ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 57/623 175/18639 0.325714285714286 9.74476496216464 9.37942798145917e-41 7.39098924938982e-38 GO:0004601 peroxidase activity 19/623 57/18639 0.333333333333333 9.97271268057785 1.34490968723965e-14 5.29894416772421e-12 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 19/623 59/18639 0.322033898305085 9.63465462360911 2.77138008808671e-14 7.27949169804109e-12 GO:0016209 antioxidant activity 22/623 86/18639 0.255813953488372 7.65347717346672 5.37740547635318e-14 1.05934887884158e-11 GO:0045296 cadherin binding 41/623 334/18639 0.122754491017964 3.67258580751819 6.19466665397586e-13 9.76279464666596e-11 GO:0098632 cell-cell adhesion mediator activity 14/623 55/18639 0.254545454545455 7.61552604698672 2.30780785010031e-09 3.03092097646507e-07 GO:0019843 rRNA binding 15/623 65/18639 0.230769230769231 6.90418570193851 2.7089062443999e-09 3.0494544579816e-07 GO:0098631 cell adhesion mediator activity 16/623 76/18639 0.210526315789474 6.29855537720706 3.37181210117494e-09 3.32123491965731e-07 GO:0031720 haptoglobin binding 7/623 10/18639 0.7 20.9426966292135 4.9568779467828e-09 4.3400220245165e-07 GO:0098641 cadherin binding involved in cell-cell adhesion 8/623 18/18639 0.444444444444444 13.2969502407705 4.84726776042199e-08 3.81964699521252e-06 GO:0004857 enzyme inhibitor activity 37/623 416/18639 0.0889423076923077 2.6609882392888 6.78536262609076e-08 4.86078704487229e-06 GO:0019825 oxygen binding 10/623 34/18639 0.294117647058824 8.79945236521575 1.02828243560146e-07 6.75238799378291e-06 GO:0005344 oxygen carrier activity 7/623 14/18639 0.5 14.9590690208668 1.26089481697567e-07 7.64296242905253e-06 GO:1990948 ubiquitin ligase inhibitor activity 6/623 11/18639 0.545454545454545 16.3189843864001 5.45060038149013e-07 3.06790935758158e-05 GO:0048027 mRNA 5'-UTR binding 8/623 24/18639 0.333333333333333 9.97271268057785 6.81928738936109e-07 3.58239897521103e-05 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/623 15/18639 0.4 11.9672552166934 5.26472559932174e-06 0.00024403551601562 GO:0055105 ubiquitin-protein transferase inhibitor activity 6/623 15/18639 0.4 11.9672552166934 5.26472559932174e-06 0.00024403551601562 GO:0004602 glutathione peroxidase activity 7/623 23/18639 0.304347826086957 9.10552027357108 6.92465393948824e-06 0.00030314596135093 GO:0009055 electron transfer activity 15/623 116/18639 0.129310344827586 3.86872474677589 7.45033487483808e-06 0.000308992835861706 GO:0004364 glutathione transferase activity 7/623 27/18639 0.259259259259259 7.7565543071161 2.23249500620671e-05 0.000879603032445444 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/623 13/18639 0.384615384615385 11.5069761698975 4.22711584371305e-05 0.00158617489754566 GO:0031406 carboxylic acid binding 18/623 187/18639 0.0962566844919786 2.87982077407061 5.82291991821733e-05 0.00208566404343421 GO:0033293 monocarboxylic acid binding 11/623 79/18639 0.139240506329114 4.1658166893553 6.11294888863135e-05 0.00209434944532239 GO:0043177 organic acid binding 18/623 189/18639 0.0952380952380952 2.8493464801651 6.69069957500198e-05 0.00219677969379232 GO:0061134 peptidase regulator activity 20/623 226/18639 0.0884955752212389 2.64762283555164 7.58844858378743e-05 0.0023918789936098 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/623 68/18639 0.147058823529412 4.39972618260787 8.19976128655846e-05 0.00248515842069541 GO:0004129 cytochrome-c oxidase activity 5/623 15/18639 0.333333333333333 9.97271268057785 9.32914443397297e-05 0.00272272807924841 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/623 16/18639 0.3125 9.34941813804173 0.00013197586663061 0.00371417796089002 GO:0022853 active monoatomic ion transmembrane transporter activity 13/623 118/18639 0.110169491525424 3.29606605544522 0.000159991644859998 0.00424490092647335 GO:0055106 ubiquitin-protein transferase regulator activity 7/623 36/18639 0.194444444444444 5.81741573033708 0.000161607903292133 0.00424490092647335 GO:0051015 actin filament binding 18/623 209/18639 0.0861244019138756 2.57668174522107 0.00023957530831898 0.00608984977275342 GO:0004867 serine-type endopeptidase inhibitor activity 11/623 95/18639 0.115789473684211 3.46420545746388 0.000326347000971565 0.00803027419230276 GO:0004866 endopeptidase inhibitor activity 15/623 161/18639 0.093167701863354 2.7874041653789 0.000336293208560903 0.00803027419230276 GO:0051287 NAD binding 8/623 54/18639 0.148148148148148 4.43231674692349 0.000398786365750279 0.00924246047680058 GO:0030414 peptidase inhibitor activity 15/623 169/18639 0.0887573964497041 2.65545603920712 0.000563323961196082 0.0126828366120718 GO:0005504 fatty acid binding 7/623 47/18639 0.148936170212766 4.45589289983266 0.000886184693521988 0.0193975982915368 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 8/623 61/18639 0.131147540983607 3.92369023498145 0.000919911746772478 0.0195916339582895 GO:0020037 heme binding 13/623 142/18639 0.0915492957746479 2.73898446860941 0.000966672756876558 0.0200457403268086 GO:0003779 actin binding 28/623 443/18639 0.0632054176072235 1.89098840895833 0.0010081826136305 0.0203704589625855 GO:0061135 endopeptidase regulator activity 15/623 184/18639 0.0815217391304348 2.43897864470654 0.00134721246671459 0.0265400855942775 GO:0015399 primary active transmembrane transporter activity 14/623 166/18639 0.0843373493975904 2.52321646135102 0.00139480718214656 0.0266819313318046 GO:0015078 proton transmembrane transporter activity 15/623 185/18639 0.0810810810810811 2.42579497635677 0.0014221333958576 0.0266819313318046 GO:0017070 U6 snRNA binding 4/623 16/18639 0.25 7.47953451043339 0.00163227317055587 0.0299123548464657 GO:0046906 tetrapyrrole binding 13/623 152/18639 0.0855263157894737 2.55878812199037 0.00179876231933573 0.0320085356793671 GO:0016860 intramolecular oxidoreductase activity 7/623 53/18639 0.132075471698113 3.95145219419122 0.00182789861113137 0.0320085356793671 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/623 40/18639 0.15 4.48772070626003 0.00198384421962679 0.0339841140231719 GO:0019887 protein kinase regulator activity 18/623 255/18639 0.0705882352941176 2.11186856765178 0.00240363193059891 0.0402991906662115 GO:0043236 laminin binding 5/623 29/18639 0.172413793103448 5.15829966236785 0.0025051412301609 0.040388855355804 GO:0008307 structural constituent of muscle 6/623 42/18639 0.142857142857143 4.27401972024765 0.00256274462917538 0.040388855355804 GO:0042056 chemoattractant activity 6/623 42/18639 0.142857142857143 4.27401972024765 0.00256274462917538 0.040388855355804 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/623 122/18639 0.0901639344262295 2.69753703654975 0.0026151665225299 0.0404068866618345 GO:0016853 isomerase activity 14/623 180/18639 0.0777777777777778 2.32696629213483 0.00296658926325173 0.0449552372969686 GO:0008301 DNA binding, bending 4/623 19/18639 0.210526315789474 6.29855537720706 0.00321025203430528 0.0477297849628785 GO:0005522 profilin binding 3/623 10/18639 0.3 8.97544141252006 0.00374048825705178 0.0539480761085027 GO:0019207 kinase regulator activity 19/623 287/18639 0.0662020905923345 1.98064328499281 0.00376541140351224 0.0539480761085027 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/623 46/18639 0.130434782608696 3.90236583153046 0.00408943225721968 0.0575441539051626 GO:0005200 structural constituent of cytoskeleton 10/623 112/18639 0.0892857142857143 2.67126232515478 0.00431485022838382 0.059650911929236 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 11/623 132/18639 0.0833333333333333 2.49317817014446 0.00479053819606676 0.0648015224865601 GO:0003712 transcription coregulator activity 28/623 495/18639 0.0565656565656566 1.6923391215526 0.00490945106983601 0.0648015224865601 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/623 11/18639 0.272727272727273 8.15949219320006 0.00501636151228448 0.0648015224865601 GO:0045294 alpha-catenin binding 3/623 11/18639 0.272727272727273 8.15949219320006 0.00501636151228448 0.0648015224865601 GO:0090482 vitamin transmembrane transporter activity 5/623 34/18639 0.147058823529412 4.39972618260787 0.00511793401134778 0.0650472903377751 GO:0140517 protein-RNA adaptor activity 4/623 22/18639 0.181818181818182 5.43966146213337 0.00559668197947893 0.0700029428544349 GO:0004859 phospholipase inhibitor activity 3/623 12/18639 0.25 7.47953451043339 0.00652386026793626 0.0803250295489653 GO:0050840 extracellular matrix binding 7/623 67/18639 0.104477611940299 3.12577561630052 0.00691213559465848 0.0834295799808058 GO:0004860 protein kinase inhibitor activity 8/623 84/18639 0.0952380952380952 2.8493464801651 0.00698775669889998 0.0834295799808058 GO:0016829 lyase activity 14/623 200/18639 0.07 2.09426966292135 0.00748077251329403 0.0879828170220252 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/623 24/18639 0.166666666666667 4.98635634028892 0.00771255788043519 0.0893749354379842 GO:0005542 folic acid binding 3/623 13/18639 0.230769230769231 6.90418570193851 0.00827264622979947 0.0931263604154569 GO:0070700 BMP receptor binding 3/623 13/18639 0.230769230769231 6.90418570193851 0.00827264622979947 0.0931263604154569 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/623 54/18639 0.111111111111111 3.32423756019262 0.00901435726638386 0.100046669379021 GO:0140313 molecular sequestering activity 6/623 55/18639 0.109090909090909 3.26379687728002 0.00983992010094342 0.107692458882547 GO:0044548 S100 protein binding 3/623 14/18639 0.214285714285714 6.41102958037147 0.0102705978730597 0.109423409763211 GO:0015036 disulfide oxidoreductase activity 5/623 40/18639 0.125 3.73976725521669 0.0102758024396924 0.109423409763211 GO:0019210 kinase inhibitor activity 8/623 90/18639 0.0888888888888889 2.65939004815409 0.0104532226405829 0.109828525877057 GO:0005201 extracellular matrix structural constituent 12/623 168/18639 0.0714285714285714 2.13700986012382 0.0109587841860351 0.113625288665732 GO:0072341 modified amino acid binding 8/623 91/18639 0.0879120879120879 2.63016598169086 0.0111360424394469 0.1139636550946 GO:0022804 active transmembrane transporter activity 25/623 457/18639 0.0547045951859956 1.63665963029177 0.0112871590461801 0.114029247799871 GO:0019842 vitamin binding 11/623 150/18639 0.0733333333333333 2.19399678972713 0.0120927432353026 0.12044158078983 GO:0031386 protein tag activity 3/623 15/18639 0.2 5.98362760834671 0.012523947630181 0.12044158078983 GO:0141047 molecular tag activity 3/623 15/18639 0.2 5.98362760834671 0.012523947630181 0.12044158078983 GO:0003713 transcription coactivator activity 16/623 256/18639 0.0625 1.86988362760835 0.0125332609451346 0.12044158078983 GO:0008201 heparin binding 12/623 172/18639 0.0697674418604651 2.08731195640001 0.0130305354032817 0.123711589129952 GO:0005506 iron ion binding 11/623 154/18639 0.0714285714285714 2.13700986012382 0.0144999012871942 0.136022883503679 GO:0055102 lipase inhibitor activity 3/623 16/18639 0.1875 5.60965088282504 0.0150374109670176 0.139405645200116 GO:0016836 hydro-lyase activity 6/623 61/18639 0.0983606557377049 2.94276767623609 0.0159507694053127 0.145082280762891 GO:0019838 growth factor binding 10/623 136/18639 0.0735294117647059 2.19986309130394 0.0160179675461567 0.145082280762891 GO:0005539 glycosaminoglycan binding 15/623 242/18639 0.0619834710743802 1.8544300439091 0.0163911232966587 0.145172333668862 GO:0016835 carbon-oxygen lyase activity 7/623 79/18639 0.0886075949367089 2.65097425686247 0.0163963676351887 0.145172333668862 GO:0001968 fibronectin binding 4/623 