	1.29647396737199
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/1085	89/9376	1.35933309169989	LAMA4/COL1A1/ITGB1/COL9A3/COL1A2/ITGAV/ITGA5/DAG1/COL6A3/LAMB1/SDC1/CD47/HMMR/COL6A2	1.23211584989456
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/1085	105/9376	1.31679613780996	RPS27A/TOMM20/UBA52/BNIP3/PHB2/TOMM7/FKBP8/MTX1/CSNK2B/MTX2/HRAS/USP15/TOMM40/VCP/EIF2S1/RRAS	1.18088685149099
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1085	105/9376	1.31679613780996	ACTB/TPM4/ACTG1/TPM2/TPM3/TGFB1/ITGB1/ITGAV/ITGA5/SGCB/DAG1/GNAS/MYL3/ADCY3/ADCY5/SLC8A1	1.18088685149099
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/1085	75/9376	1.38263594470046	GSTP1/MGST3/MGST1/BIRC5/AKT1/ERBB2/BAD/GSTA4/TOP2A/GSTO1/CYCS/BRCA1	1.20350701025981
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1085	75/9376	1.38263594470046	CGA/HSP90B1/HSPA5/PDIA4/CANX/ATP1B3/GNAS/ADCY3/TTF1/ADCY5/CREB3/GPX8	1.20350701025981
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1085	138/9376	1.25238763106926	RPS6/CALM1/CALM3/GRB2/PYGL/CBLB/PPP1CA/PPP1R3B/SH2B2/AKT1/CALM2/EIF4EBP1/BAD/MAP2K2/HK2/SHC1/HK1/GYS1/HRAS/CRKL	1.08047738502458
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	22/1085	154/9376	1.23449637919684	ALAS2/ALDH2/NME1/MTHFD1L/UGP2/GGH/UROS/VKORC1/GCH1/UMPS/ALDH1B1/GCLM/UROD/HMBS/ALAD/AK2/PTS/ADSL/AK5/AK1/VKORC1L1/NME2	1.06140466594599
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/1085	154/9376	1.23449637919684	CALM1/CALM3/TPM4/MYL4/TPM2/ATP2B4/PPP1CA/TPM3/PPP2R1A/ATP1B3/GNAI1/AKT1/CALM2/GNAI3/GNAS/CREM/MYL3/ADCY3/ADCY5/SLC8A1/PPP2R5A/CREB3	1.06140466594599
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1085	77/9376	1.34672332276019	RALBP1/RAC1/CDC42/RALB/TGFB1/AKT1/RAC3/ERBB2/BAD/RALA/E2F3/JAK1	1.10511467095676
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1085	77/9376	1.34672332276019	GRB2/TGFB1/AKT1/BAD/STAT5B/MAP2K2/SHC1/E2F3/GAB2/HDAC2/HRAS/CRKL	1.10511467095676
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	24/1085	170/9376	1.21997289238276	ACTB/GRB2/ACTG1/GSTP1/MGST3/MGST1/TGFB1/AKT1/PTEN/WNT10B/SMARCA2/BAD/MAP2K2/LRP6/AXIN1/GSTA4/TXNRD1/SHC1/E2F3/GSTO1/WNT7A/ACTL6A/HRAS/SMARCC1	1.04702051316427
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/1085	93/9376	1.30086715227194	CGA/MMP2/CALM1/MMP14/CALM3/GRB2/CDC42/CALM2/MAP2K2/GNAS/ADCY3/ADCY5/HRAS/PRKCD	1.05479757869989
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/1085	93/9376	1.30086715227194	LAMA4/CCNE1/CKS1B/ITGB1/AKT1/PTEN/ITGAV/NOS2/SKP2/LAMB1/E2F3/CYCS/CKS2/TRAF4	1.05479757869989
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1085	13/9376	1.99418645870259	XRCC5/XRCC6/PRKDC	1.29756480634897
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/1085	78/9376	1.32945763913506	CALM1/CALM3/CFL1/ITGB1/GNAI1/ITGA5/CALM2/NOS2/RHOA/GNAI3/C1R/CFL2	1.05693714771129
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	44/1085	333/9376	1.14181647084873	HLA-G/HLA-C/GRB2/LAMA4/COL1A1/PKM/CCNE1/ISG15/CDC42/PPP2R1A/ITGB1/TCIRG1/COL9A3/AKT1/ATP6V1F/PTEN/COL1A2/ITGAV/ITGA5/WNT10B/EIF4EBP1/COL6A3/HLA-E/LAMB1/BAD/MAML3/MAP2K2/AXIN1/GNAS/CCND3/BCAP31/JAK1/MX1/IFNAR1/WNT7A/HDAC2/HRAS/PPP2R5A/ATP6V1B1/COL6A2/TBPL1/TUBG1/CREB3/IFNAR2	0.953212161563772
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1085	20/9376	1.72829493087558	CMAS/UGP2/CYB5R3/UAP1L1	1.17943558856856
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	32/1085	238/9376	1.16187894512644	RALBP1/CALM1/CALM3/GRB2/PGF/FLT4/GNG5/RAC1/CDC42/EFNA1/FGFR3/ANGPT4/RALB/PLA2G2A/AKT1/RAC3/GNB2/CALM2/RHOA/PLA2G10/EFNA4/EPHA2/BAD/MAP2K2/RALA/SHC1/GNG4/PAK4/GAB2/HRAS/EFNA3/RRAS	0.91506157099533
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1085	42/9376	1.44024577572965	GPX4/ACSL4/VDAC2/PCBP1/NCOA4/GCLM/VDAC3	1.03438685797487
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1085	80/9376	1.29622119815668	RPS6/GRB2/FGFR3/AKT1/PTEN/ERBB2/EIF4EBP1/BAD/MAP2K2/SHC1/JAK1/HRAS	0.962520792427379
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1085	50/9376	1.38263594470046	HBA2/HBA1/GYPC/GYPA/GYPB/TGFB1/SDC1/CD81	0.981341378633758
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1085	28/9376	1.54312047399605	HSD17B12/ELOVL2/ELOVL6/ECHS1/ELOVL1	1.04114900452994
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	47/1085	362/9376	1.12195941645238	RPS6/HSP90B1/GRB2/PGF/FLT4/LAMA4/COL1A1/CCNE1/GNG5/RAC1/YWHAE/YWHAB/EFNA1/FGFR3/ANGPT4/PPP2R1A/ITGB1/COL9A3/AKT1/PTEN/COL1A2/ITGAV/ERBB2/GNB2/ITGA5/EIF4EBP1/EFNA4/COL6A3/LAMB1/YWHAQ/CDC37/EPHA2/BAD/MAP2K2/CCND3/GNG4/JAK1/IFNAR1/GYS1/HRAS/EFNA3/PPP2R5A/COL6A2/BRCA1/CREB3/YWHAH/IFNAR2	0.856067275561078
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1085	21/9376	1.64599517226245	CHSY1/DSEL/CSGALNACT1/B4GALT7	1.07204761147391
