ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 97/1721 175/18639 0.554285714285714 6.0030978666888 3.07272089656433e-54 3.73028316842909e-51 GO:0045296 cadherin binding 93/1721 334/18639 0.278443113772455 3.01563114329157 5.06448883207162e-23 3.07414472106747e-20 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 27/1721 68/18639 0.397058823529412 4.30027856581331 1.52773454661509e-11 6.18223246530241e-09 GO:0009055 electron transfer activity 35/1721 116/18639 0.301724137931034 3.26777234566912 1.45702801332787e-10 4.42208002045008e-08 GO:0004601 peroxidase activity 23/1721 57/18639 0.403508771929825 4.37013364323068 3.330160253636e-10 8.08562909582821e-08 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 23/1721 59/18639 0.389830508474576 4.22199351973133 7.5391199109484e-10 1.52541526198189e-07 GO:0022853 active monoatomic ion transmembrane transporter activity 33/1721 118/18639 0.279661016949153 3.02882143806813 4.18314313162171e-09 6.66194860740612e-07 GO:0031720 haptoglobin binding 9/1721 10/18639 0.9 9.74729808251017 4.39008145463336e-09 6.66194860740612e-07 GO:0019843 rRNA binding 23/1721 65/18639 0.353846153846154 3.8322710409869 6.87844518341529e-09 8.43171164907386e-07 GO:0016209 antioxidant activity 27/1721 86/18639 0.313953488372093 3.40022026134076 6.94539674553036e-09 8.43171164907386e-07 GO:0048027 mRNA 5'-UTR binding 13/1721 24/18639 0.541666666666667 5.86642940151075 3.19778924695981e-08 3.52919649619018e-06 GO:0015399 primary active transmembrane transporter activity 39/1721 166/18639 0.234939759036145 2.5444754030649 3.63572283015823e-08 3.67813959651008e-06 GO:0003743 translation initiation factor activity 18/1721 51/18639 0.352941176470588 3.8224698362785 3.11339473965588e-07 2.90743170303249e-05 GO:0005344 oxygen carrier activity 9/1721 14/18639 0.642857142857143 6.96235577322155 6.22751322299998e-07 5.38384510504097e-05 GO:1990948 ubiquitin ligase inhibitor activity 8/1721 11/18639 0.727272727272727 7.87660451111933 6.65219741150038e-07 5.38384510504097e-05 GO:0003779 actin binding 73/1721 443/18639 0.164785553047404 1.78468211693815 7.33791073832642e-07 5.56763977270517e-05 GO:0003954 NADH dehydrogenase activity 16/1721 44/18639 0.363636363636364 3.93830225555966 8.85100763986105e-07 6.32066074987724e-05 GO:0008135 translation factor activity, RNA binding 23/1721 83/18639 0.27710843373494 3.00117611643553 1.08502799909706e-06 7.31791106057686e-05 GO:0180051 translation factor activity 23/1721 84/18639 0.273809523809524 2.9654478293351 1.36477998703165e-06 8.25917423148596e-05 GO:0004129 cytochrome-c oxidase activity 9/1721 15/18639 0.6 6.49819872167345 1.4286874700264e-06 8.25917423148596e-05 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/1721 15/18639 0.6 6.49819872167345 1.4286874700264e-06 8.25917423148596e-05 GO:0008137 NADH dehydrogenase (ubiquinone) activity 15/1721 41/18639 0.365853658536585 3.96231629370332 1.77548384062025e-06 9.79744264778628e-05 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 18/1721 58/18639 0.310344827586207 3.36113726983109 2.67903139914127e-06 0.000141406266024239 GO:0016675 oxidoreductase activity, acting on a heme group of donors 9/1721 16/18639 0.5625 6.09206130156886 2.99693951006103e-06 0.000147715266321628 GO:0016860 intramolecular oxidoreductase activity 17/1721 53/18639 0.320754716981132 3.47387981976253 3.0419124036579e-06 0.000147715266321628 GO:0031625 ubiquitin protein ligase binding 53/1721 302/18639 0.175496688741722 1.90068726406563 3.70296730073373e-06 0.000172900088580413 GO:0003697 single-stranded DNA binding 28/1721 121/18639 0.231404958677686 2.50619234444706 4.04368498930678e-06 0.000175322627750658 GO:0051082 unfolded protein binding 28/1721 121/18639 0.231404958677686 2.50619234444706 4.04368498930678e-06 0.000175322627750658 GO:0019825 oxygen binding 13/1721 34/18639 0.382352941176471 4.14100898930171 4.9154266084513e-06 0.000205769927677927 GO:0044389 ubiquitin-like protein ligase binding 55/1721 322/18639 0.170807453416149 1.84990129240186 5.66609526656505e-06 0.000229287988453666 GO:0051015 actin filament binding 40/1721 209/18639 0.191387559808612 2.07279066082088 6.83256106984414e-06 0.000263666250992471 GO:0015036 disulfide oxidoreductase activity 14/1721 40/18639 0.35 3.79061592097618 7.1672045162698e-06 0.000263666250992471 GO:0140662 ATP-dependent protein folding chaperone 14/1721 40/18639 0.35 3.79061592097618 7.1672045162698e-06 0.000263666250992471 GO:0015078 proton transmembrane transporter activity 36/1721 185/18639 0.194594594594595 2.10752390973193 1.32079610230811e-05 0.000471601902412366 GO:0022804 active transmembrane transporter activity 70/1721 457/18639 0.153172866520788 1.65891287570073 1.64851811988374e-05 0.000571800285011104 GO:0015035 protein-disulfide reductase activity 12/1721 34/18639 0.352941176470588 3.8224698362785 2.93607527123028e-05 0.00099010982757599 GO:0003688 DNA replication origin binding 8/1721 16/18639 0.5 5.41516560139454 3.39609911726711e-05 0.00111428765631413 GO:0055106 ubiquitin-protein transferase regulator activity 12/1721 36/18639 0.333333333333333 3.61011040092969 5.62828167798634e-05 0.0017980878834409 GO:0031994 insulin-like growth factor I binding 7/1721 13/18639 0.538461538461538 5.83171680150181 5.87921622002925e-05 0.00183009448490141 GO:0098641 cadherin binding involved in cell-cell adhesion 8/1721 18/18639 0.444444444444444 4.81348053457292 9.75308918710491e-05 0.00296006256828634 GO:0019838 growth factor binding 27/1721 136/18639 0.198529411764706 2.15013928290665 0.00010684361307998 0.00316361332388037 GO:0016651 oxidoreductase activity, acting on NAD(P)H 20/1721 88/18639 0.227272727272727 2.46143890972479 0.000121044887301182 0.0034987736472294 GO:0044183 protein folding chaperone 18/1721 75/18639 0.24 2.59927948866938 0.000124621903788575 0.00351839514417048 