30/18639 0.133333333333333 3.98908507223114 0.0169960138955006 0.147174274172027 GO:0033612 receptor serine/threonine kinase binding 4/623 30/18639 0.133333333333333 3.98908507223114 0.0169960138955006 0.147174274172027 GO:0048306 calcium-dependent protein binding 7/623 80/18639 0.0875 2.61783707865169 0.017468536362208 0.149336962975351 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/623 17/18639 0.176470588235294 5.27967141912945 0.0178143077660951 0.149336962975351 GO:0070492 oligosaccharide binding 3/623 17/18639 0.176470588235294 5.27967141912945 0.0178143077660951 0.149336962975351 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/623 18/18639 0.166666666666667 4.98635634028892 0.0208566764161109 0.17119855224891 GO:0035615 clathrin adaptor activity 3/623 18/18639 0.166666666666667 4.98635634028892 0.0208566764161109 0.17119855224891 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/623 48/18639 0.104166666666667 3.11647271268058 0.0215309931211674 0.174911572984329 GO:0015103 inorganic anion transmembrane transporter activity 11/623 165/18639 0.0666666666666667 1.99454253611557 0.0229787254175543 0.182927625084878 GO:1901681 sulfur compound binding 16/623 275/18639 0.0581818181818182 1.74069166788268 0.0229820239637094 0.182927625084878 GO:0140311 protein sequestering activity 4/623 33/18639 0.121212121212121 3.62644097475558 0.0234692542111491 0.183106656617678 GO:0140416 transcription regulator inhibitor activity 4/623 33/18639 0.121212121212121 3.62644097475558 0.0234692542111491 0.183106656617678 GO:0005520 insulin-like growth factor binding 3/623 19/18639 0.157894736842105 4.7239165329053 0.0241653809876995 0.184876895323371 GO:0070003 threonine-type peptidase activity 3/623 19/18639 0.157894736842105 4.7239165329053 0.0241653809876995 0.184876895323371 GO:0015035 protein-disulfide reductase activity 4/623 34/18639 0.117647058823529 3.5197809460863 0.0259160969044559 0.196364272699147 GO:0001972 retinoic acid binding 3/623 20/18639 0.15 4.48772070626003 0.0277402118573629 0.204292401342075 GO:0016408 C-acyltransferase activity 3/623 20/18639 0.15 4.48772070626003 0.0277402118573629 0.204292401342075 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/623 20/18639 0.15 4.48772070626003 0.0277402118573629 0.204292401342075 GO:0008509 monoatomic anion transmembrane transporter activity 10/623 149/18639 0.0671140939597315 2.00792872763312 0.0281661801348464 0.205508795798694 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/623 36/18639 0.111111111111111 3.32423756019262 0.0312535997530378 0.224189408448792 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/623 21/18639 0.142857142857143 4.27401972024765 0.0315799801241319 0.224189408448792 GO:0140312 cargo adaptor activity 3/623 21/18639 0.142857142857143 4.27401972024765 0.0315799801241319 0.224189408448792 GO:0003925 G protein activity 5/623 54/18639 0.0925925925925926 2.77019796682718 0.0338413561018035 0.238098112573403 GO:0008093 cytoskeletal anchor activity 3/623 22/18639 0.136363636363636 4.07974609660003 0.0356826061469718 0.248830917201892 GO:0005501 retinoid binding 4/623 38/18639 0.105263157894737 3.14927768860353 0.0371900180783989 0.25483247170242 GO:0019840 isoprenoid binding 4/623 38/18639 0.105263157894737 3.14927768860353 0.0371900180783989 0.25483247170242 GO:0030170 pyridoxal phosphate binding 5/623 56/18639 0.0892857142857143 2.67126232515478 0.0387438144651192 0.260680460491604 GO:0140297 DNA-binding transcription factor binding 24/623 488/18639 0.0491803278688525 1.47138383811804 0.0390109170787609 0.260680460491604 GO:0002020 protease binding 9/623 136/18639 0.0661764705882353 1.97987678217354 0.0390359065203164 0.260680460491604 GO:0017134 fibroblast growth factor binding 3/623 23/18639 0.130434782608696 3.90236583153046 0.040045202515149 0.262758170775948 GO:0016504 peptidase activator activity 5/623 57/18639 0.087719298245614 2.62439807383628 0.0413489961493713 0.262758170775948 GO:0070279 vitamin B6 binding 5/623 57/18639 0.087719298245614 2.62439807383628 0.0413489961493713 0.262758170775948 GO:0005528 FK506 binding 2/623 10/18639 0.2 5.98362760834671 0.0420146313677278 0.262758170775948 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/623 10/18639 0.2 5.98362760834671 0.0420146313677278 0.262758170775948 GO:0035374 chondroitin sulfate binding 2/623 10/18639 0.2 5.98362760834671 0.0420146313677278 0.262758170775948 GO:0050815 phosphoserine residue binding 2/623 10/18639 0.2 5.98362760834671 0.0420146313677278 0.262758170775948 GO:0097177 mitochondrial ribosome binding 2/623 10/18639 0.2 5.98362760834671 0.0420146313677278 0.262758170775948 GO:0044389 ubiquitin-like protein ligase binding 17/623 322/18639 0.0527950310559006 1.57952902704804 0.0433484574507777 0.268965232056794 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/623 40/18639 0.1 2.99181380417336 0.0437297830434888 0.269211476861478 GO:0005540 hyaluronic acid binding 3/623 24/18639 0.125 3.73976725521669 0.0446641517486796 0.27283218277488 GO:0000287 magnesium ion binding 13/623 230/18639 0.0565217391304348 1.6910251936632 0.0458988249745899 0.278217492922899 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/623 41/18639 0.0975609756097561 2.91884273577888 0.0472260626822154 0.28407738468386 GO:0000099 sulfur amino acid transmembrane transporter activity 2/623 11/18639 0.181818181818182 5.43966146213337 0.0502364691133818 0.288951369790839 GO:0010854 adenylate cyclase regulator activity 2/623 11/18639 0.181818181818182 5.43966146213337 0.0502364691133818 0.288951369790839 GO:0032794 GTPase activating protein binding 2/623 11/18639 0.181818181818182 5.43966146213337 0.0502364691133818 0.288951369790839 GO:0034713 type I transforming growth factor beta receptor binding 2/623 11/18639 0.181818181818182 5.43966146213337 0.0502364691133818 0.288951369790839 GO:0050786 RAGE receptor binding 2/623 11/18639 0.181818181818182 5.43966146213337 0.0502364691133818 0.288951369790839 GO:0070990 snRNP binding 2/623 11/18639 0.181818181818182 5.43966146213337 0.0502364691133818 0.288951369790839 GO:0016247 channel regulator activity 10/623 168/18639 0.0595238095238095 1.78084155010319 0.0559537341187006 0.319319915678459 GO:0004300 enoyl-CoA hydratase activity 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:0005527 macrolide binding 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:0015132 prostaglandin transmembrane transporter activity 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:0045295 gamma-catenin binding 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:0097371 MDM2/MDM4 family protein binding 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/623 12/18639 0.166666666666667 4.98635634028892 0.058978990882471 0.319319915678459 GO:1901682 sulfur compound transmembrane transporter activity 5/623 63/18639 0.0793650793650794 2.37445540013758 0.0591633346307805 0.319319915678459 GO:0141108 transporter regulator activity 10/623 170/18639 0.0588235294117647 1.75989047304315 0.0596575587223319 0.319796981450323 GO:0030291 protein serine/threonine kinase inhibitor activity 4/623 46/18639 0.0869565217391304 2.60157722102031 0.0669475256848015 0.350822502180681 GO:0005172 vascular endothelial growth factor receptor binding 2/623 13/18639 0.153846153846154 4.60279046795901 0.0681983262738659 0.350822502180681 GO:0008253 5'-nucleotidase activity 2/623 13/18639 0.153846153846154 4.60279046795901 0.0681983262738659 0.350822502180681 GO:0019855 calcium channel inhibitor activity 2/623 13/18639 0.153846153846154 4.60279046795901 0.0681983262738659 0.350822502180681 GO:0031994 insulin-like growth factor I binding 2/623 13/18639 0.153846153846154 4.60279046795901 0.0681983262738659 0.350822502180681 GO:0071714 icosanoid transmembrane transporter activity 2/623 13/18639 0.153846153846154 4.60279046795901 0.0681983262738659 0.350822502180681 GO:0008514 organic anion transmembrane transporter activity 14/623 269/18639 0.0520446096654275 1.5570778162984 0.0685617580403869 0.350822502180681 GO:0043021 ribonucleoprotein complex binding 10/623 177/18639 0.0564971751412429 1.6902902848437 0.0738582429952863 0.375485777292165 GO:1901612 cardiolipin binding 2/623 14/18639 0.142857142857143 4.27401972024765 0.0778529476740002 0.393257197225078 GO:0019001 guanyl nucleotide binding 19/623 400/18639 0.0475 1.42111155698234 0.0797496217037632 0.39773861963649 GO:0032561 guanyl ribonucleotide binding 19/623 400/18639 0.0475 1.42111155698234 0.0797496217037632 0.39773861963649 GO:0003714 transcription corepressor activity 11/623 204/18639 0.053921568627451 1.61323293362289 0.0814704979478345 0.403765738257192 GO:0031625 ubiquitin protein ligase binding 15/623 302/18639 0.0496688741721854 1.48600023386094 0.0831650306760517 0.409587776079555 GO:0072349 modified amino acid transmembrane transporter activity 3/623 31/18639 0.0967741935483871 2.89530368145809 0.083748989853496 0.409869868020717 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/623 70/18639 0.0714285714285714 2.13700986012382 0.0846678170189394 0.409869868020717 GO:0005525 GTP binding 18/623 378/18639 0.0476190476190476 1.42467324008255 0.0847960638847081 0.409869868020717 GO:0005006 epidermal growth factor receptor activity 4/623 50/18639 0.08 2.39345104333868 0.0853348697486508 0.409869868020717 GO:0044325 transmembrane transporter binding 8/623 136/18639 0.0588235294117647 1.75989047304315 0.0861130304123221 0.409869868020717 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/623 15/18639 0.133333333333333 3.98908507223114 0.0879035630653569 0.409869868020717 GO:0008252 nucleotidase activity 2/623 15/18639 0.133333333333333 3.98908507223114 0.0879035630653569 0.409869868020717 GO:0050780 dopamine receptor binding 2/623 15/18639 0.133333333333333 3.98908507223114 0.0879035630653569 0.409869868020717 GO:0140161 monocarboxylate:sodium symporter activity 2/623 15/18639 0.133333333333333 3.98908507223114 0.0879035630653569 0.409869868020717 GO:0099106 ion channel regulator activity 9/623 160/18639 0.05625 1.68289526484751 0.0887186862845496 0.411211569775619 GO:0042910 xenobiotic transmembrane transporter activity 3/623 32/18639 0.09375 2.80482544141252 0.0902228541402795 0.411211569775619 GO:0043425 bHLH transcription factor binding 3/623 32/18639 0.09375 2.80482544141252 0.0902228541402795 0.411211569775619 GO:0016830 carbon-carbon lyase activity 4/623 51/18639 0.0784313725490196 2.3465206307242 0.0902786821969317 0.411211569775619 GO:0001221 transcription coregulator binding 7/623 115/18639 0.0608695652173913 1.82110405471422 0.0908740315336954 0.411544464646851 GO:0030295 protein kinase activator activity 8/623 139/18639 0.0575539568345324 1.72190722542351 0.0947396301142499 0.42103616593323 GO:0005080 protein kinase C binding 4/623 52/18639 0.0769230769230769 2.3013952339795 0.0953565591202615 0.42103616593323 GO:0043539 protein serine/threonine kinase activator activity 5/623 73/18639 0.0684931506849315 2.04918753710504 0.0971126453993974 0.42103616593323 GO:0005159 insulin-like growth factor receptor binding 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0008142 oxysterol binding 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0015378 sodium:chloride symporter activity 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0034450 ubiquitin-ubiquitin ligase activity 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0043023 ribosomal large subunit binding 2/623 16/18639 0.125 3.73976725521669 0.0983130133651197 0.42103616593323 GO:0046943 carboxylic acid transmembrane