NA	NA	hsa04519	Cadherin signaling	52/1085	404/9376	1.11226901491993	ACTB/DSC2/ACTG1/DSP/MYO1B/ARPC3/FLT4/ARPC5/CDH1/TMC6/ACTN1/DSG2/RAC1/YWHAE/CDC42/YWHAB/ARPC1B/PPP1CA/ACTN4/LIMA1/ARPC1A/ACTR3/RAC3/MYO1E/ERBB2/VCL/WNT10B/RHOA/ACTR2/KRT10/YWHAQ/MAP2K2/CTNND1/LRP6/AXIN1/ENAH/PSENEN/VASP/ROCK1/CTNNA1/TAOK3/MPDZ/ARPC4/WNT7A/ROCK2/ARPC5L/HRAS/RRAS/NCKAP1/PKP3/MYO7A/YWHAH	0.834455174061714
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1085	43/9376	1.40675168792198	ADH5/ALDH2/ACSL4/ALDH7A1/ACAT2/ALDH1B1/ECHS1	0.967052402982631
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1085	89/9376	1.26223787086418	TUBA1C/TUBA1B/TUBB/GRB2/TUBB6/GNAI1/GNAI3/MAP2K2/GNAS/ADCY3/CDK1/ADCY5/HRAS	0.899186422285364
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/1085	193/9376	1.16413648193692	GRB2/GNG5/RAC1/CDC42/ELMO1/GNAI1/AKT1/RAC3/CXCL14/GNB2/RHOA/GNAI3/BAD/STAT5B/ROCK1/SHC1/GRK5/GNG4/ADCY3/ROCK2/ADCY5/CCR1/HRAS/PRKCD/CCR7/CRKL	0.833467236982295
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1085	36/9376	1.44024577572965	SSBP1/RPA3/RNASEH2C/RNASEH2A/POLE4/POLD2	0.957348496304472
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/1085	137/9376	1.19845268929328	ACTB/TUBA1C/TUBA1B/CTSL/ACTG1/LMNB2/CTSV/BIRC5/AKT1/PARP1/BAD/MAP2K2/LMNB1/CASP6/CTSC/CAPN1/CYCS/HRAS/EIF2S1	0.84645103095271
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1085	44/9376	1.37478005865103	HMGB1/APEX1/PARP1/POLE4/POLD2/SMUG1/NTHL1	0.901389506072664
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/1085	139/9376	1.18120876570633	MMP2/CALM1/CALM3/HSP90B1/GRB2/GNAI1/AKT1/CALM2/GNAI3/KRT10/MAP2K2/GNAS/SHC1/ADCY3/GREB1/ADCY5/HRAS/PRKCD/CREB3	0.778606778320778
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1085	76/9376	1.25073975260732	ACTB/CALM1/CALM3/ACTG1/ATP1B3/GNAI1/CALM2/GNAI3/GNAS/ADCY3/ADCY5	0.793936127421763
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1085	53/9376	1.30437353273628	RAB11A/ATP2B4/ATP1B3/CLTA/AP2M1/PTH1R/GNAS/SLC8A1	0.803829660933936
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/1085	157/9376	1.15586603657284	CALR/BSG/ODC1/SLC2A1/RAC1/ATP11A/TGFB1/ELMO1/UQCRFS1/ATP11B/ITGAV/ADAM9/MAP2K2/PPARG/RAB17/SLC16A1/ATP11C/CD47/CRKL/ARG2/TMEM30B	0.712453395391627
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1085	23/9376	1.50286515728311	GPT2/NOS2/ASL/ARG2	0.873447981750479
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/1085	117/9376	1.18174012367561	ACTB/ACTG1/RUVBL1/SMARCA2/GATAD2A/SMARCA5/MORF4L1/YY1/BAZ1A/CDK2AP2/ACTL6A/HDAC2/SMARCC1/TFPT/RUVBL2/INO80C	0.715580929273821
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/1085	142/9376	1.15625365093789	RPS27A/UBA52/UBE2L3/ANAPC11/CBLB/RBX1/UBE2F/UBE2C/CDC20/RNF7/SKP2/UBE2N/UBE2E3/UBA1/FBXW7/UBE2M/HERC3/UBE2Q2/BRCA1	0.678697829691851
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1085	86/9376	1.20578716107598	GRB2/CBLB/AKT1/ERBB2/EIF4EBP1/BAD/STAT5B/MAP2K2/SHC1/PAK4/HRAS/CRKL	0.693516334078602
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1085	86/9376	1.20578716107598	ACTB/DSC2/ACTG1/DSP/DSG2/ITGB1/ITGAV/ITGA5/SGCB/DAG1/CTNNA1/SLC8A1	0.693516334078602
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/1085	120/9376	1.15219662058372	CALM1/CALM3/GRB2/RAC1/YWHAE/CDC42/SH2B2/AKT1/CALM2/RHOA/BAD/MAP2K2/SHC1/HRAS/PRKCD/CRKL	0.606989263259207
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1085	17/9376	1.52496611547845	MYH9/MYH10/DAG1	0.783678728948123
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/1085	73/9376	1.18376365128464	RAN/PPIA/FURIN/PSIP1/XPO1/MX1/MAP1B/NELFE/CHMP4B/PIN1	0.570172911923244
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1085	41/9376	1.26460604698213	CBS/ALAS2/GCSH/ALDH7A1/PGAM1/CTH	0.614230788419887
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1085	99/9376	1.13473909602942	ACTB/TPM4/ACTG1/TPM2/TPM3/TGFB1/ITGB1/ITGAV/ITGA5/SGCB/DAG1/MYL3/SLC8A1	0.48753353952633
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1085	19/9376	1.36444336648072	HYAL3/IDUA/HYAL2	0.575222129000771
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/1085	76/9376	1.13703613873393	CALM1/CALM3/GRB2/AKT1/PTEN/CALM2/MAP2K2/SHC1/E2F3/HRAS	0.433907827426288
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1085	101/9376	1.11226901491993	CALM1/CALM3/GNAI1/CALM2/WNT10B/GNAI3/MAP2K2/GNAS/ADCY3/WNT7A/ADCY5/HRAS/CREB3	0.410355907105473
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/1085	101/9376	1.11226901491993	MMP2/COL1A1/COL3A1/RAC1/CDC42/PLCD4/TGFB1/AKT1/COL1A2/STAT5B/HRAS/PRKCD/THBD	0.410355907105473
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1085	44/9376	1.17838290741517	RAB11A/DYNLL1/GNAS/DYNC1LI1/ADCY3/CREB3	0.429031580243394
