ID	Description	GeneRatio	BgRatio	RichFactor	FoldEnrichment	pvalue	p.adjust
GO:0003735	structural constituent of ribosome	148/4565	175/18639	0.845714285714286	3.4530708809263	1.62595384535492e-63	2.14300716817778e-60
GO:0140098	catalytic activity, acting on RNA	199/4565	387/18639	0.51421188630491	2.09953895921954	9.40343040353758e-31	6.19686063593126e-28
GO:0140097	catalytic activity, acting on DNA	175/4565	336/18639	0.520833333333333	2.12657447973713	4.93927464506819e-28	2.16998799406662e-25
GO:0140104	molecular carrier activity	137/4565	249/18639	0.550200803212851	2.24648253473918	3.23953844581141e-25	1.06742791789486e-22
GO:0008094	ATP-dependent activity, acting on DNA	117/4565	210/18639	0.557142857142857	2.27482710061023	2.42908590377655e-22	6.40307044235499e-20
GO:0003697	single-stranded DNA binding	78/4565	121/18639	0.644628099173554	2.63203135607796	1.27910270888495e-20	2.8097622838506e-18
GO:0019843	rRNA binding	50/4565	65/18639	0.769230769230769	3.14078692391945	8.10210732563608e-19	1.52551106502691e-16
GO:0140597	protein carrier chaperone	102/4565	188/18639	0.542553191489362	2.21525716016872	1.54320772854356e-18	2.54243473277551e-16
GO:0004386	helicase activity	88/4565	155/18639	0.567741935483871	2.318103381267	7.44191366929848e-18	1.08982691290393e-15
GO:0043021	ribonucleoprotein complex binding	96/4565	177/18639	0.542372881355932	2.2145209497466	1.61675622012494e-17	2.13088469812467e-15
GO:0003689	DNA clamp loader activity	89/4565	160/18639	0.55625	2.27118154435926	2.86266262759471e-17	3.42999031197257e-15
GO:0140713	histone chaperone activity	89/4565	164/18639	0.542682926829268	2.21578687254561	2.29902585497425e-16	2.52509673071338e-14
GO:0180051	translation factor activity	56/4565	84/18639	0.666666666666667	2.72201533406353	3.54457692378554e-16	3.5936556811918e-14
GO:0045296	cadherin binding	149/4565	334/18639	0.446107784431138	1.82146834479999	4.6172537776096e-16	4.34681462777818e-14
GO:0016887	ATP hydrolysis activity	176/4565	417/18639	0.422062350119904	1.7232902834359	7.56747866272866e-16	6.64929125165092e-14
GO:0008135	translation factor activity, RNA binding	55/4565	83/18639	0.662650602409639	2.7056176513282	9.75474644456384e-16	8.03547238370946e-14
GO:0140101	catalytic activity, acting on a tRNA	78/4565	139/18639	0.561151079136691	2.29119276320455	1.33891667112539e-15	1.0380542191431e-13
GO:0140658	ATP-dependent chromatin remodeler activity	85/4565	158/18639	0.537974683544304	2.19656300691835	2.14272575607869e-15	1.56895141472873e-13
GO:0015616	DNA translocase activity	82/4565	152/18639	0.539473684210526	2.2026834611172	5.39758980395129e-15	3.74422282189884e-13
GO:0003743	translation initiation factor activity	39/4565	51/18639	0.764705882352941	3.12231170671993	8.10886579546849e-15	5.34374255921374e-13
GO:0000510	H3-H4 histone complex chaperone activity	81/4565	151/18639	0.536423841059603	2.19023088138224	1.20596578738147e-14	6.62276211570323e-13
GO:0140584	chromatin extrusion motor activity	81/4565	151/18639	0.536423841059603	2.19023088138224	1.20596578738147e-14	6.62276211570323e-13
GO:0140665	ATP-dependent H3-H4 histone complex chaperone activity	81/4565	151/18639	0.536423841059603	2.19023088138224	1.20596578738147e-14	6.62276211570323e-13
GO:0140849	ATP-dependent H2AZ histone chaperone activity	81/4565	151/18639	0.536423841059603	2.19023088138224	1.20596578738147e-14	6.62276211570323e-13
GO:0140674	ATP-dependent histone chaperone activity	81/4565	152/18639	0.532894736842105	2.17582146768894	1.96600453901377e-14	1.03647759296806e-12
GO:0061775	cohesin loader activity	81/4565	153/18639	0.529411764705882	2.16160041234457	3.18135484609456e-14	1.6127021873664e-12
GO:0042393	histone binding	114/4565	247/18639	0.461538461538462	1.88447215435167	7.65136009322935e-14	3.72326565783811e-12
GO:0003712	transcription coregulator activity	195/4565	495/18639	0.393939393939394	1.60846360649208	7.90982082090039e-14	3.72326565783811e-12
GO:0016741	transferase activity, transferring one-carbon groups	101/4565	215/18639	0.469767441860465	1.91807127028197	5.16840079278074e-13	2.34894904996035e-11
GO:0030515	snoRNA binding	27/4565	32/18639	0.84375	3.44505065717415	1.58735796999271e-12	6.97379268150131e-11
GO:0003678	DNA helicase activity	46/4565	74/18639	0.621621621621622	2.53809537905923	6.56409058172104e-12	2.70358480834636e-10
GO:0003684	damaged DNA binding	46/4565	74/18639	0.621621621621622	2.53809537905923	6.56409058172104e-12	2.70358480834636e-10
GO:0008168	methyltransferase activity	93/4565	204/18639	0.455882352941176	1.86137813285226	3.45216081492356e-11	1.37877210729371e-09
GO:0008186	ATP-dependent activity, acting on RNA	47/4565	79/18639	0.594936708860759	2.42914026647441	3.59027659521394e-11	1.39176016249764e-09
GO:0016853	isomerase activity	84/4565	180/18639	0.466666666666667	1.90541073384447	7.00448613291022e-11	2.63768934947876e-09
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	79/4565	167/18639	0.473053892215569	1.93148992267382	1.12197124794516e-10	4.10766140219923e-09
GO:0003688	DNA replication origin binding	16/4565	16/18639	1	4.08302300109529	1.64307868588858e-10	5.85291272432744e-09
GO:0003724	RNA helicase activity	45/4565	77/18639	0.584415584415584	2.38618227336738	2.14952499866329e-10	7.45545775852163e-09
GO:0043022	ribosome binding	58/4565	112/18639	0.517857142857143	2.1144226255672	4.24174446533072e-10	1.43349210392459e-08
GO:0008137	NADH dehydrogenase (ubiquinone) activity	29/4565	41/18639	0.707317073170732	2.8879918788235	5.65402412358406e-10	1.86300094872095e-08
GO:0003713	transcription coactivator activity	107/4565	256/18639	0.41796875	1.70657601998905	6.88487380599344e-10	2.21323504299984e-08
GO:0009055	electron transfer activity	59/4565	116/18639	0.508620689655172	2.07670997469502	7.53548691254899e-10	2.3647075596999e-08
GO:0051540	metal cluster binding	44/4565	77/18639	0.571428571428571	2.33315600062588	9.24436537561217e-10	2.83350548024578e-08
GO:0003954	NADH dehydrogenase activity	30/4565	44/18639	0.681818181818182	2.78387931892861	1.16933129587544e-09	3.50267874537233e-08
GO:0017116	single-stranded DNA helicase activity	36/4565	58/18639	0.620689655172414	2.53429013861087	1.35671927497633e-09	3.97368000981956e-08
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	40/4565	68/18639	0.588235294117647	2.40177823593841	1.64542590834565e-09	4.71450292869471e-08
GO:0048027	mRNA 5'-UTR binding	20/4565	24/18639	0.833333333333333	3.40251916757941	2.15738873026937e-09	5.99492564859703e-08
GO:0051536	iron-sulfur cluster binding	43/4565	76/18639	0.565789473684211	2.31013143483023	2.18328096458769e-09	5.99492564859703e-08
GO:0000049	tRNA binding	44/4565	80/18639	0.55	2.24566265060241	4.73317373882833e-09	1.2731271403624e-07
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	35/4565	58/18639	0.603448275862069	2.46389319031612	6.70185999581677e-09	1.7666102948973e-07
GO:0051539	4 iron, 4 sulfur cluster binding	29/4565	45/18639	0.644444444444444	2.63128148959474	1.58904085011014e-08	4.10658007930426e-07
GO:0008173	RNA methyltransferase activity	38/4565	67/18639	0.567164179104478	2.31574438868091	1.6982895858217e-08	4.30451091175576e-07
GO:0000217	DNA secondary structure binding	26/4565	39/18639	0.666666666666667	2.72201533406353	3.11754032073258e-08	7.75267574099159e-07
GO:0055106	ubiquitin-protein transferase regulator activity	24/4565	36/18639	0.666666666666667	2.72201533406353	1.06591601638798e-07	2.60162464740623e-06
GO:0004527	exonuclease activity	43/4565	84/18639	0.511904761904762	2.09011891722735	1.15301073688207e-07	2.76303300220103e-06
GO:0004518	nuclease activity	85/4565	209/18639	0.406698564593301	1.66055959374689	1.6119816548673e-07	3.79391396627696e-06
GO:0000400	four-way junction DNA binding	15/4565	18/18639	0.833333333333333	3.40251916757941	2.51734821538991e-07	5.82081569804193e-06
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	16/4565	20/18639	0.8	3.26641840087623	2.80495403173951e-07	6.27447378930972e-06
GO:0034062	5'-3' RNA polymerase activity	17/4565	22/18639	0.772727272727273	3.15506322811909	2.85636136083902e-07	6.27447378930972e-06
GO:0097747	RNA polymerase activity	17/4565	22/18639	0.772727272727273	3.15506322811909	2.85636136083902e-07	6.27447378930972e-06
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	33/4565	60/18639	0.55	2.24566265060241	3.92196118619363e-07	8.47400794000526e-06
GO:0009982	pseudouridine synthase activity	12/4565	13/18639	0.923076923076923	3.76894430870334	4.63836673483862e-07	9.86026992986661e-06
GO:0055105	ubiquitin-protein transferase inhibitor activity	13/4565	15/18639	0.866666666666667	3.53861993428259	7.07026569189573e-07	1.47914447332041e-05
GO:0016783	sulfurtransferase activity	10/4565	10/18639	1	4.08302300109529	7.70808238996559e-07	1.58738321718354e-05
GO:0070182	DNA polymerase binding	16/4565	21/18639	0.761904761904762	3.11087466750117	9.08360366306082e-07	1.84187532737141e-05
GO:0051082	unfolded protein binding	54/4565	121/18639	0.446280991735537	1.82217555420782	9.79356973958709e-07	1.95574619951148e-05
GO:0001098	basal transcription machinery binding	32/4565	60/18639	0.533333333333333	2.17761226725082	1.46524495723751e-06	2.83998949064564e-05
GO:0001099	basal RNA polymerase II transcription machinery binding	32/4565	60/18639	0.533333333333333	2.17761226725082	1.46524495723751e-06	2.83998949064564e-05
GO:0003714	transcription corepressor activity	80/4565	204/18639	0.392156862745098	1.6011854906256	2.06685420823131e-06	3.94799108180996e-05
GO:0042162	telomeric DNA binding	23/4565	38/18639	0.605263157894737	2.47130339539978	2.46136236166958e-06	4.46743094936936e-05
GO:0009378	four-way junction helicase activity	27/4565	48/18639	0.5625	2.2967004381161	2.47437374282218e-06	4.46743094936936e-05
GO:0036121	double-stranded DNA helicase activity	27/4565	48/18639	0.5625	2.2967004381161	2.47437374282218e-06	4.46743094936936e-05
GO:0043138	3'-5' DNA helicase activity	27/4565	48/18639	0.5625	2.2967004381161	2.47437374282218e-06	4.46743094936936e-05
GO:0003727	single-stranded RNA binding	42/4565	89/18639	0.471910112359551	1.92681984321351	2.63799606043394e-06	4.69848487520531e-05
GO:0043024	ribosomal small subunit binding	15/4565	20/18639	0.75	3.06226725082147	2.84977402923045e-06	5.00800289403431e-05
GO:0017069	snRNA binding	29/4565	54/18639	0.537037037037037	2.19273457466229	3.76016901737812e-06	6.52092469066364e-05
GO:0008175	tRNA methyltransferase activity	21/4565	34/18639	0.617647058823529	2.52186714773533	4.27488590712838e-06	7.31727224103273e-05
GO:0017056	structural constituent of nuclear pore	17/4565	25/18639	0.68	2.7764556407448	5.36944843857967e-06	9.07299107954872e-05
GO:0016874	ligase activity	67/4565	167/18639	0.401197604790419	1.63809904834362	5.48298981528216e-06	9.14757035005302e-05
GO:0031491	nucleosome binding	36/4565	74/18639	0.486486486486487	1.98633551404636	5.62239400139669e-06	9.15084267341507e-05
GO:0016779	nucleotidyltransferase activity	57/4565	136/18639	0.419117647058824	1.71126699310611	5.62381074769818e-06	9.15084267341507e-05
GO:0061749	forked DNA-dependent helicase activity	26/4565	47/18639	0.553191489361702	2.25869357507399	5.76487622968169e-06	9.15434562737405e-05
GO:1990518	single-stranded 3'-5' DNA helicase activity	26/4565	47/18639	0.553191489361702	2.25869357507399	5.76487622968169e-06	9.15434562737405e-05
GO:0043175	RNA polymerase core enzyme binding	24/4565	42/18639	0.571428571428571	2.33315600062588	6.16072428007366e-06	9.66646976325843e-05
GO:0008171	O-methyltransferase activity	16/4565	23/18639	0.695652173913043	2.8403638268489	6.51273030602154e-06	0.000100985629921605
GO:1990948	ubiquitin ligase inhibitor activity	10/4565	11/18639	0.909090909090909	3.71183909190481	6.59417780023848e-06	0.000101059608612957
GO:0008408	3'-5' exonuclease activity	30/4565	58/18639	0.517241379310345	2.11190844884239	7.05468520187713e-06	0.000106874426391656
GO:0004532	RNA exonuclease activity	23/4565	40/18639	0.575	2.34773822562979	8.33246231221152e-06	0.000124261581364719
GO:0015631	tubulin binding	132/4565	385/18639	0.342857142857143	1.39989360037553	8.39095655649468e-06	0.000124261581364719
GO:0016866	intramolecular transferase activity	18/4565	28/18639	0.642857142857143	2.62480050070412	9.36960225617352e-06	0.000137212619707074
GO:0070063	RNA polymerase binding	30/4565	59/18639	0.508474576271186	2.07611339038744	1.10028086392028e-05	0.000159359360290871
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	22/4565	38/18639	0.578947368421053	2.36385542168675	1.12541986690932e-05	0.0001612286287594
GO:0008017	microtubule binding	99/4565	276/18639	0.358695652173913	1.46456259821896	1.39500465069834e-05	0.000196642704092492
GO:0016651	oxidoreductase activity, acting on NAD(P)H	40/4565	88/18639	0.454545454545455	1.8559195459524	1.40245934633492e-05	0.000196642704092492
GO:0000287	magnesium ion binding	85/4565	230/18639	0.369565217391304	1.50894328301348	1.5506843783122e-05	0.000215137053748998
GO:0140517	protein-RNA adaptor activity	15/4565	22/18639	0.681818181818182	2.78387931892861	1.8705486485776e-05	0.0002568107415443
GO:0140030	modification-dependent protein binding	67/4565	173/18639	0.38728323699422	1.58128636458604	2.16414458329902e-05	0.000294055934101867
GO:0031720	haptoglobin binding	9/4565	10/18639	0.9	3.67472070098576	2.45819477377621e-05	0.000327262698165358
GO:0051880	G-quadruplex DNA binding	9/4565	10/18639	0.9	3.67472070098576	2.45819477377621e-05	0.000327262698165358
GO:0140142	nucleocytoplasmic carrier activity	19/4565	32/18639	0.59375	2.42429490690033	2.74159890329127e-05	0.000361342735453789
GO:0016860	intramolecular oxidoreductase activity	27/4565	53/18639	0.509433962264151	2.08003058546364	2.87103334234069e-05	0.000374655638139112
GO:0030983	mismatched DNA binding	11/4565	14/18639	0.785714285714286	3.20808950086059	3.21009406495204e-05	0.000414794507608509
GO:0000175	3'-5'-RNA exonuclease activity	20/4565	35/18639	0.571428571428571	2.33315600062588	3.66919231461323e-05	0.000465052265245721
GO:0035925	mRNA 3'-UTR AU-rich region binding	18/4565	30/18639	0.6	2.44981380065717	3.6696081627887e-05	0.000465052265245721
GO:0140297	DNA-binding transcription factor binding	158/4565	488/18639	0.323770491803279	1.32196236510872	4.10334341280463e-05	0.000515067296959667
GO:0031625	ubiquitin protein ligase binding	104/4565	302/18639	0.344370860927152	1.40607414607255	5.93779083823017e-05	0.000738302672149751
GO:0000993	RNA polymerase II complex binding	20/4565	36/18639	0.555555555555556	2.26834611171961	6.3587666611604e-05	0.000783257426113029
GO:0019205	nucleobase-containing compound kinase activity	23/4565	44/18639	0.522727272727273	2.13430747784527	6.60239750137395e-05	0.000805737028408413
GO:0140034	methylation-dependent protein binding	34/4565	76/18639	0.447368421052632	1.82661555312158	8.9415448649704e-05	0.00108118863596615
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	11/4565	15/18639	0.733333333333333	2.99421686746988	9.35675510078538e-05	0.0011211093838941
GO:0019206	nucleoside kinase activity	9/4565	11/18639	0.818181818181818	3.34065518271433	0.000105526912456618	0.00125301324880922
GO:0070034	telomerase RNA binding	14/4565	22/18639	0.636363636363636	2.59828736433337	0.00011222581517665	0.00132065736073951
GO:0035064	methylated histone binding	33/4565	74/18639	0.445945945945946	1.82080755454249	0.000121696233039672	0.00141943039952467
GO:0004540	RNA nuclease activity	48/4565	121/18639	0.396694214876033	1.61971160374028	0.000152997402777454	0.00176886470930425
GO:0022853	active monoatomic ion transmembrane transporter activity	47/4565	118/18639	0.398305084745763	1.62628882247016	0.000159168213526739	0.00182420613415863
GO:0004536	DNA nuclease activity	29/4565	64/18639	0.453125	1.8501197973713	0.000219313462480283	0.00248343601175539
GO:0005525	GTP binding	123/4565	378/18639	0.325396825396825	1.32860272257863	0.000220456762803779	0.00248343601175539
GO:0044389	ubiquitin-like protein ligase binding	107/4565	322/18639	0.332298136645963	1.35678093514657	0.000229123819634454	0.00255919656167975
GO:0017070	U6 snRNA binding	11/4565	16/18639	0.6875	2.80707831325301	0.000232877346069347	0.00257926337915462
GO:0008276	protein methyltransferase activity	39/4565	95/18639	0.410526315789474	1.67618838992333	0.000268221306193991	0.00294596401303067
GO:0140296	general transcription initiation factor binding	25/4565	53/18639	0.471698113207547	1.92595424579967	0.000272510801899042	0.00296834080085073
GO:0008174	mRNA methyltransferase activity	10/4565	14/18639	0.714285714285714	2.91644500078235	0.00028343258014984	0.00306200115276631
GO:0140223	general transcription initiation factor activity	30/4565	68/18639	0.441176470588235	1.8013336769538	0.000306449665814721	0.00328374519954311
GO:0051087	protein-folding chaperone binding	51/4565	134/18639	0.380597014925373	1.55398636608851	0.000322598051252207	0.00342890509314846
GO:0016423	tRNA (guanine) methyltransferase activity	9/4565	12/18639	0.75	3.06226725082147	0.000329734789107558	0.00346752005930352
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	18/4565	34/18639	0.529411764705882	2.16160041234457	0.000331492812953144	0.00346752005930352
GO:0032356	oxidized DNA binding	8/4565	10/18639	0.8	3.26641840087623	0.000355484679304049	0.00361101490106204
GO:0033204	ribonuclease P RNA binding	8/4565	10/18639	0.8	3.26641840087623	0.000355484679304049	0.00361101490106204
GO:0047429	nucleoside triphosphate diphosphatase activity	8/4565	10/18639	0.8	3.26641840087623	0.000355484679304049	0.00361101490106204
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	23/4565	48/18639	0.479166666666667	1.95644852135816	0.000356169906781537	0.00361101490106204
GO:0051287	NAD binding	25/4565	54/18639	0.462962962962963	1.890288426433	0.000390334682589035	0.00392718405841487
GO:0003725	double-stranded RNA binding	32/4565	75/18639	0.426666666666667	1.74208981380066	0.000409442413058006	0.00405748195797332
GO:0044183	protein folding chaperone	32/4565	75/18639	0.426666666666667	1.74208981380066	0.000409442413058006	0.00405748195797332
GO:0140612	DNA damage sensor activity	14/4565	24/18639	0.583333333333333	2.38176341730559	0.000413139808490022	0.00406356916111828
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	20/4565	40/18639	0.5	2.04151150054764	0.000423408549709023	0.00413372198901105
GO:0032182	ubiquitin-like protein binding	46/4565	120/18639	0.383333333333333	1.56515881708653	0.000513881921757682	0.00498012038879871
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	27/4565	61/18639	0.442622950819672	1.80723968900939	0.000565195032470745	0.00543742374303972
GO:0004519	endonuclease activity	48/4565	127/18639	0.377952755905512	1.54318979568956	0.000571122536146076	0.00545463407710528
