category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	155/2252	222/9376	2.90688557118397	RPL22/RPSA/RPL35A/RPL5/RPL35/RPL36/RPS5/RPL7/RPL10A/RPL23A/RPL24/RPLP0/RPL14/RPL29/RPL3/RPL6/RPL37A/RPS7/RPS9/RPS13/RPL37/RPL7A/RPL18/RPS3/RPL9/RPL26/RPS16/RPL27A/RPS15/RPL18A/RPL15/RPS3A/RPS6/RPL19/RPL21/RPS4X/RPS23/RPL8/RPLP2/RPL32/RPL11/RPS19/RPS27A/RPS8/RPS24/RPL13A/RPS2/RPS14/RPS18/RPL28/RPS12/RPL13/RPLP1/RPL30/RPS25/RPL12/RPL10/RPS11/RPL4/RPS15A/RPL31/RPL34/RPL23/RPL39/RPS20/RPS27/RPL41/RPS10/RPS26/MRPS15/RPL27/MRPS26/MRPL11/RPS29/RPS28/MRPL51/MRPS35/MRPS2/MRPL37/MRPS9/MRPL14/RPL38/MRPL27/UBA52/MRPL4/MRPL12/RPS21/RPL36A/MRPL22/MRPL23/MRPS6/RPL17/MRPL19/MRPL15/MRPL17/MRPL3/MRPS33/MRPS7/MRPL21/MRPS31/MRPL20/MRPS12/MRPL42/MRPL9/MRPL16/MRPS16/MRPS34/MRPS14/MRPL49/MRPL2/MRPL18/MRPS21/MRPL13/RPL26L1/MRPS25/MRPL36/MRPS28/MRPL32/MRPL48/MRPL39/MRPL55/MRPS18C/MRPL35/MRPS5/MRPL50/MRPS22/MRPL46/MRPL40/MRPL47/MRPS18B/MRPL1/RSL24D1/MRPS27/MRPS18A/FAU/MRPS11/MRPL24/MRPL52/MRPL43/MRPL28/MRPL45/MRPS23/MRPS10/MRPL44/MRPL41/MRPL10/RPL22L1/MRPS30/RPL36AL/DAP3/MRPL54/MRPL33/MRPL34/RPS4Y1/RPS17	16.166036002643
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	104/2252	158/9376	2.7404726038177	CCNE1/CCNB1/PCNA/CDK1/PTTG1/CCNB2/MAD2L1/CDC20/CCNA2/AURKB/MCM4/ORC6/CDC6/MCM7/CDT1/CDCA5/NDC80/CDKN1C/TTK/SFN/MCM3/MCM5/FBXO5/CHEK1/SKP2/CDC45/BUB3/TFDP1/PLK1/WEE1/CDK2/DBF4/CDK7/TFDP2/PKMYT1/MCM2/SMC3/MCM6/YWHAQ/RAD21/ESCO2/ANAPC11/BUB1/TRIP13/HDAC1/BUB1B/CCNE2/CDC25A/PRKDC/CDK4/CCND3/YWHAE/CUL1/CDC25C/CHEK2/E2F1/RBX1/ANAPC15/PPP2R1A/ANAPC5/CDC23/SKP1/ORC3/CDKN1B/TICRR/SMC1A/CDC27/DDX11/E2F4/HDAC2/ORC2/ORC1/ORC4/PPP2CA/E2F2/STAG1/CDC7/CDC14B/ANAPC13/E2F5/GADD45A/MTBP/ESPL1/RBL1/STAG2/PDS5B/PPP2R1B/ANAPC10/CDC16/ANAPC1/TP53/YWHAB/E2F3/CDKN2A/ORC5/ANAPC4/MAD2L1BP/MYC/FZR1/SMC1B/CDC25B/CDKN2D/CDKN2C/YWHAZ	12.4046712508923
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	74/2252	108/9376	2.85270705874614	RAN/KPNA2/EEF1A1/RBM8A/ALYREF/NUP37/CSE1L/MAGOHB/MAGOH/IPO5/THOC6/PNN/THOC7/THOC3/NUP54/RNPS1/RANGAP1/SAP18/SUMO2/NUP35/NUP107/SRRM1/UPF3B/RAE1/NUP160/EIF4A3/XPO1/ACIN1/AAAS/PHAX/KPNB1/NXT1/NUP155/SEC13/TPR/NCBP2/NUP50/SNUPN/SEH1L/NUP88/XPOT/IPO7/UBE2I/THOC1/SUMO1/NUP205/NUP62/UPF3A/NUP85/RANBP17/NUP43/NCBP1/IPO9/DDX19A/NMD3/UPF1/IPO4/UPF2/NUP153/CASC3/THOC5/NUP98/NUP93/NUP133/TNPO1/NDC1/SENP2/XPO5/IPO11/TNPO3/XPO7/THOC2/NUP188/TNPO2	10.8876336012907
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	129/2252	268/9376	2.00402958564195	RPS27A/TUBB/TUBA1B/UQCRH/TUBB4B/NDUFA6/PARK7/NDUFA4/PSMC3/TUBA1C/CALM1/PSMB5/PSMD12/GNAI1/UBA52/SLC25A6/TXN2/COX5A/SLC25A4/CYC1/NDUFA12/SOD1/VDAC1/UBE2L3/PSMB7/PSMC5/PSMB2/NDUFV2/NDUFC1/VDAC3/EIF2S1/GNAS/PSMB6/PSMB1/NDUFS5/COX8C/PSMD11/NDUFA11/TRAP1/UQCRFS1/VDAC2/PSMD4/NDUFV1/PSMA4/PSMA7/NDUFS6/PSMD6/COX5B/PSMD14/NDUFB10/UQCR10/PSMA1/PSMD13/PSMA3/NDUFB6/PSMC1/NDUFB4/PSMD2/NDUFA10/PSMC4/PSMB4/NDUFV3/COX7C/ADRM1/NDUFB11/PSMC6/NDUFA8/NDUFS3/NDUFA5/COX6C/PSMD7/TUBB6/NDUFAB1/NDUFS4/NDUFS8/UBE2J2/CAMK2G/PSMD1/PSMD3/PSMD8/SDHC/CALM2/NDUFS2/UBB/PSMA5/NDUFB3/PSMB3/CASP3/SLC39A1/MAPK9/SLC39A4/SLC39A10/HTRA2/NDUFA2/NDUFA9/UQCRQ/NDUFB7/COX7B/NDUFA3/SLC25A5/UBE2G1/COX7A2/NDUFC2/NDUFS7/GNAI3/UQCRC2/TXN/NDUFA13/UQCRC1/ADCY5/PSMC2/TP53/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/DAXX/SLC18A2/UBA1/MFN1/HSPA5/COX8A/CYCS/KLC2/MAPT/GPR37/PLCG1/SLC39A14	9.37584183083487
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	33/2252	36/9376	3.81645944345767	PCNA/FEN1/RFC2/MCM4/MCM7/RNASEH2A/RPA2/RPA3/MCM3/MCM5/PRIM1/RFC4/LIG1/POLD2/SSBP1/POLD3/RFC3/MCM2/MCM6/RFC5/POLE2/RFC1/DNA2/POLA2/RNASEH2C/RPA1/POLE3/RNASEH1/PRIM2/POLA1/POLE4/POLE/POLD1	9.51895316488605
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	157/2252	368/9376	1.77623754730095	HNRNPA1/TUBB/HNRNPA3/TUBA1B/UQCRH/TUBB4B/SRSF3/HNRNPA2B1/GPX3/ALYREF/NUP37/NDUFA6/NDUFA4/PSMC3/TUBA1C/PSMB5/SRSF7/PSMD12/TOMM40/COX5A/CYC1/NDUFA12/SOD1/VDAC1/PSMB7/PSMC5/PSMB2/BAD/NDUFV2/NDUFC1/EIF2S1/PSMB6/PSMB1/NDUFS5/COX8C/PSMD11/GPX8/NDUFA11/NUP54/UQCRFS1/PSMD4/NDUFV1/PSMA4/VCP/HNRNPA1L2/PSMA7/VAPB/NDUFS6/PSMD6/COX5B/PSMD14/NDUFB10/UQCR10/TARDBP/PSMA1/PSMD13/PSMA3/NDUFB6/PSMC1/NDUFB4/PSMD2/NDUFA10/PSMC4/PSMB4/NDUFV3/COX7C/FUS/ADRM1/NUP35/NUP107/NDUFB11/PSMC6/RAE1/NDUFA8/NDUFS3/NUP160/NDUFA5/COX6C/SIGMAR1/PSMD7/TUBB6/NDUFAB1/NDUFS4/NDUFS8/PSMD1/PSMD3/PSMD8/NXT1/SDHC/NUP155/SEC13/TPR/NDUFS2/MATR3/RAB8A/PSMA5/NUP50/NDUFB3/PSMB3/DCTN3/CASP3/SEH1L/NUP88/DCTN2/NDUFA2/NDUFA9/UQCRQ/NUP205/NDUFB7/NUP62/COX7B/NUP85/MAP2K6/NDUFA3/NUP43/NCBP1/DCTN5/COX7A2/NOS2/NDUFC2/DNALI1/NDUFS7/PFN1/UQCRC2/ANXA7/TRAF2/MAPK13/NDUFA13/UQCRC1/WIPI2/PSMC2/TP53/NUP153/CHMP2B/SDHA/NDUFB1/NDUFB2/NUP98/COX7A2L/NDUFS1/CCS/NUP93/NUP133/DAXX/DNAH14/NDC1/ACTG1/HSPA5/COX8A/NRG4/NUP188/CYCS/MAPK14/KLC2/GRIN2D/OPTN/ATG14	8.54106924035299
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	134/2252	308/9376	1.81135383266822	TUBB/TUBA1B/POLR2H/UQCRH/TUBB4B/TFAM/GPX3/NDUFA6/NDUFA4/PSMC3/TUBA1C/PSMB5/PSMD12/POLR2I/SLC25A6/COX5A/SLC25A4/POLR2L/HDAC1/POLR2F/CYC1/NDUFA12/SOD1/VDAC1/PSMB7/PSMC5/TGM2/PSMB2/NDUFV2/NDUFC1/VDAC3/PSMB6/PSMB1/NDUFS5/COX8C/PSMD11/GPX8/NDUFA11/POLR2D/UQCRFS1/VDAC2/PSMD4/NDUFV1/PSMA4/POLR2E/PSMA7/NDUFS6/PSMD6/COX5B/PSMD14/NDUFB10/UQCR10/PSMA1/PSMD13/PSMA3/NDUFB6/PSMC1/NDUFB4/POLR2J/PSMD2/PPARG/NDUFA10/PSMC4/PSMB4/NDUFV3/COX7C/ADRM1/NDUFB11/PSMC6/NDUFA8/NDUFS3/NDUFA5/COX6C/POLR2G/PSMD7/TUBB6/HDAC2/NDUFAB1/NDUFS4/NDUFS8/PSMD1/PSMD3/PSMD8/SDHC/POLR2C/POLR2K/NDUFS2/PSMA5/NDUFB3/PSMB3/TBPL1/DCTN3/CASP3/MAPK9/DCTN2/CLTA/NDUFA2/NDUFA9/UQCRQ/NDUFB7/COX7B/TAF4B/NDUFA3/SLC25A5/RCOR1/DCTN5/COX7A2/NDUFC2/DNALI1/NDUFS7/AP2A1/IFT57/UQCRC2/TRAF2/NDUFA13/UQCRC1/WIPI2/PSMC2/TP53/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/REST/AP2M1/DNAH14/CREB3L4/COX8A/TBP/CYCS/KLC2/PLCB3/ATG14	8.14025051488907
Genetic Information Processing	Transcription	hsa03040	Spliceosome	111/2252	243/9376	1.90180470583076	HNRNPA1/SNRPD1/SNRPD2/SNRPG/HNRNPA3/SNRPF/SNRPE/SNRPB/LSM7/LSM4/SRSF3/LSM3/RBM8A/ALYREF/SNRPA1/HNRNPC/SNRPD3/MAGOHB/LSM2/HNRNPM/U2AF1/SRSF2/SNRPA/MAGOH/SRSF7/SNRNP40/PPIL1/LSM5/RBMX/PRPF19/SF3A3/SNRPC/SNRNP70/SRSF9/THOC6/RBM17/SRSF4/U2SURP/PPIH/TXNL4A/THOC7/THOC3/PUF60/PRPF38A/DDX46/TCERG1/PRPF4/HNRNPA1L2/SRSF1/SF3B2/PRPF31/HNRNPU/LSM6/DHX15/PHF5A/CWC15/SNRPB2/CDC5L/FUS/HNRNPK/WBP11/SNW1/USP39/SF3B4/SRSF10/EIF4A3/SF3B3/ACIN1/ZMAT2/TRA2B/SF3A2/U2AF2/RBM22/DDX42/NCBP2/RP9/DDX23/PRPF40A/SNRNP200/BUD31/PLRG1/RBMX2/THOC1/HSPA8/RBMXL1/CCDC12/PPIE/RBM25/PRPF6/SMNDC1/PRPF3/NCBP1/DHX16/SRSF6/BCAS2/CASC3/THOC5/PRPF8/SNRNP27/AQR/SYF2/BUD13/ISY1/XAB2/SF3B5/SF3A1/EFTUD2/CRNKL1/THOC2/SART1/PRPF40B	8.00786570225245
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	43/2252	63/9376	2.841692745778	PCNA/RFC2/RPA2/POLR2H/RPA3/RFC4/LIG1/POLD2/POLD3/RFC3/CDK7/POLR2I/POLR2L/POLR2F/RFC5/RAD23B/POLE2/RFC1/MNAT1/POLR2D/POLR2E/RPA1/POLE3/DDB1/POLR2J/GTF2H5/RBX1/POLR2G/POLE4/POLR2C/POLR2K/GTF2H3/POLE/GTF2H2/RAD23A/POLD1/XPC/CETN2/ERCC8/GTF2H2C/ERCC2/XPA/GTF2H1	8.24613663515392
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	33/2252	46/9376	2.98679434705383	PSMC3/PSMB5/PSMD12/PSMB7/PSMC5/PSMB2/PSMB6/PSMB1/PSMD11/PSMD4/PSMA4/PSMA7/PSMD6/PSMD14/PSMA1/PSMD13/PSMA3/PSMC1/PSMD2/PSMC4/PSMB4/ADRM1/PSMC6/PSMD7/PSMD1/PSMD3/PSMD8/PSMA5/PSMB3/PSME3/POMP/PSMC2/PSME1	7.59449473752594
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	114/2252	275/9376	1.72592281608267	TUBB/TUBA1B/CAV1/UQCRH/TUBB4B/NDUFA6/NDUFA4/PSMC3/TUBA1C/PSMB5/PSMD12/SLC25A6/COX5A/SLC25A4/CYC1/NDUFA12/SOD1/VDAC1/PSMB7/PSMC5/PSMB2/BAD/NDUFV2/NDUFC1/VDAC3/STIP1/EIF2S1/PSMB6/PSMB1/NDUFS5/COX8C/PSMD11/NDUFA11/UQCRFS1/VDAC2/PSMD4/NDUFV1/PSMA4/PSMA7/NDUFS6/PSMD6/COX5B/PSMD14/NDUFB10/UQCR10/PSMA1/PSMD13/PSMA3/NDUFB6/PSMC1/NDUFB4/PSMD2/NDUFA10/PSMC4/PSMB4/NDUFV3/COX7C/ADRM1/CAV2/NDUFB11/PSMC6/NDUFA8/NDUFS3/NDUFA5/COX6C/PSMD7/TUBB6/NDUFAB1/NDUFS4/NDUFS8/PSMD1/PSMD3/PSMD8/SDHC/PIK3CB/NDUFS2/PSMA5/CSNK2A1/NDUFB3/PSMB3/CASP3/MAPK9/MAPK3/NDUFA2/NDUFA9/UQCRQ/HSPA8/NDUFB7/COX7B/NDUFA3/SLC25A5/COX7A2/CSNK2B/LAMC1/NDUFC2/NDUFS7/CSNK2A2/UQCRC2/MAPK13/NDUFA13/UQCRC1/PSMC2/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/CREB3L4/HSPA5/COX8A/CYCS/MAPK14/KLC2/GRIN2D	6.86942066640436
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	31/2252	44/9376	2.93331180364928	PCNA/FEN1/HMGB1/RFC2/UNG/PARP1/RFC4/LIG1/POLD2/POLD3/RFC3/RFC5/POLE2/RFC1/APEX1/PARP2/POLE3/SMUG1/LIG3/NTHL1/TDG/POLE4/NEIL3/POLE/MUTYH/TDP1/POLD1/POLG2/XRCC1/APTX/NEIL2	7.22684519000056
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	20/2252	23/9376	3.62035678430767	PCNA/RFC2/MSH2/RPA2/RPA3/RFC4/LIG1/POLD2/SSBP1/POLD3/RFC3/RFC5/EXO1/MSH6/RFC1/RPA1/POLD1/MLH1/MSH3/PMS2	7.07386479965608
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	54/2252	103/9376	2.18275879908258	RBM8A/ALYREF/MAGOHB/MAGOH/PAPOLA/MSI2/PNN/PPP1CC/DAZAP1/CPSF6/NUDT21/RNPS1/SAP18/TARDBP/CPSF4/CPSF3/PPP2R1A/FUS/HBS1L/SRRM1/PPP1CA/GSPT1/UPF3B/EIF4A3/CSTF3/ACIN1/WDR33/NXT1/FIP1L1/PPP2CA/NCBP2/PPP2R2A/CSTF2/SSU72/PPP2R3B/UPF3A/NCBP1/SMG6/PPP2R3A/ETF1/DDX19A/PPP2R1B/CSTF1/PABPN1/UPF1/UPF2/CASC3/PABPC4/PPP1CB/CLP1/PELO/RNGTT/CPSF1/CSTF2T	6.7859795416675
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	58/2252	116/9376	2.08170515097691	GCSH/ACAT2/PHGDH/GAPDH/RPIA/PGP/ENO1/TPI1/SHMT1/PSAT1/ADH5/GLDC/IDH2/PDHA1/FH/MDH2/PGAM1/PDHB/IDH1/SUCLG1/ECHS1/GPT2/IDH3A/PCCB/DLAT/ESD/SHMT2/GOT2/SDHC/PFKP/ALDOA/IDH3B/MDH1/PKM/GOT1/SUCLA2/ACO1/GPI/DLD/PFKL/DLST/TALDO1/AMT/TKT/PCCA/RPE/SDHA/HK1/SUCLG2/IDH3G/PSPH/HIBCH/MCEE/PC/ALDH6A1/ALDOC/GLUD2/ACSS1	6.59083250555287
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	145/2252	388/9376	1.5559136437714	GAPDH/TUBB/TUBA1B/UQCRH/TUBB4B/NDUFA6/NDUFA4/PSMC3/NAE1/TUBA1C/CALM1/PSMB5/PSMD12/SLC25A6/COX5A/SLC25A4/CYC1/NDUFA12/VDAC1/PSMB7/PSMC5/PSMB2/BAD/NDUFV2/HRAS/NDUFC1/VDAC3/HSD17B10/EIF2S1/PSMB6/WNT7A/PSMB1/NDUFS5/COX8C/PSMD11/NDUFA11/UQCRFS1/VDAC2/PSMD4/NDUFV1/PSMA4/AXIN2/PSMA7/NDUFS6/PSMD6/COX5B/PSMD14/NDUFB10/UQCR10/PSMA1/PSMD13/PSMA3/NDUFB6/PSMC1/NDUFB4/PSMD2/NDUFA10/PSMC4/PSMB4/NDUFV3/COX7C/ADRM1/NDUFB11/PSMC6/NDUFA8/NDUFS3/PPID/NDUFA5/COX6C/AKT1/FZD3/PSMD7/TUBB6/BACE2/MAP2K2/NDUFAB1/NDUFS4/NDUFS8/PSMD1/PSMD3/PSMD8/SDHC/CALM2/PIK3CB/NDUFS2/PSMA5/CSNK2A1/NDUFB3/PSMB3/CASP3/CAPN1/SLC39A1/MAPK9/SLC39A4/SLC39A10/MAPK3/CSNK1E/NDUFA2/NDUFA9/UQCRQ/NDUFB7/WNT10B/DVL1/MME/COX7B/DVL3/NDUFA3/SLC25A5/FADD/COX7A2/CSNK2B/NOS2/NDUFC2/NDUFS7/CSNK2A2/UQCRC2/TRAF2/APP/NDUFA13/UQCRC1/WIPI2/PSMC2/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/FRAT2/LRP5/LRP6/COX8A/DVL2/IDE/CYCS/AKT3/KLC2/MAPT/PLCB3/FZD6/GRIN2D/AXIN1/WNT4/DKK1/SLC39A14/ATG14	6.28781187921011
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	97/2252	235/9376	1.71851403952987	RPS6/UQCRH/NDUFA6/NDUFA4/KDM1A/COA4/COX5A/CYC1/NDUFA12/ACTL6A/SMARCC1/COX20/NDUFV2/HRAS/NDUFC1/GNAS/SMARCB1/NDUFS5/COX8C/NDUFA11/UQCRFS1/NDUFAF4/NDUFV1/NDUFS6/COX5B/NDUFB10/UQCR10/NDUFB6/NDUFB4/COA3/PPARG/SMARCA2/NDUFA10/NDUFV3/COX7C/COA6/NDUFB11/SMARCE1/RPS6KB2/NDUFA8/NDUFS3/NDUFA5/COX6C/NDUFAF2/NDUFAF6/SMARCD1/NDUFAB1/NDUFS4/NDUFS8/SDHC/NDUFS2/NDUFB3/COX10/SMARCD2/SMARCA4/COA1/NDUFA2/NDUFA9/UQCRQ/NDUFB7/CPT1C/COA7/COX7B/COX11/MLST8/NDUFA3/COX7A2/COX16/NDUFC2/NDUFS7/UQCRC2/NDUFAF7/MAPK13/NDUFA13/COX19/UQCRC1/ADCY5/SDHA/AKT1S1/NDUFB1/NDUFB2/COX7A2L/NDUFS1/DPF3/NDUFAF1/PRKAB1/ACTG1/RPS6KB1/CREB3L4/ADCY6/COX15/COX8A/COA5/NDUFAF5/MAPK14/CPT2/COX18	6.27162685496633
