category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	99/904	222/9376	4.62520928007654	RPL36/RPL29/RPLP0/RPL39/RPL7A/RPL37/RPS4X/RPL18/RPS2/RPS3A/RPL13/RPS18/RPS6/RPL28/RPL18A/RPL6/RPS19/RPL8/RPL11/RPS5/RPS23/RPL5/RPS3/RPS15/RPS7/RPS14/RPSA/RPL37A/RPL32/RPL14/RPS24/RPL24/RPL19/RPL23A/RPL10/RPL35A/RPS8/RPLP1/RPS27A/RPL26/RPS9/RPS27/RPS16/RPLP2/RPL15/RPL34/RPL3/RPL10A/RPL7/RPL35/RPS28/RPS13/RPS11/RPL22/RPL12/RPS29/RPL23/RPL27A/RPL30/RPL9/RPS25/RPS12/RPL13A/RPL4/RPL38/RPS15A/RPL21/RPL27/RPS21/UBA52/RPL41/RPL31/RPS20/RPS26/RPS10/RPL22L1/FAU/RPL36A/RPL17/MRPL51/MRPS15/MRPL11/MRPL23/MRPL14/MRPL52/MRPS6/MRPS21/MRPS33/MRPL12/MRPL16/MRPS12/MRPS31/DAP3/MRPS27/MRPL41/MRPS9/MRPL21/MRPL39/MRPL50	17.8558692084986
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	84/904	238/9376	3.66059344091619	RPL36/RPL29/RPLP0/RPL39/RPL7A/RPL37/RPS4X/RPL18/RPS2/RPS3A/RPL13/RPS18/RPS6/RPL28/RPL18A/RPL6/RPS19/RPL8/RPL11/RPS5/RPS23/RPL5/RPS3/RPS15/RPS7/RPS14/RPSA/RPL37A/RPL32/RPL14/RPS24/RPL24/RPL19/RPL23A/RPL10/RPL35A/RPS8/RPLP1/RPS27A/RPL26/RPS9/RPS27/RPS16/RPLP2/RPL15/RPL34/RPL3/RPL10A/RPL7/RPL35/RPS28/RPS13/RPS11/RPL22/RPL12/RPS29/RPL23/RPL27A/RPL30/RPL9/RPS25/RPS12/RPL13A/RPL4/RPL38/RPS15A/RPL21/RPL27/RPS21/UBA52/RPL41/RPL31/RPS20/C1R/RPS26/CFD/RPS10/RPL22L1/FAU/RPL36A/RPL17/C1S/IFNAR2/MMP3	13.5805793571315
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	54/904	158/9376	3.54475187633023	CCNE1/CCNB1/CDKN1C/PTTG1/SKP2/CDC20/MAD2L1/CDK1/CCNB2/AURKB/YWHAQ/CDC6/CDT1/CCNA2/WEE1/CDK7/ORC6/MCM7/TTK/CHEK1/PKMYT1/YWHAB/CDK2/MCM6/CDC45/CDCA5/YWHAE/MCM5/ORC1/BUB1/MAD1L1/NDC80/PLK1/MYC/MCM3/TFDP1/ANAPC11/E2F5/TRIP13/CCND2/CHEK2/ESCO2/E2F1/PRKDC/TICRR/FBXO5/DBF4/BUB1B/CDC25C/CDC25A/DDX11/MCM2/SFN/GADD45A	10.5373769143301
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	16/904	36/9376	4.60963618485742	RNASEH2A/MCM7/RPA3/SSBP1/FEN1/POLD2/MCM6/MCM5/MCM3/LIG1/POLE2/RFC5/RFC3/RFC4/MCM2/PRIM2	7.08790884704112
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	31/904	116/9376	2.77174244736039	GAPDH/ENO1/PKM/TPI1/IDH2/ACAT2/GCSH/ADH5/ALDOA/PGK1/GPT2/PFKP/RPIA/HK1/MDH2/PGAM1/GLDC/IDH1/PCCA/SDHA/ECHS1/TALDO1/TKT/PRPS2/PGP/PHGDH/GPI/AGXT/SHMT1/ALDOC/SDHC	6.27192665908216
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	49/904	233/9376	2.18116905313533	COL1A1/TPM1/ACTB/ACTG1/ENO1/COL3A1/COL6A2/TPM2/COL1A2/COL4A1/DCN/COL4A2/TPM4/COL6A3/VCAN/TNNI2/MYL4/DSC2/DSP/COL6A1/COL27A1/LMNB1/MYL9/DIAPH3/COL5A2/ITGB1/NID1/COL5A1/FHL2/MYH10/LMNB2/ITGA1/SPTBN1/COL9A3/SDC4/CSRP2/MYH9/VCL/PDLIM1/HSPG2/THBS1/SSPN/LMOD1/MYL3/FBLN2/SGCB/FLNC/NID2/LBR	5.96379271765166
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	52/904	268/9376	2.01241579712059	RPS27A/TUBA1B/TUBB/GNAS/HSPA5/TUBA1C/UBA52/UQCRH/TUBB6/CALM3/PSMA7/SLC25A6/TUBB4B/NDUFA4/TXN2/NDUFB11/COX7C/GNAI1/PSMD14/COX5A/PSMA4/VDAC1/COX6C/COX8C/COX5B/PSMD11/VDAC2/SLC39A4/SLC25A5/PSMB2/SLC39A10/ADCY5/PSMA1/PSMB5/SDHA/NDUFA4L2/COX7A1/PSMB3/PSMC4/GNAI3/TH/UQCRFS1/NDUFA3/PSMB6/PSMC1/UBE2L3/PSMD4/PSMD13/NDUFS4/PSMC3/PSMD3/SDHC	5.49277334965656
NA	NA	hsa04518	Integrin signaling	35/904	154/9376	2.35720032180209	COL1A1/ACTB/ACTG1/COL6A2/COL1A2/COL4A1/COL4A2/LAMA4/ACTN1/COL6A3/COL6A1/FLNB/RAC3/CTNNB1/PGF/ITGB1/LAMB1/RAC1/ITGA1/CDC42/CDH1/PARVA/ACTN4/PXN/COL9A3/IGF1/AKT1/FLT4/PDGFRB/VCL/CCND2/PDGFRA/THBS1/FERMT2/FERMT1	5.54713372181185
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	22/904	75/9376	3.0423598820059	GAPDH/ENO1/PKM/TPI1/ARG2/IDH2/CBS/ALDOA/PGK1/GPT2/PFKP/RPIA/PGAM1/IDH1/CTH/TALDO1/TKT/PRPS2/PHGDH/SHMT1/ALDOC/ASL	5.80062727635086
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/904	203/9376	2.14586512053708	COL1A1/ACTB/ACTG1/CAV1/COL6A2/COL1A2/COL4A1/COL4A2/LAMA4/ACTN1/COL6A3/COL6A1/MYL9/FLNB/RAC3/CTNNB1/PGF/ITGB1/LAMB1/BRAF/PPP1CA/CAV2/GRB2/RAC1/FYN/ITGA1/CDC42/PARVA/ACTN4/PXN/VASP/COL9A3/IGF1/AKT1/FLT4/PDGFRB/PPP1CB/VCL/CCND2/PDGFRA/THBS1/PAK3	5.39141424833675
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/904	46/9376	3.60754136206233	PSMA7/POMP/PSMD14/PSMA4/PSMD11/PSMB2/PSMA1/PSMB5/PSMB3/PSMC4/PSMB6/PSMC1/PSMD4/PSMD13/PSMC3/PSMD3	5.79090152806494
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	35/904	174/9376	2.08625775607771	CALR/PDIA6/SSR2/HSPA5/PDIA3/OSTC/P4HB/SSR3/PDIA4/LMAN1/HSP90B1/HSP90AB1/HERPUD1/DAD1/MAN1A2/DDOST/SAR1A/VCP/SEC61G/SEC61B/DNAJB11/TMEM258/STT3B/ERLEC1/ERP29/LMAN2/DNAJC3/CKAP4/STT3A/DNAJC10/EDEM2/RPN2/TUSC3/SEC61A1/SEC13	4.72436322198079
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	60/904	368/9376	1.69103501346672	GPX3/ACTB/ACTG1/TUBA1B/TUBB/HNRNPA1/HSPA5/TUBA1C/UQCRH/TUBB6/PFN1/HNRNPA3/PSMA7/HNRNPA2B1/TUBB4B/NDUFA4/SLC1A2/GPX8/NDUFB11/ALYREF/COX7C/PSMD14/COX5A/VCP/PSMA4/VDAC1/RAC1/COX6C/COX8C/COX5B/SRSF3/PSMD11/PSMB2/MAP1LC3A/PSMA1/SRSF7/PSMB5/TOMM40/SDHA/NDUFA4L2/NUP37/COX7A1/PPP3CA/PSMB3/TNFRSF1B/PSMC4/UQCRFS1/NDUFA3/PSMB6/PSMC1/PSMD4/PSMD13/NRBF2/HAP1/SEC13/NDUFS4/PSMC3/PSMD3/SDHC/HNRNPA1L2	4.41760268544397
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	47/904	275/9376	1.77261464199517	TUBA1B/CAV1/TUBB/HSPA5/TUBA1C/UQCRH/TUBB6/PSMA7/SLC25A6/TUBB4B/NDUFA4/NDUFB11/COX7C/PSMD14/COX5A/CAV2/PSMA4/VDAC1/EGR1/RAC1/COX6C/FYN/COX8C/COX5B/PSMD11/VDAC2/SLC25A5/PSMB2/PSMA1/PSMB5/SDHA/NDUFA4L2/COX7A1/PPP3CA/PSMB3/PSMC4/UQCRFS1/NDUFA3/PSMB6/PSMC1/STIP1/PSMD4/PSMD13/NDUFS4/PSMC3/PSMD3/SDHC	4.24777597163801
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	51/904	308/9376	1.71738880588438	GPX3/TUBA1B/TUBB/TUBA1C/UQCRH/TUBB6/PPARG/PSMA7/SLC25A6/TUBB4B/NDUFA4/SLC1A2/GPX8/POLR2L/NDUFB11/COX7C/PSMD14/COX5A/PSMA4/VDAC1/COX6C/COX8C/COX5B/PSMD11/VDAC2/SLC25A5/PSMB2/PSMA1/PSMB5/SDHA/NDUFA4L2/COX7A1/PSMB3/PSMC4/POLR2H/TBPL1/TFAM/UQCRFS1/NDUFA3/PSMB6/PSMC1/PSMD4/PSMD13/POLR2I/NRBF2/HAP1/NDUFS4/PSMC3/PSMD3/SDHC/POLR2E	4.18168271912172
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/904	23/9376	4.05848403232012	RPA3/SSBP1/POLD2/EXO1/LIG1/MSH2/RFC5/RFC3/RFC4	4.79702021044526
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/904	44/9376	3.06436041834272	HMGB1/PARP1/FEN1/POLD2/APEX1/UNG/LIG1/POLE2/RFC5/NEIL3/RFC3/RFC4/NTHL1	4.48333691394165
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	12/904	39/9376	3.19128658951668	TYMS/CBS/GCSH/ALDH7A1/MTHFD1L/DHFR/GLDC/CTH/MTHFD2/MTHFD1/SHMT1/ATIC	4.47924363151749
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/904	75/9376	2.48920353982301	CCNE1/CCNB1/RRM2/CDK1/CCNB2/IGFBP3/CHEK1/GTSE1/CDK2/PERP/IGF1/SIVA1/EI24/CCND2/CHEK2/THBS1/SFN/GADD45A	4.2295751837093
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/904	20/9376	4.14867256637168	SQLE/MSMO1/EBP/DHCR24/DHCR7/FDFT1/HSD17B7/LBR	4.60441299989878
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	12/904	41/9376	3.03561407295489	CBS/GCSH/ALDH7A1/ALAS2/PGAM1/GLDC/GAMT/CTH/GCAT/PHGDH/AGXT/SHMT1	4.26684721111061
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/904	78/9376	2.39346494213751	ACTB/ACTG1/CAV1/CTNNB1/ITGB1/CAV2/RAC1/CDC42/CDH1/PXN/ACTR3/ARPC2/ARPC3/VCL/ARHGAP10/CTTN/ARPC4/ARPC1A	4.03669054275202
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	29/904	157/9376	1.91578828701877	HLA-G/CCNE1/CCNB1/CDK1/CCNB2/CALM3/SLC25A6/IGFBP3/CCNA2/PPP1CA/CHEK1/VDAC1/EIF4EBP1/MYBL2/CDK2/VDAC2/SLC25A5/AKT1/MYC/E2F5/PPP3CA/PPP1CB/FOXM1/CCND2/CHEK2/E2F1/CDC25A/MAP2K2/GADD45A	3.77989628157673
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/904	31/9376	3.34570368255781	HSPA5/SEC11A/SPCS3/SEC61G/SEC61B/SRPRB/SEC11C/SRP72/SRP19/SEC61A1	4.27308196694347