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1085	69/9376	1.12714886796233	CALM1/CALM3/PPP1CA/CALM2/GNAS/GRIN2D/HDAC2/ADCY5/CREB3	0.38346809505091
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1085	36/9376	1.20020481310804	GALNT2/GALNT1/ST3GAL1/GCNT1/C1GALT1C1	0.435360853750929
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1085	28/9376	1.23449637919684	B3GNT2/B4GALT4/B3GNT5/ST3GAL4	0.44952397019826
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1085	12/9376	1.44024577572965	VKORC1/VKORC1L1	0.552016637987586
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/1085	103/9376	1.09067155831954	LAMA4/COL1A1/ACTN1/COL3A1/ACTN4/TGFB1/COL1A2/NOS2/VCL/LAMB1/GNAS/IL1R1/ARG2	0.334716107179812
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	19/1085	154/9376	1.06615596385182	ACTB/CALM1/CALM3/ACTG1/MYL6/PPP1CA/MYL9/GNAI1/CALM2/RHOA/GNAI3/MAP2K2/GNAS/ROCK1/MYL6B/ADCY3/ROCK2/ADCY5/HRAS	0.299442784374635
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/1085	122/9376	1.06247639193171	ACTB/ACTG1/SLC2A1/PFKP/PLCD4/ATP1B3/AKT1/ITGAV/BAD/MAP2K2/PFKM/MED30/SLC16A2/HDAC2/HRAS	0.251262778623677
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1085	46/9376	1.12714886796233	BLVRB/ALAS2/UROS/UROD/HMBS/ALAD	0.312714228133085
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1085	63/9376	1.09733011484164	ALDH2/PLOD1/ALDH7A1/ACAT2/COLGALT1/ALDH1B1/ECHS1/SUV39H2	0.280394673146246
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/1085	97/9376	1.06904841085087	CALM1/CALM3/GNG5/GNAI1/GNB2/CALM2/GNAI3/GNAS/GRIN2D/GNG4/ADCY3/ADCY5	0.247278306192338
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/1085	157/9376	1.04578355689923	ACTB/ACTG1/CDH1/YWHAE/YWHAB/PPP1CA/TGFB1/PPP2R1A/BIRC5/ID1/WNT10B/YWHAQ/CSNK1E/AXIN1/CCND3/CTNNA1/WNT7A/RASSF6/YWHAH	0.209273625500332
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1085	55/9376	1.09982404692082	GM2A/GALC/CERS5/SGPL1/DEGS1/SPTLC1/SGPP1	0.268585345382012
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/1085	106/9376	1.05980349534823	HSP90B1/GRB2/GSTP1/CCNE1/AKT1/PTEN/ERBB2/BAD/MAP2K2/E2F3/MMP3/HRAS/CREB3	0.223994153711516
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/1085	115/9376	1.05200561009818	MMP15/NACA/MMP14/PDE4D/GNAI1/RHOA/GNAI3/PTH1R/LRP6/GNAS/ADCY3/OXSR1/ADCY5/CREB3	0.202986531837038
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1085	30/9376	1.15219662058372	ABCG2/TYMS/GGH/GART	0.302029802096281
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1085	98/9376	1.05813975359729	CALM1/CALM3/ATP2B4/ATP1B3/HSD3B1/CALM2/CYP11A1/GNAS/PRKD3/ADCY3/ADCY5/CREB3	0.209293668478802
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/1085	158/9376	1.03916467362772	RPS6/GRB2/AKT1/ATP6V1F/PTEN/LAMTOR5/LAMTOR1/SKP2/WNT10B/SLC7A5/RHOA/EIF4EBP1/MAP2K2/LRP6/LAMTOR2/WNT7A/HRAS/ATP6V1B1/CAB39L	0.179598106284994
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/1085	73/9376	1.06538728615618	GRB2/AKT1/ERBB2/BAD/STAT5B/MAP2K2/E2F3/KIF5B/HRAS	0.202880488550359
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/1085	133/9376	1.03957589827102	CALM1/CALM3/GNG5/PPP1CA/PPP2R1A/GNAI1/AKT1/GNB2/CALM2/GNAI3/GNAS/GNG4/KIF5B/ADCY5/PPP2R5A/CREB3	0.166282740964355
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1085	22/9376	1.17838290741517	ALDH2/ALDH7A1/ALDH1B1	0.303014175119409
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/1085	99/9376	1.04745147325792	MMP2/GRB2/AKT1/ERBB2/BAD/MAP2K2/GNAS/SHC1/E2F3/ADCY3/ADCY5/HRAS	0.171696154975866
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/1085	48/9376	1.08018433179724	HSD17B10/ALDH2/ALDH7A1/ACAT2/ALDH1B1/ECHS1	0.201471172607493
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1085	31/9376	1.11502898766166	ALDH2/ALDH7A1/ALDH1B1/ECHS1	0.232057463818461
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1085	31/9376	1.11502898766166	GCSH/MDH2/MDH1/ACAT2	0.232057463818461
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1085	23/9376	1.12714886796233	NUS1/ACAT2/FDPS	0.220850302501735
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1085	23/9376	1.12714886796233	SSBP1/RPA3/POLD2	0.220850302501735
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1085	49/9376	1.05813975359729	GNAI1/GNAI3/GNAS/GRIN2D/ADCY5/CREB3	0.147603714976841
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/1085	136/9376	1.01664407698563	CCNE1/EIF3H/CBLB/AKT1/BAD/STAT5B/CCND3/JAK1/CSNK2B/MX1/IFNAR1/CYCS/IRF7/EIF2S1/MSN/IFNAR2	0.0707278137970225
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1085	32/9376	1.08018433179724	LDHB/LDHA/ECHS1/SUCLG1	0.164359623757592
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1085	41/9376	1.05383837248511	SSBP1/RPA3/POLD2/BRCC3/BRCA1	0.124975171036074