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	171/2252	480/9376	1.48321492007105	RPS27A/TUBB/TUBA1B/UQCRH/TUBB4B/GPX3/NDUFA6/PARK7/NDUFA4/PSMC3/TUBA1C/CALM1/PSMB5/PSMD12/TOMM40/UBA52/SLC25A6/COX5A/SLC25A4/CYC1/NDUFA12/SOD1/VDAC1/UBE2L3/PSMB7/PSMC5/PSMB2/BAD/NDUFV2/HRAS/NDUFC1/VDAC3/HSD17B10/EIF2S1/PSMB6/WNT7A/PSMB1/NDUFS5/COX8C/PSMD11/GPX8/NDUFA11/TRAP1/UQCRFS1/VDAC2/PSMD4/NDUFV1/PSMA4/AXIN2/VCP/PSMA7/VAPB/NDUFS6/PSMD6/COX5B/PSMD14/NDUFB10/UQCR10/TARDBP/PSMA1/PSMD13/PSMA3/NDUFB6/PSMC1/NDUFB4/PSMD2/NDUFA10/PSMC4/PSMB4/NDUFV3/COX7C/FUS/ADRM1/NDUFB11/PSMC6/NDUFA8/NDUFS3/PPID/NDUFA5/COX6C/SIGMAR1/FZD3/PSMD7/TUBB6/MAP2K2/NDUFAB1/NDUFS4/NDUFS8/UBE2J2/CAMK2G/PSMD1/PSMD3/PSMD8/SDHC/CALM2/NDUFS2/UBB/RAB8A/PSMA5/CSNK2A1/NDUFB3/PSMB3/DCTN3/CASP3/CAPN1/MAPK9/MAPK3/DCTN2/HTRA2/CSNK1E/NDUFA2/NDUFA9/UQCRQ/NDUFB7/WNT10B/DVL1/COX7B/DVL3/MAP2K6/NDUFA3/SLC25A5/FADD/DCTN5/UBE2G1/COX7A2/CSNK2B/NOS2/NDUFC2/DNALI1/NDUFS7/CSNK2A2/IFT57/UQCRC2/TRAF2/APP/MAPK13/NDUFA13/UQCRC1/WIPI2/PSMC2/CHMP2B/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/CCS/FRAT2/DAXX/DNAH14/LRP5/UBA1/MFN1/LRP6/HSPA5/COX8A/DVL2/CYCS/MAPK14/KLC2/MAPT/PLCB3/GPR37/FZD6/PLCG1/GRIN2D/AXIN1/WNT4/DKK1/OPTN/ATG14	6.1104253512054
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	70/2252	154/9376	1.89245922816083	DHFR/UMPS/NME1/SHMT1/AK2/PSAT1/MTHFD1L/UGP2/HMBS/CTPS1/ALAS2/GGH/MMAB/QPRT/MTHFD1/PMM1/ADSL/COQ3/AK5/AK1/NME2/NME6/RFK/BCAT2/SHMT2/CPOX/PTS/FLAD1/COQ4/RDH13/GSS/COX10/UROS/PMM2/GCLM/DLD/COQ5/LIAS/DHODH/LIPT2/CAD/PHOSPHO2/TPK1/UROD/PPCDC/NFS1/ALAD/UGDH/PANK2/ALDH1B1/PPCS/CMPK1/COASY/VKORC1L1/COQ7/NME1-NME2/PANK1/MOCS2/NADK2/EARS2/COX15/OXSM/FECH/PPOX/HSD17B6/MOCS1/AK3/MPI/COQ6/AK4	6.27832888254352
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	24/2252	34/9376	2.9388778602027	POLR2H/POLR2I/POLR2L/POLR2F/POLR3K/POLR1E/POLR2D/POLR2E/POLR2J/POLR1D/POLR2G/POLR2C/POLR2K/POLR3G/POLR3H/POLR3B/POLR1C/POLR3D/POLR3A/POLR3F/POLR1A/POLR3E/POLR1B/POLR3C	6.36763050260244
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	56/2252	117/9376	1.99274339238815	RBBP7/RUVBL1/ACTR6/MTA3/HDAC1/RUVBL2/ACTL6A/SMARCC1/CDK2AP2/YEATS4/SMARCB1/UCHL5/POLE3/RBBP4/BRD7/SMARCA2/SMARCA5/MORF4L1/SMARCE1/YY1/INO80C/HDAC2/SMARCD1/BAZ1B/CHRAC1/MORF4L2/MRGBP/CDK2AP1/BRD8/SMARCD2/SMARCA4/MBD3/GATAD2A/MCRS1/ING3/BCL7C/DMAP1/SS18/VPS72/CECR2/CHD3/NFRKB/BRD9/INO80E/MTA2/DPF3/PHF6/ZNHIT1/KAT5/ACTG1/PHF10/BCL7B/MTA1/BCL7A/ACTR5/ACTR8	6.07513271549112
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	27/2252	41/9376	2.74175800372569	RAD51/RPA2/RPA3/RAD51C/POLD2/SSBP1/POLD3/BLM/XRCC2/BRCA1/BARD1/RPA1/TOPBP1/BRCC3/RAD54L/BABAM1/RAD54B/BRIP1/BRCA2/EME1/POLD1/XRCC3/RAD51D/RBBP8/RAD50/MUS81/RAD52	6.28391725882414
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	64/2252	142/9376	1.8764666149651	UBE2C/CDC20/RPS27A/UBE2S/SKP2/SAE1/UBA52/ANAPC11/PRPF19/UBA2/UBE2L3/UBE2N/CUL1/BRCA1/UBE2M/DDB1/RBX1/UBE2D2/ANAPC15/ANAPC5/CDC23/SKP1/FANCL/CDC27/UBE2K/UBE2J2/UBE2E3/NEDD4/FBXO4/UBB/TRIM37/UBE2I/ANAPC13/CUL3/UBE2H/FBXW7/UBE2Q2/UBE2G1/UBE2F/CDC34/HUWE1/MID1/ANAPC10/CDC16/ANAPC1/CBLC/SIAH1/CUL2/BTRC/UBE2O/HERC3/HERC4/ANAPC4/UBA1/UBA3/VHL/FZR1/RHOBTB2/RCHY1/ERCC8/HERC2/SMURF1/UBE4B/RHOBTB1	5.91687631848162
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	32/2252	54/9376	2.46720610486152	UBE2T/RAD51/RPA2/RPA3/USP1/RAD51C/FANCI/BLM/BRCA1/FANCE/RPA1/FANCD2/FANCG/FANCB/RMI2/FANCL/RMI1/BRIP1/BRCA2/EME1/FANCA/MLH1/TELO2/ATRIP/FANCM/MUS81/WDR48/FANCF/PMS2/POLI/FANCC/SLX4	6.07912861657189
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	94/2252	238/9376	1.64437213606579	RPL22/RPSA/RPL35A/RPL5/RPL35/RPL36/RPS5/RPL7/RPL10A/RPL23A/RPL24/RPLP0/RPL14/RPL29/RPL3/RPL6/RPL37A/RPS7/RPS9/RPS13/RPL37/RPL7A/RPL18/RPS3/RPL9/RPL26/RPS16/RPL27A/RPS15/RPL18A/RPL15/RPS3A/RPS6/RPL19/RPL21/RPS4X/RPS23/RPL8/RPLP2/RPL32/RPL11/RPS19/RPS27A/RPS8/RPS24/RPL13A/RPS2/RPS14/RPS18/RPL28/RPS12/RPL13/RPLP1/RPL30/RPS25/RPL12/RPL10/RPS11/RPL4/RPS15A/RPL31/RPL34/RPL23/RPL39/RPS20/RPS27/RPL41/RPS10/RPS26/RPL27/RPS29/RPS28/RPL38/UBA52/RPS21/RPL36A/RPL17/RPL26L1/RSL24D1/FAU/RPL22L1/IRF3/PIK3CB/RPL36AL/MAPK9/MAPK3/C1R/MAPK13/RPS4Y1/RPS17/MAPK14/PLCG1/MAVS/C1S	5.6611873812295
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	21/2252	30/9376	2.91438721136767	IDH2/PDHA1/FH/MDH2/PDHB/IDH1/SUCLG1/IDH3A/DLAT/SDHC/IDH3B/MDH1/SUCLA2/ACO1/ACLY/DLD/DLST/SDHA/SUCLG2/IDH3G/PC	5.90453089446612
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	61/2252	138/9376	1.84034803202306	PPA1/UQCRH/NDUFA6/NDUFA4/COX5A/CYC1/NDUFA12/ATP6V1C2/NDUFV2/NDUFC1/NDUFS5/COX8C/NDUFA11/UQCRFS1/PPA2/NDUFV1/NDUFS6/COX5B/NDUFB10/UQCR10/NDUFB6/NDUFB4/NDUFA10/NDUFV3/COX7C/NDUFB11/NDUFA8/NDUFS3/NDUFA5/COX6C/NDUFAB1/NDUFS4/NDUFS8/ATP6V1B1/SDHC/NDUFS2/NDUFB3/COX10/NDUFA2/NDUFA9/UQCRQ/NDUFB7/COX7B/COX11/NDUFA3/COX7A2/NDUFC2/NDUFS7/UQCRC2/NDUFA13/UQCRC1/SDHA/ATP6V1E1/NDUFB1/NDUFB2/COX7A2L/NDUFS1/LHPP/COX15/COX8A/CYCS	5.59136221777365
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	27/2252	44/9376	2.55481995801712	CDK7/TAF15/TAF9/MNAT1/GTF2H5/TAF11/GTF2H3/TAF9B/GTF2A2/TBPL1/GTF2H2/TAF5/TAF4B/GTF2B/GTF2F2/TAF12/GTF2F1/TAF5L/GTF2E2/TAF6/TBP/GTF2H2C/TAF6L/ERCC2/TAF8/GTF2H1/TAF2	5.81201806853048
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	66/2252	157/9376	1.75022343903791	UQCRH/NDUFA6/NDUFA4/COX5A/LEP/CYC1/NDUFA12/NDUFV2/NDUFC1/EIF2S1/NDUFS5/COX8C/NDUFA11/UQCRFS1/NDUFV1/NDUFS6/COX5B/NDUFB10/UQCR10/NDUFB6/NDUFB4/PPARG/NDUFA10/NDUFV3/COX7C/NDUFB11/NDUFA8/NDUFS3/NDUFA5/COX6C/AKT1/NDUFAB1/NDUFS4/NDUFS8/SDHC/PIK3CB/NDUFS2/NDUFB3/CASP3/MAPK9/NDUFA2/NDUFA9/UQCRQ/NDUFB7/COX7B/NDUFA3/COX7A2/NDUFC2/NDUFS7/UQCRC2/TRAF2/MAPK13/NDUFA13/UQCRC1/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/PRKAB1/COX8A/CYCS/GSK3A/MAPK14/AKT3/CDC42	5.32974490611054
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	81/2252	205/9376	1.64505480223541	GAPDH/UQCRH/PARP1/NDUFA6/NDUFA4/SLC25A6/COX5A/SLC25A4/CYC1/NDUFA12/VDAC1/PDHA1/SLC2A1/NDUFV2/NDUFC1/VDAC3/NDUFS5/COX8C/NDUFA11/PPP1CC/PDHB/UQCRFS1/VDAC2/NDUFV1/NDUFS6/COX5B/NDUFB10/UQCR10/NDUFB6/NDUFB4/NDUFA10/NDUFV3/COX7C/PPP1CA/NDUFB11/NDUFA8/NDUFS3/NDUFA5/COX6C/AKT1/NDUFAB1/NDUFS4/NDUFS8/CAMK2G/PRKCZ/SDHC/PIK3CB/NDUFS2/MPC2/NDUFB3/MAPK9/GYS1/NDUFA2/NDUFA9/UQCRQ/PDK3/NDUFB7/COX7B/NDUFA3/SLC25A5/COX7A2/MMP2/NDUFC2/NDUFS7/UQCRC2/MAPK13/NDUFA13/UQCRC1/SDHA/NDUFB1/GFPT1/NDUFB2/COX7A2L/NDUFS1/PPP1CB/COX8A/MAPK14/AKT3/TBC1D4/PLCB3/CPT2	5.25016645095345
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	39/2252	78/9376	2.08170515097691	HSPD1/LSM7/EXOSC8/LSM4/LSM3/ENO1/LSM2/EXOSC9/LSM5/DCPS/EXOSC3/EXOSC5/EXOSC2/EXOSC7/LSM6/DHX36/BTG3/DCP2/HSPA9/PFKP/EXOSC6/MPHOSPH6/EXOSC4/EXOSC10/PNPT1/PFKL/CNOT3/CNOT10/PARN/CNOT7/XRN2/EXOSC1/DCP1A/CNOT6/PABPC4/DIS3/NUDT16/EDC3/DIS3L	5.39348287458982
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	40/2252	85/9376	1.9592519068018	TYMS/RRM2/DUT/RRM1/TK1/IMPDH2/DTYMK/GMPS/NME1/ADK/AK2/DCTPP1/CTPS1/NT5C3B/PNP/ADSL/NT5C/NTPCR/AK5/HDDC2/AK1/NME2/NME6/UCK1/APRT/UCK2/GMPR2/DGUOK/ITPA/NT5M/CMPK1/NME1-NME2/NUDT16/DCK/ASMTL/UCKL1/ENTPD5/ADA/AK3/AK4	4.9948077841909
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	16/2252	23/9376	2.89628542744613	ACAT2/FDPS/PMVK/ICMT/IDI1/HMGCS1/HMGCR/FNTA/MVK/PDSS1/RCE1/PDSS2/MVD/FNTB/DHDDS/GGPS1	5.11917568464104
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	28/2252	54/9376	2.15880534175383	PHGDH/LDHB/ADI1/LDHA/SRM/DNMT1/PSAT1/CISD1/MTAP/AHCY/MDH2/CBS/DNMT3B/ENOPH1/BCAT2/MPST/GOT2/AMD1/MDH1/GSS/AHCYL1/GOT1/GCLM/CDO1/SMS/TST/AHCYL2/MRI1	4.8013204762101
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	35/2252	75/9376	1.94292480757845	PHGDH/GAPDH/RPIA/ENO1/TPI1/SHMT1/PSAT1/IDH2/PGAM1/CBS/IDH1/GPT2/IDH3A/BCAT2/SHMT2/PYCR2/GOT2/ASS1/PFKP/ARG2/ALDOA/IDH3B/ASNS/PKM/GOT1/ACO1/PFKL/TALDO1/TKT/RPE/ASL/IDH3G/PSPH/PC/ALDOC	4.60946739366596
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	57/2252	144/9376	1.64801657785672	NOP56/PSMC3/PSMB5/PSMD12/SLC25A6/SLC25A4/VDAC1/PSMB7/PSMC5/PSMB2/VDAC3/PSMB6/PSMB1/PSMD11/VDAC2/PSMD4/PSMA4/PSMA7/PSMD6/PSMD14/PSMA1/PSMD13/PSMA3/PSMC1/PSMD2/PSMC4/PSMB4/ADRM1/PSMC6/AKT1/PSMD7/ATXN10/PSMD1/PSMD3/PSMD8/PIK3CB/PSMA5/PSMB3/TBPL1/AFG3L2/MAPK9/SLC25A5/GTF2B/TRAF2/VLDLR/WIPI2/PSMC2/OPA1/KAT5/PUM2/TBP/CYCS/AKT3/PLCB3/GRIN2D/ATG14/RORA	4.40582598861323
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	25/2252	48/9376	2.16844286560095	ACAT2/ALDH7A1/HSD17B10/HADH/MCCC2/ECHS1/BCAT2/PCCB/HIBADH/OXCT1/HMGCS1/DLD/ALDH9A1/PCCA/ALDH1B1/ACAD8/BCKDHB/ACADSB/HIBCH/AACS/IVD/MCEE/AUH/ALDH6A1/EHHADH	4.56290794401418
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	20/2252	37/9376	2.25049205511017	GNPNAT1/UGP2/PGM1/CMAS/PMM1/PGM3/GALT/PMM2/GPI/UAP1/GALE/UGDH/GFPT1/HK1/GNE/UXS1/TGDS/GMDS/GALK2/MPI	4.28488812228162
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	18/2252	33/9376	2.27095107379299	IDH2/DHTKD1/PDHA1/PDHB/IDH1/AADAT/GPT2/IDH3A/BCAT2/DLAT/GOT2/IDH3B/GOT1/ACO1/DLD/DLST/IDH3G/BCKDHB	4.1119753619263
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	52/2252	138/9376	1.56882127319999	CCNE1/CCNB1/CDK1/PTTG1/CCNB2/MAD2L1/CDC20/AURKA/FBXO5/PLK1/CDK2/CALM1/PKMYT1/SMC3/YWHAQ/ANAPC11/BUB1/CCNE2/YWHAE/PPP1CC/CUL1/CDC25C/RBX1/ANAPC15/PPP2R1A/ANAPC5/CDC23/SKP1/PPP1CA/SMC1A/CDC27/CAMK2G/PPP2CA/CALM2/MAPK3/ANAPC13/ESPL1/PPP2R1B/ANAPC10/MAPK13/ADCY5/CDC16/ANAPC1/BTRC/YWHAB/PPP1CB/ANAPC4/ADCY6/SLK/SMC1B/MAPK14/YWHAZ	3.78472448847126
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	78/2252	227/9376	1.43059913459206	UQCRH/GSTA4/NDUFA6/ACP1/NDUFA4/SLC25A6/COX5A/SLC25A4/CYC1/NDUFA12/SOD1/VDAC1/BAD/NDUFV2/HRAS/NDUFC1/VDAC3/NDUFS5/COX8C/NDUFA11/UQCRFS1/VDAC2/NDUFV1/NDUFS6/COX5B/NDUFB10/UQCR10/MGST3/NDUFB6/NDUFB4/NDUFA10/NDUFV3/COX7C/PTK2/NDUFB11/NDUFA8/NDUFS3/NDUFA5/COX6C/AKT1/MAP2K2/NDUFAB1/NDUFS4/NDUFS8/SDHC/PIK3CB/NDUFS2/NDUFB3/PTPN11/MAPK9/GSTO2/MAPK3/NDUFA2/NDUFA9/UQCRQ/NDUFB7/COX7B/NDUFA3/SLC25A5/COX7A2/NDUFC2/NDUFS7/UQCRC2/MAPK13/NDUFA13/UQCRC1/SDHA/NDUFB1/NDUFB2/COX7A2L/NDUFS1/CBR1/ARNT/COX8A/MAPK14/AKT3/GSTM3/MET	3.69238640566141
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	12/2252	19/9376	2.62952229597083	GCSH/GLDC/DHTKD1/PDHA1/PDHB/DLAT/DLD/DLST/LIAS/LIPT2/AMT/BCKDHB	3.99739135331342
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	17/2252	32/9376	2.21181172291297	LDHB/LDHA/SUCLG1/ECHS1/PCCB/SUCLA2/DLD/ACACA/ECHDC1/PCCA/SUCLG2/BCKDHB/HIBCH/MCEE/ALDH6A1/EHHADH/ACSS1	3.86057149477562
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	34/2252	83/9376	1.70549337670397	PXMP2/ECI2/IDH2/SOD1/PMVK/PRDX5/ECH1/IDH1/PXMP4/MPV17L2/SLC25A17/SLC27A2/ABCD3/MVK/PHYH/CRAT/CROT/PEX19/NOS2/HACL1/PEX7/PEX3/FAR1/PEX13/NUDT7/PECR/PEX1/PEX5/PEX11A/FAR2/PEX2/PEX10/EHHADH/PEX14	3.62962614328657
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	26/2252	59/9376	1.83472318391185	TYMS/RRM2/DUT/RRM1/TK1/DTYMK/UMPS/NME1/DCTPP1/CTPS1/NT5C3B/NT5C/HDDC2/NME2/NME6/UCK1/UCK2/DHODH/CAD/NT5M/CMPK1/NME1-NME2/DCK/ASMTL/UCKL1/ENTPD5	3.61608233065393
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	19/2252	39/9376	2.02832809582366	TYMS/GCSH/DHFR/ALDH7A1/ATIC/SHMT1/MTHFD1L/GLDC/AHCY/MTHFD1/CBS/GART/SHMT2/MTHFS/AHCYL1/DLD/AMT/CHDH/AHCYL2	3.61799699405132