GO:0098631 cell adhesion mediator activity 18/1721 76/18639 0.236842105263158 2.56507844276583 0.000149386160362491 0.00412169997000146 GO:0005520 insulin-like growth factor binding 8/1721 19/18639 0.421052631578947 4.56013945380593 0.000154851238429623 0.00417754229896806 GO:0005536 D-glucose binding 6/1721 11/18639 0.545454545454545 5.9074533833395 0.000188608309833033 0.00497761930733266 GO:0008017 microtubule binding 44/1721 276/18639 0.159420289855072 1.72657453957507 0.000239281914733059 0.00618060094650921 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 14/1721 54/18639 0.259259259259259 2.80786364516754 0.000292127544036592 0.00738839246792547 GO:0004857 enzyme inhibitor activity 60/1721 416/18639 0.144230769230769 1.56206700040227 0.000342460568430869 0.00848463530765459 GO:0070182 DNA polymerase binding 8/1721 21/18639 0.380952380952381 4.12584045820536 0.000352375913739263 0.00854525601479906 GO:0098632 cell-cell adhesion mediator activity 14/1721 55/18639 0.254545454545455 2.75681157889176 0.000358985219732085 0.00854525601479906 GO:0043021 ribonucleoprotein complex binding 31/1721 177/18639 0.175141242937853 1.89683766828509 0.000374501950455875 0.00874318015102755 GO:0030515 snoRNA binding 10/1721 32/18639 0.3125 3.38447850087159 0.00042361566285283 0.00970319650383653 GO:0140517 protein-RNA adaptor activity 8/1721 22/18639 0.363636363636364 3.93830225555966 0.000509163835179391 0.0113096360886297 GO:0005200 structural constituent of cytoskeleton 22/1721 112/18639 0.196428571428571 2.12738648626214 0.000521696557630363 0.0113096360886297 GO:0043022 ribosome binding 22/1721 112/18639 0.196428571428571 2.12738648626214 0.000521696557630363 0.0113096360886297 GO:0000217 DNA secondary structure binding 11/1721 39/18639 0.282051282051282 3.05470880078666 0.000591258167582043 0.0125927616744667 GO:0015631 tubulin binding 55/1721 385/18639 0.142857142857143 1.54719017182701 0.000745822318888015 0.015610832674656 GO:0043236 laminin binding 9/1721 29/18639 0.310344827586207 3.36113726983109 0.000866541484871843 0.017830192587024 GO:0003756 protein disulfide isomerase activity 7/1721 19/18639 0.368421052631579 3.99012202208019 0.00105008591783698 0.0208984312172802 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 7/1721 19/18639 0.368421052631579 3.99012202208019 0.00105008591783698 0.0208984312172802 GO:0016853 isomerase activity 30/1721 180/18639 0.166666666666667 1.80505520046485 0.00106796145364541 0.0209113742697666 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/1721 15/18639 0.4 4.33213248111563 0.00147680840019604 0.0275822368898153 GO:0031386 protein tag activity 6/1721 15/18639 0.4 4.33213248111563 0.00147680840019604 0.0275822368898153 GO:0141047 molecular tag activity 6/1721 15/18639 0.4 4.33213248111563 0.00147680840019604 0.0275822368898153 GO:0050786 RAGE receptor binding 5/1721 11/18639 0.454545454545455 4.92287781944958 0.00191588818852408 0.0352407312252763 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 11/1721 46/18639 0.239130434782609 2.58986180936261 0.00258078843759003 0.0467623457199148 GO:0051087 protein-folding chaperone binding 23/1721 134/18639 0.171641791044776 1.85893744525484 0.00263432721591234 0.0469242032756004 GO:0019842 vitamin binding 25/1721 150/18639 0.166666666666667 1.80505520046485 0.00266702638057366 0.0469242032756004 GO:0097718 disordered domain specific binding 8/1721 28/18639 0.285714285714286 3.09438034365402 0.0029986637383736 0.0519114139989499 GO:0097371 MDM2/MDM4 family protein binding 5/1721 12/18639 0.416666666666667 4.51263800116211 0.00303600526682491 0.0519114139989499 GO:0004029 aldehyde dehydrogenase (NAD+) activity 6/1721 17/18639 0.352941176470588 3.8224698362785 0.0031076833045135 0.0523989934955471 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 13/1721 61/18639 0.213114754098361 2.3081033710862 0.00329321062735895 0.0547665438577228 GO:0061650 ubiquitin-like protein conjugating enzyme activity 10/1721 41/18639 0.24390243902439 2.64154419580221 0.00342005392092385 0.056041148235723 GO:0005178 integrin binding 26/1721 161/18639 0.161490683229814 1.74899758554358 0.00346217966859903 0.056041148235723 GO:0004602 glutathione peroxidase activity 7/1721 23/18639 0.304347826086957 3.29618775737059 0.00367791240709892 0.0587498113449748 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 6/1721 18/18639 0.333333333333333 3.61011040092969 0.00430139364932155 0.0678167777957969 GO:0016887 ATP hydrolysis activity 55/1721 417/18639 0.13189448441247 1.42846095000815 0.00445524831946403 0.0683646237976896 GO:0005542 folic acid binding 5/1721 13/18639 0.384615384615385 4.16551200107272 0.00456139582175689 0.0683646237976896 GO:0043560 insulin receptor substrate binding 5/1721 13/18639 0.384615384615385 4.16551200107272 0.00456139582175689 0.0683646237976896 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/1721 13/18639 0.384615384615385 4.16551200107272 0.00456139582175689 0.0683646237976896 GO:0140104 molecular carrier activity 36/1721 249/18639 0.144578313253012 1.56583101727071 0.00463285975520068 0.0685889236928491 GO:0008301 DNA binding, bending 6/1721 19/18639 0.315789473684211 3.42010459035445 0.00580199721769905 0.0848629472564656 GO:0019205 nucleobase-containing compound kinase activity 10/1721 44/18639 0.227272727272727 2.46143890972479 0.0058724809175625 0.0848713313562008 GO:0046906 tetrapyrrole binding 24/1721 152/18639 0.157894736842105 1.71005229517722 0.0064421187525625 0.091562746530198 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 5/1721 14/18639 0.357142857142857 3.86797542956753 0.00656174542679343 0.091562746530198 GO:0044548 S100 protein binding 5/1721 14/18639 0.357142857142857 3.86797542956753 0.00656174542679343 0.091562746530198 GO:0001618 virus receptor activity 15/1721 81/18639 0.185185185185185 2.00561688940538 