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	25/1085	216/9376	1.00017067759003	CALM1/CALM3/HSP90B1/HSPA5/CYBA/HSPA2/RAC1/CDC42/HSPD1/AKT1/TANK/CALM2/RHOA/BAD/CASP6/PPARG/HSPA4/MMP3/CYCS/IRF7/ROCK2/HRAS/EIF2S1/ATF6/MIB2	0.000918021157532887
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1085	59/9376	1.0252597047567	CGA/GNAI1/AKT1/GNAI3/GNAS/ADCY3/ADCY5	0.0704065846855346
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1085	103/9376	1.00677374614111	RBM8A/PPP1CA/PPP2R1A/SAP18/ALYREF/GSPT1/MAGOH/MAGOHB/SSU72/UPF3B/PPP2R5A/NCBP2	0.0250054370013931
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	20/1085	173/9376	0.999014410910738	ACTB/ACTG1/RAB11A/DNAJC3/VDAC1/SLC25A6/KPNA2/AKT1/MAP2K2/XPO1/CCND3/JAK1/MX1/IFNAR1/CYCS/IRF7/FDPS/EIF2S1/SLC25A4/IFNAR2	-0.00473316099971814
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1085	42/9376	1.02874698266403	ALDH2/ALDH7A1/ACAT2/ALDH1B1/ECHS1	0.0675429560336498
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/1085	226/9376	0.994151951388606	CGA/CALM1/CALM3/PDE4D/RAC1/ATP2B4/PPP1CA/MYL9/ATP1B3/GNAI1/AKT1/RAC3/CALM2/HCAR3/RHOA/GNAI3/BAD/MAP2K2/GNAS/GRIN2D/ROCK1/ADCY3/ROCK2/ADCY5/RRAS/CREB3	-0.0321922770219605
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/1085	60/9376	1.00817204301075	RAC1/CDC42/AKT1/RAC3/BAD/MAP2K2/HRAS	0.0229714589487504
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/1085	122/9376	0.991644632469593	LEP/PFKP/PPP2R1A/SCD/AKT1/EIF4EBP1/RAB10/PPARG/PFKM/RAB2A/GYS1/PPP2R5A/CAB39L/CREB3	-0.0336029786164193
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1085	34/9376	1.01664407698563	NFIL3/RBX1/BHLHE40/CSNK1E	0.0351703178038231
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1085	52/9376	0.997093229351294	CGA/HSD3B1/CYP11A1/GNAS/ADCY3/ADCY5	-0.00760340904909921
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1085	61/9376	0.991644632469593	SLC6A19/ATP2B4/ATP1B3/ATOX1/SLC39A4/SLC8A1/MT1F	-0.0236829662302756
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/1085	168/9376	0.977309633530832	HMGB1/PPIA/PYGL/VDAC1/CHMP2A/SLC25A6/CHMP2B/VDAC2/PARP1/STAT5B/JAK1/CAPN1/IFNAR1/VDAC3/CHMP1B/CHMP4B/CHMP5/SLC25A4/IFNAR2	-0.107352100249979
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/1085	187/9376	0.970432982577195	CYBA/CASP4/YWHAE/VDAC1/TXN2/TXN/TRIP6/TANK/VDAC2/RHOA/JAK1/GBP1/IFNAR1/IRF7/ANTXR2/VDAC3/BRCC3/SUGT1/GSDMD/PRKCD/IFNAR2	-0.14773766967559
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/1085	196/9376	0.969961440797517	HLA-G/HLA-C/CALM1/CALM3/RPS27A/UBA52/GNG5/RAC1/AKT1/GNB2/CALM2/HLA-E/MAP2K2/E2F3/GNG4/JAK1/IFNAR1/CYCS/IRF7/CCR1/HRAS/IFNAR2	-0.153738571969188
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1085	17/9376	1.01664407698563	HSD17B4/SCP2	0.0248465733540301
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/1085	180/9376	0.960163850486431	HLA-G/CALR/HLA-C/PDIA3/B2M/SRSF9/PPP1CA/TAP1/ALYREF/AKT1/ITGA5/EIF4EBP1/HLA-E/BAD/JAK1/IFNAR1/CYCS/IRF7/EIF2S1/IFNAR2	-0.195214096323146
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/1085	91/9376	0.949612599382185	PDE4D/GNG5/GNAI1/GNB2/GNAI3/GNAS/GRK5/GNG4/ADCY3/ADCY5	-0.174722464310257
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/1085	163/9376	0.954273274716576	GRB2/CCNE1/YWHAB/TGFB1/BIRC5/AKT1/YWHAQ/BAD/STAT5B/MAP2K2/E2F3/JAK1/IFNAR1/CYCS/IRF7/VDAC3/HRAS/CREB3	-0.213039638681985
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/1085	83/9376	0.937027372161457	POLR2F/POLR1D/DNASE2/POLR2H/PCBP1/IRF7/POLR2K/POLR2L/GSDMD	-0.208453861231468
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1085	37/9376	0.93421347614896	GPT2/NIT2/ASL/ADSL	-0.14503895532845
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/1085	56/9376	0.92587228439763	BNIP3/HSPD1/EEF1A1/CYCS/VCP/HSF1	-0.20126289886184
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1085	28/9376	0.92587228439763	TCIRG1/ATP6V1F/ATP6V1B1	-0.14210106413342
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1085	102/9376	0.93192373723683	RAB11A/RAC1/ATP2B4/ATP1B3/PLA2G2A/RHOA/PLA2G10/GNAS/ADCY3/ADCY5/BST1	-0.250068676588209
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1085	93/9376	0.929190823051385	CALM1/CALM3/ATP2B4/ATP1B3/CALM2/CST3/GNAS/ADCY3/ADCY5/BST1	-0.2482469350048
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1085	19/9376	0.909628910987145	GCSH/PDHB	-0.142637937751688
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/1085	122/9376	0.920812873007479	GRB2/GNAI1/AKT1/GNAI3/STAT5B/MAP2K2/GNAS/SHC1/ADCY3/ADCY5/HRAS/CRKL/CREB3	-0.318468735856516
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1085	29/9376	0.89394565390116	CALM1/CALM3/CALM2	-0.206913295566977
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/1085	67/9376	0.902840635532017	CALM1/CALM3/PPP1CA/CALM2/MAP2K2/GRIN2D/HRAS	-0.28871383883196