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	16/2252	31/9376	2.14885693004068	GCSH/ACAT2/PGP/SHMT1/GLDC/MDH2/PCCB/SHMT2/GRHPR/MDH1/ACO1/DLD/AMT/PCCA/MCEE/ACSS1	3.60217674570953
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	33/2252	83/9376	1.65533180680092	AURKB/EZH2/RBBP7/TFDP1/WDR5/CBX3/SUZ12/HDAC1/EED/RBBP4/PCGF6/UBE2D2/SKP1/YY1/HDAC2/AEBP2/MTF2/RNF2/PCGF2/TEX10/CSNK2B/ASXL1/SCML2/USP16/SFMBT1/L3MBTL2/USP45/FOXK2/L3MBTL3/PHC1/CBX4/PCGF1/CBX2	3.37155462692586
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	21/2252	47/9376	1.86024715619213	ACAT2/LDHB/ALDH7A1/LDHA/GLO1/ADH5/PDHA1/FH/MDH2/PDHB/DLAT/GRHPR/ACYP1/MDH1/PKM/DLD/ALDH9A1/ACACA/ALDH1B1/PC/ACSS1	3.3240113951014
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	54/2252	157/9376	1.43200099557647	CCNE1/CCNB1/CDK1/CCNB2/CCNA2/CHEK1/MYBL2/CDK2/CALM1/SLC25A6/SLC25A4/FOXM1/RRAS2/VDAC1/CCNE2/CDC25A/CDK4/CCND3/HRAS/VDAC3/PPP1CC/VDAC2/CHEK2/RBBP4/E2F1/RAD1/HLA-G/PPP1CA/PPID/AKT1/E2F4/MAP2K2/CALM2/PIK3CB/E2F2/CAPN1/MAPK3/LIN9/E2F5/GADD45A/MAP2K6/SLC25A5/RBL1/MAPK13/TP53/BTRC/E2F3/TRAF3IP2/CDKN2A/PPP1CB/RAD50/MYC/MAPK14/AKT3	3.06902582057562
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	11/2252	20/9376	2.2898756660746	FDFT1/SQLE/EBP/MSMO1/DHCR24/DHCR7/LBR/TM7SF2/NSDHL/HSD17B7/CYP51A1	3.24657632170797
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	53/2252	157/9376	1.40548245862135	BIRC5/TEAD4/ID1/YWHAQ/BMP7/YAP1/CCND3/PARD3/WNT7A/YWHAE/PPP1CC/AXIN2/CDH1/DLG5/TEAD3/PPP2R1A/BMP4/PARD6B/PPP1CA/WWTR1/FZD3/PRKCZ/PPP2CA/RASSF6/FRMD6/PPP2R2A/WTIP/DLG3/CSNK1E/WNT10B/DVL1/TCF7L2/DVL3/STK3/CTNNA1/TEAD1/PPP2R1B/PRKCI/BTRC/YWHAB/PPP1CB/ACTG1/TEAD2/MYC/AMOT/DVL2/TCF7/FZD6/YWHAZ/SAV1/AXIN1/WNT4/AJUBA	2.88063256344771
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	17/2252	38/9376	1.86257829297934	GNPNAT1/UGP2/PGM1/PMM1/PGM3/GALT/PMM2/GPI/UAP1/GALE/UGDH/GFPT1/HK1/GNE/UXS1/GALK2/MPI	2.99551338294333
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	16/2252	37/9376	1.80039364408814	PPAT/ADSL/GPT2/NIT2/GOT2/ASS1/ASNS/RIMKLB/GOT1/ALDH4A1/CAD/GFPT1/ASL/RIMKLA/ALDH5A1/GLUD2	2.74259816740764
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	22/2252	56/9376	1.63562547576757	TUSC3/DPM1/MAN1A2/TMEM258/DPM2/B4GALT3/DHRSX/B4GALT2/FUT8/OSTC/STT3A/DOLPP1/DDOST/MGAT3/ALG6/ALG14/ALG8/MOGS/ALG12/MGAT5B/ALG9/ALG10	2.68222513877267
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	33/2252	93/9376	1.47733913940297	RAC3/ACP1/PARD3/ARHGAP29/CDH1/YES1/CDH5/WASL/MYL12B/ERBB2/CSNK2A1/VCL/MAPK3/CTNND1/TJP1/TCF7L2/CTNNA1/CSNK2B/PDCD10/WASF1/ACTN4/CSNK2A2/MYL9/KRIT1/SSX2IP/LMO7/ACTG1/SNAI1/CDC42/SMURF1/TCF7/MET/CCM2	2.60095130090432
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	24/2252	63/9376	1.58606106741098	ACAT2/EZH2/ALDH7A1/SMYD2/DHTKD1/AADAT/HADH/ECHS1/HYKK/SUV39H2/DLD/ALDH9A1/DLST/EHMT1/GCDH/SMYD3/SETMAR/ALDH1B1/SUV39H1/NSD1/AASS/EHMT2/SETDB1/EHHADH	2.62407486237534
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	17/2252	41/9376	1.72629207641988	GCSH/PHGDH/ALDH7A1/GAMT/SHMT1/PSAT1/GLDC/ALAS2/GCAT/PGAM1/CBS/SHMT2/GRHPR/DLD/AMT/CHDH/PSPH	2.62031769292841
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	13/2252	29/9376	1.86635634225516	TEAD4/YAP1/TEAD3/WWTR1/RASSF6/FRMD6/WTIP/CSNK1E/STK3/TEAD1/TEAD2/SAV1/AJUBA	2.62704379285528
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	54/2252	170/9376	1.32249503709121	GSTP1/GSTA4/ACTL6A/SMARCC1/CDK4/BAD/HRAS/WNT7A/SMARCB1/AXIN2/E2F1/MGST3/BRD7/SMARCA2/SMARCE1/RPS6KB2/AKT1/FZD3/SMARCD1/MAP2K2/PIK3CB/E2F2/SMARCD2/SMARCA4/GSTO2/MAPK3/GADD45A/WNT10B/DVL1/TCF7L2/DVL3/TP53/FRAT2/E2F3/DPF3/CDKN2A/GAB1/LRP5/ACTG1/PHF10/RPS6KB1/LRP6/MYC/DVL2/TXNRD3/AKT3/TXNRD2/GSTM3/TCF7/FZD6/MET/PLCG1/AXIN1/WNT4	2.38572228284306
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/2252	75/9376	1.49882770870337	RRM2/CCNE1/CCNB1/CDK1/CCNB2/SIVA1/GTSE1/SFN/CHEK1/PERP/CDK2/EI24/CCNE2/CDK4/CCND3/CCNG1/CHEK2/SHISA5/CASP3/CCNG2/GADD45A/TP53/SIAH1/PPP1R13L/CDKN2A/RCHY1/CYCS	2.43850839414256
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	8/2252	15/9376	2.22048549437537	ACP1/AK2/NTPCR/AK5/AK1/TPK1/NFS1/AK4	2.65965316050513
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	37/2252	110/9376	1.40041982883901	CCNB1/CDK1/CCNB2/MAD2L1/AURKA/CCNA2/HSP90AB1/PLK1/CDK2/PKMYT1/GNAI1/ANAPC11/BUB1/KIF22/CDC25A/CDC25C/ANAPC15/ANAPC5/CDC23/AKT1/CDC27/PIK3CB/MAPK9/MAPK3/ANAPC13/GNAI3/ANAPC10/MAPK13/ADCY5/CDC16/ANAPC1/ANAPC4/FZR1/ADCY6/CDC25B/MAPK14/AKT3	2.37505486330778
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	57/2252	183/9376	1.29679993011676	RAN/POP7/FBL/NOP56/NHP2/GNL3/NOP58/RRP7A/EMG1/DKC1/GAR1/RPP30/IMP3/NOB1/WDR43/MPHOSPH10/EIF6/TCOF1/RBM28/GTPBP4/IMP4/UTP18/POP5/RPP40/XPO1/RIOK1/SBDS/NXT1/RPP25L/UTP6/UTP14A/NAT10/RPP38/WDR75/CSNK2A1/BMS1/GNL2/RCL1/REXO2/HEATR1/XRN2/CSNK2B/UTP15/REXO1/LSG1/CSNK2A2/NMD3/POP4/MDN1/POP1/WDR3/TBL3/NVL/PWP2/RIOK2/DROSHA/GNL3L	2.27965215832309
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	19/2252	50/9376	1.58209591474245	ALDH7A1/SRM/GAMT/CKMT1A/CKMT1B/OAT/PYCR2/GOT2/AMD1/ARG2/GOT1/ALDH4A1/ALDH9A1/CKB/NOS2/ALDH1B1/L3HYPDH/SMS/P4HA2	2.32027640578976
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	53/2252	170/9376	1.29800438825619	PCNA/TUBA1B/ARPC1A/JAM3/TUBA1C/CLDN7/ARPC5L/CLDN10/CTTN/CLDN6/CDK4/PARD3/CLDN4/MYL6B/EPB41L4B/PPP2R1A/EZR/PARD6B/MARVELD2/MYH10/CLDN3/PRKCZ/MYL12B/HSPA4/PPP2CA/RDX/PPP2R2A/NEDD4/RAB8A/ERBB2/TJP2/MAPK9/MPDZ/DLG3/TJP1/ACTR3B/ACTN4/PPP2R1B/AMOTL1/MYL9/PRKCI/AMOTL2/MARVELD3/CRB3/PRKAB1/ACTG1/TJP3/AMOT/OCLN/CDC42/STK11/CGNL1/TJAP1	2.2045477532317
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	24/2252	67/9376	1.49137085443122	GAPDH/LDHB/ALDH7A1/LDHA/ENO1/TPI1/ADH5/PGM1/PDHA1/PGAM1/PDHB/DLAT/PFKP/ALDOA/PKM/GPI/DLD/ALDH9A1/PFKL/ALDH1B1/HK1/ALDH3B2/ALDOC/ACSS1	2.26935874191368
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	21/2252	57/9376	1.53388800598299	ACAT2/FASN/ELOVL6/HADH/ECHS1/CBR4/MECR/FADS1/TECR/CPT1C/ACACA/PPT2/ELOVL2/MCAT/ELOVL1/ACADSB/OXSM/HSD17B8/FADS2/CPT2/EHHADH	2.27305954282654
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/2252	31/9376	1.74594625565805	UBL4A/SRP9/SRP14/SRP68/SRP72/IMMP1L/SRP54/SRP19/SEC11A/SGTA/SRPRB/HSPA5/IMMP2L	2.338872826911
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	47/2252	149/9376	1.31329049793174	NDUFA6/NDUFA4/GNAI1/NDUFA12/NDUFV2/NDUFC1/GNG12/NDUFS5/NDUFA11/NDUFV1/NDUFS6/NDUFB10/NDUFB6/NDUFB4/NDUFA10/NDUFV3/NDUFB11/NDUFA8/NDUFS3/NDUFA5/GNB5/NDUFAB1/NDUFS4/NDUFS8/NDUFS2/NDUFB3/MAPK9/MAPK3/NDUFA2/NDUFA9/NDUFB7/NDUFA3/GNG4/NDUFC2/NDUFS7/GNAI3/MAPK13/NDUFA13/ADCY5/NDUFB1/NDUFB2/NDUFS1/GNB2/ADCY6/MAPK14/PLCB3/GABRE	2.16729471906655
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	25/2252	71/9376	1.46598954294149	LDHB/LDHA/IDH2/PDHA1/SLC2A1/HRAS/PGAM1/PDHB/IDH1/AKT1/MAP2K2/PFKP/PIK3CB/PKM/ERBB2/MAPK3/PFKL/SLC1A5/TP53/HK1/MYC/AKT3/SIRT3/MET/PDK1	2.21592487398445
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	41/2252	128/9376	1.33359236234458	RRM2/PAICS/RRM1/IMPDH2/GMPS/ATIC/PPAT/NME1/ADK/AK2/NUDT5/PGM1/PNP/GART/ADSL/NT5C/NTPCR/AK5/HDDC2/AK1/NME2/NME6/APRT/PDE4D/GMPR2/DGUOK/HDDC3/ITPA/NT5M/ADCY5/PFAS/NME1-NME2/ADCY6/NUDT16/DCK/PDE6D/PDE4C/ENTPD5/ADA/AK3/AK4	2.13651058603322
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	26/2252	75/9376	1.44331557134399	TOP2A/BIRC5/GSTP1/MSH2/GSTA4/MSH6/BAD/BRCA1/MGST3/AKT1/PIK3CB/ERBB2/TOP2B/CASP3/GSTO2/MAPK3/MLH1/FADD/TP53/ATP7B/MSH3/CDKN2A/CYCS/AKT3/GSTM3/XPA	2.16713851920214
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	14/2252	35/9376	1.66536412078153	AKR1B1/TPI1/PMM1/ENOSF1/PFKP/ALDOA/PMM2/PFKL/PFKFB4/HK1/GMDS/KHK/ALDOC/MPI	2.21719857203361
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	9/2252	20/9376	1.87353463587922	UGP2/CMAS/UAP1/CYB5R2/UGDH/GNE/TGDS/GMDS/CYB5RL	2.19865909531256
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	35/2252	110/9376	1.32472145971258	GAPDH/RPS6/LDHB/LDHA/ENO1/PDHA1/SLC2A1/PDHB/RBX1/CDKN1B/RPS6KB2/AKT1/EIF4E2/MAP2K2/CAMK2G/PFKP/ALDOA/PIK3CB/ERBB2/MAPK3/PFKL/EGLN3/NOS2/ANGPT1/HK1/CUL2/ARNT/VHL/RPS6KB1/EPO/EGLN1/AKT3/PLCG1/ALDOC/PDK1	1.92605666993787
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	11/2252	27/9376	1.6962041970923	ACAT2/HADH/ECHS1/OXCT1/HMGCS1/L2HGDH/ACSM3/ALDH5A1/AACS/BDH1/EHHADH	2.03677856203824
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	30/2252	93/9376	1.34303558127543	CKS1B/CCNE1/CKS2/SKP2/TRAF4/CDK2/CCNE2/CDK4/LAMA4/E2F1/CDKN1B/PTK2/LAMB1/AKT1/PIK3CB/E2F2/LAMA1/CASP3/GADD45A/LAMC1/NOS2/LAMA5/TRAF2/TP53/E2F3/MYC/COL4A2/CYCS/AKT3/LAMC2	1.86915081484986
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/2252	12/9376	2.08170515097691	COQ3/COQ4/COQ5/VKORC1L1/COQ7/COQ6	2.10802954872611
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	65/2252	224/9376	1.20813245369196	CCNE1/RANBP1/PTTG1/CCNB2/MAD2L1/CDC20/RAN/CCNA2/FDPS/CHEK1/BUB3/CDK2/NFYB/SLC25A6/ANAPC11/SLC25A4/MSX2/BUB1B/VDAC1/CCNE2/CDK4/CCND3/SLC2A1/HRAS/VDAC3/VDAC2/CHEK2/E2F1/HLA-G/ANAPC15/ANAPC5/CDC23/AKT1/CDC27/MAP2K2/XPO1/PIK3CB/E2F2/TBPL1/MAPK9/TCF3/MAPK3/ANAPC13/ESPL1/SLC25A5/KAT2A/ANAPC10/ADCY5/CDC16/ANAPC1/TP53/CRTC3/E2F3/CDKN2A/KAT5/ANAPC4/RANBP3/CREB3L4/MYC/GPS2/ADCY6/TBP/SRF/AKT3/CDKN2C	1.77261199395931
Cellular Processes	Cell motility	hsa04814	Motor proteins	57/2252	194/9376	1.223270037172	TUBB/TUBA1B/KIF23/KIF2C/TUBB4B/KIF11/KIFC1/CENPE/TUBA1C/KIF4A/DYNLL2/TUBG1/TPM2/MYO1B/KIF22/KIF15/TPM1/KIF20B/KIF2A/KIF18A/KIF20A/MYL6B/MYO10/MYL4/TNNI2/KIF14/TUBB6/MYH10/MYL12B/DYNLL1/TPM4/MYO7A/DCTN3/KIF18B/DCTN2/KIF21A/MYO19/DCTN5/DYNC1LI2/DNALI1/MYL9/KIFAP3/KIF3A/DNAH14/TNNC1/ACTG1/TNNT3/DYNLT1/DYNC1I2/MYO1C/TUBE1/KLC2/MYO5C/MYO1D/TUBD1/KIF3C/KIF9	1.76673145505219
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/2252	105/9376	1.30850038061406	RPS27A/BNIP3/PHB2/TOMM40/UBA52/RRAS2/HRAS/EIF2S1/VCP/E2F1/TOMM20/TOMM7/MTX2/PGAM5/SAMM50/UBB/CSNK2A1/MAPK9/MTX1/CSNK2B/HUWE1/CSNK2A2/TRAF2/TP53/RHOT2/SIAH1/OPA1/FUNDC1/MFN1/BCL2L13/FIS1/SMURF1/OPTN	1.78728964445851
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/2252	28/9376	1.63562547576757	ELOVL6/THEM4/HADH/ECHS1/MECR/ACOT7/TECR/PPT2/ELOVL2/ACOT4/ELOVL1	1.89377698830945
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	23/2252	70/9376	1.36797767064197	FH/SLC2A1/BAD/HRAS/RBX1/PAK4/AKT1/MAP2K2/PIK3CB/PTPN11/MAPK3/PAK6/EGLN3/CRKL/PRCC/CUL2/ARNT/GAB1/VHL/EGLN1/AKT3/CDC42/MET	1.737388080722
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	71/2252	250/9376	1.18240852575488	CAV1/ARPC1A/ARPC5L/HRAS/RAB11A/PARD3/VPS25/HLA-G/PARD6B/SNX5/WASL/CAV2/EPN3/SNF8/RAB11FIP4/MVB12A/PRKCZ/EPN2/SH3GL1/NEDD4/SNX6/RAB8A/SH3GLB2/CHMP4C/SNX4/CLTA/HSPA8/SNX2/EPS15L1/VPS26A/RAB11B/RAB4A/RABEP1/ARF5/FOLR1/VPS36/ACTR3B/ZFYVE9/FGFR4/AP2A1/CHMP2A/ARFGAP2/TSG101/CHMP2B/PRKCI/CBLC/SNX3/LDLR/ARF6/VPS29/VTA1/AP2M1/SH3GL3/LDLRAP1/VPS4A/PIP5K1A/STAMBP/VPS4B/STAM/MVB12B/AGAP1/RAB11FIP5/GRK5/CDC42/EHD3/SMURF1/GBF1/GRK6/RAB35/SNX12/PIP5K1C	1.64354947264624
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	16/2252	46/9376	1.44814271372307	HMBS/ALAS2/MMAB/CPOX/COX10/UROS/UROD/FXN/ALAD/CP/HMOX2/HCCS/EARS2/COX15/FECH/PPOX	1.71301951109197
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	6/2252	13/9376	1.92157398551715	FEN1/XRCC6/XRCC5/PRKDC/XRCC4/RAD50	1.86940003809824