GO:0061650	ubiquitin-like protein conjugating enzyme activity	20/4565	41/18639	0.48780487804878	1.99171853711965	0.000637697081706595	0.00604665290423952
GO:0031386	protein tag activity	10/4565	15/18639	0.666666666666667	2.72201533406353	0.000663162638433815	0.0061989245209629
GO:0141047	molecular tag activity	10/4565	15/18639	0.666666666666667	2.72201533406353	0.000663162638433815	0.0061989245209629
GO:0000339	RNA cap binding	12/4565	20/18639	0.6	2.44981380065717	0.000761645860146646	0.00697117530328667
GO:0061608	nuclear import signal receptor activity	12/4565	20/18639	0.6	2.44981380065717	0.000761645860146646	0.00697117530328667
GO:0140664	ATP-dependent DNA damage sensor activity	12/4565	20/18639	0.6	2.44981380065717	0.000761645860146646	0.00697117530328667
GO:0019001	guanyl nucleotide binding	126/4565	400/18639	0.315	1.28615224534502	0.000795373976975112	0.00718015686063834
GO:0032561	guanyl ribonucleotide binding	126/4565	400/18639	0.315	1.28615224534502	0.000795373976975112	0.00718015686063834
GO:0019104	DNA N-glycosylase activity	9/4565	13/18639	0.692307692307692	2.82670823152751	0.000837840608459372	0.00746131028344224
GO:0140666	annealing activity	9/4565	13/18639	0.692307692307692	2.82670823152751	0.000837840608459372	0.00746131028344224
GO:0002039	p53 binding	29/4565	69/18639	0.420289855072464	1.71605314538788	0.00100301426329667	0.00868886666564215
GO:0016879	ligase activity, forming carbon-nitrogen bonds	22/4565	48/18639	0.458333333333333	1.87138554216867	0.0010139044790151	0.00868886666564215
GO:0032404	mismatch repair complex binding	8/4565	11/18639	0.727272727272727	2.96947127352385	0.00102203872423053	0.00868886666564215
GO:0034511	U3 snoRNA binding	8/4565	11/18639	0.727272727272727	2.96947127352385	0.00102203872423053	0.00868886666564215
GO:0070990	snRNP binding	8/4565	11/18639	0.727272727272727	2.96947127352385	0.00102203872423053	0.00868886666564215
GO:0003746	translation elongation factor activity	11/4565	18/18639	0.611111111111111	2.49518072289157	0.00102842427908966	0.00868886666564215
GO:0070628	proteasome binding	11/4565	18/18639	0.611111111111111	2.49518072289157	0.00102842427908966	0.00868886666564215
GO:0098641	cadherin binding involved in cell-cell adhesion	11/4565	18/18639	0.611111111111111	2.49518072289157	0.00102842427908966	0.00868886666564215
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	26/4565	60/18639	0.433333333333333	1.76930996714129	0.00104605655387068	0.0087279356210965
GO:0140463	chromatin-protein adaptor activity	24/4565	54/18639	0.444444444444444	1.81467688937568	0.00104629273758213	0.0087279356210965
GO:0008170	N-methyltransferase activity	38/4565	98/18639	0.387755102040816	1.5832130004247	0.00117749978468752	0.00976065859256702
GO:0140662	ATP-dependent protein folding chaperone	19/4565	40/18639	0.475	1.93943592552026	0.00130012487320723	0.0107097786430446
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	20/4565	43/18639	0.465116279069767	1.89908046562572	0.00135582811637361	0.0110992637104374
GO:0043023	ribosomal large subunit binding	10/4565	16/18639	0.625	2.55188937568456	0.00138030479237459	0.0112298871379612
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	21/4565	46/18639	0.456521739130435	1.86398876136959	0.00139477425378666	0.0112779905919682
GO:0016829	lyase activity	68/4565	200/18639	0.34	1.3882278203724	0.00150958456690742	0.0121319052389267
GO:0005344	oxygen carrier activity	9/4565	14/18639	0.642857142857143	2.62480050070412	0.00183577505941652	0.0144883325048562
GO:0008474	palmitoyl-(protein) hydrolase activity	9/4565	14/18639	0.642857142857143	2.62480050070412	0.00183577505941652	0.0144883325048562
GO:0098599	palmitoyl hydrolase activity	9/4565	14/18639	0.642857142857143	2.62480050070412	0.00183577505941652	0.0144883325048562
GO:0016251	RNA polymerase II general transcription initiation factor activity	23/4565	53/18639	0.433962264150943	1.77187790613569	0.00194773360301811	0.015280433861773
GO:0008649	rRNA methyltransferase activity	12/4565	22/18639	0.545454545454545	2.22710345514289	0.00236704032328556	0.0183350301243931
GO:0004526	ribonuclease P activity	8/4565	12/18639	0.666666666666667	2.72201533406353	0.00240664659447648	0.0183350301243931
GO:0016273	arginine N-methyltransferase activity	8/4565	12/18639	0.666666666666667	2.72201533406353	0.00240664659447648	0.0183350301243931
GO:0016274	protein-arginine N-methyltransferase activity	8/4565	12/18639	0.666666666666667	2.72201533406353	0.00240664659447648	0.0183350301243931
GO:1990247	N6-methyladenosine-containing RNA reader activity	8/4565	12/18639	0.666666666666667	2.72201533406353	0.00240664659447648	0.0183350301243931
GO:0140838	RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity	17/4565	36/18639	0.472222222222222	1.92809419496166	0.00249729811882119	0.018701357503445
GO:0140839	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	17/4565	36/18639	0.472222222222222	1.92809419496166	0.00249729811882119	0.018701357503445
GO:0140840	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	17/4565	36/18639	0.472222222222222	1.92809419496166	0.00249729811882119	0.018701357503445
GO:0004549	tRNA-specific ribonuclease activity	10/4565	17/18639	0.588235294117647	2.40177823593841	0.00261855927911697	0.0192807884350624
GO:0004659	prenyltransferase activity	10/4565	17/18639	0.588235294117647	2.40177823593841	0.00261855927911697	0.0192807884350624
GO:0070402	NADPH binding	10/4565	17/18639	0.588235294117647	2.40177823593841	0.00261855927911697	0.0192807884350624
GO:0019787	ubiquitin-like protein transferase activity	144/4565	479/18639	0.30062630480167	1.2274641172395	0.00284712817139961	0.0208473051661372
GO:0046966	nuclear thyroid hormone receptor binding	14/4565	28/18639	0.5	2.04151150054764	0.00306330172687321	0.0215910655488199
GO:0051537	2 iron, 2 sulfur cluster binding	14/4565	28/18639	0.5	2.04151150054764	0.00306330172687321	0.0215910655488199
GO:0001094	TFIID-class transcription factor complex binding	7/4565	10/18639	0.7	2.8581161007667	0.00307975745309419	0.0215910655488199
GO:0008641	ubiquitin-like modifier activating enzyme activity	7/4565	10/18639	0.7	2.8581161007667	0.00307975745309419	0.0215910655488199
GO:0016427	tRNA (cytidine) methyltransferase activity	7/4565	10/18639	0.7	2.8581161007667	0.00307975745309419	0.0215910655488199
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	7/4565	10/18639	0.7	2.8581161007667	0.00307975745309419	0.0215910655488199
GO:0050815	phosphoserine residue binding	7/4565	10/18639	0.7	2.8581161007667	0.00307975745309419	0.0215910655488199
GO:0097177	mitochondrial ribosome binding	7/4565	10/18639	0.7	2.8581161007667	0.00307975745309419	0.0215910655488199
GO:0000774	adenyl-nucleotide exchange factor activity	9/4565	15/18639	0.6	2.44981380065717	0.00359469369089059	0.0250677581195439
GO:0003887	DNA-directed DNA polymerase activity	12/4565	23/18639	0.521739130434783	2.13027287013667	0.00385480097685076	0.026600144960677
GO:0140102	catalytic activity, acting on a rRNA	12/4565	23/18639	0.521739130434783	2.13027287013667	0.00385480097685076	0.026600144960677
GO:0031072	heat shock protein binding	46/4565	131/18639	0.351145038167939	1.43373326756018	0.00407923779578089	0.0280022677856209
GO:0004529	DNA exonuclease activity	13/4565	26/18639	0.5	2.04151150054764	0.00428529563957143	0.0292643505334463
GO:0051059	NF-kappaB binding	15/4565	32/18639	0.46875	1.91391703176342	0.00481911515215343	0.0325722757463498
GO:0070717	poly-purine tract binding	15/4565	32/18639	0.46875	1.91391703176342	0.00481911515215343	0.0325722757463498
GO:0140938	histone H3 methyltransferase activity	20/4565	47/18639	0.425531914893617	1.73745659621076	0.00491110212842115	0.0328947120549893
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	8/4565	13/18639	0.615384615384615	2.51262953913556	0.00491673617210386	0.0328947120549893
GO:0140566	histone reader activity	16/4565	35/18639	0.457142857142857	1.8665248005007	0.00495258112291195	0.0329671814141311
GO:0016835	carbon-oxygen lyase activity	30/4565	79/18639	0.379746835443038	1.55051506370707	0.00526854596977334	0.0348941888852325
GO:0004601	peroxidase activity	23/4565	57/18639	0.403508771929825	1.64753559693319	0.00587980324017223	0.038747903352735
GO:0001091	RNA polymerase II general transcription initiation factor binding	12/4565	24/18639	0.5	2.04151150054764	0.00600892778369705	0.039401824969715
GO:0016755	aminoacyltransferase activity	146/4565	496/18639	0.294354838709677	1.20185757693531	0.00620507595885445	0.0403140114736887
GO:0051219	phosphoprotein binding	34/4565	93/18639	0.365591397849462	1.49271808642193	0.00620921421028742	0.0403140114736887
GO:0005048	signal sequence binding	21/4565	51/18639	0.411764705882353	1.68124476515688	0.00631778397827478	0.040817839624344
GO:0008320	protein transmembrane transporter activity	13/4565	27/18639	0.481481481481481	1.96589996349032	0.00643305220004337	0.0412147885619649
GO:0097027	ubiquitin-protein transferase activator activity	9/4565	16/18639	0.5625	2.2967004381161	0.00644176513183974	0.0412147885619649
GO:0042054	histone methyltransferase activity	26/4565	67/18639	0.388059701492537	1.5844566869922	0.00651376325313655	0.0414741061238356
GO:0043130	ubiquitin binding	36/4565	100/18639	0.36	1.4698882803943	0.00658297507062974	0.0417132747263942
GO:0008187	poly-pyrimidine tract binding	14/4565	30/18639	0.466666666666667	1.90541073384447	0.00670840527070342	0.042304680128168
GO:0004520	DNA endonuclease activity	18/4565	42/18639	0.428571428571429	1.74986700046941	0.0068097099509102	0.0423358382797153
GO:0016859	cis-trans isomerase activity	18/4565	42/18639	0.428571428571429	1.74986700046941	0.0068097099509102	0.0423358382797153
GO:0031492	nucleosomal DNA binding	18/4565	42/18639	0.428571428571429	1.74986700046941	0.0068097099509102	0.0423358382797153
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	15/4565	33/18639	0.454545454545455	1.8559195459524	0.00686174900708528	0.0424582261444954
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	17/4565	39/18639	0.435897435897436	1.77977925688769	0.00689382427535813	0.0424582261444954
GO:0019887	protein kinase regulator activity	80/4565	255/18639	0.313725490196078	1.28094839250048	0.00725778128885643	0.0444918871568036
GO:0140299	molecular sensor activity	27/4565	71/18639	0.380281690140845	1.55269888774046	0.00769729199170095	0.0469677353938049
GO:0060590	ATPase regulator activity	20/4565	49/18639	0.408163265306122	1.66654000044706	0.00851248878449271	0.0517025816495916
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	12/4565	25/18639	0.48	1.95985104052574	0.00901308881094533	0.0540660633493732
GO:0098847	sequence-specific single stranded DNA binding	8/4565	14/18639	0.571428571428571	2.33315600062588	0.00902468432235364	0.0540660633493732
GO:1990825	sequence-specific mRNA binding	8/4565	14/18639	0.571428571428571	2.33315600062588	0.00902468432235364	0.0540660633493732
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	23/4565	59/18639	0.389830508474576	1.59168693263037	0.00952631395924094	0.0563956364238359
GO:0045309	protein phosphorylated amino acid binding	23/4565	59/18639	0.389830508474576	1.59168693263037	0.00952631395924094	0.0563956364238359
GO:0015035	protein-disulfide reductase activity	15/4565	34/18639	0.441176470588235	1.8013336769538	0.00954190206564143	0.0563956364238359
GO:0032977	membrane insertase activity	9/4565	17/18639	0.529411764705882	2.16160041234457	0.0107428717161528	0.0632102898298635
GO:0050660	flavin adenine dinucleotide binding	31/4565	86/18639	0.36046511627907	1.47178736085993	0.0109000519881851	0.0638500823130132
GO:0140939	histone H4 methyltransferase activity	10/4565	20/18639	0.5	2.04151150054764	0.0119189149696735	0.0695094244691578
GO:0004812	aminoacyl-tRNA ligase activity	17/4565	41/18639	0.414634146341463	1.69296075655171	0.0123266313222941	0.0712565793104542
GO:0016875	ligase activity, forming carbon-oxygen bonds	17/4565	41/18639	0.414634146341463	1.69296075655171	0.0123266313222941	0.0712565793104542
GO:0140994	RNA polymerase II CTD heptapeptide repeat modifying activity	43/4565	128/18639	0.3359375	1.37164053943045	0.0126073688023334	0.0713327020299026
GO:0000340	RNA 7-methylguanosine cap binding	7/4565	12/18639	0.583333333333333	2.38176341730559	0.0126645313163864	0.0713327020299026
GO:0000995	RNA polymerase III general transcription initiation factor activity	7/4565	12/18639	0.583333333333333	2.38176341730559	0.0126645313163864	0.0713327020299026
GO:0005049	nuclear export signal receptor activity	7/4565	12/18639	0.583333333333333	2.38176341730559	0.0126645313163864	0.0713327020299026
GO:0043047	single-stranded telomeric DNA binding	7/4565	12/18639	0.583333333333333	2.38176341730559	0.0126645313163864	0.0713327020299026
GO:0097371	MDM2/MDM4 family protein binding	7/4565	12/18639	0.583333333333333	2.38176341730559	0.0126645313163864	0.0713327020299026
GO:0034061	DNA polymerase activity	15/4565	35/18639	0.428571428571429	1.74986700046941	0.0129838927726886	0.0725117401457777
GO:0061631	ubiquitin conjugating enzyme activity	15/4565	35/18639	0.428571428571429	1.74986700046941	0.0129838927726886	0.0725117401457777
GO:0031369	translation initiation factor binding	14/4565	32/18639	0.4375	1.78632256297919	0.0131705298167803	0.0732437059009131
GO:0004860	protein kinase inhibitor activity	30/4565	84/18639	0.357142857142857	1.45822250039118	0.0139450996815518	0.0772253839507786
GO:0042809	nuclear vitamin D receptor binding	8/4565	15/18639	0.533333333333333	2.17761226725082	0.0152303879011686	0.0839901726097914
GO:1990841	promoter-specific chromatin binding	25/4565	68/18639	0.367647058823529	1.5011113974615	0.0160505270256542	0.0881441442492174
GO:0004842	ubiquitin-protein transferase activity	130/4565	449/18639	0.289532293986637	1.18216701590732	0.0161956020753028	0.0885717989014483
GO:0016776	phosphotransferase activity, phosphate group as acceptor	16/4565	39/18639	0.41025641025641	1.67508635942371	0.0167267418017386	0.0910458218623768
GO:0051020	GTPase binding	94/4565	315/18639	0.298412698412698	1.21842591143796	0.016786141663549	0.0910458218623768
GO:0008409	5'-3' exonuclease activity	9/4565	18/18639	0.5	2.04151150054764	0.0168795154031546	0.0911770545137612
GO:0008013	beta-catenin binding	36/4565	106/18639	0.339622641509434	1.38668705697576	0.0177331772558851	0.0922424100720867
GO:0000182	rDNA binding	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:0001164	RNA polymerase I core promoter sequence-specific DNA binding	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:0043295	glutathione binding	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:0098505	G-rich strand telomeric DNA binding	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:0140940	histone H2A methyltransferase activity	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:1990259	histone H2AQ104 methyltransferase activity	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:1990757	ubiquitin ligase activator activity	6/4565	10/18639	0.6	2.44981380065717	0.0177942066415131	0.0922424100720867
GO:0010314	phosphatidylinositol-5-phosphate binding	10/4565	21/18639	0.476190476190476	1.94429666718823	0.0178378707519905	0.0922424100720867
GO:1904047	S-adenosyl-L-methionine binding	10/4565	21/18639	0.476190476190476	1.94429666718823	0.0178378707519905	0.0922424100720867
GO:0015399	primary active transmembrane transporter activity	53/4565	166/18639	0.319277108433735	1.30361577745813	0.0178465967893643	0.0922424100720867
GO:0019207	kinase regulator activity	86/4565	287/18639	0.299651567944251	1.22348424423064	0.0192657112997065	0.0991883105195826
GO:0016209	antioxidant activity	30/4565	86/18639	0.348837209302326	1.42431034921929	0.0196755178133738	0.100904017424228
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	70/4565	229/18639	0.305676855895196	1.24808563352258	0.02083116484111	0.106416570777453
GO:0019210	kinase inhibitor activity	31/4565	90/18639	0.344444444444444	1.40637458926616	0.0215874538778764	0.109180834383673
GO:0015036	disulfide oxidoreductase activity	16/4565	40/18639	0.4	1.63320920043812	0.0216787964312429	0.109180834383673
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	7/4565	13/18639	0.538461538461538	2.19855084674362	0.0217036256513826	0.109180834383673
GO:0046975	histone H3K36 methyltransferase activity	7/4565	13/18639	0.538461538461538	2.19855084674362	0.0217036256513826	0.109180834383673
GO:0034212	protein N-acetyltransferase activity	20/4565	53/18639	0.377358490566038	1.54076339663973	0.0219273382661438	0.109886813059991
GO:0030275	LRR domain binding	8/4565	16/18639	0.5	2.04151150054764	0.0240190106704974	0.119913091150438
GO:0097718	disordered domain specific binding	12/4565	28/18639	0.428571428571429	1.74986700046941	0.0251348712795334	0.124976423552756
GO:0008301	DNA binding, bending	9/4565	19/18639	0.473684210526316	1.93406352683461	0.0252228593816639	0.124976423552756
GO:0017025	TBP-class protein binding	11/4565	25/18639	0.44	1.79653012048193	0.0255768272058171	0.126255648903622
GO:0001046	core promoter sequence-specific DNA binding	17/4565	44/18639	0.386363636363636	1.57753161405954	0.0261640980205923	0.128194353870411
GO:0016790	thiolester hydrolase activity	17/4565	44/18639	0.386363636363636	1.57753161405954	0.0261640980205923	0.128194353870411
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	20/4565	54/18639	0.37037037037037	1.5122307411464	0.0270066454331941	0.131832439559074
GO:0016877	ligase activity, forming carbon-sulfur bonds	16/4565	41/18639	0.390243902439024	1.59337482969572	0.0276641821009702	0.134049235327495
GO:0140318	protein transporter activity	16/4565	41/18639	0.390243902439024	1.59337482969572	0.0276641821009702	0.134049235327495
GO:0016830	carbon-carbon lyase activity	19/4565	51/18639	0.372549019607843	1.52112621609432	0.0288056174764753	0.1390688785128
GO:0001163	RNA polymerase I transcription regulatory region sequence-specific DNA binding	6/4565	11/18639	0.545454545454545	2.22710345514289	0.0311303363370021	0.148658635116554
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	6/4565	11/18639	0.545454545454545	2.22710345514289	0.0311303363370021	0.148658635116554
GO:1900750	oligopeptide binding	6/4565	11/18639	0.545454545454545	2.22710345514289	0.0311303363370021	0.148658635116554
GO:0016407	acetyltransferase activity	32/4565	96/18639	0.333333333333333	1.36100766703176	0.0316373142866498	0.150534224656334
GO:0022884	macromolecule transmembrane transporter activity	13/4565	32/18639	0.40625	1.65872809419496	0.0321722963435115	0.152529088419957
GO:0016417	S-acyltransferase activity	12/4565	29/18639	0.413793103448276	1.68952675907391	0.0335494198199432	0.158487940224678