0.00675611250607561 0.0932036429815431 GO:0000287 magnesium ion binding 33/1721 230/18639 0.143478260869565 1.55391708561756 0.00728683966498119 0.0993957680144625 GO:0140272 exogenous protein binding 15/1721 82/18639 0.182926829268293 1.98115814685166 0.00758098858543159 0.102068786765455 GO:0043024 ribosomal small subunit binding 6/1721 20/18639 0.3 3.24909936083672 0.00765095518587845 0.102068786765455 GO:0030145 manganese ion binding 13/1721 68/18639 0.191176470588235 2.07050449465085 0.0086058775020166 0.112339089112346 GO:1990841 promoter-specific chromatin binding 13/1721 68/18639 0.191176470588235 2.07050449465085 0.0086058775020166 0.112339089112346 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 9/1721 40/18639 0.225 2.43682452062754 0.00939054183764039 0.118324355668265 GO:0001094 TFIID-class transcription factor complex binding 4/1721 10/18639 0.4 4.33213248111563 0.00964918551166248 0.118324355668265 GO:0003680 minor groove of adenine-thymine-rich DNA binding 4/1721 10/18639 0.4 4.33213248111563 0.00964918551166248 0.118324355668265 GO:0005345 purine nucleobase transmembrane transporter activity 4/1721 10/18639 0.4 4.33213248111563 0.00964918551166248 0.118324355668265 GO:0047429 nucleoside triphosphate diphosphatase activity 4/1721 10/18639 0.4 4.33213248111563 0.00964918551166248 0.118324355668265 GO:0050815 phosphoserine residue binding 4/1721 10/18639 0.4 4.33213248111563 0.00964918551166248 0.118324355668265 GO:0020037 heme binding 22/1721 142/18639 0.154929577464789 1.67793863705183 0.0109599771681513 0.133054122821357 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/1721 41/18639 0.219512195121951 2.37738977622199 0.0110697415642169 0.133056101573855 GO:0140097 catalytic activity, acting on DNA 44/1721 336/18639 0.130952380952381 1.41825765750809 0.0114375691165169 0.134962532849291 GO:0019887 protein kinase regulator activity 35/1721 255/18639 0.137254901960784 1.48651604744164 0.0114506926552529 0.134962532849291 GO:0005159 insulin-like growth factor receptor binding 5/1721 16/18639 0.3125 3.38447850087159 0.0122517697055893 0.141653794500814 GO:0017070 U6 snRNA binding 5/1721 16/18639 0.3125 3.38447850087159 0.0122517697055893 0.141653794500814 GO:0004523 RNA-DNA hybrid ribonuclease activity 4/1721 11/18639 0.363636363636364 3.93830225555966 0.0140682125534559 0.155019378350814 GO:0015205 nucleobase transmembrane transporter activity 4/1721 11/18639 0.363636363636364 3.93830225555966 0.0140682125534559 0.155019378350814 GO:0034056 estrogen response element binding 4/1721 11/18639 0.363636363636364 3.93830225555966 0.0140682125534559 0.155019378350814 GO:0034511 U3 snoRNA binding 4/1721 11/18639 0.363636363636364 3.93830225555966 0.0140682125534559 0.155019378350814 GO:0047676 arachidonate-CoA ligase activity 4/1721 11/18639 0.363636363636364 3.93830225555966 0.0140682125534559 0.155019378350814 GO:0048306 calcium-dependent protein binding 14/1721 80/18639 0.175 1.89530796048809 0.0141739299810052 0.155019378350814 GO:0015101 organic cation transmembrane transporter activity 14/1721 81/18639 0.172839506172839 1.87190909677836 0.0157239216921845 0.169556801105475 GO:0017116 single-stranded DNA helicase activity 11/1721 58/18639 0.189655172413793 2.05402833156345 0.0158838926322774 0.169556801105475 GO:0004550 nucleoside diphosphate kinase activity 5/1721 17/18639 0.294117647058824 3.18539153023208 0.0160618057060376 0.169556801105475 GO:1990226 histone methyltransferase binding 5/1721 17/18639 0.294117647058824 3.18539153023208 0.0160618057060376 0.169556801105475 GO:0003678 DNA helicase activity 13/1721 74/18639 0.175675675675676 1.90262575184132 0.0171712398471279 0.177310982312078 GO:0003684 damaged DNA binding 13/1721 74/18639 0.175675675675676 1.90262575184132 0.0171712398471279 0.177310982312078 GO:0016829 lyase activity 28/1721 200/18639 0.14 1.51624636839047 0.0172345106365941 0.177310982312078 GO:0045309 protein phosphorylated amino acid binding 11/1721 59/18639 0.186440677966102 2.01921429204542 0.0179441712254631 0.183060704770691 GO:0017124 SH3 domain binding 18/1721 115/18639 0.156521739130435 1.69518227521916 0.0181885532593124 0.184007530473377 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/1721 24/18639 0.25 2.70758280069727 0.0193247700570561 0.191736773087745 GO:0050699 WW domain binding 6/1721 24/18639 0.25 2.70758280069727 0.0193247700570561 0.191736773087745 GO:0004859 phospholipase inhibitor activity 4/1721 12/18639 0.333333333333333 3.61011040092969 0.0195843161967714 0.191736773087745 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/1721 12/18639 0.333333333333333 3.61011040092969 0.0195843161967714 0.191736773087745 GO:0000400 four-way junction DNA binding 5/1721 18/18639 0.277777777777778 3.00842533410808 0.0205850411124668 0.19758269289796 GO:0031690 adrenergic receptor binding 5/1721 18/18639 0.277777777777778 3.00842533410808 0.0205850411124668 0.19758269289796 GO:0005109 frizzled binding 8/1721 38/18639 0.210526315789474 2.28006972690296 0.0206807339205959 0.19758269289796 GO:0003777 microtubule motor activity 12/1721 68/18639 0.176470588235294 1.91123491813925 0.0208324420847932 0.19758269289796 GO:0051117 ATPase binding 14/1721 84/18639 0.166666666666667 1.80505520046485 0.021157205067292 0.199107340710795 GO:0031369 translation initiation factor binding 7/1721 32/18639 0.21875 2.36913495061011 0.0243184312806417 0.2250333625015 GO:0017069 snRNA binding 10/1721 54/18639 0.185185185185185 2.00561688940538 0.0244682074548583 0.2250333625015 GO:0051287 NAD binding 10/1721 54/18639 0.185185185185185 2.00561688940538 0.0244682074548583 0.2250333625015 GO:0044325 transmembrane transporter binding 20/1721 136/18639 0.147058823529412 1.59269576511604 0.0248879099944117 0.227172351377562 GO:0008574 plus-end-directed microtubule motor activity 5/1721 19/18639 