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	9/2252	23/9376	1.62916055293845	GPT2/GOT2/ASS1/ARG2/GOT1/CAD/NOS2/ASL/GLUD2	1.69846973336471
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/2252	37/9376	1.46281983582161	HRAS/CDH1/PPARG/MAP2K2/TFG/TPR/MAPK3/GADD45A/CCDC6/TCF7L2/TP53/MYC/TCF7	1.58588070125215
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/2252	41/9376	1.42165229822813	CDK4/HRAS/CDH1/E2F1/MAP2K2/E2F2/ERBB2/MAPK3/MMP2/TP53/DAPK3/E2F3/CDKN2A/MYC	1.52123782315969
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	19/2252	59/9376	1.34075924978174	RRM2/RRM1/GGCT/GSTP1/GPX3/PRDX6/SRM/GSTA4/IDH2/GPX8/IDH1/MGST3/GSS/GCLM/GSTO2/LANCL1/SMS/GGT7/GSTM3	1.47619417537677
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/2252	31/9376	1.47733913940297	RPIA/PGM1/PFKP/ALDOA/GPI/PFKL/TALDO1/TKT/DERA/RPE/ALDOC	1.49667021437864
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	24/2252	78/9376	1.2810493236781	CAV1/ARPC1A/ARPC5L/CTTN/CDH1/CD2AP/PTK2/WASL/CAV2/PIK3CB/DOCK1/VCL/CLTA/PXN/CTNNA1/CRKL/ACTR3B/WASF1/GAB1/ACTG1/CDC42/MET/BCAR1/ELMO3	1.40133816761794
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/2252	21/9376	1.58606106741098	AASDHPPT/BCAT2/PPCDC/PANK2/ALDH1B1/PPCS/COASY/PANK1	1.5116056241042
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	10/2252	28/9376	1.48693225069779	AKR1B1/DHFR/GGH/PTS/PCBD2/QDPR/CBR1/MOCS2/MOCS1/MOCOS	1.45076169284065
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	7/2252	18/9376	1.61910400631537	FASN/CBR4/MECR/ACACA/MCAT/OXSM/HSD17B8	1.4781422218765
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/2252	43/9376	1.35552893551985	ACAT2/ALDH7A1/ADH5/ECI2/ECI1/HADH/ECHS1/ALDH9A1/CPT1C/GCDH/ALDH1B1/ACADSB/CPT2/EHHADH	1.31373092516562
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	35/2252	122/9376	1.19442098826544	HDAC1/SLC2A1/BAD/HRAS/BMP4/MED30/AKT1/HDAC2/MED4/MAP2K2/PFKP/PIK3CB/MAPK3/MED27/PFKL/MED12L/KAT2A/TP53/MED16/HDAC3/THRB/FXYD2/MED17/ACTG1/ATP1A4/PLCD4/MYC/AKT3/TBC1D4/PLCB3/PLCG1/SLC9A1/MED12/SLC16A2/WNT4	1.21525156776941
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	18/2252	59/9376	1.27019297347744	BAD/HRAS/AXIN2/CDH1/AKT1/MAP2K2/PIK3CB/ERBB2/MAPK3/GADD45A/TCF7L2/MLH1/CTNNA1/TP53/MYC/AKT3/TCF7/AXIN1	1.17049586748004
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	49/2252	178/9376	1.14610733031313	CACYBP/RAC3/RUVBL1/CCND3/WNT7A/CUL1/AXIN2/TLE1/LGR4/RBX1/SKP1/FZD3/CAMK2G/CBY1/CSNK2A1/TBL1X/MAPK9/CSNK1E/WNT10B/DVL1/TCF7L2/DVL3/PPARD/CSNK2B/RNF43/CSNK2A2/TP53/SIAH1/RYK/BTRC/SERPINF1/FRAT2/SENP2/LRP5/APCDD1/LRP6/MYC/CTNNBIP1/DVL2/PRICKLE3/PLCB3/TCF7/FZD6/VANGL1/TLE2/CCAR2/AXIN1/WNT4/DKK1	1.10647901012233
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/2252	30/9376	1.38780343398461	TYMS/DHFR/ATIC/SHMT1/ABCG2/GGH/GART/SHMT2/FOLR1/SLC19A1	1.1960993801804
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	40/2252	144/9376	1.15650286165384	DLX5/ID1/DUSP9/HRAS/WNT7A/AXIN2/PCGF6/BMP4/AKT1/FZD3/ID3/MAP2K2/ID4/RIF1/PIK3CB/TCF3/MAPK3/ACVR2B/WNT10B/DVL1/DVL3/PCGF2/FGFR4/MAPK13/TBX3/REST/SMARCAD1/LIFR/MYC/SMAD5/DVL2/MAPK14/AKT3/SETDB1/TCF7/FZD6/PCGF1/AXIN1/WNT4/MEIS1	1.06405360407196
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	24/2252	83/9376	1.20387767767339	POLR2H/POLR2L/POLR2F/POLR3K/POLR2E/G3BP1/POLR1D/POLR2K/IRF3/CASP3/POLR3G/POLR3H/GSDMD/ZCCHC3/POLR3B/FADD/POLR1C/POLR3D/DDX41/POLR3A/POLR3F/POLR3E/MAVS/POLR3C	1.04891097967941
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	25/2252	87/9376	1.19638227067638	UQCRH/COX5A/CYC1/TPM2/TPM1/COX8C/UQCRFS1/COX5B/UQCR10/MYL4/COX7C/COX6C/TPM4/UQCRQ/COX7B/COX7A2/UQCRC2/UQCRC1/COX7A2L/FXYD2/TNNC1/ATP1A4/CACNB3/COX8A/SLC9A1	1.03463055037737
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/2252	87/9376	1.19638227067638	BIRC5/MSH2/RAC3/MSH6/BAD/HRAS/AXIN2/RPS6KB2/AKT1/MAP2K2/PIK3CB/CASP3/MAPK9/MAPK3/GADD45A/TCF7L2/MLH1/TP53/MSH3/RPS6KB1/MYC/CYCS/AKT3/TCF7/AXIN1	1.03463055037737
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	34/2252	122/9376	1.160294674315	CCNA2/FASN/LEP/CAB39L/EEF2/PPARG/PPP2R1A/RPS6KB2/AKT1/ELAVL1/PFKP/PPP2CA/HMGCR/PIK3CB/PPP2R2A/RAB8A/GYS1/PPP2R3B/PFKL/CPT1C/ACACA/RAB11B/PFKFB4/PPP2R3A/STRADB/PPP2R1B/AKT1S1/RAB2A/PRKAB1/RPS6KB1/CREB3L4/AKT3/EEF2K/STK11	1.00194097357655
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/2252	10/9376	1.66536412078153	MPST/SUOX/BPNT1/TST	1.18355972253585
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	42/2252	155/9376	1.12814988827136	CCNE1/CDK2/WDR5/CYP11A1/GNAI1/CCNE2/FH/CDK4/GNAS/WNT7A/AXIN2/E2F1/CDKN1B/HSD3B1/FZD3/MAP2K2/CAMK2G/E2F2/MAPK3/ASH2L/PBX1/WNT10B/DVL1/TCF7L2/DVL3/GNAI3/ADCY5/MEN1/LDLR/E2F3/CDKN2A/ARNT/CREB3L4/ADCY6/DVL2/GNA11/CDKN2C/PLCB3/TCF7/FZD6/AXIN1/WNT4	0.904488284223424
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	18/2252	62/9376	1.20873202314788	HDAC1/SOD1/HRAS/RPS6KB2/AKT1/HDAC2/PIK3CB/HSPA8/EIF4EBP2/CLPB/ADCY5/AKT1S1/ATG5/PRKAB1/RPS6KB1/ADCY6/AKT3/CRYAB	0.92709595539474
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	66/2252	253/9376	1.0861070352923	RPS27A/BNIP3/ARPC1A/U2AF1/ARPC5L/CBX3/UBA52/CTTN/VDAC1/UBE2N/CUL1/UBE2V2/GLMN/FNBP1L/RBX1/UBE2D2/SKP1/PTK2/WASL/RPS6KB2/FOXO4/RRAGA/PPID/AKT1/MYL12B/IRF3/PIK3CB/DOCK1/UBB/CAPN1/MAPK9/VCL/MAPK3/FOXO6/PXN/ATG12/CRKL/ACTR3B/WASF1/ACTN4/PFN1/TRAF2/MAPK13/WIPI2/MYL9/UBE2V1/TP53/AKT1S1/ATG5/HK1/ARF6/BTRC/RBCK1/ACTG1/RPS6KB1/PLCD4/TIFA/CYCS/GSK3A/MAPK14/AKT3/PLCB3/CDC42/PLCG1/BCAR1/ATG14	0.780616875268412
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	54/2252	205/9376	1.09670320149027	CCNE1/RANBP1/CDK1/CDC20/CCNA2/CHEK1/SKP2/CDK2/YWHAQ/HDAC1/CCNE2/CDK4/CCND3/BAD/HRAS/VDAC3/YWHAE/DDB1/PSMC1/MRPS18B/HLA-G/DNAJA3/CDKN1B/HNRNPK/SNW1/HDAC2/GTF2H3/IRF3/PIK3CB/PKM/GTF2A2/TBPL1/CASP3/GTF2H2/MAPK3/PXN/RBL1/GTF2B/ACTN4/KAT2A/TRAF2/TP53/SND1/HDAC3/YWHAB/CDKN2A/GTF2E2/CREB3L4/TBP/SRF/GTF2H2C/CDC42/YWHAZ/GTF2H1	0.787077163683749
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	40/2252	150/9376	1.11024274718769	CCNE1/CDK2/CCNE2/HRAS/WNT7A/AXIN2/CDH1/E2F1/JUP/CDKN1B/RPS6KB2/AKT1/FZD3/MAP2K2/PIK3CB/E2F2/ERBB2/MAPK3/GADD45A/WNT10B/DVL1/TCF7L2/DVL3/MLH1/CTNNA1/TP53/FRAT2/E2F3/GAB1/LRP5/RPS6KB1/LRP6/MYC/DVL2/AKT3/TCF7/FZD6/MET/AXIN1/WNT4	0.765238492276424
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2252	18/9376	1.38780343398461	CD320/MMAB/MMADHC/ZNF143/MTRR/MMACHC	0.925900371688657
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	42/2252	158/9376	1.10672932077253	RPS6/SKP2/ATP6V1C2/HRAS/WNT7A/EIF4B/CAB39L/RPS6KB2/RRAGA/AKT1/FZD3/EIF4E2/MAP2K2/ATP6V1B1/SEC13/PIK3CB/SLC38A9/SEH1L/MAPK3/WNT10B/DVL1/DVL3/MLST8/STRADB/TELO2/ATP6V1E1/AKT1S1/TBC1D7/NPRL3/TTI1/PRR5/LRP5/LAMTOR5/RPS6KB1/LRP6/DVL2/NPRL2/AKT3/FZD6/STK11/WDR59/WNT4	0.760679676376556
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	27/2252	99/9376	1.1354755368965	CDK4/BAD/HRAS/GNAS/E2F1/CDKN1B/PTK2/RPS6KB2/AKT1/MAP2K2/PIK3CB/E2F2/ERBB2/MAPK9/MAPK3/MMP2/MAPK13/ADCY5/TP53/CARM1/E2F3/CDKN2A/RPS6KB1/ADCY6/MAPK14/AKT3/CDKN2C	0.761872987403736
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/2252	116/9376	1.11263551172904	JAM3/CLDN7/GNAI1/CLDN10/CLDN6/CLDN4/CDH5/EZR/PTK2/CLDN3/MYL12B/PIK3CB/PTPN11/VCL/PXN/CTNND1/CTNNA1/MMP2/ACTN4/GNAI3/MAPK13/MYL9/ACTG1/VAV3/VAV2/MAPK14/OCLN/CDC42/PLCG1/BCAR1/ARHGAP5	0.686288487498541
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/2252	34/9376	1.22453244175112	CUL1/RBX1/SKP1/CSNK1E/BTRC/PRKAB1/RORB/CRY1/PER2/RORA	0.737405720218389
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	20/2252	73/9376	1.14066035669968	RAN/PSIP1/PPIA/NELFCD/SMARCB1/CPSF6/NELFE/XPO1/PIN1/NELFB/KAT2A/NUP153/TSG101/NELFA/VPS4A/VPS4B/TRIM5/TNPO3/MLLT1/APOBEC3B	0.678312015077642
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	21/2252	77/9376	1.1354755368965	RAD51/RAC3/CDK4/BAD/E2F1/RALBP1/RPS6KB2/AKT1/PIK3CB/E2F2/ERBB2/MAPK9/BRCA2/MAPK3/GADD45A/TP53/E2F3/CDKN2A/RPS6KB1/AKT3/CDC42	0.671113531444615
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/2252	77/9376	1.1354755368965	HDAC1/CDK4/BAD/HRAS/E2F1/CDKN1B/AKT1/HDAC2/MAP2K2/PIK3CB/E2F2/PTPN11/MAPK3/GADD45A/CRKL/TP53/E2F3/CDKN2A/BCR/MYC/AKT3	0.671113531444615
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/2252	42/9376	1.18954580055823	ACAT2/ALDH7A1/DHTKD1/AADAT/HADH/ECHS1/DLD/ALDH9A1/DLST/GCDH/ALDH1B1/EHHADH	0.692170028008079
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	45/2252	174/9376	1.07674404360875	HSP90AB1/TUSC3/RAD23B/EIF2S1/CUL1/VCP/RBX1/UBE2D2/BAG2/SKP1/DNAJA2/NSFL1C/UBXN2A/MAN1A2/UBE2J2/HSPBP1/SEC13/SAR1A/CAPN1/BAG1/TMEM258/LMAN1/MAPK9/PDIA6/RAD23A/HSPA8/WFS1/UBXN4/OSTC/UBE2G1/SVIP/STT3A/TRAF2/DDOST/PLAA/ERLEC1/PREB/HSPA4L/MOGS/HSPA5/RNF5/SSR2/UBE4B/CRYAB/TXNDC5	0.574494749414052
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2252	27/9376	1.23360305243076	ELOVL6/ACOT7/FADS1/TECR/ELOVL2/ACOT4/ELOVL1/FADS2	0.683416864197089
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	21/2252	78/9376	1.12091815821834	IMPA2/TPI1/ISYNA1/PIK3CB/IP6K2/INPP4B/PI4K2B/MTMR1/INPP5A/SYNJ1/ITPKA/PIP5K1A/PLCD4/PIK3C2G/MTMR4/PLCB3/MTMR2/PLCG1/INPP5F/ALDH6A1/PIP5K1C	0.602909226223569
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	23/2252	86/9376	1.11347019703416	BAD/HRAS/CDKN1B/PTK2/RPS6KB2/PAK4/AKT1/ERBB3/MAP2K2/CAMK2G/PIK3CB/ERBB2/MAPK9/MAPK3/PAK6/CRKL/NCK2/GAB1/RPS6KB1/MYC/NRG4/AKT3/PLCG1	0.594334654012564
NA	NA	hsa04981	Folate transport and metabolism	9/2252	31/9376	1.20873202314788	TYMS/DHFR/SHMT1/ABCG2/MTHFD1/SHMT2/MTHFS/FOLR1/SLC19A1	0.654467601846283
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	52/2252	204/9376	1.06126144951764	RPS6/CAV1/RRAS2/CTTN/HRAS/WNT7A/PPP1CC/GPC1/EIF4B/EZR/PTK2/PPP1CA/CAV2/RPS6KB2/AKT1/ERBB3/FZD3/MAP2K2/CAMK2G/PIK3CB/RDX/ERBB2/CASP3/PTPN11/MAPK3/ANK3/PXN/WNT10B/NUDT16L1/MMP2/MAPK13/TP53/TFAP4/PPP1CB/GAB1/PDCD4/ACTG1/RPS6KB1/MYC/ARHGEF12/VAV3/VAV2/MAPK14/AKT3/CDC42/FZD6/MET/PLCG1/SLC9A1/DROSHA/ANK1/WNT4	0.497368418223531
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	52/2252	205/9376	1.05608456439804	CCNE1/CCNA2/SKP2/CDK2/PSMC3/PSMD12/HDAC1/CCNE2/CDK4/PSMC5/CCND3/PSMD11/PSMD4/PSMD6/PSMD14/E2F1/PSMD13/PSMC1/PSMD2/HLA-G/PSMC4/CDKN1B/ADRM1/PSMC6/SNW1/AKT1/PSMD7/HDAC2/PSMD1/PSMD3/PSMD8/IRF3/PIK3CB/NEDD4/E2F2/CASP3/MAPK9/GADD45A/MAP2K6/FADD/SAP30/TRAF2/MAPK13/PSMC2/TP53/E2F3/MYC/SAP30L/CYCS/MAPK14/AKT3/MAVS	0.456477957219326
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/2252	32/9376	1.17095914742451	AKR1B1/UGP2/PGM1/PFKP/GALT/PFKL/B4GALT2/GALE/HK1	0.544639071267356
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/2252	44/9376	1.1354755368965	TUSC3/MAN1A2/TMEM258/B4GALT3/B4GALT2/FUT8/OSTC/STT3A/DDOST/ALG14/ALG12/ALG9	0.506416363017662
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/2252	17/9376	1.22453244175112	SEPHS1/TXNRD3/TXNRD2/SCLY/PSTK	0.520950803495327
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/2252	21/9376	1.18954580055823	CHST14/DSEL/CHPF/CHSY1/XYLT1/CHST12	0.488888469276593
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/2252	33/9376	1.1354755368965	BET1/BNIP1/VTI1B/SNAP29/STX17/USE1/GOSR2/STX18/YKT6	0.438311183922775
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	21/2252	82/9376	1.0662392236711	RRM2/DUT/RRM1/TK1/IMPDH2/GSTP1/GMPS/GSTA4/UMPS/NME1/MGST3/NME2/NME6/UCK1/GSTO2/UCK2/ITPA/CMPK1/NME1-NME2/UCKL1/GSTM3	0.338710532682936