GO:0008143	poly(A) binding	11/4565	26/18639	0.423076923076923	1.7274328081557	0.034751812987669	0.163197740665007
GO:0004402	histone acetyltransferase activity	16/4565	42/18639	0.380952380952381	1.55543733375059	0.0347940554832072	0.163197740665007
GO:0008080	N-acetyltransferase activity	24/4565	69/18639	0.347826086956522	1.42018191342445	0.0355497744424202	0.165072693748271
GO:0070577	lysine-acetylated histone binding	10/4565	23/18639	0.434782608695652	1.77522739178056	0.0356628893351116	0.165072693748271
GO:0004029	aldehyde dehydrogenase (NAD+) activity	8/4565	17/18639	0.470588235294118	1.92142258875073	0.0358200230743592	0.165072693748271
GO:0004550	nucleoside diphosphate kinase activity	8/4565	17/18639	0.470588235294118	1.92142258875073	0.0358200230743592	0.165072693748271
GO:0032183	SUMO binding	8/4565	17/18639	0.470588235294118	1.92142258875073	0.0358200230743592	0.165072693748271
GO:0036002	pre-mRNA binding	21/4565	59/18639	0.355932203389831	1.45327937327121	0.0370320278043067	0.17006345869713
GO:0004521	RNA endonuclease activity	25/4565	73/18639	0.342465753424658	1.3982955483203	0.0389329394264972	0.178172271403206
GO:0044390	ubiquitin-like protein conjugating enzyme binding	14/4565	36/18639	0.388888888888889	1.58784227820372	0.0392150027609232	0.178842123317982
GO:0030291	protein serine/threonine kinase inhibitor activity	17/4565	46/18639	0.369565217391304	1.50894328301348	0.0403664968369492	0.1834587683831
GO:0061659	ubiquitin-like protein ligase activity	106/4565	372/18639	0.28494623655914	1.16344203794651	0.0414722139568262	0.187836350498615
GO:0016278	lysine N-methyltransferase activity	24/4565	70/18639	0.342857142857143	1.39989360037553	0.0418959410116942	0.189105651552784
GO:0008266	poly(U) RNA binding	11/4565	27/18639	0.407407407407407	1.66345381526104	0.0460133279663916	0.206981454811277
GO:0070279	vitamin B6 binding	20/4565	57/18639	0.350877192982456	1.43263964950712	0.0475716127067181	0.213263216147804
GO:0140033	acetylation-dependent protein binding	10/4565	24/18639	0.416666666666667	1.7012595837897	0.0480729657801388	0.214780233553298
GO:0061733	protein-lysine-acetyltransferase activity	17/4565	47/18639	0.361702127659574	1.47683810677915	0.0492435551502831	0.217892381031135
GO:0003995	acyl-CoA dehydrogenase activity	6/4565	12/18639	0.5	2.04151150054764	0.0495961413576179	0.217892381031135
GO:0017166	vinculin binding	6/4565	12/18639	0.5	2.04151150054764	0.0495961413576179	0.217892381031135
GO:0036009	protein-glutamine N-methyltransferase activity	6/4565	12/18639	0.5	2.04151150054764	0.0495961413576179	0.217892381031135
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	6/4565	12/18639	0.5	2.04151150054764	0.0495961413576179	0.217892381031135
GO:0019200	carbohydrate kinase activity	9/4565	21/18639	0.428571428571429	1.74986700046941	0.0498104303529054	0.218106801345945
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	8/4565	18/18639	0.444444444444444	1.81467688937568	0.050972429211323	0.222020443640031
GO:0140776	protein-containing complex destabilizing activity	7/4565	15/18639	0.466666666666667	1.90541073384447	0.0511407236747492	0.222020443640031
GO:0050661	NADP binding	19/4565	54/18639	0.351851851851852	1.43661920408908	0.0512095712189449	0.222020443640031
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	99/4565	349/18639	0.283667621776504	1.15822142437947	0.0525279297883716	0.226454117675779
GO:0030332	cyclin binding	13/4565	34/18639	0.382352941176471	1.56115585335996	0.0525758421917968	0.226454117675779
GO:0070273	phosphatidylinositol-4-phosphate binding	12/4565	31/18639	0.387096774193548	1.58052503268205	0.0560021047866513	0.240133551835254
GO:0003924	GTPase activity	94/4565	331/18639	0.283987915407855	1.15952919064338	0.0561161866200746	0.240133551835254
GO:0019903	protein phosphatase binding	44/4565	144/18639	0.305555555555556	1.24759036144578	0.0571365184471473	0.243708515577153
GO:0019789	SUMO transferase activity	11/4565	28/18639	0.392857142857143	1.60404475043029	0.0595229175872999	0.252254679678654
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	11/4565	28/18639	0.392857142857143	1.60404475043029	0.0595229175872999	0.252254679678654
GO:0098632	cell-cell adhesion mediator activity	19/4565	55/18639	0.345454545454545	1.41049885492383	0.060858799430192	0.257089415541644
GO:0031267	small GTPase binding	81/4565	283/18639	0.286219081272085	1.16863909218628	0.0613393273382417	0.258127036770971
GO:0016279	protein-lysine N-methyltransferase activity	23/4565	69/18639	0.333333333333333	1.36100766703176	0.0614961225691085	0.258127036770971
GO:0008483	transaminase activity	10/4565	25/18639	0.4	1.63320920043812	0.0630703914963531	0.263894526959344
GO:0042826	histone deacetylase binding	39/4565	127/18639	0.307086614173228	1.25384170899777	0.0653793467402881	0.272343203730807
GO:0010485	histone H4 acetyltransferase activity	13/4565	35/18639	0.371428571428571	1.51655140040682	0.0655028798047541	0.272343203730807
GO:0061630	ubiquitin protein ligase activity	99/4565	353/18639	0.280453257790368	1.14509710229018	0.0676925470089029	0.280562191690987
GO:0035198	miRNA binding	15/4565	42/18639	0.357142857142857	1.45822250039118	0.0690369482263407	0.284345930507241
GO:0051879	Hsp90 protein binding	15/4565	42/18639	0.357142857142857	1.45822250039118	0.0690369482263407	0.284345930507241
GO:0008574	plus-end-directed microtubule motor activity	8/4565	19/18639	0.421052631578947	1.71916757940854	0.0696993890874387	0.286180046159639
GO:0030170	pyridoxal phosphate binding	19/4565	56/18639	0.339285714285714	1.38531137537162	0.0716935666371206	0.29042769259482
GO:0019842	vitamin binding	45/4565	150/18639	0.3	1.22490690032859	0.0717013243130287	0.29042769259482
GO:0008296	3'-5'-DNA exonuclease activity	7/4565	16/18639	0.4375	1.78632256297919	0.0722353893447227	0.29042769259482
GO:0016868	intramolecular phosphotransferase activity	5/4565	10/18639	0.5	2.04151150054764	0.0722763908733695	0.29042769259482
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	5/4565	10/18639	0.5	2.04151150054764	0.0722763908733695	0.29042769259482
GO:0031996	thioesterase binding	5/4565	10/18639	0.5	2.04151150054764	0.0722763908733695	0.29042769259482
GO:0099122	RNA polymerase II C-terminal domain binding	5/4565	10/18639	0.5	2.04151150054764	0.0722763908733695	0.29042769259482
GO:0005338	nucleotide-sugar transmembrane transporter activity	6/4565	13/18639	0.461538461538462	1.88447215435167	0.0735040119629627	0.290925789090645
GO:0005542	folic acid binding	6/4565	13/18639	0.461538461538462	1.88447215435167	0.0735040119629627	0.290925789090645
GO:0019855	calcium channel inhibitor activity	6/4565	13/18639	0.461538461538462	1.88447215435167	0.0735040119629627	0.290925789090645
GO:0097157	pre-mRNA intronic binding	6/4565	13/18639	0.461538461538462	1.88447215435167	0.0735040119629627	0.290925789090645
GO:0140852	histone ubiquitin ligase activity	6/4565	13/18639	0.461538461538462	1.88447215435167	0.0735040119629627	0.290925789090645
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	40/4565	132/18639	0.303030303030303	1.2372796973016	0.0749287439496263	0.295676899777268
GO:0016409	palmitoyltransferase activity	13/4565	36/18639	0.361111111111111	1.47442497261774	0.0803612450903977	0.316167525460132
GO:0008198	ferrous iron binding	10/4565	26/18639	0.384615384615385	1.57039346195973	0.0807695030642806	0.316827991186672
GO:0015078	proton transmembrane transporter activity	54/4565	185/18639	0.291891891891892	1.19180130842781	0.0815291636553241	0.318858865571861
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	37/4565	122/18639	0.30327868852459	1.23829386098792	0.0832156726498477	0.324491883291418
GO:0015932	nucleobase-containing compound transmembrane transporter activity	19/4565	57/18639	0.333333333333333	1.36100766703176	0.0837545436023221	0.325037190717292
GO:0015605	organophosphate ester transmembrane transporter activity	17/4565	50/18639	0.34	1.3882278203724	0.0838487441911071	0.325037190717292
GO:0016922	nuclear receptor binding	41/4565	137/18639	0.299270072992701	1.22192659156866	0.0850563541312541	0.328751538841621
GO:0017134	fibroblast growth factor binding	9/4565	23/18639	0.391304347826087	1.5977046526025	0.0863709628866097	0.332856517791086
GO:0061791	GTPase motor activity	14/4565	40/18639	0.35	1.42905805038335	0.0897191508198655	0.343749537152857
GO:1990606	membrane scission GTPase motor activity	14/4565	40/18639	0.35	1.42905805038335	0.0897191508198655	0.343749537152857
GO:0019902	phosphatase binding	55/4565	190/18639	0.289473684210526	1.18192771084337	0.0900510792299716	0.344021224420587
GO:0016769	transferase activity, transferring nitrogenous groups	11/4565	30/18639	0.366666666666667	1.49710843373494	0.0936938958113396	0.355874797346817
GO:0051721	protein phosphatase 2A binding	11/4565	30/18639	0.366666666666667	1.49710843373494	0.0936938958113396	0.355874797346817
GO:0003774	cytoskeletal motor activity	45/4565	153/18639	0.294117647058824	1.2008891179692	0.094055625305315	0.356222167104612
GO:0061980	regulatory RNA binding	19/4565	58/18639	0.327586206896552	1.33754201760018	0.0970696193207083	0.366583834569323
GO:0001671	ATPase activator activity	10/4565	27/18639	0.37037037037037	1.5122307411464	0.101214311945392	0.381144180411504
GO:0016530	metallochaperone activity	6/4565	14/18639	0.428571428571429	1.74986700046941	0.102845095699876	0.385084761739876
GO:0070742	C2H2 zinc finger domain binding	6/4565	14/18639	0.428571428571429	1.74986700046941	0.102845095699876	0.385084761739876
GO:0016831	carboxy-lyase activity	12/4565	34/18639	0.352941176470588	1.44106694156304	0.105399812055418	0.387989962440731
GO:0043539	protein serine/threonine kinase activator activity	23/4565	73/18639	0.315068493150685	1.28643190445468	0.105799148736191	0.387989962440731
GO:0032266	phosphatidylinositol-3-phosphate binding	16/4565	48/18639	0.333333333333333	1.36100766703176	0.106486627814411	0.387989962440731
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0004523	RNA-DNA hybrid ribonuclease activity	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0015217	ADP transmembrane transporter activity	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0032794	GTPase activating protein binding	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0045294	alpha-catenin binding	5/4565	11/18639	0.454545454545455	1.8559195459524	0.106564769653676	0.387989962440731
GO:0050699	WW domain binding	9/4565	24/18639	0.375	1.53113362541073	0.109349761150492	0.397033017069831
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	8/4565	21/18639	0.380952380952381	1.55543733375059	0.118114192915532	0.426505496610059
GO:0140312	cargo adaptor activity	8/4565	21/18639	0.380952380952381	1.55543733375059	0.118114192915532	0.426505496610059
GO:0001221	transcription coregulator binding	34/4565	115/18639	0.295652173913043	1.20715462641078	0.124012618424578	0.446580959244793
GO:0043015	gamma-tubulin binding	12/4565	35/18639	0.342857142857143	1.39989360037553	0.126215602794895	0.453275652544065
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	7/4565	18/18639	0.388888888888889	1.58784227820372	0.127478510793848	0.454099127638626
GO:0035615	clathrin adaptor activity	7/4565	18/18639	0.388888888888889	1.58784227820372	0.127478510793848	0.454099127638626
GO:0070064	proline-rich region binding	7/4565	18/18639	0.388888888888889	1.58784227820372	0.127478510793848	0.454099127638626
GO:0019003	GDP binding	23/4565	75/18639	0.306666666666667	1.25212705366922	0.134020930442417	0.476117483350688
GO:0004129	cytochrome-c oxidase activity	6/4565	15/18639	0.4	1.63320920043812	0.13731467704996	0.482615318271593
GO:0008252	nucleotidase activity	6/4565	15/18639	0.4	1.63320920043812	0.13731467704996	0.482615318271593
GO:0015556	C4-dicarboxylate transmembrane transporter activity	6/4565	15/18639	0.4	1.63320920043812	0.13731467704996	0.482615318271593
GO:0061578	K63-linked deubiquitinase activity	6/4565	15/18639	0.4	1.63320920043812	0.13731467704996	0.482615318271593
GO:0003777	microtubule motor activity	21/4565	68/18639	0.308823529411765	1.26093357386766	0.139291352723376	0.488260645982472
GO:0016410	N-acyltransferase activity	28/4565	94/18639	0.297872340425532	1.21621961734753	0.141314377526762	0.494038062547142
GO:0031490	chromatin DNA binding	37/4565	128/18639	0.2890625	1.18024883625411	0.144405115280369	0.501355082322928
GO:0016836	hydro-lyase activity	19/4565	61/18639	0.311475409836066	1.27176126263624	0.144607632229861	0.501355082322928
GO:0005095	GTPase inhibitor activity	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0035197	siRNA binding	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0140822	NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0140844	NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0140867	NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	5/4565	12/18639	0.416666666666667	1.7012595837897	0.147256647008003	0.501355082322928
GO:0004407	histone deacetylase activity	8/4565	22/18639	0.363636363636364	1.48473563676192	0.147591632732395	0.501355082322928
GO:0033558	protein lysine deacetylase activity	8/4565	22/18639	0.363636363636364	1.48473563676192	0.147591632732395	0.501355082322928
GO:0003925	G protein activity	17/4565	54/18639	0.314814814814815	1.28539612997444	0.149871326978416	0.507790254389593
GO:0160215	deacylase activity	20/4565	65/18639	0.307692307692308	1.25631476956778	0.15059462158902	0.508932592959817
GO:0051117	ATPase binding	25/4565	84/18639	0.297619047619048	1.21518541699265	0.158809482801694	0.535321990620543
GO:0050145	nucleoside monophosphate kinase activity	7/4565	19/18639	0.368421052631579	1.50427163198248	0.16118299845592	0.541936714196181
GO:0001223	transcription coactivator binding	14/4565	44/18639	0.318181818181818	1.29914368216668	0.168653172347436	0.565610384615575
GO:0019213	deacetylase activity	12/4565	37/18639	0.324324324324324	1.32422367603091	0.174077613799953	0.582320545655679
GO:0016675	oxidoreductase activity, acting on a heme group of donors	6/4565	16/18639	0.375	1.53113362541073	0.176362249673103	0.585709071680387
GO:0034450	ubiquitin-ubiquitin ligase activity	6/4565	16/18639	0.375	1.53113362541073	0.176362249673103	0.585709071680387
GO:0031593	polyubiquitin modification-dependent protein binding	18/4565	59/18639	0.305084745762712	1.24566803423246	0.176423749208736	0.585709071680387
GO:0004602	glutathione peroxidase activity	8/4565	23/18639	0.347826086956522	1.42018191342445	0.180242656650147	0.596883973529883
GO:0019212	phosphatase inhibitor activity	17/4565	56/18639	0.303571428571429	1.2394891253325	0.191196056091137	0.629229614505924
GO:0004535	poly(A)-specific ribonuclease activity	5/4565	13/18639	0.384615384615385	1.57039346195973	0.193352043911153	0.629229614505924
GO:0008253	5'-nucleotidase activity	5/4565	13/18639	0.384615384615385	1.57039346195973	0.193352043911153	0.629229614505924
GO:0045159	myosin II binding	5/4565	13/18639	0.384615384615385	1.57039346195973	0.193352043911153	0.629229614505924
GO:0046974	histone H3K9 methyltransferase activity	5/4565	13/18639	0.384615384615385	1.57039346195973	0.193352043911153	0.629229614505924
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	5/4565	13/18639	0.384615384615385	1.57039346195973	0.193352043911153	0.629229614505924
GO:0140806	NAD+-protein-aspartate ADP-ribosyltransferase activity	5/4565	13/18639	0.384615384615385	1.57039346195973	0.193352043911153	0.629229614505924
GO:0005385	zinc ion transmembrane transporter activity	9/4565	27/18639	0.333333333333333	1.36100766703176	0.195834377279603	0.635738200134279
GO:0016763	pentosyltransferase activity	15/4565	49/18639	0.306122448979592	1.24990500033529	0.200399418060194	0.648910638184954
GO:0043531	ADP binding	12/4565	38/18639	0.315789473684211	1.28937568455641	0.200876737768939	0.648910638184954
GO:0019208	phosphatase regulator activity	33/4565	117/18639	0.282051282051282	1.1516218721038	0.201891355547263	0.650593659196313
GO:1901505	carbohydrate derivative transmembrane transporter activity	16/4565	53/18639	0.30188679245283	1.23261071731179	0.20740197644991	0.666721475514588
GO:0008327	methyl-CpG binding	10/4565	31/18639	0.32258064516129	1.31710419390171	0.208844258033347	0.669724408973118
GO:0008307	structural constituent of muscle	13/4565	42/18639	0.30952380952381	1.26379283367235	0.210003620720319	0.670181046269687
GO:0048487	beta-tubulin binding	13/4565	42/18639	0.30952380952381	1.26379283367235	0.210003620720319	0.670181046269687
GO:0005345	purine nucleobase transmembrane transporter activity	4/4565	10/18639	0.4	1.63320920043812	0.212324233078659	0.674321299271499
GO:0005522	profilin binding	4/4565	10/18639	0.4	1.63320920043812	0.212324233078659	0.674321299271499
GO:0043998	histone H2A acetyltransferase activity	8/4565	24/18639	0.333333333333333	1.36100766703176	0.215689104399974	0.6817223971203
GO:0070840	dynein complex binding	8/4565	24/18639	0.333333333333333	1.36100766703176	0.215689104399974	0.6817223971203
GO:0098631	cell adhesion mediator activity	22/4565	76/18639	0.289473684210526	1.18192771084337	0.21752760332599	0.684781173139003
GO:0016018	cyclosporin A binding	6/4565	17/18639	0.352941176470588	1.44106694156304	0.219254670003535	0.684781173139003
GO:0048038	quinone binding	6/4565	17/18639	0.352941176470588	1.44106694156304	0.219254670003535	0.684781173139003
GO:0070403	NAD+ binding	6/4565	17/18639	0.352941176470588	1.44106694156304	0.219254670003535	0.684781173139003
GO:1990226	histone methyltransferase binding	6/4565	17/18639	0.352941176470588	1.44106694156304	0.219254670003535	0.684781173139003
GO:0035613	RNA stem-loop binding	7/4565	21/18639	0.333333333333333	1.36100766703176	0.238520286489543	0.7431908690147
GO:0005347	ATP transmembrane transporter activity	5/4565	14/18639	0.357142857142857	1.45822250039118	0.243633681806306	0.750255122945588
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	5/4565	14/18639	0.357142857142857	1.45822250039118	0.243633681806306	0.750255122945588
GO:0032036	myosin heavy chain binding	5/4565	14/18639	0.357142857142857	1.45822250039118	0.243633681806306	0.750255122945588
GO:0061665	SUMO ligase activity	5/4565	14/18639	0.357142857142857	1.45822250039118	0.243633681806306	0.750255122945588
GO:1901612	cardiolipin binding	5/4565	14/18639	0.357142857142857	1.45822250039118	0.243633681806306	0.750255122945588
GO:0001784	phosphotyrosine residue binding	14/4565	47/18639	0.297872340425532	1.21621961734753	0.244843830225052	0.752224168383726
GO:0016782	transferase activity, transferring sulphur-containing groups	20/4565	70/18639	0.285714285714286	1.16657800031294	0.251702761754076	0.769787092300034