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/904	93/9376	2.23046912170521	ACTB/ACTG1/ACTN1/TCF7L2/MYL9/RAC3/CTNNB1/RAC1/FYN/CDC42/CDH1/ACTN4/CDH5/ACP1/VCL/FGFR1/HEG1/SNAI2/IQGAP1/PARD3	3.89533576720674
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/904	67/9376	2.47681944260996	GAPDH/LDHA/ENO1/LDHB/PKM/TPI1/ALDH7A1/ADH5/ALDOA/PGK1/PFKP/HK1/PGAM1/ALDH1B1/GPI/ALDOC	3.96269062442252
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	36/904	212/9376	1.76122891968609	ACTB/ACTG1/GNAS/PFN1/CALM3/EFNA1/RAC3/CTNNB1/PGF/ITGB1/ID1/GNAI1/BRAF/ENAH/RAC1/CDC42/CDH1/VASP/IGF1/ADCY5/AKT1/FLT4/ANGPT4/PDGFRB/RASGRP2/GNAI3/FGFR1/FGFR3/PDGFRA/THBS1/EFNA3/MAP2K2/PARD3/FGF7/LPAR3/FGF2	3.66199333231244
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/904	116/9376	2.05645407384803	MMP2/ACTB/ACTG1/ACTN1/JAM3/MYL9/CLDN10/THY1/CTNNB1/ITGB1/CLDN6/GNAI1/RAC1/CDC42/ACTN4/CLDN19/PXN/VASP/CDH5/CXCL12/CLDN3/VCL/GNAI3	3.73982261345891
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/904	138/9376	1.95408490445043	CCNE1/CCNB1/PTTG1/CDC20/MAD2L1/CDK1/CCNB2/CALM3/AURKA/YWHAQ/PPP1CA/PKMYT1/YWHAB/CDK2/YWHAE/BUB1/MAD1L1/IGF1/ADCY5/PLK1/ANAPC11/PPP3CA/PPP1CB/PGR/FBXO5/CDC25C	3.68820004345053
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/904	44/9376	2.82864038616251	OSTC/DAD1/MAN1A2/DDOST/B4GALT1/TMEM258/STT3B/ALG9/STT3A/MAN2A1/RPN2/TUSC3	3.9714048345243
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	22/904	110/9376	2.07433628318584	CCNB1/MAD2L1/CDK1/CCNB2/HSP90AB1/AURKA/CCNA2/GNAI1/BRAF/PKMYT1/CDK2/BUB1/MAD1L1/IGF1/ADCY5/AKT1/PLK1/ANAPC11/GNAI3/PGR/CDC25C/CDC25A	3.7022634349723
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	38/904	232/9376	1.69880988709185	ACTB/ACTG1/PFN1/ACTN1/MYL9/DIAPH3/CFL1/RAC3/ITGB1/BRAF/PPP1CA/ENAH/MYH10/RAC1/ITGA1/CDC42/ACTN4/PXN/CXCL12/AKT1/ACTR3/ARPC2/ARPC3/MYH9/PDGFRB/PPP1CB/VCL/FGFR1/FGFR3/PDGFRA/PAK3/IQGAP1/CYFIP2/ARPC4/ARPC1A/MAP2K2/FGF7/FGF2	3.52056044026223
Cellular Processes	Cell motility	hsa04814	Motor proteins	33/904	194/9376	1.76425508621476	TPM1/ACTB/ACTG1/TUBA1B/TUBB/TUBA1C/TPM2/MYO10/TUBB6/MYL6/TPM4/TNNI2/MYL4/TUBB4B/MYL9/ACTA2/CENPE/MYO1B/MYH10/KIF2C/KIFC1/KIF23/KIF11/DYNLL1/KIF4A/KIF20A/KIF20B/MYH9/MYL6B/KIF14/MYL3/KIF15/KIF18A	3.51356051841484
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/904	71/9376	2.33728031908264	LDHA/LDHB/PKM/IDH2/SLC16A3/PFKP/HK1/PGAM1/IDH1/AKT1/MYC/PDGFRB/FGFR1/FGFR3/PDGFRA/MAP2K2	3.69462460869658
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/904	85/9376	2.19635606454971	RRM2/TK1/TYMS/IMPDH2/NME1/ADA/AK5/APRT/NME2/DUT/AK4/DTYMK/PNP/NME1-NME2/ENPP1/GMPS/HDDC2/AK2	3.61922487489988
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	56/904	388/9376	1.49694370951556	GAPDH/TUBA1B/TUBB/TUBA1C/UQCRH/TUBB6/CALM3/PSMA7/SLC25A6/DKK1/TUBB4B/NDUFA4/HSD17B10/CTNNB1/NDUFB11/COX7C/PSMD14/COX5A/BRAF/APP/PSMA4/VDAC1/COX6C/COX8C/COX5B/PSMD11/VDAC2/SLC39A4/SLC25A5/PSMB2/SLC39A10/AKT1/PSMA1/PSMB5/SDHA/NDUFA4L2/COX7A1/PPP3CA/PSMB3/CSNK1E/PSMC4/AXIN2/UQCRFS1/NDUFA3/AXIN1/PSMB6/PSMC1/PSMD4/PSMD13/NRBF2/MAP2K2/NDUFS4/PSMC3/PSMD3/LRP6/SDHC	3.26564076221916
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/904	204/9376	1.67777199375325	RPS6/COL1A1/MMP2/ACTB/ACTG1/CAV1/COL1A2/LUM/DCN/CTNNB1/ITGB1/BRAF/PPP1CA/CAV2/GRB2/GPC1/RAC1/EIF4B/CDC42/PXN/IGF1/AKT1/MYC/SDC4/PPP1CB/FGFR1/HSPG2/THBS1/CTTN/IQGAP1/ANK1/MAP2K2/FGF2	3.1970067994835
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/904	56/9376	2.40771175726928	OSTC/DAD1/MAN1A2/DDOST/B4GALT1/TMEM258/STT3B/ALG9/STT3A/SRD5A3/MAN2A1/RPN2/TUSC3	3.45125202992255
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	25/904	144/9376	1.80063913470993	PSMA7/SLC25A6/PSMD14/PSMA4/VDAC1/PSMD11/VDAC2/SLC25A5/PSMB2/AKT1/PSMA1/PSMB5/PSMB3/PSMC4/TBPL1/NOP56/ATXN10/PSMB6/PSMC1/DAB1/PSMD4/PSMD13/NRBF2/PSMC3/PSMD3	3.16262021347314
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/904	51/9376	2.44039562727746	ACTB/ACTG1/GNAS/PDIA4/KDELR2/KDELR1/SEC61G/SEC61B/KDELR3/ATP6V0A4/SEC61A1/ATP6V1B1	3.36914220402677
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/904	200/9376	1.65946902654867	GAPDH/RPS3/ACTB/ACTG1/TUBA1B/TUBB/TUBA1C/MYO10/TUBB6/TUBB4B/NCL/CLDN10/ITGB1/MYO1B/CLDN6/MYH10/RAC1/FYN/CDC42/TMED10/CLDN19/BAIAP2L1/CLDN3/ACTR3/ARPC2/ARPC3/MYH9/CTTN/PAK3/CYFIP2/ARPC4/ARPC1A	3.07935371712457
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	28/904	170/9376	1.70827693909422	ACTB/ACTG1/TUBA1B/TUBA1C/ACTN1/MYL6/JAM3/MYL9/CLDN10/ITGB1/CLDN6/MYH10/RAC1/CDC42/ACTN4/CLDN19/VASP/CLDN3/ACTR3/ARPC2/ARPC3/MYH9/MYL6B/RAB8B/CTTN/ARPC4/ARPC1A/PARD3	3.04417038796337
Genetic Information Processing	Transcription	hsa03040	Spliceosome	37/904	243/9376	1.57922721147893	HNRNPA1/SNRPD2/HNRNPA3/SRSF9/SNRPF/SNRPD1/SNRPG/RBM8A/SNRPB/SNRPE/HNRNPU/LSM5/ALYREF/U2AF1/RBMX/LSM2/HNRNPM/THOC3/SRSF3/LSM7/HNRNPC/SNRPA/PPIL1/SRSF7/HNRNPK/SNRPD3/SRSF2/LSM4/SRSF6/SF3B5/RBM25/EIF4A3/DDX46/SNRNP40/PPIH/HNRNPA1L2/TCERG1	2.98828657835702
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/904	205/9376	1.61899417224261	GAPDH/COL1A1/MMP2/COL3A1/COL1A2/UQCRH/SLC25A6/NDUFA4/NDUFB11/COX7C/COX5A/PPP1CA/PARP1/VDAC1/RAC1/GYS1/COX6C/COX8C/COX5B/PDK3/VDAC2/SLC25A5/AKT1/REN/SDHA/NDUFA4L2/COX7A1/PPP1CB/UQCRFS1/NDUFA3/NDUFS4/SDHC	2.92706268945687
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	64/904	480/9376	1.38289085545723	GPX3/RPS27A/TUBA1B/TUBB/HSPA5/TUBA1C/UBA52/UQCRH/TUBB6/CALM3/PSMA7/SLC25A6/DKK1/TUBB4B/NDUFA4/GPX8/HSD17B10/CTNNB1/NDUFB11/COX7C/PSMD14/COX5A/BRAF/APP/VCP/PSMA4/VDAC1/RAC1/COX6C/COX8C/COX5B/PSMD11/VDAC2/SLC25A5/PSMB2/MAP1LC3A/PSMA1/PSMB5/TOMM40/SDHA/NDUFA4L2/COX7A1/PPP3CA/PSMB3/TNFRSF1B/CSNK1E/PSMC4/AXIN2/UQCRFS1/NDUFA3/AXIN1/PSMB6/PSMC1/UBE2L3/PSMD4/PSMD13/NRBF2/HAP1/MAP2K2/NDUFS4/PSMC3/PSMD3/LRP6/SDHC	2.8130348056398
NA	NA	hsa04517	IgSF CAM signaling	43/904	299/9376	1.49157960162193	ACTB/ACTG1/TUBA1B/TUBB/TUBA1C/TUBB6/ACTN1/MYL6/JAM3/TUBB4B/MYL9/CTNNB1/ITGB1/PTPRS/APP/GRB2/MYH10/RAC1/FYN/CDC42/CDH1/ACTN4/PXN/SPTBN1/DYNLL1/AKT1/ACTR3/ARPC2/CNTNAP2/ARPC3/MYH9/MYL6B/CLMP/VCL/FGFR1/MTSS1/ROBO1/PAK3/IQGAP1/ARPC4/ARPC1A/MAP2K2/PARD3	2.82185802585088
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	19/904	106/9376	1.85907497077976	CCNE1/HSP90B1/HSP90AB1/TCF7L2/CTNNB1/BRAF/SLC19A1/GRB2/CDK2/IGF1/AKT1/ZEB1/PDGFRB/IL1R2/FGFR1/PDGFRA/E2F1/MAP2K2/MMP3	2.90550088101026
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/904	50/9376	2.28176991150442	ARG2/SRM/ALDH7A1/ODC1/CKMT1A/CKB/GAMT/P4HA1/ALDH1B1/P4HA2/SAT2	2.96841248237376
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/904	31/9376	2.67656294604625	ALDOA/PFKP/RPIA/TALDO1/TKT/PRPS2/GPI/ALDOC	3.05413294290605
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/904	31/9376	2.67656294604625	ACAT2/GCSH/MDH2/GLDC/PCCA/PGP/AGXT/SHMT1	3.05413294290605
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	49/904	362/9376	1.40390162812301	RPS6/COL1A1/CCNE1/COL6A2/COL1A2/COL4A1/COL4A2/LAMA4/COL6A3/HSP90B1/HSP90AB1/COL6A1/YWHAQ/EFNA1/PGF/ITGB1/LAMB1/GRB2/RAC1/GYS1/YWHAB/EIF4B/EIF4EBP1/ITGA1/CDK2/YWHAE/COL9A3/IGF1/CDC37/AKT1/BRCA1/MYC/FLT4/ANGPT4/PDGFRB/CCND2/FGFR1/FGFR3/PDGFRA/IFNAR2/THBS1/EFNA3/GNB5/GNB2/MAP2K2/FGF7/LPAR3/FGF2/GNG7	2.56004731526663
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/904	59/9376	2.10949452527374	GPX3/RRM2/IDH2/SRM/MGST1/MGST3/ODC1/GSTA4/GPX8/GGCT/IDH1/PRDX6	2.79247955118661