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	53/2252	214/9376	1.03112498132501	CCNB1/CDK1/CCNB2/CHEK1/AP1M2/RAC3/WEE1/CALM1/GNAI1/CFL2/BAD/HRAS/GNG12/AP1S1/CUL1/CDC25C/DDB1/HLA-G/RBX1/SKP1/PTK2/RPS6KB2/PAK4/GNB5/AKT1/MAP2K2/CALM2/IRF3/PIK3CB/CASP3/MAPK9/MAPK3/PAK6/PXN/MAP2K6/FADD/CRKL/GNG4/GNAI3/TRAF2/MAPK13/AP1S3/LIMK2/BTRC/GNB2/RPS6KB1/TRIM5/GNA11/CYCS/MAPK14/AKT3/PLCG1/APOBEC3B	0.258957633970709
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/2252	14/9376	1.18954580055823	B4GALT4/B4GALT3/B4GALT2/FUT8	0.399026503159243
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	34/2252	137/9376	1.03325511143379	BIRC5/LMNB1/TUBA1B/LMNB2/PARP1/TUBA1C/CTSV/DFFA/BAD/HRAS/EIF2S1/PARP2/AKT1/MAP2K2/CASP6/PIK3CB/ENDOG/CASP3/CAPN1/MAPK9/MAPK3/HTRA2/GADD45A/FADD/AIFM1/TRAF2/CASP2/TP53/DFFB/DAXX/ACTG1/CYCS/AKT3/DIABLO	0.220452020375806
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	16/2252	63/9376	1.05737404494065	WNT7A/AXIN2/BMP4/FZD3/GADD45A/WNT10B/DVL1/TCF7L2/DVL3/TP53/GLI3/DVL2/TCF7/FZD6/AXIN1/WNT4	0.256890958047521
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	34/2252	138/9376	1.02576775555384	RPS6/CALM1/PYGL/FASN/BAD/HRAS/PPP1CC/PPP1CA/RPS6KB2/AKT1/EIF4E2/MAP2K2/SH2B2/PRKCZ/CALM2/PIK3CB/MAPK9/MAPK3/GYS1/FLOT2/ACACA/CRKL/PPP1R3B/INPP5A/PRKCI/PHKG2/HK1/PPP1CB/PRKAB1/RPS6KB1/SOCS2/PHKA2/AKT3/TRIP10	0.171449029866485
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/2252	31/9376	1.07442846502034	ALDH7A1/ECHS1/ALDH9A1/ALDH1B1/HIBCH/ALDH3B2/ALDH6A1/EHHADH	0.233366295580105
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	27/2252	110/9376	1.02192798320685	TFDP1/ID1/BMP7/HDAC1/CUL1/RBX1/PPP2R1A/BMP4/SKP1/RPS6KB2/ID3/E2F4/HDAC2/ID4/PPP2CA/MAPK3/ACVR2B/LRRC32/E2F5/RBL1/ZFYVE9/PPP2R1B/GREM2/RPS6KB1/MYC/SMAD5/SMURF1	0.130063896458261
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/2252	23/9376	1.0861070352923	B4GALT3/B4GALT2/CHST10/B3GALNT2/MGAT5B/POMK	0.232452897103432
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	26/2252	106/9376	1.02121384764905	CCNE1/GSTP1/HSP90AB1/CDK2/CCNE2/BAD/HRAS/E2F1/CDKN1B/AKT1/MAP2K2/PIK3CB/E2F2/ERBB2/MAPK3/ETV5/TCF7L2/FOLR1/TP53/SLC19A1/E2F3/SPINT1/CREB3L4/PDGFA/AKT3/TCF7	0.123492444376011
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	38/2252	156/9376	1.01416404791183	CDK2/CLDN7/YWHAQ/CLDN10/EIF3E/CLDN6/CDK4/BAD/HRAS/EIF2S1/CLDN4/YWHAE/E2F1/PPP2R1A/AKT1/MAP2K2/CLDN3/PPP2CA/IRF3/PIK3CB/PPP2R2A/E2F2/CASP3/PSME3/MAPK3/FADD/PPP2R1B/TRAF2/TP53/LDLR/YWHAB/E2F3/MYC/CYCS/AKT3/OCLN/YWHAZ/MAVS	0.100297960432064
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/2252	44/9376	1.04085257548845	DYNLL2/RAB11A/GNAS/DYNLL1/DCTN2/RAB11B/DCTN5/DYNC1LI2/DYNC1I2/CREB3L4/ADCY6	0.152709582650141
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/2252	36/9376	1.04085257548845	PYGL/UGP2/PGM1/GYG2/AGL/GPI/GYS1/GBE1/HK1	0.13807184535992
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	26/2252	107/9376	1.01166979299812	LDHB/LDHA/PRMT1/CALM1/PYGL/PDHA1/SLC2A1/PGAM1/GNAS/PDHB/AKT1/CAMK2G/PFKP/CALM2/PKM/GYS1/PFKL/CPT1C/ACACA/PPP4C/PHKG2/PRKAB1/CREB3L4/PHKA2/AKT3/PLCB3	0.0682568867904173
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	49/2252	203/9376	1.00496110736816	CAV1/RAC3/PGF/CCND3/BAD/HRAS/PARVA/PPP1CC/LAMA4/COL9A3/PTK2/PPP1CA/CAV2/PAK4/LAMB1/AKT1/MYL12B/PIK3CB/DOCK1/ERBB2/LAMA1/MAPK9/VCL/MAPK3/PAK6/PXN/CRKL/LAMC1/EMP2/ACTN4/LAMA5/ITGB4/MYL9/PPP1CB/ACTG1/PIP5K1A/FLT4/COL4A2/VAV3/VAV2/PDGFA/RASGRF1/AKT3/CDC42/MET/BCAR1/ARHGAP5/LAMC2/PIP5K1C	0.0401771220398903
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2252	28/9376	1.04085257548845	ST3GAL4/B4GALT4/B4GALT3/B4GALT2/A4GALT/B3GALNT1/ST8SIA1	0.12171580643426
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/2252	16/9376	1.04085257548845	MIF/GOT2/GOT1/ALDH3B2	0.0919495025472168
NA	NA	hsa04519	Cadherin signaling	96/2252	404/9376	0.989325220266254	KRT19/PKP3/KRT7/TEAD4/RAC3/ENAH/ARPC1A/CIB2/ARPC5L/KRT23/KRT18/YWHAQ/YAP1/RRAS2/DSP/MYO1B/HRAS/WNT7A/DSC2/KRT8/YWHAE/PPP1CC/PKP2/AXIN2/DSG2/CDH1/LIMA1/JUP/CDH5/TEAD3/NCKAP1/PTK2/DSC3/PPP1CA/KRT10/WWTR1/FZD3/MAP2K2/MYO7A/ERBB2/WTIP/MAPK9/VCL/MAPK3/MPDZ/CTNND1/TJP1/WNT10B/DVL1/TCF7L2/DVL3/RERE/STK3/CTNNA1/KRT80/TEAD1/ACTR3B/WASF1/ACTN4/AMOTL1/KRT24/MAPK13/RYK/AMOTL2/YWHAB/CYFIP2/PPP1CB/TMC5/LRP5/ACTG1/KRT33B/FAT2/TEAD2/CDH3/LRP6/FLT4/MYO1C/VAV3/VAV2/DVL2/ABI2/PRICKLE3/MAPK14/CDC42/FAT1/MYO1D/TCF7/FZD6/MET/YWHAZ/VANGL1/SAV1/AXIN1/WNT4/AJUBA/GABRE	-0.123314131470028
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/2252	76/9376	0.986070860989062	CALM1/CDK4/HRAS/E2F1/AKT1/MAP2K2/CAMK2G/CALM2/PIK3CB/E2F2/MAPK3/GADD45A/TP53/E2F3/CDKN2A/PDGFA/AKT3/PLCG1	-0.0685484233701851
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	35/2252	148/9376	0.9845902741107	CDK4/HRAS/WNT7A/BRCA1/AXIN2/E2F1/RPS6KB2/AKT1/FZD3/MAP2K2/PIK3CB/E2F2/ERBB2/BRCA2/MAPK3/HEY1/GADD45A/WNT10B/DVL1/TCF7L2/DVL3/TP53/FRAT2/E2F3/LRP5/RPS6KB1/LRP6/FLT4/MYC/DVL2/AKT3/TCF7/FZD6/AXIN1/WNT4	-0.106237992155182
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/2252	38/9376	0.986070860989062	QPRT/PNP/NT5C/NT5M/NMRK1/NNMT/NADK2/SIRT5/SIRT3	-0.0483723305579884
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/2252	68/9376	0.979625953400899	CCNA2/BAD/HRAS/JUP/RPS6KB2/AKT1/MAP2K2/PIK3CB/MAPK3/TCF7L2/PPARD/RPS6KB1/MYC/AKT3/TCF7/PER2	-0.094800677283034
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	23/2252	98/9376	0.977126907601406	ARPC1A/ARPC5L/CFL2/MARCKSL1/MYO10/RPS6KB2/AKT1/PIK3CB/DOCK1/MAPK3/CRKL/ACTR3B/WASF1/LIMK2/ARF6/PIP5K1A/RPS6KB1/VAV3/VAV2/AKT3/CDC42/PLCG1/PIP5K1C	-0.127973077504007
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	47/2252	200/9376	0.978401420959147	GAPDH/RPS3/NCL/TUBB/TUBA1B/TUBB4B/ARPC1A/TUBA1C/CLDN7/ARPC5L/CLDN10/CTTN/MYO1B/CLDN6/CLDN4/BAIAP2L1/MYO10/NCKAP1/EZR/WASL/ABCF2/TUBB6/MYH10/CLDN3/CASP3/PTPN11/MAPK9/MAPK3/TJP1/FADD/ACTR3B/WASF1/NCK2/TRAF2/MAPK13/ARF6/CYFIP2/ACTG1/MYO1C/ARHGEF12/CYCS/MAPK14/OCLN/CDC42/MYO5C/MYO1D/GNA12	-0.173588660274653
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/2252	60/9376	0.971462403789225	RAC3/BAD/HRAS/PTK2/AKT1/MAP2K2/PIK3CB/MAPK3/PXN/MAPK13/MAPK14/AKT3/CDC42/PLCG1	-0.124676944353199
Human Diseases	Cancer: specific types	hsa05218	Melanoma	17/2252	73/9376	0.969561303194725	CDK4/BAD/HRAS/CDH1/E2F1/AKT1/MAP2K2/PIK3CB/E2F2/MAPK3/GADD45A/TP53/E2F3/CDKN2A/PDGFA/AKT3/MET	-0.146785734451156
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	17/2252	73/9376	0.969561303194725	CDK4/BAD/HRAS/E2F1/AKT1/MAP2K2/PIK3CB/E2F2/ERBB2/MAPK3/GADD45A/TP53/E2F3/CDKN2A/AKT3/MET/PLCG1	-0.146785734451156
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/2252	56/9376	0.966505962953565	HSPD1/EEF1A1/BNIP3/VCP/HBS1L/SAR1A/CASP3/HSPA8/RAB1B/HSF1/EEF1G/BCL2L13/CYCS	-0.141338809707781
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/2252	133/9376	0.970418942560665	CALM1/GNAI1/GNG12/GNAS/PPP1CC/PPP2R1A/PPP1CA/GNB5/AKT1/CAMK2G/PPP2CA/CALM2/PPP2R2A/COMT/MAPK9/PPP2R3B/GNG4/GNAI3/PPP2R3A/PPP2R1B/MAPK13/ADCY5/SLC18A2/PPP1CB/LRTOMT/GNB2/CREB3L4/GSK3A/MAPK14/AKT3/PLCB3	-0.193170549222601
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/2252	142/9376	0.96755309834138	GSTP1/CAV1/HSP90AB1/RAC3/GSTA4/CALM1/TXN2/GPC1/MGST3/CDH5/SUMO2/BMP4/PTK2/CAV2/AKT1/PRKCZ/ASS1/CALM2/PIK3CB/MAPK9/GSTO2/ACVR2B/SUMO1/MAP2K6/MMP2/TXN/MAPK13/TP53/ACTG1/PDGFA/MAPK14/AKT3/GSTM3	-0.219043487514504
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	29/2252	125/9376	0.965911190053286	RAC3/GNAI1/HRAS/SPTSSA/PPP2R1A/AKT1/MAP2K2/PRKCZ/PPP2CA/PIK3CB/PPP2R2A/MAPK9/MAPK3/PPP2R3B/CERS5/GNAI3/PPP2R3A/PPP2R1B/TRAF2/MAPK13/TP53/SMPD2/SPTLC1/MAPK14/AKT3/PLCB3/GNA12/ORMDL3/SPTLC3	-0.215715018224294
NA	NA	hsa03272	Virion - Hepatitis viruses	11/2252	48/9376	0.954114860864417	CLDN7/EPCAM/CLDN10/CLDN6/CLDN4/CLDN3/TSG101/LDLR/VPS4A/VPS4B/OCLN	-0.179186909379832
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	54/2252	232/9376	0.969069639247872	DIAPH3/RAC3/ENAH/ARPC1A/ARPC5L/RRAS2/CFL2/HRAS/GNG12/PPP1CC/NCKAP1/EZR/PTK2/WASL/PPP1CA/PAK4/AKT1/MAP2K2/MYH10/MYL12B/PIK3CB/RDX/DOCK1/VCL/MAPK3/PAK6/PXN/ITGAE/CRKL/ACTR3B/WASF1/ACTN4/PFN1/FGFR4/ITGB4/MYL9/LIMK2/FGD1/CYFIP2/PPP1CB/ACTG1/PIP5K1A/TMSB4Y/ARHGEF12/VAV3/VAV2/PDGFA/ABI2/AKT3/CDC42/GNA12/BCAR1/SLC9A1/PIP5K1C	-0.268206158002746
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/2252	101/9376	0.948103336088493	CALM1/GNAI1/HRAS/GNAS/WNT7A/FZD3/MAP2K2/CAMK2G/CALM2/MAPK3/WNT10B/DVL1/TCF7L2/DVL3/GNAI3/ADCY5/CREB3L4/ADCY6/DVL2/PLCB3/TCF7/FZD6/WNT4	-0.294815996622805
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/2252	80/9376	0.936767317939609	RPS6/BAD/HRAS/RPS6KB2/AKT1/ERBB3/EIF4E2/MAP2K2/PIK3CB/ERBB2/MAPK3/NF1/GAB1/RPS6KB1/PDGFA/AKT3/MET/PLCG1	-0.319334922031187
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	42/2252	184/9376	0.950343655880763	RAC3/ENAH/GNAI1/BMP7/CFL2/HRAS/PARD3/EPHB4/EFNA1/PARD6B/PTK2/EFNA4/PAK4/FZD3/CAMK2G/ROBO1/PRKCZ/MYL12B/PIK3CB/PTPN11/MAPK3/PAK6/GNAI3/NCK2/SEMA4B/MYL9/SEMA7A/EPHB3/LIMK2/RYK/RASA1/SRGAP1/ARHGEF12/SEMA6A/CDC42/RHOD/MET/PLCG1/PLXNB1/BOC/EFNA3/WNT4	-0.38246044112985
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/2252	32/9376	0.910746003552398	ATG10/PPP2CA/ATG12/MLST8/IGBP1/WIPI2/ATG5	-0.28434403460971
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/2252	32/9376	0.910746003552398	BIRC5/CASP3/MAPK9/HTRA2/FADD/CYCS/DIABLO	-0.28434403460971
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2252	23/9376	0.905089196076917	CA2/MDH1/FXYD2/ATP1A4/GLUD2	-0.256219381650329
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	30/2252	133/9376	0.939115105703869	CCNB1/CCNB2/SKP2/BNIP3/PRMT1/PLK1/CDK2/HRAS/CDKN1B/FOXO4/AKT1/PLK4/MAP2K2/PIK3CB/HOMER1/CCNG2/MAPK9/MAPK3/FOXO6/PLK2/CSNK1E/GADD45A/ATG12/MAPK13/PRKAB1/SGK2/CDKN2D/MAPK14/AKT3/STK11	-0.397591211695638
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	8/2252	37/9376	0.900196822044069	MIF/ADH5/GSTZ1/GOT2/COMT/GOT1/LRTOMT/ALDH3B2	-0.341981742340339
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	19/2252	86/9376	0.919823206245611	DSP/DSC2/PKP2/DSG2/JUP/SGCB/SGCE/DAG1/LAMA1/EMD/SSPN/TCF7L2/CTNNA1/ITGB4/ACTG1/CACNB3/SNTB2/TCF7/DMD	-0.419950332522165
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/2252	51/9376	0.897990457284157	ATP6V1C2/GNAS/ATP6V1B1/TJP2/TJP1/KDELR1/ATP6V1E1/ACTG1/KDELR2/PLCG1/KDELR3	-0.41068547623483
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/2252	70/9376	0.892159350418675	CAV1/RAC3/HLA-G/SGCB/SGCE/DAG1/LAMA1/CASP3/SSPN/EIF4G1/CD55/ACTG1/SNTB2/CYCS/DMD	-0.509164207907082
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/2252	154/9376	0.919194482249544	CALM1/GNAI1/TPM2/TPM1/GNAS/PPP1CC/MYL4/PPP2R1A/PPP1CA/AKT1/CAMK2G/PPP2CA/CALM2/TPM4/PPP2R2A/MAPK3/PPP2R3B/GNAI3/PPP2R3A/PPP2R1B/MAPK13/ADCY5/FXYD2/PPP1CB/TNNC1/ATP1A4/CREB3L4/CACNB3/ADCY6/MAPK14/AKT3/PLCB3/ATP2B3/SLC9A1	-0.568455790419757
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/2252	30/9376	0.832682060390764	PGAP2/DPM2/PIGX/PIGU/PIGF/PIGW	-0.516057534105315
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/2252	98/9376	0.892159350418675	IMPA2/CALM1/CALM2/PIK3CB/IP6K2/INPP4B/PI4K2B/MTMR1/INPP5A/SYNJ1/ITPKA/PIP5K1A/PLCD4/PIK3C2G/CDS1/MTMR4/PLCB3/MTMR2/PLCG1/INPP5F/PIP5K1C	-0.603359596789891
