category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	83/1708	158/9376	2.88370438443068	CCNE1/CCNB1/PTTG1/CDC20/CCNB2/CDK1/CCNA2/AURKB/MAD2L1/YWHAB/YWHAQ/SMC1A/CDCA5/DBF4/TGFB1/ANAPC11/NDC80/FBXO5/PRKDC/SFN/PLK1/RAD21/ORC6/ESCO2/CDC6/PKMYT1/BUB3/TTK/TFDP1/CDC25A/PCNA/NIPBL/ANAPC5/BUB1/PDS5B/CDT1/YWHAH/CHEK1/CDC25C/E2F1/ATRX/TRIP13/PPP2R1A/HDAC1/CCNE2/YWHAE/CDC25B/ORC1/BUB1B/PPP2R5C/PPP2R1B/CDC26/ANAPC7/CDC45/PDS5A/HDAC2/STAG2/E2F3/GADD45A/MCM7/WEE1/ATM/CCND2/MAD2L2/CDC27/CDK4/CUL1/MYC/PPP2R5E/EP300/CCND3/ANAPC10/ANAPC1/ORC2/ABL1/CHEK2/CDC14B/E2F5/SMC3/CDKN2D/MAU2/RBL1/PPP2R5A	11.2696767551015
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	56/1708	108/9376	2.84638737097753	RAN/KPNA2/RBM8A/KPNB1/ALYREF/IPO5/PNN/CSE1L/XPO1/NUP37/SUMO2/IPO7/UPF3B/EIF4A3/MAGOHB/NDC1/NCBP2/THOC2/SEH1L/NUP88/NUP62/NUP50/KPNA4/NUP160/NUP155/NUP153/THOC1/NUP205/RAE1/ACIN1/SEC13/POM121C/AHCTF1/NUP210/NUP98/IPO9/TNPO1/NCBP1/CASC3/POM121/TNPO3/THOC3/NMD3/TMEM33/NUP107/RANBP2/DDX39B/PHAX/RANGAP1/TPR/THOC5/NUP43/TNPO2/NUP188/NUP54/XPO5	9.10815065298523
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	76/1708	174/9376	2.39769576570029	HSPA5/CALR/PDIA6/SSR4/HSP90B1/HSP90AB1/LMAN1/HSP90AA1/OSTC/MAN1A2/HSPA8/SSR3/CRYAB/PDIA4/CANX/RRBP1/STT3B/PDIA3/XBP1/UBXN4/DNAJB11/SAR1A/P4HB/RPN2/DNAJC3/LMAN2/GANAB/SSR1/DNAJC1/SEC61B/STT3A/SEC61A1/SSR2/SEC61G/CKAP4/KRTCAP2/EIF2S1/MAGT1/SAR1B/HSPH1/PRKCSH/UGGT1/DNAJC10/DNAJA1/SEC63/HSPBP1/DERL1/DERL2/BAK1/HYOU1/UBE2D2/RPN1/DAD1/UBE2D3/BCAP29/ERP29/WFS1/EDEM2/ATXN3/UBE2J2/EDEM1/TRAM1/SEC13/SEC23B/MOGS/UBXN1/OS9/SEC23A/UBE2G1/CUL1/ATF6/ERN1/PLAA/SEL1L/MAN1B1/MBTPS2	8.78283408062061
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	23/1708	36/9376	3.50715586781161	RNASEH2C/RNASEH2A/POLD2/SSBP1/RPA3/PCNA/PRIM1/RNASEH1/POLE4/RNASEH2B/FEN1/LIG1/POLD1/RFC4/POLA2/DNA2/RFC3/MCM7/RFC2/POLE/POLE2/RFC5/POLD3	7.11291577304478
Genetic Information Processing	Transcription	hsa03040	Spliceosome	79/1708	243/9376	1.78463970085099	SRSF3/HNRNPA1/HNRNPA3/SRSF7/RBM8A/LSM4/SRSF2/HSPA8/TXNL4A/HNRNPM/HNRNPU/RBMX/HNRNPC/FUS/SNRPA/SNRPD1/SRSF5/ALYREF/DDX5/RBM25/TRA2A/SRSF6/LSM5/SNRPE/SRSF9/LSM7/LSM2/SNRPF/SRSF1/TRA2B/PPIH/SNRNP70/SNRPD2/PRPF40A/EIF4A3/DDX46/HNRNPK/SNRPB/U2SURP/MAGOHB/U2AF1/PRPF38B/SF3B5/NCBP2/SF3B1/THOC2/SNRPG/TCERG1/LSM6/SRSF4/SRSF10/PRPF4/BCAS2/RBMX2/SNRNP40/LSM3/SF1/RBM17/THOC1/ACIN1/PUF60/HNRNPA1L2/U2AF2/DDX23/NCBP1/PRPF38A/CASC3/THOC3/SF3B3/PLRG1/PRPF8/DDX39B/PPIL1/DHX15/THOC5/PRPF31/CWC25/RBM22/PQBP1	5.84864425126355
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	28/1708	56/9376	2.74473067915691	OSTC/MAN1A2/STT3B/RPN2/MAN2A1/GANAB/DHRSX/B4GALT1/STT3A/KRTCAP2/MAGT1/SRD5A3/DPAGT1/RPN1/DAD1/ALG8/MGAT1/ALG9/MOGS/ALG2/MGAT3/ALG12/B4GALT2/DPM1/ALG3/DOLPP1/MAN1B1/B4GALT3	6.18020632719308
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	42/1708	103/9376	2.23842113639981	RBM8A/PPP1CC/FUS/PABPC4/PPP1CB/PPP1CA/ALYREF/PNN/DAZAP1/PAPOLA/PABPC1/UPF3B/EIF4A3/GSPT1/MAGOHB/NCBP2/CPSF6/PPP2R1A/FIP1L1/ETF1/TARDBP/PABPN1/PPP2R5C/PPP2R1B/WDR33/CPSF3/SMG7/NUDT21/ACIN1/SMG1/CPSF2/NCBP1/CASC3/SMG6/CPSF1/MSI2/PPP2R5E/DDX39B/CSTF2/PPP2R3A/PCF11/PPP2R5A	5.96438071536569
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	107/1708	368/9376	1.59612055798799	GPX3/TUBA1C/TUBA1B/TUBB/CHCHD10/HSPA5/NDUFA4/ACTG1/UQCRH/SRSF3/HNRNPA1/HNRNPA3/SRSF7/TUBB4B/NDUFV3/ACTB/TUBB6/COX5A/CYC1/CYCS/FUS/TOMM40/XBP1/ALYREF/HNRNPA2B1/NDUFC1/NDUFA6/PSMA7/COX8C/COX8A/NDUFB11/NUP37/VDAC1/PFN1/UQCRFS1/SIGMAR1/COX7B/NDUFV2/NDUFS6/NDUFS7/COX5B/NDUFA3/PSMA4/EIF2S1/MAPK13/KIF5B/NDUFA12/PPP3CA/NDUFS2/NDC1/DERL1/SEH1L/PSMC5/NUP88/NUP62/PSMC4/SLC1A2/NDUFA9/NUP50/COX6A1/TARDBP/PSMB3/NUP160/NOS2/PSMD2/NUP155/NUP153/UQCRC1/NUP205/PSMB6/DNALI1/RAE1/COX7A2L/GPX7/DNAH14/PSMD14/SEC13/GPX8/BID/POM121C/PSMD11/NUP210/HNRNPA1L2/NUP98/RB1CC1/NCBP1/POM121/NDUFS3/CCS/PSMD12/MATR3/ATF6/TANK/ERN1/SDHA/NUP107/APAF1/RANBP2/DCTN2/TPR/VAPB/NUP43/SETX/ATG2A/NUP188/NUP54/TNFRSF1A	5.5059509627699
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	23/1708	44/9376	2.86949116457313	HMGB1/POLD2/APEX1/NTHL1/SMUG1/PCNA/POLE4/FEN1/LIG1/POLD1/RFC4/RFC3/MBD4/OGG1/RFC2/LIG3/PNKP/POLE/POLE2/RFC5/POLG2/TDP1/POLD3	5.8661195484035
Genetic Information Processing	Translation	hsa03010	Ribosome	71/1708	222/9376	1.75563854252379	RPS9/RPL29/RPL28/RPL7A/RPL18A/RPS3A/RPL36/RPSA/RPS15/RPL19/RPL15/RPLP0/MRPL23/RPS5/RPS6/RPL8/RPL5/MRPL41/MRPL11/MRPS15/RPL22L1/RPS18/RPL13A/RPL14/RPL6/RPS19/MRPS9/RPL4/MRPS16/RPL3/MRPL51/MRPL3/MRPL47/MRPL37/MRPS5/MRPS14/MRPL32/MRPL4/MRPL14/MRPL52/MRPS12/MRPS35/MRPS27/MRPL12/MRPS31/MRPS22/MRPL40/MRPS2/MRPL35/RPL26L1/RSL24D1/MRPL20/MRPL22/MRPS7/MRPL50/MRPL42/MRPL21/MRPL19/MRPL18/DAP3/MRPL15/MRPL9/MRPS30/MRPL2/MRPL28/MRPS25/MRPL45/MRPL24/MRPS18A/MRPS23/MRPL39	5.37741623634579
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	18/1708	31/9376	3.18742917579512	HSPA5/SEC11A/SPCS3/SRP9/SRP72/SEC11C/SRPRB/SEC61B/SEC61A1/SEC61G/OXA1L/SEC63/SPCS2/SRP19/UBL4A/IMMP1L/SRP68/SGTA	5.7572317760796
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	41/1708	116/9376	1.94024065250747	PKM/ENO1/GAPDH/PHGDH/ACAT2/TPI1/PFKP/PCCA/ACAT1/PGLS/PRPS2/GPI/SHMT1/PGAM1/PGK1/IDH3G/MDH2/CS/MDH1/FH/GLDC/RPIA/ESD/SUCLG2/GPT2/PCCB/HK1/IDH3A/HK2/SHMT2/ADH5/ACSS2/G6PD/PGP/DLAT/PC/PFKL/SDHA/PDHB/PRPS1/GOT1	4.80895867533573
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	30/1708	78/9376	2.11133129165916	ENO1/LSM4/EXOSC8/PABPC4/PFKP/LSM5/LSM7/DCPS/LSM2/EXOSC5/PABPC1/EXOSC3/EXOSC9/PNPT1/TOB2/HSPD1/LSM6/HSPA9/EXOSC2/LSM3/DCP1A/XRN2/CNOT3/EXOSC7/NUDT16/TOB1/PFKL/CNOT6/ZCCHC7/EXOSC10	4.65140968280986
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	60/1708	203/9376	1.6225008940829	CAV1/ACTG1/PGF/LAMA4/PPP1CC/ACTB/COL1A1/GRB2/CDC42/PPP1CB/PPP1CA/COL6A2/COL4A1/COL6A3/COL4A2/ITGA5/FLNB/RHOA/COL6A1/DIAPH1/IGF1/COL1A2/PPP1R12A/VCL/FLNA/PTEN/COL9A3/LAMB1/ACTN1/TLN1/ITGAV/LAMA1/RAC3/ERBB2/ITGB1/FLT4/FYN/PXN/PARVA/LAMC1/MYL5/ACTN4/PIK3CB/ROCK1/CRKL/AKT1/CCND2/LAMA5/BRAF/PIP5K1C/CCND3/CAV2/XIAP/CRK/VAV2/ITGB5/RAF1/VASP/ARHGAP5/MAPK1	4.2317579718765
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	31/1708	85/9376	2.00203884832622	TK1/RRM2/TYMS/DTYMK/DUT/NME1/IMPDH2/GMPS/NT5C/AK1/AK2/ADA/NT5C3B/HPRT1/HDDC2/NME2/ADK/AK5/CTPS1/RRM1/IMPDH1/ADSL/ITPA/NME1-NME2/UCK2/NUDT16/NT5M/UCK1/NME6/CANT1/DCTD	4.37977006804846
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	45/1708	142/9376	1.73961803608536	UBE2S/UBE2C/CDC20/SAE1/UBE2E3/CBLB/UBE2L3/ANAPC11/UBA1/UBE2F/ANAPC5/UBE2K/UBA2/FBXW7/HERC3/UBE2D2/UBE2D3/UBE2N/HERC4/BRCA1/HUWE1/UBE2M/UBE2J2/CUL4B/CDC26/ANAPC7/ITCH/UBR5/RCHY1/SOCS3/CDC27/UBE2G1/RHOBTB2/UBE4A/CUL1/CUL4A/ANAPC10/ANAPC1/XIAP/UBA6/TRIP12/PML/VHL/HERC2/CUL2	4.19126624315064
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	28/1708	75/9376	2.04939890710382	CCNE1/CCNB1/RRM2/CCNB2/CDK1/CYCS/SIVA1/GTSE1/SFN/IGF1/PTEN/CHEK1/EI24/CCNE2/IGFBP3/MDM4/TP53I3/GADD45A/BID/ATM/RCHY1/CCND2/CCNG2/CDK4/APAF1/CCND3/CHEK2/CCNG1	4.30620733474418
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	48/1708	157/9376	1.67830665731887	HLA-G/CCNE1/CALM3/CCNB1/HLA-C/CALM1/CCNB2/CDK1/CCNA2/EIF4EBP1/PPP1CC/PPP1CB/MYBL2/PPP1CA/TGFB1/MAP2K2/VDAC1/VDAC3/HLA-E/MAPK13/FOXM1/PTEN/PPP3CA/CDC25A/CHEK1/E2F1/FOXO1/CCNE2/IGFBP3/HUS1/VDAC2/PIK3CB/PPID/E2F3/GADD45A/ATM/AKT1/CCND2/CDK4/FOXO3/MYC/CCND3/TRPM7/CHEK2/E2F5/RBL1/RAF1/MAPK1	4.04503717739583
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	19/1708	44/9376	2.37044922290824	OSTC/MAN1A2/STT3B/RPN2/MAN2A1/B4GALT1/STT3A/KRTCAP2/MAGT1/RPN1/DAD1/MGAT1/ALG9/ALG2/ALG12/B4GALT2/ALG3/MAN1B1/B4GALT3	4.30021768967923
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	38/1708	117/9376	1.78290197962329	ACTG1/ACTB/RUVBL2/CDK2AP2/BPTF/SMARCC1/GATAD2A/MBD2/RUVBL1/CHD4/BAZ1B/HDAC1/SMARCA4/BAZ1A/BRD9/CHD3/ACTR6/SMARCB1/PBRM1/MRGBP/SMARCA5/ARID1A/EPC1/HDAC2/YY1/CHRAC1/CDK2AP1/MTA3/MTA1/ACTL6A/MCRS1/INO80/PHF6/EP400/UCHL5/SMARCD1/SS18/ARID2	4.02167340611197
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	43/1708	138/9376	1.71048433628619	CCNE1/CALM3/CCNB1/PTTG1/CALM1/CDC20/CCNB2/CDK1/PPP1CC/MAD2L1/AURKA/PPP1CB/YWHAB/YWHAQ/PPP1CA/SMC1A/ANAPC11/FBXO5/IGF1/PLK1/MAPK13/PKMYT1/PPP3CA/ANAPC5/BUB1/YWHAH/CDC25C/PPP2R1A/CCNE2/YWHAE/PPP2R5C/PPP2R1B/CDC26/ANAPC7/MAD2L2/CDC27/CUL1/PPP2R5E/ANAPC10/ANAPC1/SMC3/PPP2R5A/MAPK1	3.96820035112431
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	26/1708	71/9376	2.01022528614309	LDHA/PKM/SLC16A3/SLC2A1/PFKP/MAP2K2/SLC1A5/PGAM1/FGFR1/PTEN/HIF1A/ERBB2/SLC7A5/FGFR3/HK1/HK2/PIK3CB/SCO2/AKT1/G6PD/MYC/PFKL/PDHB/PDK1/RAF1/MAPK1	4.0325312320078
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	27/1708	75/9376	1.97620608899297	PKM/ENO1/GAPDH/PHGDH/TPI1/PFKP/CBS/PRPS2/SHMT1/ASL/PGAM1/PGK1/IDH3G/MAT2A/CS/ASNS/RPIA/GPT2/PYCR1/IDH3A/SHMT2/PC/PFKL/ARG2/PRPS1/ALDH18A1/GOT1	4.00586068099228
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/1708	23/9376	2.86406679564199	POLD2/SSBP1/RPA3/PCNA/LIG1/POLD1/RFC4/RFC3/MSH2/RFC2/RFC5/POLD3	4.22414133338054
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	72/1708	268/9376	1.47478066342759	TUBA1C/TUBA1B/TUBB/CALM3/HSPA5/CALM1/NDUFA4/UQCRH/TUBB4B/NDUFV3/TUBB6/COX5A/PPIF/CYC1/CYCS/SLC39A4/XBP1/NDUFC1/NDUFA6/PSMA7/UBE2L3/COX8C/COX8A/NDUFB11/PARK7/VDAC1/SLC18A2/UQCRFS1/COX7B/NDUFV2/NDUFS6/UBA1/HTRA2/VDAC3/NDUFS7/TXN2/COX5B/NDUFA3/PSMA4/EIF2S1/KIF5B/NDUFA12/SLC39A10/NDUFS2/GNAI3/PSMC5/PSMC4/SLC39A6/NDUFA9/COX6A1/PSMB3/SLC39A1/SNCA/PSMD2/UQCRC1/UBE2J2/VDAC2/PSMB6/COX7A2L/PSMD14/PSMD11/NDUFS3/UBE2G1/PSMD12/ATF6/ERN1/SDHA/APAF1/SLC39A3/MFN1/MAOA/SLC39A8	3.72166628613854
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	62/1708	224/9376	1.51940448310472	HLA-G/CCNE1/PTTG1/HLA-C/RAN/CDC20/CALR/CCNB2/CCNA2/RANBP1/MAD2L1/CANX/SLC2A1/TGFB1/IL1R1/TSPO/MAP2K2/ANAPC11/XPO1/VDAC1/NFYB/JAK1/FDPS/VDAC3/HLA-E/BUB3/PTEN/PPP3CA/ANAPC5/TLN1/CRTC3/CHEK1/E2F1/EGR1/TBPL1/CCNE2/BUB1B/CREB1/CDC26/ANAPC7/VDAC2/CREB3L2/PIK3CB/IL2RB/E2F3/ATM/AKT1/CCND2/CDC27/TCF3/CDK4/FOS/MYC/EP300/CCND3/ANAPC10/ANAPC1/XIAP/CHEK2/SRF/TNFRSF1A/MAPK1	3.71330152996223