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/904	89/9376	1.86457193994233	COL1A1/COL6A2/COL1A2/COL4A1/COL4A2/LAMA4/HMMR/COL6A3/COL6A1/ITGB1/LAMB1/ITGA1/COL9A3/SDC4/HSPG2/THBS1	2.67691940948168
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/904	128/9376	1.70160398230089	RRM2/IMPDH2/NME1/PAICS/ADA/PDE4D/AK5/APRT/NME2/ADCY5/PRPS2/AK4/PNP/NME1-NME2/ENPP1/GMPS/HDDC2/PDE6H/NPR1/AK2/ATIC	2.61065810370871
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/904	15/9376	3.45722713864307	ALPL/AK5/ACP1/AK4/AK2	3.11104784353749
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/904	47/9376	2.20674072679345	LDHA/LDHB/PKM/ACAT2/ALDH7A1/ADH5/GLO1/MDH2/ALDH1B1/ACACA	2.70908251015858
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/904	224/9376	1.48166877370417	HLA-G/CCNE1/CALR/PTTG1/CDC20/RAN/MAD2L1/CCNB2/RANBP1/SLC25A6/CCNA2/FDPS/CHEK1/VDAC1/EGR1/CDK2/VDAC2/SLC25A5/MAD1L1/ADCY5/AKT1/MYC/ANAPC11/PPP3CA/NFYB/IL1R2/CCND2/TBPL1/CHEK2/E2F1/BUB1B/MAP2K2	2.38336948976034
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/904	63/9376	1.9755583649389	CDK7/POLR2L/RPA3/POLD2/LIG1/POLR2H/POLE2/RFC5/RFC3/RFC4/POLR2I/POLR2E	2.53778958238691
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/904	35/9376	2.37067003792668	TPI1/AKR1B1/ALDOA/PFKP/HK1/PMM1/KHK/ALDOC	2.65367134880904
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/904	142/9376	1.60688021936931	MMP2/ACTB/ACTG1/CAV1/MGST1/HSP90B1/CALM3/HSP90AB1/MGST3/GSTA4/TXN2/RAC3/CTNNB1/CAV2/GPC1/RAC1/BMP4/CDH5/AKT1/SDC4/IL1R2/SUMO2	2.38028576468488
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/904	103/9376	1.7118309133087	COL1A1/COL3A1/COL6A2/COL1A2/COL4A1/COL4A2/COL6A3/COL6A1/COL27A1/COL21A1/COL5A2/COL5A1/COL14A1/COL18A1/COL9A3/DPP4/SLC6A19	2.37280586368635
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/904	23/9376	2.70565602154675	ACAT2/FDPS/HMGCS1/HMGCR/MVD/IDI1	2.67520324479857
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/904	36/9376	2.30481809242871	PYGL/UGP2/GYS1/HK1/GYG2/GPI/ENPP1/GBE1	2.56215065105518
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/904	30/9376	2.42005899705015	TYMS/GGH/SLC19A1/ABCG2/DHFR/SHMT1/ATIC	2.54466728626574
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/904	89/9376	1.74803619369593	TUBA1B/TUBB/GNAS/TUBA1C/TUBB6/CDK1/TUBB4B/GNAI1/GRB2/ADCY5/GJA1/PDGFRB/GNAI3/PDGFRA/MAP2K2	2.31609714980226
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/904	37/9376	2.24252571155226	UGP2/GNPNAT1/HK1/NANS/PMM1/GPI/PGM3/NAGK	2.47361974313654
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/904	37/9376	2.24252571155226	PPARG/TCF7L2/CTNNB1/BRAF/CDH1/MYC/MAP2K2/GADD45A	2.47361974313654
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/904	59/9376	1.93370331483426	RRM2/TK1/TYMS/NME1/NME2/DUT/DTYMK/NME1-NME2/UMPS/ENPP1/HDDC2	2.35003179750394
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/904	59/9376	1.93370331483426	TCF7L2/CTNNB1/BRAF/GRB2/CDH1/AKT1/MYC/AXIN2/AXIN1/MAP2K2/GADD45A	2.35003179750394
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/904	157/9376	1.51941829660109	ACTB/ACTG1/BIRC5/YWHAQ/TCF7L2/CTNNB1/ID1/PPP1CA/YWHAB/CDH1/YWHAE/BMP4/TEAD1/MYC/TEAD4/PPP1CB/CSNK1E/CCND2/AXIN2/AXIN1/BMP7/SNAI2/PARD3	2.14388774756752
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/904	13/9376	3.19128658951668	FEN1/XRCC5/XRCC6/PRKDC	2.58249937593733
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/904	54/9376	1.92068174369059	LDHA/LDHB/SRM/CBS/DNMT1/MDH2/CTH/PHGDH/MTAP/CISD1	2.21630099820989
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/904	134/9376	1.54801215163122	CALD1/GNAS/PLA2G2A/MYL6/RAMP1/CALM3/MYL9/ACTA2/BRAF/PPP1CA/MYH10/PLA2G10/RAMP2/ADCY5/PPP1R14A/MYH9/PPP1CB/MYL6B/NPR1/MAP2K2	2.08706745370146
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/904	93/9376	1.6728518412789	CCNE1/COL4A1/SKP2/COL4A2/LAMA4/CKS1B/CKS2/ITGB1/LAMB1/CDK2/AKT1/MYC/TRAF4/E2F1/GADD45A	2.13006876575043
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/904	110/9376	1.60289621882542	GAPDH/RPS6/LDHA/ENO1/LDHB/TIMP1/ALDOA/PGK1/EIF4EBP1/PFKP/EGLN3/HK1/IGF1/AKT1/ANGPT4/ALDOC/MAP2K2	2.07763682654503
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/904	63/9376	1.81092850119399	ACAT2/ALDH7A1/PLOD1/EZH2/DHTKD1/AADAT/SMYD2/ECHS1/ALDH1B1/SUV39H2/AASS	2.10952617121953
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/904	87/9376	1.66900620486217	BIRC5/TCF7L2/RAC3/CTNNB1/BRAF/GRB2/RAC1/AKT1/MYC/AXIN2/MSH2/AXIN1/MAP2K2/GADD45A	2.0477746880873
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	22/904	154/9376	1.48166877370417	ALPL/NME1/ALAS2/UGP2/GGH/VKORC1/AK5/MTHFD1L/DHFR/HMBS/GCH1/NME2/PMM1/AK4/ALDH1B1/RDH11/MTHFD2/NME1-NME2/UMPS/MTHFD1/SHMT1/AK2	1.968671134568
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/904	41/9376	2.02374271530326	RAD51/RAD51C/RPA3/SSBP1/POLD2/XRCC2/BRCA1/RAD54L	2.14586537189032
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/904	41/9376	2.02374271530326	MMP2/BRAF/CDH1/MYC/FGFR3/THBS1/E2F1/MAP2K2	2.14586537189032
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/904	27/9376	2.30481809242871	SCD/ELOVL6/HSD17B12/ELOVL2/FADS2/FADS1	2.2178192669505
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/904	57/9376	1.81959323086477	ACAT2/SCD/ELOVL6/HSD17B12/ECHS1/FASN/ELOVL2/FADS2/FADS1/ACACA	2.02734665435369
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/904	73/9376	1.70493393138562	BRAF/CDH1/IGF1/AKT1/PDGFRB/FGFR1/PDGFRA/E2F1/MAP2K2/FGF7/GADD45A/FGF2	1.97503690401697
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/904	28/9376	2.22250316055626	ALPL/AKR1B1/GGH/DHFR/GCH1/TH	2.11615041681017
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/904	38/9376	1.91057289240801	UGP2/GNPNAT1/HK1/PMM1/GPI/PGM3/NAGK	1.83720010131002
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/904	103/9376	1.51043904115474	COL1A1/COL3A1/GNAS/COL1A2/COL4A1/COL4A2/LAMA4/ARG2/ACTN1/SERPINB9/LAMB1/ACTN4/SERPINB6/IL1R2/VCL	1.70148939482928
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/904	78/9376	1.59564329475834	ENO1/HSPD1/LSM5/LSM2/PABPC4/PFKP/PABPC1/LSM7/EXOSC8/LSM4/EXOSC5/PNPT1	1.72550279673083
NA	NA	hsa04981	Folate transport and metabolism	6/904	31/9376	2.00742220953468	TYMS/SLC19A1/ABCG2/DHFR/MTHFD1/SHMT1	1.83518391886863
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/904	87/9376	1.54979147594344	TPM1/TPM2/UQCRH/TPM4/MYL4/COX7C/COX5A/COX6C/COX8C/COX5B/COX7A1/UQCRFS1/MYL3	1.68286790164389
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/904	130/9376	1.43607896528251	COL1A1/MMP2/COL3A1/GNAS/COL1A2/COL4A1/COL4A2/ACTA2/GNAI1/GRB2/ADCY5/AKT1/RLN2/GNAI3/GNB5/GNB2/MAP2K2/GNG7	1.63544803761049
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	20/904	148/9376	1.40157856972016	TCF7L2/CTNNB1/BRAF/GRB2/HEY1/IGF1/AKT1/BRCA1/MYC/FLT4/AXIN2/PGR/FGFR1/AXIN1/E2F1/MAP2K2/FGF7/GADD45A/FGF2/LRP6	1.60851262232548
NA	NA	hsa03272	Virion - Hepatitis viruses	8/904	48/9376	1.72861356932153	CLDN10/CLDN6/CLDN19/EPCAM/CLDN3/DPP4/HSPG2/LDLR	1.653105173061
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/904	133/9376	1.40368620666711	CCNB1/BNIP3/SKP2/CCNB2/BRAF/GRB2/CDK2/IGF1/AKT1/PRMT1/PLK1/CSNK1E/CCND2/HOMER1/PLK2/MAP2K2/PLK4/GADD45A	1.53158157931323
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/904	205/9376	1.31543276494712	HLA-G/CCNE1/PKM/SKP2/CDC20/ACTN1/CDK1/RANBP1/YWHAQ/CCNA2/CHEK1/GRB2/RAC1/YWHAB/CDK2/CDC42/ACTN4/YWHAE/PXN/MAD1L1/HNRNPK/CCND2/TBPL1/SND1/PSMC1/DDX3X	1.4915996284163
