category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	96/990	222/9376	4.0954408954409	RPS26/RPS10/RPL4/RPSA/RPL22/RPL27/RPL35/RPL36/RPL38/RPS5/RPL29/RPL35A/RPL10A/UBA52/RPLP0/RPL39/RPS13/RPL5/RPL37/RPS25/RPL6/RPL21/RPL37A/RPL24/RPS19/RPL14/RPS29/RPL7A/RPS16/RPL9/RPL12/RPS15/RPS11/RPS6/RPL18A/RPS27/RPL15/RPL34/RPS3/RPL3/RPL32/RPL27A/RPL23A/RPL23/RPS7/RPL26/RPS4X/RPLP2/RPS28/RPS3A/RPL19/RPL18/RPS27A/RPL8/RPL11/RPS8/RPL13A/RPS12/RPS24/RPL41/RPL28/RPS14/RPS18/RPS2/RPL10/RPLP1/RPL13/RPS20/RPL7/RPS9/RPS21/RPL31/RPL30/MRPS15/MRPL23/RPL17/FAU/RPL36A/RPS27L/MRPL52/MRPL11/MRPL51/RPL22L1/MRPS33/MRPL41/MRPS16/MRPL20/MRPS31/MRPL21/MRPL12/MRPS12/MRPL42/MRPL33/MRPL15/MRPS2/MRPS30	16.0368606553102
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	84/990	238/9376	3.34260249554367	ISG15/RPS26/RPS10/RPL4/RPSA/RPL22/RPL27/RPL35/RPL36/RPL38/RPS5/RPL29/RPL35A/RPL10A/UBA52/RPLP0/RPL39/RPS13/RPL5/RPL37/RPS25/RPL6/RPL21/RPL37A/RPL24/RPS19/RPL14/RPS29/RPL7A/RPS16/RPL9/RPL12/RPS15/RPS11/RPS6/RPL18A/RPS27/RPL15/RPL34/RPS3/RPL3/RPL32/RPL27A/RPL23A/RPL23/RPS7/RPL26/RPS4X/RPLP2/RPS28/RPS3A/RPL19/RPL18/RPS27A/RPL8/RPL11/RPS8/RPL13A/RPS12/RPS24/RPL41/RPL28/RPS14/RPS18/RPS2/RPL10/RPLP1/RPL13/RPS20/RPL7/RPS9/RPS21/RPL31/RPL30/RPL17/FAU/PIK3CB/RPL36A/RPS27L/EGFR/RPL22L1/F13A1/MX1/MASP1	12.5772968052129
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	54/990	158/9376	3.23682393555811	CCNE1/CCNB1/CDKN1C/PTTG1/YWHAE/WEE1/CDK7/YWHAB/CDC20/ANAPC11/CCNB2/YWHAZ/MAD2L1/CDK1/CCNA2/SKP2/AURKB/RBX1/MCM7/SFN/CDC6/MCM4/SKP1/CDT1/ORC6/CHEK1/YWHAG/PLK1/CDCA5/ANAPC15/SMC1A/TFDP2/TTK/DBF4/NDC80/PKMYT1/MCM3/ORC1/PCNA/CDC45/TICRR/GADD45A/BUB1/TP53/TFDP1/PRKDC/CDC25C/MCM5/BUB1B/ESCO2/ORC2/FBXO5/YWHAQ/DDX11	9.74244133634396
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	74/990	268/9376	2.61504598221016	TUBA1C/TXN/TUBA1B/CALM1/TUBB/UQCRH/PSMA7/UBA52/RPS27A/MT-CO3/MT-CO2/MT-CO1/GNAS/NDUFS5/NDUFA4/NDUFB2/COX5B/CALM3/COX5A/COX6C/TUBB4B/VDAC1/HSPA5/COX7B/SLC25A5/PSMA4/COX6B1/COX8C/SOD1/PSMB6/PSMB1/NDUFA6/UQCR10/COX7A2/PSMB3/SLC39A8/MT-ND6/UBE2L3/TUBB6/PARK7/COX7C/NDUFB11/CYCS/TXN2/COX8A/NDUFC1/SLC25A4/PSMB2/NDUFA11/COX4I1/PSMD14/COX6A1/PSMA3/PSMA1/PSMB5/SLC39A10/NDUFB4/MAOB/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/PSMD11/NDUFA1/TH/TP53/UQCRC1/NDUFA2/MAPT/NDUFS6/NDUFA3/PSMD4/XBP1	9.21651181605688
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	72/990	308/9376	2.21393152302243	TUBA1C/PPARG/TUBA1B/TUBB/UQCRH/PSMA7/MT-CO3/MT-CO2/MT-CO1/NDUFS5/NDUFA4/NDUFB2/COX5B/COX5A/GPX3/COX6C/TUBB4B/VDAC1/POLR2F/COX7B/SLC25A5/PSMA4/POLR2H/COX6B1/COX8C/SOD1/POLR2L/TGM2/PSMB6/PSMB1/NDUFA6/UQCR10/COX7A2/PSMB3/MT-ND6/TUBB6/CLTA/COX7C/NDUFB11/POLR2J/CYCS/COX8A/NDUFC1/SLC25A4/PSMB2/POLR2I/NDUFA11/COX4I1/PSMD14/COX6A1/PSMA3/PSMA1/PSMB5/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/TAF4B/HAP1/PSMD11/NDUFA1/SLC1A2/TP53/DNAH14/UQCRC1/NDUFA2/NDUFS6/NDUFA3/PSMD4/TBPL1	7.44285568447921
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	64/990	275/9376	2.20409182736455	TUBA1C/TUBA1B/TUBB/UQCRH/PSMA7/MT-CO3/MT-CO2/HSPA8/MT-CO1/NDUFS5/NDUFA4/NDUFB2/COX5B/COX5A/EGR1/COX6C/TUBB4B/VDAC1/HSPA5/COX7B/SLC25A5/PIK3CB/PSMA4/COX6B1/COX8C/SOD1/PSMB6/PSMB1/NDUFA6/UQCR10/COX7A2/PSMB3/RAC1/MT-ND6/TUBB6/COX7C/NDUFB11/CYCS/PPP3CA/COX8A/NDUFC1/SLC25A4/PSMB2/NDUFA11/COX4I1/PSMD14/COX6A1/PSMA3/STIP1/PSMA1/PSMB5/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/PSMD11/NDUFA1/UQCRC1/NDUFA2/NDUFS6/NDUFA3/PSMD4	6.96317331300948
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	78/990	368/9376	2.00737812911726	TUBA1C/TUBA1B/TUBB/UQCRH/PSMA7/PFN1/ACTB/MT-CO3/MT-CO2/HNRNPA1/MT-CO1/NDUFS5/NDUFA4/NDUFB2/CHCHD10/COX5B/COX5A/GPX3/COX6C/TUBB4B/VDAC1/HSPA5/COX7B/PSMA4/COX6B1/COX8C/ACTG1/SOD1/PSMB6/PSMB1/SRSF3/NDUFA6/UQCR10/COX7A2/PSMB3/RAC1/MT-ND6/NOS2/HNRNPA3/TUBB6/COX7C/NDUFB11/CYCS/PPP3CA/COX8A/NDUFC1/PSMB2/ALYREF/NDUFA11/COX4I1/PSMD14/HNRNPA2B1/COX6A1/PSMA3/PSMA1/PSMB5/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/NUP155/HAP1/PSMD11/NDUFA1/SLC1A2/TP53/DNAH14/CHMP2B/UQCRC1/NDUFA2/NUP37/VAPB/NDUFS6/NDUFA3/PSMD4/XBP1	6.77373254394339
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	40/990	138/9376	2.74513248426292	UQCRH/MT-CO3/MT-CO2/MT-CO1/NDUFS5/NDUFA4/NDUFB2/COX5B/COX5A/COX6C/PPA1/COX7B/ATP6V1C2/COX6B1/COX8C/NDUFA6/UQCR10/COX7A2/MT-ND6/COX7C/NDUFB11/ATP6V1B1/CYCS/COX8A/NDUFC1/NDUFA11/COX4I1/COX17/COX6A1/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/NDUFA1/UQCRC1/NDUFA2/NDUFS6/NDUFA3	7.09585567010845
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/990	157/9376	2.59388792382423	LEP/PPARG/UQCRH/MT-CO3/MT-CO2/MT-CO1/NDUFS5/NDUFA4/NDUFB2/COX5B/CDC42/COX5A/COX6C/COX7B/PIK3CB/COX6B1/COX8C/NDUFA6/UQCR10/COX7A2/RAC1/COX7C/NDUFB11/CYCS/COX8A/NDUFC1/NDUFA11/COX4I1/COX6A1/INSR/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/NDUFA1/UQCRC1/NDUFA2/CEBPA/NDUFS6/NDUFA3/XBP1	6.91976754299115
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	50/990	205/9376	2.30992855383099	SLC2A1/UQCRH/GAPDH/MT-CO3/MT-CO2/MT-CO1/PPP1CB/NDUFS5/NDUFA4/NDUFB2/COX5B/COX5A/COX6C/VDAC1/COX7B/SLC25A5/PIK3CB/COX6B1/PRKCZ/COX8C/NDUFA6/UQCR10/COX7A2/RAC1/MT-ND6/COX7C/NDUFB11/COX8A/NDUFC1/SLC25A4/NDUFA11/COX4I1/COX6A1/INSR/PDK3/NDUFB4/GYS1/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/NDUFA1/UQCRC1/NDUFA2/PPP1CA/PARP1/CPT2/NDUFS6/NDUFA3	6.51541373841735
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	77/990	388/9376	1.8794959908362	TUBA1C/TUBA1B/CALM1/TUBB/UQCRH/PSMA7/GAPDH/MT-CO3/MT-CO2/MT-CO1/CTNNB1/NDUFS5/NDUFA4/NDUFB2/WNT7A/COX5B/CALM3/COX5A/COX6C/TUBB4B/VDAC1/COX7B/SLC25A5/PIK3CB/PSMA4/COX6B1/COX8C/PSMB6/PSMB1/NDUFA6/UQCR10/COX7A2/PSMB3/SLC39A8/MT-ND6/NOS2/HSD17B10/APP/TUBB6/COX7C/NDUFB11/CYCS/PPP3CA/COX8A/WNT10B/NDUFC1/SLC25A4/PSMB2/NDUFA11/COX4I1/PSMD14/COX6A1/PSMA3/BACE2/CHRM5/PSMA1/PSMB5/WNT4/INSR/SLC39A10/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/PSMD11/NDUFA1/FRAT2/UQCRC1/NDUFA2/MAPT/WNT5A/NDUFS6/NDUFA3/PSMD4/XBP1	6.07916598472765
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	53/990	235/9376	2.13594670105308	PPARG/UQCRH/RPS6/ACTB/MT-CO3/MT-CO2/MT-CO1/GNAS/NDUFS5/NDUFA4/NDUFB2/COX5B/COX5A/COX6C/GRB2/COX7B/COX20/COX6B1/COX8C/ACTG1/NDUFA6/UQCR10/ACSL4/COX7A2/MT-ND6/COX7C/NDUFB11/KDM1A/COX8A/NDUFC1/SMARCA2/NDUFA11/COX4I1/COX17/COX6A1/NPR1/NDUFB4/ADCY1/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/SMARCC1/NDUFA1/COA4/UQCRC1/NDUFA2/ACSL5/CPT2/NPPB/NDUFS6/NDUFA3	6.05927743288534
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	16/990	36/9376	4.20920314253648	RPA3/SSBP1/MCM7/RNASEH2A/MCM4/RFC3/RNASEH2C/LIG1/FEN1/MCM3/PCNA/DNA2/POLE2/MCM5/POLA2/RPA2	6.6282797160842
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	50/990	227/9376	2.08605882614693	MGST3/UQCRH/MT-CO3/MT-CO2/MT-CO1/NDUFS5/NDUFA4/NDUFB2/MGST1/COX5B/COX5A/COX6C/VDAC1/GRB2/COX7B/SLC25A5/PIK3CB/COX6B1/COX8C/SOD1/NDUFA6/UQCR10/COX7A2/RAC1/MT-ND6/EGFR/COX7C/ACP1/NDUFB11/COX8A/NDUFC1/SLC25A4/NDUFA11/COX4I1/COX6A1/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/NDUFA1/GSTA3/GSTO2/UQCRC1/NDUFA2/GSTA4/NDUFS6/CBR1/NDUFA3	5.69121864482658
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	23/990	75/9376	2.90435016835017	PKM/ENO1/ALDOA/GAPDH/TPI1/PGK1/PFKP/TALDO1/CBS/IDH2/PGAM1/ARG2/TKT/IDH1/PRPS2/RPIA/SHMT1/ASNS/PSAT1/ASS1/RPE/CTH/IDH3G	5.68903262881115
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	39/990	170/9376	2.17269162210339	TUBA1C/CLDN7/CLDN4/EZR/TUBA1B/ACTB/ITGB1/ARPC1B/CLDN19/CDC42/ARPC3/CLDN10/ARPC2/CLDN6/VASP/PRKCZ/ACTG1/ARPC5/MYH9/RAC1/CLDN3/MARVELD2/TIAM1/ACTN1/MYL12B/F11R/TJP2/PARD6B/ARPC4/ACTR3/CRB3/RAB8B/CLDN5/CTTN/PCNA/TJP3/ARPC1A/HSPA4/ARPC5L	5.30149803007675