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	30/2252	138/9376	0.905089196076917	RAC3/ARPC1A/ARPC5L/PTK2/WASL/AKT1/MAP2K2/IRF3/PIK3CB/DOCK1/MAPK9/MAPK3/PXN/MAP2K6/CRKL/ACTR3B/TRAF2/MAPK13/ARF6/ACTG1/PIP5K1A/ARHGEF12/VAV3/VAV2/MAPK14/AKT3/CDC42/PLCG1/BCAR1/PIP5K1C	-0.631501072045688
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	37/2252	169/9376	0.911515864924801	HMGB1/RPS27A/BNIP3/UBA52/RRAS2/BAD/HRAS/EIF2S1/RPS6KB2/RRAGA/AKT1/MAP2K2/ATG10/PPP2CA/PIK3CB/UBB/RAB8A/MAPK9/MAPK3/ATG12/MLST8/GORASP2/SNAP29/IGBP1/WIPI2/WDR45B/AKT1S1/STX17/ATG5/DAPK3/RPS6KB1/MTMR4/AKT3/YKT6/STK11/OPTN/ATG14	-0.652615774028447
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2252	16/9376	0.780639431616341	A4GALT/B3GALNT1/ST8SIA1	-0.493728850633968
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2252	26/9376	0.800655827298811	SLC5A6/SLC19A1/AMN/SLC19A3/MMACHC	-0.572258548783407
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/2252	69/9376	0.844749916338456	RAC3/HRAS/AKT1/MAP2K2/PIK3CB/MAPK9/MAPK3/MAP2K6/MAPK13/VAV3/VAV2/MAPK14/AKT3/PLCG1	-0.727711783299952
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/2252	60/9376	0.832682060390764	GNAI1/HRAS/GNAS/PPP2R1A/MAP2K2/PPP2CA/MAPK3/GNAI3/PPP2R1B/GNA11/PLCB3/GNA12	-0.730989719382036
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/2252	212/9376	0.903381480612621	RAC3/ENAH/CALM1/GNAI1/ID1/PGF/HRAS/PARD3/GNAS/CDH1/EFNA1/PARD6B/EFNA4/AKT1/MAP2K2/PRKCZ/CALM2/PIK3CB/MAPK3/CTNND1/MAP2K6/CRKL/PFN1/GNAI3/FGFR4/ANGPT1/MAPK13/ADCY5/PRKCI/KRIT1/MAGI3/ACTG1/FLT4/ADCY6/VAV3/VAV2/PDGFA/MAPK14/AKT3/PLCB3/CDC42/MET/PLCG1/BCAR1/EFNA3/SIPA1L1	-0.800006736551909
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/2252	22/9376	0.756983691264331	ALDH7A1/ALDH9A1/ALDH1B1/ALDH3B2	-0.64158758776195
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/2252	17/9376	0.734719465050674	CA2/CA12/GLUD2	-0.615492829257624
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/2252	37/9376	0.78767221928856	HBA2/HBA1/THOP1/LAMA4/HBB/PLCB3/F2RL1	-0.727554231058836
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/2252	42/9376	0.793030533705489	VDAC3/VDAC2/GSS/GCLM/CP/TP53/ATG5/SLC39A14	-0.755796545531357
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	19/2252	93/9376	0.850589201474436	CGA/CALM1/HRAS/GNAS/MAP2K2/MAP3K4/CAMK2G/CALM2/MAPK9/MAPK3/MAP2K6/MMP2/MAPK13/ADCY5/ADCY6/GNA11/MAPK14/PLCB3/CDC42	-0.814117634016503
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/2252	89/9376	0.842038038597402	CDK1/TUBB/TUBA1B/TUBB4B/TUBA1C/GNAI1/HRAS/GNAS/TUBB6/MAP2K2/MAPK3/TJP1/GNAI3/ADCY5/ADCY6/PDGFA/GNA11/PLCB3	-0.841816965733524
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/2252	52/9376	0.800655827298811	CGA/CYP11A1/GNAS/HSD3B1/CYP2J2/ADCY5/LDLR/ACOT4/HSD17B7/ADCY6	-0.810423377156988
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	73/2252	333/9376	0.91269955568357	CCNE1/CCNA2/CDK2/TUBG1/HDAC1/ATP6V1C2/CCNE2/CDK4/CCND3/BAD/HRAS/PARD3/GNAS/WNT7A/AXIN2/LAMA4/E2F1/PSMC1/HLA-G/COL9A3/PPP2R1A/CDKN1B/PARD6B/PTK2/RPS6KB2/LAMB1/AKT1/FZD3/HDAC2/MAP2K2/ATP6V1B1/PRKCZ/PPP2CA/IRF3/PIK3CB/PPP2R2A/PKM/TBPL1/LAMA1/CASP3/MAPK3/HEY1/DLG3/PPP2R3B/PXN/WNT10B/DVL1/TCF7L2/DVL3/FADD/RBL1/LAMC1/PPP2R3A/LAMA5/PPP2R1B/ITGB4/TP53/PRKCI/ATP6V1E1/CRB3/RPS6KB1/CREB3L4/COL4A2/TBP/DVL2/AKT3/CDC42/TCF7/FZD6/HES6/AXIN1/LAMC2/WNT4	-0.9119902204556
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/2252	76/9376	0.821725717490885	CALM1/GNAI1/GAST/GNAS/EZR/CA2/CAMK2G/CALM2/GNAI3/ADCY5/ACTG1/ATP1A4/ADCY6/PLCB3/SLC9A1	-0.877327807831827
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/2252	90/9376	0.832682060390764	HRAS/PPARG/RPS6KB2/AKT1/EIF4E2/PIK3CB/EHMT1/ADCY5/TP53/AKT1S1/ATG5/PRKAB1/RPS6KB1/CREB3L4/ADCY6/EHMT2/AKT3/STK11	-0.896720914145029
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/2252	53/9376	0.785549113576192	RAB11A/GNAS/CLTA/AP2A1/FXYD2/AP2M1/ATP1A4/ADCY6/PLCB3/ATP2B3	-0.880229286963577
NA	NA	hsa04518	Integrin signaling	32/2252	154/9376	0.865124218587807	RAC3/FERMT1/PGF/FERMT2/CCND3/PARVA/LAMA4/CDH1/COL9A3/PTK2/LAMB1/AKT1/PIK3CB/ERBB2/LAMA1/VCL/PXN/ITGAE/LAMC1/ACTN4/LAMA5/NCK2/ITGB4/ACTG1/FLT4/COL4A2/PDGFA/AKT3/ICAM3/CDC42/MET/LAMC2	-0.948832716695495
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	22/2252	109/9376	0.840321345348477	PYGL/SLC2A1/PPP1CC/SLC27A6/PPP1CA/RPS6KB2/AKT1/PRKCZ/SLC27A2/PIK3CB/PTPN11/MAPK9/GYS1/PPP1R3B/GFPT1/PPP1CB/PRKAB1/RPS6KB1/CREB3L4/AKT3/TBC1D4/TRIB3	-0.942754053151352
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	53/2252	248/9376	0.889761072594969	GAPDH/RPS3/TUBB/TUBA1B/TUBB4B/HSP90AB1/CSE1L/ARPC1A/TUBA1C/ARPC5L/DYNLL2/FBXO22/TXN2/HRAS/NCKAP1/SKP1/WASL/AKT1/TUBB6/MAP2K2/MYL12B/PIK3CB/DYNLL1/DCTN3/CASP3/MAPK9/MAPK3/DCTN2/GSDMD/TCF7L2/MAP2K6/FADD/DCTN5/DYNC1LI2/ACTR3B/PFN1/TXN/TRAF2/MAPK13/MYL9/ARF6/CYFIP2/ACTG1/DYNLT1/DYNC1I2/MYC/PIK3C2G/CYCS/MAPK14/AKT3/KLC2/CDC42/TCF7	-0.989192647394283
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/2252	24/9376	0.693901716992303	EXTL2/XYLT1/HS6ST2/HS6ST1	-0.844154891189708
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/2252	69/9376	0.784410636599995	CALM1/HDAC1/GNAS/PPP1CC/PPP1CA/HDAC2/CAMK2G/CALM2/ADCY5/SLC18A2/PPP1CB/CREB3L4/GRIN2D	-1.01054322419783
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	33/2252	163/9376	0.842899018186969	CCNE1/PCNA/BIRC5/CCNA2/CDK2/YWHAQ/CCNE2/BAD/HRAS/VDAC3/DDB1/E2F1/AKT1/MAP2K2/IRF3/PIK3CB/E2F2/CASP3/MAPK9/MAPK3/MAP2K6/FADD/MAPK13/TP53/YWHAB/E2F3/CREB3L4/MYC/CYCS/MAPK14/AKT3/YWHAZ/MAVS	-1.13757500662449
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	24/2252	122/9376	0.819031534810587	CDK4/HRAS/PPP2R1A/PAK4/AKT1/MAP2K2/PPP2CA/PIK3CB/PPP2R2A/PTPN11/MAPK9/MAPK3/PAK6/PPP2R3B/PPP2R3A/PPP2R1B/NCK2/MAPK13/VAV3/VAV2/MAPK14/AKT3/CDC42/PLCG1	-1.13116496835209
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/2252	122/9376	0.819031534810587	GNAI1/HRAS/GNAS/PTK2/AKT1/MAP2K2/PIK3CB/MAPK9/MAPK3/GHR/MAP2K6/CRKL/GNAI3/MAPK13/ADCY5/CREB3L4/SOCS2/ADCY6/GNA11/MAPK14/AKT3/PLCB3/PLCG1/BCAR1	-1.13116496835209
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/2252	36/9376	0.693901716992303	AKR1B1/DCXR/UGP2/UGDH/RPE/XYLB	-1.03453831958085
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/2252	56/9376	0.743466125348896	CUL1/CSNK1E/CUL3/BTRC/KIF3A/GLI3/SMURF1/EVC2/BOC/EFCAB7	-1.0825267925346
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	19/2252	99/9376	0.799038340779016	CALM1/GNAS/PPP1CC/PPP1CA/CYP2J2/CAMK2G/CALM2/PIK3CB/MAPK9/MAP2K6/MAPK13/ADCY5/PPP1CB/ADCY6/PRKCH/MAPK14/PLCB3/F2RL1/PLCG1	-1.13014691192018
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/2252	99/9376	0.799038340779016	RAC3/HRAS/RPS6KB2/AKT1/MAP2K2/SLC44A2/PIK3CB/CHPT1/MAPK9/MAPK3/LYPLA1/WASF1/PIP5K1A/RPS6KB1/PDGFA/AKT3/PLCG1/SLC44A3/PIP5K1C	-1.13014691192018
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/2252	61/9376	0.750778906909705	MT1E/SLC39A4/MT1F/HMOX2/ATP7B/MT1G/FXYD2/MT1A/ATP1A4/ATP2B3/SLC6A19	-1.09790853260805
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/2252	90/9376	0.78642194592461	HRAS/RPS6KB2/AKT1/MAP2K2/PIK3CB/CSNK2A1/PTPN11/MAPK3/MAP2K6/CSNK2B/CSNK2A2/MAPK13/RPS6KB1/MAPK14/AKT3/BATF3/PLCG1	-1.14464658325991
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/2252	71/9376	0.762314562329573	CGA/HRAS/AKT1/MAP2K2/GALT/PIK3CB/ELF5/MAPK9/MAPK3/MAPK13/SOCS2/MAPK14/AKT3	-1.13026801029292
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/2252	71/9376	0.762314562329573	JAM3/ATP6V1C2/ATP6V1B1/CASP3/PTPN11/MAPK9/TJP1/MAPK13/ATP6V1E1/MAPK14/CDC42/MET/PLCG1	-1.13026801029292
NA	NA	hsa04517	IgSF CAM signaling	63/2252	299/9376	0.877240297736089	TUBB/TUBA1B/TUBB4B/CNTNAP2/ARPC1A/JAM3/TUBA1C/ARPC5L/DYNLL2/PARD3/CLMP/MYL6B/CDH1/CD2AP/EZR/PARD6B/PTK2/WASL/PAK4/AKT1/TUBB6/MAP2K2/MYH10/ROBO1/MYL12B/PIK3CB/DYNLL1/RDX/SPTBN1/TJP2/PTPN11/MAPK9/VCL/MAPK3/MPDZ/PAK6/ANK3/PXN/TJP1/ERC1/ACTR3B/ACTN4/NCK2/APP/MAPK13/MYL9/PRKCI/ARF6/RASA1/SSX2IP/GRIP1/LMO7/SRGAP1/ACTG1/VAV3/VAV2/MAPK14/AKT3/ICAM3/CDC42/PLCG1/BCAR1/CASKIN2	-1.21290874911482
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/2252	26/9376	0.640524661839049	PLA2G12A/PLA2G10/PLA2G2A/FADS2	-1.03194807529071
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/2252	62/9376	0.738669569701484	HDAC1/TLE1/SNW1/HDAC2/HEY1/DVL1/DVL3/KAT2A/DTX4/DVL2/TLE2	-1.16071497462405
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	27/2252	139/9376	0.808719986710454	KRT19/HSP90AB1/FKBP4/CALM1/KRT23/KRT18/GNAI1/HRAS/GNAS/KRT10/AKT1/MAP2K2/CALM2/PIK3CB/MAPK3/HSPA8/MMP2/GNAI3/KRT24/ADCY5/TFF1/KRT33B/CREB3L4/ADCY6/AKT3/PLCB3/GREB1	-1.27737789812188
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/2252	48/9376	0.693901716992303	AKT1/PIK3CB/SLC37A4/HK1/FXYD2/ATP1A4/AKT3/PLCB3	-1.19535009224998
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	25/2252	130/9376	0.800655827298811	GNAI1/HRAS/GNG12/GNAS/GNB5/AKT1/MAP2K2/PRKCZ/PIK3CB/RLN2/MAPK9/MAPK3/GNG4/NOS2/MMP2/GNAI3/MAPK13/ADCY5/GNB2/CREB3L4/COL4A2/ADCY6/MAPK14/AKT3/PLCB3	-1.28678548155096
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/2252	78/9376	0.747278772145557	CALM1/GNAI1/CFL2/CALM2/IRF3/CASP3/MAPK9/MAPK3/NOS2/GNAI3/C1R/MAPK13/MAPK14/C1S	-1.26009163702997
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	21/2252	112/9376	0.780639431616341	GNAI1/BAD/LAMA4/LAMB1/AKT1/LAMA1/CASP3/MAPK9/MAPK3/HSPA8/MAP2K6/LAMC1/NOS2/GNAI3/LAMA5/MAPK13/LDLR/CYCS/MAPK14/AKT3/LAMC2	-1.31303461926801
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/2252	49/9376	0.679740457461848	GXYLT1/B4GALT3/C1GALT1/B4GALT2/FUT10/C1GALT1C1/GALNT3/XXYLT1	-1.26367969282917
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/2252	28/9376	0.594772900279117	ATP6V1C2/CA2/ATP6V1B1/ATP6V1E1	-1.20733007997213
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	19/2252	104/9376	0.760623035933871	PCYT2/AGPAT5/PLA2G12A/CHPT1/LYPLA2/LYPLA1/GPD1L/GPAM/ETNK2/PTDSS2/CRLS1/PLA2G10/AGPAT1/PLA2G2A/CDS1/PISD/LCLAT1/ACHE/PEMT	-1.38013061163162
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/2252	75/9376	0.721657785671995	CGA/GPX3/GNAS/GPX8/TTF2/ADCY5/TTF1/FXYD2/ATP1A4/CREB3L4/HSPA5/ADCY6/PLCB3	-1.36066985502338
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/2252	17/9376	0.489812976700449	CDO1/GGT7	-1.1837146456341
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/2252	17/9376	0.489812976700449	MYH10/DAG1	-1.1837146456341
NA	NA	hsa04382	Cornified envelope formation	43/2252	217/9376	0.825007571354904	KRT19/S100A13/PKP3/KRT7/CLDN7/KRT23/KRT18/CLDN10/DSP/CLDN6/CLDN4/KRT8/PKP2/DSG2/JUP/PPP2R1A/BLMH/KRT10/CLDN3/PPP2CA/PPP2R2A/CAPN1/PPP2R3B/TJP1/KRT80/PPP2R3A/LAMA5/PPP2R1B/ITGB4/KRT24/KDSR/CASP14/KAZN/S100A16/ELOVL1/KRT33B/COL4A2/SPTLC1/PADI1/OCLN/S100A5/LAMC2/SPTLC3	-1.46633422682159
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	45/2252	227/9376	0.825345654572343	RAC3/CALM1/GNAI1/CDK4/HRAS/GNG12/GNAS/E2F1/HLA-G/PTK2/RPS6KB2/GNB5/AKT1/MAP2K2/CALM2/IRF3/PIK3CB/E2F2/CASP3/MAPK3/PXN/MAP2K6/FADD/CRKL/GNG4/GNAI3/TRAF2/MAPK13/ADCY5/TP53/E2F3/CDKN2A/GNB2/RPS6KB1/CREB3L4/MYC/ARHGEF12/ADCY6/GNA11/CYCS/MAPK14/AKT3/PLCB3/GNA12/BCAR1	-1.49766053607546
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/2252	120/9376	0.763291888691533	CALM1/MAGED1/BAD/HRAS/YWHAE/AKT1/MAP2K2/SH2B2/CAMK2G/CALM2/PIK3CB/PTPN11/MAPK9/MAPK3/CRKL/MAPK13/TP53/GAB1/MAPK14/AKT3/CDC42/PLCG1	-1.4672359725713