transporter activity 10/623 188/18639 0.0531914893617021 1.59139032136881 0.100124241465247 0.423774875723208 GO:0004864 protein phosphatase inhibitor activity 4/623 53/18639 0.0754716981132075 2.25797268239498 0.100565865177969 0.423774875723208 GO:0005246 calcium channel regulator activity 4/623 53/18639 0.0754716981132075 2.25797268239498 0.100565865177969 0.423774875723208 GO:0005342 organic acid transmembrane transporter activity 10/623 189/18639 0.0529100529100529 1.58297026675839 0.102752005500953 0.430683937950805 GO:0016831 carboxy-lyase activity 3/623 34/18639 0.0882352941176471 2.63983570956472 0.103767451284361 0.432638897418393 GO:0017069 snRNA binding 4/623 54/18639 0.0740740740740741 2.21615837346174 0.105903825904063 0.436922590640845 GO:0050661 NADP binding 4/623 54/18639 0.0740740740740741 2.21615837346174 0.105903825904063 0.436922590640845 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/623 17/18639 0.117647058823529 3.5197809460863 0.109046174111656 0.44292982061848 GO:0031489 myosin V binding 2/623 17/18639 0.117647058823529 3.5197809460863 0.109046174111656 0.44292982061848 GO:0046965 nuclear retinoid X receptor binding 2/623 17/18639 0.117647058823529 3.5197809460863 0.109046174111656 0.44292982061848 GO:0005343 organic acid:sodium symporter activity 3/623 35/18639 0.0857142857142857 2.56441183214859 0.110822795656787 0.446674555197874 GO:0015108 chloride transmembrane transporter activity 7/623 121/18639 0.0578512396694215 1.73080137431516 0.111101792917238 0.446674555197874 GO:0019212 phosphatase inhibitor activity 4/623 56/18639 0.0714285714285714 2.13700986012382 0.116953978016744 0.465453205440375 GO:0170055 lipid transmembrane transporter activity 4/623 56/18639 0.0714285714285714 2.13700986012382 0.116953978016744 0.465453205440375 GO:0000400 four-way junction DNA binding 2/623 18/18639 0.111111111111111 3.32423756019262 0.120069861323599 0.466083993709342 GO:0003746 translation elongation factor activity 2/623 18/18639 0.111111111111111 3.32423756019262 0.120069861323599 0.466083993709342 GO:0015373 monoatomic anion:sodium symporter activity 2/623 18/18639 0.111111111111111 3.32423756019262 0.120069861323599 0.466083993709342 GO:0031690 adrenergic receptor binding 2/623 18/18639 0.111111111111111 3.32423756019262 0.120069861323599 0.466083993709342 GO:1901611 phosphatidylglycerol binding 2/623 18/18639 0.111111111111111 3.32423756019262 0.120069861323599 0.466083993709342 GO:0019209 kinase activator activity 8/623 148/18639 0.0540540540540541 1.61719665090452 0.123441832381961 0.4768243329264 GO:0015370 solute:sodium symporter activity 5/623 79/18639 0.0632911392405063 1.89355304061605 0.124572835285131 0.478845825388698 GO:0042805 actinin binding 3/623 37/18639 0.0810810810810811 2.42579497635677 0.125460164844445 0.479915582026322 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 4/623 58/18639 0.0689655172413793 2.06331986494714 0.12848241447877 0.489102138209037 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/623 19/18639 0.105263157894737 3.14927768860353 0.131352741363117 0.490475443775797 GO:0015245 fatty acid transmembrane transporter activity 2/623 19/18639 0.105263157894737 3.14927768860353 0.131352741363117 0.490475443775797 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/623 19/18639 0.105263157894737 3.14927768860353 0.131352741363117 0.490475443775797 GO:0030506 ankyrin binding 2/623 19/18639 0.105263157894737 3.14927768860353 0.131352741363117 0.490475443775797 GO:0000146 microfilament motor activity 3/623 38/18639 0.0789473684210526 2.36195826645265 0.133026177424391 0.490475443775797 GO:0042887 amide transmembrane transporter activity 3/623 38/18639 0.0789473684210526 2.36195826645265 0.133026177424391 0.490475443775797 GO:0001786 phosphatidylserine binding 4/623 59/18639 0.0677966101694915 2.02834834181244 0.13441785501092 0.490475443775797 GO:0004879 nuclear receptor activity 4/623 59/18639 0.0677966101694915 2.02834834181244 0.13441785501092 0.490475443775797 GO:0001618 virus receptor activity 5/623 81/18639 0.0617283950617284 1.84679864455145 0.134445045501995 0.490475443775797 GO:0140272 exogenous protein binding 5/623 82/18639 0.0609756097560976 1.8242767098618 0.139508392704166 0.504127752336657 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/623 60/18639 0.0666666666666667 1.99454253611557 0.140462930741813 0.504127752336657 GO:0098531 ligand-modulated transcription factor activity 4/623 60/18639 0.0666666666666667 1.99454253611557 0.140462930741813 0.504127752336657 GO:0000217 DNA secondary structure binding 3/623 39/18639 0.0769230769230769 2.3013952339795 0.140746326794498 0.504127752336657 GO:0010851 cyclase regulator activity 2/623 20/18639 0.1 2.99181380417336 0.142865244641534 0.504833241154839 GO:0030742 GTP-dependent protein binding 2/623 20/18639 0.1 2.99181380417336 0.142865244641534 0.504833241154839 GO:0043024 ribosomal small subunit binding 2/623 20/18639 0.1 2.99181380417336 0.142865244641534 0.504833241154839 GO:0005254 chloride channel activity 5/623 83/18639 0.0602409638554217 1.80229747239359 0.144654127748997 0.507589380974434 GO:0003924 GTPase activity 15/623 331/18639 0.0453172205438066 1.35580685989729 0.144933516141177 0.507589380974434 GO:0030246 carbohydrate binding 13/623 280/18639 0.0464285714285714 1.38905640908049 0.146561859689723 0.511020997502219 GO:0071855 neuropeptide receptor binding 3/623 40/18639 0.075 2.24386035313002 0.14861253304458 0.515888440701009 GO:0180051 translation factor activity 5/623 84/18639 0.0595238095238095 1.78084155010319 0.149880352440342 0.518007533872763 GO:0008373 sialyltransferase activity 2/623 21/18639 0.0952380952380952 2.8493464801651 0.154579483011787 0.529602750492558 GO:0051428 peptide hormone receptor binding 2/623 21/18639 0.0952380952380952 2.8493464801651 0.154579483011787 0.529602750492558 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/623 41/18639 0.0731707317073171 2.18913205183416 0.156616728073188 0.531956817765828 GO:0017080 sodium channel regulator activity 3/623 41/18639 0.0731707317073171 2.18913205183416 0.156616728073188 0.531956817765828 GO:0005507 copper ion binding 4/623 63/18639 0.0634920634920635 1.89956432011007 0.159220868304335 0.538480876497065 GO:0016859 cis-trans isomerase activity 3/623 42/18639 0.0714285714285714 2.13700986012382 0.164750875592768 0.553492432532641 GO:0015377 chloride:monoatomic cation symporter activity 2/623 22/18639 0.0909090909090909 2.71983073106669 0.166469170698269 0.553492432532641 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/623 22/18639 0.0909090909090909 2.71983073106669 0.166469170698269 0.553492432532641 GO:0031683 G-protein beta/gamma-subunit complex binding 2/623 22/18639 0.0909090909090909 2.71983073106669 0.166469170698269 0.553492432532641 GO:0043022 ribosome binding 6/623 112/18639 0.0535714285714286 1.60275739509287 0.172479557805584 0.570416349985512 GO:0008200 ion channel inhibitor activity 3/623 43/18639 0.0697674418604651 2.08731195640001 0.173006989399159 0.570416349985512 GO:0008083 growth factor activity 8/623 162/18639 0.0493827160493827 1.47743891564116 0.175981729903872 0.577806679851046 GO:0000295 adenine nucleotide transmembrane transporter activity 2/623 23/18639 0.0869565217391304 2.60157722102031 0.178509548620471 0.578870470423584 GO:0005283 amino acid:sodium symporter activity 2/623 23/18639 0.0869565217391304 2.60157722102031 0.178509548620471 0.578870470423584 GO:0043274 phospholipase binding 2/623 23/18639 0.0869565217391304 2.60157722102031 0.178509548620471 0.578870470423584 GO:0003954 NADH dehydrogenase activity 3/623 44/18639 0.0681818181818182 2.03987304830001 0.181377150011589 0.580996724427367 GO:0016248 channel inhibitor activity 3/623 44/18639 0.0681818181818182 2.03987304830001 0.181377150011589 0.580996724427367 GO:0019205 nucleobase-containing compound kinase activity 3/623 44/18639 0.0681818181818182 2.03987304830001 0.181377150011589 0.580996724427367 GO:0016500 protein-hormone receptor activity 4/623 67/18639 0.0597014925373134 1.78615749502887 0.185548891427171 0.591550085961779 GO:0046915 transition metal ion transmembrane transporter activity 3/623 45/18639 0.0666666666666667 1.99454253611557 0.189853519783764 0.591550085961779 GO:0141110 transporter inhibitor activity 3/623 45/18639 0.0666666666666667 1.99454253611557 0.189853519783764 0.591550085961779 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/623 24/18639 0.0833333333333333 2.49317817014446 0.190677311972452 0.591550085961779 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/623 24/18639 0.0833333333333333 2.49317817014446 0.190677311972452 0.591550085961779 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/623 24/18639 0.0833333333333333 2.49317817014446 0.190677311972452 0.591550085961779 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/623 24/18639 0.0833333333333333 2.49317817014446 0.190677311972452 0.591550085961779 GO:0050699 WW domain binding 2/623 24/18639 0.0833333333333333 2.49317817014446 0.190677311972452 0.591550085961779 GO:0015294 solute:monoatomic cation symporter activity 6/623 116/18639 0.0517241379310345 1.54748989871036 0.192516617356861 0.594793489316575 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 15/623 349/18639 0.0429799426934097 1.28587985852723 0.193232402620613 0.594793489316575 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/623 25/18639 0.08 2.39345104333868 0.20295054092557 0.612739564173753 GO:0015645 fatty acid ligase activity 2/623 25/18639 0.08 2.39345104333868 0.20295054092557 0.612739564173753 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/623 25/18639 0.08 2.39345104333868 0.20295054092557 0.612739564173753 GO:0042974 nuclear retinoic acid receptor binding 2/623 25/18639 0.08 2.39345104333868 0.20295054092557 0.612739564173753 GO:0120515 fatty acid-CoA ligase activity 2/623 25/18639 0.08 2.39345104333868 0.20295054092557 0.612739564173753 GO:0097110 scaffold protein binding 4/623 70/18639 0.0571428571428571 1.70960788809906 0.206152478847911 0.620031119588373 GO:0043495 protein-membrane adaptor activity 3/623 47/18639 0.0638297872340425 1.90966838564257 0.207094026116225 0.62049464859158 GO:0005126 cytokine receptor binding 12/623 275/18639 0.0436363636363636 1.30551875091201 0.21144853626023 0.625577135817401 GO:0140104 molecular carrier activity 11/623 249/18639 0.0441767068273092 1.32168481308863 0.213067372217628 0.625577135817401 GO:0005160 transforming growth factor beta receptor binding 2/623 26/18639 0.0769230769230769 2.3013952339795 0.215308634327125 0.625577135817401 GO:0008198 ferrous iron binding 2/623 26/18639 0.0769230769230769 2.3013952339795 0.215308634327125 0.625577135817401 GO:0015216 purine nucleotide transmembrane transporter activity 2/623 26/18639 0.0769230769230769 2.3013952339795 0.215308634327125 0.625577135817401 GO:0019865 immunoglobulin binding 2/623 26/18639 0.0769230769230769 2.3013952339795 0.215308634327125 0.625577135817401 GO:0097602 cullin family protein binding 2/623 26/18639 0.0769230769230769 2.3013952339795 0.215308634327125 0.625577135817401 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/623 48/18639 0.0625 1.86988362760835 0.21584301302264 0.625577135817401 GO:0051082 unfolded protein binding 6/623 121/18639 0.0495867768595041 1.48354403512728 0.218723561909318 0.625577135817401 GO:0005518 collagen binding 4/623 72/18639 0.0555555555555556 1.66211878009631 0.220239835668206 0.625577135817401 GO:0005004 GPI-linked ephrin receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0005008 