GO:0008139	nuclear localization sequence binding	8/4565	25/18639	0.32	1.30656736035049	0.253480726903046	0.769787092300034
GO:0019706	protein-cysteine S-palmitoyltransferase activity	8/4565	25/18639	0.32	1.30656736035049	0.253480726903046	0.769787092300034
GO:0019707	protein-cysteine S-acyltransferase activity	8/4565	25/18639	0.32	1.30656736035049	0.253480726903046	0.769787092300034
GO:0042974	nuclear retinoic acid receptor binding	8/4565	25/18639	0.32	1.30656736035049	0.253480726903046	0.769787092300034
GO:0050997	quaternary ammonium group binding	12/4565	40/18639	0.3	1.22490690032859	0.259325624243907	0.785726833916022
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	23/4565	82/18639	0.280487804878049	1.1452381588438	0.262700248917226	0.791606243982481
GO:0008525	phosphatidylcholine transporter activity	6/4565	18/18639	0.333333333333333	1.36100766703176	0.265142749608378	0.791606243982481
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	6/4565	18/18639	0.333333333333333	1.36100766703176	0.265142749608378	0.791606243982481
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	6/4565	18/18639	0.333333333333333	1.36100766703176	0.265142749608378	0.791606243982481
GO:1901611	phosphatidylglycerol binding	6/4565	18/18639	0.333333333333333	1.36100766703176	0.265142749608378	0.791606243982481
GO:0010484	histone H3 acetyltransferase activity	9/4565	29/18639	0.310344827586207	1.26714506930543	0.265470379241469	0.791606243982481
GO:0106222	lncRNA binding	9/4565	29/18639	0.310344827586207	1.26714506930543	0.265470379241469	0.791606243982481
GO:0005507	copper ion binding	18/4565	63/18639	0.285714285714286	1.16657800031294	0.266690451882655	0.793449245104604
GO:0002162	dystroglycan binding	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0005536	D-glucose binding	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0010854	adenylate cyclase regulator activity	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0015205	nucleobase transmembrane transporter activity	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0034056	estrogen response element binding	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0043522	leucine zipper domain binding	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0050786	RAGE receptor binding	4/4565	11/18639	0.363636363636364	1.48473563676192	0.272758212178649	0.795343636397034
GO:0008093	cytoskeletal anchor activity	7/4565	22/18639	0.318181818181818	1.29914368216668	0.280953658242879	0.812054652552883
GO:0031683	G-protein beta/gamma-subunit complex binding	7/4565	22/18639	0.318181818181818	1.29914368216668	0.280953658242879	0.812054652552883
GO:0061133	endopeptidase activator activity	7/4565	22/18639	0.318181818181818	1.29914368216668	0.280953658242879	0.812054652552883
GO:0140035	ubiquitin-like protein reader activity	7/4565	22/18639	0.318181818181818	1.29914368216668	0.280953658242879	0.812054652552883
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	23/4565	83/18639	0.27710843373494	1.13144010873725	0.284267907783576	0.819836110413028
GO:0070412	R-SMAD binding	8/4565	26/18639	0.307692307692308	1.25631476956778	0.293119114192608	0.841679722234982
GO:0097602	cullin family protein binding	8/4565	26/18639	0.307692307692308	1.25631476956778	0.293119114192608	0.841679722234982
GO:0004722	protein serine/threonine phosphatase activity	28/4565	103/18639	0.271844660194175	1.10994800029775	0.295920048195017	0.843046156799879
GO:0046915	transition metal ion transmembrane transporter activity	13/4565	45/18639	0.288888888888889	1.17953997809419	0.296549690163167	0.843046156799879
GO:0010181	FMN binding	5/4565	15/18639	0.333333333333333	1.36100766703176	0.29679318418448	0.843046156799879
GO:0016846	carbon-sulfur lyase activity	5/4565	15/18639	0.333333333333333	1.36100766703176	0.29679318418448	0.843046156799879
GO:0050780	dopamine receptor binding	5/4565	15/18639	0.333333333333333	1.36100766703176	0.29679318418448	0.843046156799879
GO:0019888	protein phosphatase regulator activity	29/4565	107/18639	0.271028037383178	1.10661371057723	0.297780694227867	0.844032161273824
GO:0001222	transcription corepressor binding	14/4565	49/18639	0.285714285714286	1.16657800031294	0.30177298276189	0.847303740537776
GO:0015215	nucleotide transmembrane transporter activity	9/4565	30/18639	0.3	1.22490690032859	0.302792156140586	0.847303740537776
GO:0031624	ubiquitin conjugating enzyme binding	9/4565	30/18639	0.3	1.22490690032859	0.302792156140586	0.847303740537776
GO:0043995	histone H4K5 acetyltransferase activity	9/4565	30/18639	0.3	1.22490690032859	0.302792156140586	0.847303740537776
GO:0043996	histone H4K8 acetyltransferase activity	9/4565	30/18639	0.3	1.22490690032859	0.302792156140586	0.847303740537776
GO:0043997	histone H4K12 acetyltransferase activity	9/4565	30/18639	0.3	1.22490690032859	0.302792156140586	0.847303740537776
GO:0016504	peptidase activator activity	16/4565	57/18639	0.280701754385965	1.1461117196057	0.310392595057119	0.864084316916593
GO:0019825	oxygen binding	10/4565	34/18639	0.294117647058824	1.2008891179692	0.310675756795067	0.864084316916593
GO:0052689	carboxylic ester hydrolase activity	25/4565	92/18639	0.271739130434783	1.10951711986285	0.310755664809154	0.864084316916593
GO:0005346	purine ribonucleotide transmembrane transporter activity	6/4565	19/18639	0.315789473684211	1.28937568455641	0.313124173217206	0.865194256394712
GO:0042800	histone H3K4 methyltransferase activity	6/4565	19/18639	0.315789473684211	1.28937568455641	0.313124173217206	0.865194256394712
GO:0140036	ubiquitin-modified protein reader activity	6/4565	19/18639	0.315789473684211	1.28937568455641	0.313124173217206	0.865194256394712
GO:0004721	phosphoprotein phosphatase activity	46/4565	175/18639	0.262857142857143	1.0732517602879	0.31648460397864	0.872650016828132
GO:0000295	adenine nucleotide transmembrane transporter activity	7/4565	23/18639	0.304347826086957	1.24265917424639	0.3250147214397	0.88444071660727
GO:0033192	calmodulin-dependent protein phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0140791	histone H2AXS140 phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0180004	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0180005	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0180006	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0180007	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0180008	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:1990439	MAP kinase serine/threonine phosphatase activity	22/4565	81/18639	0.271604938271605	1.10896921017403	0.327162495136207	0.88444071660727
GO:0030276	clathrin binding	13/4565	46/18639	0.282608695652174	1.15389780465736	0.327471221323481	0.88444071660727
GO:0004364	glutathione transferase activity	8/4565	27/18639	0.296296296296296	1.20978459291712	0.334081108682293	0.891533982054264
GO:0004300	enoyl-CoA hydratase activity	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0016801	hydrolase activity, acting on ether bonds	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0016803	ether hydrolase activity	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0031543	peptidyl-proline dioxygenase activity	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0034452	dynactin binding	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0045295	gamma-catenin binding	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	4/4565	12/18639	0.333333333333333	1.36100766703176	0.335508994763972	0.891533982054264
GO:0016878	acid-thiol ligase activity	9/4565	31/18639	0.290322580645161	1.18539377451154	0.341225387184456	0.904899517724574
GO:0051015	actin filament binding	54/4565	209/18639	0.258373205741627	1.05494374190979	0.349937243022688	0.919836893579663
GO:0033549	MAP kinase phosphatase activity	22/4565	82/18639	0.268292682926829	1.09544519541581	0.350798652083167	0.919836893579663
GO:0005521	lamin binding	5/4565	16/18639	0.3125	1.27594468784228	0.351534518053287	0.919836893579663
GO:0008142	oxysterol binding	5/4565	16/18639	0.3125	1.27594468784228	0.351534518053287	0.919836893579663
GO:0016722	oxidoreductase activity, acting on metal ions	5/4565	16/18639	0.3125	1.27594468784228	0.351534518053287	0.919836893579663
GO:0031435	mitogen-activated protein kinase kinase kinase binding	5/4565	16/18639	0.3125	1.27594468784228	0.351534518053287	0.919836893579663
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	11/4565	39/18639	0.282051282051282	1.1516218721038	0.351743394813468	0.919836893579663
GO:0008200	ion channel inhibitor activity	12/4565	43/18639	0.27906976744186	1.13944827937543	0.355710195782071	0.928368392159939
GO:0030544	Hsp70 protein binding	14/4565	51/18639	0.274509803921569	1.12082984343792	0.361927487556623	0.938131524432687
GO:0016408	C-acyltransferase activity	6/4565	20/18639	0.3	1.22490690032859	0.362298138039634	0.938131524432687
GO:0031418	L-ascorbic acid binding	6/4565	20/18639	0.3	1.22490690032859	0.362298138039634	0.938131524432687
GO:0052745	inositol phosphate phosphatase activity	6/4565	20/18639	0.3	1.22490690032859	0.362298138039634	0.938131524432687
GO:0036408	histone H3K14 acetyltransferase activity	8/4565	28/18639	0.285714285714286	1.16657800031294	0.375840356691423	0.969388630370441
GO:0046625	sphingolipid binding	8/4565	28/18639	0.285714285714286	1.16657800031294	0.375840356691423	0.969388630370441
GO:0005484	SNAP receptor activity	10/4565	36/18639	0.277777777777778	1.1341730558598	0.38391570534852	0.988283007127635
GO:0071949	FAD binding	11/4565	40/18639	0.275	1.1228313253012	0.386798411236404	0.993762779745771
GO:0016248	channel inhibitor activity	12/4565	44/18639	0.272727272727273	1.11355172757144	0.389155363409284	0.997873091388007
GO:0140693	molecular condensate scaffold activity	13/4565	48/18639	0.270833333333333	1.10581872946331	0.391101596548427	1
GO:0048306	calcium-dependent protein binding	21/4565	80/18639	0.2625	1.07179353778751	0.39866741829441	1
GO:0002161	aminoacyl-tRNA editing activity	4/4565	13/18639	0.307692307692308	1.25631476956778	0.39868986180967	1
GO:0003964	RNA-directed DNA polymerase activity	4/4565	13/18639	0.307692307692308	1.25631476956778	0.39868986180967	1
GO:0031994	insulin-like growth factor I binding	4/4565	13/18639	0.307692307692308	1.25631476956778	0.39868986180967	1
GO:0043560	insulin receptor substrate binding	4/4565	13/18639	0.307692307692308	1.25631476956778	0.39868986180967	1
GO:0051011	microtubule minus-end binding	4/4565	13/18639	0.307692307692308	1.25631476956778	0.39868986180967	1
GO:0061459	L-arginine transmembrane transporter activity	4/4565	13/18639	0.307692307692308	1.25631476956778	0.39868986180967	1
GO:0017018	myosin phosphatase activity	22/4565	84/18639	0.261904761904762	1.06936316695353	0.399050977944111	1
GO:0140789	histone phosphatase activity	35/4565	136/18639	0.257352941176471	1.05077797822305	0.399701618151574	1
GO:0016791	phosphatase activity	69/4565	273/18639	0.252747252747253	1.03197284643068	0.40392215747418	1
GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	5/4565	17/18639	0.294117647058824	1.2008891179692	0.406651121407351	1
GO:0005092	GDP-dissociation inhibitor activity	5/4565	17/18639	0.294117647058824	1.2008891179692	0.406651121407351	1
GO:0017110	nucleoside diphosphate phosphatase activity	5/4565	17/18639	0.294117647058824	1.2008891179692	0.406651121407351	1
GO:0031489	myosin V binding	5/4565	17/18639	0.294117647058824	1.2008891179692	0.406651121407351	1
GO:0015174	basic amino acid transmembrane transporter activity	6/4565	21/18639	0.285714285714286	1.16657800031294	0.411809278659671	1
GO:0051010	microtubule plus-end binding	6/4565	21/18639	0.285714285714286	1.16657800031294	0.411809278659671	1
GO:1901981	phosphatidylinositol phosphate binding	47/4565	185/18639	0.254054054054054	1.03730854622421	0.413643535789189	1
GO:0000030	mannosyltransferase activity	7/4565	25/18639	0.28	1.14324644030668	0.415356317295301	1
GO:0047617	fatty acyl-CoA hydrolase activity	7/4565	25/18639	0.28	1.14324644030668	0.415356317295301	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	7/4565	25/18639	0.28	1.14324644030668	0.415356317295301	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	8/4565	29/18639	0.275862068965517	1.12635117271594	0.417886062386644	1
GO:0097472	cyclin-dependent protein kinase activity	8/4565	29/18639	0.275862068965517	1.12635117271594	0.417886062386644	1
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	11/4565	41/18639	0.268292682926829	1.09544519541581	0.422094051192685	1
GO:0141110	transporter inhibitor activity	12/4565	45/18639	0.266666666666667	1.08880613362541	0.422830153680599	1
GO:0004864	protein phosphatase inhibitor activity	14/4565	53/18639	0.264150943396226	1.07853437764781	0.423725097936077	1
GO:0048029	monosaccharide binding	19/4565	74/18639	0.256756756756757	1.04834374352447	0.450452403182078	1
GO:0097110	scaffold protein binding	18/4565	70/18639	0.257142857142857	1.04992020028165	0.451297248673777	1
GO:0005109	frizzled binding	10/4565	38/18639	0.263157894736842	1.07447973713034	0.45818419448997	1
GO:0003680	minor groove of adenine-thymine-rich DNA binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0005337	nucleoside transmembrane transporter activity	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0005381	iron ion transmembrane transporter activity	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0005528	FK506 binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0008190	eukaryotic initiation factor 4E binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0015643	toxic substance binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0030957	Tat protein binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0031078	histone H3K14 deacetylase activity, hydrolytic mechanism	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0031419	cobalamin binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0034739	histone H4K16 deacetylase activity, hydrolytic mechanism	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0035374	chondroitin sulfate binding	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0180032	histone H4K5 deacetylase activity, hydrolytic mechanism	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0180033	histone H4K8 deacetylase activity, hydrolytic mechanism	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:1990162	histone H3K4 deacetylase activity, hydrolytic mechanism	3/4565	10/18639	0.3	1.22490690032859	0.459107353783113	1
GO:0031210	phosphatidylcholine binding	8/4565	30/18639	0.266666666666667	1.08880613362541	0.459738391930665	1
GO:0015216	purine nucleotide transmembrane transporter activity	7/4565	26/18639	0.269230769230769	1.09927542337181	0.460391076333136	1
GO:0016289	acyl-CoA hydrolase activity	7/4565	26/18639	0.269230769230769	1.09927542337181	0.460391076333136	1
GO:0050750	low-density lipoprotein particle receptor binding	7/4565	26/18639	0.269230769230769	1.09927542337181	0.460391076333136	1
GO:0120014	phospholipid transfer activity	7/4565	26/18639	0.269230769230769	1.09927542337181	0.460391076333136	1
GO:0019783	ubiquitin-like protein peptidase activity	32/4565	127/18639	0.251968503937008	1.02879319712637	0.460504774096199	1
GO:0004705	JUN kinase activity	4/4565	14/18639	0.285714285714286	1.16657800031294	0.460712333811015	1
GO:0008494	translation activator activity	4/4565	14/18639	0.285714285714286	1.16657800031294	0.460712333811015	1
GO:0042813	Wnt receptor activity	4/4565	14/18639	0.285714285714286	1.16657800031294	0.460712333811015	1
GO:0052816	long-chain fatty acyl-CoA hydrolase activity	4/4565	14/18639	0.285714285714286	1.16657800031294	0.460712333811015	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0032931	histone H3K56 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0043992	histone H3K9 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0043993	histone H3K18 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0043994	histone H3K23 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0043999	histone H2AK5 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0044012	histone H2AK9 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0044014	histone H2BK5 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0044015	histone H2BK12 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0044016	histone H3K4 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0044017	histone H3K27 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0044018	histone H3K36 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0046972	histone H4K16 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0140908	histone H3K122 acetyltransferase activity	6/4565	22/18639	0.272727272727273	1.11355172757144	0.460880136315968	1
GO:0000900	mRNA regulatory element binding translation repressor activity	5/4565	18/18639	0.277777777777778	1.1341730558598	0.461077418253109	1
GO:0016854	racemase and epimerase activity	5/4565	18/18639	0.277777777777778	1.1341730558598	0.461077418253109	1
GO:0031690	adrenergic receptor binding	5/4565	18/18639	0.277777777777778	1.1341730558598	0.461077418253109	1
GO:1990381	ubiquitin-specific protease binding	5/4565	18/18639	0.277777777777778	1.1341730558598	0.461077418253109	1
GO:0072341	modified amino acid binding	23/4565	91/18639	0.252747252747253	1.03197284643068	0.471087535997552	1
GO:0140313	molecular sequestering activity	14/4565	55/18639	0.254545454545455	1.03931494573335	0.48559991422997	1
GO:0016597	amino acid binding	13/4565	51/18639	0.254901960784314	1.04077056890664	0.487670295536069	1
GO:0043495	protein-membrane adaptor activity	12/4565	47/18639	0.25531914893617	1.04247395772646	0.489888144638384	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	11/4565	43/18639	0.255813953488372	1.04449425609414	0.492281635658148	1
GO:0003779	actin binding	109/4565	443/18639	0.246049661399549	1.00462642690606	0.496294886861517	1
GO:0004197	cysteine-type endopeptidase activity	22/4565	88/18639	0.25	1.02075575027382	0.496806801004466	1
GO:0005154	epidermal growth factor receptor binding	9/4565	35/18639	0.257142857142857	1.04992020028165	0.49775732336556	1
GO:0035591	signaling adaptor activity	32/4565	129/18639	0.248062015503876	1.01284291500038	0.500813699992409	1
GO:0017147	Wnt-protein binding	8/4565	31/18639	0.258064516129032	1.05368335512137	0.500960306624998	1
GO:0030145	manganese ion binding	17/4565	68/18639	0.25	1.02075575027382	0.507779991679749	1
GO:0044013	histone H2B acetyltransferase activity	6/4565	23/18639	0.260869565217391	1.06513643506834	0.508832635684062	1