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	83/990	480/9376	1.6376430976431	TUBA1C/TUBA1B/CALM1/TUBB/UQCRH/PSMA7/UBA52/RPS27A/MT-CO3/MT-CO2/MT-CO1/CTNNB1/NDUFS5/NDUFA4/NDUFB2/WNT7A/COX5B/CALM3/COX5A/GPX3/COX6C/TUBB4B/VDAC1/HSPA5/COX7B/SLC25A5/PSMA4/COX6B1/COX8C/SOD1/PSMB6/PSMB1/NDUFA6/UQCR10/COX7A2/PSMB3/RAC1/MT-ND6/NOS2/HSD17B10/UBE2L3/APP/TUBB6/PARK7/COX7C/NDUFB11/CYCS/PPP3CA/COX8A/WNT10B/NDUFC1/SLC25A4/PSMB2/NDUFA11/COX4I1/PSMD14/COX6A1/PSMA3/CHRM5/PSMA1/PSMB5/WNT4/NDUFB4/UQCRQ/NDUFA12/NDUFB3/NDUFV2/NDUFB1/HAP1/PSMD11/NDUFA1/FRAT2/DNAH14/CHMP2B/UQCRC1/NDUFA2/VAPB/MAPT/WNT5A/NDUFS6/NDUFA3/PSMD4/XBP1	4.92750077131135
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/990	87/9376	2.61260884709161	TPM1/UQCRH/MT-CO3/MT-CO2/MT-CO1/TPM2/COX5B/COX5A/TPM3/COX6C/TPM4/COX7B/COX6B1/COX8C/UQCR10/COX7A2/MYL4/COX7C/COX8A/COX4I1/COX6A1/UQCRQ/ATP1A4/UQCRC1	5.19194387910281
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/990	78/9376	2.67122507122507	ACTB/ITGA5/CTNNB1/ITGB1/CDH1/ARPC1B/CDC42/ARPC3/ARPC2/PIK3CB/ACTG1/ARPC5/RAC1/CLTA/PXN/ARPC4/ACTR3/CTTN/DNM2/ARPC1A/WASF1/ARPC5L	5.09229176834963
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	23/990	85/9376	2.56266191325015	RRM2/AK5/TYMS/ADK/TK1/NME1/PNP/DTYMK/ADA/APRT/NME1-NME2/RRM1/UCK2/NME2/CTPS1/AK4/DUT/NTPCR/NUDT16/AK2/UPP1/HDDC2/NT5E	4.97243444814683
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	41/990	200/9376	1.94149494949495	TUBA1C/CLDN7/CLDN4/EZR/TUBA1B/TUBB/GAPDH/RPS3/ACTB/ITGB1/ARPC1B/CLDN19/CDC42/ARPC3/CLDN10/NCL/BAIAP2L1/ARPC2/TUBB4B/CLDN6/ACTG1/ARPC5/MYH9/RAC1/CYFIP2/CLDN3/TMED10/TUBB6/CYCS/TNFSF10/ARPC4/MYO1B/TMBIM6/ACTR3/PAK3/CLDN5/CTTN/PAK1/ARPC1A/WASF1/ARPC5L	4.62415194898918
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	18/990	59/9376	2.88936825885978	RRM2/MGST3/PRDX6/GSTP1/MGST1/GPX4/GPX3/SMS/SRM/GGCT/IDH2/IDH1/ODC1/RRM1/GSTA3/GSTO2/GSS/GSTA4	5.00184672863828
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	31/990	138/9376	2.12747767530376	CCNE1/CCNB1/CALM1/PTTG1/YWHAE/PPP1CB/YWHAB/CDC20/ANAPC11/CALM3/CCNB2/YWHAZ/AURKA/MAD2L1/CDK1/RBX1/SKP1/PPP3CA/YWHAG/PLK1/ANAPC15/SMC1A/PKMYT1/ADCY1/PGR/BUB1/IGF1/CDC25C/PPP1CA/FBXO5/YWHAQ	4.58441919302418
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/990	116/9376	2.12274468826193	GCSH/PKM/ENO1/ALDOA/GAPDH/TPI1/GLDC/PGK1/PFKP/ACAT2/TALDO1/PGP/IDH2/PGAM1/TKT/IDH1/PRPS2/RPIA/SHMT1/PCCA/HK2/MDH2/PSAT1/HK1/RPE/IDH3G	4.1805201091351
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/990	46/9376	2.88238910847607	PSMA7/POMP/PSMA4/PSMB6/PSMB1/PSMB3/PSMB2/PSMD14/PSMA3/PSMA1/PSMB5/PSMD11/PSME2/PSMD4	4.39717046039728
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/990	116/9376	2.04110066179032	CLDN7/CLDN4/EZR/ACTB/CTNNB1/ITGB1/CLDN19/CDH5/CDC42/CLDN10/PIK3CB/CLDN6/VASP/ACTG1/RAC1/CLDN3/ACTN1/PXN/MYL12B/F11R/CLDN5/CXCL12/PTK2B/VAV2/ESAM	3.87652001185234
NA	NA	hsa04518	Integrin signaling	30/990	154/9376	1.84494293585203	PGF/ACTB/ITGA5/CTNNB1/ITGB1/COL4A1/CDH1/CDC42/RAC3/FLT4/PIK3CB/COL4A2/ACTG1/LAMA4/RAC1/EGFR/ACTN1/COL6A3/PXN/FLNB/ITGB4/ITGA6/FERMT1/LAMC2/FLT1/RELN/IGF1/KDR/LAMA1/ICAM3	3.63246122704024
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	12/990	41/9376	2.77191426459719	GCSH/GLDC/ALAS2/CBS/PGAM1/ALDH7A1/GATM/SHMT1/GCAT/PSAT1/MAOB/CTH	3.90663897085767
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	40/990	232/9376	1.63288052943225	EZR/CFL1/PFN1/ACTB/ITGA5/PPP1CB/ITGB1/ARPC1B/CDC42/ARPC3/RAC3/ARPC2/PIK3CB/DIAPH3/ACTG1/ARPC5/MYH9/RAC1/CYFIP2/EGFR/TIAM1/ACTN1/PXN/MYL12B/ITGB4/ITGA6/ARPC4/ACTR3/CHRM5/PAK3/CXCL12/IQGAP3/PAK1/ARPC1A/WASF1/IQGAP1/DIAPH1/PPP1CA/VAV2/ARPC5L	3.35369393157574
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/990	203/9376	1.6795342588446	PGF/ACTB/ITGA5/CTNNB1/PPP1CB/ITGB1/COL4A1/CDC42/RAC3/FLT4/GRB2/PIK3CB/VASP/COL4A2/ACTG1/LAMA4/RAC1/EGFR/ACTN1/COL6A3/PXN/MYL12B/FLNB/ITGB4/ITGA6/PAK3/LAMC2/FLT1/RELN/IGF1/PAK1/KDR/LAMA1/DIAPH1/PPP1CA/VAV2	3.36302027286414
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/990	67/9376	2.2616613900196	PKM/ENO1/ALDOA/GAPDH/TPI1/LDHB/PGK1/PFKP/LDHA/PGAM1/ALDH7A1/HK2/PGM1/ALDH3B2/ALDH1B1/HK1	3.56085677194468
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/990	50/9376	2.46238383838384	SAT1/SMS/SRM/NOS2/ARG2/CKMT1A/ALDH7A1/CKMT1B/GATM/ODC1/MAOB/ALDH1B1/ALDH4A1	3.56225071130217
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	25/990	128/9376	1.84974747474747	RRM2/AK5/ADK/NME1/PNP/PAICS/ADA/PDE6H/PRPS2/ATIC/APRT/NME1-NME2/PGM1/RRM1/NPR1/ADCY1/NME2/AK4/PDE4D/PPAT/NTPCR/NUDT16/AK2/HDDC2/NT5E	3.32580485826775
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	17/990	75/9376	2.1466936026936	CCNE1/PERP/CCNB1/RRM2/CCNB2/CDK1/SFN/GTSE1/CYCS/CHEK1/RPRM/SIVA1/PPP1R13L/GADD45A/IGF1/TP53/TP53I3	3.42561858075955
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	11/990	39/9376	2.67122507122507	GCSH/GLDC/TYMS/CBS/ALDH7A1/MTHFD1L/ATIC/SHMT1/AHCY/DHFR/CTH	3.59326603875658
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/990	110/9376	1.89414141414141	SLC2A1/ENO1/ALDOA/GAPDH/RPS6/LDHB/PGK1/PFKP/LDHA/EGLN3/PIK3CB/RBX1/NOS2/EGFR/ANGPT4/HK2/INSR/FLT1/IGF1/PDK1/HK1/EIF4E2	3.24102373689553
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/990	71/9376	2.1342438469199	SLC2A1/SLC16A3/PKM/LDHB/PFKP/LDHA/PIK3CB/IDH2/PGAM1/EGFR/IDH1/SLC7A5/HK2/PDK1/TP53/HK1	3.29612159102396
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/990	59/9376	2.24728642355761	RRM2/TYMS/TK1/NME1/DTYMK/NME1-NME2/RRM1/UCK2/NME2/CTPS1/DUT/UPP1/HDDC2/NT5E	3.30202197908818
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/990	30/9376	2.84121212121212	ABCG2/FOLR1/TYMS/ATIC/GGH/SHMT1/SLC19A1/DHFR/FPGS	3.47038270873961
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/990	15/9376	3.78828282828283	AK5/ACP1/AK4/NTPCR/AK2/TPK1	3.71318970352483
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/990	54/9376	2.27998503554059	LDHB/SMS/LDHA/SRM/ADI1/CBS/DNMT1/AHCY/MDH2/PSAT1/GSS/DNMT3B/CTH	3.24095521180885
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/990	93/9376	1.93487563810144	ACTB/CTNNB1/CDH1/ARHGAP29/CDH5/CDC42/PTPRF/RAC3/TCF7L2/ACTG1/RAC1/EGFR/ACP1/ACTN1/MYL12B/SNAI1/INSR/WASF1/IQGAP1	3.11298442762257
NA	NA	hsa04517	IgSF CAM signaling	46/990	299/9376	1.45703185703186	TUBA1C/EZR/TUBA1B/TUBB/ACTB/ITGA5/CTNNB1/ITGB1/CDH1/ARPC1B/CDC42/ARPC3/PTPRF/ARPC2/TUBB4B/GRB2/PIK3CB/IL1RAP/ACTG1/ARPC5/MYH9/RAC1/APP/TUBB6/ACTN1/DYNLL1/PXN/MYL12B/F11R/PTPRS/TJP2/PARD6B/ARPC4/ACTR3/DYNLL2/PAK3/GRIP1/PAK1/KDR/ARPC1A/IQGAP1/ICAM3/CNTNAP2/VAV2/ARPC5L/ESAM	2.75954007975652
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/990	154/9376	1.66044864226682	RFK/AK5/GCH1/UGP2/NME1/ALAS2/MTHFD1L/CPOX/GGH/SHMT1/NME1-NME2/PSAT1/NME2/DHFR/CTPS1/AK4/ALDH1B1/VKORC1/UROS/HMBS/COQ2/GSS/RDH13/AK2/TPK1/FPGS/MMAB	2.8393090038281
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	40/990	253/9376	1.49734499141614	PFN1/UBA52/RPS27A/ACTB/ITGA5/BNIP3/ITGB1/ARPC1B/CDC42/ARPC3/ARPC2/CBX3/VDAC1/PIK3CB/ACTG1/RBX1/ARPC5/RAC1/EGFR/PLCD4/SKP1/CYCS/ACTN1/PXN/MYL12B/ARPC4/HK2/ACTR3/UBE2N/CTTN/FNBP1L/FOXO4/TP53/ARPC1A/WASF1/DIAPH1/U2AF1/HK1/ARPC5L/UBE2V2	2.75533861231416
NA	NA	hsa04519	Cadherin signaling	59/990	404/9376	1.38309830983098	KRT19/KRT7/DSP/KRT8/DSC2/KRT18/ACTB/YWHAE/KRT23/LIMA1/CTNNB1/PPP1CB/PKP3/YWHAB/CDH1/ARPC1B/CDH5/WNT7A/CDC42/DSG2/ARPC3/RAC3/FLT4/YWHAZ/ARPC2/TCF7L2/VASP/ACTG1/ARPC5/RAC1/CYFIP2/JUP/EGFR/KRT10/TEAD1/FAT2/ACTN1/WWTR1/WNT10B/YWHAG/ARPC4/MYO1B/ACTR3/WNT4/TMC4/DSC3/TMC5/KRT15/PTK2B/KDR/ARPC1A/WASF1/PPP1CA/FMN1/WNT5A/VAV2/ARPC5L/YWHAQ/KRT14	2.70446952814329
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/990	52/9376	2.18554778554779	CGA/CYP11A1/HSD3B1/GNAS/CYP19A1/LDLR/CYP2J2/HSD17B1/INSR/ADCY1/IGF1/ACOT4	2.94540764356219
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	39/990	248/9376	1.48934506353861	TUBA1C/TXN/TUBA1B/TUBB/PFN1/GAPDH/RPS3/ACTB/HSP90AB1/CTNNB1/ANXA2/ARPC1B/CDC42/ARPC3/ARPC2/TUBB4B/TCF7L2/PIK3CB/ACTG1/ARPC5/RAC1/CYFIP2/TUBB6/SKP1/CYCS/TXN2/DYNLL1/MYL12B/TNFSF10/ARPC4/ACTR3/DYNLL2/PAK3/PIK3C2G/DNM2/PAK1/ARPC1A/FBXO22/ARPC5L	2.68336062488665