hepatocyte growth factor receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0005009 insulin receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0005011 macrophage colony-stimulating factor receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0005020 stem cell factor receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0008288 boss receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0036332 placental growth factor receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0038062 protein tyrosine kinase collagen receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0060175 brain-derived neurotrophic factor receptor activity 3/623 49/18639 0.0612244897959184 1.83172273724899 0.224667930756757 0.625577135817401 GO:0008395 steroid hydroxylase activity 2/623 27/18639 0.0740740740740741 2.21615837346174 0.227732246272539 0.62745807714252 GO:0016405 CoA-ligase activity 2/623 27/18639 0.0740740740740741 2.21615837346174 0.227732246272539 0.62745807714252 GO:0023026 MHC class II protein complex binding 2/623 27/18639 0.0740740740740741 2.21615837346174 0.227732246272539 0.62745807714252 GO:0005007 fibroblast growth factor receptor activity 3/623 50/18639 0.06 1.79508828250401 0.233561530395572 0.636839051736025 GO:0005017 platelet-derived growth factor receptor activity 3/623 50/18639 0.06 1.79508828250401 0.233561530395572 0.636839051736025 GO:0005019 platelet-derived growth factor beta-receptor activity 3/623 50/18639 0.06 1.79508828250401 0.233561530395572 0.636839051736025 GO:0048029 monosaccharide binding 4/623 74/18639 0.0540540540540541 1.61719665090452 0.234573180729883 0.637391953155681 GO:0004252 serine-type endopeptidase activity 8/623 176/18639 0.0454545454545455 1.35991536553334 0.236696692022154 0.640951867056554 GO:0046966 nuclear thyroid hormone receptor binding 2/623 28/18639 0.0714285714285714 2.13700986012382 0.240203225433561 0.643445004126243 GO:0051393 alpha-actinin binding 2/623 28/18639 0.0714285714285714 2.13700986012382 0.240203225433561 0.643445004126243 GO:0097718 disordered domain specific binding 2/623 28/18639 0.0714285714285714 2.13700986012382 0.240203225433561 0.643445004126243 GO:0005010 insulin-like growth factor receptor activity 3/623 51/18639 0.0588235294117647 1.75989047304315 0.242516708407988 0.643445004126243 GO:0005021 vascular endothelial growth factor receptor activity 3/623 51/18639 0.0588235294117647 1.75989047304315 0.242516708407988 0.643445004126243 GO:0005030 neurotrophin receptor activity 3/623 51/18639 0.0588235294117647 1.75989047304315 0.242516708407988 0.643445004126243 GO:0017022 myosin binding 4/623 76/18639 0.0526315789473684 1.57463884430177 0.249122484434766 0.657153041819284 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/623 52/18639 0.0576923076923077 1.72604642548463 0.25152651346642 0.657153041819284 GO:0005416 amino acid:monoatomic cation symporter activity 2/623 29/18639 0.0689655172413793 2.06331986494714 0.252704557029551 0.657153041819284 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 6/623 128/18639 0.046875 1.40241272070626 0.257239590565305 0.657153041819284 GO:0005003 ephrin receptor activity 3/623 53/18639 0.0566037735849057 1.69347951179624 0.260584152363727 0.657153041819284 GO:0005005 transmembrane-ephrin receptor activity 3/623 53/18639 0.0566037735849057 1.69347951179624 0.260584152363727 0.657153041819284 GO:0005544 calcium-dependent phospholipid binding 3/623 53/18639 0.0566037735849057 1.69347951179624 0.260584152363727 0.657153041819284 GO:0038064 collagen receptor activity 3/623 53/18639 0.0566037735849057 1.69347951179624 0.260584152363727 0.657153041819284 GO:0005253 monoatomic anion channel activity 5/623 103/18639 0.0485436893203883 1.45233679814241 0.26166765914295 0.657153041819284 GO:0019199 transmembrane receptor protein kinase activity 4/623 78/18639 0.0512820512820513 1.53426348931967 0.263858099545532 0.657153041819284 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/623 30/18639 0.0666666666666667 1.99454253611557 0.265220307333396 0.657153041819284 GO:0015215 nucleotide transmembrane transporter activity 2/623 30/18639 0.0666666666666667 1.99454253611557 0.265220307333396 0.657153041819284 GO:0016769 transferase activity, transferring nitrogenous groups 2/623 30/18639 0.0666666666666667 1.99454253611557 0.265220307333396 0.657153041819284 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/623 54/18639 0.0555555555555556 1.66211878009631 0.269682995096648 0.657153041819284 GO:0046332 SMAD binding 4/623 79/18639 0.0506329113924051 1.51484243249284 0.271286646972754 0.657153041819284 GO:0016878 acid-thiol ligase activity 2/623 31/18639 0.0645161290322581 1.93020245430539 0.277735570607872 0.657153041819284 GO:0017147 Wnt-protein binding 2/623 31/18639 0.0645161290322581 1.93020245430539 0.277735570607872 0.657153041819284 GO:0047499 calcium-independent phospholipase A2 activity 2/623 31/18639 0.0645161290322581 1.93020245430539 0.277735570607872 0.657153041819284 GO:1901981 phosphatidylinositol phosphate binding 8/623 185/18639 0.0432432432432432 1.29375732072361 0.279047096721105 0.657153041819284 GO:0005179 hormone activity 6/623 132/18639 0.0454545454545455 1.35991536553334 0.280020486123344 0.657153041819284 GO:0004497 monooxygenase activity 5/623 106/18639 0.0471698113207547 1.41123292649687 0.280919809328595 0.657153041819284 GO:0015101 organic cation transmembrane transporter activity 4/623 81/18639 0.0493827160493827 1.47743891564116 0.286247302978404 0.657153041819284 GO:0001094 TFIID-class transcription factor complex binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0004090 carbonyl reductase (NADPH) activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0004955 prostaglandin receptor activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0005345 purine nucleobase transmembrane transporter activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0005381 iron ion transmembrane transporter activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0008401 retinoic acid 4-hydroxylase activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0008519 ammonium channel activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0015643 toxic substance binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0019911 structural constituent of myelin sheath 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0030957 Tat protein binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0032052 bile acid binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0042975 peroxisome proliferator activated receptor binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0140999 histone H3K4 trimethyltransferase activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:1905394 retromer complex binding 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:1990757 ubiquitin ligase activator activity 1/623 10/18639 0.1 2.99181380417336 0.288259993688933 0.657153041819284 GO:0047498 calcium-dependent phospholipase A2 activity 2/623 32/18639 0.0625 1.86988362760835 0.290236418372378 0.657153041819284 GO:0051059 NF-kappaB binding 2/623 32/18639 0.0625 1.86988362760835 0.290236418372378 0.657153041819284 GO:0001664 G protein-coupled receptor binding 12/623 297/18639 0.0404040404040404 1.20881365825186 0.291852906735047 0.657153041819284 GO:0008135 translation factor activity, RNA binding 4/623 83/18639 0.0481927710843374 1.44183797791487 0.301322666315408 0.657153041819284 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/623 33/18639 0.0606060606060606 1.81322048737779 0.302709850903938 0.657153041819284 GO:0005543 phospholipid binding 19/623 497/18639 0.0382293762575453 1.14375175612261 0.306361765200423 0.657153041819284 GO:0002162 dystroglycan binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0004954 prostanoid receptor activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0005536 D-glucose binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0008199 ferric iron binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0008271 secondary active sulfate transmembrane transporter activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0008432 JUN kinase binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0015173 aromatic amino acid transmembrane transporter activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0015205 nucleobase transmembrane transporter activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0015217 ADP transmembrane transporter activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0016594 glycine binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0019206 nucleoside kinase activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0019215 intermediate filament binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0019864 IgG binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0031731 CCR6 chemokine receptor binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0032050 clathrin heavy chain binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0034056 estrogen response element binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0042608 T cell receptor binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0047676 arachidonate-CoA ligase activity 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0048185 activin binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0048407 platelet-derived growth factor binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0050998 nitric-oxide synthase binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0070697 activin receptor binding 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/623 11/18639 0.0909090909090909 2.71983073106669 0.312062346146488 0.657153041819284 GO:0033218 amide binding 10/623 247/18639 0.0404858299595142 1.2112606494629 0.313271467209998 0.657153041819284 GO:1902936 phosphatidylinositol bisphosphate binding 5/623 111/18639 0.045045045045045 1.34766387575376 0.313565410817323 0.657153041819284 GO:0051427 hormone receptor binding 2/623 34/18639 0.0588235294117647 1.75989047304315 0.315143750880162 0.657865603444123 GO:0015459 potassium channel regulator activity 3/623 59/18639 0.0508474576271186 1.52126125635933 0.31557512449477 0.657865603444123 GO:0070851 growth factor receptor binding 6/623 139/18639 0.0431654676258993 1.29143041906764 0.320868720505267 0.667136020470054 GO:0008236 serine-type peptidase activity 8/623 194/18639 0.0412371134020619 1.23373765120551 0.323222222280487 0.670260818834274 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/623 86/18639 0.0465116279069767 1.39154130426668 0.324091185232119 0.670298829298977 GO:0004623 phospholipase A2 activity 2/623 35/18639 0.0571428571428571 1.70960788809906 0.327526839075518 0.671527596849035 GO:0005154 epidermal growth factor receptor binding 2/623 35/18639 0.0571428571428571 1.70960788809906 0.327526839075518 0.671527596849035 GO:0004032 aldose reductase (NADPH) activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0005049 nuclear export signal receptor activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0008504 monoamine transmembrane transporter activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0008603 cAMP-dependent protein kinase regulator activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0010853 cyclase activator activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0016208 AMP binding 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0016840 carbon-nitrogen lyase activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0031543 