GO:0003756	protein disulfide isomerase activity	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0005520	insulin-like growth factor binding	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0046527	glucosyltransferase activity	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0046624	sphingolipid transporter activity	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0070003	threonine-type peptidase activity	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0097001	ceramide binding	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0120227	acyl-CoA binding	5/4565	19/18639	0.263157894736842	1.07447973713034	0.513917862908788	1
GO:0004698	calcium,diacylglycerol-dependent serine/threonine kinase activity	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0004699	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0005523	tropomyosin binding	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0045504	dynein heavy chain binding	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0120283	protein serine/threonine kinase binding	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0140161	monocarboxylate:sodium symporter activity	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0141050	histone H3K deacetylase activity	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0141051	histone H4K deacetylase activity	4/4565	15/18639	0.266666666666667	1.08880613362541	0.520319297311574	1
GO:0008526	phosphatidylinositol transfer activity	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0019107	myristoyltransferase activity	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0019215	intermediate filament binding	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0032129	histone H3K9 deacetylase activity, hydrolytic mechanism	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0035252	UDP-xylosyltransferase activity	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0042285	xylosyltransferase activity	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0048185	activin binding	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0140031	phosphorylation-dependent protein binding	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0140537	transcription regulator activator activity	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0140937	histone H4K12 deacetylase activity, hydrolytic mechanism	3/4565	11/18639	0.272727272727273	1.11355172757144	0.528988281884786	1
GO:0004725	protein tyrosine phosphatase activity	24/4565	98/18639	0.244897959183673	0.999924000268234	0.53918378039793	1
GO:0046906	tetrapyrrole binding	37/4565	152/18639	0.243421052631579	0.993893756845564	0.548562738896864	1
GO:1902936	phosphatidylinositol bisphosphate binding	27/4565	111/18639	0.243243243243243	0.993167757023179	0.55304816558327	1
GO:0030742	GTP-dependent protein binding	5/4565	20/18639	0.25	1.02075575027382	0.564457771198507	1
GO:0004674	protein serine/threonine kinase activity	105/4565	433/18639	0.242494226327945	0.990109503729805	0.565995458806126	1
GO:0017080	sodium channel regulator activity	10/4565	41/18639	0.24390243902439	0.995859268559827	0.566022174625894	1
GO:0042169	SH2 domain binding	10/4565	41/18639	0.24390243902439	0.995859268559827	0.566022174625894	1
GO:0000062	fatty-acyl-CoA binding	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0004697	diacylglycerol-dependent serine/threonine kinase activity	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0004707	MAP kinase activity	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0004708	MAP kinase kinase activity	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0005324	long-chain fatty acid transmembrane transporter activity	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0070411	I-SMAD binding	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	4/4565	16/18639	0.25	1.02075575027382	0.576580890397668	1
GO:0140311	protein sequestering activity	8/4565	33/18639	0.242424242424242	0.989823757841283	0.580025269190229	1
GO:0140416	transcription regulator inhibitor activity	8/4565	33/18639	0.242424242424242	0.989823757841283	0.580025269190229	1
GO:0003785	actin monomer binding	7/4565	29/18639	0.241379310344828	0.985557276126449	0.588766240713592	1
GO:0043236	laminin binding	7/4565	29/18639	0.241379310344828	0.985557276126449	0.588766240713592	1
GO:0020037	heme binding	34/4565	142/18639	0.23943661971831	0.977625225614365	0.592790920315411	1
GO:0003720	telomerase activity	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0005527	macrolide binding	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0008179	adenylate cyclase binding	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0010853	cyclase activator activity	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0016208	AMP binding	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0016840	carbon-nitrogen lyase activity	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0141221	histone deacetylase activity, hydrolytic mechanism	3/4565	12/18639	0.25	1.02075575027382	0.593481377591724	1
GO:0005085	guanyl-nucleotide exchange factor activity	55/4565	230/18639	0.239130434782609	0.976375065479309	0.606622140845401	1
GO:0035402	histone H3T11 kinase activity	59/4565	247/18639	0.238866396761134	0.975296992164462	0.612432501812354	1
GO:0030295	protein kinase activator activity	33/4565	139/18639	0.237410071942446	0.969350784432695	0.614172056799029	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	8/4565	34/18639	0.235294117647059	0.960711294375363	0.617266932784671	1
GO:0019209	kinase activator activity	35/4565	148/18639	0.236486486486486	0.965579763772535	0.625831148188405	1
GO:0046965	nuclear retinoid X receptor binding	4/4565	17/18639	0.235294117647059	0.960711294375363	0.62886697316392	1
GO:1901567	fatty acid derivative binding	4/4565	17/18639	0.235294117647059	0.960711294375363	0.62886697316392	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	14/4565	60/18639	0.233333333333333	0.952705366922235	0.631677003670242	1
GO:0106310	protein serine kinase activity	86/4565	361/18639	0.238227146814404	0.972686919928518	0.637335915474887	1
GO:0030507	spectrin binding	6/4565	26/18639	0.230769230769231	0.942236077175836	0.640880788936731	1
GO:0034237	protein kinase A regulatory subunit binding	6/4565	26/18639	0.230769230769231	0.942236077175836	0.640880788936731	1
GO:0050681	nuclear androgen receptor binding	6/4565	26/18639	0.230769230769231	0.942236077175836	0.640880788936731	1
GO:0070006	metalloaminopeptidase activity	6/4565	26/18639	0.230769230769231	0.942236077175836	0.640880788936731	1
GO:0004676	3-phosphoinositide-dependent protein kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0004711	ribosomal protein S6 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0035175	histone H3S10 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0035979	histone H2AXS139 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0044022	histone H3S28 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0044023	histone H4S1 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0044024	histone H2AS1 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0044025	histone H2BS14 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0072354	histone H3T3 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0072371	histone H2AS121 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0072518	Rho-dependent protein serine/threonine kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0140823	histone H2BS36 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0140855	histone H3S57 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0140995	histone H2A kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0140997	histone H4 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0140998	histone H2B kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:1990244	histone H2AT120 kinase activity	58/4565	245/18639	0.236734693877551	0.966593200259293	0.641969668241867	1
GO:0005172	vascular endothelial growth factor receptor binding	3/4565	13/18639	0.230769230769231	0.942236077175836	0.651918832326341	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3/4565	13/18639	0.230769230769231	0.942236077175836	0.651918832326341	1
GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	3/4565	13/18639	0.230769230769231	0.942236077175836	0.651918832326341	1
GO:0070700	BMP receptor binding	3/4565	13/18639	0.230769230769231	0.942236077175836	0.651918832326341	1
GO:0140410	monoatomic cation:bicarbonate symporter activity	3/4565	13/18639	0.230769230769231	0.942236077175836	0.651918832326341	1
GO:0004677	DNA-dependent protein kinase activity	58/4565	246/18639	0.235772357723577	0.962663959607833	0.65538299262052	1
GO:0140857	histone H3T45 kinase activity	58/4565	246/18639	0.235772357723577	0.962663959607833	0.65538299262052	1
GO:0016881	acid-amino acid ligase activity	5/4565	22/18639	0.227272727272727	0.927959772976202	0.6566546277054	1
GO:0140784	metal ion sensor activity	5/4565	22/18639	0.227272727272727	0.927959772976202	0.6566546277054	1
GO:0005200	structural constituent of cytoskeleton	26/4565	112/18639	0.232142857142857	0.947844625254264	0.659051965746452	1
GO:0005310	dicarboxylic acid transmembrane transporter activity	7/4565	31/18639	0.225806451612903	0.921972935731195	0.665099209145039	1
GO:0070325	lipoprotein particle receptor binding	7/4565	31/18639	0.225806451612903	0.921972935731195	0.665099209145039	1
GO:0072349	modified amino acid transmembrane transporter activity	7/4565	31/18639	0.225806451612903	0.921972935731195	0.665099209145039	1
GO:0035403	histone H3T6 kinase activity	58/4565	247/18639	0.234817813765182	0.958766534670149	0.668563566519323	1
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	57/4565	243/18639	0.234567901234568	0.957746136059389	0.670971265382325	1
GO:0030331	nuclear estrogen receptor binding	9/4565	40/18639	0.225	0.91868017524644	0.674224846919333	1
GO:0008308	voltage-gated monoatomic anion channel activity	4/4565	18/18639	0.222222222222222	0.907338444687842	0.67680684599558	1
GO:0034185	apolipoprotein binding	4/4565	18/18639	0.222222222222222	0.907338444687842	0.67680684599558	1
GO:0004683	calcium/calmodulin-dependent protein kinase activity	6/4565	27/18639	0.222222222222222	0.907338444687842	0.679818281486959	1
GO:0016405	CoA-ligase activity	6/4565	27/18639	0.222222222222222	0.907338444687842	0.679818281486959	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	6/4565	27/18639	0.222222222222222	0.907338444687842	0.679818281486959	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	6/4565	27/18639	0.222222222222222	0.907338444687842	0.679818281486959	1
GO:0004679	AMP-activated protein kinase activity	58/4565	248/18639	0.233870967741935	0.954900540578737	0.681499405425387	1
GO:0003950	NAD+ poly-ADP-ribosyltransferase activity	5/4565	23/18639	0.217391304347826	0.88761369589028	0.697716292155772	1
GO:0140103	catalytic activity, acting on a glycoprotein	5/4565	23/18639	0.217391304347826	0.88761369589028	0.697716292155772	1
GO:1990404	NAD+-protein mono-ADP-ribosyltransferase activity	5/4565	23/18639	0.217391304347826	0.88761369589028	0.697716292155772	1
GO:0008378	galactosyltransferase activity	7/4565	32/18639	0.21875	0.893161281489595	0.69980054418985	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/4565	32/18639	0.21875	0.893161281489595	0.69980054418985	1
GO:0043425	bHLH transcription factor binding	7/4565	32/18639	0.21875	0.893161281489595	0.69980054418985	1
GO:0030283	testosterone dehydrogenase [NAD(P)+] activity	3/4565	14/18639	0.214285714285714	0.874933500234705	0.704066059194157	1
GO:0034236	protein kinase A catalytic subunit binding	3/4565	14/18639	0.214285714285714	0.874933500234705	0.704066059194157	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	3/4565	14/18639	0.214285714285714	0.874933500234705	0.704066059194157	1
GO:0046030	inositol trisphosphate phosphatase activity	3/4565	14/18639	0.214285714285714	0.874933500234705	0.704066059194157	1
GO:0017022	myosin binding	17/4565	76/18639	0.223684210526316	0.913307776560789	0.708460596277669	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	20/4565	89/18639	0.224719101123595	0.917533258673099	0.709867185253138	1
GO:0030946	protein tyrosine phosphatase activity, metal-dependent	20/4565	89/18639	0.224719101123595	0.917533258673099	0.709867185253138	1
GO:0035091	phosphatidylinositol binding	66/4565	284/18639	0.232394366197183	0.94887154250806	0.710912956381951	1
GO:0017124	SH3 domain binding	26/4565	115/18639	0.226086956521739	0.923118243725892	0.714714182465914	1
GO:0101005	deubiquitinase activity	26/4565	115/18639	0.226086956521739	0.923118243725892	0.714714182465914	1
GO:0046875	ephrin receptor binding	6/4565	28/18639	0.214285714285714	0.874933500234705	0.715899821587739	1
GO:0015245	fatty acid transmembrane transporter activity	4/4565	19/18639	0.210526315789474	0.859583789704272	0.720243908152058	1
GO:0005548	phospholipid transporter activity	15/4565	68/18639	0.220588235294118	0.900666838476902	0.72335441380714	1
GO:0008374	O-acyltransferase activity	12/4565	55/18639	0.218181818181818	0.890841382057154	0.726206805225598	1
GO:0140793	histone H2AXY142 phosphatase activity	20/4565	90/18639	0.222222222222222	0.907338444687842	0.729587952180742	1
GO:0005540	hyaluronic acid binding	5/4565	24/18639	0.208333333333333	0.850629791894852	0.735246948797573	1
GO:0070300	phosphatidic acid binding	5/4565	24/18639	0.208333333333333	0.850629791894852	0.735246948797573	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	13/4565	60/18639	0.216666666666667	0.884654983570646	0.740492127076282	1
GO:0004090	carbonyl reductase (NADPH) activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0004445	inositol-polyphosphate 5-phosphatase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0004862	cAMP-dependent protein kinase inhibitor activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0008140	cAMP response element binding protein binding	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0008519	ammonium channel activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0015187	glycine transmembrane transporter activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0019911	structural constituent of myelin sheath	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0031434	mitogen-activated protein kinase kinase binding	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0031956	medium-chain fatty acid-CoA ligase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0042975	peroxisome proliferator activated receptor binding	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0070097	delta-catenin binding	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0140999	histone H3K4 trimethyltransferase activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0141109	transporter activator activity	2/4565	10/18639	0.2	0.816604600219058	0.744404704124134	1
GO:0000146	microfilament motor activity	8/4565	38/18639	0.210526315789474	0.859583789704272	0.74659267898517	1
GO:0042887	amide transmembrane transporter activity	8/4565	38/18639	0.210526315789474	0.859583789704272	0.74659267898517	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	6/4565	29/18639	0.206896551724138	0.844763379536957	0.749065103554908	1
GO:0051861	glycolipid binding	6/4565	29/18639	0.206896551724138	0.844763379536957	0.749065103554908	1
GO:0004467	long-chain fatty acid-CoA ligase activity	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0005041	low-density lipoprotein particle receptor activity	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0008242	omega peptidase activity	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0031005	filamin binding	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0033130	acetylcholine receptor binding	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0048531	beta-1,3-galactosyltransferase activity	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0051371	muscle alpha-actinin binding	3/4565	15/18639	0.2	0.816604600219058	0.750002749664803	1
GO:0010851	cyclase regulator activity	4/4565	20/18639	0.2	0.816604600219058	0.759190442390445	1
GO:0015095	magnesium ion transmembrane transporter activity	4/4565	20/18639	0.2	0.816604600219058	0.759190442390445	1
GO:0016004	phospholipase activator activity	4/4565	20/18639	0.2	0.816604600219058	0.759190442390445	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	4/4565	20/18639	0.2	0.816604600219058	0.759190442390445	1
GO:0048156	tau protein binding	9/4565	43/18639	0.209302325581395	0.854586209531572	0.759828967680928	1
GO:0015297	antiporter activity	30/4565	135/18639	0.222222222222222	0.907338444687842	0.76033449469664	1
GO:0030159	signaling receptor complex adaptor activity	11/4565	52/18639	0.211538461538462	0.86371640407785	0.760550265357922	1
GO:0015645	fatty acid ligase activity	5/4565	25/18639	0.2	0.816604600219058	0.769251356797607	1
GO:0019211	phosphatase activator activity	5/4565	25/18639	0.2	0.816604600219058	0.769251356797607	1
GO:0120515	fatty acid-CoA ligase activity	5/4565	25/18639	0.2	0.816604600219058	0.769251356797607	1
GO:0044325	transmembrane transporter binding	30/4565	136/18639	0.220588235294118	0.900666838476902	0.774882251732085	1
GO:0001965	G-protein alpha-subunit binding	6/4565	30/18639	0.2	0.816604600219058	0.779322482944797	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	6/4565	30/18639	0.2	0.816604600219058	0.779322482944797	1
GO:0033612	receptor serine/threonine kinase binding	6/4565	30/18639	0.2	0.816604600219058	0.779322482944797	1
GO:0005246	calcium channel regulator activity	11/4565	53/18639	0.207547169811321	0.847419868151853	0.783170711730448	1
GO:0051018	protein kinase A binding	11/4565	53/18639	0.207547169811321	0.847419868151853	0.783170711730448	1
GO:0051213	dioxygenase activity	20/4565	93/18639	0.21505376344086	0.878069462601138	0.783602986941652	1
GO:0016229	steroid dehydrogenase activity	7/4565	35/18639	0.2	0.816604600219058	0.789087851909052	1
GO:0005159	insulin-like growth factor receptor binding	3/4565	16/18639	0.1875	0.765566812705367	0.79002317872645	1
GO:0015378	sodium:chloride symporter activity	3/4565	16/18639	0.1875	0.765566812705367	0.79002317872645	1
GO:0055102	lipase inhibitor activity	3/4565	16/18639	0.1875	0.765566812705367	0.79002317872645	1
GO:0140328	floppase activity	3/4565	16/18639	0.1875	0.765566812705367	0.79002317872645	1