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/990	142/9376	1.66737800540617	TXN/MGST3/CALM1/GSTP1/ACTB/HSP90AB1/CTNNB1/MGST1/SDC4/CDH5/CALM3/RAC3/CTSL/PIK3CB/PRKCZ/ACTG1/IL1R2/RAC1/TXN2/GSTA3/TP53/ASS1/KDR/GSTO2/GSTA4	2.75325814818679
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/990	23/9376	2.88238910847607	RPA3/SSBP1/RFC3/LIG1/PCNA/EXO1/RPA2	3.10544368936467
NA	NA	hsa03272	Virion - Hepatitis viruses	11/990	48/9376	2.17037037037037	CLDN7/CLDN4/CLDN19/CLDN10/LDLR/CLDN6/CLDN3/EGFR/EPCAM/HSPG2/CLDN5	2.79302919231645
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	36/990	233/9376	1.46328521264144	DSP/DSC2/TPM1/TNNI2/ENO1/ACTB/ITGA5/ITGB1/COL4A1/SDC4/TPM2/DSG2/CSRP1/TPM3/LMNB1/TPM4/DIAPH3/COL4A2/ACTG1/MYH9/LMNB2/JUP/MYL4/NID2/COL6A3/FHL2/HSPG2/ITGB4/ITGA6/DAG1/COL27A1/PDLIM2/ATP1A4/LAMA1/DIAPH1/INF2	2.46041205091945
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/990	31/9376	2.44405343760182	ALDOA/PFKP/TALDO1/TKT/PRPS2/RPIA/PGM1/RPE	2.76694333531614
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/990	31/9376	2.44405343760182	SEC61G/HSPA5/SPCS3/SRP14/SEC11C/SEC11A/SEC61B/SRP19	2.76694333531614
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/990	63/9376	1.95427288760622	CDK7/POLR2F/RPA3/POLR2H/RBX1/POLR2L/RFC3/POLR2J/POLR2I/LIG1/PCNA/POLE2/RPA2	2.61110216418298
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	26/990	157/9376	1.56839734928907	ACTB/YWHAE/BIRC5/CTNNB1/PPP1CB/ID1/YWHAB/CDH1/WNT7A/YWHAZ/TCF7L2/PRKCZ/ACTG1/TEAD1/RASSF6/WWTR1/WNT10B/YWHAG/BMP7/PARD6B/WNT4/DLG5/PPP1CA/GDF7/WNT5A/YWHAQ	2.4676625441115
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/990	98/9376	1.73951762523191	CFL1/ARPC1B/CDC42/ARPC3/ARPC2/PIK3CB/VASP/ARPC5/RAC1/ARPC4/ACTR3/MARCKSL1/DNM2/PAK1/ARPC1A/WASF1/VAV2/ARPC5L	2.52848388119134
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/990	204/9376	1.48560110913052	EZR/RPS6/ACTB/ITGA5/CTNNB1/PPP1CB/ITGB1/ERBB3/SDC4/WNT7A/CDC42/CTSL/GRB2/PIK3CB/ACTG1/RAC1/EGFR/TIAM1/PXN/WNT10B/HSPG2/WNT4/CTTN/IGF1/TP53/PAK1/KDR/IQGAP1/PPP1CA/EIF4B/WNT5A/VAV2	2.40928699938739
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/990	20/9376	2.84121212121212	SQLE/FDFT1/MSMO1/EBP/DHCR24/DHCR7	2.83204091270663
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/990	93/9376	1.73120451830129	CCNE1/CKS1B/CKS2/ITGB1/COL4A1/PIK3CB/COL4A2/SKP2/LAMA4/NOS2/CYCS/TRAF4/ITGA6/LAMC2/GADD45A/TP53/LAMA1	2.43479259284344
Cellular Processes	Cell motility	hsa04814	Motor proteins	30/990	194/9376	1.46454233052171	TUBA1C/TPM1/TNNI2/TUBA1B/TUBB/ACTB/TPM2/TPM3/TUBB4B/TPM4/KIF21A/ACTG1/MYH9/CENPE/MYL4/TUBB6/KIF2C/DYNLL1/MYL12B/KIF23/KIFC1/KIF11/KIF14/MYO1B/KIF4A/DYNLL2/KIF20B/DNAH14/KIF20A/KIF18A	2.24638050556994
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/990	28/9376	2.36767676767677	AKR1B1/GCH1/GGH/DHFR/TH/FPGS/CBR1	2.49016967498701
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/990	82/9376	1.73244641537324	RRM2/MGST3/GSTP1/MGST1/TK1/NME1/NME1-NME2/RRM1/UCK2/NME2/DUT/GSTA3/GSTO2/GSTA4/UPP1	2.28879689944112
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/990	54/9376	1.92921810699588	UBE2T/RPA3/FANCE/RAD51/FANCI/FANCD2/BRCA1/FANCB/BRCA2/RAD51C/RPA2	2.35280427751529
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/990	44/9376	1.93719008264463	HMGB1/RFC3/LIG1/FEN1/PCNA/POLE2/SMUG1/PARP1/APEX1	2.14088068453004
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/990	212/9376	1.38486754335811	PGF/EFNA1/CALM1/PFN1/ACTB/GNAS/CTNNB1/ID1/ITGB1/CDH1/CDC42/CALM3/RAC3/FLT4/PIK3CB/VASP/PRKCZ/ACTG1/RAC1/EGFR/TIAM1/ANGPT4/PARD6B/INSR/ADCY1/FLT1/IGF1/KDR/EFNA3/EFNA4/VAV2	1.94743281783907
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/990	31/9376	2.1385467579016	GCSH/GLDC/ACAT2/PGP/SHMT1/PCCA/MDH2	2.18156356384802
NA	NA	hsa04981	Folate transport and metabolism	7/990	31/9376	2.1385467579016	ABCG2/FOLR1/TYMS/SHMT1/SLC19A1/DHFR/FPGS	2.18156356384802
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	26/990	174/9376	1.41516312550795	PDIA6/CALR/HSPA8/HSP90AB1/SSR4/PDIA4/MAN1A2/SEC61G/SSR3/TUSC3/HSPA5/RBX1/ERP29/P4HB/EDEM2/DNAJA1/SKP1/SEC61B/RPN2/OSTC/TMEM258/SVIP/BCAP31/CANX/HYOU1/XBP1	1.89923230571064
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/990	89/9376	1.59618658495063	ITGA5/ITGB1/COL4A1/SDC4/HMMR/COL4A2/LAMA4/COL6A3/HSPG2/ITGB4/ITGA6/DAG1/LAMC2/RELN/LAMA1	1.94162469294685
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/990	32/9376	2.07171717171717	AKR1B1/PFKP/B4GALT1/UGP2/HK2/PGM1/HK1	2.08648165227601
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	22/990	144/9376	1.44691358024691	PSMA7/VDAC1/SLC25A5/PIK3CB/PSMA4/PSMB6/PSMB1/PSMB3/CYCS/SLC25A4/PSMB2/PSMD14/PSMA3/PSMA1/PSMB5/SLC1A6/RELN/PSMD11/NOP56/PSMD4/XBP1/TBPL1	1.85687515868275
NA	NA	hsa04382	Cornified envelope formation	31/990	217/9376	1.35295815295815	KRT19/KRT7/DSP/KRT8/CLDN7/KRT18/CLDN4/PRSS8/S100A11/KRT23/PKP3/COL4A1/CLDN19/DSG2/PADI1/CLDN10/CLDN6/S100A9/COL4A2/JUP/CLDN3/KRT10/PCSK6/ITGB4/ITGA6/TCHH/CLDN5/LAMC2/KRT15/S100A12/KRT14	1.80740243052891
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/990	61/9376	1.70783242258652	MT1G/MT1E/MT1H/MT1F/MT2A/MT1X/SLC6A19/ATP2B3/MT1A/MT1M/ATP1A4	1.90559123331116
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/990	34/9376	1.94985145573381	POLR2F/POLR2H/POLR2L/POLR2J/POLR2I/POLR1D/POLR3G	1.90634292151137
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/990	41/9376	1.84794284306479	RPA3/SSBP1/RAD51/XRCC2/BRCA1/BRCA2/RAD51C/RPA2	1.86950724533494
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/990	86/9376	1.54174301151045	DSP/DSC2/ACTB/ITGA5/CTNNB1/ITGB1/DSG2/TCF7L2/ACTG1/JUP/ITGB4/ITGA6/DAG1/LAMA1	1.73404551548178
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/990	110/9376	1.46365472910927	CCNB1/HSP90AB1/ANAPC11/CCNB2/AURKA/MAD2L1/PIK3CB/CDK1/CCNA2/PLK1/ANAPC15/PKMYT1/ADCY1/PGR/BUB1/IGF1/CDC25C	1.68062451755463
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/990	42/9376	1.8039442039442	SAT1/GPX4/ACSL4/CP/SLC39A8/TP53/GSS/ACSL5	1.79408271441632
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/990	35/9376	1.89414141414141	ALDOA/TPI1/AKR1B1/PFKP/PFKFB4/HK2/HK1	1.82082980314371
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	31/990	224/9376	1.31067821067821	HLA-G/CCNE1/SLC2A1/RANBP1/RAN/CALR/PTTG1/CDC20/ANAPC11/EGR1/CCNB2/IL2RB/VDAC1/MAD2L1/SLC25A5/PIK3CB/CCNA2/IL1R2/FDPS/PPP3CA/CHEK1/MSX2/SLC25A4/ANAPC15/IL15/ADCY1/CANX/TP53/BUB1B/NFYB/TBPL1	1.61697239290595
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/990	36/9376	1.84152637485971	PYGL/UGP2/HK2/PGM1/GYS1/GBE1/HK1	1.73808635766942
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/990	137/9376	1.38258497382585	TUBA1C/TUBA1B/ACTB/CTSV/BIRC5/LMNB1/CTSL/PIK3CB/ACTG1/LMNB2/CSF2RB/CYCS/TNFSF10/GZMB/CTSW/GADD45A/TP53/ENDOG/PARP1/AIFM1	1.54989228133296
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/990	51/9376	1.67130124777184	ACTB/GNAS/PDIA4/SEC61G/ATP6V1C2/ACTG1/ATP6V1B1/TJP2/SEC61B	1.65159640429727
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/990	105/9376	1.44315536315536	TPM1/ACTB/ITGA5/GNAS/ITGB1/TPM2/TPM3/TPM4/ACTG1/ITGB4/ITGA6/DAG1/ADCY1/IGF1/ADRB1/LAMA1	1.56896470906714
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/990	23/9376	2.05884936319719	HMGCS1/ACAT2/FDPS/IDI1/HMGCR	1.74682113178532
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/990	82/9376	1.50145355999015	HLA-G/CALR/HSPA8/HSP90AB1/CTSL/HSPA5/HSPA2/CANX/KLRC1/NFYB/HSPA4/TAP1/PSME2	1.56697517965774
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/990	138/9376	1.37256624213146	CALM1/RPS6/PPP1CB/PYGL/CALM3/PTPRF/CBLB/GRB2/PIK3CB/PRKCZ/FASN/SH2B2/HK2/INSR/GYS1/PPP1R3B/FLOT2/HK1/PPP1CA/EIF4E2	1.5148857210323
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/990	37/9376	1.79175539175539	ASNS/NIT2/RIMKLA/RIMKLB/PPAT/ASS1/ALDH4A1	1.65793504001586