peptidyl-proline dioxygenase activity 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0042301 phosphate ion binding 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0097677 STAT family protein binding 1/623 12/18639 0.0833333333333333 2.49317817014446 0.335069923897763 0.671527596849035 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/623 88/18639 0.0454545454545455 1.35991536553334 0.339335558857778 0.671527596849035 GO:0004033 aldo-keto reductase (NADPH) activity 2/623 36/18639 0.0555555555555556 1.66211878009631 0.339848632025798 0.671527596849035 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/623 36/18639 0.0555555555555556 1.66211878009631 0.339848632025798 0.671527596849035 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/623 36/18639 0.0555555555555556 1.66211878009631 0.339848632025798 0.671527596849035 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/623 36/18639 0.0555555555555556 1.66211878009631 0.339848632025798 0.671527596849035 GO:0017124 SH3 domain binding 5/623 115/18639 0.0434782608695652 1.30078861051015 0.340024760333458 0.671527596849035 GO:0015179 L-amino acid transmembrane transporter activity 3/623 62/18639 0.0483870967741935 1.44765184072904 0.343218116863067 0.674543680239109 GO:0017171 serine hydrolase activity 8/623 198/18639 0.0404040404040404 1.20881365825186 0.343263979411019 0.674543680239109 GO:0019903 protein phosphatase binding 6/623 144/18639 0.0416666666666667 1.24658908507223 0.350558688559748 0.676826125662034 GO:0023023 MHC protein complex binding 2/623 37/18639 0.0540540540540541 1.61719665090452 0.352099401579018 0.676826125662034 GO:1990782 protein tyrosine kinase binding 5/623 117/18639 0.0427350427350427 1.27855290776639 0.353321481822732 0.676826125662034 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 18/623 484/18639 0.0371900826446281 1.11265802634546 0.354885694426838 0.676826125662034 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0039706 co-receptor binding 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0043560 insulin receptor substrate binding 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0045159 myosin II binding 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0046975 histone H3K36 methyltransferase activity 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0061459 L-arginine transmembrane transporter activity 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0071837 HMG box domain binding 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0097157 pre-mRNA intronic binding 1/623 13/18639 0.0769230769230769 2.3013952339795 0.357309223699754 0.676826125662034 GO:0015293 symporter activity 6/623 146/18639 0.0410958904109589 1.22951252226302 0.362504116684765 0.685019769658501 GO:0015291 secondary active transmembrane transporter activity 11/623 287/18639 0.0383275261324042 1.14668821762742 0.364850856039957 0.687804963060971 GO:0038024 cargo receptor activity 3/623 65/18639 0.0461538461538462 1.3808371403877 0.370766545606274 0.689374175357714 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/623 39/18639 0.0512820512820513 1.53426348931967 0.376352504333182 0.689374175357714 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/623 39/18639 0.0512820512820513 1.53426348931967 0.376352504333182 0.689374175357714 GO:0051213 dioxygenase activity 4/623 93/18639 0.043010752688172 1.28680163620359 0.377494440050438 0.689374175357714 GO:0001216 DNA-binding transcription activator activity 18/623 491/18639 0.0366598778004073 1.09679528462567 0.377718393185532 0.689374175357714 GO:0005313 L-glutamate transmembrane transporter activity 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0005347 ATP transmembrane transporter activity 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0008392 arachidonate epoxygenase activity 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0008494 translation activator activity 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0008559 ABC-type xenobiotic transporter activity 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0019763 immunoglobulin receptor activity 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0019992 diacylglycerol binding 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0032036 myosin heavy chain binding 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0070742 C2H2 zinc finger domain binding 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:1990825 sequence-specific mRNA binding 1/623 14/18639 0.0714285714285714 2.13700986012382 0.37880586031712 0.689374175357714 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/623 67/18639 0.0447761194029851 1.33961812127165 0.389016547409156 0.702394071626859 GO:0004089 carbonate dehydratase activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0004467 long-chain fatty acid-CoA ligase activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0004953 icosanoid receptor activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0005523 tropomyosin binding 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0008242 omega peptidase activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0015116 sulfate transmembrane transporter activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0016846 carbon-sulfur lyase activity 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0031005 filamin binding 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0051371 muscle alpha-actinin binding 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0120283 protein serine/threonine kinase binding 1/623 15/18639 0.0666666666666667 1.99454253611557 0.399584595835103 0.702394071626859 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/623 41/18639 0.0487804878048781 1.45942136788944 0.4002220027417 0.702394071626859 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/623 41/18639 0.0487804878048781 1.45942136788944 0.4002220027417 0.702394071626859 GO:0042169 SH2 domain binding 2/623 41/18639 0.0487804878048781 1.45942136788944 0.4002220027417 0.702394071626859 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 7/623 181/18639 0.0386740331491713 1.15705506238749 0.401836195434396 0.703659826671788 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 10/623 268/18639 0.0373134328358209 1.11634843439304 0.406844811553383 0.710850801561122 GO:0042626 ATPase-coupled transmembrane transporter activity 4/623 98/18639 0.0408163265306122 1.22114849149933 0.41543646245892 0.716081699859667 GO:0000062 fatty-acyl-CoA binding 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0005149 interleukin-1 receptor binding 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0008391 arachidonate monooxygenase activity 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0015562 efflux transmembrane transporter activity 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0016722 oxidoreductase activity, acting on metal ions 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0019841 retinol binding 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0070411 I-SMAD binding 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0097027 ubiquitin-protein transferase activator activity 1/623 16/18639 0.0625 1.86988362760835 0.419669367999768 0.716081699859667 GO:0042826 histone deacetylase binding 5/623 127/18639 0.0393700787401575 1.17787945046195 0.419834702201988 0.716081699859667 GO:0048156 tau protein binding 2/623 43/18639 0.0465116279069767 1.39154130426668 0.423653538108902 0.72103453138189 GO:0042379 chemokine receptor binding 3/623 72/18639 0.0416666666666667 1.24658908507223 0.433994164019863 0.724725970428086 GO:0001223 transcription coactivator binding 2/623 44/18639 0.0454545454545455 1.35991536553334 0.435190508970679 0.724725970428086 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/623 44/18639 0.0454545454545455 1.35991536553334 0.435190508970679 0.724725970428086 GO:0030547 signaling receptor inhibitor activity 2/623 44/18639 0.0454545454545455 1.35991536553334 0.435190508970679 0.724725970428086 GO:0043014 alpha-tubulin binding 2/623 44/18639 0.0454545454545455 1.35991536553334 0.435190508970679 0.724725970428086 GO:0004550 nucleoside diphosphate kinase activity 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0005092 GDP-dissociation inhibitor activity 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0008429 phosphatidylethanolamine binding 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0036041 long-chain fatty acid binding 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0070403 NAD+ binding 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:1901567 fatty acid derivative binding 1/623 17/18639 0.0588235294117647 1.75989047304315 0.439083317617775 0.724725970428086 GO:0016298 lipase activity 5/623 130/18639 0.0384615384615385 1.15069761698975 0.439618037899271 0.724725970428086 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/623 130/18639 0.0384615384615385 1.15069761698975 0.439618037899271 0.724725970428086 GO:0015171 amino acid transmembrane transporter activity 4/623 102/18639 0.0392156862745098 1.1732603153621 0.445417469049236 0.731646584195769 GO:0008009 chemokine activity 2/623 45/18639 0.0444444444444444 1.32969502407705 0.446601531723559 0.731646584195769 GO:0042605 peptide antigen binding 2/623 45/18639 0.0444444444444444 1.32969502407705 0.446601531723559 0.731646584195769 GO:0019902 phosphatase binding 7/623 190/18639 0.0368421052631579 1.10224719101124 0.451039157227925 0.734849529343795 GO:0001217 DNA-binding transcription repressor activity 10/623 278/18639 0.0359712230215827 1.0761920158897 0.451909780550143 0.734849529343795 GO:0005178 integrin binding 6/623 161/18639 0.0372670807453416 1.11496166615156 0.452023585744381 0.734849529343795 GO:0000900 mRNA regulatory element binding translation repressor activity 1/623 18/18639 0.0555555555555556 1.66211878009631 0.457848815046845 0.734849529343795 GO:0015172 acidic amino acid transmembrane transporter activity 1/623 18/18639 0.0555555555555556 1.66211878009631 0.457848815046845 0.734849529343795 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/623 18/18639 0.0555555555555556 1.66211878009631 0.457848815046845 0.734849529343795 GO:0016854 racemase and epimerase activity 1/623 18/18639 0.0555555555555556 1.66211878009631 0.457848815046845 0.734849529343795 GO:0070064 proline-rich region binding 1/623 18/18639 0.0555555555555556 1.66211878009631 0.457848815046845 0.734849529343795 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/623 46/18639 0.0434782608695652 1.30078861051015 0.457882130593659 0.734849529343795 GO:0030276 clathrin binding 2/623 46/18639 0.0434782608695652 1.30078861051015 0.457882130593659 0.734849529343795 GO:0019003 GDP binding 3/623 75/18639 0.04 1.19672552166934 0.460392336547863 0.737376343901862 GO:0051087 protein-folding chaperone binding 5/623 134/18639 0.0373134328358209 1.11634843439304 0.465740069095523 0.744428345734831 GO:0015297 antiporter activity 5/623 135/18639 0.037037037037037 1.10807918673087 0.472214834332494 0.747167607203101 GO:0008013 beta-catenin binding 4/623 106/18639 0.0377358490566038 1.12898634119749 0.474910673098273 0.747167607203101 GO:0016918 retinal binding 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0022840 leak channel activity 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0022842 narrow pore channel activity 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0042800 histone H3K4 methyltransferase activity 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0046624 sphingolipid transporter activity 