GO:0004016	adenylate cyclase activity	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0008046	axon guidance receptor activity	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0008199	ferric iron binding	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0008432	JUN kinase binding	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0032050	clathrin heavy chain binding	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0034713	type I transforming growth factor beta receptor binding	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0047676	arachidonate-CoA ligase activity	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0050998	nitric-oxide synthase binding	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0180030	inositol phosphate kinase activity	2/4565	11/18639	0.181818181818182	0.742367818380962	0.792275020177323	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	4/4565	21/18639	0.19047619047619	0.777718666875293	0.793785740572458	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	4/4565	21/18639	0.19047619047619	0.777718666875293	0.793785740572458	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/4565	21/18639	0.19047619047619	0.777718666875293	0.793785740572458	1
GO:0051428	peptide hormone receptor binding	4/4565	21/18639	0.19047619047619	0.777718666875293	0.793785740572458	1
GO:0061891	calcium ion sensor activity	4/4565	21/18639	0.19047619047619	0.777718666875293	0.793785740572458	1
GO:0072542	protein phosphatase activator activity	4/4565	21/18639	0.19047619047619	0.777718666875293	0.793785740572458	1
GO:0004177	aminopeptidase activity	8/4565	40/18639	0.2	0.816604600219058	0.798430420198569	1
GO:0032451	demethylase activity	8/4565	40/18639	0.2	0.816604600219058	0.798430420198569	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	5/4565	26/18639	0.192307692307692	0.785196730979864	0.799815777716864	1
GO:0052742	phosphatidylinositol kinase activity	5/4565	26/18639	0.192307692307692	0.785196730979864	0.799815777716864	1
GO:0001618	virus receptor activity	17/4565	81/18639	0.209876543209877	0.856930753316295	0.804789358489506	1
GO:0030971	receptor tyrosine kinase binding	17/4565	81/18639	0.209876543209877	0.856930753316295	0.804789358489506	1
GO:0005164	tumor necrosis factor receptor binding	6/4565	31/18639	0.193548387096774	0.790262516341024	0.806736068656739	1
GO:0004879	nuclear receptor activity	12/4565	59/18639	0.203389830508475	0.830445356154974	0.813127556347145	1
GO:0060589	nucleoside-triphosphatase regulator activity	112/4565	490/18639	0.228571428571429	0.933262400250352	0.817098980921164	1
GO:0042578	phosphoric ester hydrolase activity	82/4565	363/18639	0.225895316804408	0.922335774352104	0.8188662414787	1
GO:0140272	exogenous protein binding	17/4565	82/18639	0.207317073170732	0.846480378275853	0.820988774504931	1
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	26/4565	122/18639	0.213114754098361	0.870152442856373	0.821927070569165	1
GO:0098531	ligand-modulated transcription factor activity	12/4565	60/18639	0.2	0.816604600219058	0.831286413664861	1
GO:0046982	protein heterodimerization activity	83/4565	369/18639	0.224932249322493	0.91840354767184	0.832014877035756	1
GO:0004032	aldose reductase (NADPH) activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0004126	cytidine deaminase activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0004859	phospholipase inhibitor activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0005025	transforming growth factor beta receptor activity, type I	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0005026	transforming growth factor beta receptor activity, type II	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0005078	MAP-kinase scaffold activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0008504	monoamine transmembrane transporter activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0008603	cAMP-dependent protein kinase regulator activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0015132	prostaglandin transmembrane transporter activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0016361	activin receptor activity, type I	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0016362	activin receptor activity, type II	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0017002	activin receptor activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0035251	UDP-glucosyltransferase activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0042301	phosphate ion binding	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0097677	STAT family protein binding	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:1990459	transferrin receptor binding	2/4565	12/18639	0.166666666666667	0.680503833515882	0.832033748694442	1
GO:0004857	enzyme inhibitor activity	94/4565	416/18639	0.225961538461538	0.92260615890134	0.833065376956841	1
GO:0042805	actinin binding	7/4565	37/18639	0.189189189189189	0.772463811018028	0.836469886027198	1
GO:0030695	GTPase regulator activity	111/4565	489/18639	0.226993865030675	0.926821172027765	0.838206076760197	1
GO:0046332	SMAD binding	16/4565	79/18639	0.20253164556962	0.826941367310439	0.843771537960366	1
GO:0005158	insulin receptor binding	4/4565	23/18639	0.173913043478261	0.710090956712224	0.85089995890512	1
GO:0031681	G-protein beta-subunit binding	4/4565	23/18639	0.173913043478261	0.710090956712224	0.85089995890512	1
GO:0042171	lysophosphatidic acid acyltransferase activity	4/4565	23/18639	0.173913043478261	0.710090956712224	0.85089995890512	1
GO:0043274	phospholipase binding	4/4565	23/18639	0.173913043478261	0.710090956712224	0.85089995890512	1
GO:0071617	lysophospholipid acyltransferase activity	4/4565	23/18639	0.173913043478261	0.710090956712224	0.85089995890512	1
GO:0051393	alpha-actinin binding	5/4565	28/18639	0.178571428571429	0.729111250195588	0.851259265160323	1
GO:0033218	amide binding	54/4565	247/18639	0.218623481781377	0.892644704692897	0.851564172994882	1
GO:0005080	protein kinase C binding	10/4565	52/18639	0.192307692307692	0.785196730979864	0.852854598338416	1
GO:0071889	14-3-3 protein binding	6/4565	33/18639	0.181818181818182	0.742367818380962	0.853494778216988	1
GO:0015172	acidic amino acid transmembrane transporter activity	3/4565	18/18639	0.166666666666667	0.680503833515882	0.854106612417274	1
GO:0015373	monoatomic anion:sodium symporter activity	3/4565	18/18639	0.166666666666667	0.680503833515882	0.854106612417274	1
GO:0017128	phospholipid scramblase activity	3/4565	18/18639	0.166666666666667	0.680503833515882	0.854106612417274	1
GO:0030228	lipoprotein particle receptor activity	3/4565	18/18639	0.166666666666667	0.680503833515882	0.854106612417274	1
GO:0008234	cysteine-type peptidase activity	40/4565	187/18639	0.213903743315508	0.873373903977602	0.859788988956574	1
GO:0008417	fucosyltransferase activity	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0017154	semaphorin receptor activity	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0030955	potassium ion binding	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0031432	titin binding	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0035673	oligopeptide transmembrane transporter activity	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0039706	co-receptor binding	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0070123	transforming growth factor beta receptor activity, type III	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0071714	icosanoid transmembrane transporter activity	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0071837	HMG box domain binding	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0089720	caspase binding	2/4565	13/18639	0.153846153846154	0.628157384783891	0.864781915306824	1
GO:0003730	mRNA 3'-UTR binding	57/4565	262/18639	0.217557251908397	0.888291263597067	0.867064980895707	1
GO:0004843	cysteine-type deubiquitinase activity	22/4565	108/18639	0.203703703703704	0.831726907630522	0.867899535200821	1
GO:1990782	protein tyrosine kinase binding	24/4565	117/18639	0.205128205128205	0.837543179711854	0.868005320341279	1
GO:0005003	ephrin receptor activity	10/4565	53/18639	0.188679245283019	0.770381698319866	0.869060153363525	1
GO:0005005	transmembrane-ephrin receptor activity	10/4565	53/18639	0.188679245283019	0.770381698319866	0.869060153363525	1
GO:0035250	UDP-galactosyltransferase activity	5/4565	29/18639	0.172413793103448	0.703969482947464	0.872549715494784	1
GO:0008376	acetylgalactosaminyltransferase activity	6/4565	34/18639	0.176470588235294	0.720533470781522	0.873142433760761	1
GO:0090482	vitamin transmembrane transporter activity	6/4565	34/18639	0.176470588235294	0.720533470781522	0.873142433760761	1
GO:0005315	phosphate transmembrane transporter activity	4/4565	24/18639	0.166666666666667	0.680503833515882	0.87403056092663	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4/4565	24/18639	0.166666666666667	0.680503833515882	0.87403056092663	1
GO:0030215	semaphorin receptor binding	4/4565	24/18639	0.166666666666667	0.680503833515882	0.87403056092663	1
GO:0035035	histone acetyltransferase binding	4/4565	24/18639	0.166666666666667	0.680503833515882	0.87403056092663	1
GO:0060229	lipase activator activity	4/4565	24/18639	0.166666666666667	0.680503833515882	0.87403056092663	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	4/4565	24/18639	0.166666666666667	0.680503833515882	0.87403056092663	1
GO:0043014	alpha-tubulin binding	8/4565	44/18639	0.181818181818182	0.742367818380962	0.877517195546096	1
GO:1901682	sulfur compound transmembrane transporter activity	12/4565	63/18639	0.19047619047619	0.777718666875293	0.877721566758644	1
GO:0030506	ankyrin binding	3/4565	19/18639	0.157894736842105	0.644687842278204	0.879205869467003	1
GO:0031420	alkali metal ion binding	3/4565	19/18639	0.157894736842105	0.644687842278204	0.879205869467003	1
GO:1990380	K48-linked deubiquitinase activity	3/4565	19/18639	0.157894736842105	0.644687842278204	0.879205869467003	1
GO:0015485	cholesterol binding	10/4565	54/18639	0.185185185185185	0.756115370573202	0.88379649884783	1
GO:0035173	histone kinase activity	79/4565	360/18639	0.219444444444444	0.895996714129244	0.885234487690004	1
GO:0070888	E-box binding	11/4565	59/18639	0.186440677966102	0.761241576475393	0.887214418218722	1
GO:0019199	transmembrane receptor protein kinase activity	15/4565	78/18639	0.192307692307692	0.785196730979864	0.890202621639628	1
GO:0005343	organic acid:sodium symporter activity	6/4565	35/18639	0.171428571428571	0.699946800187764	0.890533036902493	1
GO:0001968	fibronectin binding	5/4565	30/18639	0.166666666666667	0.680503833515882	0.891195162004781	1
GO:0004065	arylsulfatase activity	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0005313	L-glutamate transmembrane transporter activity	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0008559	ABC-type xenobiotic transporter activity	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0015926	glucosidase activity	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0031404	chloride ion binding	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0044548	S100 protein binding	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0071933	Arp2/3 complex binding	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0098821	BMP receptor activity	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:1901474	azole transmembrane transporter activity	2/4565	14/18639	0.142857142857143	0.58328900015647	0.891567891325602	1
GO:0003707	nuclear steroid receptor activity	4/4565	25/18639	0.16	0.653283680175247	0.893988504570253	1
GO:0015296	monoatomic anion:monoatomic cation symporter activity	4/4565	25/18639	0.16	0.653283680175247	0.893988504570253	1
GO:0015662	P-type ion transporter activity	4/4565	25/18639	0.16	0.653283680175247	0.893988504570253	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	4/4565	25/18639	0.16	0.653283680175247	0.893988504570253	1
GO:0140358	P-type transmembrane transporter activity	4/4565	25/18639	0.16	0.653283680175247	0.893988504570253	1
GO:0005006	epidermal growth factor receptor activity	9/4565	50/18639	0.18	0.734944140197152	0.894745024722039	1
GO:0005007	fibroblast growth factor receptor activity	9/4565	50/18639	0.18	0.734944140197152	0.894745024722039	1
GO:0005017	platelet-derived growth factor receptor activity	9/4565	50/18639	0.18	0.734944140197152	0.894745024722039	1
GO:0005019	platelet-derived growth factor beta-receptor activity	9/4565	50/18639	0.18	0.734944140197152	0.894745024722039	1
GO:0031406	carboxylic acid binding	39/4565	187/18639	0.20855614973262	0.851539556378162	0.89554123440695	1
GO:1901681	sulfur compound binding	59/4565	275/18639	0.214545454545455	0.875994025689535	0.895778476645754	1
GO:0022804	active transmembrane transporter activity	101/4565	457/18639	0.221006564551422	0.902374886456508	0.896910672260202	1
GO:0141003	histone H2AX kinase activity	77/4565	354/18639	0.217514124293785	0.888115172554625	0.899690628640067	1
GO:0042288	MHC class I protein binding	3/4565	20/18639	0.15	0.612453450164294	0.900385062480513	1
GO:0001530	lipopolysaccharide binding	7/4565	41/18639	0.170731707317073	0.697101487991879	0.905610589567835	1
GO:0015175	neutral L-amino acid transmembrane transporter activity	7/4565	41/18639	0.170731707317073	0.697101487991879	0.905610589567835	1
GO:0004033	aldo-keto reductase (NADPH) activity	6/4565	36/18639	0.166666666666667	0.680503833515882	0.905850147451116	1
GO:0016411	acylglycerol O-acyltransferase activity	5/4565	31/18639	0.161290322580645	0.658552096950853	0.907437295340943	1
GO:0047499	calcium-independent phospholipase A2 activity	5/4565	31/18639	0.161290322580645	0.658552096950853	0.907437295340943	1
GO:0043177	organic acid binding	39/4565	189/18639	0.206349206349206	0.842528555781568	0.909284296260007	1
GO:0005160	transforming growth factor beta receptor binding	4/4565	26/18639	0.153846153846154	0.628157384783891	0.911110818543597	1
GO:0008157	protein phosphatase 1 binding	4/4565	26/18639	0.153846153846154	0.628157384783891	0.911110818543597	1
GO:0004713	protein tyrosine kinase activity	28/4565	140/18639	0.2	0.816604600219058	0.912184776021844	1
GO:0004089	carbonate dehydratase activity	2/4565	15/18639	0.133333333333333	0.544403066812705	0.913347143888802	1
GO:0004559	alpha-mannosidase activity	2/4565	15/18639	0.133333333333333	0.544403066812705	0.913347143888802	1
GO:0034483	heparan sulfate sulfotransferase activity	2/4565	15/18639	0.133333333333333	0.544403066812705	0.913347143888802	1
GO:0140996	histone H3 kinase activity	77/4565	357/18639	0.215686274509804	0.880652019844082	0.914393408064621	1
GO:0005506	iron ion binding	31/4565	154/18639	0.201298701298701	0.821907227493208	0.915167609405264	1
GO:0008373	sialyltransferase activity	3/4565	21/18639	0.142857142857143	0.58328900015647	0.918151616131855	1
GO:0009975	cyclase activity	3/4565	21/18639	0.142857142857143	0.58328900015647	0.918151616131855	1
GO:0005504	fatty acid binding	8/4565	47/18639	0.170212765957447	0.694982638484305	0.918348431557364	1
GO:0019894	kinesin binding	7/4565	42/18639	0.166666666666667	0.680503833515882	0.918360760977337	1
GO:0042056	chemoattractant activity	7/4565	42/18639	0.166666666666667	0.680503833515882	0.918360760977337	1
GO:0022829	wide pore channel activity	6/4565	37/18639	0.162162162162162	0.662111838015453	0.919278585146068	1
GO:0042910	xenobiotic transmembrane transporter activity	5/4565	32/18639	0.15625	0.637972343921139	0.921515776444846	1
GO:0047498	calcium-dependent phospholipase A2 activity	5/4565	32/18639	0.15625	0.637972343921139	0.921515776444846	1
GO:0071813	lipoprotein particle binding	5/4565	32/18639	0.15625	0.637972343921139	0.921515776444846	1
GO:0071814	protein-lipid complex binding	5/4565	32/18639	0.15625	0.637972343921139	0.921515776444846	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	16/4565	86/18639	0.186046511627907	0.759632186250287	0.922568231971637	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	12/4565	67/18639	0.17910447761194	0.731287701688709	0.923011723381316	1
GO:0023026	MHC class II protein complex binding	4/4565	27/18639	0.148148148148148	0.604892296458561	0.925723493777104	1
GO:0035255	ionotropic glutamate receptor binding	4/4565	27/18639	0.148148148148148	0.604892296458561	0.925723493777104	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	4/4565	27/18639	0.148148148148148	0.604892296458561	0.925723493777104	1
GO:0005024	transforming growth factor beta receptor activity	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0005149	interleukin-1 receptor binding	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0015562	efflux transmembrane transporter activity	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0015923	mannosidase activity	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0022858	alanine transmembrane transporter activity	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0140327	flippase activity	2/4565	16/18639	0.125	0.510377875136911	0.930964853197709	1
GO:0032934	sterol binding	12/4565	68/18639	0.176470588235294	0.720533470781522	0.931804649586095	1
GO:0015377	chloride:monoatomic cation symporter activity	3/4565	22/18639	0.136363636363636	0.556775863785721	0.932976715330109	1
GO:0140767	enzyme-substrate adaptor activity	27/4565	139/18639	0.194244604316547	0.793105187263114	0.935384893728241	1
GO:0050698	proteoglycan sulfotransferase activity	4/4565	28/18639	0.142857142857143	0.58328900015647	0.938134198546567	1
GO:0051959	dynein light intermediate chain binding	4/4565	28/18639	0.142857142857143	0.58328900015647	0.938134198546567	1
GO:0015459	potassium channel regulator activity	10/4565	59/18639	0.169491525423729	0.692037796795812	0.938427776809722	1
GO:0005004	GPI-linked ephrin receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0005008	hepatocyte growth factor receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0005009	insulin receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0005011	macrophage colony-stimulating factor receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0005018	platelet-derived growth factor alpha-receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0005020	stem cell factor receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0008288	boss receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0036332	placental growth factor receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0038062	protein tyrosine kinase collagen receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0060175	brain-derived neurotrophic factor receptor activity	8/4565	49/18639	0.163265306122449	0.666616000178823	0.938537179124297	1