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	97/1708	388/9376	1.37236533957845	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	3.53542883322
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	23/1708	63/9376	2.00408906732092	ACAT2/EZH2/ACAT1/HYKK/AADAT/PLOD1/COLGALT1/HADH/GCDH/ALDH1B1/DHTKD1/KMT2C/ALDH3A2/SMYD3/ALDH2/ALDH9A1/SUV39H2/KMT2A/SETD2/ASH1L/KMT2B/PLOD3/KMT2E	3.77386387542693
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	19/1708	50/9376	2.08599531615925	SRM/ODC1/AMD1/P4HA2/CKB/GAMT/P4HA1/ALDH1B1/ALDH3A2/NOS2/PYCR1/ALDH2/ALDH9A1/SAT2/ARG2/MAOA/LAP3/ALDH18A1/GOT1	3.63373931760235
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	45/1708	157/9376	1.57341249123644	NDUFA4/LEP/UQCRH/NDUFV3/COX5A/CYC1/CYCS/CDC42/XBP1/TGFB1/NDUFC1/NDUFA6/COX8C/INSR/COX8A/NDUFB11/UQCRFS1/COX7B/NDUFV2/NDUFS6/NDUFS7/COX5B/NDUFA3/EIF2S1/MAPK13/PPARG/NDUFA12/NDUFS2/NDUFA9/COX6A1/MLX/UQCRC1/ADIPOR2/ITCH/COX7A2L/PIK3CB/BID/AKT1/SOCS3/NDUFS3/FOS/ERN1/SDHA/SREBF1/TNFRSF1A	3.41950771086739
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	18/1708	47/9376	2.10234690318401	LDHA/PKM/ACAT2/ACAT1/MDH2/GLO1/ALDH1B1/MDH1/FH/ALDH3A2/PCK2/ALDH2/ADH5/ACSS2/ALDH9A1/DLAT/PC/PDHB	3.57551157301955
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	78/1708	308/9376	1.39018826606649	GPX3/TUBA1C/TUBA1B/TUBB/NDUFA4/UQCRH/TUBB4B/NDUFV3/TUBB6/POLR2H/COX5A/PPIF/CYC1/CYCS/NDUFC1/NDUFA6/PSMA7/COX8C/COX8A/NDUFB11/VDAC1/POLR2I/UQCRFS1/COX7B/NDUFV2/NDUFS6/VDAC3/NDUFS7/TFAM/COX5B/NDUFA3/PSMA4/PPARG/POLR2L/KIF5B/NDUFA12/NDUFS2/PSMC5/HDAC1/PSMC4/SLC1A2/NDUFA9/COX6A1/POLR2D/TBPL1/PSMB3/PSMD2/AP2S1/UQCRC1/CREB1/VDAC2/CREB3L2/PSMB6/DNALI1/COX7A2L/TAF4B/HDAC2/GPX7/DNAH14/PSMD14/GPX8/PSMD11/TGM2/RB1CC1/REST/NDUFS3/PSMD12/ERN1/POLR2J3/SDHA/APAF1/EP300/DCTN2/AP2A1/GNAQ/IFT57/ATG2A/SP1	3.28611173817568
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/1708	23/9376	2.62539456267183	ACAT2/ACAT1/HMGCR/HMGCS1/MVD/FDPS/NUS1/IDI1/PDSS1/ZMPSTE24/FNTB	3.68328880235722
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	21/1708	59/9376	1.95387607668797	TK1/RRM2/TYMS/DTYMK/DUT/NME1/NT5C/NT5C3B/HDDC2/NME2/CTPS1/RRM1/NME1-NME2/UCK2/UMPS/NT5M/UCK1/NME6/CAD/CANT1/DCTD	3.46871352838234
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/1708	63/9376	1.91695476004609	POLR2H/POLD2/RPA3/POLR2I/POLR2L/PCNA/POLE4/POLR2D/LIG1/POLD1/RFC4/CUL4B/RFC3/ERCC1/GTF2H3/POLR2J3/RFC2/CUL4A/POLE/POLE2/RFC5/POLD3	3.44637000537396
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	23/1708	67/9376	1.88444195882415	LDHA/PKM/ENO1/GAPDH/TPI1/PFKP/GPI/PGAM1/PGK1/ALDH1B1/ALDH3A2/G6PC3/PCK2/HK1/HK2/ALDH2/ADH5/ACSS2/PGM1/ALDH9A1/DLAT/PFKL/PDHB	3.4288125496102
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	10/1708	20/9376	2.74473067915691	SQLE/EBP/LBR/MSMO1/DHCR7/FDFT1/DHCR24/TM7SF2/HSD17B7/SC5D	3.68626716852576
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	13/1708	30/9376	2.37876658860265	IDH3G/MDH2/CS/ACLY/MDH1/FH/PCK2/SUCLG2/IDH3A/DLAT/PC/SDHA/PDHB	3.56966128396689
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	33/1708	110/9376	1.64683840749415	LDHA/ENO1/GAPDH/RPS6/TIMP1/EIF4EBP1/SLC2A1/PFKP/EGLN3/MAP2K2/INSR/IGF1/PGK1/RPS6KB2/EIF4E/MKNK1/HIF1A/ERBB2/NOS2/HK1/HK2/PIK3CB/AKT1/EGLN1/PFKL/EP300/PDHB/MKNK2/PDK1/ARNT/VHL/MAPK1/CUL2	3.22058312591506
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	13/1708	31/9376	2.3020321825187	ACAT2/PCCA/ACAT1/SHMT1/MDH2/CS/MDH1/GLDC/PCCB/SHMT2/ACSS2/PGP/HYI	3.42690000555109
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	43/1708	154/9376	1.53277167797074	ALAS2/DHFR/NME1/UROS/MTHFD1L/AK1/AK2/RDH11/HMBS/VKORC1/SHMT1/MTHFD2/NME2/AK5/CTPS1/GCH1/GGCX/ADSL/ALDH1B1/MAT2A/COQ2/PDXK/MMAB/VKORC1L1/NME1-NME2/GUSB/ALDH3A2/MTHFD2L/COQ3/CPOX/SHMT2/ALDH2/UGDH/PANK3/GGH/UMPS/LIAS/MTHFD1/PTS/NME6/CAD/RDH13/FPGS	3.14613569798395
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	15/1708	39/9376	2.11133129165916	TYMS/AHCY/DHFR/MTHFD1L/CBS/SHMT1/MTHFD2/MAT2A/GLDC/AHCYL1/MTHFD2L/GART/SHMT2/ATIC/MTHFD1	3.28216708819906
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	39/1708	138/9376	1.55136951430608	CALM3/CALM1/PYGL/RPS6/EIF4EBP1/PPP1CC/GRB2/PPP1CB/PPP1CA/CBLB/MAP2K2/INSR/SH2B2/RPS6KB2/FASN/EIF4E/MKNK1/GYS1/FOXO1/PPP1R3B/PRKAR2A/PRKCZ/PRKAR1A/G6PC3/PCK2/HK1/HK2/PIK3CB/CRKL/AKT1/TRIP10/SOCS3/BRAF/MKNK2/SREBF1/CRK/RAF1/INPP5A/MAPK1	3.07951152266825
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	35/1708	122/9376	1.57484547164741	LEP/CCNA2/EIF4EBP1/SCD/EEF2/PFKP/HMGCR/INSR/IGF1/PPARG/RPS6KB2/FASN/GYS1/PPP2R1A/FOXO1/ELAVL1/G6PC3/PCK2/CAB39L/RAB10/PPP2R5C/PPP2R1B/CREB1/ADIPOR2/CREB3L2/PIK3CB/AKT1/FOXO3/PFKL/TBC1D1/PPP2R5E/PPP2R3A/SREBF1/EEF2K/PPP2R5A	3.01616295506391
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/1708	204/9376	1.42618358818937	CAV1/ACTG1/RPS6/CD63/MMP2/PPP1CC/ACTB/COL1A1/IQGAP1/GRB2/EIF4B/CDC42/PPP1CB/PPP1CA/TGFB1/DDX5/DCN/ITGA5/MAP2K2/LUM/RHOA/SDC4/IGF1/COL1A2/PPP1R12A/FLNA/FGFR1/MAPK13/RPS6KB2/FZD3/ITGAV/HIF1A/WNT7A/ERBB2/ITGB1/PXN/RDX/PIK3CB/ROCK1/AKT1/TIAM1/CTTN/ANK3/BRAF/MYC/CAV2/ARHGEF1/GPC1/VAV2/MSN/ITGB5/RAF1/MAPK1	2.90447940611077
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1708	110/9376	1.59693421332766	ID3/ID4/ID1/TGFB1/LRRC32/DCN/RHOA/BMP4/RPS6KB2/TFDP1/ID2/PPP2R1A/HDAC1/ZFYVE16/PPP2R1B/HDAC2/ROCK1/BMPR2/ACVR2B/TGIF2/CUL1/MYC/EP300/FST/SMAD5/BAMBI/LEMD3/E2F5/ACVR1/SP1/RBL1/MAPK1	2.97211209546464
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	32/1708	110/9376	1.59693421332766	CCNB1/CCNB2/CDK1/CCNA2/HSP90AB1/HSP90AA1/MAD2L1/AURKA/ANAPC11/IGF1/PLK1/MAPK13/PKMYT1/CDC25A/GNAI3/ANAPC5/BUB1/CDC25C/CDC25B/CDC26/ANAPC7/PIK3CB/AKT1/MAD2L2/STK10/CDC27/BRAF/ANAPC10/ANAPC1/KIF22/RAF1/MAPK1	2.97211209546464
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	53/1708	205/9376	1.41922659507626	NDUFA4/GAPDH/UQCRH/MMP2/NDUFV3/PPP1CC/COL1A1/COX5A/PPIF/CYC1/SLC2A1/PPP1CB/CYBA/PPP1CA/TGFB1/NDUFC1/NDUFA6/COX8C/PDK3/COL3A1/INSR/COX8A/NDUFB11/VDAC1/UQCRFS1/COX7B/NDUFV2/COL1A2/NDUFS6/VDAC3/NDUFS7/COX5B/NDUFA3/MAPK13/PTEN/NDUFA12/ATP2A2/NDUFS2/GYS1/NDUFA9/COX6A1/PRKCZ/UQCRC1/VDAC2/COX7A2L/PIK3CB/AKT1/G6PD/NDUFS3/SDHA/PDHB/SP1/GFPT1	2.86421707126508
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	80/1708	333/9376	1.31878951551083	HLA-G/CCNE1/PKM/HLA-C/CCNA2/EIF4EBP1/LAMA4/COL1A1/ISG15/GRB2/CDC42/COL6A2/COL4A1/COL6A3/COL4A2/ITGA5/MAP2K2/COL6A1/JAK1/COL1A2/ATP6V0B/HLA-E/RPS6KB2/PTEN/HEY1/COL9A3/FZD3/LAMB1/CHD4/ITGAV/WNT7A/LAMA1/ITGB1/BAK1/E2F1/TCF7L2/PPP2R1A/HDAC1/FOXO1/MX1/PXN/ATP6V1A/TUBG1/TBPL1/CCNE2/PRKCZ/LAMC1/PPP2R5C/DVL3/CSNK1A1/PPP2R1B/CREB1/CREB3L2/AXIN2/PIK3CB/HDAC2/DLG3/ATM/AKT1/APC/CCND2/LAMA5/IFNAR1/CDK4/PPP2R5E/EP300/CCND3/PPP2R3A/RFNG/AXIN1/STAT2/NFX1/ITGB5/RBL1/PPP2R5A/RAF1/EIF2AK2/MAML1/TNFRSF1A/MAPK1	2.79549294328097
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	45/1708	170/9376	1.45309271249483	TUBA1C/TUBA1B/ACTG1/CLDN10/CLDN6/ACTB/JAM3/CLDN7/CDC42/CLDN3/RHOA/ACTR2/RAB13/RAB8B/MYL6B/ARPC1A/ARPC4/PCNA/EPB41L4B/ACTN1/ERBB2/ITGB1/CLDN4/CGNL1/PPP2R1A/ACTR3/ARHGAP17/PRKCZ/HSPA4/PPP2R1B/RDX/ACTN4/ROCK1/DLG3/MYH9/TIAM1/CTTN/CDK4/MPDZ/F11R/NF2/MSN/VASP/RAP2C/RAPGEF2	2.81361435945221
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	25/1708	83/9376	1.65345221635958	AURKB/EZH2/SUZ12/CBX3/TFDP1/PCGF6/HDAC1/WDR5/RNF2/UBE2D2/UBE2D3/RYBP/PCGF3/PHF19/HCFC1/HDAC2/MTF2/YY1/DCAF7/ASXL1/PCGF5/EP300/OGT/PCGF2/FOXK2	2.82204173496933
NA	NA	hsa04518	Integrin signaling	41/1708	154/9376	1.46147997201861	ACTG1/PGF/LAMA4/ACTB/COL1A1/CDC42/COL6A2/COL4A1/ITGAE/TGFB1/COL6A3/COL4A2/ITGA5/LIMS1/FLNB/COL6A1/IGF1/COL1A2/VCL/FLNA/COL9A3/LAMB1/ACTN1/TLN1/ITGAV/LAMA1/RAC3/ERBB2/ITGB1/FLT4/PXN/PARVA/LAMC1/C3/ACTN4/PIK3CB/AKT1/CCND2/LAMA5/CCND3/ITGB5	2.72514225869216
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	23/1708	75/9376	1.68343481654957	BIRC5/MGST1/TOP2A/CYCS/GSTO1/MGST3/GSTP1/GSTA4/ERBB2/BAK1/SLC31A1/BRCA1/REV3L/PIK3CB/TOP2B/BID/ERCC1/ATM/AKT1/MSH2/APAF1/XIAP/MAPK1	2.80447406598465
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1708	93/9376	1.59371458789756	ACTG1/ACTB/IQGAP1/CDC42/ACP1/RHOA/INSR/HEG1/VCL/FGFR1/ARHGAP29/CDH5/SNAI1/ACTN1/RAC3/ERBB2/TCF7L2/FYN/MYL5/ACTN4/ROCK1/EP300/FER/CTNND1/NLK/MAPK1/CSNK2A1	2.71558585744867
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	27/1708	93/9376	1.59371458789756	CCNE1/CKS1B/LAMA4/CYCS/COL4A1/CKS2/COL4A2/PTEN/LAMB1/ITGAV/LAMA1/ITGB1/BAK1/E2F1/CCNE2/LAMC1/NOS2/PIK3CB/TRAF4/E2F3/GADD45A/AKT1/LAMA5/CDK4/MYC/APAF1/XIAP	2.71558585744867
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1708	87/9376	1.57743142480282	BIRC5/CYCS/GRB2/TGFB1/RALB/MAP2K2/RHOA/RPS6KB2/RAC3/BAK1/TCF7L2/RALA/AXIN2/PIK3CB/GADD45A/AKT1/APC/MSH2/BRAF/FOS/MYC/APPL1/AXIN1/RAF1/MAPK1	2.5536659125962
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	34/1708	128/9376	1.45813817330211	RRM2/NME1/IMPDH2/GMPS/NT5C/AK1/PAICS/AK2/ADA/PRPS2/HPRT1/HDDC2/NUDT5/PDE4D/NME2/ADK/AK5/RRM1/IMPDH1/ADSL/ITPA/NME1-NME2/PAPSS1/GART/ATIC/PGM1/NUDT16/NT5M/PFAS/PDE4C/PDE6H/NME6/PRPS1/CANT1	2.46300942331297
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/1708	30/9376	2.0128024980484	ABCG2/TYMS/DHFR/SHMT1/SLC19A1/GART/SHMT2/GGH/ATIC/ABCC5/FPGS	2.62217107338843
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	56/1708	233/9376	1.31935551959474	ENO1/ACTG1/TPM2/MYL4/TPM1/DSC2/ACTB/COL1A1/TNNI2/LMNB1/LMNB2/ATP1A1/VCAN/TPM4/LBR/COL6A2/COL4A1/DSP/COL6A3/DCN/COL4A2/SPTBN1/ITGA5/COL27A1/NID1/COL3A1/COL6A1/TPM3/DSG2/DIAPH3/SDC4/DIAPH1/COL1A2/VCL/DAG1/SGCB/COL9A3/SYNE2/ATP1B3/TLN1/ITGAV/INF2/LAMA1/ITGB1/PKP2/MYL5/COL5A2/COL5A1/MYH9/PLEC/FBLN2/JUP/TMOD3/ANK3/ITGB5/SUN2	2.32968147664238
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/1708	116/9376	1.46701122506662	ACTG1/CLDN10/MMP2/CLDN6/ACTB/JAM3/CLDN7/CDC42/CLDN3/CYBA/RHOA/THY1/VCL/MAPK13/CDH5/GNAI3/ACTN1/ITGB1/CLDN4/PXN/PTK2B/MYL5/ACTN4/PIK3CB/ROCK1/F11R/VAV2/MSN/CTNND1/VASP/ARHGAP5	2.38857751605828