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0050145 nucleoside monophosphate kinase activity 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0120227 acyl-CoA binding 1/623 19/18639 0.0526315789473684 1.57463884430177 0.475987485807052 0.747167607203101 GO:0032266 phosphatidylinositol-3-phosphate binding 2/623 48/18639 0.0416666666666667 1.24658908507223 0.480036323159468 0.751610396788471 GO:0019888 protein phosphatase regulator activity 4/623 107/18639 0.0373831775700935 1.11843506698069 0.482192676669065 0.751610396788471 GO:0051020 GTPase binding 11/623 315/18639 0.0349206349206349 1.04476037606054 0.484447341202524 0.751610396788471 GO:0016922 nuclear receptor binding 5/623 137/18639 0.0364963503649635 1.09190284823845 0.485087571685499 0.751610396788471 GO:0016874 ligase activity 6/623 167/18639 0.0359281437125748 1.07490316317606 0.487171293830715 0.751610396788471 GO:0004175 endopeptidase activity 14/623 405/18639 0.0345679012345679 1.03420724094881 0.487375327246977 0.751610396788471 GO:0001222 transcription corepressor binding 2/623 49/18639 0.0408163265306122 1.22114849149933 0.490903063261711 0.751610396788471 GO:0016763 pentosyltransferase activity 2/623 49/18639 0.0408163265306122 1.22114849149933 0.490903063261711 0.751610396788471 GO:0000339 RNA cap binding 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0015095 magnesium ion transmembrane transporter activity 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0016505 peptidase activator activity involved in apoptotic process 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0031418 L-ascorbic acid binding 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0042288 MHC class I protein binding 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0052745 inositol phosphate phosphatase activity 1/623 20/18639 0.05 1.49590690208668 0.493520235342079 0.751610396788471 GO:0004620 phospholipase activity 4/623 109/18639 0.036697247706422 1.09791332263242 0.49663440013325 0.751610396788471 GO:0015605 organophosphate ester transmembrane transporter activity 2/623 50/18639 0.04 1.19672552166934 0.501625627131134 0.751610396788471 GO:0048020 CCR chemokine receptor binding 2/623 50/18639 0.04 1.19672552166934 0.501625627131134 0.751610396788471 GO:0000049 tRNA binding 3/623 80/18639 0.0375 1.12193017656501 0.503147398308494 0.751610396788471 GO:0004713 protein tyrosine kinase activity 5/623 140/18639 0.0357142857142857 1.06850493006191 0.504184930390494 0.751610396788471 GO:0001846 opsonin binding 1/623 21/18639 0.0476190476190476 1.42467324008255 0.510467272958594 0.751610396788471 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/623 21/18639 0.0476190476190476 1.42467324008255 0.510467272958594 0.751610396788471 GO:0010314 phosphatidylinositol-5-phosphate binding 1/623 21/18639 0.0476190476190476 1.42467324008255 0.510467272958594 0.751610396788471 GO:0015174 basic amino acid transmembrane transporter activity 1/623 21/18639 0.0476190476190476 1.42467324008255 0.510467272958594 0.751610396788471 GO:1904047 S-adenosyl-L-methionine binding 1/623 21/18639 0.0476190476190476 1.42467324008255 0.510467272958594 0.751610396788471 GO:0033192 calmodulin-dependent protein phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0140791 histone H2AXS140 phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/623 81/18639 0.037037037037037 1.10807918673087 0.511489709667344 0.751610396788471 GO:0003743 translation initiation factor activity 2/623 51/18639 0.0392156862745098 1.1732603153621 0.512201501364732 0.751610396788471 GO:0016597 amino acid binding 2/623 51/18639 0.0392156862745098 1.1732603153621 0.512201501364732 0.751610396788471 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/623 82/18639 0.0365853658536585 1.09456602591708 0.519757456542047 0.759868044072603 GO:0033549 MAP kinase phosphatase activity 3/623 82/18639 0.0365853658536585 1.09456602591708 0.519757456542047 0.759868044072603 GO:0030159 signaling receptor complex adaptor activity 2/623 52/18639 0.0384615384615385 1.15069761698975 0.522628500880664 0.760047223493962 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/623 22/18639 0.0454545454545455 1.35991536553334 0.52684813497099 0.760047223493962 GO:0016881 acid-amino acid ligase activity 1/623 22/18639 0.0454545454545455 1.35991536553334 0.52684813497099 0.760047223493962 GO:0033691 sialic acid binding 1/623 22/18639 0.0454545454545455 1.35991536553334 0.52684813497099 0.760047223493962 GO:0034062 5'-3' RNA polymerase activity 1/623 22/18639 0.0454545454545455 1.35991536553334 0.52684813497099 0.760047223493962 GO:0070034 telomerase RNA binding 1/623 22/18639 0.0454545454545455 1.35991536553334 0.52684813497099 0.760047223493962 GO:0097747 RNA polymerase activity 1/623 22/18639 0.0454545454545455 1.35991536553334 0.52684813497099 0.760047223493962 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/623 83/18639 0.036144578313253 1.08137848343615 0.527948761175546 0.760047223493962 GO:0017046 peptide hormone binding 2/623 53/18639 0.0377358490566038 1.12898634119749 0.532904749842112 0.760047223493962 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/623 53/18639 0.0377358490566038 1.12898634119749 0.532904749842112 0.760047223493962 GO:0017018 myosin phosphatase activity 3/623 84/18639 0.0357142857142857 1.06850493006191 0.536061871515042 0.760047223493962 GO:0051117 ATPase binding 3/623 84/18639 0.0357142857142857 1.06850493006191 0.536061871515042 0.760047223493962 GO:0035401 histone H3Y41 kinase activity 4/623 115/18639 0.0347826086956522 1.04063088840812 0.538866312422594 0.760047223493962 GO:0140801 histone H2AXY142 kinase activity 4/623 115/18639 0.0347826086956522 1.04063088840812 0.538866312422594 0.760047223493962 GO:0005516 calmodulin binding 7/623 207/18639 0.0338164251207729 1.01172447484123 0.541249163743914 0.760047223493962 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0005212 structural constituent of eye lens 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0008171 O-methyltransferase activity 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0016493 C-C chemokine receptor activity 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0031681 G-protein beta-subunit binding 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0070577 lysine-acetylated histone binding 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0099186 structural constituent of postsynapse 1/623 23/18639 0.0434782608695652 1.30078861051015 0.542681707077831 0.760047223493962 GO:0015485 cholesterol binding 2/623 54/18639 0.037037037037037 1.10807918673087 0.543028663486169 0.760047223493962 GO:0140463 chromatin-protein adaptor activity 2/623 54/18639 0.037037037037037 1.10807918673087 0.543028663486169 0.760047223493962 GO:0005319 lipid transporter activity 6/623 178/18639 0.0337078651685393 1.0084765632045 0.549529358056558 0.763356183757674 GO:0019208 phosphatase regulator activity 4/623 117/18639 0.0341880341880342 1.02284232621311 0.55254143089322 0.763356183757674 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0004622 lysophospholipase activity 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0005315 phosphate transmembrane transporter activity 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0015149 hexose transmembrane transporter activity 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0015295 solute:proton symporter activity 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0019957 C-C chemokine binding 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0030215 semaphorin receptor binding 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0055056 D-glucose transmembrane transporter activity 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0070300 phosphatidic acid binding 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0070840 dynein complex binding 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0140033 acetylation-dependent protein binding 1/623 24/18639 0.0416666666666667 1.24658908507223 0.557986245995457 0.763356183757674 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/623 57/18639 0.0350877192982456 1.04975922953451 0.572474553350085 0.778189943955542 GO:0001848 complement binding 1/623 25/18639 0.04 1.19672552166934 0.572779400373369 0.778189943955542 GO:0015662 P-type ion transporter activity 1/623 25/18639 0.04 1.19672552166934 0.572779400373369 0.778189943955542 GO:0140358 P-type transmembrane transporter activity 1/623 25/18639 0.04 1.19672552166934 0.572779400373369 0.778189943955542 GO:0046982 protein heterodimerization activity 12/623 369/18639 0.032520325203252 0.972947578592961 0.579970018342682 0.784097705152529 GO:0001637 G protein-coupled chemoattractant receptor activity 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0004950 chemokine receptor activity 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0015145 monosaccharide transmembrane transporter activity 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0030507 spectrin binding 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0034237 protein kinase A regulatory subunit binding 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0050750 low-density lipoprotein particle receptor binding 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0070412 R-SMAD binding 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0120014 phospholipid transfer activity 1/623 26/18639 0.0384615384615385 1.15069761698975 0.587078231015219 0.784097705152529 GO:0045309 protein phosphorylated amino acid binding 2/623 59/18639 0.0338983050847458 1.01417417090622 0.591325998291697 0.785254715717376 GO:0043178 alcohol binding 3/623 92/18639 0.0326086956521739 0.975591457882616 0.597980215125173 0.785254715717376 GO:0001098 basal transcription machinery binding 2/623 60/18639 0.0333333333333333 0.997271268057785 0.600516841138137 0.785254715717376 GO:0001099 basal RNA polymerase II transcription machinery binding 2/623 60/18639 0.0333333333333333 0.997271268057785 0.600516841138137 0.785254715717376 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/623 60/18639 0.0333333333333333 0.997271268057785 0.600516841138137 0.785254715717376 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/623 60/18639 0.0333333333333333 0.997271268057785 0.600516841138137 0.785254715717376 GO:0001671 ATPase activator activity 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0005044 scavenger receptor activity 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0005104 fibroblast growth factor receptor binding 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0005385 zinc ion transmembrane transporter activity 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0035255 ionotropic glutamate receptor binding 1/623 27/18639 0.037037037037037 1.10807918673087 0.600899230428398 0.785254715717376 GO:0051219 phosphoprotein binding 3/623 93/18639 0.032258064516129 0.965101227152695 0.605329740960998 0.788331552571513 GO:0015026 coreceptor activity 2/623 61/18639 0.0327868852459016 0.980922558745362 0.609551051760649 0.788331552571513 GO:0035091 phosphatidylinositol binding 9/623 284/18639 0.0316901408450704 0.948110008364796 0.611803078258737 0.788331552571513 GO:0016410 N-acyltransferase activity 3/623 94/18639 0.0319148936170213 0.954834192821283 0.612589697382019 0.788331552571513 GO:0042562 hormone binding 3/623 94/18639 0.0319148936170213 0.954834192821283 0.612589697382019 0.788331552571513 GO:0016866 intramolecular transferase activity 1/623 28/18639 0.0357142857142857 1.06850493006191 0.614258341724504 0.788331552571513 