0.263157894736842 2.8500871586287 0.0258646996463125 0.229360143970419 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5/1721 19/18639 0.263157894736842 2.8500871586287 0.0258646996463125 0.229360143970419 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/1721 13/18639 0.307692307692308 3.33240960085818 0.0262611696967778 0.229360143970419 GO:0019855 calcium channel inhibitor activity 4/1721 13/18639 0.307692307692308 3.33240960085818 0.0262611696967778 0.229360143970419 GO:0061459 L-arginine transmembrane transporter activity 4/1721 13/18639 0.307692307692308 3.33240960085818 0.0262611696967778 0.229360143970419 GO:0140666 annealing activity 4/1721 13/18639 0.307692307692308 3.33240960085818 0.0262611696967778 0.229360143970419 GO:0005507 copper ion binding 11/1721 63/18639 0.174603174603175 1.89101021001079 0.028201094990911 0.24348176447073 GO:0016835 carbon-oxygen lyase activity 13/1721 79/18639 0.164556962025316 1.78220640045896 0.0282791835176054 0.24348176447073 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7/1721 33/18639 0.212121212121212 2.2973429824098 0.0284820536793387 0.243501501174064 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/1721 48/18639 0.1875 2.03068710052295 0.0296756997638971 0.251932164429168 GO:0019212 phosphatase inhibitor activity 10/1721 56/18639 0.178571428571429 1.93398771478376 0.0308224093102024 0.259850034045734 GO:0031072 heat shock protein binding 19/1721 131/18639 0.145038167938931 1.57081139582437 0.0320636667527765 0.268450285778418 GO:0090482 vitamin transmembrane transporter activity 7/1721 34/18639 0.205882352941176 2.22977407116246 0.0331021344486644 0.275246515210127 GO:0004364 glutathione transferase activity 6/1721 27/18639 0.222222222222222 2.40674026728646 0.0335414862759797 0.27631400291595 GO:0032036 myosin heavy chain binding 4/1721 14/18639 0.285714285714286 3.09438034365402 0.0341409394047715 0.27631400291595 GO:0070742 C2H2 zinc finger domain binding 4/1721 14/18639 0.285714285714286 3.09438034365402 0.0341409394047715 0.27631400291595 GO:1990825 sequence-specific mRNA binding 4/1721 14/18639 0.285714285714286 3.09438034365402 0.0341409394047715 0.27631400291595 GO:0038024 cargo receptor activity 11/1721 65/18639 0.169230769230769 1.832825280472 0.0346657095871973 0.278703122111639 GO:0004520 DNA endonuclease activity 8/1721 42/18639 0.19047619047619 2.06292022910268 0.0360286230710654 0.28401784680697 GO:0031492 nucleosomal DNA binding 8/1721 42/18639 0.19047619047619 2.06292022910268 0.0360286230710654 0.28401784680697 GO:0051879 Hsp90 protein binding 8/1721 42/18639 0.19047619047619 2.06292022910268 0.0360286230710654 0.28401784680697 GO:0019207 kinase regulator activity 36/1721 287/18639 0.125435540069686 1.35850844355542 0.0364213155531552 0.285261142461487 GO:0008514 organic anion transmembrane transporter activity 34/1721 269/18639 0.12639405204461 1.36888944570568 0.0374215539623849 0.291216451989329 GO:0061631 ubiquitin conjugating enzyme activity 7/1721 35/18639 0.2 2.16606624055782 0.0381953979057596 0.295345306099313 GO:0019200 carbohydrate kinase activity 5/1721 21/18639 0.238095238095238 2.57865028637835 0.0388255704660346 0.297588660007873 GO:0072341 modified amino acid binding 14/1721 91/18639 0.153846153846154 1.66620480042909 0.039161550943631 0.297588660007873 GO:0046875 ephrin receptor binding 6/1721 28/18639 0.214285714285714 2.32078525774052 0.0394660414013735 0.297588660007873 GO:0051537 2 iron, 2 sulfur cluster binding 6/1721 28/18639 0.214285714285714 2.32078525774052 0.0394660414013735 0.297588660007873 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/1721 43/18639 0.186046511627907 2.01494534005378 0.0408149381415336 0.3058600919989 GO:0050840 extracellular matrix binding 11/1721 67/18639 0.164179104477612 1.77811407806985 0.0421084309387435 0.31361739361739 GO:0003774 cytoskeletal motor activity 21/1721 153/18639 0.137254901960784 1.48651604744164 0.0426402596339953 0.315641921924819 GO:0004467 long-chain fatty acid-CoA ligase activity 4/1721 15/18639 0.266666666666667 2.88808832074375 0.0432452032101094 0.316263112632969 GO:0016846 carbon-sulfur lyase activity 4/1721 15/18639 0.266666666666667 2.88808832074375 0.0432452032101094 0.316263112632969 GO:0140789 histone phosphatase activity 19/1721 136/18639 0.139705882352941 1.51306097686024 0.0446209758224684 0.324370446996866 GO:0003785 actin monomer binding 6/1721 29/18639 0.206896551724138 2.2407581798874 0.0460139126583494 0.330537810457019 GO:0004629 phospholipase C activity 6/1721 29/18639 0.206896551724138 2.2407581798874 0.0460139126583494 0.330537810457019 GO:0070034 telomerase RNA binding 5/1721 22/18639 0.227272727272727 2.46143890972479 0.0465518582722752 0.33243503495613 GO:0008094 ATP-dependent activity, acting on DNA 27/1721 210/18639 0.128571428571429 1.39247115464431 0.049064248784722 0.347369729144684 GO:0051540 metal cluster binding 12/1721 77/18639 0.155844155844156 1.68784382381128 0.049215480570746 0.347369729144684 GO:0004867 serine-type endopeptidase inhibitor activity 14/1721 95/18639 0.147368421052632 1.59604880883207 0.0533474198863064 0.367820040258913 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/1721 16/18639 0.25 2.70758280069727 0.0535763477116161 0.367820040258913 GO:0055102 lipase inhibitor activity 4/1721 16/18639 0.25 2.70758280069727 0.0535763477116161 0.367820040258913 GO:0005283 amino acid:sodium symporter activity 5/1721 23/18639 0.217391304347826 2.35441982669328 0.0551246793637867 0.367820040258913 GO:0099186 structural constituent of postsynapse 5/1721 23/18639 0.217391304347826 2.35441982669328 0.0551246793637867 0.367820040258913 GO:0008028 monocarboxylic acid transmembrane transporter activity 11/1721 70/18639 0.157142857142857 1.70190918900971 0.0552255330762444 0.367820040258913 GO:0042162 telomeric DNA binding 