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/1085	49/9376	0.881783127997743	GALNT2/GALNT1/GXYLT1/COLGALT1/C1GALT1C1	-0.300125962028291
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/1085	68/9376	0.889563567362429	GRB2/AKT1/EIF4EBP1/BAD/STAT5B/MAP2K2/HRAS	-0.330624999104351
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1085	20/9376	0.864147465437788	SQLE/LBR	-0.220006081694515
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1085	30/9376	0.864147465437788	PIGS/PIGK/GPAA1	-0.269595434975728
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1085	78/9376	0.886305092756706	PLCD4/TPI1/PTEN/PIK3C2G/SYNJ1/ITPKB/INPP4B/IMPA2	-0.364746045308015
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/1085	69/9376	0.876671341748481	GRB2/RAC1/AKT1/RAC3/MAP2K2/GAB2/HRAS	-0.371946729867113
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1085	69/9376	0.876671341748481	CALM1/CALM3/GNAI1/CALM2/GNAI3/GNAS/ADCY5	-0.371946729867113
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/1085	217/9376	0.915916668436365	HSP90B1/GRB2/MGST3/MGST1/PTGES3/KPNA2/GNAI1/BIRC5/AKT1/EIF4EBP1/GNAI3/KPNB1/BAD/STAT5B/MAP2K2/GSTA4/GNAS/CCND3/ADCY3/GSTO1/ADCY5/HRAS/CREB3	-0.453328265037821
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/1085	60/9376	0.864147465437788	PPP2R1A/GNAI1/GNAI3/MAP2K2/GNAS/HRAS	-0.381878915305919
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/1085	98/9376	0.881783127997743	CALM1/CALM3/PLCD4/PTEN/CALM2/PIK3C2G/SYNJ1/ITPKB/INPP4B/IMPA2	-0.425561535551366
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1085	31/9376	0.836271740746246	ALDH2/ALDH7A1/ALDH1B1	-0.330302520870578
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1085	21/9376	0.822997586131227	ALDH2/ALDH1B1	-0.293740608538234
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1085	71/9376	0.851976374375284	CGA/GRB2/AKT1/STAT5B/MAP2K2/SHC1/HRAS	-0.452896612951288
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/1085	71/9376	0.851976374375284	JAM3/RAC1/CDC42/TCIRG1/ATP6V1F/F11R/ATP6V1B1	-0.452896612951288
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1085	91/9376	0.854651339443966	GRB2/RAC1/AKT1/RAC3/IFITM1/MAP2K2/CD81/HRAS/BCL10	-0.504008459360101
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/1085	110/9376	0.864147465437788	LRRC32/ID3/TGFB1/PPP2R1A/RBX1/ID1/RHOA/ROCK1/DCN/HDAC2/TFDP1	-0.518459682670348
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1085	110/9376	0.864147465437788	CCNB1/ANAPC11/GNAI1/AKT1/CCNB2/GNAI3/MAD2L1/ADCY3/CDK1/AURKA/ADCY5	-0.518459682670348
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1085	43/9376	0.803858107383989	AGPAT2/PLA2G2A/PLA2G10/ACAT2	-0.466327477456609
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1085	63/9376	0.822997586131227	PTGDS/PTGES3/GPX4/PLA2G2A/PLA2G10/CBR1	-0.509919607755363
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1085	33/9376	0.785588604943444	GPT2/IDH1/PDHB	-0.446332701786026
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/1085	33/9376	0.785588604943444	YKT6/VTI1B/STX6	-0.446332701786026
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/1085	149/9376	0.869947112856834	GRB2/RALB/AGPAT2/AKT1/RHOA/MAP2K2/GNAS/RALA/SHC1/ADCY3/GAB2/AGPAT5/ADCY5/HRAS/RRAS	-0.578868505426101
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/1085	73/9376	0.828634555899249	CDH1/AKT1/PTEN/BAD/MAP2K2/E2F3/HRAS	-0.531704358195409
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/1085	83/9376	0.832913219699073	ACSL4/PRDX5/NOS2/HSD17B4/IDH1/ECH1/SCP2/NUDT12	-0.553095618047946
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/1085	112/9376	0.848716260697828	LAMA4/TGFB1/ITGB1/GNAI1/AKT1/NOS2/GNAI3/LAMB1/BAD/JAK1/CYCS	-0.582638311500654
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1085	23/9376	0.751432578641555	LNPEP/ATP6AP2	-0.431747376747009
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1085	23/9376	0.751432578641555	ATP1B3/MDH1	-0.431747376747009
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/1085	150/9376	0.864147465437788	GRB2/CDH1/CCNE1/TGFB1/AKT1/ERBB2/WNT10B/MAP2K2/LRP6/AXIN1/SHC1/E2F3/CTNNA1/WNT7A/HRAS	-0.606741497971445
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1085	44/9376	0.785588604943444	HLA-G/HLA-C/HSPD1/HLA-E	-0.515684271415146
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/1085	169/9376	0.869260764049846	HMGB1/RPS27A/CTSL/UBA52/BNIP3/AKT1/PTEN/TANK/NRBF2/BAD/MAP2K2/YKT6/HRAS/IGBP1/EIF2S1/PRKCD/RRAS	-0.620422119509792
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/1085	103/9376	0.83897812178426	SLC6A19/COL1A1/COL3A1/ATP1B3/COL9A3/COL1A2/COL6A3/SLC8A1/COL18A1/COL6A2	-0.594415903355445