GO:0045499 chemorepellent activity 1/623 28/18639 0.0357142857142857 1.06850493006191 0.614258341724504 0.788331552571513 GO:0046875 ephrin receptor binding 1/623 28/18639 0.0357142857142857 1.06850493006191 0.614258341724504 0.788331552571513 GO:0051119 sugar transmembrane transporter activity 1/623 28/18639 0.0357142857142857 1.06850493006191 0.614258341724504 0.788331552571513 GO:0051959 dynein light intermediate chain binding 1/623 28/18639 0.0357142857142857 1.06850493006191 0.614258341724504 0.788331552571513 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/623 28/18639 0.0357142857142857 1.06850493006191 0.614258341724504 0.788331552571513 GO:0003785 actin monomer binding 1/623 29/18639 0.0344827586206897 1.03165993247357 0.62717097689218 0.799693737525952 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/623 29/18639 0.0344827586206897 1.03165993247357 0.62717097689218 0.799693737525952 GO:0051861 glycolipid binding 1/623 29/18639 0.0344827586206897 1.03165993247357 0.62717097689218 0.799693737525952 GO:0097472 cyclin-dependent protein kinase activity 1/623 29/18639 0.0344827586206897 1.03165993247357 0.62717097689218 0.799693737525952 GO:0098918 structural constituent of synapse 1/623 30/18639 0.0333333333333333 0.997271268057785 0.639652034463173 0.814290473597706 GO:0015081 sodium ion transmembrane transporter activity 5/623 164/18639 0.0304878048780488 0.912138354930901 0.644578958352557 0.819062427869611 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7/623 229/18639 0.0305676855895196 0.914528237083558 0.647677366257636 0.819062427869611 GO:0005164 tumor necrosis factor receptor binding 1/623 31/18639 0.032258064516129 0.965101227152695 0.651715916591683 0.819062427869611 GO:0005184 neuropeptide hormone activity 1/623 31/18639 0.032258064516129 0.965101227152695 0.651715916591683 0.819062427869611 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/623 31/18639 0.032258064516129 0.965101227152695 0.651715916591683 0.819062427869611 GO:0005452 solute:inorganic anion antiporter activity 1/623 31/18639 0.032258064516129 0.965101227152695 0.651715916591683 0.819062427869611 GO:0070273 phosphatidylinositol-4-phosphate binding 1/623 31/18639 0.032258064516129 0.965101227152695 0.651715916591683 0.819062427869611 GO:0070325 lipoprotein particle receptor binding 1/623 31/18639 0.032258064516129 0.965101227152695 0.651715916591683 0.819062427869611 GO:0043130 ubiquitin binding 3/623 100/18639 0.03 0.897544141252006 0.654240748266194 0.820926289225734 GO:0031369 translation initiation factor binding 1/623 32/18639 0.03125 0.934941813804173 0.663376545566499 0.827121389092408 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/623 32/18639 0.03125 0.934941813804173 0.663376545566499 0.827121389092408 GO:0140142 nucleocytoplasmic carrier activity 1/623 32/18639 0.03125 0.934941813804173 0.663376545566499 0.827121389092408 GO:0160041 neuropeptide activity 1/623 32/18639 0.03125 0.934941813804173 0.663376545566499 0.827121389092408 GO:0030145 manganese ion binding 2/623 68/18639 0.0294117647058824 0.879945236521575 0.668439564564881 0.830805010847202 GO:0032934 sterol binding 2/623 68/18639 0.0294117647058824 0.879945236521575 0.668439564564881 0.830805010847202 GO:0005125 cytokine activity 7/623 234/18639 0.0299145299145299 0.894987035436474 0.669737953648057 0.83110788578688 GO:0004722 protein serine/threonine phosphatase activity 3/623 103/18639 0.029126213592233 0.871402078885443 0.673826565598961 0.833263534894149 GO:0019956 chemokine binding 1/623 33/18639 0.0303030303030303 0.906610243688895 0.674647379774704 0.833263534894149 GO:0071889 14-3-3 protein binding 1/623 33/18639 0.0303030303030303 0.906610243688895 0.674647379774704 0.833263534894149 GO:0016782 transferase activity, transferring sulphur-containing groups 2/623 70/18639 0.0285714285714286 0.85480394404953 0.683889922562954 0.841443374078652 GO:0008376 acetylgalactosaminyltransferase activity 1/623 34/18639 0.0294117647058824 0.879945236521575 0.685541429135145 0.841443374078652 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/623 34/18639 0.0294117647058824 0.879945236521575 0.685541429135145 0.841443374078652 GO:0030332 cyclin binding 1/623 34/18639 0.0294117647058824 0.879945236521575 0.685541429135145 0.841443374078652 GO:0016229 steroid dehydrogenase activity 1/623 35/18639 0.0285714285714286 0.85480394404953 0.696071270019252 0.849508185560852 GO:0061631 ubiquitin conjugating enzyme activity 1/623 35/18639 0.0285714285714286 0.85480394404953 0.696071270019252 0.849508185560852 GO:0140566 histone reader activity 1/623 35/18639 0.0285714285714286 0.85480394404953 0.696071270019252 0.849508185560852 GO:0016791 phosphatase activity 8/623 273/18639 0.0293040293040293 0.876721993896954 0.696424223188211 0.849508185560852 GO:0000993 RNA polymerase II complex binding 1/623 36/18639 0.0277777777777778 0.831059390048154 0.706249059676208 0.857510414522113 GO:0016409 palmitoyltransferase activity 1/623 36/18639 0.0277777777777778 0.831059390048154 0.706249059676208 0.857510414522113 GO:0045505 dynein intermediate chain binding 1/623 36/18639 0.0277777777777778 0.831059390048154 0.706249059676208 0.857510414522113 GO:0030280 structural constituent of skin epidermis 1/623 37/18639 0.027027027027027 0.808598325452258 0.716086550178907 0.86572828012235 GO:0030551 cyclic nucleotide binding 1/623 37/18639 0.027027027027027 0.808598325452258 0.716086550178907 0.86572828012235 GO:0004222 metalloendopeptidase activity 3/623 110/18639 0.0272727272727273 0.815949219320006 0.716313247004787 0.86572828012235 GO:0003725 double-stranded RNA binding 2/623 75/18639 0.0266666666666667 0.797817014446228 0.719939258302049 0.867449748535191 GO:0044183 protein folding chaperone 2/623 75/18639 0.0266666666666667 0.797817014446228 0.719939258302049 0.867449748535191 GO:0003724 RNA helicase activity 2/623 77/18639 0.025974025974026 0.777094494590482 0.733360064425641 0.882271344683061 GO:0015144 carbohydrate transmembrane transporter activity 1/623 40/18639 0.025 0.747953451043339 0.743668949860817 0.889242993156789 GO:0061791 GTPase motor activity 1/623 40/18639 0.025 0.747953451043339 0.743668949860817 0.889242993156789 GO:0140662 ATP-dependent protein folding chaperone 1/623 40/18639 0.025 0.747953451043339 0.743668949860817 0.889242993156789 GO:1990606 membrane scission GTPase motor activity 1/623 40/18639 0.025 0.747953451043339 0.743668949860817 0.889242993156789 GO:0008186 ATP-dependent activity, acting on RNA 2/623 79/18639 0.0253164556962025 0.757421216246419 0.74623005949395 0.890953464971565 GO:0042287 MHC protein binding 1/623 41/18639 0.024390243902439 0.729710683944721 0.752255123538795 0.894083012592112 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/623 41/18639 0.024390243902439 0.729710683944721 0.752255123538795 0.894083012592112 GO:0140318 protein transporter activity 1/623 41/18639 0.024390243902439 0.729710683944721 0.752255123538795 0.894083012592112 GO:0003774 cytoskeletal motor activity 4/623 153/18639 0.0261437908496732 0.782173543574733 0.756573674701104 0.897180629037163 GO:0019894 kinesin binding 1/623 42/18639 0.0238095238095238 0.712336620041275 0.760554137305615 0.897180629037163 GO:0031492 nucleosomal DNA binding 1/623 42/18639 0.0238095238095238 0.712336620041275 0.760554137305615 0.897180629037163 GO:0035198 miRNA binding 1/623 42/18639 0.0238095238095238 0.712336620041275 0.760554137305615 0.897180629037163 GO:0043175 RNA polymerase core enzyme binding 1/623 42/18639 0.0238095238095238 0.712336620041275 0.760554137305615 0.897180629037163 GO:0032182 ubiquitin-like protein binding 3/623 120/18639 0.025 0.747953451043339 0.769400314333976 0.906053328156227 GO:0030165 PDZ domain binding 2/623 83/18639 0.0240963855421687 0.720918988957435 0.770375291706436 0.906053328156227 GO:0001046 core promoter sequence-specific DNA binding 1/623 44/18639 0.0227272727272727 0.679957682766672 0.776328721333701 0.910807528437749 GO:0003730 mRNA 3'-UTR binding 7/623 262/18639 0.0267175572519084 0.799339566000515 0.776729262830161 0.910807528437749 GO:0008528 G protein-coupled peptide receptor activity 3/623 122/18639 0.0245901639344262 0.735691919059022 0.778986602946929 0.91209724089477 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/623 45/18639 0.0222222222222222 0.664847512038523 0.783822521097568 0.916397843657097 GO:0016757 glycosyltransferase activity 7/623 267/18639 0.0262172284644195 0.784370660270168 0.792833026396918 0.925559147852995 GO:0004197 cysteine-type endopeptidase activity 2/623 88/18639 0.0227272727272727 0.679957682766672 0.797722330070058 0.927546261390295 GO:0140359 ABC-type transporter activity 1/623 47/18639 0.0212765957446809 0.636556128547522 0.798066453328198 0.927546261390295 GO:0140938 histone H3 methyltransferase activity 1/623 47/18639 0.0212765957446809 0.636556128547522 0.798066453328198 0.927546261390295 GO:0008188 neuropeptide receptor activity 1/623 48/18639 0.0208333333333333 0.623294542536116 0.804833051842427 0.932397931906273 GO:0140693 molecular condensate scaffold activity 1/623 48/18639 0.0208333333333333 0.623294542536116 0.804833051842427 0.932397931906273 GO:0001653 peptide receptor activity 3/623 128/18639 0.0234375 0.70120636035313 0.805790598512909 0.932397931906273 GO:0035591 signaling adaptor activity 3/623 129/18639 0.0232558139534884 0.695770652133338 0.809981677035153 0.934739954431334 GO:0035254 glutamate receptor binding 1/623 49/18639 0.0204081632653061 0.610574245749664 0.811373259937858 0.934739954431334 GO:0060590 ATPase regulator activity 1/623 49/18639 0.0204081632653061 0.610574245749664 0.811373259937858 0.934739954431334 GO:0032813 tumor necrosis factor receptor superfamily binding 1/623 50/18639 0.02 0.598362760834671 0.81769464019922 0.940647264929905 GO:0030544 Hsp70 protein binding 1/623 51/18639 0.0196078431372549 0.58663015768105 0.82380450297591 0.94629438534259 GO:0015631 tubulin binding 10/623 385/18639 0.025974025974026 0.777094494590482 0.832578987490733 0.950034028507926 GO:0008146 sulfotransferase activity 1/623 53/18639 0.0188679245283019 0.564493170598746 0.835417706415152 0.950034028507926 GO:0034212 protein N-acetyltransferase activity 1/623 53/18639 0.0188679245283019 0.564493170598746 0.835417706415152 0.950034028507926 GO:0051018 protein kinase A binding 1/623 53/18639 0.0188679245283019 0.564493170598746 0.835417706415152 0.950034028507926 GO:0140296 general transcription initiation factor binding 1/623 53/18639 0.0188679245283019 0.564493170598746 0.835417706415152 0.950034028507926 GO:0004896 cytokine receptor activity 2/623 96/18639 0.0208333333333333 0.623294542536116 0.835499469233493 0.950034028507926 GO:0016407 acetyltransferase activity 2/623 96/18639 0.0208333333333333 0.623294542536116 0.835499469233493 0.950034028507926 GO:0140789 histone phosphatase activity 3/623 136/18639 0.0220588235294118 0.659958927391181 0.837225815536188 0.950625277582877 GO:0031267 small GTPase binding 7/623 283/18639 0.0247349823321555 0.740024615873268 0.838478157169125 0.950677392588879 GO:0004721 phosphoprotein phosphatase activity 4/623 175/18639 0.0228571428571429 0.683843155239624 0.840738113664506 0.951870163171884 GO:0042277 peptide binding 6/623 249/18639 0.0240963855421687 0.720918988957435 0.842900256788824 0.952948927330837 GO:0008374 O-acyltransferase activity 1/623 55/18639 0.0181818181818182 0.543966146213337 0.846266620624693 0.955384093198077 GO:0140767 enzyme-substrate adaptor activity 3/623 139/18639 0.0215827338129496 0.645715209533818 