7/1721 38/18639 0.184210526315789 1.99506101104009 0.0564438925701242 0.367820040258913 GO:0015179 L-amino acid transmembrane transporter activity 10/1721 62/18639 0.161290322580645 1.74682761335308 0.0566415469114751 0.367820040258913 GO:0005522 profilin binding 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0005528 FK506 binding 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0030957 Tat protein binding 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0031996 thioesterase binding 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0035374 chondroitin sulfate binding 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0098505 G-rich strand telomeric DNA binding 3/1721 10/18639 0.3 3.24909936083672 0.0575665631377212 0.367820040258913 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/1721 39/18639 0.179487179487179 1.9439056005006 0.0635462110288128 0.401293453949166 GO:0004622 lysophospholipase activity 5/1721 24/18639 0.208333333333333 2.25631900058106 0.0645457081287157 0.401293453949166 GO:0005540 hyaluronic acid binding 5/1721 24/18639 0.208333333333333 2.25631900058106 0.0645457081287157 0.401293453949166 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/1721 89/18639 0.146067415730337 1.58195849029503 0.0646906967547477 0.401293453949166 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/1721 89/18639 0.146067415730337 1.58195849029503 0.0646906967547477 0.401293453949166 GO:0046943 carboxylic acid transmembrane transporter activity 24/1721 188/18639 0.127659574468085 1.38259547269648 0.0648021371564146 0.401293453949166 GO:0005092 GDP-dissociation inhibitor activity 4/1721 17/18639 0.235294117647059 2.54831322418566 0.0651192837133326 0.401293453949166 GO:0004536 DNA nuclease activity 10/1721 64/18639 0.15625 1.69223925043579 0.0676915061486945 0.40583000793068 GO:0005342 organic acid transmembrane transporter activity 24/1721 189/18639 0.126984126984127 1.37528015273512 0.0680177073283653 0.40583000793068 GO:0140793 histone H2AXY142 phosphatase activity 13/1721 90/18639 0.144444444444444 1.5643811737362 0.0695206423383797 0.40583000793068 GO:0030170 pyridoxal phosphate binding 9/1721 56/18639 0.160714285714286 1.74058894330539 0.0696595375352588 0.40583000793068 GO:0140297 DNA-binding transcription factor binding 55/1721 488/18639 0.112704918032787 1.22063159047828 0.0702816584049581 0.40583000793068 GO:0043539 protein serine/threonine kinase activator activity 11/1721 73/18639 0.150684931506849 1.63196771548876 0.0708121828988975 0.40583000793068 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/1721 48/18639 0.166666666666667 1.80505520046485 0.0709667723761839 0.40583000793068 GO:0030331 nuclear estrogen receptor binding 7/1721 40/18639 0.175 1.89530796048809 0.0711663808402224 0.40583000793068 GO:0061791 GTPase motor activity 7/1721 40/18639 0.175 1.89530796048809 0.0711663808402224 0.40583000793068 GO:0071949 FAD binding 7/1721 40/18639 0.175 1.89530796048809 0.0711663808402224 0.40583000793068 GO:1990606 membrane scission GTPase motor activity 7/1721 40/18639 0.175 1.89530796048809 0.0711663808402224 0.40583000793068 GO:0019903 protein phosphatase binding 19/1721 144/18639 0.131944444444444 1.42900203370134 0.0714938406938783 0.40583000793068 GO:1990782 protein tyrosine kinase binding 16/1721 117/18639 0.136752136752137 1.48107093371475 0.0718493901645882 0.40583000793068 GO:0003713 transcription coactivator activity 31/1721 256/18639 0.12109375 1.31148541908774 0.0718520594190715 0.40583000793068 GO:0000099 sulfur amino acid transmembrane transporter activity 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0010854 adenylate cyclase regulator activity 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0015173 aromatic amino acid transmembrane transporter activity 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0019206 nucleoside kinase activity 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0019215 intermediate filament binding 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0045294 alpha-catenin binding 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0070990 snRNP binding 3/1721 11/18639 0.272727272727273 2.95372669166975 0.0738784446068206 0.40583000793068 GO:0005506 iron ion binding 20/1721 154/18639 0.12987012987013 1.40653651984274 0.074857342324727 0.40935501613612 GO:0051020 GTPase binding 37/1721 315/18639 0.117460317460317 1.27213414127999 0.0762446886176262 0.411329506618074 GO:0070279 vitamin B6 binding 9/1721 57/18639 0.157894736842105 1.71005229517722 0.0762706322550792 0.411329506618074 GO:0031491 nucleosome binding 11/1721 74/18639 0.148648648648649 1.60991409771189 0.0765736972781588 0.411329506618074 GO:0048029 monosaccharide binding 11/1721 74/18639 0.148648648648649 1.60991409771189 0.0765736972781588 0.411329506618074 GO:0000900 mRNA regulatory element binding translation repressor activity 4/1721 18/18639 0.222222222222222 2.40674026728646 0.0778433530278656 0.414481713051881 GO:0003746 translation elongation factor activity 4/1721 18/18639 0.222222222222222 2.40674026728646 0.0778433530278656 0.414481713051881 GO:0019956 chemokine binding 6/1721 33/18639 0.181818181818182 1.96915112777983 0.0786052156583915 0.414898833953423 GO:0140311 protein sequestering activity 6/1721 33/18639 0.181818181818182 1.96915112777983 0.0786052156583915 0.414898833953423 GO:0031490 chromatin DNA binding 17/1721 128/18639 0.1328125 1.43840336287042 0.0807452422374492 0.422520362397687 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 17/1721 128/18639 0.1328125 1.43840336287042 0.0807452422374492 0.422520362397687 GO:0003725 double-stranded RNA binding 11/1721 75/18639 0.146666666666667 1.58844857640906 0.0826218423426463 0.430484620617908 GO:0061980 regulatory RNA binding 9/1721 58/18639 0.155172413793103 1.68056863491555 0.0832525508680361 0.430666812129968 