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/1085	65/9376	0.797674583481035	ALDH2/ALDH7A1/AGPAT2/AKR1B1/ALDH1B1/AGPAT5	-0.592114924575913
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1085	65/9376	0.797674583481035	HSD3B1/CYP11A1/GNAS/ADCY3/ADCY5/CREB3	-0.592114924575913
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/1085	133/9376	0.844655417345206	GRB2/CCNB1/BNIP3/TGFB1/AKT1/PTEN/SKP2/CCNB2/CSNK1E/MAP2K2/PRMT1/CCNG2/HRAS	-0.652698337278574
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/1085	105/9376	0.822997586131227	CALM1/CALM3/CBLB/AKT1/CALM2/RHOA/HRAS/PRKCD/RRAS/BCL10	-0.659792839220741
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/1085	76/9376	0.795925297113752	PLTP/ACSL4/SCD/SLC27A6/PPARG/DBI/SCP2	-0.646177072560139
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/1085	144/9376	0.840143369175627	LIFR/GRB2/FGFR3/ID3/DLX5/AKT1/ID1/WNT10B/MAP2K2/AXIN1/JAK1/WNT7A/HRAS/REST	-0.699296014868141
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1085	36/9376	0.720122887864823	UGP2/AKR1B1/DCXR	-0.608614431356158
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1085	47/9376	0.735444651436415	PKM/HK2/HK1/PRKCD	-0.657725952138615
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1085	37/9376	0.70066010711172	ADH5/MIF/GSTZ1	-0.659951959932596
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1085	37/9376	0.70066010711172	HBA2/HBA1/LAMA4	-0.659951959932596
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1085	26/9376	0.664728819567529	PLA2G2A/PLA2G10	-0.619261587538129
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1085	48/9376	0.720122887864823	ATP1B3/AKT1/HK2/HK1	-0.703219303622323
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1085	79/9376	0.765700285830952	GSTP1/MGST3/MGST1/ADH5/GSTA4/GSTO1/CBR1	-0.756503494813302
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/1085	99/9376	0.785588604943444	CALM1/CALM3/PPP1CA/CALM2/GNAS/ADCY3/ADCY5/IL1R1/PRKCD	-0.775815998675528
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/1085	109/9376	0.792795839851182	SLC2A1/PYGL/PPP1CA/PPP1R3B/AKT1/PTEN/SLC27A6/GYS1/PRKCD/CREB3	-0.787116810780622
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/1085	148/9376	0.81743679163034	GRB2/FLT4/AKT1/PTEN/ERBB2/WNT10B/MAP2K2/LRP6/AXIN1/SHC1/E2F3/WNT7A/HRAS/BRCA1	-0.809817903478883
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1085	38/9376	0.682221683240359	NNMT/BST1/NUDT12	-0.710045490435802
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1085	38/9376	0.682221683240359	ADA/TAP1/RFXANK	-0.710045490435802
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1085	70/9376	0.740697827518104	GSTP1/MGST3/MGST1/GSTA4/GSTO1/CBR1	-0.787717875658165
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1085	27/9376	0.640109233657621	ACAT2/ECHS1	-0.677434103343131
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1085	15/9376	0.576098310291859	ST3GAL1	-0.594356072646756
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1085	39/9376	0.664728819567529	HLA-G/HLA-C/HLA-E	-0.758965259820978
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/1085	122/9376	0.779149354083251	GRB2/CDC42/CBLB/PPP2R1A/AKT1/RHOA/MAP2K2/PAK4/HRAS/PPP2R5A/BCL10	-0.888200250336709
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/1085	181/9376	0.811630216157038	CALM1/CALM3/HSPD1/TGFB1/TCIRG1/AKT1/CALM2/NOS2/RHOA/NFYB/BAD/EEA1/JAK1/HSPA9/CYCS/BCL10/RFXANK	-0.925703082280099
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/1085	62/9376	0.696893117288539	AKT1/ADCY3/HDAC2/ADCY5/HRAS	-0.866204779575135
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1085	16/9376	0.540092165898618	MIF	-0.666024068976447
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1085	16/9376	0.540092165898618	ST3GAL1	-0.666024068976447
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1085	73/9376	0.710258190770785	GSTP1/MGST3/MGST1/ADH5/GSTA4/GSTO1	-0.898996781568293
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1085	29/9376	0.59596376926744	CSNK1E/RASSF6	-0.788279510501341
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/1085	115/9376	0.751432578641555	GNG5/GNAI1/AKT1/GNB2/GNAI3/GNG4/ADCY3/ADCY5/HRAS/CREB3	-0.970199920623474
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/1085	155/9376	0.780520291363163	CCNE1/GNAI1/HSD3B1/WNT10B/GNAI3/CYP11A1/MAP2K2/AXIN1/GNAS/E2F3/ADCY3/WNT7A/ADCY5/CREB3	-0.996708731368687
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1085	30/9376	0.576098310291859	PLA2G2A/PLA2G10	-0.841220672047736
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/1085	65/9376	0.664728819567529	CGA/AKT1/MAP2K2/KISS1R/HRAS	-0.981187006209086
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1085	54/9376	0.640109233657621	HLA-G/CGA/HLA-C/HLA-E	-0.959422909475761