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/990	37/9376	1.79175539175539	PPARG/CTNNB1/CDH1/TPM3/TCF7L2/GADD45A/TP53	1.65793504001586
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/990	75/9376	1.51531313131313	MGST3/GSTP1/TOP2A/BIRC5/MGST1/PIK3CB/CYCS/GSTA3/TP53/BRCA1/GSTO2/GSTA4	1.53944020738322
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/990	83/9376	1.48336375806255	PRDX1/PRDX5/SOD1/ACSL4/IDH2/NOS2/IDH1/SLC27A2/FAR2/MPV17L2/ECH1/ACSL5/ABCD1	1.51971086555853
Genetic Information Processing	Transcription	hsa03040	Spliceosome	32/990	243/9376	1.24717130149229	HNRNPA1/RBM8A/HSPA8/SNRPD2/SNRPG/SNRPD1/SNRPF/LSM4/SNRPB/LSM7/LSM3/HNRNPC/SNRPE/LSM5/SRSF3/HNRNPM/HNRNPA3/LSM2/SRSF2/ALYREF/THOC7/HNRNPK/SNRPA1/SNRPD3/TXNL4A/HNRNPU/TRA2A/THOC3/SRSF6/U2AF1/PPIH/MAGOH	1.34128250163757
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/990	184/9376	1.28678085199824	EFNA1/CFL1/ITGB1/CDC42/RAC3/PIK3CB/PRKCZ/RAC1/PPP3CA/MYL12B/BMP7/PARD6B/SEMA6A/SEMA7A/PAK3/WNT4/RGMA/CXCL12/PAK1/FES/GDF7/EFNA3/SEMA4C/EFNA4/WNT5A	1.34983243884276
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/990	63/9376	1.50328683662017	ACAT2/EZH2/AADAT/ALDH7A1/DHTKD1/HYKK/ALDH1B1/SUV39H1/SMYD2/SUV39H2	1.37710435387116
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/990	178/9376	1.2769492679605	NOTUM/CTNNB1/WNT7A/RAC3/TCF7L2/RBX1/SFRP1/CACYBP/APCDD1/RAC1/GPC4/SKP1/PPP3CA/WNT10B/RUVBL1/SFRP4/LGR4/WNT4/TLE1/RNF43/TP53/FRAT2/WNT5A/LGR5	1.28170868320757
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/990	56/9376	1.52207792207792	MAN1A2/TUSC3/B4GALT1/MAN2A1/RPN2/MGAT5/OSTC/MGAT5B/TMEM258	1.34631657226642
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/990	26/9376	1.82128982128982	SLC5A6/SLC19A1/AMN/PLB1/SLC52A3	1.4407980612351
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/990	138/9376	1.30393793002489	ACTB/ITGA5/ITGB1/ARPC1B/CDC42/ARPC3/RAC3/ARPC2/PIK3CB/ACTG1/ARPC5/RAC1/PXN/ARPC4/ACTR3/PTK2B/ARPC1A/VAV2/ARPC5L	1.23583722357849
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/990	106/9376	1.34019439679817	CCNE1/GSTP1/HSP90AB1/CTNNB1/FOLR1/GRB2/TCF7L2/PIK3CB/IL1R2/EGFR/SPINT1/ETV5/SLC19A1/IGF1/TP53	1.21022474426271
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/990	42/9376	1.57845117845118	ACAT2/AADAT/ALDH7A1/AOX1/MAOB/DHTKD1/ALDH1B1	1.29087224623493
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/990	13/9376	2.18554778554779	XRCC5/FEN1/PRKDC	1.46963347128655
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/990	149/9376	1.27123584841706	NDUFS5/NDUFA4/NDUFB2/NDUFA6/MT-ND6/GNG4/NDUFB11/GNG5/NDUFC1/NDUFA11/NDUFB4/ADCY1/NDUFA12/NDUFB3/NDUFV2/NDUFB1/NDUFA1/NDUFA2/NDUFS6/NDUFA3	1.14666291978088
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/990	28/9376	1.69119769119769	B4GALT1/ST3GAL6/ST8SIA1/B3GNT3/B3GNT5	1.25848414678073
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/990	160/9376	1.2430303030303	HLA-G/CLDN7/CLDN4/ITGB1/SDC4/CDH1/CLDN19/CDH5/CLDN10/PTPRF/CLDN6/CLDN3/F11R/PTPRS/ITGA6/CD274/CLDN5/ICAM3/CNTNAP2/PDCD1LG2/ESAM	1.06530752109172
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/990	36/9376	1.57845117845118	GALNT3/GALNT2/GALNT6/GALNT13/ST6GALNAC2/B3GNT3	1.19473154006778
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/990	76/9376	1.37076023391813	PPARG/FABP7/SCD/PLIN2/DBI/HMGCS1/SLC27A6/ACSL4/SLC27A2/ACSL5/CPT2	1.11502415530855
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/990	44/9376	1.50670339761249	MAN1A2/TUSC3/B4GALT1/MAN2A1/RPN2/OSTC/TMEM258	1.15749359369359
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	44/990	362/9376	1.15113566605279	CCNE1/PGF/EFNA1/RPS6/YWHAE/ITGA5/HSP90AB1/ITGB1/ERBB3/COL4A1/YWHAB/FLT4/IL2RB/YWHAZ/GRB2/PIK3CB/COL4A2/LAMA4/RAC1/EGFR/GNG4/ANGPT4/COL6A3/GNG5/YWHAG/ITGB4/ITGA6/INSR/GYS1/CDC37/LAMC2/FLT1/RELN/IGF1/TP53/BRCA1/KDR/LAMA1/EIF4E2/EIF4B/EFNA3/EFNA4/YWHAQ/PKN3	1.00760027916353
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	22/990	170/9376	1.22562091503268	MGST3/GSTP1/ACTB/CTNNB1/MGST1/WNT7A/GRB2/TCF7L2/PIK3CB/ACTG1/EGFR/WNT10B/SMARCA2/WNT4/GADD45A/SMARCC1/GSTA3/TP53/FRAT2/GSTO2/GSTA4/WNT5A	1.01998582921949
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/990	37/9376	1.53579033579034	UGP2/CMAS/GNPNAT1/HK2/PGM1/HK1	1.1219444553945
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/990	103/9376	1.28728057271747	PRDX1/GNAS/COL4A1/PIK3CB/COL4A2/LAMA4/IL1R2/NOS2/ARG2/ACTN1/ADCY1/SERPINB9/LAMC2/LAMA1	1.00725758589386
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/990	78/9376	1.33561253561254	ENO1/LSM4/LSM7/HSPD1/PFKP/LSM3/LSM5/LSM2/EXOSC5/NUDT16/EXOSC8	1.02262524771835
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/990	22/9376	1.72194674012856	ALDH7A1/MAOB/ALDH3B2/ALDH1B1	1.16477924606856
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/990	30/9376	1.57845117845118	IDH2/IDH1/MDH2/ACLY/IDH3G	1.09028554853607
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/990	46/9376	1.44119455423803	ALAS2/CP/CPOX/UROS/HMBS/HCCS/MMAB	1.03060926800315
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/990	156/9376	1.21419321419321	CLDN7/CLDN4/YWHAE/CTNNB1/YWHAB/CLDN19/CLDN10/YWHAZ/GRB2/LDLR/PIK3CB/CLDN6/CLDN3/EGFR/CYCS/YWHAG/CLDN5/TP53/MX1/YWHAQ	0.926890333713884
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/990	157/9376	1.20645949945313	HLA-G/CCNE1/CCNB1/CALM1/PPP1CB/CALM3/CCNB2/VDAC1/SLC25A5/PIK3CB/CDK1/CCNA2/MYBL2/PPP3CA/CHEK1/SLC25A4/GADD45A/FOXM1/TP53/PPP1CA	0.896331368036337
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/990	47/9376	1.41053084031807	PKM/LDHB/LDHA/ACAT2/ALDH7A1/MDH2/ALDH1B1	0.969399914517991
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/990	16/9376	1.77575757575758	MIF/MAOB/ALDH3B2	1.06702328987846
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/990	48/9376	1.38114478114478	HMGCS1/ACAT2/HSD17B10/ALDH7A1/PCCA/AOX1/ALDH1B1	0.909582579315945
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/990	142/9376	1.20051216389245	UBE2C/UBA52/RPS27A/UBE2S/CDC20/ANAPC11/CBLB/SKP2/RBX1/UBE2L3/SKP1/UBE2F/ANAPC15/UBE2N/UBE2Q2/BRCA1/HERC3/UBE2A	0.827209983810374
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/990	99/9376	1.24362820120396	TPM1/ACTB/ITGA5/ITGB1/TPM2/TPM3/TPM4/ACTG1/ITGB4/ITGA6/DAG1/IGF1/LAMA1	0.837273188218444
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/990	57/9376	1.32922204501152	SCD/ACAT2/ACSL4/FASN/TECR/ELOVL6/ACSL5/CPT2	0.856579125707153
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/990	205/9376	1.1549642769155	HLA-G/CCNE1/PKM/RANBP1/YWHAE/YWHAB/CDC20/CDC42/YWHAZ/GRB2/PIK3CB/CDK1/CCNA2/SKP2/RAC1/CHEK1/ACTN1/PXN/DDX3X/YWHAG/HNRNPK/GTF2A2/TP53/YWHAQ/TBPL1	0.770772097322647
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	26/990	214/9376	1.15064665345039	HLA-G/CCNB1/CFL1/CALM1/CALR/WEE1/CALM3/CCNB2/AP1M2/RAC3/PIK3CB/CDK1/RBX1/RAC1/GNG4/SKP1/CYCS/PPP3CA/CHEK1/GNG5/PXN/PAK3/PTK2B/PAK1/CDC25C/TAP1	0.765944034197211
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/990	33/9376	1.4349556167738	IDH2/AADAT/IDH1/DHTKD1/IDH3G	0.859972463830502
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/990	76/9376	1.2461456671983	EZR/CALM1/ACTB/CA2/GNAS/CALM3/GAST/ACTG1/ADCY1/ATP1A4	0.740258365224922
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/990	155/9376	1.16092538286087	HLA-G/TUBA1C/TUBA1B/TUBB/CALR/ACTB/ITGA5/ITGB1/SEC61G/CTSL/TUBB4B/ATP6V1C2/ACTG1/RAC1/TUBB6/ATP6V1B1/SEC61B/CANX/TAP1	0.694108232786088
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/990	59/9376	1.28416367060435	CTNNB1/CDH1/GRB2/TCF7L2/PIK3CB/EGFR/GADD45A/TP53	0.752284854763028
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/990	77/9376	1.22996195723468	RALBP1/CDC42/RAC3/PIK3CB/RAC1/EGFR/RAD51/GADD45A/TP53/BRCA2	0.696159960840124
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/990	18/9376	1.57845117845118	ACSL4/FASN/ACSL5	0.843989898635398