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	49/1708	200/9376	1.34491803278689	TUBA1C/TUBA1B/TUBB/ACTG1/CLDN10/GAPDH/TMBIM6/TUBB4B/CLDN6/ACTB/TUBB6/CLDN7/NCL/CYCS/PYCARD/MYO1B/CDC42/TMED10/CLDN3/MYO10/IL1R1/RHOA/ACTR2/ARPC1A/BAIAP2L1/MAPK13/ARPC4/NCKAP1/ITGB1/BAK1/CLDN4/ACTR3/FYN/MYO1E/BRK1/ABCF2/ROCK1/MYH9/IRAK1/CTTN/FOS/WIPF1/MYO6/ARHGEF1/WIPF2/TAB2/ABL1/TNFRSF1A/MAPK1	2.32698034567381
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	22/1708	77/9376	1.5684175309468	GRB2/TGFB1/MAP2K2/CTBP2/BAK1/E2F1/HDAC1/PIK3CB/HDAC2/CTBP1/E2F3/GAB2/GADD45A/CRKL/AKT1/CDK4/BRAF/MYC/ABL1/CRK/RAF1/MAPK1	2.36365029108185
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	23/1708	82/9376	1.53972696635631	TK1/RRM2/MGST1/DUT/NME1/IMPDH2/GMPS/GSTO1/MGST3/HPRT1/GSTP1/NME2/GSTA4/RRM1/IMPDH1/ITPA/NME1-NME2/GUSB/UCK2/UMPS/TPMT/UCK1/NME6	2.31669162485706
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	64/1708	275/9376	1.27754737066212	TUBA1C/TUBA1B/TUBB/HSPA5/CAV1/NDUFA4/UQCRH/TUBB4B/NDUFV3/HSPA8/TUBB6/COX5A/PPIF/CYC1/CYCS/CYBA/NDUFC1/NDUFA6/PSMA7/STIP1/COX8C/COX8A/NDUFB11/VDAC1/UQCRFS1/COX7B/NDUFV2/NDUFS6/VDAC3/NDUFS7/COX5B/NDUFA3/PSMA4/EIF2S1/MAPK13/KIF5B/NDUFA12/PPP3CA/NDUFS2/PSMC5/EGR1/PSMC4/FYN/NDUFA9/COX6A1/PSMB3/LAMC1/PSMD2/UQCRC1/CREB1/VDAC2/CREB3L2/PSMB6/COX7A2L/PIK3CB/PSMD14/PSMD11/NDUFS3/PSMD12/SDHA/APAF1/CAV2/MAPK1/CSNK2A1	2.20468946279214
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/1708	78/9376	1.54830961388338	CAV1/ACTG1/ACTB/CDC42/ITGA5/RHOA/ACTR2/ARPC1A/VCL/ARPC4/ITGB1/ACTR3/ELMO1/PXN/DNM2/PIK3CB/CRKL/CTTN/MAD2L2/CAV2/ARHGAP10/CRK	2.29491661607699
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	39/1708	156/9376	1.37236533957845	CLDN10/CLDN6/CLDN7/CYCS/GRB2/CLDN3/CD81/YWHAB/YWHAQ/MAP2K2/JAK1/LDLR/EIF2S1/YWHAH/BAK1/CLDN4/E2F1/OAS3/PPP2R1A/MX1/YWHAE/PPP2R1B/PSME3/PIK3CB/E2F3/BID/AKT1/SOCS3/IRF7/IFNAR1/CDK4/BRAF/MYC/APAF1/STAT2/RAF1/EIF2AK2/TNFRSF1A/MAPK1	2.21337299669203
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	105/1708	480/9376	1.20081967213115	GPX3/TUBA1C/TUBA1B/TUBB/CALM3/HSPA5/CALM1/NDUFA4/UQCRH/TUBB4B/NDUFV3/TUBB6/COX5A/PPIF/CYC1/CYCS/FUS/TOMM40/XBP1/NDUFC1/NDUFA6/PSMA7/UBE2L3/DKK1/COX8C/MAP2K2/COX8A/NDUFB11/PARK7/VDAC1/UQCRFS1/SIGMAR1/COX7B/NDUFV2/NDUFS6/UBA1/HTRA2/VDAC3/NDUFS7/COX5B/NDUFA3/PSMA4/EIF2S1/MAPK13/HSD17B10/KIF5B/NDUFA12/ATP2A2/PPP3CA/CSNK1E/FZD3/NDUFS2/WNT7A/DERL1/PSMC5/BAK1/PSMC4/NDUFA9/COX6A1/TARDBP/PSMB3/SNCA/NOS2/PSMD2/DVL3/CSNK1A1/UQCRC1/ATXN3/UBE2J2/VDAC2/AXIN2/PSMB6/DNALI1/COX7A2L/GPX7/PPID/DNAH14/PSMD14/GPX8/BID/PSMD11/APC/RB1CC1/NDUFS3/UBE2G1/CCS/BRAF/PSMD12/ATF6/TANK/ERN1/SDHA/APAF1/DCTN2/GNAQ/VAPB/IFT57/MFN1/ATG2A/AXIN1/RAF1/FRAT2/TNFRSF1A/MAPK1/CSNK2A1	2.13166033705707
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	44/1708	180/9376	1.34186833203227	HLA-G/HLA-C/CALR/SRSF3/SRSF7/EIF4EBP1/SRSF2/PPP1CC/CYCS/PPP1CB/PDIA3/SRSF5/PPP1CA/ALYREF/SRSF6/ITGA5/SRSF9/SRSF1/JAK1/HLA-E/EIF2S1/SRPK1/TAP1/BAK1/OAS3/SRSF4/ZC3HAV1/C3/HCFC1/POU2F1/PIK3CB/BID/AKT1/SOCS3/IRAK1/IRF7/IFNAR1/EIF2B2/APAF1/TAB2/STAT2/PML/EIF2AK2/TNFRSF1A	2.18566784757071
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1708	28/9376	1.96052191368351	HSD17B12/ELOVL6/ACOT4/ELOVL1/ELOVL5/THEM4/HADH/ELOVL2/PPT2/ACOT7	2.40223483567877
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/1708	70/9376	1.5684175309468	GRB2/CDC42/SLC2A1/EGLN3/TGFB1/MAP2K2/HIF1A/FH/PIK3CB/CRKL/AKT1/EGLN1/BRAF/EP300/ARNT/CRK/VHL/RAF1/MAPK1/CUL2	2.25280436534397
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1708	49/9376	1.68044735458586	GALNT1/GALNT2/B4GALT1/COLGALT1/GXYLT1/POGLUT1/POFUT1/B4GALT2/FUT11/OGT/RFNG/POMT1/PLOD3/GALNT6/B4GALT3	2.25377263213993
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	36/1708	144/9376	1.37236533957845	ID3/GRB2/ID4/ID1/MAP2K2/IGF1/JAK1/LIFR/BMP4/FGFR1/MAPK13/ID2/FZD3/WNT7A/PCGF6/FGFR3/RIF1/PCGF3/DVL3/AXIN2/PIK3CB/BMPR2/AKT1/APC/REST/ACVR2B/TCF3/MYC/PCGF5/PCGF2/SMAD5/AXIN1/ACVR1/TBX3/RAF1/MAPK1	2.1251574737322
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	12/1708	37/9376	1.78036584593962	GPI/PGM3/GNPNAT1/NAGK/HK1/HK2/UGDH/PGM1/GNE/NANS/UAP1/GFPT1	2.24459218807326
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/1708	54/9376	1.62650706913002	LDHA/PHGDH/SRM/MPST/AHCY/TST/AMD1/CBS/MDH2/MAT2A/DNMT3B/MDH1/AHCYL1/ADI1/MRI1/GOT1	2.17899796956952
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1708	14/9376	2.35262629642021	B4GALT1/B3GNT7/ST3GAL1/B4GALT4/B4GALT2/B4GALT3	2.39026496005228
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	54/1708	232/9376	1.27771945409029	ACTG1/PPP1CC/ACTB/IQGAP1/CDC42/PPP1CB/PPP1CA/ITGAE/ITGA5/MAP2K2/RHOA/FGF7/ACTR2/PFN1/DIAPH3/DIAPH1/ARPC1A/PPP1R12A/VCL/CFL1/FGFR1/ARPC4/NCKAP1/ACTN1/ITGAV/RAC3/ITGB1/ACTR3/ENAH/FGFR3/PXN/BRK1/GNG12/MYL5/RDX/ACTN4/PIK3CB/ROCK1/CRKL/AKT1/MYH9/APC/TIAM1/PIP4K2A/ABI2/BRAF/PIP5K1C/ARHGEF1/CRK/VAV2/MSN/ITGB5/RAF1/MAPK1	2.02148585101532
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/1708	59/9376	1.58170920493788	GPX3/RRM2/SRM/MGST1/ODC1/GSTO1/MGST3/GSTP1/GSTA4/RRM1/ANPEP/GGCT/GPX7/GPX8/G6PD/TXNDC12/LAP3	2.1153508700613
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/1708	59/9376	1.58170920493788	GRB2/MAP2K2/PTEN/ERBB2/BAK1/TCF7L2/AXIN2/PIK3CB/GADD45A/AKT1/APC/FOXO3/BRAF/MYC/AXIN1/RAF1/MAPK1	2.1153508700613
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	41/1708	170/9376	1.32392891582863	ACTG1/MGST1/ACTB/GRB2/GSTO1/TGFB1/MGST3/MAP2K2/GSTP1/RPS6KB2/PTEN/SMARCC1/GSTA4/FZD3/WNT7A/BAK1/E2F1/TCF7L2/SMARCA4/SMARCB1/PBRM1/DVL3/CSNK1A1/TXNRD1/ARID1A/AXIN2/PIK3CB/E2F3/GADD45A/AKT1/APC/CDK4/ACTL6A/BRAF/MYC/SMARCD1/AXIN1/RAF1/ARID2/FRAT2/MAPK1	2.01153323344966
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	21/1708	77/9376	1.49712582499468	RALBP1/CDC42/TGFB1/RALB/JAK1/RPS6KB2/RAC3/ERBB2/BAK1/E2F1/RALA/RAD51/BRCA2/PIK3CB/E2F3/GADD45A/AKT1/CDK4/BRAF/RAF1/MAPK1	2.06719803134105
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	57/1708	248/9376	1.2616907154189	TUBA1C/TUBA1B/TUBB/DYNLL1/ACTG1/GAPDH/HSP90B1/HSP90AB1/TUBB4B/HSP90AA1/ACTB/TUBB6/CYCS/PYCARD/CDC42/CSE1L/MAP2K2/RHOA/ACTR2/PFN1/DYNLT3/ARPC1A/TXN2/FLNA/MAPK13/ARPC4/FBXO22/NCKAP1/KIF5B/BAK1/TCF7L2/ACTR3/ELMO1/DNM2/PIK3C2G/RALA/BRK1/GSDMD/DYNC1LI1/KPNA4/MYL5/PIK3CB/AHNAK/AKT1/PKN1/VPS16/IRAK1/RIPK2/FOS/MYC/DCTN2/MYO6/TAB2/DYNC1H1/RAF1/TNFRSF1A/MAPK1	1.97112814206893
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	35/1708	142/9376	1.35303625028862	CALM3/CALM1/CAV1/ACTG1/MGST1/HSP90B1/MMP2/HSP90AB1/HSP90AA1/ACTB/CYBA/GSTO1/IL1R1/MGST3/RHOA/SUMO2/GSTP1/SDC4/TXN2/BMP4/MAPK13/GSTA4/CDH5/ITGAV/RAC3/PRKCZ/PIK3CB/BMPR2/AKT1/ACVR2B/FOS/CAV2/GPC1/ACVR1/TNFRSF1A	2.00058522947158
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	20/1708	73/9376	1.50396201597639	RAN/PPIA/XPO1/CHMP4A/MAP1B/CPSF6/PIN1/MX1/SMARCB1/FURIN/CCNT1/NUP153/NELFCD/BICD2/NELFE/TNPO3/CCNT2/RANBP2/EP300/TRIM5	2.04002854075337
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	48/1708	205/9376	1.28533729365397	HLA-G/CCNE1/PKM/HLA-C/CDC20/CDK1/CCNA2/RANBP1/GRB2/CDC42/YWHAB/YWHAQ/RHOA/JAK1/VDAC3/HLA-E/HNRNPK/CHD4/ACTN1/YWHAH/CHEK1/BAK1/HDAC1/PXN/TBPL1/CCNE2/YWHAE/REL/C3/DDX3X/LYN/CREB1/CREB3L2/ACTN4/PIK3CB/HDAC2/CCND2/IRF7/CDK4/GTF2H3/EP300/CCND3/HDAC5/RBL1/SRF/EIF2AK2/MAPK1/HDAC3	1.94946589064468
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1708	30/9376	1.82982045277127	GPAA1/PIGK/PIGF/PIGX/PIGG/PIGT/PIGH/PGAP1/PIGW/PIGS	2.1484259680992
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	34/1708	138/9376	1.35247598683094	ACTG1/ACTB/PYCARD/CDC42/ITGA5/MAP2K2/RHOA/ACTR2/ARPC1A/MAPK13/ARPC4/RAC3/ITGB1/ACTR3/ELMO1/PXN/PTK2B/PIK3CB/ROCK1/PKN2/CRKL/AKT1/PKN1/IRAK1/FOS/PIP5K1C/WIPF1/GNAQ/ARHGEF1/WIPF2/TAB2/CRK/VAV2/MAPK1	1.96865048709817
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/1708	48/9376	1.60109289617486	ACAT2/PCCA/ACAT1/HMGCS1/HSD17B10/HADH/ALDH1B1/AACS/ALDH3A2/PCCB/ALDH2/ALDH9A1/MCCC2/OXCT1	1.97040937281394
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/1708	27/9376	1.82982045277127	SCD/HSD17B12/ELOVL6/ACOT4/FADS1/ELOVL1/ELOVL5/ELOVL2/ACOT7	2.0378487917405
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/1708	12/9376	2.28727556596409	VKORC1/GGCX/COQ2/VKORC1L1/COQ3	2.10581379160688
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	10/1708	32/9376	1.71545667447307	AKR1B1/PFKP/B4GALT1/G6PC3/HK1/HK2/PGM1/B4GALT2/PFKL/GLA	1.91328837645246
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	15/1708	54/9376	1.52485037730939	UBE2T/FANCI/RPA3/RAD51C/RAD51/BRCA1/REV3L/FANCG/USP1/BRCA2/FANCD2/ERCC1/RMI1/FANCE/FANCA	1.82543495969337
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1708	24/9376	1.82982045277127	B4GALT7/XYLT1/HS6ST1/B3GALT6/HS3ST3B1/HS3ST1/HS2ST1/EXT2	1.92099407711971
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	78/1708	362/9376	1.18281211587977	CCNE1/RPS6/HSP90B1/HSP90AB1/PGF/EIF4EBP1/HSP90AA1/LAMA4/COL1A1/GRB2/EIF4B/YWHAB/YWHAQ/COL6A2/COL4A1/COL6A3/COL4A2/ITGA5/MAP2K2/COL6A1/FGF7/INSR/GNB2/IGF1/JAK1/COL1A2/FGFR1/GNB1/RPS6KB2/THEM4/PTEN/EIF4E/DDIT4/COL9A3/LAMB1/SGK2/ITGAV/GNB5/LAMA1/YWHAH/ERBB2/ITGB1/GYS1/FLT4/PPP2R1A/FGFR3/NR4A1/CCNE2/YWHAE/LAMC1/G6PC3/PCK2/PPP2R5C/GNG12/BRCA1/PPP2R1B/CREB1/CREB3L2/PIK3CB/IL2RB/PKN2/AKT1/PKN1/CCND2/LAMA5/IFNAR1/CDK4/FOXO3/GNG11/MYC/PPP2R5E/CCND3/PPP2R3A/EFNA4/ITGB5/PPP2R5A/RAF1/MAPK1	1.67412932149909
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	12/1708	41/9376	1.60667161706746	POLD2/SSBP1/RPA3/RAD51C/RAD51/POLD1/BRCA1/XRCC2/BRCA2/ATM/BARD1/POLD3	1.83728683693195
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/1708	227/9376	1.23331510693394	NDUFA4/UQCRH/MGST1/NDUFV3/COX5A/PPIF/CYC1/GRB2/CYBA/GSTO1/ACP1/NDUFC1/NDUFA6/MGST3/COX8C/MAP2K2/COX8A/NDUFB11/VDAC1/UQCRFS1/COX7B/NDUFV2/NDUFS6/VDAC3/NDUFS7/COX5B/NDUFA3/MAPK13/PTEN/NDUFA12/GSTA4/NDUFS2/HIF1A/PRKD3/NDUFA9/COX6A1/CBR1/UQCRC1/VDAC2/COX7A2L/PIK3CB/AKT1/NDUFS3/FOXO3/BRAF/FOS/SDHA/ARNT/ABL1/RAF1/MAPK1	1.67941293537023