NA	NA	hsa04981	Folate transport and metabolism	2/1085	31/9376	0.557514493830831	ABCG2/TYMS	-0.892662505559616
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/1085	178/9376	0.776761766685652	RAC1/LGR4/RBX1/RAC3/RUVBL1/WNT10B/RHOA/CSNK1E/CACYBP/LRP6/AXIN1/CCND3/CSNK2B/WNT7A/DKK1/ROCK2	-1.08774958218733
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1085	18/9376	0.480081925243216	ACSL4	-0.798687150840504
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1085	18/9376	0.480081925243216	FUCA2	-0.798687150840504
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1085	18/9376	0.480081925243216	MMADHC	-0.798687150840504
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/1085	160/9376	0.756129032258064	HLA-G/HLA-C/CDH1/JAM3/CD276/CLDN6/ITGB1/CLDN7/ITGAV/CLDN10/HLA-E/F11R/SDC1/NLGN2	-1.12550106341702
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/1085	32/9376	0.540092165898618	BIRC5/CYCS	-0.942706347759061
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/1085	99/9376	0.69830098217195	GRB2/RAC1/AKT1/RAC3/EIF4EBP1/MAP2K2/SLC44A2/HRAS	-1.09165338322599
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/1085	78/9376	0.664728819567529	CYBA/TGFB1/ITGB1/EEF1A1/NOS2/JAK1	-1.07558764181767
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/1085	89/9376	0.679666545849946	GNG5/GNAI1/GNB2/GNAI3/GNG4/ADCY3/ADCY5	-1.09839014336979
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1085	191/9376	0.769136487562429	CALM1/CALM3/GRB2/GNG5/PPP1CA/GNAI1/GNB2/CALM2/GNAI3/GNAS/GRIN2D/SHC1/GNG4/HDAC2/ADCY5/HRAS/CREB3	-1.16608296768335
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1085	45/9376	0.576098310291859	ABCG2/ABCA7/TAP1	-1.03110848242462
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1085	45/9376	0.576098310291859	HLA-G/HLA-C/HLA-E	-1.03110848242462
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/1085	79/9376	0.656314530712244	TCIRG1/ATP6V1F/CLTA/AP2M1/ATP6V1B1/UNC13B	-1.10968662319898
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/1085	90/9376	0.672114695340502	AKT1/EIF4EBP1/PPARG/ADCY3/ADCY5/HRAS/CREB3	-1.13064409120465
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	16/1085	183/9376	0.75553876759588	RAN/FBL/NHP2/NOP58/NOP56/NOP10/XPO1/CSNK2B/POP7/RBM28/MPHOSPH10/GAR1/IMP4/XRN2/BMS1/POP5	-1.20810299606828
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/1085	133/9376	0.714708430061328	HLA-G/HLA-C/GRB2/RAC1/RAC3/HLA-E/MAP2K2/SHC1/IFNAR1/HRAS/IFNAR2	-1.19868572277386
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/1085	103/9376	0.671182497427408	CALR/TGFB1/PPP2R1A/GNAI1/AKT1/NOS2/GNAI3/GNAS	-1.21383724371228
NA	NA	hsa04382	Cornified envelope formation	19/1085	217/9376	0.756626813056128	S100A11/PADI1/DSP/DSG2/S100A6/TCHH/FURIN/CLDN6/PPP2R1A/CLDN7/CLDN10/KRT10/PRSS8/CAPN1/BLMH/PPP2R5A/SPTLC1/ELOVL1/PKP3	-1.31212622695015
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/1085	115/9376	0.676289320777399	APP/GNG5/GNAI1/GNB2/GNAI3/GNAS/GNG4/ADCY5/HRAS	-1.2634965337386
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1085	72/9376	0.600102406554019	ISG15/TANK/DHX58/IRF7/PIN1	-1.23218874528684
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/1085	116/9376	0.67045924042587	GNG5/GNAI1/GNB2/GNAI3/GNAS/GRIN2D/GNG4/ADCY3/ADCY5	-1.29190235344949
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1085	86/9376	0.602893580537992	SLC2A1/ATP1B3/GNAS/ADCY3/ADCY5/CREB3	-1.33827487985358
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1085	51/9376	0.508322038492816	PLA2G2A/PLA2G10/PAFAH1B3	-1.27361586375912
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/1085	142/9376	0.669410008437723	GRB2/CYBA/RAC1/TGFB1/AKT1/PPARG/JAK1/IFNAR1/GAB2/IL1R1/IFNAR2	-1.43593899050946
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1085	66/9376	0.523725736628962	HSD3B1/SRD5A3/HSD17B12/CYP11A1	-1.40459555916077
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1085	90/9376	0.576098310291859	SLC2A1/ABCG2/ATP1B3/GNAS/ADCY3/ADCY5	-1.46173657040806
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/1085	90/9376	0.576098310291859	AKT1/PTEN/MAP2K2/JAK1/CSNK2B/HRAS	-1.46173657040806
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/1085	54/9376	0.480081925243216	RPA3/UBE2T/BRCA1	-1.3860353157759
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1085	26/9376	0.332364409783765	AMN	-1.23315423342072
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/1085	254/9376	0.714452628905258	CALM1/CALM3/FLT4/PLCD4/VDAC1/ATP2B4/FGFR3/SLC25A6/ERBB2/CALM2/NOS2/VDAC2/TACR3/ITPKB/GNAS/GRIN2D/ADCY3/VDAC3/SLC8A1/MST1/SLC25A4	-1.6689642740462
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/1085	70/9376	0.493798551678736	LEP/SLC2A1/ACSL4/AKT1	-1.53775776620056