0.847831475657346 0.955781406034318 GO:0008238 exopeptidase activity 2/623 102/18639 0.0196078431372549 0.58663015768105 0.859519768737508 0.966437556923993 GO:0008408 3'-5' exonuclease activity 1/623 58/18639 0.0172413793103448 0.515829966236785 0.861215907415846 0.966437556923993 GO:0061980 regulatory RNA binding 1/623 58/18639 0.0172413793103448 0.515829966236785 0.861215907415846 0.966437556923993 GO:0019955 cytokine binding 3/623 144/18639 0.0208333333333333 0.623294542536116 0.864174904739556 0.966437556923993 GO:0036002 pre-mRNA binding 1/623 59/18639 0.0169491525423729 0.507087085453111 0.86586918171109 0.966437556923993 GO:0070063 RNA polymerase binding 1/623 59/18639 0.0169491525423729 0.507087085453111 0.86586918171109 0.966437556923993 GO:0070888 E-box binding 1/623 59/18639 0.0169491525423729 0.507087085453111 0.86586918171109 0.966437556923993 GO:0000149 SNARE binding 2/623 106/18639 0.0188679245283019 0.564493170598746 0.87370516999143 0.972885562546851 GO:0019905 syntaxin binding 1/623 61/18639 0.0163934426229508 0.490461279372681 0.874713606129742 0.972885562546851 GO:0008234 cysteine-type peptidase activity 4/623 187/18639 0.0213903743315508 0.639960172015691 0.875350081022484 0.972885562546851 GO:0005496 steroid binding 2/623 108/18639 0.0185185185185185 0.554039593365436 0.880292500330182 0.9770006905073 GO:0004536 DNA nuclease activity 1/623 64/18639 0.015625 0.467470906902087 0.886900462687852 0.98295016117866 GO:0120013 lipid transfer activity 1/623 65/18639 0.0153846153846154 0.460279046795901 0.890693787680879 0.985767843669287 GO:0140375 immune receptor activity 3/623 156/18639 0.0192307692307692 0.575348808494876 0.897244866788594 0.990963632698396 GO:0042054 histone methyltransferase activity 1/623 67/18639 0.0149253731343284 0.446539373757217 0.897903596125196 0.990963632698396 GO:0005548 phospholipid transporter activity 1/623 68/18639 0.0147058823529412 0.439972618260787 0.901328432417141 0.991453665630286 GO:0008017 microtubule binding 6/623 276/18639 0.0217391304347826 0.650394305255077 0.902908679035901 0.991453665630286 GO:0002039 p53 binding 1/623 69/18639 0.0144927536231884 0.433596203503385 0.904638560391086 0.991453665630286 GO:0008080 N-acetyltransferase activity 1/623 69/18639 0.0144927536231884 0.433596203503385 0.904638560391086 0.991453665630286 GO:0016279 protein-lysine N-methyltransferase activity 1/623 69/18639 0.0144927536231884 0.433596203503385 0.904638560391086 0.991453665630286 GO:0016278 lysine N-methyltransferase activity 1/623 70/18639 0.0142857142857143 0.427401972024765 0.907837816011783 0.993578054190674 GO:0003697 single-stranded DNA binding 2/623 121/18639 0.0165289256198347 0.494514678375761 0.915922448332042 0.999842050055206 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/623 122/18639 0.0163934426229508 0.490461279372681 0.918204712421794 0.999842050055206 GO:0003684 damaged DNA binding 1/623 74/18639 0.0135135135135135 0.404299162726129 0.919598440168518 0.999842050055206 GO:0031491 nucleosome binding 1/623 74/18639 0.0135135135135135 0.404299162726129 0.919598440168518 0.999842050055206 GO:0042578 phosphoric ester hydrolase activity 8/623 363/18639 0.0220385674931129 0.659352904501015 0.921742511137456 0.999842050055206 GO:0008094 ATP-dependent activity, acting on DNA 4/623 210/18639 0.019047619047619 0.56986929603302 0.923847578358003 0.999842050055206 GO:0051540 metal cluster binding 1/623 77/18639 0.012987012987013 0.388547247295241 0.927424550618197 0.999842050055206 GO:0016741 transferase activity, transferring one-carbon groups 4/623 215/18639 0.0186046511627907 0.556616521706671 0.931831721794767 0.999842050055206 GO:0031072 heat shock protein binding 2/623 131/18639 0.0152671755725191 0.456765466286008 0.936276868363458 0.999842050055206 GO:0030971 receptor tyrosine kinase binding 1/623 81/18639 0.0123456790123457 0.369359728910291 0.936689068433044 0.999842050055206 GO:0001540 amyloid-beta binding 1/623 83/18639 0.0120481927710843 0.360459494478717 0.940868579490591 0.999842050055206 GO:0004527 exonuclease activity 1/623 84/18639 0.0119047619047619 0.356168310020637 0.942853860530544 0.999842050055206 GO:0050660 flavin adenine dinucleotide binding 1/623 86/18639 0.0116279069767442 0.347885326066669 0.946626998502485 0.999842050055206 GO:0008237 metallopeptidase activity 3/623 184/18639 0.016304347826087 0.487795728941308 0.948002988268368 0.999842050055206 GO:0003727 single-stranded RNA binding 1/623 89/18639 0.0112359550561798 0.336158854401501 0.951825455027462 0.999842050055206 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/623 89/18639 0.0112359550561798 0.336158854401501 0.951825455027462 0.999842050055206 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/623 89/18639 0.0112359550561798 0.336158854401501 0.951825455027462 0.999842050055206 GO:0140793 histone H2AXY142 phosphatase activity 1/623 90/18639 0.0111111111111111 0.332423756019262 0.953443392575596 0.999842050055206 GO:0045182 translation regulator activity 7/623 356/18639 0.0196629213483146 0.588277995202626 0.955642164012402 0.999842050055206 GO:0052689 carboxylic ester hydrolase activity 1/623 92/18639 0.0108695652173913 0.325197152627539 0.956518322180243 0.999842050055206 GO:0008276 protein methyltransferase activity 1/623 95/18639 0.0105263157894737 0.314927768860353 0.960754701044216 0.999842050055206 GO:0016758 hexosyltransferase activity 3/623 197/18639 0.0152284263959391 0.455606163072085 0.962560702674159 0.999842050055206 GO:0000510 H3-H4 histone complex chaperone activity 2/623 151/18639 0.0132450331125828 0.396266729029583 0.96382742928273 0.999842050055206 GO:0140584 chromatin extrusion motor activity 2/623 151/18639 0.0132450331125828 0.396266729029583 0.96382742928273 0.999842050055206 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/623 151/18639 0.0132450331125828 0.396266729029583 0.96382742928273 0.999842050055206 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/623 151/18639 0.0132450331125828 0.396266729029583 0.96382742928273 0.999842050055206 GO:0004725 protein tyrosine phosphatase activity 1/623 98/18639 0.0102040816326531 0.305287122874832 0.96457893110489 0.999842050055206 GO:0008170 N-methyltransferase activity 1/623 98/18639 0.0102040816326531 0.305287122874832 0.96457893110489 0.999842050055206 GO:0030527 structural constituent of chromatin 1/623 98/18639 0.0102040816326531 0.305287122874832 0.96457893110489 0.999842050055206 GO:0015616 DNA translocase activity 2/623 152/18639 0.0131578947368421 0.393659711075441 0.964850164939927 0.999842050055206 GO:0140674 ATP-dependent histone chaperone activity 2/623 152/18639 0.0131578947368421 0.393659711075441 0.964850164939927 0.999842050055206 GO:0061775 cohesin loader activity 2/623 153/18639 0.0130718954248366 0.391086771787367 0.965845091275572 0.999842050055206 GO:0046873 metal ion transmembrane transporter activity 9/623 450/18639 0.02 0.598362760834671 0.967136148323675 0.999842050055206 GO:0042393 histone binding 4/623 247/18639 0.0161943319838057 0.484504259785159 0.967330168642347 0.999842050055206 GO:0004386 helicase activity 2/623 155/18639 0.0129032258064516 0.386040490861078 0.96775434934188 0.999842050055206 GO:0008168 methyltransferase activity 3/623 204/18639 0.0147058823529412 0.439972618260787 0.968717488861566 0.999842050055206 GO:0140658 ATP-dependent chromatin remodeler activity 2/623 158/18639 0.0126582278481013 0.378710608123209 0.970426949316022 0.999842050055206 GO:0140097 catalytic activity, acting on DNA 6/623 336/18639 0.0178571428571429 0.534252465030956 0.970443404814352 0.999842050055206 GO:0003689 DNA clamp loader activity 2/623 160/18639 0.0125 0.373976725521669 0.972088724910684 0.999842050055206 GO:0140713 histone chaperone activity 2/623 164/18639 0.0121951219512195 0.36485534197236 0.975146245146502 0.999842050055206 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/623 167/18639 0.0119760479041916 0.358301054392019 0.97722440391023 0.999842050055206 GO:0061630 ubiquitin protein ligase activity 6/623 353/18639 0.0169971671388102 0.508523592777341 0.979426801981274 0.999842050055206 GO:0003823 antigen binding 2/623 174/18639 0.0114942528735632 0.343886644157857 0.981440546063538 0.999842050055206 GO:0005096 GTPase activator activity 4/623 271/18639 0.014760147601476 0.441596133457322 0.98167445827826 0.999842050055206 GO:0061659 ubiquitin-like protein ligase activity 6/623 372/18639 0.0161290322580645 0.482550613576348 0.986432834269066 0.999842050055206 GO:0019783 ubiquitin-like protein peptidase activity 1/623 127/18639 0.0078740157480315 0.23557589009239 0.98686392455191 0.999842050055206 GO:0031490 chromatin DNA binding 1/623 128/18639 0.0078125 0.233735453451043 0.987306004014106 0.999842050055206 GO:0140597 protein carrier chaperone 2/623 188/18639 0.0106382978723404 0.318278064273761 0.987722249820017 0.999842050055206 GO:0016779 nucleotidyltransferase activity 1/623 136/18639 0.00735294117647059 0.219986309130394 0.990347702160443 0.999842050055206 GO:0008194 UDP-glycosyltransferase activity 1/623 145/18639 0.00689655172413793 0.206331986494714 0.992908639661163 0.999842050055206 GO:0015085 calcium ion transmembrane transporter activity 1/623 147/18639 0.00680272108843537 0.203524748583221 0.993378372612784 0.999842050055206 GO:0016887 ATP hydrolysis activity 6/623 417/18639 0.0143884892086331 0.430476806355878 0.995150864875032 0.999842050055206 GO:0005085 guanyl-nucleotide exchange factor activity 2/623 230/18639 0.00869565217391304 0.260157722102031 0.996534556046546 0.999842050055206 GO:0140030 modification-dependent protein binding 1/623 173/18639 0.00578034682080925 0.172937214114067 0.997285287525124 0.999842050055206 GO:0004842 ubiquitin-protein transferase activity 6/623 449/18639 0.0133630289532294 0.399796944878399 0.997740909409325 0.999842050055206 GO:0016755 aminoacyltransferase activity 7/623 496/18639 0.0141129032258065 0.422231786879304 0.997803900522484 0.999842050055206 GO:0141003 histone H2AX kinase activity 4/623 354/18639 0.0112994350282486 0.338058056968741 0.997829845003162 0.999842050055206 GO:0140996 histone H3 kinase activity 4/623 357/18639 0.0112044817927171 0.3352172329606 0.997997328833979 0.999842050055206 GO:0035173 histone kinase activity 4/623 360/18639 0.0111111111111111 0.332423756019262 0.9981522428584 0.999842050055206 GO:0019787 ubiquitin-like protein transferase activity 6/623 479/18639 0.0125260960334029 0.37475747025136 0.998919297642398 0.999842050055206 GO:0004518 nuclease activity 1/623 209/18639 0.00478468899521531 0.143148985845615 0.999211816351277 0.999842050055206 GO:0005216 monoatomic ion channel activity 5/623 448/18639 0.0111607142857143 0.333907790644348 0.999316884876018 0.999842050055206 GO:0106310 protein serine kinase activity 3/623 361/18639 0.00831024930747922 0.248627185942384 0.999608686097567 0.999842050055206 GO:0004674 protein serine/threonine kinase activity 4/623 433/18639 0.0092378752886836 0.276380028099155 0.999752967648639 0.999842050055206 GO:0030695 GTPase regulator activity 5/623 489/18639 0.0102249488752556 0.305911431919566 0.999771255165214 0.999842050055206 GO:0060589 nucleoside-triphosphatase regulator activity 5/623 490/18639 0.0102040816326531 0.305287122874832 0.999777358802548 0.999842050055206 GO:0140098 catalytic activity, acting on RNA 3/623 387/18639 0.00775193798449612 0.231923550711113 0.999818958126968 0.999842050055206 GO:0030371 translation repressor activity 2/623 329/18639 0.0060790273556231 0.181873179585006 0.999842050055206 0.999842050055206