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/1708	37/9376	1.63200202544465	MAP2K2/TPM3/PPARG/BAK1/TCF7L2/NCOA4/GADD45A/BRAF/MYC/TPR/MAPK1	1.81784840602737
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	30/1708	125/9376	1.31747072599532	MAP2K2/RHOA/ORMDL2/MAPK13/PTEN/GNAI3/RAC3/CERS4/PPP2R1A/FYN/CERS5/PRKCZ/SMPD2/PPP2R5C/SPTLC2/PPP2R1B/PIK3CB/ROCK1/GAB2/BID/AKT1/SGPP1/PPP2R5E/PPP2R3A/GNAQ/PPP2R5A/RAF1/SPTLC1/TNFRSF1A/MAPK1	1.68637001088325
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	26/1708	106/9376	1.34647165392603	CCNE1/HSP90B1/HSP90AB1/HSP90AA1/ETV5/GRB2/MAP2K2/GSTP1/IGF1/FGFR1/PTEN/ERBB2/SLC19A1/E2F1/TCF7L2/FOXO1/CCNE2/CREB1/CREB3L2/PIK3CB/E2F3/AKT1/BRAF/EP300/RAF1/MAPK1	1.69304808964717
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/1708	46/9376	1.55136951430608	PSMA7/PSMA4/PSMC5/PSMC4/PSMB3/PSMD2/PSME3/PSMF1/PSMB6/PSMD14/PSMD11/PSMD12/PSME4	1.76916917213538
Cellular Processes	Cell motility	hsa04814	Motor proteins	44/1708	194/9376	1.24503247301963	TUBA1C/TUBA1B/TUBB/DYNLL1/ACTG1/TPM2/MYL4/TPM1/TUBB4B/ACTB/TUBB6/TNNI2/MYO1B/TPM4/MYO10/CENPE/KIF11/TPM3/KIF4A/KIF2C/MYL6B/DYNLT3/KIF20B/KIF23/KIFC1/KIF5B/MYO19/ACTA2/KIF21A/KIF18A/MYO1E/TUBG1/MYO7A/DYNC1LI1/MYL5/DNALI1/DNAH14/MYH9/KIF2A/DCTN2/MYO6/KIF9/DYNC1H1/KIF22	1.62758764039317
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1708	13/9376	2.11133129165916	XRCC5/PRKDC/XRCC6/FEN1/DCLRE1C	1.89232717714989
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1708	38/9376	1.58905460372242	GPI/PGM3/GNPNAT1/NAGK/HK1/HK2/UGDH/PGM1/GNE/UAP1/GFPT1	1.71715278009346
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1708	21/9376	1.82982045277127	DSEL/CHSY1/CHST12/B4GALT7/CSGALNACT1/XYLT1/B3GALT6	1.79663727381922
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/1708	70/9376	1.41157577785212	HLA-G/HLA-C/CAV1/ACTG1/ACTB/CYCS/CD55/HLA-E/EIF4G1/DAG1/SGCB/EIF4G2/LAMA1/RAC3/FYN/BID/EIF4G3/ABL1	1.63119477942681
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1708	34/9376	1.61454745832759	POLR2H/POLR2I/POLR1D/POLR2L/POLR2D/POLR1E/POLR3H/POLR2J3/POLR1A/POLR3D	1.69419530218637
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	36/1708	157/9376	1.25872999298916	BIRC5/ACTG1/PPP1CC/ACTB/TEAD4/PPP1CB/ID1/YWHAB/YWHAQ/PPP1CA/TGFB1/WWTR1/BMP4/ID2/CSNK1E/FZD3/WNT7A/YWHAH/TCF7L2/PPP2R1A/MOB1A/PRKCZ/YWHAE/DVL3/PPP2R1B/MOB1B/AXIN2/DLG3/BMPR2/APC/CCND2/MYC/CCND3/TP53BP2/AXIN1/NF2	1.54291931128209
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	31/1708	133/9376	1.27949851208818	CCNB1/CCNB2/GRB2/TGFB1/BNIP3/MAP2K2/INSR/IGF1/PLK1/PRMT1/ATG12/MAPK13/PTEN/CSNK1E/SGK2/FOXO1/G6PC3/PCK2/PIK3CB/GADD45A/ATM/AKT1/CCND2/CCNG2/FOXO3/BRAF/EP300/CDKN2D/RAF1/NLK/MAPK1	1.53210088520409
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	26/1708	109/9376	1.30941280106568	PYGL/PPP1CC/SLC2A1/PPP1CB/PPP1CA/INSR/RPS6KB2/PTEN/GYS1/FOXO1/PPP1R3B/PRKCZ/G6PC3/PCK2/MLX/CREB1/CREB3L2/PIK3CB/SLC27A5/AKT1/SOCS3/SLC27A6/OGT/SREBF1/GFPT1/TNFRSF1A	1.53345298115642
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	34/1708	148/9376	1.26109247420723	GRB2/MAP2K2/FGF7/IGF1/FGFR1/RPS6KB2/PTEN/HEY1/FZD3/WNT7A/ERBB2/BAK1/E2F1/TCF7L2/FLT4/BRCA1/DVL3/CSNK1A1/BRCA2/AXIN2/PIK3CB/E2F3/GADD45A/AKT1/APC/CDK4/BRAF/FOS/MYC/AXIN1/SP1/RAF1/FRAT2/MAPK1	1.51098425145998
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1708	48/9376	1.48672911787666	CLDN10/EPCAM/CD63/CLDN6/CLDN7/CLDN3/CD81/CHMP4A/LDLR/TGOLN2/CLDN4/DPP4/CHMP7	1.595519797337
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	47/1708	214/9376	1.20562936374182	HLA-G/CALM3/CCNB1/HLA-C/CALM1/CALR/CCNB2/CDK1/CYCS/PDIA3/MAP2K2/GNB2/HLA-E/CFL1/MAPK13/GNB1/RPS6KB2/PPP3CA/GNAI3/GNB5/RAC3/CHEK1/TAP1/BAK1/CDC25C/PXN/PTK2B/GNG12/CUL4B/PIK3CB/BID/WEE1/CRKL/ATM/AKT1/IRAK1/CUL1/FOS/GNG11/CUL4A/GNAQ/TAB2/CRK/TRIM5/RAF1/TNFRSF1A/MAPK1	1.43610235358454
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1708	10/9376	2.19578454332553	MPST/TST/SELENBP1/PAPSS1	1.78551859726219
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1708	18/9376	1.82982045277127	CD320/MMAB/HCFC1/ZNF143/LMBRD1/ABCD4	1.66309625719276
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/1708	31/9376	1.59371458789756	PFKP/PGLS/PRPS2/GPI/RPIA/G6PD/PGM1/PFKL/PRPS1	1.56263458912829
NA	NA	hsa04981	Folate transport and metabolism	9/1708	31/9376	1.59371458789756	ABCG2/TYMS/DHFR/SHMT1/SLC19A1/SHMT2/ABCC5/MTHFD1/FPGS	1.56263458912829
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	10/1708	36/9376	1.52485037730939	PYGL/GPI/GYG2/GYS1/G6PC3/HK1/HK2/GYG1/PGM1/GBE1	1.48902450588805
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	49/1708	227/9376	1.18494980862281	HLA-G/CALM3/HLA-C/CALM1/CALR/EIF4EBP1/CYCS/GRB2/PDIA3/IL1R1/MAP2K2/RHOA/GNB2/JAK1/HLA-E/MAPK13/GNB1/RPS6KB2/PPP3CA/GNAI3/ITGAV/GNB5/RAC3/TAP1/BAK1/E2F1/CCL3L1/PXN/PTK2B/GNG12/CCR1/CREB1/CREB3L2/PIK3CB/ROCK1/E2F3/BID/CRKL/AKT1/CDK4/GNG11/MYC/GNAQ/ARHGEF1/CRK/SP1/RAF1/TNFRSF1A/MAPK1	1.33127728022914
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/1708	23/9376	1.67070563079116	B4GALT1/B3GALNT2/B4GALT2/POMGNT1/FUT4/POMT1/B4GALT3	1.51987867826392
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	11/1708	41/9376	1.47278231564517	MMP2/MAP2K2/ERBB2/E2F1/FGFR3/E2F3/CDK4/BRAF/MYC/RAF1/MAPK1	1.4318070943683
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	8/1708	28/9376	1.5684175309468	ST3GAL4/B4GALT1/B4GALT4/B4GALT2/ST8SIA1/FUT4/B4GALT3/B3GNT5	1.42159421310283
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1708	28/9376	1.5684175309468	AKR1B1/DHFR/GCH1/PCBD2/CBR1/GGH/PTS/FPGS	1.42159421310283
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	11/1708	42/9376	1.43771607003457	ACAT2/ACAT1/AADAT/HADH/GCDH/ALDH1B1/DHTKD1/ALDH3A2/ALDH2/ALDH9A1/MAOA	1.34175047442579
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1708	33/9376	1.49712582499468	AADAT/IDH3G/DHTKD1/CS/GPT2/IDH3A/DLAT/PDHB/GOT1	1.35010840054072
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1708	20/9376	1.64683840749415	UGDH/CYB5R2/GNE/NANS/UAP1/CYB5R3	1.36664025764673
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1708	57/9376	1.34828875467357	ACAT2/SCD/ACAT1/HSD17B12/ELOVL6/FADS1/ELOVL1/ELOVL5/FASN/HADH/ACSL4/CBR4/ELOVL2/PPT2	1.24474601249995
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	53/1708	253/9376	1.14996621340171	ACTG1/ACTB/CYCS/PYCARD/CDC42/IL1R1/UBE2V2/ITGA5/BNIP3/RHOA/ACTR2/VDAC1/PFN1/DIAPH1/ARPC1A/CBX3/VCL/ATG12/MAPK13/ARPC4/RPS6KB2/U2AF1/ACTN1/TLN1/FNBP1/ITGB1/ACTR3/FOXO1/ELMO1/UBE2D2/PXN/UBE2D3/UBE2N/C3/MYL5/HK1/HK2/ACTN4/PIK3CB/PPID/ROCK1/CRKL/ATM/AKT1/GLMN/CTTN/RIPK2/FOXO3/CUL1/TAB2/CRK/TNFRSF1A/MAPK1	1.1412304956667
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	15/1708	62/9376	1.32809548991463	CTBP2/HEY1/APH1B/HDAC1/NCOR2/TLE3/DVL3/ITCH/HDAC2/CTBP1/SPEN/ADAM17/EP300/RFNG/MAML1	1.22325361458204
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/1708	87/9376	1.26194513984226	TPM2/UQCRH/MYL4/TPM1/FXYD2/COX5A/CYC1/ATP1A1/TPM4/COX8C/TPM3/COX8A/UQCRFS1/COX7B/COX5B/ATP2A2/ATP1B3/COX6A1/UQCRC1/COX7A2L	1.15844123795971
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	35/1708	163/9376	1.17871869657045	CCNE1/BIRC5/CCNA2/CYCS/GRB2/YWHAB/YWHAQ/TGFB1/MAP2K2/JAK1/VDAC3/MAPK13/PCNA/E2F1/CCNE2/PTK2B/DDX3X/CREB1/CREB3L2/PIK3CB/E2F3/BID/AKT1/IRAK1/IRF7/IFNAR1/BRAF/FOS/MYC/APAF1/EP300/TAB2/STAT2/RAF1/MAPK1	1.0863049894707
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1708	68/9376	1.29163796666207	CCNA2/EIF4EBP1/GRB2/MAP2K2/DUSP6/RPS6KB2/TCF7L2/PIK3CB/AKT1/JUP/PPARD/BRAF/MYC/PML/RAF1/MAPK1	1.1390921263562
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	49/1708	235/9376	1.14461109173352	NDUFA4/ACTG1/UQCRH/RPS6/NDUFV3/ACTB/COX5A/CYC1/GRB2/NDUFC1/NDUFA6/COX8C/NDUFAF2/COX8A/NDUFB11/UQCRFS1/COX7B/NDUFV2/COA1/NDUFS6/NDUFS7/COX5B/NDUFA3/FGFR1/MAPK13/PPARG/RPS6KB2/NDUFA12/SMARCC1/KDM1A/NDUFS2/ACSL4/COA6/NDUFA9/SMARCA4/COA4/COX6A1/SMARCB1/UQCRC1/CREB1/ARID1A/CREB3L2/COX7A2L/NDUFS3/ACTL6A/SDHA/COA7/SMARCD1/NDUFAF6	1.05956401602125
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/1708	138/9376	1.19336116485083	NDUFA4/UQCRH/PPA1/NDUFV3/COX5A/CYC1/CYCS/NDUFC1/NDUFA6/COX8C/COX8A/NDUFB11/UQCRFS1/COX7B/NDUFV2/ATP6V0B/NDUFS6/NDUFS7/COX5B/NDUFA3/NDUFA12/NDUFS2/PPA2/NDUFA9/COX6A1/ATP6V1A/UQCRC1/COX7A2L/NDUFS3/SDHA	1.07996165864211
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1708	98/9376	1.23232806002963	CDC42/MYO10/MARCKSL1/ACTR2/ARPC1A/CFL1/ARPC4/RPS6KB2/ACTR3/DNM2/LYN/PIK3CB/GAB2/CRKL/AKT1/ASAP3/PIP5K1C/CRK/VAV2/RAF1/VASP/MAPK1	1.09112885039386
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	43/1708	205/9376	1.15144799223168	HLA-G/CCNE1/HLA-C/CALR/CCNA2/ISG15/CYCS/PDIA3/JAK1/HLA-E/MAPK13/TAP1/PSMC5/BAK1/E2F1/OAS3/HDAC1/PSMC4/SAP30/CCNE2/NCOR2/PSMD2/LYN/PIK3CB/HDAC2/PSMD14/E2F3/GADD45A/BID/PSMD11/AKT1/CCND2/IRAK1/IRF7/IFNAR1/CDK4/PSMD12/MYC/APAF1/CCND3/TAB2/STAT2/EIF2AK2	1.03471471002428
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	31/1708	144/9376	1.18175904241478	PPIF/CYCS/XBP1/NOP56/PSMA7/VDAC1/VDAC3/PSMA4/ATP2A2/PSMC5/PSMC4/TBPL1/PSMB3/AFG3L2/PSMD2/ATXN3/VDAC2/PSMB6/PIK3CB/PSMD14/PSMD11/AKT1/RB1CC1/ATXN10/PSMD12/ERN1/GNAQ/OPA1/PUM1/ATG2A/SP1	1.03733228190213
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1708	89/9376	1.23358682209299	LAMA4/HMMR/COL1A1/COL6A2/COL4A1/COL6A3/COL4A2/ITGA5/COL6A1/SDC4/COL1A2/DAG1/COL9A3/LAMB1/ITGAV/LAMA1/ITGB1/LAMC1/LAMA5/ITGB5	1.04494669818714
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	28/1708	130/9376	1.18234552332913	MMP2/COL1A1/GRB2/COL4A1/TGFB1/COL4A2/MAP2K2/COL3A1/GNB2/COL1A2/MAPK13/GNB1/RLN2/GNAI3/GNB5/ACTA2/PRKCZ/NOS2/GNG12/CREB1/CREB3L2/PIK3CB/AKT1/EDNRB/FOS/GNG11/RAF1/MAPK1	0.988048712355941
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1708	80/9376	1.23512880562061	RPS6/EIF4EBP1/GRB2/MAP2K2/IGF1/JAK1/RPS6KB2/PTEN/EIF4E/ERBB2/FGFR3/PIK3CB/AKT1/FOXO3/BRAF/NF1/RAF1/MAPK1	0.996761587337501