GO:0004382	GDP phosphatase activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0004935	adrenergic receptor activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0004955	prostaglandin receptor activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0005131	growth hormone receptor binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0008239	dipeptidyl-peptidase activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0015203	polyamine transmembrane transporter activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0015658	branched-chain amino acid transmembrane transporter activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0032052	bile acid binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0035256	G protein-coupled glutamate receptor binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0042166	acetylcholine binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0043208	glycosphingolipid binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0043422	protein kinase B binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0045322	unmethylated CpG binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0050308	sugar-phosphatase activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0070739	protein-glutamic acid ligase activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0070740	tubulin-glutamic acid ligase activity	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:1905394	retromer complex binding	1/4565	10/18639	0.1	0.408302300109529	0.939798244385932	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	5/4565	34/18639	0.147058823529412	0.600444558984601	0.944096857324782	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	5/4565	34/18639	0.147058823529412	0.600444558984601	0.944096857324782	1
GO:0051427	hormone receptor binding	5/4565	34/18639	0.147058823529412	0.600444558984601	0.944096857324782	1
GO:0019838	growth factor binding	26/4565	136/18639	0.191176470588235	0.780577926679982	0.944199450586137	1
GO:0008429	phosphatidylethanolamine binding	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0008484	sulfuric ester hydrolase activity	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0015278	intracellularly gated calcium channel activity	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0030169	low-density lipoprotein particle binding	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0030548	acetylcholine receptor regulator activity	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0036041	long-chain fatty acid binding	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0038191	neuropilin binding	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0051787	misfolded protein binding	2/4565	17/18639	0.117647058823529	0.480355647187681	0.945152613444472	1
GO:0005212	structural constituent of eye lens	3/4565	23/18639	0.130434782608696	0.532568217534168	0.945288228793857	1
GO:0005283	amino acid:sodium symporter activity	3/4565	23/18639	0.130434782608696	0.532568217534168	0.945288228793857	1
GO:0016849	phosphorus-oxygen lyase activity	3/4565	23/18639	0.130434782608696	0.532568217534168	0.945288228793857	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	7/4565	45/18639	0.155555555555556	0.63513691128149	0.948052831411045	1
GO:0140303	intramembrane lipid transporter activity	7/4565	45/18639	0.155555555555556	0.63513691128149	0.948052831411045	1
GO:0005416	amino acid:monoatomic cation symporter activity	4/4565	29/18639	0.137931034482759	0.563175586357971	0.948627715834852	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	6/4565	40/18639	0.15	0.612453450164294	0.950012009838577	1
GO:0004623	phospholipase A2 activity	5/4565	35/18639	0.142857142857143	0.58328900015647	0.953024160728497	1
GO:0015101	organic cation transmembrane transporter activity	14/4565	81/18639	0.172839506172839	0.705707679201655	0.954194969801659	1
GO:0005010	insulin-like growth factor receptor activity	8/4565	51/18639	0.156862745098039	0.640474196250242	0.954200076234233	1
GO:0005021	vascular endothelial growth factor receptor activity	8/4565	51/18639	0.156862745098039	0.640474196250242	0.954200076234233	1
GO:0005030	neurotrophin receptor activity	8/4565	51/18639	0.156862745098039	0.640474196250242	0.954200076234233	1
GO:0000099	sulfur amino acid transmembrane transporter activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0004143	ATP-dependent diacylglycerol kinase activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0004954	prostanoid receptor activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0008172	S-methyltransferase activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0008503	benzodiazepine receptor activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0016594	glycine binding	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0019203	carbohydrate phosphatase activity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0031731	CCR6 chemokine receptor binding	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0042608	T cell receptor binding	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0048407	platelet-derived growth factor binding	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0070697	activin receptor binding	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0097493	structural molecule activity conferring elasticity	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0098973	structural constituent of postsynaptic actin cytoskeleton	1/4565	11/18639	0.0909090909090909	0.371183909190481	0.954550566806793	1
GO:0004806	triacylglycerol lipase activity	3/4565	24/18639	0.125	0.510377875136911	0.955467895632033	1
GO:0015295	solute:proton symporter activity	3/4565	24/18639	0.125	0.510377875136911	0.955467895632033	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3/4565	24/18639	0.125	0.510377875136911	0.955467895632033	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	3/4565	24/18639	0.125	0.510377875136911	0.955467895632033	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	3/4565	24/18639	0.125	0.510377875136911	0.955467895632033	1
GO:0050431	transforming growth factor beta binding	3/4565	24/18639	0.125	0.510377875136911	0.955467895632033	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/4565	18/18639	0.111111111111111	0.453669222343921	0.956533363572871	1
GO:0099602	neurotransmitter receptor regulator activity	2/4565	18/18639	0.111111111111111	0.453669222343921	0.956533363572871	1
GO:0070566	adenylyltransferase activity	4/4565	30/18639	0.133333333333333	0.544403066812705	0.957463493347171	1
GO:0001727	lipid kinase activity	6/4565	41/18639	0.146341463414634	0.597515561135896	0.95762368188499	1
GO:0015179	L-amino acid transmembrane transporter activity	10/4565	62/18639	0.161290322580645	0.658552096950853	0.959104875150054	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	8/4565	52/18639	0.153846153846154	0.628157384783891	0.960605908544938	1
GO:0045505	dynein intermediate chain binding	5/4565	36/18639	0.138888888888889	0.567086527929901	0.960632872547429	1
GO:0016247	channel regulator activity	32/4565	168/18639	0.19047619047619	0.777718666875293	0.961948259080731	1
GO:0015171	amino acid transmembrane transporter activity	18/4565	102/18639	0.176470588235294	0.720533470781522	0.961980423014664	1
GO:0005537	D-mannose binding	3/4565	25/18639	0.12	0.489962760131435	0.963851448958639	1
GO:0030165	PDZ domain binding	14/4565	83/18639	0.168674698795181	0.688702674883543	0.964214848398034	1
GO:0005452	solute:inorganic anion antiporter activity	4/4565	31/18639	0.129032258064516	0.526841677560683	0.964874781940686	1
GO:0022840	leak channel activity	2/4565	19/18639	0.105263157894737	0.429791894852136	0.965630715820621	1
GO:0022842	narrow pore channel activity	2/4565	19/18639	0.105263157894737	0.429791894852136	0.965630715820621	1
GO:0004000	adenosine deaminase activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0004875	complement receptor activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0005165	neurotrophin receptor binding	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0005436	sodium:phosphate symporter activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0008499	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0015166	polyol transmembrane transporter activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0015368	calcium:monoatomic cation antiporter activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0035259	nuclear glucocorticoid receptor binding	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0070008	serine-type exopeptidase activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0140829	bicarbonate:monoatomic anion antiporter activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0140900	chloride:bicarbonate antiporter activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:1990817	poly(A) RNA polymerase activity	1/4565	12/18639	0.0833333333333333	0.340251916757941	0.965688459362462	1
GO:0038064	collagen receptor activity	8/4565	53/18639	0.150943396226415	0.616305358655893	0.966193372926373	1
GO:0099106	ion channel regulator activity	30/4565	160/18639	0.1875	0.765566812705367	0.96623703014584	1
GO:0005516	calmodulin binding	40/4565	207/18639	0.193236714975845	0.788989951902472	0.968263283418679	1
GO:0141108	transporter regulator activity	32/4565	170/18639	0.188235294117647	0.76856903550029	0.968279923313299	1
GO:0033293	monocarboxylic acid binding	13/4565	79/18639	0.164556962025316	0.671889860939731	0.968380857715201	1
GO:0008237	metallopeptidase activity	35/4565	184/18639	0.190217391304348	0.776661983903996	0.968457597688716	1
GO:0005096	GTPase activator activity	54/4565	271/18639	0.199261992619926	0.813591299111239	0.96876103477196	1
GO:0001786	phosphatidylserine binding	9/4565	59/18639	0.152542372881356	0.622834017116231	0.969958389375077	1
GO:0004435	phosphatidylinositol phospholipase C activity	3/4565	26/18639	0.115384615384615	0.471118038587918	0.970730661621471	1
GO:0043548	phosphatidylinositol 3-kinase binding	3/4565	26/18639	0.115384615384615	0.471118038587918	0.970730661621471	1
GO:0051139	metal cation:proton antiporter activity	3/4565	26/18639	0.115384615384615	0.471118038587918	0.970730661621471	1
GO:0015106	bicarbonate transmembrane transporter activity	4/4565	32/18639	0.125	0.510377875136911	0.971068925582949	1
GO:0035254	glutamate receptor binding	7/4565	49/18639	0.142857142857143	0.58328900015647	0.972557787592421	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	11/4565	70/18639	0.157142857142857	0.641617900172117	0.972796194353725	1
GO:0005326	neurotransmitter transmembrane transporter activity	2/4565	20/18639	0.1	0.408302300109529	0.97288023285841	1
GO:0016505	peptidase activator activity involved in apoptotic process	2/4565	20/18639	0.1	0.408302300109529	0.97288023285841	1
GO:0030627	pre-mRNA 5'-splice site binding	2/4565	20/18639	0.1	0.408302300109529	0.97288023285841	1
GO:0038024	cargo receptor activity	10/4565	65/18639	0.153846153846154	0.628157384783891	0.973351784619266	1
GO:0004222	metalloendopeptidase activity	19/4565	110/18639	0.172727272727273	0.705249427461914	0.973481501148468	1
GO:0035401	histone H3Y41 kinase activity	20/4565	115/18639	0.173913043478261	0.710090956712224	0.9739067473179	1
GO:0140801	histone H2AXY142 kinase activity	20/4565	115/18639	0.173913043478261	0.710090956712224	0.9739067473179	1
GO:0004465	lipoprotein lipase activity	1/4565	13/18639	0.0769230769230769	0.314078692391945	0.974097338033765	1
GO:0008035	high-density lipoprotein particle binding	1/4565	13/18639	0.0769230769230769	0.314078692391945	0.974097338033765	1
GO:0140333	glycerophospholipid flippase activity	1/4565	13/18639	0.0769230769230769	0.314078692391945	0.974097338033765	1
GO:1901338	catecholamine binding	1/4565	13/18639	0.0769230769230769	0.314078692391945	0.974097338033765	1
GO:0005543	phospholipid binding	104/4565	497/18639	0.209255533199195	0.854395155158773	0.974530126751716	1
GO:0032813	tumor necrosis factor receptor superfamily binding	7/4565	50/18639	0.14	0.571623220153341	0.97673812991972	1
GO:0019905	syntaxin binding	9/4565	61/18639	0.147540983606557	0.602413229669797	0.977815822243566	1
GO:0002020	protease binding	24/4565	136/18639	0.176470588235294	0.720533470781522	0.978339598210487	1
GO:0005123	death receptor binding	2/4565	21/18639	0.0952380952380952	0.388859333437647	0.978641139882258	1
GO:0042277	peptide binding	48/4565	249/18639	0.192771084337349	0.787088771295478	0.979459677396636	1
GO:0005161	platelet-derived growth factor receptor binding	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0005545	1-phosphatidylinositol binding	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0008331	high voltage-gated calcium channel activity	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0008392	arachidonate epoxygenase activity	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0015386	potassium:proton antiporter activity	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0019992	diacylglycerol binding	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0032454	histone H3K9 demethylase activity	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0043176	amine binding	1/4565	14/18639	0.0714285714285714	0.291644500078235	0.980445757011316	1
GO:0045499	chemorepellent activity	3/4565	28/18639	0.107142857142857	0.437466750117353	0.980943240688671	1
GO:0051019	mitogen-activated protein kinase binding	3/4565	28/18639	0.107142857142857	0.437466750117353	0.980943240688671	1
GO:0001540	amyloid-beta binding	13/4565	83/18639	0.156626506024096	0.639509626677576	0.981498569158166	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	2/4565	22/18639	0.0909090909090909	0.371183909190481	0.983207582337473	1
GO:0050321	tau-protein kinase activity	2/4565	22/18639	0.0909090909090909	0.371183909190481	0.983207582337473	1
GO:0140828	metal cation:monoatomic cation antiporter activity	5/4565	41/18639	0.121951219512195	0.497929634279913	0.984312709773898	1
GO:0004629	phospholipase C activity	3/4565	29/18639	0.103448275862069	0.422381689768478	0.98467195509488	1
GO:0099604	ligand-gated calcium channel activity	3/4565	29/18639	0.103448275862069	0.422381689768478	0.98467195509488	1
GO:0004953	icosanoid receptor activity	1/4565	15/18639	0.0666666666666667	0.272201533406353	0.985238515091495	1
GO:0015116	sulfate transmembrane transporter activity	1/4565	15/18639	0.0666666666666667	0.272201533406353	0.985238515091495	1
GO:0015250	water channel activity	1/4565	15/18639	0.0666666666666667	0.272201533406353	0.985238515091495	1
GO:0017081	chloride channel regulator activity	1/4565	15/18639	0.0666666666666667	0.272201533406353	0.985238515091495	1
GO:0050700	CARD domain binding	1/4565	15/18639	0.0666666666666667	0.272201533406353	0.985238515091495	1
GO:0016757	glycosyltransferase activity	51/4565	267/18639	0.191011235955056	0.779903269872134	0.985485232501424	1
GO:0005544	calcium-dependent phospholipid binding	7/4565	53/18639	0.132075471698113	0.539267188823906	0.986007967923126	1
GO:0004022	alcohol dehydrogenase (NAD+) activity	2/4565	23/18639	0.0869565217391304	0.355045478356112	0.986818949341627	1
GO:0016493	C-C chemokine receptor activity	2/4565	23/18639	0.0869565217391304	0.355045478356112	0.986818949341627	1
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	2/4565	23/18639	0.0869565217391304	0.355045478356112	0.986818949341627	1
GO:0099186	structural constituent of postsynapse	2/4565	23/18639	0.0869565217391304	0.355045478356112	0.986818949341627	1
GO:0098918	structural constituent of synapse	3/4565	30/18639	0.1	0.408302300109529	0.987695117511293	1
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	7/4565	54/18639	0.12962962962963	0.529280759401241	0.988235352491127	1
GO:0008391	arachidonate monooxygenase activity	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0015385	sodium:proton antiporter activity	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0019841	retinol binding	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0022841	potassium ion leak channel activity	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	1/4565	16/18639	0.0625	0.255188937568456	0.988856759217748	1
GO:0023023	MHC protein complex binding	4/4565	37/18639	0.108108108108108	0.441407892010302	0.989399224224867	1
GO:0030280	structural constituent of skin epidermis	4/4565	37/18639	0.108108108108108	0.441407892010302	0.989399224224867	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	2/4565	24/18639	0.0833333333333333	0.340251916757941	0.989669045133408	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	2/4565	24/18639	0.0833333333333333	0.340251916757941	0.989669045133408	1
GO:0004622	lysophospholipase activity	2/4565	24/18639	0.0833333333333333	0.340251916757941	0.989669045133408	1
GO:0019957	C-C chemokine binding	2/4565	24/18639	0.0833333333333333	0.340251916757941	0.989669045133408	1
GO:0008235	metalloexopeptidase activity	9/4565	66/18639	0.136363636363636	0.556775863785721	0.989946984943316	1
GO:0140457	protein demethylase activity	3/4565	31/18639	0.0967741935483871	0.395131258170512	0.990140153465286	1
GO:0005518	collagen binding	10/4565	72/18639	0.138888888888889	0.567086527929901	0.990819676301195	1
GO:0030020	extracellular matrix structural constituent conferring tensile strength	5/4565	44/18639	0.113636363636364	0.463979886488101	0.991196152777283	1
GO:0016500	protein-hormone receptor activity	9/4565	67/18639	0.134328358208955	0.548465776266531	0.991464474293916	1
GO:0050840	extracellular matrix binding	9/4565	67/18639	0.134328358208955	0.548465776266531	0.991464474293916	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/4565	17/18639	0.0588235294117647	0.240177823593841	0.991588268328577	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/4565	17/18639	0.0588235294117647	0.240177823593841	0.991588268328577	1
GO:0008569	minus-end-directed microtubule motor activity	1/4565	17/18639	0.0588235294117647	0.240177823593841	0.991588268328577	1
GO:0009881	photoreceptor activity	1/4565	17/18639	0.0588235294117647	0.240177823593841	0.991588268328577	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/4565	17/18639	0.0588235294117647	0.240177823593841	0.991588268328577	1
GO:0045236	CXCR chemokine receptor binding	1/4565	17/18639	0.0588235294117647	0.240177823593841	0.991588268328577	1
GO:0170055	lipid transmembrane transporter activity	7/4565	56/18639	0.125	0.510377875136911	0.991728786566978	1
GO:0004709	MAP kinase kinase kinase activity	2/4565	25/18639	0.08	0.326641840087623	0.991914053496432	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	21/4565	130/18639	0.161538461538462	0.659565254023085	0.992125744334968	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	31/4565	181/18639	0.171270718232044	0.699302281955547	0.99353512881932	1
GO:0004706	JUN kinase kinase kinase activity	1/4565	18/18639	0.0555555555555556	0.226834611171961	0.993650321549501	1
GO:0004970	glutamate-gated receptor activity	1/4565	18/18639	0.0555555555555556	0.226834611171961	0.993650321549501	1
GO:0005372	water transmembrane transporter activity	1/4565	18/18639	0.0555555555555556	0.226834611171961	0.993650321549501	1
GO:0015280	ligand-gated sodium channel activity	1/4565	18/18639	0.0555555555555556	0.226834611171961	0.993650321549501	1