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/2252	101/9376	0.74199391519969	CDK4/HRAS/CDKN1B/AKT1/PRKCZ/PIK3CB/CASP3/MAPK9/MAPK3/MMP2/MAPK13/PLCD4/COL4A2/MAPK14/AKT3/PLCB3/CDC42/PLCG1	-1.46568806724947
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	26/2252	140/9376	0.773204770362852	RPS6/TFAM/CALM1/GNAI1/RRAS2/HRAS/GNG12/CDH1/MYL4/RPS6KB2/GNB5/AKT1/MAP2K2/CALM2/MAPK3/GNG4/NOS2/GNAI3/ADCY5/PRKAB1/GNB2/RPS6KB1/ADCY6/AKT3/PLCB3/SLC9A1	-1.52007090715791
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/2252	67/9376	0.683544974947642	CALM1/HRAS/PPP1CC/PPP1CA/MAP2K2/CAMK2G/CALM2/MAPK3/PPP1CB/PLCB3/GRIN2D	-1.46152335053809
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/2252	30/9376	0.555121373593843	CYP2J2/PLA2G12A/PLA2G10/PLA2G2A	-1.37213599124817
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/2252	52/9376	0.640524661839049	VDAC1/VDAC3/VDAC2/VAPB/LIPG/LDLR/VAPA/LDLRAP1	-1.46142831069228
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/2252	47/9376	0.620082385397377	PRKCZ/PIK3CB/PKM/MAPK9/MAPK3/HK1/SOCS2	-1.46800889842966
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/2252	103/9376	0.727586266360862	GNAI1/GNAS/PPP2R1A/AKT1/PPP2CA/PIK3CB/PPP2R2A/MAPK9/MAPK3/FADD/NOS2/GNAI3/PPP2R1B/MAPK13/GNA11/MAPK14/AKT3/PLCB3	-1.56295097933605
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/2252	103/9376	0.727586266360862	GNAS/SERPINB9/LAMA4/PTK2/LAMB1/ARG2/PIK3CB/LAMA1/CASP3/VCL/LAMC1/NOS2/ACTN4/LAMA5/COL4A2/GNA11/PLCB3/LAMC2	-1.56295097933605
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/2252	63/9376	0.660858778087908	PTGES3/PTGDS/PTGES2/CYP2J2/PTGR1/PLA2G12A/PTGES/CBR1/PLA2G10/PLA2G2A	-1.51849697019834
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/2252	31/9376	0.53721423251017	ALDH7A1/ALDH9A1/UGDH/ALDH1B1	-1.45103892948461
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/2252	157/9376	0.769037571698476	SLC2A1/UQCRFS1/SLC16A1/PPARG/PTK2/MAP2K2/CAMK2G/ARG2/DOCK1/CASP3/PTPN11/DUSP5/MAPK3/TYRO3/PBX1/CPT1C/XKR8/PPARD/CRKL/BSG/MAPK13/TMEM30B/ARNT/EPO/MAPK14/MFGE8/RAB17/BCAR1/ANO7	-1.64080560762214
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/2252	59/9376	0.635096486738718	CGA/GNAI1/GNAS/AKT1/PIK3CB/GNAI3/ADCY5/ADCY6/AKT3	-1.58078890359059
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/2252	43/9376	0.580940972365649	ACAT2/GOT2/PLA2G12A/PLA2G10/AGPAT1/PLA2G2A	-1.54848381965902
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	45/2252	233/9376	0.804092118403098	LMNB1/DIAPH3/LMNB2/CSRP2/ENO1/PDLIM1/TPM2/DSP/TPM1/DSC2/SYNE2/PKP2/FHL2/DSG2/JUP/MYL4/SGCB/COL9A3/TNNI2/MYH10/SGCE/DAG1/TPM4/SPTBN1/NID1/TMOD3/CSRP1/LAMA1/EMD/VCL/SSPN/LBR/ANK3/PDLIM2/ITGB4/MYL9/TNNC1/ACTG1/ATP1A4/TNNT3/COL27A1/COL4A2/SNTB2/DMD/NEBL	-1.70252455774957
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	24/2252	134/9376	0.745685427215609	CALM1/CALD1/GNAS/PPP1R14A/PPP1CC/MYL6B/PPP1CA/MAP2K2/MYH10/RAMP1/PLA2G12A/CALM2/MAPK3/ADCY5/MYL9/PPP1CB/ARHGEF12/ADCY6/PRKCH/PLA2G10/PLA2G2A/GNA11/PLCB3/GNA12	-1.66704967004402
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/2252	105/9376	0.71372748033494	TPM2/TPM1/GNAS/SGCB/SGCE/DAG1/TPM4/LAMA1/EMD/SSPN/ITGB4/ADCY5/TNNC1/ACTG1/CACNB3/SNTB2/ADCY6/DMD	-1.65851305879099
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/2252	49/9376	0.594772900279117	GNAI1/GNAS/GNAI3/ADCY5/SLC18A2/CREB3L4/GRIN2D	-1.59894457115306
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/2252	65/9376	0.640524661839049	AKR1B1/ALDH7A1/LIPG/AGPAT5/ALDH9A1/ALDH1B1/GPAM/AGPAT1/AGK/LCLAT1	-1.63506676812144
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/2252	65/9376	0.640524661839049	CYP11A1/GNAS/HSD3B1/PBX1/ADCY5/LDLR/CREB3L4/ADCY6/GNA11/PLCB3	-1.63506676812144
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/2252	38/9376	0.547817144993923	SFN/PIK3CB/MAPK3/FXYD2/ATP1A4	-1.57031518730865
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/2252	136/9376	0.734719465050674	CCNE1/CDK2/CCNE2/CDK4/CCND3/BAD/EIF2S1/EIF3H/CDKN1B/AKT1/IRF3/PIK3CB/CSNK2A1/CASP3/MAPK9/HSPA8/FADD/CSNK2B/CSNK2A2/TP53/RCHY1/CYCS/AKT3/MAVS	-1.75205094082218
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/2252	97/9376	0.686748091043929	CALM1/GNAI1/GNG12/GNAS/GNB5/CAMK2G/CALM2/MAPK3/GNG4/GNAI3/ADCY5/GNB2/ADCY6/PLCB3/GRIN2D/PER2	-1.74355993923905
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	33/2252	180/9376	0.763291888691533	SRSF3/ALYREF/SRPK1/SRSF2/SRSF7/SRSF9/SRSF4/BAD/EIF2S1/PPP1CC/SRSF1/HLA-G/PPP1CA/AKT1/EIF2B3/IRF3/PIK3CB/EIF2B2/EIF2B1/CASP3/PTPN11/FADD/SRSF6/TRAF2/TP53/EIF2B5/DAXX/PPP1CB/EIF2B4/CYCS/AKT3/POU2F1/MAVS	-1.80284249929715
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/2252	166/9376	0.752423548545871	CALM1/GNAI1/SLC25A6/SLC25A4/VDAC1/BAD/VDAC3/PPP1CC/VDAC2/PPP1CA/AKT1/MAP2K2/CALM2/MAPK3/ADRA2C/SLC25A5/GNAI3/ADCY5/MYL9/FXYD2/PPP1CB/ATP1A4/CREB3L4/ADCY6/GNA11/SRF/AKT3/PLCB3/GNA12/ATP2B3	-1.80942855053255
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	11/2252	72/9376	0.636076573909611	PIN1/IRF3/MAPK9/ATG12/FADD/SIKE1/TRAF2/MAPK13/ATG5/MAPK14/MAVS	-1.74280696011675
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/2252	99/9376	0.672874392234961	TPM2/TPM1/SGCB/SGCE/DAG1/TPM4/LAMA1/EMD/SSPN/ITGB4/PRKAB1/TNNC1/ACTG1/CACNB3/SNTB2/DMD	-1.83965437416664
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/2252	94/9376	0.664373984354333	HSP90AB1/TRAF4/SRSF1/ANAPC5/ELAVL1/CASP3/MAPK9/MAPK3/FADD/IL17D/TRAF2/MAPK13/TRAF3IP2/USP25/MAPK14	-1.83868205678399
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/2252	115/9376	0.687867789018457	NACA/GNAI1/GNAS/GCM1/GATA3/PDE4D/MAPK3/WNK2/GNAI3/ADCY5/LRP5/MMP15/CREB3L4/LRP6/ADCY6/GNA11/PLCB3/GNA12/PDE4C	-1.89350494070919
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/2252	15/9376	0.277560686796921	ST8SIA1	-1.57432268674122
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/2252	91/9376	0.640524661839049	GNAI1/GNG12/GNAS/GNB5/PDE4D/GNG4/GNAI3/ADCY5/GNB2/ADCY6/GRK5/GRK6/PDE4C/GABRE	-1.9373438968823
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/2252	70/9376	0.594772900279117	LEP/SLC2A1/AKT1/PTPN11/MAPK9/CPT1C/TRAF2/PRKAB1/AKT3/STK11	-1.91325938830026
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/2252	36/9376	0.462601144661535	C1GALT1/C1GALT1C1/ST6GALNAC2/GALNT3	-1.81627842954136
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/2252	23/9376	0.362035678430767	THOP1/MME	-1.72223621791161
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/2252	65/9376	0.576472195655144	CGA/HRAS/AKT1/MAP2K2/PIK3CB/MAPK3/GNA11/AKT3/PLCB3	-1.92640819757614
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	35/2252	196/9376	0.743466125348896	RPS27A/CALM1/UBA52/CDK4/HRAS/GNG12/E2F1/HLA-G/GNB5/AKT1/MAP2K2/CALM2/IRF3/PIK3CB/UBB/E2F2/CASP3/MAPK9/MAPK3/TCF7L2/MAP2K6/FADD/GNG4/TRAF2/MAPK13/TP53/E2F3/GNB2/MYC/CYCS/MAPK14/AKT3/TCF7/PLCG1/ATG14	-2.04060662220405
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/2252	82/9376	0.609279556383486	HSP90AB1/NFYB/HSPA2/HLA-G/HSPA4/PSME3/RFXANK/HSPA8/PSME1/NFYC/HSPA5/RFXAP	-1.9979269419669
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/2252	98/9376	0.637256678870482	CALM1/CYP11A1/GNAS/HSD3B1/CAMK2G/CALM2/ADCY5/LDLR/ATP1A4/CREB3L4/ATF1/ADCY6/GNA11/PLCB3/ATP2B3	-2.02951915464754
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2252	66/9376	0.567737768448248	CYP11A1/HSD3B1/COMT/DHRS11/LRTOMT/HSD17B7/HSD17B8/STS/HSD17B6	-1.98130937431764
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/2252	50/9376	0.499609236234458	HBA2/HBA1/GYPA/GYPB/HBB/MET	-1.99459376613906
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/2252	115/9376	0.65166422117538	GNAI1/HRAS/GNG12/GNB5/AKT1/CAMK2G/PIK3CB/MAPK3/GNG4/GNAI3/ADCY5/GNB2/CREB3L4/ADCY6/GNA11/AKT3/PLCB3/ACHE	-2.11312865197755
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/2252	38/9376	0.438253715995139	UNG/RFXANK/RFXAP/ADA	-1.95080090149631
Organismal Systems	Immune system	hsa04611	Platelet activation	20/2252	126/9376	0.660858778087908	GNAI1/GNAS/PPP1CC/PPP1CA/AKT1/PRKCZ/MYL12B/PIK3CB/MAPK3/GNAI3/MAPK13/ADCY5/PRKCI/PPP1CB/ACTG1/ARHGEF12/ADCY6/MAPK14/AKT3/PLCB3	-2.15477963660148
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	69/2252	362/9376	0.793578206726004	CCNE1/RPS6/HSP90AB1/CDK2/YWHAQ/PGF/CCNE2/CDK4/CCND3/BAD/HRAS/GNG12/THEM4/YWHAE/BRCA1/EIF4B/LAMA4/COL9A3/PPP2R1A/CDKN1B/EFNA1/PTK2/EFNA4/RPS6KB2/LAMB1/GNB5/AKT1/ERBB3/EIF4E2/MAP2K2/PPP2CA/PIK3CB/PPP2R2A/ERBB2/LAMA1/PHLPP1/MAPK3/GYS1/PPP2R3B/GHR/MLST8/GNG4/LAMC1/PPP2R3A/FGFR4/LAMA5/PPP2R1B/PKN3/ANGPT1/ITGB4/CDC37/TP53/YWHAB/GNB2/RPS6KB1/CREB3L4/EPO/FLT4/MYC/COL4A2/PDGFA/SGK2/AKT3/MET/YWHAZ/STK11/EFNA3/TCL1B/LAMC2	-2.2519509710562
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/2252	51/9376	0.489812976700449	PAFAH1B3/PLA2G12A/CHPT1/PAFAH1B1/PLA2G10/PLA2G2A	-2.05398823535815
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/2252	45/9376	0.462601144661535	ABCG2/ABCA7/ABCD3/ABCB10/DEFB1	-2.03164009476392
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/2252	76/9376	0.547817144993923	PPARG/SLC27A6/FABP7/HMGCS1/SLC27A2/CPT1C/PPARD/FADS2/CPT2/EHHADH	-2.22529344860123
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	34/2252	201/9376	0.704258459036964	CCNA2/TAF15/HDAC1/MYCN/JUP/PPARG/CDKN1B/FUS/PTK2/HDAC2/TCF3/PBX1/FUT8/GADD45A/EWSR1/ETV4/ETV5/PRCC/SS18/SIX4/MEN1/TP53/SPINT1/ETV7/ASPSCR1/MYC/ATF1/PDGFA/TLX3/CDKN2C/MET/MLLT1/PER2/MEIS1	-2.38295147970318
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	37/2252	216/9376	0.713176764686534	HSPD1/HSP90AB1/CALM1/HSPA2/BAD/HRAS/EIF2S1/PPARG/PTK2/CYP2J2/AKT1/CAMK2G/CASP6/HSPA4/CALM2/IRF3/PIK3CB/CASP3/MAPK9/MAPK3/HSPA8/MAP2K6/TRAF2/MAPK13/VLDLR/TP53/LDLR/HSPA5/VAV3/VAV2/CYCS/MAPK14/AKT3/PLCB3/CDC42/POU2F1/PLCG1	-2.39773589509836
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/2252	105/9376	0.594772900279117	CALM1/RRAS2/HRAS/AKT1/CALM2/PIK3CB/PTPN11/MAPK9/MAPK3/IL17D/MAPK13/KSR1/ARHGEF12/MAPK14/AKT3	-2.34767359944089
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/2252	193/9376	0.690306371308405	RAC3/GNAI1/CCR7/BAD/HRAS/GNG12/PARD3/PTK2/GNB5/AKT1/PRKCZ/PIK3CB/MAPK3/PXN/CRKL/GNG4/GNAI3/ADCY5/GNB2/ADCY6/VAV3/VAV2/CCL21/GSK3A/AKT3/GRK5/PLCB3/CDC42/PLCG1/GRK6/BCAR1/CCL28	-2.44414242201596
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	28/2252	173/9376	0.67384675407345	KPNA2/FDPS/SLC25A6/SLC25A4/VDAC1/CDK4/CCND3/EIF2S1/RAB11A/CPSF4/RAE1/AKT1/MAP2K2/XPO1/NXT1/IRF3/PIK3CB/CASP3/MAPK3/RAB11B/SLC25A5/FADD/PABPN1/NUP98/ACTG1/CYCS/AKT3/MAVS	-2.43437747833596
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/2252	168/9376	0.669119512814007	HMGB1/PARP1/HSP90AB1/PYGL/SLC25A6/SLC25A4/PPIA/VDAC1/VDAC3/VDAC2/PPID/CAMK2G/PGAM5/CAPN1/MAPK9/DNM1L/CHMP4C/SLC25A5/FADD/AIFM1/CHMP2A/TRAF2/CHMP2B/RBCK1/VPS4A/VPS4B/GLUD2	-2.43304991067321
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/2252	55/9376	0.454190214758598	SMPD4/CERS5/KDSR/SMPD2/SPTLC1/SPTLC3	-2.28243954953908
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	41/2252	238/9376	0.717226144454229	RAC3/CALM1/PGF/RRAS2/BAD/HRAS/GNG12/RALBP1/EFNA1/EFNA4/FOXO4/PAK4/GNB5/AKT1/MAP2K2/PLA2G12A/CALM2/PIK3CB/PTPN11/MAPK9/MAPK3/PAK6/GNG4/FGFR4/ANGPT1/ARF6/RASA1/NF1/GAB1/KSR1/GNB2/FLT4/PLA2G10/PDGFA/PLA2G2A/RASGRF1/AKT3/CDC42/MET/PLCG1/EFNA3	-2.4843342738735