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/1708	136/9376	1.17054690728751	CCNE1/HSPA8/CYCS/CBLB/JAK1/EIF2S1/BAK1/OAS3/MX1/CCNE2/PIK3CB/IL2RB/BID/AKT1/RCHY1/CCND2/IRAK1/IRF7/IFNAR1/CDK4/FOS/APAF1/CCND3/TAB2/ADAR/STAT2/MSN/EIF2AK2/CSNK2A1	0.945509367969908
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1708	41/9376	1.33889301422288	PHGDH/ALAS2/CBS/SHMT1/PGAM1/GAMT/GLDC/GCAT/SHMT2/MAOA	1.02632735180466
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/1708	27/9376	1.42319368548877	ACAT2/ACAT1/HMGCS1/HADH/AACS/OXCT1/L2HGDH	1.03926667240534
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/1708	61/9376	1.25987637731793	MT1G/MT1E/FXYD2/ATP1A1/SLC39A4/MT1H/MT1X/MT1F/ATP1B3/SLC31A1/ATP2B4/MT1M/SLC30A1/TRPM7	0.961012001233333
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1708	173/9376	1.14231565837744	KPNA2/ACTG1/ACTB/CYCS/PYCARD/DNAJC3/MAP2K2/XPO1/VDAC1/JAK1/FDPS/EIF2S1/BAK1/OAS3/MX1/PABPN1/RAE1/TRIM25/PIK3CB/BID/AKT1/NUP98/SOCS3/IRF7/IFNAR1/CDK4/APAF1/EP300/CCND3/ADAR/STAT2/PML/RAF1/EIF2AK2/TNFRSF1A/MAPK1	0.891660536933996
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1708	32/9376	1.37236533957845	BIRC5/CYCS/HTRA2/BAK1/BID/APAF1/XIAP/TNFRSF1A	0.995786749119283
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1708	37/9376	1.33527438445471	ASL/ASRGL1/ADSL/ASNS/RIMKLB/GPT2/CAD/GFPT1/GOT1	0.964360841935603
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1708	42/9376	1.30701460912234	CP/PCBP2/VDAC3/SLC3A2/ACSL4/NCOA4/VDAC2/SAT2/ATG7/SLC39A8	0.941105491998522
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1708	52/9376	1.2667987749955	NPC2/TSPO/VDAC1/LDLR/VDAC3/PLTP/SORT1/LIPG/VDAC2/LRP1/STARD3NL/VAPB	0.910485198227249
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/1708	23/9376	1.432033397821	ASL/GPT2/NOS2/ARG2/CAD/GOT1	0.979026147240598
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1708	23/9376	1.432033397821	LNPEP/THOP1/ANPEP/NLN/ATP6AP2/ENPEP	0.979026147240598
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/1708	23/9376	1.432033397821	FXYD2/CA2/ATP1A1/ATP1B3/MDH1/PCK2	0.979026147240598
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	22/1708	103/9376	1.17250630954276	COL1A1/FXYD2/ATP1A1/COL6A2/COL4A1/COL6A3/COL4A2/SLC1A5/COL27A1/COL3A1/COL6A1/COL18A1/COL21A1/COL1A2/SLC3A2/COL9A3/ATP1B3/SLC36A4/COL5A2/COL5A1/SLC7A8/DPP4	0.830810518065609
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1708	43/9376	1.2766189205381	ACAT2/ACAT1/HADH/GCDH/ACSL4/ALDH1B1/ALDH3A2/ALDH2/ADH5/ALDH9A1	0.858013253583693
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1708	19/9376	1.44459509429311	DHTKD1/GLDC/DLAT/LIAS/PDHB	0.915507004363587
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	28/1708	137/9376	1.12193370826852	TUBA1C/TUBA1B/BIRC5/ACTG1/ACTB/LMNB1/LMNB2/CYCS/MAP2K2/HTRA2/EIF2S1/CASP6/BAK1/CTSV/PIK3CB/GADD45A/CTSH/BID/ATM/AKT1/ENDOG/FOS/ERN1/APAF1/XIAP/RAF1/TNFRSF1A/MAPK1	0.678516012461897
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1708	15/9376	1.46385636221702	ST3GAL1/SLC33A1/ST8SIA1/ST6GALNAC6	0.848509177269215
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1708	15/9376	1.46385636221702	AK1/ACP1/AK2/AK5	0.848509177269215
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1708	65/9376	1.18234552332913	AKR1B1/AGPAT5/AGPAT4/LIPG/ALDH1B1/ALDH3A2/ALDH2/LCLAT1/ALDH9A1/DGKZ/DGKD/GLA/GPAM/AGPAT2	0.696213018510998
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/1708	122/9376	1.12488962260529	ACTG1/ACTB/FXYD2/ATP1A1/DIO2/SLC2A1/PFKP/MAP2K2/BMP4/ATP2A2/ATP1B3/ITGAV/HIF1A/MED30/HDAC1/FOXO1/PIK3CB/HDAC2/AKT1/MYC/PFKL/EP300/RAF1/MAPK1/HDAC3	0.65528471868182
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/1708	55/9376	1.19770065999574	GM2A/CERS4/KDSR/CERS5/SMPD2/SPTLC2/SMPD4/UGCG/SGPP1/SAMD8/GLA/SPTLC1	0.693979639817308
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	42/1708	212/9376	1.08753479740179	CALM3/CALM1/ACTG1/PGF/ACTB/CDC42/ID1/RALB/MAP2K2/RHOA/FGF7/INSR/PFN1/IGF1/FGFR1/MAPK13/GNAI3/TLN1/PRKD3/RAC3/ITGB1/FLT4/ENAH/FGFR3/SIPA1L2/RALA/PRKCZ/PIK3CB/CRKL/AKT1/TIAM1/BRAF/GNAQ/EFNA4/CRK/VAV2/EVL/CTNND1/RAF1/VASP/MAPK1/RAPGEF2	0.60840761391502
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	27/1708	133/9376	1.11440192988326	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/GNB2/SLC18A2/MAPK13/GNB1/KIF5B/PPP3CA/GNAI3/GNB5/PPP2R1A/PPP2R5C/GNG12/PPP2R1B/CREB1/CREB3L2/AKT1/FOS/GNG11/PPP2R5E/PPP2R3A/GNAQ/MAOA/PPP2R5A	0.627106372530143
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1708	76/9376	1.15567607543449	CALM3/CALM1/GRB2/MAP2K2/IGF1/PTEN/BAK1/E2F1/PIK3CB/E2F3/GADD45A/AKT1/CDK4/BRAF/RAF1/MAPK1	0.643095862873857
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/1708	250/9376	1.07593442622951	HLA-G/HLA-C/CAV1/HSPA8/CDC42/SNF8/CBLB/RHOA/MVB12A/ACTR2/SNX5/CHMP4A/LDLR/ARPC1A/HLA-E/ARPC4/KIF5B/VPS28/VPS29/ARF3/ACTR3/VPS25/FGFR3/DNM2/PRKCZ/RAB10/ZFYVE16/EPN1/AP2S1/SPG21/ITCH/IL2RB/STAM2/EPS15L1/EEA1/RAB4A/SMAP1/ASAP3/IQSEC1/PIP5K1C/WIPF1/PSD4/AP2A1/GRK5/CAV2/WIPF2/PML/CHMP7/ACAP2	0.574324055580477
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/1708	56/9376	1.1763131482101	HSPA8/CYCS/PYCARD/SAR1A/BNIP3/SAR1B/HSPD1/C3/APAF1/RAB1B/CLK1/HSF1	0.624538587618552
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/1708	82/9376	1.13805906208945	HLA-G/HSPA5/HLA-C/CALR/HSP90AB1/HSP90AA1/HSPA8/HSPA2/CANX/PDIA3/NFYB/HLA-E/TAP1/HSPA4/CREB1/PSME3/RFXANK	0.59259642896386
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/1708	51/9376	1.18400146944024	ACTG1/ACTB/PDIA4/KDELR2/KDELR1/SEC61B/SEC61A1/SEC61G/ATP6V0B/KDELR3/ATP6V1A	0.621828292952582
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1708	16/9376	1.37236533957845	ST3GAL1/ST8SIA1/GLA/NAGA	0.703525487080691
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1708	62/9376	1.15101609125935	HSPA8/CRYAB/INSR/CLPB/IGF1/RPS6KB2/HDAC1/FOXO1/PIK3CB/HDAC2/AKT1/FOXO3/EIF4EBP2	0.563040289097282
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1708	104/9376	1.10844892812106	PLA2G2A/AGPAT5/LYPLA1/PTDSS2/AGPAT4/LPCAT1/CHPT1/PLA2G10/ETNK1/CHKA/PEMT/LCLAT1/PLA2G12A/SAMD8/DGKZ/DGKD/LPGAT1/MBOAT7/GPAM/AGPAT2/CDS2	0.524860320589523
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	31/1708	157/9376	1.08390638285177	CALR/ODC1/SLC16A1/SLC2A1/TGFB1/BSG/MAP2K2/ATP11A/UQCRFS1/MAPK13/PPARG/ATP2A2/XKR8/ITGAV/HIF1A/ATP11B/ELMO1/CREB1/LRP1/ADAM9/ATP11C/CRKL/ADAM10/VPS16/ADAM17/PPARD/ARNT/ARG2/CRK/ITGB5/MAPK1	0.500370200401371
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1708	99/9376	1.10898209258865	EIF4EBP1/GRB2/MAP2K2/SLC44A2/SLC44A1/LYPLA1/RPS6KB2/CHPT1/HIF1A/RAC3/CHKA/PIK3CB/AKT1/DGKZ/DGKD/FOS/PIP5K1C/SP1/RAF1/MAPK1	0.514466950627085
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/1708	78/9376	1.12604335555155	CALM3/CALM1/C1R/PYCARD/C1S/ITGA5/RHOA/CFL1/MAPK13/GNAI3/ITGB1/NOS2/C3/IRAK1/FOS/MAPK1	0.527546816027335
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1708	73/9376	1.12797151198229	MAP2K2/FGF7/IGF1/FGFR1/PTEN/BAK1/E2F1/PIK3CB/E2F3/GADD45A/AKT1/CDK4/BRAF/RAF1/MAPK1	0.518026217395455
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1708	73/9376	1.12797151198229	GRB2/MAP2K2/KIF5B/ERBB2/BAK1/E2F1/PIK3CB/E2F3/GADD45A/AKT1/CDK4/FOXO3/BRAF/RAF1/MAPK1	0.518026217395455
Organismal Systems	Immune system	hsa04611	Platelet activation	25/1708	126/9376	1.08917884093528	ACTG1/PPP1CC/ACTB/COL1A1/PPP1CB/PPP1CA/RHOA/COL3A1/COL1A2/PPP1R12A/MAPK13/GNAI3/TLN1/ITGB1/ORAI1/FYN/PRKCZ/LYN/PIK3CB/ROCK1/AKT1/GNAQ/ARHGEF1/VASP/MAPK1	0.475625081959243
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	46/1708	238/9376	1.06098832975813	RPS9/RPL29/RPL28/RPL7A/RPL18A/RPS3A/RPL36/RPSA/RPS15/RPL19/RPL15/RPLP0/CFD/RPS5/RPS6/RPL8/RPL5/C1R/RPL22L1/ISG15/RPS18/RPL13A/RPL14/RPL6/RPS19/RPL4/C1S/RPL3/JAK1/MAPK13/RPL26L1/RSL24D1/OAS3/MX1/C3/PIK3CB/IRAK1/ADAM17/IFNAR1/FOS/TAB2/ADAR/STAT2/EIF2AK2/TNFRSF1A/MAPK1	0.449777950080289
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/1708	196/9376	1.06428332457105	HLA-G/CALM3/HLA-C/CALM1/CYCS/MAP2K2/GNB2/JAK1/HLA-E/MAPK13/GNB1/PPP3CA/HIF1A/GNB5/BAK1/E2F1/TCF7L2/C3/GNG12/CCR1/LYN/CREB1/PIK3CB/E2F3/BID/AKT1/IRF7/IFNAR1/CDK4/FOS/GNG11/MYC/EP300/STAT2/RAF1/EIF2AK2/TNFRSF1A/MAPK1	0.429233434798089
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1708	22/9376	1.24760485416223	ALDH1B1/ALDH3A2/ALDH2/ALDH9A1/MAOA	0.548732055691789
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/1708	155/9376	1.06247639193171	CCNE1/CYP11A1/HSD3B1/MAP2K2/LDLR/FZD3/GNAI3/WNT7A/E2F1/TCF7L2/ORAI1/FH/WDR5/NR4A1/CCNE2/DVL3/CREB1/CREB3L2/AXIN2/E2F3/APC/CDK4/BRAF/KMT2A/MEN1/GNAQ/ARNT/AXIN1/SP1/MAPK1	0.370153020844898
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1708	38/9376	1.15567607543449	FXYD2/ATP1A1/INSR/SFN/IGF1/ATP1B3/PIK3CB/MAPK1	0.45381124947856
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1708	75/9376	1.09789227166276	GPX3/CGA/HSPA5/HSP90B1/PDIA4/FXYD2/CANX/ATP1A1/ATP1B3/CREB1/CREB3L2/GPX7/GPX8/GNAQ/TTF2	0.401700835969382
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	21/1708	107/9376	1.07737092079056	LDHA/PKM/CALM3/CALM1/PYGL/SLC2A1/PFKP/PGAM1/PRMT1/PPP3CA/GYS1/FOXO1/G6PC3/PCK2/CREB1/CREB3L2/AKT1/PFKL/EP300/PDHB/GNAQ	0.379875891639527
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/1708	86/9376	1.08512608245738	ACTG1/DSC2/ACTB/DSP/ITGA5/DSG2/ATP2A2/DAG1/SGCB/ITGAV/LAMA1/ITGB1/TCF7L2/PKP2/JUP/GJA1/ITGB5	0.374276479092486
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	34/1708	178/9376	1.04854879877904	CACYBP/DKK1/RHOA/APCDD1/CTBP2/PPP3CA/CSNK1E/FZD3/RUVBL1/WNT7A/RAC3/LGR4/TCF7L2/TLE3/DVL3/CSNK1A1/AXIN2/CTBP1/GPC4/APC/CCND2/SFRP1/PPARD/CUL1/MYC/CHD8/EP300/CCND3/BAMBI/PRICKLE3/AXIN1/NLK/FRAT2/CSNK2A1	0.308624434117311
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	41/1708	216/9376	1.04198109116142	CALM3/HSPA5/CALM1/HSP90B1/HSP90AB1/HSP90AA1/HSPA8/HSPA2/CYCS/PYCARD/CDC42/XBP1/CYBA/RHOA/LDLR/EIF2S1/MAPK13/PPARG/PPP3CA/HSPD1/CASP6/CCL3L1/HSPA4/LYN/POU2F1/PIK3CB/BID/CYP2J2/AKT1/IRAK1/IRF7/FOS/ATF6/TANK/ERN1/APAF1/ARHGEF1/TAB2/VAV2/TNFRSF1A/MAPK1	0.294592292762678