GO:0061135 endopeptidase regulator activity 23/1721 184/18639 0.125 1.35379140034863 0.0833663104205456 0.430666812129968 GO:0004435 phosphatidylinositol phospholipase C activity 5/1721 26/18639 0.192307692307692 2.08275600053636 0.0859003751619388 0.440155101108224 GO:0015171 amino acid transmembrane transporter activity 14/1721 102/18639 0.137254901960784 1.48651604744164 0.0859281375310125 0.440155101108224 GO:0035198 miRNA binding 7/1721 42/18639 0.166666666666667 1.80505520046485 0.087960420833899 0.441341722197418 GO:0042056 chemoattractant activity 7/1721 42/18639 0.166666666666667 1.80505520046485 0.087960420833899 0.441341722197418 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6/1721 34/18639 0.176470588235294 1.91123491813925 0.0883558759176186 0.441341722197418 GO:0051536 iron-sulfur cluster binding 11/1721 76/18639 0.144736842105263 1.56754793724579 0.088957643453784 0.441341722197418 GO:0042562 hormone binding 13/1721 94/18639 0.138297872340426 1.49781176208785 0.0911566505449994 0.441341722197418 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 4/1721 19/18639 0.210526315789474 2.28006972690296 0.0917043272629464 0.441341722197418 GO:0008381 mechanosensitive monoatomic ion channel activity 4/1721 19/18639 0.210526315789474 2.28006972690296 0.0917043272629464 0.441341722197418 GO:0015245 fatty acid transmembrane transporter activity 4/1721 19/18639 0.210526315789474 2.28006972690296 0.0917043272629464 0.441341722197418 GO:0050145 nucleoside monophosphate kinase activity 4/1721 19/18639 0.210526315789474 2.28006972690296 0.0917043272629464 0.441341722197418 GO:0005527 macrolide binding 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0010853 cyclase activator activity 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0017166 vinculin binding 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0043047 single-stranded telomeric DNA binding 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0045295 gamma-catenin binding 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/1721 12/18639 0.25 2.70758280069727 0.0919764874101704 0.441341722197418 GO:0031406 carboxylic acid binding 23/1721 187/18639 0.122994652406417 1.33207282173342 0.0954687852312445 0.456295690042247 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 16/1721 122/18639 0.131147540983607 1.42037130528381 0.0960947789390297 0.457486516203851 GO:0050660 flavin adenine dinucleotide binding 12/1721 86/18639 0.13953488372093 1.51120900504034 0.0966799317847221 0.458474364010362 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/1721 60/18639 0.15 1.62454968041836 0.0983277635135299 0.462678695925847 GO:0005154 epidermal growth factor receptor binding 6/1721 35/18639 0.171428571428571 1.85662820619241 0.0987339058511068 0.462678695925847 GO:0005343 organic acid:sodium symporter activity 6/1721 35/18639 0.171428571428571 1.85662820619241 0.0987339058511068 0.462678695925847 GO:0030414 peptidase inhibitor activity 21/1721 169/18639 0.124260355029586 1.34578080034657 0.0990909892427679 0.462678695925847 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 17/1721 132/18639 0.128787878787879 1.39481538217738 0.100363487637467 0.466824804566607 GO:0030159 signaling receptor complex adaptor activity 8/1721 52/18639 0.153846153846154 1.66620480042909 0.10281229631314 0.476389800473861 GO:0043177 organic acid binding 23/1721 189/18639 0.121693121693122 1.31797681303782 0.104139276644998 0.480703733258659 GO:0004866 endopeptidase inhibitor activity 20/1721 161/18639 0.124223602484472 1.34538275811044 0.105676089562368 0.481296492432286 GO:0015026 coreceptor activity 9/1721 61/18639 0.147540983606557 1.59791771844429 0.106417160731222 0.481296492432286 GO:0033218 amide binding 29/1721 247/18639 0.117408906882591 1.27157734769588 0.106429015990329 0.481296492432286 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/1721 20/18639 0.2 2.16606624055782 0.106646422128735 0.481296492432286 GO:0042288 MHC class I protein binding 4/1721 20/18639 0.2 2.16606624055782 0.106646422128735 0.481296492432286 GO:0052745 inositol phosphate phosphatase activity 4/1721 20/18639 0.2 2.16606624055782 0.106646422128735 0.481296492432286 GO:0004497 monooxygenase activity 14/1721 106/18639 0.132075471698113 1.43042110225516 0.109214250289331 0.491059629078695 GO:0004869 cysteine-type endopeptidase inhibitor activity 6/1721 36/18639 0.166666666666667 1.80505520046485 0.109725465308094 0.491537693298989 GO:0005172 vascular endothelial growth factor receptor binding 3/1721 13/18639 0.230769230769231 2.49930720064363 0.111691082724188 0.491934746182805 GO:0019104 DNA N-glycosylase activity 3/1721 13/18639 0.230769230769231 2.49930720064363 0.111691082724188 0.491934746182805 GO:0045159 myosin II binding 3/1721 13/18639 0.230769230769231 2.49930720064363 0.111691082724188 0.491934746182805 GO:0140410 monoatomic cation:bicarbonate symporter activity 3/1721 13/18639 0.230769230769231 2.49930720064363 0.111691082724188 0.491934746182805 GO:0004864 protein phosphatase inhibitor activity 8/1721 53/18639 0.150943396226415 1.6347669740059 0.111840189412236 0.491934746182805 GO:0015294 solute:monoatomic cation symporter activity 15/1721 116/18639 0.129310344827586 1.40047386242962 0.114313470175815 0.50099838553588 GO:0004725 protein tyrosine phosphatase activity 13/1721 98/18639 0.13265306122449 1.43667658812508 0.116538666408589 0.508913456906573 GO:0019208 phosphatase regulator activity 15/1721 117/18639 0.128205128205128 1.38850400035757 0.120558187824524 0.524579354906711 GO:0050661 NADP binding 8/1721 54/18639 0.148148148148148 1.60449351152431 0.121283207455077 0.525849335180228 GO:0008373 sialyltransferase activity 4/1721 21/18639 0.19047619047619 2.06292022910268 0.122604269578783 0.527807032867525 GO:0015174 basic amino acid transmembrane transporter activity 