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/1085	95/9376	0.545777346592287	CTSL/TGFB1/TCIRG1/ATP6V1F/MMP3/ATP6V1B1	-1.60964556001163
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/1085	195/9376	0.664728819567529	ACTB/HMGB1/CYBA/ACTG1/CASP4/RAC1/VDAC1/SLC25A6/AKT1/VDAC2/MAP2K2/VDAC3/HDAC2/GSDMD/SLC25A4	-1.71145539680006
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/1085	109/9376	0.554957087895827	RAC1/AKT1/MAP2K2/JAK1/IFNAR1/IRF7/IFNAR2	-1.69060677828266
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/1085	62/9376	0.418135870373123	MAML3/PSENEN/HDAC2	-1.66282430025159
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1085	88/9376	0.490992878089652	TFPI/PROCR/CD55/C1R/THBD	-1.7354061866379
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/1085	32/9376	0.270046082949309	IGBP1	-1.49623933351739
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/1085	63/9376	0.411498793065613	WNT10B/AXIN1/WNT7A	-1.69539102910778
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/1085	300/9376	0.69131797235023	GRB2/PGF/FLT4/RAC1/CDC42/EFNA1/FGFR3/STMN1/FLNA/ANGPT4/TGFB1/MAP4K4/AKT1/RAC3/ERBB2/EFNA4/EPHA2/MAP2K2/TAOK3/HRAS/EFNA3/IL1R1/RRAS/CRKL	-1.96572054974508
NA	NA	hsa04081	Hormone signaling	16/1085	219/9376	0.631340614018475	CGA/LEP/GNG5/GNAI1/ITGAV/GNB2/RHOA/GNAI3/STAT5B/PTH1R/GNAS/GNG4/ADCY3/SLC16A2/ADCY5/NPPC	-1.99695277912153
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/1085	83/9376	0.416456609849536	CSNK2B/YY1/HDAC2/TFDP1	-1.93166264531386
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/1085	38/9376	0.227407227746786	ATP1B3	-1.72628522762495
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/1085	100/9376	0.432073732718894	GYPA/CD55/CD7/ITGA5/IL1R1	-2.06542122434049
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1085	41/9376	0.210767674497021	GRIN2D	-1.83204729849918
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/1085	168/9376	0.514373491332017	LEP/LIFR/GRB2/AKT1/STAT5B/CCND3/JAK1/IFNAR1/HRAS/IFNAR2	-2.29758411850294
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/1085	94/9376	0.367722325718208	HSP90B1/MMP3/IL17RA/TRAF4	-2.22868167226114
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/1085	323/9376	0.615337204491304	GRB2/CCNE1/EFNA1/FGFR3/STMN1/IGF2BP1/PTEN/TRIM71/ERBB2/ITGA5/HNRNPK/RHOA/EFNA4/MAP2K2/ROCK1/SHC1/E2F3/PAK4/HDAC2/HRAS/EFNA3/BRCA1/CRKL	-2.54496746217394
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1085	50/9376	0.172829493087558	TGFB1	-2.12143332810537
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1085	143/9376	0.4230092488157	ACTN1/SNRPD1/SSB/SNRPB/ACTN4/SNRPD3/C1R	-2.51514195889214
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/1085	144/9376	0.420071684587814	ADH5/ALDH2/SCD/ALDH7A1/AKT1/ALDH1B1/IL17RA	-2.53690796425258
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/1085	104/9376	0.332364409783765	AGPAT2/PLA2G2A/PLA2G10/AGPAT5	-2.47666055778214
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/1085	105/9376	0.329199034452491	PARP1/CSNK2B/IL1R1/BCL10	-2.50047252993247
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/1085	56/9376	0.154312047399605	CSNK1E	-2.29611296516803
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/1085	93/9376	0.278757246915415	STAT5B/MAML3/JAK1	-2.52857483398801
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/1085	109/9376	0.317118335940473	TGFB1/STAT5B/JAK1/IL1R1	-2.59409674578469
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1085	100/9376	0.259244239631336	CXCL14/CCR1/CCR7	-2.69396356122515
NA	NA	hsa04082	Neuroactive ligand signaling	10/1085	199/9376	0.434244957506426	GNG5/GNAI1/GNB2/GNAI3/TACR3/GNAS/GRIN2D/GNG4/ADCY3/ADCY5	-2.91810997749031
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/1085	119/9376	0.290469736281609	MMP14/AKT1/MMP3/CREB3	-2.81777507226241
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1085	66/9376	0.130931434157241	TGFB1	-2.56299771385713
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1085	68/9376	0.127080509623204	ADH5	-2.61334958791318
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/1085	99/9376	0.174575245542987	KRT10/C1R	-2.98667769052878
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/1085	201/9376	0.300946878510672	MYCN/PPARG/MMP3/ETV4/HDAC2/TLX3/BMP2K	-3.62411709517334
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/1085	298/9376	0.318980608047506	LEP/LIFR/TGFB1/CXCL14/ACVRL1/IFNAR1/IL17RA/CCR1/IL1R1/CCR7/IFNAR2	-4.32184882112147
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/1085	370/9376	0.256908705940964	CGA/LEP/TMEM97/GAL/TSPO/PTH1R/TACR3/GRIN2D/KISS1R/NMB/PGRMC2	-5.27562738135375
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1085	449/9376	0.096230230004208	CALM1/CALM3/CALM2/ADCY3/SLC8A1	-7.09945913087492