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/1708	103/9376	1.06591482685705	LAMA4/COL1A1/SERPINB9/COL4A1/TGFB1/IL1R1/COL4A2/COL3A1/COL1A2/VCL/LAMB1/ACTN1/LAMA1/LAMC1/NOS2/ACTN4/PIK3CB/LAMA5/GNAQ/ARG2	0.3174534983356
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	19/1708	98/9376	1.06428332457105	CALM3/CALM1/IMPA2/PTEN/PIK3C2G/INPP4B/PPIP5K2/PIK3CB/MTMR4/PIP4K2A/DGKZ/DGKD/PIP5K1C/IP6K2/CDS2/IPPK/MTMR2/PI4KA/INPP5A	0.301906666072771
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	23/1708	120/9376	1.05214676034348	CALM3/CALM1/GRB2/CDC42/MAP2K2/RHOA/SH2B2/MAPK13/SORT1/YWHAE/ARHGDIA/PIK3CB/CRKL/AKT1/IRAK1/KIDINS220/RIPK2/FOXO3/BRAF/ABL1/CRK/RAF1/MAPK1	0.271328117748637
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	30/1708	158/9376	1.04230278955326	RPS6/EIF4EBP1/GRB2/EIF4B/MAP2K2/RHOA/INSR/IGF1/RPS6KB2/PTEN/EIF4E/SLC3A2/DDIT4/FZD3/WNT7A/SEH1L/SLC7A5/ATP6V1A/CAB39L/CLIP1/DVL3/PIK3CB/SEC13/SLC38A9/AKT1/BRAF/RAF1/RICTOR/TNFRSF1A/MAPK1	0.253085764435577
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/1708	45/9376	1.09789227166276	ABCG2/ABCA7/TAP1/ABCB10/ABCD3/ABCC5/ABCB8/DEFB1/ABCD4	0.310655529480495
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1708	29/9376	1.13575062585803	TEAD4/WWTR1/CSNK1E/MOB1A/MOB1B/NF2	0.345535949030878
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1708	78/9376	1.05566564582958	IMPA2/TPI1/PTEN/PIK3C2G/INPP4B/PPIP5K2/PIK3CB/MTMR4/PIP4K2A/PIP5K1C/IP6K2/IPPK/MTMR2/PI4KA/INPP5A	0.232985182685726
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1708	35/9376	1.09789227166276	AKR1B1/TPI1/PFKP/ENOSF1/HK1/HK2/PFKL	0.273825735055034
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	28/1708	150/9376	1.02469945355191	CCNE1/GRB2/TGFB1/MAP2K2/FGF7/RPS6KB2/FZD3/WNT7A/ERBB2/BAK1/E2F1/TCF7L2/CCNE2/DVL3/CSNK1A1/AXIN2/PIK3CB/E2F3/GADD45A/AKT1/APC/JUP/BRAF/MYC/AXIN1/RAF1/FRAT2/MAPK1	0.143917885232407
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	21/1708	112/9376	1.02927400468384	HSPA8/LAMA4/PPIF/CYCS/TGFB1/JAK1/LDLR/MAPK13/LAMB1/GNAI3/LAMA1/ITGB1/LAMC1/NOS2/AKT1/IRAK1/LAMA5/XIAP/TAB2/TNFRSF1A/MAPK1	0.147089067743956
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1708	69/9376	1.03424634287072	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/SLC18A2/PPP3CA/HDAC1/CREB1/CREB3L2/HDAC2/FOS/MAOA	0.134748024907905
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	6/1708	31/9376	1.06247639193171	ALDH1B1/GUSB/ALDH3A2/ALDH2/UGDH/ALDH9A1	0.164435526811184
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1708	48/9376	1.02927400468384	FXYD2/ATP1A1/ATP1B3/SLC37A4/G6PC3/HK1/HK2/PIK3CB/AKT1	0.0959614954292498
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1708	26/9376	1.05566564582958	SLC5A6/SLC19A1/SLC19A2/LMBRD1/ABCD4	0.13413948663356
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1708	154/9376	0.998083883329785	CALM3/CALM1/TPM2/MYL4/TPM1/PPP1CC/FXYD2/ATP1A1/TPM4/PPP1CB/PPP1CA/TPM3/MAPK13/ATP2A2/GNAI3/ATP1B3/PPP2R1A/ATP2B4/PPP2R5C/PPP2R1B/CREB1/CREB3L2/AKT1/PPP2R5E/PPP2R3A/GNAQ/PPP2R5A/MAPK1	-0.0113150967045152
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/1708	71/9376	1.00511264307154	CGA/GRB2/MAP2K2/MAPK13/ELF5/PIK3CB/AKT1/CCND2/SOCS3/FOXO3/FOS/RAF1/MAPK1	0.0204082130460444
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1708	99/9376	0.998083883329785	MMP2/GRB2/MAP2K2/IGF1/MAPK13/RPS6KB2/ERBB2/E2F1/PIK3CB/CARM1/E2F3/AKT1/CDK4/BRAF/FOS/SP1/RAF1/MAPK1	-0.00904532732815169
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1708	21/9376	1.04561168729787	ALDH1B1/ALDH3A2/ALDH2/PANK3	0.0987534800419381
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/1708	166/9376	0.99207132981575	CALM3/CALM1/PPP1CC/FXYD2/PPIF/ATP1A1/PPP1CB/PPP1CA/MAP2K2/RHOA/INSR/VDAC1/VDAC3/PPP1R12A/ATP2A2/PPP3CA/GNAI3/ATP1B3/ATP2B4/CREB1/VDAC2/CREB3L2/ROCK1/AKT1/EDNRB/GNAQ/RAF1/SRF/VASP/MAPK1	-0.0486421878616734
NA	NA	hsa04519	Cadherin signaling	73/1708	404/9376	0.991907621675516	KRT19/ACTG1/PPP1CC/DSC2/ACTB/TEAD4/MYO1B/CDC42/PPP1CB/LIMA1/YWHAB/YWHAQ/PPP1CA/DSP/WWTR1/MAP2K2/RHOA/ACTR2/DSG2/KRT10/ARPC1A/VCL/FGFR1/MAPK13/ARPC4/NCKAP1/FZD3/CDH5/ACTN1/WNT7A/RAC3/YWHAH/ERBB2/TCF7L2/FLT4/APH1B/ACTR3/ENAH/MOB1A/MYO1E/BRK1/PKP2/TMC6/YWHAE/MYO7A/DSC3/PTK2B/DVL3/CSNK1A1/MOB1B/AXIN2/ACTN4/CIB2/ROCK1/ADAM10/APC/JUP/PKP3/TAOK1/ABI2/EP300/FAT2/PRICKLE3/MPDZ/AXIN1/GJA1/VAV2/NF2/EVL/CTNND1/RAF1/VASP/MAPK1	-0.0784712819471316
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/1708	155/9376	0.991644632469593	HLA-G/TUBA1C/TUBA1B/TUBB/HLA-C/ACTG1/CALR/TUBB4B/ACTB/TUBB6/C1R/CANX/CYBA/ITGA5/SEC61B/SEC61A1/SEC61G/ATP6V0B/HLA-E/ITGAV/TAP1/ITGB1/ATP6V1A/DYNC1LI1/C3/EEA1/DYNC1H1/ITGB5	-0.049502931203683
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	22/1708	122/9376	0.989902867892656	GRB2/CDC42/CBLB/MAP2K2/RHOA/MAP3K8/MAPK13/PPP3CA/PPP2R1A/FYN/PPP2R5C/PPP2R1B/PIK3CB/AKT1/CDK4/FOS/PPP2R5E/PPP2R3A/VAV2/PPP2R5A/RAF1/MAPK1	-0.0529787522328064
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1708	44/9376	0.998083883329785	DYNLL1/DYNC1LI1/ARHGDIA/CREB1/CREB3L2/NSF/DCTN2/DYNC1H1	-0.00601242181250799
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1708	50/9376	0.988103044496487	HBA2/HBA1/GYPC/GYPA/GYPB/CD81/HBB/TGFB1/LRP1	-0.0398072020473992
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	36/1708	201/9376	0.983187108951728	CCNA2/ETV5/FUS/DDX5/LMO2/IGF1/EWSR1/ETV4/PPARG/DUSP6/ID2/BAK1/HDAC1/FOXO1/MYCN/IGFBP3/REL/CCNT1/NFKBIZ/IL2RB/HDAC2/GADD45A/ATM/CCND2/JUP/KDM6A/TCF3/CCNT2/MYC/KMT2A/AFF1/MEN1/SS18/PML/BMP2K/SP1	-0.11371713517506
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/1708	67/9376	0.983187108951728	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/MAP2K2/PPP3CA/BRAF/EP300/GNAQ/RAF1/MAPK1	-0.065180367401593
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1708	16/9376	1.02927400468384	MIF/MAOA/GOT1	0.0553086074748972
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	34/1708	193/9376	0.967055368822123	CXCL14/CCR7/GRB2/CDC42/CCL21/RHOA/GNB2/GNB1/GNAI3/GNB5/RAC3/CCL3L1/ELMO1/PXN/PRKCZ/PTK2B/GNG12/CCR1/LYN/PIK3CB/ROCK1/CRKL/AKT1/TIAM1/FOXO3/BRAF/GNG11/GNAQ/GRK5/CRK/VAV2/STAT2/RAF1/MAPK1	-0.218252652987486
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1708	46/9376	0.954688931880664	ALAS2/CP/UROS/BLVRB/HMBS/MMAB/GUSB/CPOX	-0.145388786999122
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1708	86/9376	0.957464190403573	EIF4EBP1/GRB2/CBLB/MAP2K2/RPS6KB2/ERBB2/PIK3CB/CRKL/AKT1/BRAF/MYC/ABL1/CRK/RAF1/MAPK1	-0.187018509386584
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1708	69/9376	0.954688931880664	GRB2/MAP2K2/MAPK13/RAC3/FYN/LYN/PIK3CB/GAB2/AKT1/VAV2/RAF1/MAPK1	-0.17828405674138
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1708	17/9376	0.968728474996556	SEPHS1/PAPSS1/TXNRD1	-0.0609042104014573
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1708	52/9376	0.950099081246622	CGA/CYP11A1/HSD3B1/INSR/IGF1/LDLR/ACOT4/CYP2J2/HSD17B7	-0.170293315266001
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	20/1708	115/9376	0.954688931880664	GCM1/RHOA/PDE4D/MMP14/FGFR1/PTH1R/GNAI3/EGR1/MMP15/CREB1/CREB3L2/BRAF/FOS/PDE4C/GNAQ/ARHGEF1/SP1/RAF1/OXSR1/MAPK1	-0.2307346387258
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1708	47/9376	0.934376401415118	PKM/INSR/PRKCZ/HK1/HK2/PIK3CB/SOCS3/MAPK1	-0.212853082387865
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1708	53/9376	0.932172683487252	FXYD2/ATP1A1/PTH1R/ATP1B3/DNM2/ATP2B4/AP2S1/AP2A1/GNAQ	-0.233697059094794
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	18/1708	105/9376	0.941050518568083	TOMM20/PHB2/TOMM40/BNIP3/EIF2S1/HIF1A/E2F1/PGAM5/SAMM50/HUWE1/FOXO3/ATG9A/BNIP3L/OPA1/MFN1/ARIH1/SP1/CSNK2A1	-0.286681631460566
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1708	134/9376	0.942220979412073	CALM3/CALM1/PLA2G2A/RAMP1/PPP1CC/PPP1CB/PPP1CA/MAP2K2/RHOA/PPP1R14A/CALD1/MYL6B/PPP1R12A/ACTA2/PLA2G10/ROCK1/MYH9/PLA2G12A/BRAF/GNAQ/ARHGEF1/RAF1/MAPK1	-0.317927512586434
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1708	18/9376	0.914910226385636	FASN/ACSL4/CBR4	-0.17053385892193
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	14/1708	83/9376	0.925933241161367	PXMP4/ACSL4/CRAT/MPV17L2/NOS2/MPV17/ABCD3/AGPS/FAR1/PEX13/PXMP2/PEX19/PEX1/ABCD4	-0.319869577887409
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1708	60/9376	0.914910226385636	CDC42/MAP2K2/MAPK13/PPP3CA/RAC3/PXN/PIK3CB/AKT1/RAF1/MAPK1	-0.312051857968152
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1708	60/9376	0.914910226385636	MAP2K2/IGF1/GNAI3/PPP2R1A/LYN/PPP2R1B/BRAF/GNAQ/RAF1/MAPK1	-0.312051857968152
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1708	101/9376	0.923968743478563	MMP2/COL1A1/CDC42/COL4A1/TGFB1/COL4A2/COL3A1/DIAPH1/COL1A2/MAPK13/EGR1/FOXO1/PRKCZ/PIK3CB/AKT1/CDK4/MAPK1	-0.362563779022771
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1708	37/9376	0.890182922969808	MIF/GSTZ1/ADH5/FAH/MAOA/GOT1	-0.315870504202052
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1708	37/9376	0.890182922969808	HBA2/HBA1/LAMA4/HBB/THOP1/GNAQ	-0.315870504202052
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1708	90/9376	0.914910226385636	EIF4EBP1/INSR/IGF1/PPARG/RPS6KB2/EIF4E/FOXO1/CREB1/ADIPOR2/CREB3L2/PIK3CB/AKT1/RB1CC1/FOXO3/APPL1	-0.382800769858177
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	31/1708	183/9376	0.92990875468704	RAN/FBL/RRP7A/NOP56/GNL3/XPO1/DKC1/NOP58/IMP4/RBM28/POP5/WDR43/NOP10/TCOF1/MPHOSPH10/MDN1/RPP30/XRN2/GNL2/GAR1/GTPBP4/RPP40/NMD3/POP1/WDR75/POP7/EMG1/UTP6/UTP14C/PWP2/CSNK2A1	-0.451907147432645
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1708	32/9376	0.857728337236534	LDHA/PCCA/SUCLG2/PCCB/ACSS2	-0.380465691880481
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1708	32/9376	0.857728337236534	ATG12/ATG10/ATG9A/ATG2A/ATG7	-0.380465691880481
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1708	63/9376	0.871343072748225	BMP4/FZD3/WNT7A/BAK1/TCF7L2/DVL3/AXIN2/GADD45A/APC/AXIN1	-0.483556435261656