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/990	18/9376	1.57845117845118	PRDX1/CD320/MMAB	0.843989898635398
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/990	148/9376	1.15184275184275	CTNNB1/WNT7A/FLT4/GRB2/TCF7L2/PIK3CB/HEY1/EGFR/WNT10B/WNT4/PGR/GADD45A/IGF1/TP53/BRCA1/FRAT2/BRCA2/WNT5A	0.639730323714509
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/990	43/9376	1.3214940098661	ACAT2/ACSL4/ALDH7A1/ALDH1B1/ACSL5/CPT2	0.72597603878703
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	23/990	193/9376	1.12863348511017	CDC42/RAC3/CCL4/CCR7/GRB2/PIK3CB/CCL3L1/PRKCZ/RAC1/GNG4/CCL21/TIAM1/GNG5/PXN/CXCR6/CXCL13/CCL4L2/ADCY1/CXCL12/PTK2B/PAK1/CCR1/VAV2	0.620392023106114
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/990	158/9376	1.13888249584452	RPS6/WNT7A/GRB2/ATP6V1C2/PIK3CB/SKP2/ATP6V1B1/WNT10B/SLC7A5/WNT4/INSR/SLC38A9/IGF1/LAMTOR2/GRB10/EIF4E2/EIF4B/CAB39L/WNT5A	0.60489989708228
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/990	87/9376	1.19744572158365	BIRC5/CTNNB1/RAC3/GRB2/TCF7L2/PIK3CB/RAC1/EGFR/CYCS/GADD45A/TP53	0.635694829208047
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/990	27/9376	1.40306771417883	SCD/TECR/ELOVL6/ACOT4	0.720614706551513
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/990	70/9376	1.21766233766234	SLC2A1/CDC42/GRB2/EGLN3/PIK3CB/RBX1/RAC1/PAK3/PAK1	0.628024507333422
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/990	70/9376	1.21766233766234	HLA-G/ACTB/CD55/RAC3/ACTG1/RAC1/CYCS/DAG1/LAMA1	0.628024507333422
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/990	44/9376	1.29146005509642	CDK7/TAF5L/TAF10/TAF4B/GTF2A2/TBPL1	0.665800048275363
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/990	44/9376	1.29146005509642	GNAS/RAB11A/ARHGDIB/DYNLL1/DYNLL2/NSF	0.665800048275363
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/990	19/9376	1.49537480063796	GCSH/GLDC/DHTKD1	0.742622669981649
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/990	333/9376	1.08074134740801	HLA-G/CCNE1/ISG15/PKM/ITGA5/GNAS/CTNNB1/ITGB1/COL4A1/WNT7A/CDC42/GRB2/TCF7L2/ATP6V1C2/PIK3CB/CCNA2/PRKCZ/COL4A2/LAMA4/HEY1/EGFR/ATP6V1B1/COL6A3/PXN/WNT10B/ITGB4/ITGA6/PARD6B/CRB3/WNT4/LAMC2/RELN/BCAP31/TP53/LAMA1/MX1/WNT5A/TBPL1	0.515451313221584
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/990	36/9376	1.31537598204265	DCXR/AKR1B1/UGP2/RPE/FGGY	0.651376722466133
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/990	89/9376	1.1705368289638	TUBA1C/TUBA1B/TUBB/GNAS/TUBB4B/GRB2/CDK1/EGFR/TUBB6/ADCY1/ADRB1	0.555394110721861
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/990	63/9376	1.20262946929614	CTNNB1/WNT7A/TCF7L2/WNT10B/WNT4/GADD45A/TP53/WNT5A	0.554439146996615
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/990	37/9376	1.27982527982528	MIF/AOX1/MAOB/ALDH3B2/TH	0.585953870773138
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/990	37/9376	1.27982527982528	HBA2/HBA1/HBB/LAMA4/THOP1	0.585953870773138
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/990	73/9376	1.16762141967621	MGST3/GSTP1/MGST1/AOX1/MAOB/ALDH3B2/GSTA3/GSTO2/GSTA4	0.493975307961058
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/990	12/9376	1.57845117845118	VKORC1/COQ2	0.688894055395472
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/990	29/9376	1.3063044235458	TEAD1/RASSF6/WWTR1/PAK1	0.567599432878265
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/990	38/9376	1.2461456671983	UGP2/GNPNAT1/HK2/PGM1/HK1	0.522375578904279
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/990	38/9376	1.2461456671983	PIK3CB/SFN/INSR/ATP1A4/IGF1	0.522375578904279
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	27/990	238/9376	1.07440794499618	PGF/EFNA1/RALBP1/CALM1/CDC42/CALM3/RAC3/FLT4/PLA2G10/GRB2/PIK3CB/RAC1/EGFR/GNG4/TIAM1/ANGPT4/GNG5/RASGRF2/PAK3/INSR/FLT1/FOXO4/IGF1/PAK1/KDR/EFNA3/EFNA4	0.39949193713538
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/990	47/9376	1.20902643455835	PKM/PIK3CB/PRKCZ/HK2/INSR/HK1	0.49358096370024
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/990	93/9376	1.12019115890084	CGA/CALM1/GNAS/CDC42/CALM3/EGR1/GRB2/EGFR/ADCY1/PTK2B/MAP3K4	0.400217088506069
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/990	75/9376	1.13648484848485	CGA/GNAS/PDIA4/GPX3/HSPA5/ADCY1/ATP1A4/LRP2/CANX	0.407733183357418
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/990	139/9376	1.09015333187995	KRT19/KRT18/CALM1/HSPA8/KRT23/HSP90AB1/GNAS/CALM3/GRB2/PIK3CB/EGFR/KRT10/ADCY1/PGR/KRT15/KRT14	0.367916713168806
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	28/990	250/9376	1.06071919191919	HLA-G/HSPA8/ARPC1B/FOLR1/RAB11A/CDC42/ARPC3/IL2RB/ARPC2/CBLB/LDLR/PRKCZ/ARPC5/EGFR/CHMP4C/CLTA/PARD6B/ARPC4/ACTR3/SNX3/CHMP2A/RAB11FIP4/DNM2/ARPC1A/CHMP2B/ARF3/ARPC5L/PSD4	0.334334783238843
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/990	68/9376	1.11420083184789	GRB2/TCF7L2/PIK3CB/CCNA2/JUP/ZBTB16/CEBPA/PIM2	0.324729200192226
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/990	59/9376	1.12364321177881	CGA/GNAS/PIK3CB/INSR/NPR1/ADCY1/ADRB1	0.327328667375502
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/990	133/9376	1.06812485759854	CCNB1/BNIP3/CCNB2/GRB2/PIK3CB/SKP2/PLK2/EGFR/PLK1/TNFSF10/INSR/HOMER1/GADD45A/FOXO4/IGF1	0.271863408703792
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/990	227/9376	1.04302941307347	HLA-G/CALM1/CALR/GNAS/CTNNB1/CALM3/RAC3/CCL4/GRB2/PIK3CB/CCL3L1/RAC1/EGFR/GNG4/CYCS/PPP3CA/GNG5/PXN/CCL4L2/ADCY1/CXCL12/TP53/PTK2B/CCR1/TAP1	0.225484837528058
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/990	14/9376	1.35295815295815	B3GNT7/B4GALT1	0.454076183959282
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/990	23/9376	1.23530961791831	NOS2/ARG2/ASS1	0.388198574205961
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/990	69/9376	1.09805299370517	CALM1/GNAS/PPP1CB/CALM3/PPP3CA/MAOB/TH/PPP1CA	0.280870645749105
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/990	134/9376	1.06015377657169	CALM1/RAMP1/GNAS/PPP1CB/CALM3/PLA2G10/MYH9/ADM/PRKCH/NPR1/ADCY1/KCNMB1/PPP1CA/NPPB/CALCRL	0.24096730580435
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/990	60/9376	1.10491582491583	CDC42/RAC3/PIK3CB/RAC1/PPP3CA/PXN/KDR	0.280109405255742
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/990	79/9376	1.0789413118527	MGST3/GSTP1/MGST1/ALDH3B2/GSTA3/GSTO2/GSTA4/CYP2S1/CBR1	0.242087450013436
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/990	79/9376	1.0789413118527	ATP6V1C2/CLTA/ATP6V1B1/SLC6A11/SLC1A6/SLC6A4/SLC1A2/DNM2/NSF	0.242087450013436
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/990	107/9376	1.06213537241575	SLC2A1/PKM/CALM1/LDHB/GNAS/PYGL/CALM3/PFKP/LDHA/PGAM1/PPP3CA/GYS1	0.22209570493976
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/990	98/9376	1.06303854875283	CALM1/CALM3/PIK3CB/PLCD4/IMPA2/INPP4B/PIK3C2G/SYNJ1/CDS1/DGKZ/SYNJ2	0.215535031183674
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/990	117/9376	1.05230078563412	ACTB/MORF4L2/CDK2AP2/ACTG1/MBD2/ACTR6/SMARCA2/RUVBL1/GATAD2A/SMARCC1/BAZ1A/CECR2/VPS72	0.195589216934828
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/990	108/9376	1.05230078563412	RAN/RBM8A/KPNA2/ALYREF/THOC7/NUP155/RANGAP1/THOC3/KPNB1/NUP37/UPF3B/MAGOH	0.187824778045817
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/990	99/9376	1.05230078563412	CALM1/GNAS/PPP1CB/CALM3/PIK3CB/IL1RAP/CYP2J2/PRKCH/ADCY1/IGF1/PPP1CA	0.179741283307134
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	12/990	109/9376	1.0426466499861	SLC2A1/PPP1CB/PYGL/PTPRF/PIK3CB/PRKCZ/SLC27A6/SLC27A2/INSR/GYS1/PPP1R3B/PPP1CA	0.153870156576634
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/990	166/9376	1.02694414019715	CALM1/PPP1CB/CALM3/VDAC1/SLC25A5/VASP/ADRA2C/ATP2B3/PPP3CA/SLC25A4/INSR/NPR1/ADCY1/ATP1A4/KCNMB1/ADRB1/PPP1CA/NPPB	0.120341207522305