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/904	33/9376	1.88576025744167	IDH2/GPT2/DHTKD1/AADAT/IDH1/AGXT	1.66497173701656
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/904	82/9376	1.51780703647744	RRM2/TK1/MGST1/IMPDH2/NME1/MGST3/GSTA4/NME2/DUT/NME1-NME2/UMPS/GMPS	1.5383332239898
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	29/904	235/9376	1.2799096215402	RPS6/ACTB/ACTG1/GNAS/UQCRH/PPARG/NDUFA4/NDUFB11/COX7C/COX5A/GRB2/KDM1A/COX20/COX6C/COX8C/COX5B/ADCY5/SDHA/NDUFA4L2/COX7A1/SMARCA2/FGFR1/UQCRFS1/NDUFA3/COA4/NPR1/SMARCC1/NDUFS4/SDHC	1.41948819003319
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	28/904	227/9376	1.27932634205294	UQCRH/MGST1/MGST3/SLC25A6/NDUFA4/GSTA4/NDUFB11/COX7C/COX5A/BRAF/GRB2/VDAC1/RAC1/COX6C/COX8C/COX5B/VDAC2/SLC25A5/AKT1/ACP1/SDHA/NDUFA4L2/COX7A1/UQCRFS1/NDUFA3/MAP2K2/NDUFS4/SDHC	1.39160150174398
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	18/904	138/9376	1.35282801077337	UQCRH/NDUFA4/PPA1/NDUFB11/COX7C/COX5A/COX6C/COX8C/COX5B/SDHA/NDUFA4L2/COX7A1/UQCRFS1/NDUFA3/ATP6V0A4/NDUFS4/ATP6V1B1/SDHC	1.36392503287168
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	39/904	333/9376	1.21470142709081	HLA-G/COL1A1/CCNE1/GNAS/COL6A2/COL1A2/COL4A1/PKM/COL4A2/LAMA4/COL6A3/COL6A1/CCNA2/TCF7L2/CTNNB1/ITGB1/LAMB1/GRB2/HEY1/EIF4EBP1/ITGA1/CDK2/CDC42/PXN/COL9A3/AKT1/PDGFRB/CCND2/AXIN2/TBPL1/IFNAR2/AXIN1/THBS1/E2F1/PSMC1/ATP6V0A4/MAP2K2/PARD3/ATP6V1B1	1.30309975268853
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	23/904	184/9376	1.29646017699115	MYL9/EFNA1/EPHB4/CFL1/RAC3/ITGB1/GNAI1/ENAH/RAC1/FYN/CDC42/SEMA6A/CXCL12/PPP3CA/GNAI3/SEMA5A/EFNA3/BMP7/ROBO1/SEMA4B/EPHB3/PAK3/PARD3	1.32662185329407
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	20/904	157/9376	1.32123330139226	LEP/UQCRH/PPARG/NDUFA4/NDUFB11/COX7C/COX5A/RAC1/COX6C/COX8C/COX5B/CDC42/AKT1/SDHA/NDUFA4L2/COX7A1/UQCRFS1/NDUFA3/NDUFS4/SDHC	1.32588348056292
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/904	52/9376	1.59564329475834	GNAS/CYP2J2/CGA/IGF1/ADCY5/LHB/LDLR/HSD17B7	1.40690144765916
NA	NA	hsa04519	Cadherin signaling	46/904	404/9376	1.1809340226058	ACTB/ACTG1/KRT19/ACTN1/LIMA1/DSC2/DSP/YWHAQ/TCF7L2/RAC3/CTNNB1/KRT7/MYO1B/PPP1CA/KRT18/ENAH/RAC1/YWHAB/CDC42/CDH1/ACTN4/YWHAE/VASP/CDH5/TEAD1/KRT10/ACTR3/FLT4/ARPC2/ARPC3/GJA1/TEAD4/PDGFRB/PPP1CB/VCL/KRT24/AXIN2/FGFR1/PDGFRA/AXIN1/DSC3/CYFIP2/ARPC4/ARPC1A/MAP2K2/LRP6	1.21434801910622
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	30/904	253/9376	1.22984364615761	ACTB/RPS27A/ACTG1/UBA52/BNIP3/PFN1/ACTN1/MYL9/ITGB1/U2AF1/VDAC1/RAC1/CDC42/ACTN4/PXN/UBE2N/HK1/CBX3/PLCD4/MAP1LC3A/AKT1/ACTR3/ARPC2/ARPC3/VCL/CTTN/GLMN/ARPC4/ARPC1A/TIFA	1.21060037909746
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/904	54/9376	1.53654539495247	UBE2T/RAD51/RAD51C/RPA3/FANCI/BRCA1/FANCD2/FANCB	1.29159299895678
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/904	80/9376	1.42610619469027	RPS6/BRAF/GRB2/EIF4EBP1/IGF1/AKT1/PDGFRB/FGFR3/PDGFRA/MAP2K2/FGF2	1.25023503207258
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/904	14/9376	2.22250316055626	B3GNT7/B4GALT4/B4GALT1	1.49522506929977
Organismal Systems	Immune system	hsa04611	Platelet activation	16/904	126/9376	1.31703890995926	COL1A1/ACTB/ACTG1/COL3A1/GNAS/COL1A2/ITGB1/GNAI1/PPP1CA/FYN/VASP/ADCY5/AKT1/PPP1CB/RASGRP2/GNAI3	1.17031791241225
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/904	30/9376	1.72861356932153	IDH2/MDH2/IDH1/SDHA/SDHC	1.30563527151566
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	29/904	248/9376	1.21281758492721	GAPDH/RPS3/ACTB/ACTG1/TUBA1B/TUBB/TUBA1C/TUBB6/PFN1/HSP90B1/HSP90AB1/TUBB4B/TCF7L2/MYL9/TXN2/CTNNB1/RAC1/CDC42/DYNLL1/AKT1/ACTR3/MYC/ARPC2/ARPC3/PAK3/CYFIP2/ARPC4/ARPC1A/MAP2K2	1.10948750366437
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/904	48/9376	1.51253687315634	ACAT2/ALDH7A1/HSD17B10/HMGCS1/PCCA/ECHS1/ALDH1B1	1.16286244461275
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/904	140/9376	1.25941845764855	RPS6/CALM3/MYL4/ACTA2/GNAI1/EGR1/CDH1/MAP1LC3A/ADCY5/AKT1/GNAI3/TFAM/GNB5/MYL3/GNB2/MAP2K2/GNG7	1.01018242521795
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/904	32/9376	1.62057522123894	AKR1B1/UGP2/PFKP/HK1/B4GALT1	1.14862928567976
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/904	32/9376	1.62057522123894	LDHA/LDHB/PCCA/ECHS1/ACACA	1.14862928567976
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/904	76/9376	1.36469492314858	CALM3/BRAF/GRB2/IGF1/AKT1/PDGFRB/PDGFRA/E2F1/MAP2K2/GADD45A	1.04273012179197
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/904	24/9376	1.72861356932153	HS6ST1/EXT1/XYLT1/EXTL2	1.16742101459479
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/904	86/9376	1.32661041366536	ACTB/ACTG1/DSC2/DSP/TCF7L2/CTNNB1/ITGB1/ITGA1/GJA1/SSPN/SGCB	0.993912782954381
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/904	68/9376	1.37272254034357	CCNA2/TCF7L2/BRAF/GRB2/EIF4EBP1/AKT1/MYC/MAP2K2/RUNX1T1	1.00760150238059
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/904	105/9376	1.28411293721028	TPM1/ACTB/ACTG1/GNAS/TPM2/TPM4/ITGB1/ITGA1/IGF1/ADCY5/SSPN/MYL3/SGCB	0.956311214826213
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	27/904	238/9376	1.17661932029449	PLA2G2A/CALM3/EFNA1/RAC3/PGF/GRB2/RAC1/RALBP1/CDC42/PLA2G10/IGF1/AKT1/FLT4/ANGPT4/PDGFRB/RASGRP2/FGFR1/FGFR3/PDGFRA/EFNA3/GNB5/PAK3/GNB2/MAP2K2/FGF7/FGF2/GNG7	0.901525448561572
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/904	42/9376	1.48166877370417	ACAT2/ALDH7A1/DHTKD1/AADAT/ECHS1/ALDH1B1	1.02191816503135
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/904	115/9376	1.26263947672182	NACA/GNAS/GCM1/MMP15/GNAI1/PDE4D/BRAF/MMP14/PTH1R/EGR1/ADCY5/GNAI3/FGFR1/LRP6	0.925671435478338
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/904	34/9376	1.52524726704841	POLR2L/POLR1D/POLR2H/POLR2I/POLR2E	1.00221340731422
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/904	107/9376	1.26011082623439	LDHA/LDHB/GNAS/PYGL/PKM/CALM3/GYS1/PFKP/PGAM1/AKT1/PRMT1/PPP3CA/ACACA	0.883915513591737
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/904	70/9376	1.33350189633375	HLA-G/ACTB/ACTG1/CAV1/RAC3/RAC1/FYN/SSPN/SGCB	0.914834814425015
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/904	52/9376	1.39618788291355	VDAC1/APOA2/PLTP/VDAC2/LIPG/LRP2/LDLR	0.935790448614434
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/904	98/9376	1.27000180603215	MYO10/CFL1/RAC1/CDC42/VASP/AKT1/ACTR3/ARPC2/ARPC3/MARCKSL1/ARPC4/ARPC1A	0.877666259262646
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/904	155/9376	1.20445332572081	HLA-G/CALR/ACTB/ACTG1/TUBA1B/TUBB/TUBA1C/TUBB6/C1R/TUBB4B/ITGB1/SEC61G/SEC61B/RAC1/THBS1/ATP6V0A4/SEC61A1/ATP6V1B1	0.838393489804866
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/904	156/9376	1.19673247106875	YWHAQ/CLDN10/EIF3E/CTNNB1/CLDN6/BRAF/GRB2/YWHAB/CDK2/YWHAE/CLDN19/CLDN3/AKT1/MYC/IFNAR2/E2F1/LDLR/MAP2K2	0.809374962248332
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/904	214/9376	1.16317922421636	HLA-G/CALR/CCNB1/PDIA3/CDK1/CCNB2/CALM3/WEE1/CFL1/RAC3/GNAI1/CHEK1/RAC1/PXN/AKT1/PPP3CA/TNFRSF1B/GNAI3/GNB5/PAK3/CDC25C/GNB2/MAP2K2/GNG7	0.788775634978848
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	19/904	166/9376	1.18712016206419	CALM3/SLC25A6/MYL9/GNAI1/PPP1CA/VDAC1/ATP2B4/VDAC2/VASP/SLC25A5/ADCY5/AKT1/ADRA2C/PPP3CA/PPP1CB/GNAI3/ATP2B3/NPR1/MAP2K2	0.794550844800085