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1708	51/9376	0.861091977774716	PLA2G2A/PAFAH1B3/LPCAT1/CHPT1/PLA2G10/PAFAH1B1/AGPS/PLA2G12A	-0.469436133312094
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1708	93/9376	0.885396993276422	CGA/CALM3/CALM1/MMP2/GRB2/CDC42/MAP2K2/MMP14/MAPK13/EGR1/MAP3K4/PTK2B/GNAQ/RAF1/MAPK1	-0.524181670155189
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1708	99/9376	0.88718567407092	ACTG1/TPM2/TPM1/ACTB/TPM4/TGFB1/ITGA5/TPM3/IGF1/ATP2A2/DAG1/SGCB/ITGAV/LAMA1/ITGB1/ITGB5	-0.532557605283389
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1708	33/9376	0.831736569441488	STX2/VTI1B/STX16/YKT6/VTI1A	-0.456974592103076
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	31/1708	187/9376	0.910017658330098	HSP90AB1/HSP90AA1/PYCARD/SUGT1/CYBA/TRIP6/RHOA/VDAC1/JAK1/VDAC3/TXN2/ATG12/MAPK13/TXNIP/OAS3/YWHAE/GSDMD/VDAC2/DHX33/PKN2/PKN1/IRF7/IFNAR1/RIPK2/TANK/MFN1/XIAP/TAB2/TRPM7/STAT2/MAPK1	-0.586587072684699
NA	NA	hsa04517	IgSF CAM signaling	50/1708	299/9376	0.917970126808331	TUBA1C/TUBA1B/TUBB/DYNLL1/ACTG1/TUBB4B/ACTB/TUBB6/JAM3/IQGAP1/GRB2/CDC42/SPTBN1/ITGA5/MAP2K2/CLMP/RHOA/ACTR2/MYL6B/ARPC1A/VCL/FGFR1/MAPK13/ARPC4/ROBO1/PTPRS/ACTN1/ITGB1/ACTR3/FOXO1/FYN/PXN/SRGAP2/LYN/RDX/TRIO/ERC1/ACTN4/PIK3CB/AKT1/MYH9/ANK3/CNTNAP2/ABL1/MPDZ/F11R/VAV2/MSN/MAPK1/RAPGEF2	-0.680338402473066
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	30/1708	184/9376	0.895020873638122	CDC42/RHOA/CFL1/ROBO1/FES/PPP3CA/FZD3/GNAI3/RAC3/SEMA4B/ITGB1/FYN/ENAH/SRGAP2/PRKCZ/EPHB3/MYL5/SEMA7A/PIK3CB/ROCK1/BMPR2/RGS3/RHOD/EPHB4/SEMA4C/ABL1/EFNA4/SEMA6A/RAF1/MAPK1	-0.678727392669358
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/1708	90/9376	0.85391621129326	MAP2K2/JAK1/MAPK13/RPS6KB2/PTEN/PPP3CA/HIF1A/PIK3CB/AKT1/FOS/CD274/RAF1/MAPK1/CSNK2A1	-0.657199853817678
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1708	78/9376	0.844532516663664	CYBA/TGFB1/MARCKSL1/JAK1/MAPK13/ITGB1/NOS2/C3/IRAK1/FOS/TAB2/MAPK1	-0.6506997173391
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	11/1708	72/9376	0.838667707520167	ISG15/ATG12/MAPK13/PIN1/SIKE1/DDX3X/TRIM25/IRF7/TANK/AZI2/ADAR	-0.648546651927197
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/1708	103/9376	0.852731861485641	CALR/TGFB1/MAPK13/GNAI3/PPP2R1A/CCL3L1/NOS2/C3/PPP2R1B/PIK3CB/AKT1/IRAK1/FOS/GNAQ/TNFRSF1A/MAPK1	-0.709260541124416
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/1708	139/9376	0.868835610668374	KRT19/CALM3/CALM1/HSP90B1/MMP2/HSP90AB1/HSP90AA1/HSPA8/GRB2/MAP2K2/KRT10/GNAI3/FKBP4/CREB1/CREB3L2/PIK3CB/AKT1/FOS/GNAQ/SP1/RAF1/MAPK1	-0.735269225742356
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1708	43/9376	0.765971352322858	ACAT2/PLA2G2A/ACAT1/PLA2G10/PLA2G12A/AGPAT2	-0.725907255493036
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1708	105/9376	0.836489349838296	ACTG1/TPM2/TPM1/ACTB/TPM4/TGFB1/ITGA5/TPM3/IGF1/ATP2A2/DAG1/SGCB/ITGAV/LAMA1/ITGB1/ITGB5	-0.795180870313058
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1708	30/9376	0.731928181108509	PLA2G2A/PLA2G10/CYP2J2/PLA2G12A	-0.694044663636184
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1708	63/9376	0.784208765473402	PTGDS/PLA2G2A/PTGES3/PLA2G10/CBR1/PTGES2/PTGR1/CYP2J2/PLA2G12A	-0.811050305314624
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1708	76/9376	0.79452730186121	SCD/PLIN2/HMGCS1/FABP7/PLTP/PPARG/ACSL4/PCK2/SLC27A5/SLC27A6/PPARD	-0.848805070000569
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1708	31/9376	0.708317594621138	ALDH1B1/ALDH3A2/ALDH2/ALDH9A1	-0.767697181400219
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1708	17/9376	0.645818983331037	DAG1/MYH9	-0.689800550405933
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/1708	101/9376	0.815266538363438	CALM3/CALM1/MAP2K2/FZD3/GNAI3/WNT7A/TCF7L2/DVL3/CREB1/CREB3L2/EDNRB/EP300/GNAQ/RAF1/MAPK1	-0.880922728720468
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1708	70/9376	0.784208765473402	LEP/SLC2A1/ACSL4/G6PC3/PCK2/ADIPOR2/AKT1/SOCS3/APPL1/TNFRSF1A	-0.855243564241825
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1708	38/9376	0.722297547146555	ADA/TAP1/ORAI1/RFXANK/DCLRE1C	-0.809530281136338
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1708	89/9376	0.801831434360445	TUBA1C/TUBA1B/TUBB/CDK1/TUBB4B/TUBB6/GRB2/MAP2K2/GNAI3/GNAQ/GJA1/RAF1/MAPK1	-0.886503726940111
NA	NA	hsa04382	Cornified envelope formation	34/1708	217/9376	0.860099936325667	KRT19/CLDN10/CLDN6/S100A13/CLDN7/CLDN3/S100A1/COL4A1/DSP/COL4A2/PADI1/DSG2/KRT10/KAZN/ELOVL1/S100A16/CLDN4/PPP2R1A/KDSR/ABHD5/PKP2/FURIN/PPP2R5C/SPTLC2/PPP2R1B/UGCG/PLEC/JUP/PKP3/LAMA5/PPP2R5E/PPP2R3A/PPP2R5A/SPTLC1	-0.984038904527995
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1708	65/9376	0.760079264997298	CYP11A1/HSD3B1/LDLR/ORAI1/NR4A1/CREB1/CREB3L2/GNAQ/SP1	-0.916040800289417
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	48/1708	300/9376	0.878313817330211	STMN1/PGF/HSPA8/GRB2/CDC42/TGFB1/IL1R1/MAP2K2/FGF7/INSR/MAP3K8/IGF1/ECSIT/FLNA/FGFR1/MAPK13/DUSP6/MKNK1/PPP3CA/MAP4K4/RAC3/ERBB2/FLT4/FGFR3/NR4A1/MAP3K4/CDC25B/GNG12/GADD45A/CRKL/AKT1/IRAK1/PPP5C/TAOK1/BRAF/FOS/NF1/MYC/MKNK2/TAB2/EFNA4/CRK/RAF1/SRF/NLK/TNFRSF1A/MAPK1/RAPGEF2	-1.01098141134303
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/1708	140/9376	0.823419203747073	CALM3/CALM1/MYL4/RPS6/MAP2K2/GNB2/TFAM/GNB1/RPS6KB2/GNAI3/GNB5/ACTA2/EGR1/NOS2/GNG12/AKT1/GNG11/GNAQ/HDAC5/RAF1/MAPK1	-0.99346837278243
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/1708	91/9376	0.784208765473402	GRB2/CD81/MAP2K2/IFITM1/PPP3CA/RAC3/LYN/PIK3CB/AKT1/FOS/VAV2/RAF1/MAPK1	-0.976229800830985
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1708	122/9376	0.809920528275809	GRB2/MAP2K2/IGF1/MAPK13/GNAI3/IGFBP3/CREB1/CREB3L2/PIK3CB/CRKL/AKT1/SOCS3/FOS/EP300/GNAQ/CRK/RAF1/MAPK1	-0.997330046785642
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/1708	98/9376	0.784208765473402	CALM3/CALM1/CYP11A1/ATP1A1/HSD3B1/LDLR/ATP1B3/PRKD3/ORAI1/NR4A1/ATP2B4/CREB1/CREB3L2/GNAQ	-1.01346364112904
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1708	26/9376	0.633399387497748	PLA2G2A/PLA2G10/PLA2G12A	-0.883410534949176
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	21/1708	142/9376	0.81182175017317	GRB2/CYBA/TGFB1/IL1R1/JAK1/MAPK13/PPARG/ATP2A2/PPP3CA/FYN/CREB1/PIK3CB/GAB2/AKT1/SOCS3/IFNAR1/FOS/TAB2/STAT2/TNFRSF1A/MAPK1	-1.0663681896791
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	22/1708	149/9376	0.810524495858416	NDUFA4/NDUFV3/NDUFC1/NDUFA6/NDUFB11/GNB2/NDUFV2/NDUFS6/NDUFS7/NDUFA3/MAPK13/GNB1/NDUFA12/NDUFS2/GNAI3/GNB5/NDUFA9/GNG12/NDUFS3/GNG11/GNAQ/MAPK1	-1.10028315590218
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1708	94/9376	0.759180826149783	HSP90B1/HSP90AB1/HSP90AA1/SRSF1/MAPK13/ANAPC5/ELAVL1/MAPK6/TRAF4/IL17D/FOS/TAB2/MAPK1	-1.10744642677458
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	27/1708	181/9376	0.818869926378304	CALM3/CALM1/CYCS/TGFB1/RHOA/NFYB/JAK1/ATP6V0B/MAPK13/PPP3CA/HSPD1/HSPA9/NOS2/C3/CREB1/BID/AKT1/CEBPG/EEA1/IRAK1/RIPK2/APAF1/EP300/RFXANK/RAF1/TNFRSF1A/MAPK1	-1.16129485932566
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/1708	169/9376	0.812050496791985	HMGB1/BNIP3/MAP2K2/ATG12/EIF2S1/RPS6KB2/PTEN/DDIT4/HIF1A/VMP1/WDR45B/PIK3CB/MTMR4/AKT1/VPS16/RB1CC1/ATG10/TANK/ERN1/ATG9A/YKT6/ATG2A/ATG7/RAF1/MAPK1	-1.16362751539332
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1708	76/9376	0.722297547146555	CALM3/CALM1/ACTG1/GAST/ACTB/CA2/ATP1A1/GNAI3/ATP1B3/GNAQ	-1.14718525657545
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1708	83/9376	0.727518975198217	POLR2H/PYCARD/G3BP1/POLR1D/POLR2L/GSDMD/IRF7/POLR3H/DNASE2/ADAR/POLR3D	-1.17675448139379
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	36/1708	238/9376	0.830338692854191	CALM3/CALM1/PGF/PLA2G2A/RALBP1/GRB2/CDC42/RALB/MAP2K2/RHOA/FGF7/INSR/GNB2/IGF1/FGFR1/GNB1/GNB5/RAC3/PLA2G10/FLT4/FGFR3/RALA/REL/GNG12/PIK3CB/GAB2/AKT1/PLA2G12A/TIAM1/NF1/GNG11/ABL1/EFNA4/RAF1/RALGAPB/MAPK1	-1.25122159007492
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1708	36/9376	0.609940150923758	AKR1B1/DCXR/GUSB/UGDH	-1.10661761741506
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1708	36/9376	0.609940150923758	GALNT1/GALNT2/ST3GAL1/GALNT6	-1.10661761741506
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	50/1708	323/9376	0.849761820172418	CCNE1/STMN1/TPM1/IGF2BP1/GRB2/EZH2/CDCA5/ITGA5/MAP2K2/RHOA/SLC7A1/KIF23/TRIM71/HNRNPK/PTEN/DDIT4/CDC25A/FZD3/DNMT3B/ERBB2/BAK1/CDC25C/E2F1/SOX4/HDAC1/FGFR3/CCNE2/CDC25B/FSCN1/BRCA1/RDX/MDM4/PIK3CB/HDAC2/ROCK1/E2F3/BMPR2/CRKL/ATM/APC/CCND2/MYC/EP300/ABL1/EFNA4/CRK/HDAC5/CCNG1/RAF1/MAPK1	-1.29680248369971
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1708	29/9376	0.567875312929016	CALM3/CALM1/GNB1	-1.0999184195504
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1708	71/9376	0.695847214434146	JAM3/CDC42/ATP6V0B/MAPK13/ATP6V1A/LYN/ADAM10/ADAM17/F11R	-1.21409117740373
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1708	44/9376	0.623802427081116	GTF2F2/TBPL1/TAF4B/TAF12/GTF2H3	-1.18043881585571
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1708	65/9376	0.675626013330931	CGA/MAP2K2/KISS1R/PIK3CB/AKT1/GNAQ/RAF1/MAPK1	-1.2384915640495
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	32/1708	217/9376	0.809505822424157	KPNA2/BIRC5/MGST1/HSP90B1/HSP90AB1/EIF4EBP1/HSP90AA1/KPNB1/GRB2/GSTO1/MGST3/MAP2K2/FGF7/PTGES3/CDC6/RPS6KB2/GSTA4/CDC25A/GNAI3/E2F1/KPNA4/CREB1/CREB3L2/PIK3CB/AKT1/FOS/MYC/CCND3/ARNT/XIAP/RAF1/MAPK1	-1.33991134026257
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/1708	144/9376	0.762425188654697	SCD/TRA2A/TRA2B/MAPK13/FASN/ALDH1B1/TCF7L2/FOXO1/ALDH3A2/C3/ADIPOR2/ALDH2/ADH5/AKT1/IRAK1/ALDH9A1/FOXO3/SREBF1/TAB2/TNFRSF1A	-1.35588314012404
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/1708	119/9376	0.738078838092614	MAP3K8/MMP14/MAPK13/PGAM5/CREB1/ITCH/CREB3L2/PIK3CB/AKT1/SOCS3/ADAM17/FOS/XIAP/TAB2/TNFRSF1A/MAPK1	-1.35705502261641