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/990	100/9376	1.04177777777778	CCL4/IL2RB/CCR7/CCL3L1/CCL21/TNFSF10/CXCL13/CCL4L2/CXCL12/IL20RA/CCR1	0.144308121028249
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/990	53/9376	1.07215551743854	GNAS/RAB11A/CLTA/ATP2B3/ATP1A4/DNM2	0.180990360296401
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/990	63/9376	1.05230078563412	GPX4/PLA2G10/HPGD/CYP2J2/PTGES3/PLB1/CBR1	0.143106543559342
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/990	45/9376	1.05230078563412	ABCA7/ABCG2/DEFB1/TAP1/ABCD1	0.12083039112615
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/990	122/9376	1.00917370425567	LEP/PPARG/SCD/PFKP/PIK3CB/CCNA2/FASN/PFKFB4/HMGCR/INSR/GYS1/IGF1/CAB39L	0.0350417437427857
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/990	122/9376	1.00917370425567	DIO2/SLC2A1/ACTB/CTNNB1/PFKP/PIK3CB/ACTG1/PLCD4/WNT4/MED12L/ATP1A4/TP53/THRB	0.0350417437427857
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/990	17/9376	1.11420083184789	MYH9/DAG1	0.161921609054991
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/990	201/9376	0.989476858133575	PPARG/MYCN/IL2RB/HPGD/CCNA2/IL1R2/HMGA2/JUP/ETV4/SPINT1/ETV5/GZMB/FLT1/WT1/ZBTB16/GADD45A/IGF1/TP53/ASPSCR1/SIX4/CEBPA	-0.0518162791869512
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/990	76/9376	0.996916533758639	CALM1/CALM3/GRB2/PIK3CB/EGFR/GADD45A/IGF1/TP53	-0.00927321494234234
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/990	28/9376	1.01471861471861	TECR/ELOVL6/ACOT4	0.026798618574454
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/990	28/9376	1.01471861471861	CA2/ATP6V1C2/ATP6V1B1	0.026798618574454
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/990	78/9376	0.971354571354571	TPI1/PIK3CB/PLCD4/IMPA2/INPP4B/PIK3C2G/SYNJ1/SYNJ2	-0.0872838033629035
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/990	98/9376	0.966398680684395	CYP11A1/CALM1/HSD3B1/GNAS/CALM3/LDLR/ATP2B3/NPR1/ADCY1/ATP1A4	-0.114886233103135
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/990	49/9376	0.966398680684395	B4GALT1/GALNT3/GALNT2/GALNT6/GALNT13	-0.0810231619951545
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/990	70/9376	0.947070707070707	MGST3/GSTP1/MGST1/GSTA3/GSTO2/GSTA4/CBR1	-0.152717707033876
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/990	80/9376	0.947070707070707	RPS6/ERBB3/GRB2/PIK3CB/EGFR/IGF1/KDR/EIF4E2	-0.163349885662029
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/990	50/9376	0.947070707070707	HBA2/HBA1/HBB/GYPB/GYPA	-0.128931547543953
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/990	90/9376	0.947070707070707	SLC2A1/CA2/ABCG2/GNAS/LDLR/HMGCR/ADCY1/ATP1A4/KCNN2	-0.173351982969434
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/990	30/9376	0.947070707070707	PLA2G10/CYP2J2/PLB1	-0.0997630315656986
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/990	150/9376	0.947070707070707	CCNE1/CTNNB1/CDH1/WNT7A/GRB2/TCF7L2/PIK3CB/JUP/EGFR/WNT10B/WNT4/GADD45A/TP53/FRAT2/WNT5A	-0.224522982816064
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/990	71/9376	0.933731683027458	CDC42/ATP6V1C2/RAC1/EGFR/ATP6V1B1/F11R/PAK1	-0.19257625330494
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/990	101/9376	0.937693769376938	CALM1/GNAS/CTNNB1/WNT7A/CALM3/TCF7L2/WNT10B/WNT4/ADCY1/WNT5A	-0.216302237772601
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/990	51/9376	0.928500693206576	PLA2G10/GDPD3/PAFAH1B3/GDPD1/PLB1	-0.175909099531278
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/990	20/9376	0.947070707070707	UGP2/CMAS	-0.0814126310214107
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/990	31/9376	0.916520039100684	ALDH7A1/ALDH3B2/ALDH1B1	-0.159955522024458
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/990	62/9376	0.916520039100684	HSPA8/PIK3CB/SOD1/INSR/ADCY1/IGF1	-0.226587407984115
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/990	300/9376	0.947070707070707	PGF/EFNA1/STMN1/HSPA8/ERBB3/CDC42/RAC3/FLT4/GRB2/IL1RAP/RAC1/EGFR/PPP3CA/ANGPT4/RASGRF2/DUSP5/DUSP9/INSR/FLT1/GADD45A/IGF1/TP53/DUSP4/PAK1/KDR/EFNA3/MAPT/EFNA4/MAP3K4/MAP3K13	-0.320136566375556
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/990	52/9376	0.910644910644911	VDAC1/LDLR/LIPG/LRP2/VAPB	-0.221996250497871
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/990	83/9376	0.912839235730802	CCL4/POLR2F/POLR2H/POLR2L/CCL4L2/POLR1D/POLR3G/G3BP1	-0.27403618558664
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/990	154/9376	0.922471467926013	TPM1/CALM1/GNAS/PPP1CB/TPM2/CALM3/TPM3/TPM4/MYL4/ATP2B3/CREM/ADCY1/ATP1A4/ADRB1/PPP1CA	-0.33329988902046
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/990	32/9376	0.887878787878788	LDHB/LDHA/PCCA	-0.218284131387971
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/990	10/9376	0.947070707070707	ETHE1	-0.0575366831332924
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/990	216/9376	0.920763187429854	PPARG/CALM1/HSPA8/HSP90AB1/CDC42/CALM3/HSPD1/HSPA5/LDLR/PIK3CB/CCL3L1/RAC1/CYCS/PPP3CA/CYP2J2/TNFSF10/HSPA2/TP53/HSPA4/VAV2/XBP1	-0.404792019917657
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/990	65/9376	0.874219114219114	AKR1B1/LIPG/ALDH7A1/ALDH1B1/AGPAT5/DGKZ	-0.349622175039096
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/990	34/9376	0.835650623885918	RBX1/RORB/SKP1	-0.329847649249372
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/990	23/9376	0.823539745278876	B4GALT1/MGAT5B	-0.291112704583716
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/990	23/9376	0.823539745278876	CA2/ATP1A4	-0.291112704583716
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/990	67/9376	0.84812302125735	CALM1/PPP1CB/CALM3/PPP3CA/ADCY1/PPP1CA	-0.428650803247505
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/990	99/9376	0.860973370064279	RAC3/GRB2/PIK3CB/RAC1/LYPLA1/EGFR/SLC44A2/WASF1/DGKZ	-0.477790621604176
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/990	130/9376	0.874219114219114	GNAS/COL4A1/GRB2/PIK3CB/PRKCZ/COL4A2/NOS2/EGFR/GNG4/GNG5/RLN2/ADCY1	-0.496175352476558
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/990	89/9376	0.851299511973669	SLC38A1/GNG4/GNG5/SLC6A11/ADCY1/HAP1/PLCL1/NSF	-0.484278825946881
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/990	24/9376	0.789225589225589	HS6ST1/HS6ST2	-0.355219715526653
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/990	69/9376	0.823539745278876	CALM1/GNAS/CALM3/PPP3CA/NPR1/ADRB1	-0.505466521925906
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/990	101/9376	0.843924392439244	COL4A1/CDC42/EGR1/PIK3CB/PRKCZ/COL4A2/RAC1/PLCD4/DIAPH1	-0.541831897701318
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/990	133/9376	0.854499886078833	HLA-G/RAC3/GRB2/PIK3CB/RAC1/PPP3CA/TNFSF10/GZMB/KLRC1/PTK2B/PAK1/VAV2	-0.580642049492447
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/990	48/9376	0.789225589225589	PIK3CB/HK2/ATP1A4/HK1	-0.503002380434436
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/990	26/9376	0.728515928515929	PLA2G10/PLB1	-0.476267589967402
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/990	38/9376	0.747687400318979	PNP/AOX1/NT5E	-0.535463174401665
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/990	38/9376	0.747687400318979	ADA/BLNK/TAP1	-0.535463174401665
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/990	115/9376	0.823539745278876	GCM1/GATA3/NACA/GNAS/MMP15/EGR1/EGFR/ADCY1/WNK2/PDE4D	-0.654173106985908
Organismal Systems	Immune system	hsa04611	Platelet activation	11/990	126/9376	0.826807760141093	ACTB/GNAS/PPP1CB/ITGB1/PIK3CB/VASP/PRKCZ/ACTG1/MYL12B/ADCY1/PPP1CA	-0.672463383694399
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/990	27/9376	0.701533857089413	HMGCS1/ACAT2	-0.533605358164838
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/990	116/9376	0.816440264716127	GNAS/SLC38A1/GNG4/PPP3CA/GNG5/SLC1A6/ADCY1/HOMER1/SHANK2/SLC1A2	-0.683481447389155