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/904	138/9376	1.20251378735411	RPS6/PYGL/CALM3/CBLB/BRAF/PPP1CA/GRB2/GYS1/EIF4EBP1/HK1/AKT1/SH2B2/PPP1CB/FASN/MAP2K2/ACACA	0.782856280226965
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/904	139/9376	1.19386260902782	MMP2/GNAS/KRT19/HSP90B1/CALM3/HSP90AB1/GNAI1/KRT18/GRB2/ADCY5/AKT1/KRT10/KRT24/GNAI3/PGR/MAP2K2	0.75216455077063
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/904	178/9376	1.16535746246396	NOTUM/SERPINF1/DKK1/TCF7L2/APCDD1/RAC3/CTNNB1/RAC1/MYC/PPP3CA/CSNK1E/CCND2/AXIN2/RUVBL1/AXIN1/CACYBP/SFRP1/RSPO3/LGR5/LRP6	0.727551897158345
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/904	19/9376	1.6376339077783	GCSH/DHTKD1/GLDC	0.908775832916429
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/904	150/9376	1.17545722713864	CCNE1/TCF7L2/CTNNB1/BRAF/GRB2/CDK2/CDH1/AKT1/MYC/AXIN2/AXIN1/E2F1/MAP2K2/FGF7/GADD45A/FGF2/LRP6	0.707598731891384
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/904	28/9376	1.48166877370417	ELOVL6/HSD17B12/ECHS1/ELOVL2	0.833767640956229
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	19/904	170/9376	1.15918792295679	ACTB/ACTG1/MGST1/MGST3/TCF7L2/GSTA4/CTNNB1/BRAF/GRB2/AKT1/MYC/SMARCA2/AXIN2/AXIN1/E2F1/SMARCC1/MAP2K2/GADD45A/LRP6	0.684188817168307
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/904	93/9376	1.22675801693786	MMP2/GNAS/CALM3/CGA/GRB2/MMP14/EGR1/CDC42/ADCY5/LHB/MAP2K2	0.717855164585388
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/904	122/9376	1.19019294936893	LEP/EEF2/PPARG/SCD/CCNA2/GYS1/EIF4EBP1/PFKP/IGF1/AKT1/HMGCR/CAB39L/FASN/ACACA	0.690695236516286
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/904	75/9376	1.2446017699115	GPX3/GNAS/HSPA5/PDIA4/HSP90B1/CGA/GPX8/ADCY5/LRP2	0.694707975265777
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/904	76/9376	1.22822543083372	PPARG/SCD/DBI/APOA2/PLTP/HMGCS1/SLC27A2/FADS2/SLC27A6	0.652538645821284
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/904	76/9376	1.22822543083372	ACTB/ACTG1/GNAS/CALM3/CA2/GNAI1/GAST/ADCY5/GNAI3	0.652538645821284
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/904	144/9376	1.15240904621436	CTNNB1/ID1/ID3/GRB2/DLX5/BMP4/IGF1/AKT1/MYC/AXIN2/FGFR1/FGFR3/AXIN1/MAP2K2/MEIS1/FGF2	0.602033936860101
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/904	77/9376	1.2122744512125	RAD51/RAC3/BRAF/RAC1/RALBP1/CDC42/AKT1/E2F1/GADD45A	0.610944620923776
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/904	205/9376	1.11305849341679	HLA-G/CCNE1/CALR/PDIA3/SKP2/CCNA2/PSMD14/RAC1/CDK2/PSMD11/AKT1/MYC/PSMC4/CCND2/IFNAR2/E2F1/PSMC1/PSMD4/PSMD13/GADD45A/PSMC3/PSMD3	0.534624254389256
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/904	21/9376	1.48166877370417	DSEL/XYLT1/CHSY1	0.721793760509792
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/904	59/9376	1.23053847307635	GNAS/CGA/GNAI1/ADCY5/AKT1/GNAI3/NPR1	0.580240782773263
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/904	69/9376	1.20251378735411	GNAS/CALM3/GNAI1/ADCY5/REN/PPP3CA/GNAI3/NPR1	0.551507171430092
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/904	108/9376	1.15240904621436	RAN/KPNA2/RBM8A/ALYREF/THOC3/KPNB1/PNN/NUP37/EIF4A3/SUMO2/SEC13/IPO5	0.520363097649969
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/904	217/9376	1.09930263855471	GNAS/BIRC5/KPNA2/MGST1/HSP90B1/HSP90AB1/MGST3/CDC6/GSTA4/GNAI1/GRB2/EIF4EBP1/KPNB1/ADCY5/AKT1/MYC/GNAI3/PGR/E2F1/CDC25A/MAP2K2/FGF7/FGF2	0.48344102887562
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/904	227/9376	1.09656543604538	HLA-G/CALR/GNAS/PDIA3/CALM3/RAC3/CTNNB1/GNAI1/GRB2/RAC1/EIF4EBP1/PXN/CXCL12/ADCY5/AKT1/MYC/PPP3CA/GNAI3/PDGFRA/E2F1/GNB5/GNB2/MAP2K2/GNG7	0.481088195369134
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/904	50/9376	1.2446017699115	HBA2/HBA1/GYPA/GYPB/GYPC/THBS1	0.566465900392231
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/904	99/9376	1.15240904621436	TPM1/ACTB/ACTG1/TPM2/TPM4/ITGB1/ITGA1/IGF1/SSPN/MYL3/SGCB	0.497968010027227
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/904	60/9376	1.21002949852507	RAC3/RAC1/CDC42/PXN/AKT1/PPP3CA/MAP2K2	0.533111511765535
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/904	70/9376	1.18533501896334	BRAF/GRB2/RAC1/CDC42/EGLN3/AKT1/PAK3/MAP2K2	0.50839569292914
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/904	71/9376	1.16864015954132	CGA/GRB2/AKT1/LHB/CCND2/ELF5/TH/MAP2K2	0.465917335778402
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/904	101/9376	1.1295890651012	COL1A1/MMP2/COL3A1/COL1A2/COL4A1/COL4A2/EGR1/RAC1/CDC42/PLCD4/AKT1	0.42770956671414
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/904	23/9376	1.35282801077337	ARG2/GPT2/ASL	0.553386279151881
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/904	43/9376	1.20600946696851	ACAT2/ALDH7A1/ADH5/ECHS1/ALDH1B1	0.442270174972125
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/904	103/9376	1.10765529684681	RBM8A/ALYREF/PPP1CA/PAPOLA/PABPC4/PNN/PABPC1/PPP1CB/EIF4A3/MSI2/GSPT1	0.358856457115147
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/904	154/9376	1.07757728996667	ACTB/ACTG1/GNAS/EEF2/MYL6/CALM3/MYL9/GNAI1/PPP1CA/ADCY5/PPP3CA/PPP1CB/MYL6B/GNAI3/NPR1/MAP2K2	0.317073017378525
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/904	155/9376	1.0706251784185	CCNE1/GNAS/TCF7L2/CTNNB1/GNAI1/BRAF/CDK2/ADCY5/GNAI3/AXIN2/PBX1/AXIN1/E2F1/WDR5/LDLR/MAP2K2	0.289609814825082
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/904	105/9376	1.08655710071639	RPS27A/UBA52/BNIP3/TOMM20/VCP/PHB2/CITED2/MAP1LC3A/TOMM40/TOMM7/E2F1	0.291347261235989
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/904	75/9376	1.10631268436578	BIRC5/TOP2A/MGST1/MGST3/GSTA4/AKT1/BRCA1/MSH2	0.301944952105386
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/904	138/9376	1.05219956393485	ACTB/ACTG1/RAC3/ITGB1/RAC1/CDC42/PXN/AKT1/ACTR3/ARPC2/ARPC3/ARPC4/ARPC1A/MAP2K2	0.201787527582251
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/904	36/9376	1.15240904621436	GALNT2/GALNT1/GCNT1/C1GALT1	0.29927155306221
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/904	26/9376	1.19673247106875	PLA2G2A/PLA2G10/FADS2	0.328120825429649
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/904	27/9376	1.15240904621436	ACAT2/HMGCS1/ECHS1	0.259051986719916
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/904	110/9376	1.03716814159292	DCN/ID1/ID3/LRRC32/GREM2/BMP4/MYC/TFDP1/E2F5/THBS1/BMP7	0.12808489643232
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	19/904	193/9376	1.02104635700857	CCR7/CXCL14/RAC3/GNAI1/BRAF/GRB2/RAC1/CDC42/PXN/CXCL12/ADCY5/AKT1/RASGRP2/GNAI3/GNB5/CCL21/GNB2/PARD3/GNG7	0.096502857957464
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/904	17/9376	1.22019781363873	CTH/SEPHS1	0.296824414255697
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/904	17/9376	1.22019781363873	MYH10/MYH9	0.296824414255697
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/904	69/9376	1.05219956393485	GNAS/CALM3/PPP1CA/ADCY5/PPP3CA/PPP1CB/TH	0.142155426708073
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/904	142/9376	1.02256013959865	RPS27A/UBE2C/UBE2S/UBA52/SKP2/CDC20/CBLB/UBE2N/BRCA1/ANAPC11/UBE2Q2/SAE1/UBE2L3/FBXW7	0.0884846423101178
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/904	28/9376	1.11125158027813	CA2/ATP6V0A4/ATP6V1B1	0.19257625302926
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/904	122/9376	1.02016538517336	ACTB/ACTG1/DIO2/DIO3/CTNNB1/PFKP/BMP4/PLCD4/AKT1/MYC/MED30/MAP2K2	0.0732316078381113