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/1708	109/9376	0.705068431343059	MAP2K2/MAP3K8/JAK1/MAPK13/CCL3L1/PIK3CB/AKT1/IRAK1/IRF7/IFNAR1/FOS/TAB2/STAT2/MAPK1	-1.46168384642276
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/1708	149/9376	0.736840450780378	GRB2/AGPAT5/RALB/MAP2K2/RHOA/INSR/AGPAT4/FYN/DNM2/RALA/PTK2B/PIK3CB/GAB2/AKT1/DGKZ/DGKD/PIP5K1C/AGPAT2/RAF1/MAPK1	-1.52816597920118
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/1708	97/9376	0.67910862164707	CALM3/CALM1/GNB2/GNB1/GNAI3/GNB5/GNG12/CREB1/FOS/GNG11/GNAQ/MAPK1	-1.49927689335103
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1708	56/9376	0.588156574105052	CSNK1E/CSNK1G2/CSNK1A1/CCND2/EVC2/CUL1	-1.45883681472189
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	32/1708	226/9376	0.777268864893992	CGA/CALM3/CALM1/PPP1CC/FXYD2/ATP1A1/PPP1CB/PPP1CA/MAP2K2/RHOA/PDE4D/PPP1R12A/ATP2A2/GNAI3/ATP1B3/RAC3/ORAI1/ATP2B4/CREB1/CREB3L2/PIK3CB/ROCK1/AKT1/TIAM1/HCAR3/BRAF/FOS/PDE4C/EP300/VAV2/RAF1/MAPK1	-1.59960635989718
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1708	49/9376	0.560149118195288	SLC18A2/GNAI3/CREB1/CREB3L2/MAOA	-1.45687079676784
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1708	105/9376	0.679647596743616	CALM3/CALM1/PYCARD/CBLB/RHOA/MAPK13/PPP3CA/PIK3CB/IL17D/AKT1/STAT2/RAF1/MAPK1	-1.5579297285918
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1708	34/9376	0.484364237498278	CSNK1E/CREB1/CUL1	-1.42151378975198
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1708	79/9376	0.625381673731954	SLC18A2/ATP6V0B/STX2/SLC1A2/DNM2/ATP6V1A/AP2S1/NSF/AP2A1	-1.57804603591124
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1708	17/9376	0.322909491665519	SLC27A5	-1.31869689041041
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1708	17/9376	0.322909491665519	CA2	-1.31869689041041
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/1708	154/9376	0.712917059521275	CALM3/CALM1/ACTG1/PPP1CC/ACTB/PPP1CB/EEF2/PPP1CA/MAP2K2/RHOA/MYL6B/PPP1R12A/PPP3CA/GNAI3/ROCK1/FOS/GNAQ/EEF2K/RAF1/MAPK1	-1.6952888538717
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1708	59/9376	0.558250307625134	CGA/INSR/GNAI3/ABHD5/PIK3CB/AKT1	-1.60639644032154
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	14/1708	115/9376	0.668282252316465	GNB2/GNB1/GNAI3/GNB5/FYN/GNG12/CREB1/CREB3L2/PIK3CB/AKT1/FOS/GNG11/GNAQ/MAPK1	-1.68918495739531
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1708	44/9376	0.499041941664892	HLA-G/HLA-C/HLA-E/HSPD1	-1.57191428053678
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1708	102/9376	0.645818983331037	PLA2G2A/FXYD2/CA2/ATP1A1/RHOA/ATP2A2/ATP1B3/PLA2G10/ATP2B4/RAB3D/PLA2G12A/GNAQ	-1.69738492054333
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1708	28/9376	0.392104382736701	CA2/ATP6V1A	-1.52032765462498
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1708	191/9376	0.718515884596049	CALM3/CALM1/PPP1CC/GRB2/PPP1CB/PPP1CA/GNB2/SLC18A2/GNB1/GNAI3/GNB5/HDAC1/GNG12/CREB1/CREB3L2/HAT1/HDAC2/SLC29A2/BRAF/GNG11/MAOA/HDAC5/RAF1/MAPK1/HDAC3	-1.85489578578202
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1708	69/9376	0.556901876930387	CALM3/CALM1/PPP3CA/GNAI3/ORAI1/CREB1/GNAQ	-1.74344446498781
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1708	19/9376	0.288919018858622	GUSB	-1.46425281623885
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1708	38/9376	0.433378528287933	NT5C/NNMT/NT5M	-1.65175796821294
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/1708	105/9376	0.627367012378722	IL1R1/CCL21/LYN/ERC1/TRIM25/GADD45A/ATM/IRAK1/XIAP/TAB2/TNFRSF1A/CSNK2A1	-1.81217934801804
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/1708	133/9376	0.660386328819707	HLA-G/HLA-C/GRB2/MAP2K2/HLA-E/PPP3CA/RAC3/FYN/PTK2B/PIK3CB/BID/IFNAR1/BRAF/VAV2/RAF1/MAPK1	-1.86162853732321
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1708	99/9376	0.609940150923758	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/IL1R1/IGF1/MAPK13/PIK3CB/CYP2J2/GNAQ	-1.84133830017148
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1708	39/9376	0.422266258331832	HLA-G/HLA-C/HLA-E	-1.70625868890491
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/1708	168/9376	0.686182669789227	HMGB1/PPIA/PYGL/HSP90AB1/HSP90AA1/PYCARD/VDAC1/JAK1/CHMP4A/VDAC3/PGAM5/VDAC2/PPID/BID/IFNAR1/XIAP/TRPM7/STAT2/CHMP7/EIF2AK2/TNFRSF1A	-1.93703482236053
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1708	79/9376	0.55589482109507	MGST1/GSTO1/MGST3/GSTP1/GSTA4/CBR1/ADH5/CYP2S1	-1.87075315850173
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1708	115/9376	0.620547805722432	GNB2/SLC18A2/GNB1/GNAI3/GNB5/GNG12/CYP2J2/BRAF/GNG11/GNAQ/MAOA/RAF1/MAPK1	-1.93226001050689
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1708	73/9376	0.526386705591736	MGST1/GSTO1/MGST3/GSTP1/GSTA4/ADH5/MAOA	-1.91717749997721
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/1708	250/9376	0.724608899297424	CD63/LAPTM4B/NPC2/ATP6V0B/CD164/LITAF/SORT1/GM2A/VPS29/SLC36A4/BLOC1S1/GUSB/CTSV/ATP6V1A/CLN6/AP3D1/AP2S1/OSBPL1A/AP4M1/SLC38A9/CTSH/CLN5/SLC29A2/VPS16/AP5B1/DNASE2/OSTM1/GLA/AP2A1/PPT2/NAGA/AP3B1/KXD1	-2.08289891265172
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/1708	160/9376	0.651873536299766	HLA-G/HLA-C/CLDN10/CLDN6/JAM3/CLDN7/VCAN/CLDN3/SDC4/HLA-E/PTPRS/CDH5/ITGAV/ITGB1/CLDN4/CD276/CD274/CNTNAP2/F11R	-2.09611118823815
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1708	90/9376	0.548946135831382	ABCG2/FXYD2/CA2/ATP1A1/SLC2A1/HMGCR/LDLR/ATP1B3/SLC27A5	-2.02919527361518
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1708	68/9376	0.484364237498278	RDH11/PNPLA4/ADH5/CYP2S1/RETSAT/RDH13	-2.01399236133739
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/1708	91/9376	0.542913760712356	GNB2/PDE4D/GNB1/GNAI3/GNB5/GNG12/GNG11/PDE4C/GRK5	-2.06783750656638
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1708	70/9376	0.470525259284041	MGST1/GSTO1/MGST3/GSTP1/GSTA4/CBR1	-2.09846273607614
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1708	45/9376	0.365964090554254	HLA-G/HLA-C/HLA-E	-2.01207672283938
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1708	86/9376	0.510647568215239	FXYD2/ATP1A1/SLC2A1/TRPM4/ATP1B3/CREB1/CREB3L2/GNAQ	-2.15155096906333
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1708	54/9376	0.406626767282505	HLA-G/CGA/HLA-C/HLA-E	-2.06375814894436
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/1708	109/9376	0.553982338912404	HSP90AB1/HSP90AA1/TGFB1/IL1R1/JAK1/MAPK13/PPP3CA/HIF1A/IL2RB/FOS/MAPK1	-2.21046805331756
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/1708	88/9376	0.499041941664892	TFPI/CFD/C1R/PROCR/CD55/C1S/C3/SERPINB2	-2.22828183018301
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	23/1708	195/9376	0.647474929442143	HMGB1/ACTG1/ACTB/PPIF/CYBA/MAP2K2/VDAC1/VDAC3/MAPK13/CLCN3/HDAC1/GSDMD/C3/VDAC2/HAT1/PIK3CB/HDAC2/AKT1/HDAC5/ATG7/RAF1/MAPK1/HDAC3	-2.34774454127468
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1708	89/9376	0.493434728837197	GNB2/GNB1/SLC38A1/GNAI3/GNB5/GNG12/NSF/GNG11	-2.26611117345958
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1708	66/9376	0.415868284720744	CYP11A1/HSD3B1/HSD17B12/SRD5A3/HSD17B7	-2.24748309280063
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1708	116/9376	0.520552370184931	GNB2/GNB1/SLC38A1/PPP3CA/GNAI3/GNB5/SLC1A2/GNG12/GNG11/GNAQ/MAPK1	-2.45218480249662
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/1708	168/9376	0.555481208876993	LEP/GRB2/JAK1/LIFR/PIK3CB/IL2RB/PTPN2/STAM2/AKT1/CCND2/SOCS3/IFNAR1/MYC/EP300/CCND3/STAT2/RAF1	-2.74378848682625
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/1708	93/9376	0.413185263528997	JAK1/MAPK13/PPP3CA/IL2RB/FOS/MAML1/MAPK1	-2.68402668855776
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/1708	93/9376	0.413185263528997	CALM3/CALM1/FXYD2/ATP1A1/ATP1B3/ATP2B4/GNAQ	-2.68402668855776
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1708	99/9376	0.388143732406027	KRT19/CFD/C1R/C1S/KRT10/C3/DEFB1	-2.88836285608195
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/1708	100/9376	0.384262295081967	CXCL14/CCR7/CCL21/CCL3L1/CCR1/IL2RB/TNFRSF1A	-2.92148659464482
NA	NA	hsa04081	Hormone signaling	22/1708	219/9376	0.551452739191342	CGA/LEP/GAST/RAMP1/DIO2/RHOA/INSR/GNB2/IGF1/GNB1/PTH1R/GNAI3/ITGAV/GNB5/GNG12/ADIPOR2/PIK3CB/GNG11/GNAQ/SMAD5/APPL1/ACVR1	-3.16987530483227
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/1708	95/9376	0.288919018858622	TGFB1/ATP6V0B/CCL3L1/ATP6V1A/FOS	-3.28754721334721
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1708	50/9376	0.109789227166276	TGFB1	-2.9786444177672
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/1708	100/9376	0.274473067915691	GYPA/CD55/IL1R1/ITGA5/ANPEP	-3.44240281082065
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1708	143/9376	0.307102733332241	C1R/SNRPD1/C1S/SSB/SNRPB/ACTN1/C3/ACTN4	-3.94052392211788
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1708	66/9376	0.0831736569441487	TGFB1	-3.52754635838797
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	20/1708	254/9376	0.432241051835734	CALM3/CALM1/PPIF/FGF7/VDAC1/VDAC3/FGFR1/ATP2A2/PPP3CA/ERBB2/FLT4/ORAI1/FGFR3/ATP2B4/PTK2B/NOS2/VDAC2/MST1/EDNRB/GNAQ	-4.32936629024191
NA	NA	hsa04082	Neuroactive ligand signaling	9/1708	199/9376	0.248267096607158	GNB2/SLC18A2/GNB1/GNAI3/GNB5/SLC1A2/GNG12/GNG11/GNAQ	-5.0585756758122
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/1708	298/9376	0.34999921412068	CXCL14/LEP/CCR7/TGFB1/IL1R1/CCL21/LIFR/BMP4/ACVRL1/CCL3L1/CCR1/IL2RB/IL17D/BMPR2/ACVR2B/IFNAR1/IL36RN/ACVR1/TNFRSF1A	-5.38164992790697
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/1708	370/9376	0.222545730742452	CGA/LEP/TMEM97/GZMA/TSPO/GAL/NPW/RLN2/PGRMC1/PTH1R/VGF/KISS1R/C3/NMB/EDNRB	-7.20109039687124
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1708	449/9376	0.0489038873791877	CALM3/CALM1/GNB1/NCALD	-9.74727746877211