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/990	73/9376	0.778414279784143	CDH1/PIK3CB/EGFR/GADD45A/IGF1/TP53	-0.653006486848967
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/990	15/9376	0.631380471380471	ST8SIA1	-0.490895049922593
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/990	86/9376	0.770871505755227	ERBB3/CBLB/GRB2/PIK3CB/EGFR/PAK3/PAK1	-0.7334090693786
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/990	41/9376	0.692978566149298	CDH1/EGFR/TP53	-0.676907411568481
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/990	29/9376	0.653152211772902	CALM1/CALM3	-0.642728582283576
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/990	120/9376	0.789225589225589	CALM1/YWHAE/CDC42/CALM3/GRB2/PIK3CB/RAC1/SH2B2/ARHGDIB/TP53	-0.798403882916683
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/990	163/9376	0.813434963128215	CCNE1/BIRC5/YWHAB/YWHAZ/GRB2/PIK3CB/CCNA2/CYCS/DDX3X/HSPG2/PCNA/TP53/PTK2B/YWHAQ	-0.825561309746363
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/990	65/9376	0.728515928515929	CYP11A1/HSD3B1/GNAS/LDLR/ADCY1	-0.754620632311961
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/990	65/9376	0.728515928515929	CGA/KISS1/KISS1R/PIK3CB/KCNN2	-0.754620632311961
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/990	16/9376	0.591919191919192	ST8SIA1	-0.561298709779812
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/990	99/9376	0.765309662279359	KRT19/KRT18/KRT23/KRT10/DEFB1/KRT15/KRT14/MASP1	-0.806556574059831
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/990	110/9376	0.774876033057851	ID3/ID1/RBX1/SKP1/GREM2/BMP7/RGMA/TFDP1/GDF7	-0.81601423339082
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/990	88/9376	0.753351698806244	TFPI/PROCR/CD55/SERPINB2/F5/F13A1/MASP1	-0.798700888860529
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/990	217/9376	0.829232416329191	MGST3/BIRC5/HSP90AB1/GNAS/MGST1/KLF5/GRB2/PIK3CB/KPNA2/CDC6/EGFR/PTGES3/ADCY1/PGR/KPNB1/GSTA3/ADRB1/GSTO2/GSTA4	-0.874454218426182
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/990	66/9376	0.717477808386899	CYP11A1/HSD3B1/CYP19A1/HSD17B1/STS	-0.791362561277816
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/990	144/9376	0.789225589225589	ID3/CTNNB1/DLX5/ID1/WNT7A/GRB2/PIK3CB/WNT10B/DUSP9/WNT4/IGF1/WNT5A	-0.875743733803669
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/990	78/9376	0.728515928515929	CFL1/CALM1/ITGA5/ITGB1/CALM3/NOS2	-0.827223170750408
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/990	155/9376	0.794317367220593	CCNE1/CYP11A1/HSD3B1/GNAS/CTNNB1/WNT7A/TCF7L2/LDLR/EGFR/WNT10B/WNT4/ADCY1/WNT5A	-0.887156557997673
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/990	112/9376	0.761038961038961	HSPA8/ITGB1/LDLR/LAMA4/NOS2/CYCS/ITGA6/LAMC2/LAMA1	-0.874103063740187
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/990	17/9376	0.557100415923945	CTH	-0.62797277517997
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/990	17/9376	0.557100415923945	CA2	-0.62797277517997
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/990	90/9376	0.736610549943883	PPARG/PIK3CB/INSR/ADCY1/IGF1/TP53/EIF4E2	-0.862642989042978
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/990	31/9376	0.611013359400456	ALDH7A1/ALDH1B1	-0.745335293492577
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/990	56/9376	0.676479076479076	HSPA8/BNIP3/HSPD1/CYCS	-0.834284619961669
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/990	102/9376	0.74280055456526	CA2/GNAS/RAB11A/PLA2G10/RAC1/ATP2B3/ADCY1/ATP1A4	-0.897351048111715
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/990	44/9376	0.645730027548209	HLA-G/HSPD1/GZMB	-0.809280587979316
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/990	68/9376	0.696375519904932	ALDH1A3/ALDH1A2/AOX1/RDH13/CYP2S1	-0.863353908939788
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/990	91/9376	0.728515928515929	RAC3/GRB2/PIK3CB/RAC1/PPP3CA/BLNK/VAV2	-0.894128426419378
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/990	168/9376	0.789225589225589	HMGB1/PPIA/HSP90AB1/PYGL/VDAC1/SLC25A5/CHMP4C/SLC25A4/TNFSF10/CHMP2A/CHMP2B/PGAM5/PARP1/AIFM1	-0.947143266100227
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/990	32/9376	0.591919191919192	ATG9B/ATG10	-0.794475577303968
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/990	32/9376	0.591919191919192	BIRC5/CYCS	-0.794475577303968
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/990	69/9376	0.68628312106573	RAC3/GRB2/PIK3CB/RAC1/VAV2	-0.898635105763411
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/990	45/9376	0.631380471380471	HLA-G/GZMB/KLRC1	-0.851620894023022
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/990	104/9376	0.728515928515929	PLA2G10/LYPLA1/PHOSPHO1/CDS1/AGPAT5/DGKZ/PLB1/GPD2	-0.956533354104613
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/990	93/9376	0.712848919300532	CALM1/GNAS/CALM3/ATP2B3/ADCY1/ATP1A4/ADRB1	-0.956166581052182
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/990	33/9376	0.573982246709519	VTI1B/BNIP1	-0.84230096774053
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/990	105/9376	0.721577681577682	CCL4/CCL21/CCL4L2/PPP1R13L/GADD45A/CXCL12/BLNK/PARP1	-0.985737346629208
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/990	105/9376	0.721577681577682	UBA52/RPS27A/BNIP3/TOMM20/FIS1/TP53/ATG9B/PGAM5	-0.985737346629208
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/990	71/9376	0.66695120216247	CGA/GRB2/PIK3CB/ELF5/TH	-0.967842440933585
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/990	140/9376	0.744126984126984	CALM1/RPS6/CDH1/CALM3/EGR1/NOS2/MYL4/GNG4/GNG5/APLNR/ADCY1	-1.04802670754488
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/990	95/9376	0.697841573631047	CTSL/ATP6V1C2/CCL3L1/ATP6V1B1/IL15/FLT1/CXCL12	-1.01700931985436
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/990	73/9376	0.648678566486786	GRB2/PIK3CB/EGFR/GADD45A/TP53	-1.03533375178564
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/990	49/9376	0.579839208410637	GNAS/MAOB/TH	-1.01313747716886
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/990	86/9376	0.660747004933051	SLC2A1/GNAS/ADCY1/ATP1A4/KCNMB1/KCNN2	-1.08590258150151
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/990	21/9376	0.450986050986051	ALDH1B1	-0.865360239298539
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/990	133/9376	0.712083238399028	CALM1/GNAS/PPP1CB/CALM3/GNG4/PPP3CA/GNG5/MAOB/TH/PPP1CA	-1.14897902162327
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/990	254/9376	0.783011214507278	CALM1/GNAS/ERBB3/CALM3/FLT4/VDAC1/SLC25A5/NOS2/EGFR/PLCD4/ATP2B3/PPP3CA/SLC25A4/CHRM5/MST1/ADCY1/FLT1/PTK2B/KDR/ADRB1/SLN	-1.20457797990857
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/990	99/9376	0.669645954494439	GNAS/GRB2/PIK3CB/EGFR/ADCY1/IGF1/TP53	-1.13532252651549
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/990	180/9376	0.736610549943883	HLA-G/CALR/ITGA5/PPP1CB/PIK3CB/SRSF3/CYCS/SRSF2/ALYREF/SRPK1/TP53/SRSF6/PPP1CA/TAP1	-1.22591667736722
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/990	226/9376	0.754304102976669	CGA/CALM1/GNAS/PPP1CB/CALM3/RAC3/PIK3CB/RAC1/ATP2B3/TIAM1/NPR1/ADCY1/ATP1A4/PDE4D/PAK1/ADRB1/PPP1CA/VAV2	-1.28459841872504
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/990	23/9376	0.411769872639438	THOP1	-0.970423983373394
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/990	205/9376	0.739177137225918	HLA-G/CCNE1/ISG15/CALR/PIK3CB/CCNA2/SKP2/RAC1/CYCS/PSMD14/GADD45A/PSMD11/TP53/BLNK/TAP1/PSMD4	-1.29729889347145
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/990	39/9376	0.485677285677286	HLA-G/GZMB	-1.10583450078462
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/990	103/9376	0.643640286358733	RBM8A/PPP1CB/PAPOLA/ALYREF/PPP1CA/UPF3B/MAGOH	-1.24946153329048