4/1721 21/18639 0.19047619047619 2.06292022910268 0.122604269578783 0.527807032867525 GO:1901682 sulfur compound transmembrane transporter activity 9/1721 63/18639 0.142857142857143 1.54719017182701 0.123679949045326 0.52782241086034 GO:0005416 amino acid:monoatomic cation symporter activity 5/1721 29/18639 0.172413793103448 1.8672984832395 0.123912180473803 0.52782241086034 GO:0106222 lncRNA binding 5/1721 29/18639 0.172413793103448 1.8672984832395 0.123912180473803 0.52782241086034 GO:0030971 receptor tyrosine kinase binding 11/1721 81/18639 0.135802469135802 1.47078571889728 0.124932105396656 0.530306209620771 GO:0015293 symporter activity 18/1721 146/18639 0.123287671232877 1.33524631267263 0.126176602680748 0.53372263294226 GO:0004721 phosphoprotein phosphatase activity 21/1721 175/18639 0.12 1.29963974433469 0.128886783458824 0.541564884011163 GO:0004620 phospholipase activity 14/1721 109/18639 0.128440366972477 1.3910517141197 0.128922777165755 0.541564884011163 GO:0140313 molecular sequestering activity 8/1721 55/18639 0.145454545454545 1.57532090222387 0.131132628943027 0.548948315644256 GO:0046030 inositol trisphosphate phosphatase activity 3/1721 14/18639 0.214285714285714 2.32078525774052 0.132841121811302 0.552291513283974 GO:0098847 sequence-specific single stranded DNA binding 3/1721 14/18639 0.214285714285714 2.32078525774052 0.132841121811302 0.552291513283974 GO:0043531 ADP binding 6/1721 38/18639 0.157894736842105 1.71005229517722 0.133476094115352 0.553037468450639 GO:0042578 phosphoric ester hydrolase activity 40/1721 363/18639 0.110192837465565 1.19342492592717 0.137433733737188 0.558940045496876 GO:0035591 signaling adaptor activity 16/1721 129/18639 0.124031007751938 1.34329689336919 0.137711604265379 0.558940045496876 GO:0001968 fibronectin binding 5/1721 30/18639 0.166666666666667 1.80505520046485 0.138055257706197 0.558940045496876 GO:0098918 structural constituent of synapse 5/1721 30/18639 0.166666666666667 1.80505520046485 0.138055257706197 0.558940045496876 GO:0001784 phosphotyrosine residue binding 7/1721 47/18639 0.148936170212766 1.61302805147922 0.138733276027504 0.558940045496876 GO:0043495 protein-membrane adaptor activity 7/1721 47/18639 0.148936170212766 1.61302805147922 0.138733276027504 0.558940045496876 GO:0061749 forked DNA-dependent helicase activity 7/1721 47/18639 0.148936170212766 1.61302805147922 0.138733276027504 0.558940045496876 GO:1990518 single-stranded 3'-5' DNA helicase activity 7/1721 47/18639 0.148936170212766 1.61302805147922 0.138733276027504 0.558940045496876 GO:0034062 5'-3' RNA polymerase activity 4/1721 22/18639 0.181818181818182 1.96915112777983 0.139504805424673 0.558940045496876 GO:0097747 RNA polymerase activity 4/1721 22/18639 0.181818181818182 1.96915112777983 0.139504805424673 0.558940045496876 GO:0030295 protein kinase activator activity 17/1721 139/18639 0.122302158273381 1.32457288091665 0.14125466567141 0.564089355674642 GO:0061134 peptidase regulator activity 26/1721 226/18639 0.115044247787611 1.24596730651556 0.142687813446479 0.56794428040664 GO:0051219 phosphoprotein binding 12/1721 93/18639 0.129032258064516 1.39746209068246 0.147897797995611 0.586713969808008 GO:0004860 protein kinase inhibitor activity 11/1721 84/18639 0.130952380952381 1.41825765750809 0.149862892561614 0.586713969808008 GO:0009378 four-way junction helicase activity 7/1721 48/18639 0.145833333333333 1.57942330040674 0.150303166894803 0.586713969808008 GO:0036121 double-stranded DNA helicase activity 7/1721 48/18639 0.145833333333333 1.57942330040674 0.150303166894803 0.586713969808008 GO:0043138 3'-5' DNA helicase activity 7/1721 48/18639 0.145833333333333 1.57942330040674 0.150303166894803 0.586713969808008 GO:0140693 molecular condensate scaffold activity 7/1721 48/18639 0.145833333333333 1.57942330040674 0.150303166894803 0.586713969808008 GO:0001664 G protein-coupled receptor binding 33/1721 297/18639 0.111111111111111 1.20337013364323 0.152538785826349 0.590788348509036 GO:0000774 adenyl-nucleotide exchange factor activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0004559 alpha-mannosidase activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0048531 beta-1,3-galactosyltransferase activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0140161 monocarboxylate:sodium symporter activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0140776 protein-containing complex destabilizing activity 3/1721 15/18639 0.2 2.16606624055782 0.1552401014616 0.590788348509036 GO:0016493 C-C chemokine receptor activity 4/1721 23/18639 0.173913043478261 1.88353586135462 0.157269042490123 0.59293359497829 GO:0017134 fibroblast growth factor binding 4/1721 23/18639 0.173913043478261 1.88353586135462 0.157269042490123 0.59293359497829 GO:0043274 phospholipase binding 4/1721 23/18639 0.173913043478261 1.88353586135462 0.157269042490123 0.59293359497829 GO:0017022 myosin binding 10/1721 76/18639 0.131578947368421 1.42504357931435 0.160819495158229 0.604442313071485 GO:0030246 carbohydrate binding 31/1721 280/18639 0.110714285714286 1.19907238316593 0.166204840723783 0.622755174810717 GO:0043425 bHLH transcription factor binding 5/1721 32/18639 0.15625 1.69223925043579 0.168309637038788 0.626772697438921 GO:0051059 NF-kappaB binding 5/1721 32/18639 0.15625 1.69223925043579 0.168309637038788 0.626772697438921 GO:0019957 C-C chemokine binding 4/1721 24/18639 0.166666666666667 1.80505520046485 0.175813709362405 0.651480404810444 GO:0008081 phosphoric diester hydrolase activity 11/1721 87/18639 0.126436781609195 1.3693522210423 0.177146523270827 0.651480404810444 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/1721 16/18639 0.1875 2.03068710052295 0.178700967711596 0.651480404810444 GO:0008142 oxysterol binding 3/1721 16/18639 0.1875 2.03068710052295 0.178700967711596 0.651480404810444 