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/904	49/9376	1.05833483836012	GNAS/GNAI1/ADCY5/GNAI3/TH	0.133730950176927
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/904	133/9376	1.0137733714818	GNAS/CALM3/GNAI1/PPP1CA/ADCY5/AKT1/PPP3CA/PPP1CB/GNAI3/TH/GNB5/GNB2/GNG7	0.0522560387205931
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/904	154/9376	1.01022870934375	TPM1/GNAS/TPM2/TPM4/CALM3/MYL4/GNAI1/PPP1CA/ATP2B4/ADCY5/AKT1/PPP1CB/GNAI3/ATP2B3/MYL3	0.0418066645136131
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/904	60/9376	1.03716814159292	GNAS/GNAI1/BRAF/IGF1/GNAI3/MAP2K2	0.0943427675315414
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/904	18/9376	1.15240904621436	FASN/ACACA	0.211413325305787
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/904	29/9376	1.07293256026854	TEAD1/TEAD4/CSNK1E	0.128487599995758
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/904	30/9376	1.03716814159292	PLA2G2A/CYP2J2/PLA2G10	0.0666032567655762
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/904	63/9376	0.987779182469448	TCF7L2/CTNNB1/BMP4/AXIN2/AXIN1/GADD45A	-0.0317908846173738
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/904	160/9376	0.972345132743363	HLA-G/VCAN/JAM3/CLDN10/ITGB1/PTPRS/CLDN6/CDH1/CLDN19/CDH5/CD276/CLDN3/CNTNAP2/SDC4/NRXN3	-0.115249013430253
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/904	31/9376	1.00371110476734	ALDH7A1/ECHS1/ALDH1B1	0.00676038281249423
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/904	42/9376	0.987779182469448	SLC40A1/VDAC2/MAP1LC3A/SAT2	-0.0259279324461149
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/904	20/9376	1.03716814159292	UGP2/NANS	0.0543522613816045
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/904	53/9376	0.978460510936717	GNAS/RAB11A/PTH1R/ATP2B4/ATP2B3	-0.0513656005124244
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/904	86/9376	0.96480757357481	CBLB/BRAF/GRB2/EIF4EBP1/AKT1/MYC/PAK3/MAP2K2	-0.10709457207637
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/904	21/9376	0.987779182469448	ALDH1B1/ENPP1	-0.0183132275194962
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/904	77/9376	0.942880128720837	BRAF/GRB2/AKT1/MYC/E2F1/MAP2K2/GADD45A	-0.164396034975158
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/904	196/9376	0.952501354524111	HLA-G/RPS27A/UBA52/CALM3/TCF7L2/CTNNB1/RAC1/MAP1LC3A/AKT1/MYC/PPP3CA/IFNAR2/E2F1/GNB5/GNB2/MAP2K2/FGF2/GNG7	-0.219515302230547
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/904	99/9376	0.942880128720837	MMP2/GNAS/BRAF/GRB2/IGF1/ADCY5/AKT1/E2F1/MAP2K2	-0.186628480004339
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/904	78/9376	0.930791921942364	C1R/CALM3/CFL1/ITGB1/GNAI1/C1S/GNAI3	-0.200486991620154
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/904	89/9376	0.932285969971164	GNAI1/ADCY5/GNAI3/SLC6A11/GNB5/HAP1/GNB2/GNG7	-0.209658667953654
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/904	67/9376	0.928807290978734	CALM3/BRAF/PPP1CA/PPP3CA/PPP1CB/MAP2K2	-0.191028552594914
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/904	10/9376	1.03716814159292	SELENBP1	0.0384123298984015
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/904	22/9376	0.942880128720837	ALDH7A1/ALDH1B1	-0.0876146554865268
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/904	102/9376	0.915148360229047	GNAS/PLA2G2A/CA2/RAB11A/RAC1/ATP2B4/PLA2G10/ADCY5/ATP2B3	-0.281451559589559
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/904	91/9376	0.911796168433337	GNAS/GNAI1/PDE4D/ADCY5/GNAI3/GNB5/GNB2/GNG7	-0.276181175190013
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/904	157/9376	0.924863310974579	CALR/ARG2/PPARG/ODC1/RAC1/BSG/MFGE8/RAB17/PBX1/UQCRFS1/THBS1/TYRO3/SLC16A1/MAP2K2	-0.310125053446284
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/904	23/9376	0.901885340515583	B4GALT1/CHST10	-0.153886042730349
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/904	23/9376	0.901885340515583	ENPEP/REN	-0.153886042730349
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/904	69/9376	0.901885340515583	RAC3/GRB2/RAC1/FYN/AKT1/MAP2K2	-0.267196318013946
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/904	158/9376	0.919009745715246	RPS6/SKP2/BRAF/GRB2/EIF4B/EIF4EBP1/IGF1/AKT1/CAB39L/SLC38A9/MAP2K2/SEC13/LRP6/ATP6V1B1	-0.33536662011096
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/904	137/9376	0.908468445190879	ACTB/ACTG1/TUBA1B/TUBA1C/BIRC5/CTSV/LMNB1/PARP1/LMNB2/AKT1/MAP2K2/GADD45A	-0.352529544239589
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/904	115/9376	0.901885340515583	GNAS/CYP2J2/GNAI1/BRAF/APP/ADCY5/GNAI3/GNB5/GNB2/GNG7	-0.345804594267472
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/904	82/9376	0.885387437945176	HLA-G/CALR/HSPA5/PDIA3/HSPA2/HSP90AB1/NFYB	-0.340498100016083
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/904	36/9376	0.864306784660767	AKR1B1/UGP2/DCXR	-0.266448221436032
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/904	116/9376	0.894110466890449	GNAS/SLC1A2/GNAI1/ADCY5/PPP3CA/GNAI3/HOMER1/GNB5/GNB2/GNG7	-0.374846460678868
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/904	12/9376	0.864306784660767	VKORC1	-0.153636687123507
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/904	37/9376	0.840947141832098	GPT2/AGXT/ASL	-0.316642373279269
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/904	37/9376	0.840947141832098	HBA2/HBA1/LAMA4	-0.316642373279269
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/904	49/9376	0.846667870688098	GALNT2/GALNT1/B4GALT1/C1GALT1	-0.351509525387651
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/904	61/9376	0.850137820977804	SLC40A1/ATP2B4/SLC39A4/SLC6A19/ATP2B3	-0.383568037765912
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/904	163/9376	0.890819262717846	CCNE1/BIRC5/YWHAQ/CCNA2/BRAF/GRB2/YWHAB/CDK2/AKT1/MYC/HSPG2/E2F1/MAP2K2/DDX3X	-0.45932085991738
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/904	73/9376	0.852466965692811	BRAF/GRB2/AKT1/E2F1/MAP2K2/GADD45A	-0.413348222216448
NA	NA	hsa04081	Hormone signaling	19/904	219/9376	0.899826241564634	LEP/GNAS/DIO2/RAMP1/CGA/SLC40A1/GNAI1/PTH1R/GAST/RAMP2/IGF1/ADCY5/ADRA2C/LHB/GNAI3/GNB5/NPR1/GNB2/GNG7	-0.489977681847636
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/904	38/9376	0.818816953889148	NNMT/PNP/ENPP1	-0.365560531667314
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/904	97/9376	0.85539640543746	GNAS/CALM3/GNAI1/ADCY5/GNAI3/GNB5/GNB2/GNG7	-0.467618030549932
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/904	120/9376	0.864306784660767	CALM3/MAGED1/BRAF/GRB2/RAC1/CDC42/YWHAE/AKT1/SH2B2/MAP2K2	-0.488668070725949
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/904	51/9376	0.813465209092487	PLA2G2A/PLA2G10/PAFAH1B3/LPCAT1	-0.436312235794336
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/904	63/9376	0.82314931872454	PTGDS/PLA2G2A/CYP2J2/PLA2G10/PTGR1	-0.460054295784754
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/904	99/9376	0.838115669974077	RAC3/GRB2/RAC1/EIF4EBP1/AKT1/PDGFRB/PDGFRA/MAP2K2	-0.528926725020121
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/904	201/9376	0.87720688592436	PPARG/IGFBP3/CCNA2/NUPR1/MYCN/IGF1/MYC/ZEB1/IL1R2/CCND2/PBX1/TLX3/MLF1/MEIS1/GADD45A/RUNX1T1/MMP3	-0.574838550355996