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/990	115/9376	0.658831796223101	GNAS/APP/GNG4/GNG5/CYP2J2/MAOB/SLC6A4/KCNN2	-1.2647780896738
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	15/990	196/9376	0.724799010513296	HLA-G/CALM1/UBA52/RPS27A/CTNNB1/CALM3/TCF7L2/PIK3CB/RAC1/GNG4/CYCS/PPP3CA/GNG5/TP53/CCR1	-1.3377732038845
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/990	54/9376	0.52615039281706	HLA-G/CGA/GZMB	-1.19979945965894
NA	NA	hsa04081	Hormone signaling	17/990	219/9376	0.735169042018357	DIO2/LEP/CGA/RAMP1/GNAS/GAST/PIK3CB/ADRA2C/GNG4/GNG5/INSR/NPR1/ADCY1/IGF1/ADRB1/THRB/NPPB	-1.36251097221769
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/990	105/9376	0.631380471380471	CALM1/CALM3/CBLB/PIK3CB/PPP3CA/IL17D/PAK1	-1.30507510359125
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	24/990	298/9376	0.762741509050234	LEP/EBI3/GDF15/CCL4/IL2RB/CCR7/IL1RAP/CCL3L1/IL1R2/CSF2RB/CCL21/CXCR6/BMP7/TNFSF10/CXCL13/IL15/INHA/CCL4L2/CSF2RA/IL17D/CXCL12/IL20RA/CCR1/GDF7	-1.4300809224125
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/990	154/9376	0.676479076479076	CALM1/ACTB/GNAS/PPP1CB/CALM3/ACTG1/EGFR/PPP3CA/NPR1/ADCY1/PPP1CA	-1.39083618663665
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/990	70/9376	0.541183261183261	LEP/SLC2A1/ACSL4/ACSL5	-1.32383102858482
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/990	83/9376	0.570524522331751	CBX3/AURKB/EZH2/SKP1/TFDP1	-1.35028441627374
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/990	323/9376	0.762347937580136	CCNE1/EFNA1/TPM1/STMN1/EZR/ITGA5/SOX4/ERBB3/GRB2/PIK3CB/SLC7A1/TRIM71/EZH2/DNMT1/HMGA2/EGFR/KIF23/CDCA5/HNRNPK/TP53/BRCA1/CDC25C/TP63/EFNA3/EFNA4/DNMT3B	-1.49338709828141
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/990	43/9376	0.440498003288701	PLA2G10/ACAT2	-1.26342958438035
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/990	157/9376	0.663552724699222	SLC2A1/PPARG/CALR/SLC16A1/RAC1/ARG2/ODC1/DUSP5/TMEM30B/DUSP4/ATP11A	-1.46066539607642
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/990	97/9376	0.585816932208685	CALM1/GNAS/CALM3/GNG4/GNG5/ADCY1	-1.40881324747491
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/990	122/9376	0.621029971849644	CDC42/CBLB/GRB2/PIK3CB/PPP3CA/PAK3/PAK1/VAV2	-1.44759087959819
Human Diseases	Infectious disease: viral	hsa05162	Measles	9/990	136/9376	0.626737967914438	CCNE1/HSPA8/IL2RB/CBLB/PIK3CB/CYCS/EIF3H/TP53/MX1	-1.50651371974886
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/990	149/9376	0.635617924208528	GNAS/GRB2/PIK3CB/EGFR/INSR/ADCY1/PTK2B/DNM2/AGPAT5/DGKZ	-1.54044318765865
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/990	100/9376	0.568242424242424	CD55/ITGA5/GYPA/IL1R2/ITGA6/CSF2RA	-1.49137000126487
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/990	173/9376	0.656927658083727	ACTB/RAB11A/VDAC1/SLC25A5/PIK3CB/ACTG1/KPNA2/FDPS/CYCS/SLC25A4/TNFSF10/MX1	-1.56483969474086
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/990	103/9376	0.551691674021771	COL4A1/COL4A2/SLC6A19/COL6A3/COL27A1/ATP1A4	-1.57184997888824
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/990	103/9376	0.551691674021771	CALR/GNAS/PIK3CB/CCL3L1/NOS2/ADCY1	-1.57184997888824
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/990	77/9376	0.491984782893874	GRB2/PIK3CB/GADD45A/TP53	-1.53790591234995
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/990	91/9376	0.52036852036852	GNAS/GNG4/GNG5/ADCY1/PDE4D	-1.57965857002131
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/990	50/9376	0.378828282828283	IL15/CXCL12	-1.51312489461125
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/990	109/9376	0.52132332499305	GATA3/EBI3/HSP90AB1/IL2RB/IL1RAP/PPP3CA	-1.72707715510853
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/990	55/9376	0.344389348025712	GM2A/DEGS2	-1.67541306715684
Human Diseases	Substance dependence	hsa05034	Alcoholism	12/990	191/9376	0.595018245280025	CALM1/GNAS/PPP1CB/CALM3/GRB2/GNG4/GNG5/SLC29A2/SLC29A1/MAOB/TH/PPP1CA	-1.94284595526854
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/990	73/9376	0.389207139892071	RAN/PPIA/MX1	-1.79998828165899
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/990	168/9376	0.563732563732564	LEP/IL2RB/GRB2/PIK3CB/EGFR/CSF2RB/AOX1/IL15/CSF2RA/IL20RA	-1.96042661422388
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/990	90/9376	0.420920314253648	PIK3CB/EGFR/PPP3CA/CD274	-1.89657949815329
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/990	60/9376	0.315690235690236	GNAS/IGF1	-1.82700370745112
NA	NA	hsa04082	Neuroactive ligand signaling	12/990	199/9376	0.571097913811482	GNAS/ADRA2C/GNG4/GNG5/P2RY14/CHRM5/SLC6A11/SLC1A6/ADCY1/SLC6A4/SLC1A2/ADRB1	-2.10116490089508
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/990	78/9376	0.364257964257964	ITGB1/NOS2/MARCKSL1	-1.93713222183166
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/990	62/9376	0.305506679700228	HEY1/TLE1	-1.88504450186317
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/990	94/9376	0.40300881151945	HSP90AB1/S100A9/TRAF4/IL17D	-1.99865057230412
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/990	109/9376	0.434436104160875	CCL4/PIK3CB/CCL3L1/RAC1/CCL4L2	-2.04056837372273
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/990	125/9376	0.454593939393939	RAC3/PIK3CB/PRKCZ/RAC1/TP53/DEGS2	-2.10914497232159
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/990	142/9376	0.466865841513729	PPARG/GRB2/PIK3CB/RAC1/PPP3CA/FHL2/BLNK	-2.19943713163828
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/990	115/9376	0.411769872639438	PIK3CB/GNG4/GNG5/CHRM5/ADCY1	-2.18068556370564
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/990	144/9376	0.460381593714927	CTNNB1/SCD/TCF7L2/FASN/ALDH7A1/TRA2A/ALDH1B1	-2.24205318004688
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/990	72/9376	0.26307519640853	ISG15/DDX3X	-2.15665351811186
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/990	122/9376	0.388143732406027	GNAS/GRB2/PIK3CB/ADCY1/IGF1	-2.33717045360278
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/990	93/9376	0.305506679700228	GATA3/IL2RB/PPP3CA	-2.31255025061043
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/990	169/9376	0.448317494471341	HMGB1/UBA52/RPS27A/BNIP3/CTSL/PIK3CB/ATG9B/ATG10	-2.48656204004321
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/990	56/9376	0.169119769119769	LRP2	-2.14264533529852
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	13/990	250/9376	0.492476767676768	CTSV/AP1M2/CTSL/GM2A/ATP6V1C2/CLTA/ATP6V1B1/CTSE/SLC29A2/SLC29A1/SLC38A9/CTSW/LAMTOR2	-2.79454756402699
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/990	66/9376	0.14349556167738	GATA3	-2.39912320581537
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/990	195/9376	0.388541828541829	HMGB1/ACTB/VDAC1/SLC25A5/PIK3CB/ACTG1/RAC1/SLC25A4	-2.96459158606399
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/990	181/9376	0.366270439198616	CALM1/CALM3/HSPD1/NOS2/CYCS/PPP3CA/NFYB	-2.95796610194482
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/990	119/9376	0.238757321110262	PIK3CB/IL15/PGAM5	-2.8713576075453
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/990	143/9376	0.264914883096701	SNRPD1/SNRPB/ACTN1/SNRPD3	-3.0434070141151
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/990	183/9376	0.310514985924822	RAN/NHP2/FBL/POP7/IMP4/NOP56	-3.23629090340756
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/990	187/9376	0.303872954140334	TXN/YWHAE/HSP90AB1/VDAC1/TXN2/SUGT1	-3.3037029506661
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/990	370/9376	0.460737100737101	LEP/CGA/KISS1/GAL/KISS1R/GZMA/ADM/ADRA2C/TMEM97/CHRNA5/P2RY14/VGF/RLN2/CHRM5/APLNR/ADRB1/THRB/CALCRL	-3.63631284013392
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/990	449/9376	0.0421857775978043	CALM1/CALM3	-7.14623824908144