GO:0022851	GABA-gated chloride ion channel activity	1/4565	18/18639	0.0555555555555556	0.226834611171961	0.993650321549501	1
GO:0050811	GABA receptor binding	1/4565	18/18639	0.0555555555555556	0.226834611171961	0.993650321549501	1
GO:0001637	G protein-coupled chemoattractant receptor activity	2/4565	26/18639	0.0769230769230769	0.314078692391945	0.993679336152678	1
GO:0004112	cyclic-nucleotide phosphodiesterase activity	2/4565	26/18639	0.0769230769230769	0.314078692391945	0.993679336152678	1
GO:0004950	chemokine receptor activity	2/4565	26/18639	0.0769230769230769	0.314078692391945	0.993679336152678	1
GO:0005112	Notch binding	2/4565	26/18639	0.0769230769230769	0.314078692391945	0.993679336152678	1
GO:0030247	polysaccharide binding	2/4565	26/18639	0.0769230769230769	0.314078692391945	0.993679336152678	1
GO:0019239	deaminase activity	3/4565	33/18639	0.0909090909090909	0.371183909190481	0.993701498153073	1
GO:0019956	chemokine binding	3/4565	33/18639	0.0909090909090909	0.371183909190481	0.993701498153073	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	49/4565	268/18639	0.182835820895522	0.746522862140557	0.99415335052282	1
GO:0016758	hexosyltransferase activity	34/4565	197/18639	0.17258883248731	0.704684172777867	0.994466159150683	1
GO:0008238	exopeptidase activity	15/4565	102/18639	0.147058823529412	0.600444558984601	0.994505466412179	1
GO:0043178	alcohol binding	13/4565	92/18639	0.141304347826087	0.576948902328682	0.994956673713403	1
GO:0005044	scavenger receptor activity	2/4565	27/18639	0.0740740740740741	0.302446148229281	0.995065158436731	1
GO:0005496	steroid binding	16/4565	108/18639	0.148148148148148	0.604892296458561	0.995074602512281	1
GO:0008146	sulfotransferase activity	6/4565	53/18639	0.113207547169811	0.46222901899192	0.995088505229744	1
GO:0140359	ABC-type transporter activity	5/4565	47/18639	0.106382978723404	0.43436414905269	0.995139774621403	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0004890	GABA-A receptor activity	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0005229	intracellularly calcium-gated chloride channel activity	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0008381	mechanosensitive monoatomic ion channel activity	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0016918	retinal binding	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0022821	solute:potassium antiporter activity	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0042834	peptidoglycan binding	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0043395	heparan sulfate proteoglycan binding	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0141147	intracellularly calcium-gated channel activity	1/4565	19/18639	0.0526315789473684	0.214895947426068	0.995206966312217	1
GO:0008081	phosphoric diester hydrolase activity	12/4565	87/18639	0.137931034482759	0.563175586357971	0.995238195124943	1
GO:0120013	lipid transfer activity	8/4565	65/18639	0.123076923076923	0.502525907827113	0.995382150034331	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	20/4565	130/18639	0.153846153846154	0.628157384783891	0.995890252434782	1
GO:0141052	histone H3 demethylase activity	2/4565	28/18639	0.0714285714285714	0.291644500078235	0.996151459801967	1
GO:0001972	retinoic acid binding	1/4565	20/18639	0.05	0.204151150054765	0.996382057546628	1
GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	1/4565	20/18639	0.05	0.204151150054765	0.996382057546628	1
GO:0015464	acetylcholine receptor activity	1/4565	20/18639	0.05	0.204151150054765	0.996382057546628	1
GO:0001216	DNA-binding transcription activator activity	96/4565	491/18639	0.195519348268839	0.798309996140831	0.996427071637782	1
GO:0001217	DNA-binding transcription repressor activity	50/4565	278/18639	0.179856115107914	0.734356654873254	0.99644050278917	1
GO:0004190	aspartic-type endopeptidase activity	3/4565	36/18639	0.0833333333333333	0.340251916757941	0.996820836706562	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/4565	36/18639	0.0833333333333333	0.340251916757941	0.996820836706562	1
GO:0004181	metallocarboxypeptidase activity	2/4565	29/18639	0.0689655172413793	0.281587793178986	0.997001793483973	1
GO:0015370	solute:sodium symporter activity	10/4565	79/18639	0.126582278481013	0.516838354569024	0.997082290228219	1
GO:0001846	opsonin binding	1/4565	21/18639	0.0476190476190476	0.194429666718823	0.997269103429846	1
GO:0015125	bile acid transmembrane transporter activity	1/4565	21/18639	0.0476190476190476	0.194429666718823	0.997269103429846	1
GO:0036122	BMP binding	1/4565	21/18639	0.0476190476190476	0.194429666718823	0.997269103429846	1
GO:0030551	cyclic nucleotide binding	3/4565	37/18639	0.0810810810810811	0.331055919007726	0.997475684866711	1
GO:0070001	aspartic-type peptidase activity	3/4565	37/18639	0.0810810810810811	0.331055919007726	0.997475684866711	1
GO:0030547	signaling receptor inhibitor activity	4/4565	44/18639	0.0909090909090909	0.371183909190481	0.997593645986427	1
GO:0005217	intracellularly ligand-gated monoatomic ion channel activity	2/4565	30/18639	0.0666666666666667	0.272201533406353	0.99766655605345	1
GO:0032452	histone demethylase activity	2/4565	30/18639	0.0666666666666667	0.272201533406353	0.99766655605345	1
GO:0048019	receptor antagonist activity	2/4565	30/18639	0.0666666666666667	0.272201533406353	0.99766655605345	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	93/4565	484/18639	0.192148760330579	0.784547808061698	0.997850356482997	1
GO:0008514	organic anion transmembrane transporter activity	47/4565	269/18639	0.174721189591078	0.713390635879103	0.997893826017737	1
GO:0005243	gap junction channel activity	1/4565	22/18639	0.0454545454545455	0.18559195459524	0.99793869967234	1
GO:0008970	phospholipase A1 activity	1/4565	22/18639	0.0454545454545455	0.18559195459524	0.99793869967234	1
GO:0033691	sialic acid binding	1/4565	22/18639	0.0454545454545455	0.18559195459524	0.99793869967234	1
GO:0005501	retinoid binding	3/4565	38/18639	0.0789473684210526	0.322343921139102	0.997998179409901	1
GO:0019840	isoprenoid binding	3/4565	38/18639	0.0789473684210526	0.322343921139102	0.997998179409901	1
GO:0042626	ATPase-coupled transmembrane transporter activity	13/4565	98/18639	0.13265306122449	0.541625500145294	0.998010623779189	1
GO:0005184	neuropeptide hormone activity	2/4565	31/18639	0.0645161290322581	0.263420838780341	0.99818561830091	1
GO:0046943	carboxylic acid transmembrane transporter activity	30/4565	188/18639	0.159574468085106	0.651546223579036	0.998375204546078	1
GO:0016917	GABA receptor activity	1/4565	23/18639	0.0434782608695652	0.177522739178056	0.998444142869191	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	4/4565	46/18639	0.0869565217391304	0.355045478356112	0.998445601654218	1
GO:0015294	solute:monoatomic cation symporter activity	16/4565	116/18639	0.137931034482759	0.563175586357971	0.998469773830984	1
GO:0005342	organic acid transmembrane transporter activity	30/4565	189/18639	0.158730158730159	0.648098889062744	0.99856199402892	1
GO:0160041	neuropeptide activity	2/4565	32/18639	0.0625	0.255188937568456	0.998590456913752	1
GO:0000149	SNARE binding	14/4565	106/18639	0.132075471698113	0.539267188823906	0.998663289290733	1
GO:0015149	hexose transmembrane transporter activity	1/4565	24/18639	0.0416666666666667	0.17012595837897	0.998825668857703	1
GO:0030552	cAMP binding	1/4565	24/18639	0.0416666666666667	0.17012595837897	0.998825668857703	1
GO:0055056	D-glucose transmembrane transporter activity	1/4565	24/18639	0.0416666666666667	0.17012595837897	0.998825668857703	1
GO:0042923	neuropeptide binding	2/4565	33/18639	0.0606060606060606	0.247455939460321	0.998905873607989	1
GO:0042287	MHC protein binding	3/4565	41/18639	0.0731707317073171	0.298757780567948	0.999008656983998	1
GO:0001848	complement binding	1/4565	25/18639	0.04	0.163320920043812	0.999113652831089	1
GO:0015271	outward rectifier potassium channel activity	1/4565	25/18639	0.04	0.163320920043812	0.999113652831089	1
GO:0015020	glucuronosyltransferase activity	2/4565	34/18639	0.0588235294117647	0.240177823593841	0.999151375880486	1
GO:0005319	lipid transporter activity	27/4565	178/18639	0.151685393258427	0.619334949604342	0.999161024808634	1
GO:0004620	phospholipase activity	14/4565	109/18639	0.128440366972477	0.524424972617744	0.999172797949865	1
GO:0005227	calcium-activated cation channel activity	1/4565	26/18639	0.0384615384615385	0.157039346195973	0.999331025498226	1
GO:0008066	glutamate receptor activity	1/4565	26/18639	0.0384615384615385	0.157039346195973	0.999331025498226	1
GO:0015145	monosaccharide transmembrane transporter activity	1/4565	26/18639	0.0384615384615385	0.157039346195973	0.999331025498226	1
GO:0008375	acetylglucosaminyltransferase activity	3/4565	43/18639	0.0697674418604651	0.284862069843857	0.999382781925551	1
GO:0070851	growth factor receptor binding	19/4565	139/18639	0.136690647482014	0.558111057703673	0.999451767318111	1
GO:0015291	secondary active transmembrane transporter activity	48/4565	287/18639	0.167247386759582	0.682874927012453	0.999474394966732	1
GO:0008395	steroid hydroxylase activity	1/4565	27/18639	0.037037037037037	0.15122307411464	0.999495097308283	1
GO:0004867	serine-type endopeptidase inhibitor activity	11/4565	95/18639	0.115789473684211	0.472771084337349	0.999506549571584	1
GO:0008201	heparin binding	25/4565	172/18639	0.145348837209302	0.593462645508036	0.999534157638789	1
GO:0043394	proteoglycan binding	2/4565	37/18639	0.0540540540540541	0.220703946005151	0.999605740420604	1
GO:0051119	sugar transmembrane transporter activity	1/4565	28/18639	0.0357142857142857	0.145822250039118	0.999618935734443	1
GO:0017046	peptide hormone binding	4/4565	53/18639	0.0754716981132075	0.308152679327946	0.999675724682666	1
GO:0004180	carboxypeptidase activity	3/4565	46/18639	0.0652173913043478	0.266284108767084	0.999698932853735	1
GO:0015026	coreceptor activity	5/4565	61/18639	0.0819672131147541	0.33467401648322	0.999743822454679	1
GO:0022839	monoatomic ion-gated channel activity	1/4565	30/18639	0.0333333333333333	0.136100766703176	0.999782951619396	1
GO:0004497	monooxygenase activity	12/4565	106/18639	0.113207547169811	0.46222901899192	0.999802037265642	1
GO:0008188	neuropeptide receptor activity	3/4565	48/18639	0.0625	0.255188937568456	0.999814246596502	1
GO:0015144	carbohydrate transmembrane transporter activity	2/4565	40/18639	0.05	0.204151150054765	0.999817886852394	1
GO:0071855	neuropeptide receptor binding	2/4565	40/18639	0.05	0.204151150054765	0.999817886852394	1
GO:0120015	sterol transfer activity	1/4565	32/18639	0.03125	0.127594468784228	0.999876381197204	1
GO:0048020	CCR chemokine receptor binding	3/4565	50/18639	0.06	0.244981380065717	0.999885754145329	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	9/4565	91/18639	0.0989010989010989	0.403815461646787	0.99988926291809	1
GO:0030296	protein tyrosine kinase activator activity	1/4565	33/18639	0.0303030303030303	0.12372796973016	0.999906709559366	1
GO:0061134	peptidase regulator activity	33/4565	226/18639	0.146017699115044	0.596193624053737	0.99991160564501	1
GO:0008083	growth factor activity	21/4565	162/18639	0.12962962962963	0.529280759401241	0.999913611353086	1
GO:0005201	extracellular matrix structural constituent	22/4565	168/18639	0.130952380952381	0.534681583476764	0.999920079783566	1
GO:0015293	symporter activity	18/4565	146/18639	0.123287671232877	0.50338639739531	0.9999229113282	1
GO:0016298	lipase activity	15/4565	130/18639	0.115384615384615	0.471118038587918	0.999936526204241	1
GO:0008009	chemokine activity	2/4565	45/18639	0.0444444444444444	0.181467688937568	0.999950276221377	1
GO:0042605	peptide antigen binding	2/4565	45/18639	0.0444444444444444	0.181467688937568	0.999950276221377	1
GO:0005178	integrin binding	20/4565	161/18639	0.124223602484472	0.507207826223017	0.999958090154077	1
GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	1/4565	36/18639	0.0277777777777778	0.11341730558598	0.999959908764175	1
GO:0005253	monoatomic anion channel activity	10/4565	103/18639	0.0970873786407767	0.396410000106339	0.999963878325328	1
GO:0008194	UDP-glycosyltransferase activity	17/4565	145/18639	0.117241379310345	0.478699248404275	0.999964780404894	1
GO:0099095	ligand-gated monoatomic anion channel activity	2/4565	47/18639	0.0425531914893617	0.173745659621076	0.999970513402425	1
GO:0038187	pattern recognition receptor activity	2/4565	48/18639	0.0416666666666667	0.17012595837897	0.999977307611378	1
GO:0008509	monoatomic anion transmembrane transporter activity	17/4565	149/18639	0.114093959731544	0.465848261869933	0.999982267435424	1
GO:0061135	endopeptidase regulator activity	23/4565	184/18639	0.125	0.510377875136911	0.999984500001385	1
GO:0005272	sodium channel activity	2/4565	51/18639	0.0392156862745098	0.16011854906256	0.999989681240447	1
GO:0008227	G protein-coupled amine receptor activity	1/4565	41/18639	0.024390243902439	0.0995859268559827	0.999990191902534	1
GO:0005254	chloride channel activity	6/4565	83/18639	0.072289156626506	0.295158289235804	0.999990746539552	1
GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	2/4565	53/18639	0.0377358490566038	0.154076339663973	0.999993909280948	1
GO:0005245	voltage-gated calcium channel activity	1/4565	43/18639	0.0232558139534884	0.0949540232812858	0.999994415995756	1
GO:0019955	cytokine binding	15/4565	144/18639	0.104166666666667	0.425314895947426	0.999994798620472	1
GO:0022824	transmitter-gated monoatomic ion channel activity	3/4565	63/18639	0.0476190476190476	0.194429666718823	0.999995447422147	1
GO:0022835	transmitter-gated channel activity	3/4565	63/18639	0.0476190476190476	0.194429666718823	0.999995447422147	1
GO:0005539	glycosaminoglycan binding	32/4565	242/18639	0.132231404958678	0.539903867913427	0.999995766908759	1
GO:0042562	hormone binding	7/4565	94/18639	0.074468085106383	0.304054904336883	0.999996140110872	1
GO:0042379	chemokine receptor binding	4/4565	72/18639	0.0555555555555556	0.226834611171961	0.999996290849455	1
GO:0004175	endopeptidase activity	63/4565	405/18639	0.155555555555556	0.63513691128149	0.999996480614055	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/4565	56/18639	0.0357142857142857	0.145822250039118	0.999997244827601	1
GO:0005179	hormone activity	12/4565	132/18639	0.0909090909090909	0.371183909190481	0.999998545978246	1
GO:0015103	inorganic anion transmembrane transporter activity	17/4565	165/18639	0.103030303030303	0.420675097082545	0.999998983738489	1
GO:0015108	chloride transmembrane transporter activity	10/4565	121/18639	0.0826446280991736	0.337439917445892	0.999999045122086	1
GO:0004866	endopeptidase inhibitor activity	16/4565	161/18639	0.0993788819875776	0.405766260978414	0.999999314295683	1
GO:0017171	serine hydrolase activity	22/4565	198/18639	0.111111111111111	0.453669222343921	0.999999424925369	1
GO:0030414	peptidase inhibitor activity	17/4565	169/18639	0.100591715976331	0.410718290051006	0.999999515507124	1
GO:0008236	serine-type peptidase activity	21/4565	194/18639	0.108247422680412	0.441976716613408	0.99999958821946	1
GO:0004252	serine-type endopeptidase activity	18/4565	176/18639	0.102272727272727	0.417581897839291	0.999999589570696	1
GO:0005230	extracellular ligand-gated monoatomic ion channel activity	3/4565	73/18639	0.0410958904109589	0.167795465798437	0.999999639703047	1
GO:0001664	G protein-coupled receptor binding	38/4565	297/18639	0.127946127946128	0.522406983305121	0.999999852535921	1
GO:0015081	sodium ion transmembrane transporter activity	15/4565	164/18639	0.0914634146341463	0.373447225709935	0.999999884486424	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/4565	69/18639	0.0289855072463768	0.118348492785371	0.99999991395219	1
GO:0004896	cytokine receptor activity	5/4565	96/18639	0.0520833333333333	0.212657447973713	0.999999922655078	1
GO:0030246	carbohydrate binding	34/4565	280/18639	0.121428571428571	0.495795650133	0.999999935688335	1
GO:0008528	G protein-coupled peptide receptor activity	7/4565	122/18639	0.0573770491803279	0.234271811538254	0.999999993325788	1
GO:0005126	cytokine receptor binding	30/4565	275/18639	0.109090909090909	0.445420691028577	0.999999996884982	1
GO:0001653	peptide receptor activity	7/4565	128/18639	0.0546875	0.223290320372399	0.999999998371504	1
GO:0030594	neurotransmitter receptor activity	3/4565	97/18639	0.0309278350515464	0.126279061889545	0.999999999285927	1
GO:0099094	ligand-gated monoatomic cation channel activity	7/4565	136/18639	0.0514705882352941	0.210155595644611	0.999999999756835	1
GO:0005125	cytokine activity	21/4565	234/18639	0.0897435897435897	0.366425141123936	0.999999999770456	1
GO:0015085	calcium ion transmembrane transporter activity	8/4565	147/18639	0.054421768707483	0.222205333392941	0.999999999883801	1
GO:0005249	voltage-gated potassium channel activity	2/4565	98/18639	0.0204081632653061	0.0833270000223529	0.999999999966422	1
GO:0030527	structural constituent of chromatin	2/4565	98/18639	0.0204081632653061	0.0833270000223529	0.999999999966422	1
GO:0005262	calcium channel activity	5/4565	131/18639	0.0381679389312977	0.155840572560889	0.999999999986716	1
GO:0005267	potassium channel activity	3/4565	124/18639	0.0241935483870968	0.098782814542628	0.999999999999442	1
GO:0022834	ligand-gated channel activity	10/4565	188/18639	0.0531914893617021	0.217182074526345	0.999999999999705	1
GO:0005244	voltage-gated monoatomic ion channel activity	8/4565	173/18639	0.046242774566474	0.188810312189378	0.999999999999771	1
GO:0140375	immune receptor activity	6/4565	156/18639	0.0384615384615385	0.157039346195973	0.999999999999773	1
GO:0022832	voltage-gated channel activity	8/4565	175/18639	0.0457142857142857	0.18665248005007	0.999999999999859	1
GO:0015276	ligand-gated monoatomic ion channel activity	9/4565	186/18639	0.0483870967741935	0.197565629085256	0.999999999999929	1
GO:0022843	voltage-gated monoatomic cation channel activity	4/4565	143/18639	0.027972027972028	0.114210433597071	0.999999999999946	1
GO:0015079	potassium ion transmembrane transporter activity	5/4565	160/18639	0.03125	0.127594468784228	0.999999999999992	1
GO:0003823	antigen binding	4/4565	174/18639	0.0229885057471264	0.0938625977263285	1	1
GO:0005216	monoatomic ion channel activity	21/4565	448/18639	0.046875	0.191391703176342	1	1
GO:0005261	monoatomic cation channel activity	10/4565	341/18639	0.0293255131964809	0.119736744900155	1	1
GO:0022836	gated channel activity	18/4565	318/18639	0.0566037735849057	0.23111450949596	1	1
GO:0030371	translation repressor activity	11/4565	329/18639	0.033434650455927	0.136514446845131	1	1
GO:0045182	translation regulator activity	24/4565	356/18639	0.0674157303370786	0.27525997760193	1	1
GO:0046873	metal ion transmembrane transporter activity	39/4565	450/18639	0.0866666666666667	0.353861993428259	1	1