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/904	191/9376	0.868831951072603	GNAS/CALM3/SLC29A1/GNAI1/BRAF/PPP1CA/GRB2/ADCY5/PPP1CB/GNAI3/TH/PKIA/GNB5/SLC29A2/GNB2/GNG7	-0.598249083314228
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/904	180/9376	0.864306784660767	HLA-G/CALR/PDIA3/SRSF9/ALYREF/PPP1CA/EIF4EBP1/SRSF3/EIF2B2/AKT1/SRSF7/SRSF2/PPP1CB/SRSF6/IFNAR2	-0.600442997870595
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/904	65/9376	0.79782164737917	CGA/AKT1/KISS1R/LHB/MAP2K2	-0.53428139152359
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/904	28/9376	0.740834386852086	B4GALT4/B4GALT1	-0.448615134897708
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/904	226/9376	0.871955517268384	GNAS/CALM3/MYL9/CGA/RAC3/GNAI1/PDE4D/BRAF/PPP1CA/RAC1/ATP2B4/ADCY5/AKT1/LHB/PPP1CB/GNAI3/ATP2B3/NPR1/MAP2K2	-0.636475106569204
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/904	101/9376	0.8215193200736	GNAS/CALM3/TCF7L2/CTNNB1/GNAI1/ADCY5/GNAI3/MAP2K2	-0.589076664906492
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/904	43/9376	0.723605680181107	PLA2G2A/ACAT2/PLA2G10	-0.593375469518046
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/904	56/9376	0.740834386852086	CSNK1E/GAS1/CCND2/LRP2	-0.635389911211606
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/904	56/9376	0.740834386852086	BNIP3/HSPD1/SAR1A/VCP	-0.635389911211606
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/904	117/9376	0.79782164737917	ACTB/ACTG1/RBBP7/MORF4L2/ACTR6/SMARCA2/RUVBL1/SMARCC1/RUVBL2	-0.718823757344428
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/904	44/9376	0.707160096540628	CDK7/TBPL1/TAF9	-0.635983880231784
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/904	44/9376	0.707160096540628	GNAS/RAB11A/DYNLL1	-0.635983880231784
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/904	323/9376	0.866982657059097	CCNE1/TPM1/STMN1/EFNA1/IGF2BP1/DNMT1/GRB2/EZH2/CDCA5/SOX4/KIF23/HNRNPK/BRCA1/MYC/ZEB1/FSCN1/PDGFRB/CCND2/FGFR3/PDGFRA/THBS1/EFNA3/E2F1/SLC7A1/CDC25C/CDC25A/MAP2K2	-0.794676095525103
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/904	31/9376	0.669140736511561	ALDH7A1/ALDH1B1	-0.602714129206216
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/904	17/9376	0.610098906819365	CA2	-0.525582709875927
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/904	83/9376	0.749760102356328	AURKB/RBBP7/EZH2/CBX3/TFDP1/WDR5	-0.747987794567804
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/904	71/9376	0.730400099713324	JAM3/RAC1/CDC42/ATP6V0A4/ATP6V1B1	-0.744847891565916
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/904	250/9376	0.829734513274336	HLA-G/CAV1/CBLB/RAB11A/CAV2/CDC42/ARF4/ACTR3/ARPC2/ARPC3/MVB12A/EHD3/FGFR3/PDGFRA/LDLR/PSD/ARPC4/ARPC1A/VPS28/PARD3	-0.891319229588614
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/904	122/9376	0.765124038880023	GNAS/IGFBP3/GNAI1/GRB2/IGF1/ADCY5/AKT1/GNAI3/MAP2K2	-0.852963835179151
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/904	98/9376	0.740834386852086	GNAS/CALM3/ATP2B4/ADCY5/LDLR/ATP2B3/NPR1	-0.84244219534575
NA	NA	hsa04382	Cornified envelope formation	17/904	217/9376	0.81252803719261	KRT19/COL4A1/COL4A2/DSP/CLDN10/PADI1/KRT7/CLDN6/KRT18/CLDN19/CLDN3/KRT10/CASP14/KRT24/S100A13/PRSS8/BLMH	-0.912681071762309
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/904	34/9376	0.610098906819365	RORB/CSNK1E	-0.743962182436421
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/904	99/9376	0.733351211227317	GNAS/CALM3/CYP2J2/PPP1CA/IGF1/ADCY5/PPP1CB	-0.871224970035904
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/904	99/9376	0.733351211227317	KRT19/C1R/CFD/KRT18/C1S/KRT10/KRT24	-0.871224970035904
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/904	300/9376	0.829734513274336	STMN1/EFNA1/RAC3/PGF/BRAF/GRB2/RAC1/CDC42/IGF1/AKT1/MYC/FLT4/ANGPT4/PPP3CA/PDGFRB/RASGRP2/FGFR1/FGFR3/PDGFRA/EFNA3/MAP2K2/FGF7/GADD45A/FGF2	-0.979077088838849
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/904	149/9376	0.765694601175982	NDUFA4/NDUFB11/GNAI1/ADCY5/NDUFA4L2/GNAI3/NDUFA3/GNB5/GNB2/NDUFS4/GNG7	-0.941720554000654
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/904	115/9376	0.721508272412466	GNAI1/FYN/ADCY5/AKT1/GNAI3/GNB5/GNB2/GNG7	-0.981542609140376
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/904	90/9376	0.691445427728614	GNAS/CA2/ABCG2/ADCY5/HMGCR/LDLR	-0.960761919750947
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/904	91/9376	0.683847126325002	RAC3/GRB2/RAC1/AKT1/PPP3CA/MAP2K2	-0.989928335769275
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/904	37/9376	0.560631427888065	ADH5/TH	-0.87469479656243
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/904	65/9376	0.638257317903336	ALDH7A1/AKR1B1/ALDH1B1/LIPG	-0.955949937561063
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/904	65/9376	0.638257317903336	GNAS/ADCY5/PBX1/LDLR	-0.955949937561063
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/904	79/9376	0.656435532653747	MGST1/MGST3/ADH5/GSTA4/AKR7A2	-1.00167596077029
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/904	79/9376	0.656435532653747	SLC1A2/CPLX1/SLC6A11/ATP6V0A4/ATP6V1B1	-1.00167596077029
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/904	66/9376	0.628586752480558	DHRS9/HSD17B12/SRD5A3/HSD17B7	-0.989079947715462
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/904	38/9376	0.545877969259432	IGF1/SFN	-0.916250689911649
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/904	38/9376	0.545877969259432	ADA/UNG	-0.916250689911649
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/904	144/9376	0.720255653883972	ALDH7A1/SCD/ADH5/TCF7L2/CTNNB1/LBP/AKT1/ALDH1B1/FASN/ACACA	-1.10502358088193
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/904	23/9376	0.450942670257791	CA2	-0.861158364612578
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/904	133/9376	0.701843103333555	HLA-G/RAC3/BRAF/GRB2/RAC1/FYN/PPP3CA/IFNAR2/MAP2K2	-1.13120439375351
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/904	109/9376	0.666071283591784	PYGL/PPP1CA/GYS1/AKT1/PPP1CB/SLC27A2/SLC27A6	-1.14544519678052
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/904	122/9376	0.680110256782243	CBLB/GRB2/FYN/CDC42/AKT1/PPP3CA/PAK3/MAP2K2	-1.16169564951824
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/904	83/9376	0.62480008529694	IDH2/FAR2/IDH1/SLC27A2/AGXT	-1.1215036425582
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/904	83/9376	0.62480008529694	POLR2L/POLR1D/POLR2H/G3BP1/POLR2E	-1.1215036425582
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/904	173/9376	0.719422988388153	ACTB/ACTG1/KPNA2/SLC25A6/FDPS/RAB11A/VDAC1/SLC25A5/AKT1/DNAJC3/IFNAR2/MAP2K2	-1.21671063947015
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/904	112/9376	0.648230088495575	LAMA4/ITGB1/LAMB1/GNAI1/AKT1/GNAI3/LDLR	-1.22333473613728
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/904	125/9376	0.663787610619469	DEGS2/RAC3/GNAI1/RAC1/FYN/AKT1/GNAI3/MAP2K2	-1.23609331872834
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/904	26/9376	0.398910823689585	SLC19A1	-1.00252833513626
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/904	73/9376	0.568311310461874	MGST1/MGST3/ADH5/GSTA4	-1.20947659762759
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/904	73/9376	0.568311310461874	PPIA/RAN/MAP1B/PSIP1	-1.20947659762759
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/904	44/9376	0.471440064360418	HLA-G/HSPD1	-1.14791595964913