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/2252	29/9376	0.287131744962332	CALM1/CALM2	-2.16162337964246
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/2252	102/9376	0.571448472817191	RAB11A/GNAS/CA2/PLA2G12A/RAB8A/ADCY5/FXYD2/ATP1A4/ADCY6/PLA2G10/PLA2G2A/PLCB3/ATP2B3/SLC9A1	-2.44668164034571
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/2252	86/9376	0.532529224668512	SLC2A1/GNAS/CAMK2G/ADCY5/FXYD2/ATP1A4/CREB3L4/ADCY6/GNA11/PLCB3/TRPM4	-2.44852030559162
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/2252	69/9376	0.482714237907689	CALM1/GNAI1/GNAS/CALM2/GNAI3/ADCY5/ADCY6/PLCB3	-2.4247004286872
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/2252	89/9376	0.514578801365079	HMMR/LAMA4/COL9A3/LAMB1/DAG1/LAMA1/LAMC1/LAMA5/ITGB4/COL4A2/LAMC2	-2.58692533891807
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/2252	89/9376	0.514578801365079	GNAI1/GNG12/SLC38A1/GNB5/SLC6A11/GNG4/GNAI3/ADCY5/GNB2/ADCY6/GABRE	-2.58692533891807
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/2252	90/9376	0.508861259127689	ABCG2/SLC2A1/GNAS/CA2/HMGCR/ADCY5/LDLR/FXYD2/ATP1A4/ADCY6/SLC9A1	-2.63220059794919
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/2252	79/9376	0.474312566045372	GSTP1/GSTA4/ADH5/AKR7A2/MGST3/GSTO2/CBR1/ALDH3B2/GSTM3	-2.63801707229196
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/2252	115/9376	0.54305351764615	GNAI1/HRAS/GNG12/GNAS/CYP2J2/GNB5/CASP3/MAPK3/GNG4/GNAI3/APP/ADCY5/SLC18A2/GNB2/PLCB3	-2.77199978578264
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	22/2252	154/9376	0.594772900279117	CALM1/GNAI1/HRAS/GNAS/PPP1CC/MYL6B/EEF2/PPP1CA/MAP2K2/CAMK2G/CALM2/MAPK3/GNAI3/ADCY5/MYL9/PPP1CB/PRKAB1/ACTG1/CACNB3/ADCY6/EEF2K/PLCB3	-2.85071734807418
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/2252	149/9376	0.58678937141631	RRAS2/HRAS/GNAS/AKT1/MAP2K2/AGPAT5/PIK3CB/PTPN11/MAPK3/ADCY5/ARF6/GAB1/PIP5K1A/ADCY6/PDGFA/AGPAT1/AKT3/PLCB3/PLCG1/GNA12/PIP5K1C	-2.85852657231475
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/2252	105/9376	0.515469846908568	PARP1/CSNK2A1/UBE2I/GADD45A/ERC1/CSNK2B/EDARADD/CSNK2A2/TRAF2/PPP1R13L/CARD10/CCL21/PLCG1	-2.80711395987416
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/2252	144/9376	0.578251430826919	ALDH7A1/ADH5/FASN/AKT1/TRA2B/IRF3/CASP3/MAPK9/ALDH9A1/CPT1C/ACACA/TCF7L2/MAP2K6/FADD/ALDH1B1/MAPK13/PRKAB1/MAPK14/AKT3/TCF7	-2.86744331891776
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2252	26/9376	0.160131165459762	MNX1	-2.41101665481261
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/2252	79/9376	0.421611169818108	ATP6V1C2/ATP6V1B1/CLTA/SLC6A11/AP2A1/ATP6V1E1/AP2M1/SLC18A2	-2.90248446108852
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/2252	73/9376	0.399231124844887	GSTP1/GSTA4/ADH5/MGST3/GSTO2/ALDH3B2/GSTM3	-2.89711156621382
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/2252	187/9376	0.601134107768733	HSP90AB1/TXN2/VDAC1/TRIP6/VDAC3/YWHAE/VDAC2/SUGT1/BRCC3/IRF3/MAPK9/DNM1L/MAPK3/GSDMD/ATG12/FADD/TXN/TRAF2/MAPK13/ATG5/DHX33/RBCK1/MFN1/MAPK14/PLCB3/MAVS/TP53BP1	-3.09757231419366
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	49/2252	300/9376	0.680023682652457	STMN1/RAC3/DUSP9/PGF/RRAS2/HRAS/GNG12/PPP5C/EFNA1/EFNA4/AKT1/ERBB3/MAP2K2/MAP3K4/ECSIT/ERBB2/CASP3/MAPK9/DUSP5/MAPK3/HSPA8/GADD45A/MAP2K6/STK3/CRKL/FGFR4/ANGPT1/MAP3K13/TRAF2/MAPK13/TP53/RASA1/NF1/DAXX/FLT4/MYC/CACNB3/PDGFA/CDC25B/RASGRF1/SRF/MAPK14/AKT3/MAPT/CDC42/MET/GNA12/EFNA3/MAP4K2	-3.16693460355039
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/2252	116/9376	0.502480553684082	GNAI1/GNG12/GNAS/SLC38A1/GNB5/HOMER1/MAPK3/GNG4/GNAI3/ADCY5/GNB2/ADCY6/PLCB3/GRIN2D	-3.03138737572085
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/2252	93/9376	0.447678527091808	CALM1/GNAS/CALM2/ADCY5/FXYD2/ATP1A4/ADCY6/PLCB3/ATP2B3/SLC9A1	-3.00951909217989
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/2252	119/9376	0.489812976700449	AKT1/PIK3CB/PGAM5/CASP3/MAPK9/DNM1L/MAPK3/MAP2K6/FADD/TRAF2/MAPK13/CREB3L4/MAPK14/AKT3	-3.14902155061217
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/2252	70/9376	0.35686374016747	GSTP1/GSTA4/MGST3/GSTO2/CBR1/GSTM3	-3.0365355326148
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/2252	41/9376	0.203093185461162	GRIN2D/GABRE	-2.87508165591519
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/2252	103/9376	0.444636051664971	COL9A3/COL21A1/SLC1A5/MME/KCNK5/FXYD2/ATP1A4/COL27A1/COL4A2/COL16A1/SLC6A19	-3.18635413619785
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/2252	91/9376	0.411765854039389	RAC3/HRAS/AKT1/MAP2K2/PIK3CB/MAPK3/VAV3/VAV2/AKT3	-3.17020866701101
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	33/2252	226/9376	0.607931592763168	CGA/RAC3/CALM1/GNAI1/RRAS2/BAD/GNAS/PPP1CC/PPP1CA/AKT1/MAP2K2/CAMK2G/CALM2/PIK3CB/PDE4D/MAPK9/MAPK3/GNAI3/ADCY5/MYL9/FXYD2/PPP1CB/ATP1A4/GLI3/CREB3L4/ADCY6/VAV3/VAV2/AKT3/GRIN2D/ATP2B3/SLC9A1/PDE4C	-3.3543887805974
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	31/2252	217/9376	0.594772900279117	BIRC5/CDC6/KPNA2/HSP90AB1/PTGES3/GSTA4/GNAI1/CDC25A/CCND3/BAD/HRAS/GNAS/E2F1/MGST3/RPS6KB2/AKT1/KLF5/MAP2K2/KPNB1/PIK3CB/GSTO2/MAPK3/GNAI3/ADCY5/ARNT/RPS6KB1/CREB3L4/MYC/ADCY6/AKT3/GSTM3	-3.39556614281569
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/2252	44/9376	0.189245922816083	HSPD1/HLA-G	-3.03065144065755
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/2252	68/9376	0.306133110437781	ADH5/RDH13/HSD17B6/ALDH1A3/PNPLA4	-3.22857075813657
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/2252	109/9376	0.420160672674239	AKT1/MAP2K2/IRF3/PIK3CB/MAPK9/MAPK3/MAP2K6/FADD/MAPK13/MAPK14/AKT3	-3.42341233526733
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/2252	191/9376	0.544948992402332	CALM1/GNAI1/HDAC1/HAT1/SLC29A1/HRAS/GNG12/GNAS/PPP1CC/PPP1CA/GNB5/HDAC2/SLC29A2/CALM2/MAPK3/PKIA/GNG4/GNAI3/ADCY5/HDAC3/SLC18A2/PPP1CB/GNB2/CREB3L4/GRIN2D	-3.57227644179198
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/2252	181/9376	0.529052137817336	HSPD1/NFYB/CALM1/BAD/HSPA9/AKT1/CAMK2G/CALM2/CASP3/MAPK9/MAPK3/RFXANK/FADD/NOS2/MAPK13/CEBPG/KSR1/NFYC/ARHGEF12/RFXAP/CYCS/MAPK14/AKT3	-3.5970305499857
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/2252	78/9376	0.320262330919525	EEF1A1/MARCKSL1/MAPK3/NOS2/MAPK13/MAPK14	-3.38923548074831
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/2252	99/9376	0.378491845632165	KRT19/KRT23/KRT18/KRT10/KRT24/C1R/KRT33B/DEFB1/C1S	-3.49517178607507
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	49/2252	323/9376	0.631600943640053	STMN1/CCNE1/CDCA5/EZH2/KIF23/IGF2BP1/DNMT1/HDAC1/CCNE2/CDC25A/TPM1/HRAS/BRCA1/CCNG1/DNMT3B/CDC25C/E2F1/TRIM71/EZR/CDKN1B/EFNA1/HNRNPK/EFNA4/PAK4/ERBB3/FZD3/HDAC2/MAP2K2/PIK3CB/RDX/E2F2/ERBB2/CASP3/MAPK3/UBE2I/CRKL/FSCN1/TP53/E2F3/CDKN2A/PDCD4/MYC/PDGFA/SLC7A1/CDC25B/TP63/MET/PLCG1/EFNA3	-3.78818679594156
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/2252	39/9376	0.106754110306508	HLA-G	-3.14273329396025
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/2252	54/9376	0.154200381553845	CGA/HLA-G	-3.50443243614154
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/2252	250/9376	0.549570159857904	AP1M2/LAPTM4B/CTSV/ATP6V1C2/SLC29A1/AP1S1/BLOC1S4/RRAGA/ATP6V1B1/SLC29A2/SLC38A9/CLTA/PPT2/VPS26A/MLST8/BLOC1S5/SNAP29/AP2A1/TELO2/CTSE/AP1S3/ATP6V1E1/AKT1S1/STX17/TTI1/VPS29/AP2M1/KXD1/LAMTOR5/AP4M1/AP3M1/AP3M2/AP5S1	-4.05849300719898
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/2252	45/9376	0.0925202289323071	HLA-G	-3.43073355994985
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/2252	195/9376	0.469718085348636	HMGB1/SLC25A6/SLC25A4/HDAC1/HAT1/VDAC1/VDAC3/VDAC2/AKT1/HDAC2/MAP2K2/PIK3CB/MAPK3/GSDMD/SLC25A5/MAPK13/HDAC3/ACTG1/MAPK14/AKT3/PLCB3/PLCG1	-4.20714038164512
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/2252	93/9376	0.268607116255085	GATA3/MAPK9/MAPK3/MAPK13/MAPK14/PLCG1	-3.98525307358584
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/2252	109/9376	0.305571398308537	HSP90AB1/GATA3/MAPK9/MAPK3/MAPK13/MAPK14/PLCG1/RORA	-4.09995550311714
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/2252	50/9376	0.0832682060390764	CCL28	-3.65415921688091
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/2252	88/9376	0.236557403520103	TFPI/PROCR/C1R/CD55/C1S	-4.04542819008613
NA	NA	hsa04081	Hormone signaling	25/2252	219/9376	0.475275148624865	CGA/GNAI1/LEP/GAST/GNG12/GNAS/GNB5/RAMP1/PIK3CB/ADRA2C/GHR/GNG4/GNAI3/ADCY5/THRB/OPRK1/GNB2/EPO/ADCY6/SMAD5/GNA11/PLCB3/STK11/GNA12/SLC16A2	-4.41758545556677
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/2252	133/9376	0.344342205424752	RAC3/HRAS/HLA-G/MAP2K2/PIK3CB/CASP3/PTPN11/MAPK3/VAV3/VAV2/PLCG1	-4.28158379868334
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/2252	155/9376	0.376049962757119	TUBB/TUBA1B/TUBB4B/TUBA1C/ATP6V1C2/HLA-G/TUBB6/ATP6V1B1/DYNC1LI2/C1R/ATP6V1E1/ACTG1/DYNC1I2/STX18	-4.40387039145857
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/2252	66/9376	0.126163948544055	GATA3/RORA	-4.00529917719423
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/2252	168/9376	0.371733062674448	LEP/CCND3/HRAS/AKT1/PIK3CB/PTPN11/GHR/IL20RA/LIFR/EPO/STAM/SOCS2/MYC/PDGFA/AKT3	-4.61980949296539
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	29/2252	254/9376	0.475349995104964	CALM1/SLC25A6/SLC25A4/VDAC1/VDAC3/GNAS/VDAC2/ERBB3/CAMK2G/CALM2/ERBB2/SLC25A5/NOS2/FGFR4/PHKG2/ITPKA/TNNC1/PLCD4/FLT4/PDGFA/PHKA2/MST1/GNA11/PLCB3/MET/PLCG1/GRIN2D/ATP2B3/CASQ1	-4.76594889918905
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/2252	142/9376	0.322517699447127	FHL2/PPARG/AKT1/PIK3CB/MAPK9/MAPK3/MAP2K6/TRAF2/MAPK13/MAPK14/AKT3	-4.57356722080208
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/2252	160/9376	0.338277087033748	CNTNAP2/JAM3/CLDN7/CLDN10/CLDN6/CLDN4/CDH1/CDH5/HLA-G/CLDN3/CDH3/ICAM3/OCLN	-4.74649258841119
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/2252	95/9376	0.175301486398056	ATP6V1C2/ATP6V1B1/ANGPT1/ATP6V1E1	-4.54221308461208
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/2252	86/9376	0.145235243091412	KCNK5/ADCY6/PLCB3	-4.47709027866108
NA	NA	hsa04082	Neuroactive ligand signaling	18/2252	199/9376	0.376589876558637	GNAI1/GNG12/GNAS/GNB5/ADRA2C/SLC6A11/GNG4/GNAI3/ADCY5/SLC18A2/OPRK1/GNB2/ADCY6/GNA11/PLCB3/GRIN2D/ACHE/GABRE	-4.99755863952033
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/2252	100/9376	0.166536412078153	CCR7/IL20RA/CCL21/CCL28	-4.71101120479979
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/2252	100/9376	0.166536412078153	GYPA/MME/CD55/EPO	-4.71101120479979
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/2252	143/9376	0.203803301494243	SNRPD1/SNRPB/SNRPD3/SSB/ACTN4/C1R/C1S	-5.39417273149371
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/2252	298/9376	0.223538808158594	BMP7/CCR7/LEP/BMP4/ACVR2B/GHR/GDF11/IL17D/IL36RN/IL20RA/LIFR/EPO/RELL1/CCL21/ACVRL1/CCL28	-7.65844632568933
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/2252	370/9376	0.202544284959916	TMEM97/CGA/LEP/CHRNA5/VGF/GAL/GZMA/PGRMC2/RLN2/NPFFR2/ADRA2C/GHR/PGRMC1/THRB/OPRK1/F2RL1/GRIN2D/GABRE	-8.79932465366441
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/2252	449/9376	0.037090514939455	CALM1/CAMK2G/CALM2/NCALD	-11.7561127793678