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/904	216/9376	0.720255653883972	HSPA5/HSPA2/HSP90B1/CALM3/HSP90AB1/PPARG/HSPD1/CYP2J2/RAC1/CDC42/LBP/AKT1/PPP3CA/LDLR/MMP3	-1.35868048139901
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/904	88/9376	0.589300080450523	C1R/TFPI/CFD/C1S/PROCR	-1.26439197394263
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/904	142/9376	0.657360089741992	PPARG/FHL2/GRB2/RAC1/FYN/AKT1/PPP3CA/FOSL2/IFNAR2	-1.34389105917411
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/904	45/9376	0.460963618485742	ABCA7/ABCG2	-1.18396024621126
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/904	90/9376	0.576204523107178	PPARG/EIF4EBP1/IGF1/ADCY5/AKT1	-1.31959333146163
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/904	46/9376	0.450942670257791	ALAS2/HMBS	-1.21936203047789
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/904	62/9376	0.501855552383671	IGF1/ADCY5/AKT1	-1.28546395051089
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/904	29/9376	0.357644186756179	CALM3	-1.1316585690003
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/904	47/9376	0.44134814535869	PKM/HK1	-1.25415007140592
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/904	78/9376	0.53188109825278	TPI1/PLCD4/INPP4B/PPIP5K2	-1.35608086463075
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/904	93/9376	0.557617280426301	GNAS/CALM3/ATP2B4/ADCY5/ATP2B3	-1.40046523716218
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/904	48/9376	0.432153392330383	HK1/AKT1	-1.28835119762851
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/904	149/9376	0.626477400962167	GNAS/GRB2/FYN/ADCY5/AKT1/PDGFRB/PDGFRA/MAP2K2/LPAR3	-1.50126250040814
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/904	32/9376	0.324115044247788	BIRC5	-1.25100266230006
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/904	254/9376	0.694167653822033	GNAS/CALM3/SLC25A6/VDAC1/ATP2B4/VDAC2/SLC25A5/PLCD4/FLT4/PPP3CA/PDGFRB/FGFR1/FGFR3/PDGFRA/ATP2B3/FGF7/FGF2	-1.61410625556711
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/904	68/9376	0.457574180114524	DHRS9/ADH5/RDH11	-1.46636978419074
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/904	168/9376	0.617361989043405	HMGB1/PPIA/PYGL/HSP90AB1/SLC25A6/PARP1/VDAC1/VDAC2/SLC25A5/IFNAR2	-1.6346959089494
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/904	100/9376	0.51858407079646	CCR7/CXCL14/CXCL12/TNFRSF1B/CCL21	-1.58094574528491
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/904	70/9376	0.444500632111252	LEP/AKT1/TNFRSF1B	-1.52379991455023
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/904	70/9376	0.444500632111252	MGST1/MGST3/GSTA4	-1.52379991455023
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/904	143/9376	0.580233925366669	ACTN1/C1R/SNRPD1/SNRPB/C1S/ACTN4/SNRPD3/SSB	-1.65226923696764
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/904	54/9376	0.384136348738119	HLA-G/CGA	-1.48253099880256
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/904	103/9376	0.503479680384913	CALR/GNAS/GNAI1/AKT1/GNAI3	-1.65509294945605
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/904	105/9376	0.493889591234724	PARP1/CXCL12/LBP/CCL21/GADD45A	-1.70354459953468
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/904	39/9376	0.26594054912639	HLA-G	-1.50050255234121
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/904	136/9376	0.533836543466944	CCNE1/CBLB/EIF3H/CDK2/AKT1/CCND2/IFNAR2	-1.78874558066358
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/904	109/9376	0.47576520256556	RAC1/LBP/AKT1/IFNAR2/MAP2K2	-1.79823477646774
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/904	94/9376	0.44134814535869	HSP90B1/HSP90AB1/TRAF4/MMP3	-1.77812082984848
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/904	168/9376	0.555625790139064	LEP/GRB2/AKT1/MYC/PDGFRB/CCND2/PDGFRA/IFNAR2/CNTFR	-1.89844365196822
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/904	95/9376	0.436702375407545	CXCL12/ATP6V0A4/ATP6V1B1/MMP3	-1.80251636363921
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	10/904	183/9376	0.566758547318536	RAN/FBL/DKC1/GNL3/NOP56/NOP58/POP7/GAR1/WDR3/RBM28	-1.9333202420491
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/904	98/9376	0.423333935344049	CALM3/PLCD4/INPP4B/PPIP5K2	-1.87450726811079
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/904	45/9376	0.230481809242871	HLA-G	-1.690199359148
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/904	100/9376	0.414867256637168	GYPA/ITGA1/IL1R2/CD7	-1.92154655658526
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/904	104/9376	0.398910823689585	PLA2G2A/PHOSPHO1/PLA2G10/LPCAT1	-2.01347270146692
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/904	195/9376	0.53188109825278	ACTB/HMGB1/ACTG1/SLC25A6/VDAC1/RAC1/VDAC2/SLC25A5/AKT1/MAP2K2	-2.15777108627565
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/904	105/9376	0.395111672987779	CALM3/CBLB/AKT1/PPP3CA	-2.03602657632979
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/904	50/9376	0.207433628318584	CXCL12	-1.8354806815893
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/904	90/9376	0.345722713864307	AKT1/PPP3CA/MAP2K2	-2.03725615488298
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/904	169/9376	0.49096716761795	HMGB1/RPS27A/UBA52/BNIP3/MAP1LC3A/AKT1/NRBF2/MAP2K2	-2.1812575907838
NA	NA	hsa04082	Neuroactive ligand signaling	10/904	199/9376	0.521190020900965	GNAS/SLC1A2/GNAI1/ADCY5/ADRA2C/GNAI3/SLC6A11/GNB5/GNB2/GNG7	-2.23005844646655
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/904	187/9376	0.499171832852208	HSP90AB1/TXN2/VDAC1/TRIP6/YWHAE/VDAC2/CARD16/MAP1LC3A/IFNAR2	-2.2597078978195
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/904	55/9376	0.188576025744167	DEGS2	-1.97140024335583
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/904	78/9376	0.26594054912639	ITGB1/MARCKSL1	-2.12647677997114
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/904	119/9376	0.348627946753923	MMP14/AKT1/TNFRSF1B/MMP3	-2.33584677129842
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/904	62/9376	0.16728518412789	HEY1	-2.14882426569643
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/904	86/9376	0.241201893393702	GNAS/ADCY5	-2.30910928213787
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/904	181/9376	0.40111475089229	CALM3/HSPD1/LBP/AKT1/PPP3CA/NFYB/ATP6V0A4	-2.65756513044676
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/904	72/9376	0.144051130776794	DDX3X	-2.38153023639338
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/904	298/9376	0.487260200748352	LEP/CCR7/CXCL14/BMP4/CXCL12/IL1R2/TNFRSF1B/GDF11/IFNAR2/BMP7/CCL21/ACVRL1/TNFRSF21/CNTFR	-2.93823786877286
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/904	109/9376	0.190306081026224	HSP90AB1/PPP3CA	-2.77741914599857
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/904	93/9376	0.11152345608526	PPP3CA	-2.81267883832722
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/904	250/9376	0.373380530973451	CTSV/SLC29A1/LAPTM4B/CTSE/SLC38A9/SLC29A2/OSBPL6/ATP6V0A4/ATP6V1B1	-3.28027713142986
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/904	370/9376	0.364410428127242	LEP/TMEM97/CGA/GAL/PTH1R/NPW/KISS1R/ADRA2C/LHB/RLN2/GZMA/CHRNA5/LPAR3	-4.0746333336164
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/904	449/9376	0.0461990263515777	CALM3/GNG7	-6.76558016641318