GO:0015378 sodium:chloride symporter activity 3/1721 16/18639 0.1875 2.03068710052295 0.178700967711596 0.651480404810444 GO:0015923 mannosidase activity 3/1721 16/18639 0.1875 2.03068710052295 0.178700967711596 0.651480404810444 GO:0097027 ubiquitin-protein transferase activator activity 3/1721 16/18639 0.1875 2.03068710052295 0.178700967711596 0.651480404810444 GO:0140713 histone chaperone activity 19/1721 164/18639 0.115853658536585 1.25473349300605 0.179546893874774 0.652604578335255 GO:0003714 transcription corepressor activity 23/1721 204/18639 0.112745098039216 1.22106675325563 0.184437163088127 0.665690435375729 GO:0004386 helicase activity 18/1721 155/18639 0.116129032258065 1.25771588161422 0.184764648618754 0.665690435375729 GO:0001098 basal transcription machinery binding 8/1721 60/18639 0.133333333333333 1.44404416037188 0.18606443070997 0.665690435375729 GO:0001099 basal RNA polymerase II transcription machinery binding 8/1721 60/18639 0.133333333333333 1.44404416037188 0.18606443070997 0.665690435375729 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 8/1721 60/18639 0.133333333333333 1.44404416037188 0.18606443070997 0.665690435375729 GO:0019888 protein phosphatase regulator activity 13/1721 107/18639 0.121495327102804 1.31583463211456 0.186857409061568 0.665690435375729 GO:0008307 structural constituent of muscle 6/1721 42/18639 0.142857142857143 1.54719017182701 0.187366831449536 0.665690435375729 GO:0016597 amino acid binding 7/1721 51/18639 0.137254901960784 1.48651604744164 0.187533878829077 0.665690435375729 GO:0015370 solute:sodium symporter activity 10/1721 79/18639 0.126582278481013 1.37092800035305 0.190837937663217 0.675443895985847 GO:0042626 ATPase-coupled transmembrane transporter activity 12/1721 98/18639 0.122448979591837 1.32616300442315 0.191694736179361 0.676504098028326 GO:0097110 scaffold protein binding 9/1721 70/18639 0.128571428571429 1.39247115464431 0.194687574703031 0.676554370590883 GO:0015645 fatty acid ligase activity 4/1721 25/18639 0.16 1.73285299244625 0.195052742756844 0.676554370590883 GO:0015662 P-type ion transporter activity 4/1721 25/18639 0.16 1.73285299244625 0.195052742756844 0.676554370590883 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/1721 25/18639 0.16 1.73285299244625 0.195052742756844 0.676554370590883 GO:0120515 fatty acid-CoA ligase activity 4/1721 25/18639 0.16 1.73285299244625 0.195052742756844 0.676554370590883 GO:0140358 P-type transmembrane transporter activity 4/1721 25/18639 0.16 1.73285299244625 0.195052742756844 0.676554370590883 GO:0003727 single-stranded RNA binding 11/1721 89/18639 0.123595505617978 1.33858026101887 0.196549659113704 0.679804234085575 GO:0016836 hydro-lyase activity 8/1721 61/18639 0.131147540983607 1.42037130528381 0.198086660140724 0.683173879008067 GO:0005080 protein kinase C binding 7/1721 52/18639 0.134615384615385 1.45792920037545 0.200712791664889 0.683517204174466 GO:0015291 secondary active transmembrane transporter activity 31/1721 287/18639 0.10801393728223 1.16982671528384 0.20293087518544 0.683517204174466 GO:0004659 prenyltransferase activity 3/1721 17/18639 0.176470588235294 1.91123491813925 0.203039899996938 0.683517204174466 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1721 17/18639 0.176470588235294 1.91123491813925 0.203039899996938 0.683517204174466 GO:0017110 nucleoside diphosphate phosphatase activity 3/1721 17/18639 0.176470588235294 1.91123491813925 0.203039899996938 0.683517204174466 GO:0046965 nuclear retinoid X receptor binding 3/1721 17/18639 0.176470588235294 1.91123491813925 0.203039899996938 0.683517204174466 GO:0070402 NADPH binding 3/1721 17/18639 0.176470588235294 1.91123491813925 0.203039899996938 0.683517204174466 GO:0070492 oligosaccharide binding 3/1721 17/18639 0.176470588235294 1.91123491813925 0.203039899996938 0.683517204174466 GO:0019209 kinase activator activity 17/1721 148/18639 0.114864864864865 1.2440245300501 0.205516847186537 0.683517204174466 GO:0140299 molecular sensor activity 9/1721 71/18639 0.126760563380282 1.37285888486059 0.206035668642522 0.683517204174466 GO:0019210 kinase inhibitor activity 11/1721 90/18639 0.122222222222222 1.32370714700755 0.206590411680856 0.683517204174466 GO:0140658 ATP-dependent chromatin remodeler activity 18/1721 158/18639 0.113924050632911 1.23383520031774 0.206901906942749 0.683517204174466 GO:0140597 protein carrier chaperone 21/1721 188/18639 0.111702127659574 1.20977103860942 0.209451207589196 0.683517204174466 GO:0033192 calmodulin-dependent protein phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0140791 histone H2AXS140 phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:1990439 MAP kinase serine/threonine phosphatase activity 10/1721 81/18639 0.123456790123457 1.33707792627026 0.212126648205319 0.683517204174466 GO:0005003 ephrin receptor activity 7/1721 53/18639 0.132075471698113 1.43042110225516 0.214236883312032 0.683517204174466 GO:0005005 transmembrane-ephrin receptor activity 7/1721 53/18639 0.132075471698113 1.43042110225516 0.214236883312032 0.683517204174466 GO:0005544 calcium-dependent phospholipid binding 7/1721 53/18639 0.132075471698113 1.43042110225516 0.214236883312032 0.683517204174466 GO:0001637 G protein-coupled chemoattractant receptor activity 4/1721 26/18639 0.153846153846154 1.66620480042909 0.2148986277741 0.683517204174466 GO:0004529 DNA exonuclease activity 4/1721 26/18639 0.153846153846154 1.66620480042909 0.2148986277741 0.683517204174466 GO:0004950 chemokine receptor activity 4/1721 26/18639 0.153846153846154 1.66620480042909 0.2148986277741 0.683517204174466 GO:0016298 lipase activity 15/1721 130/18639 0.115384615384615 1.24965360032182 0.218606260835299 0.683517204174466 GO:0004713 protein tyrosine kinase activity 16/1721 140/18639 0.114285714285714 1.23775213746161 0.220193302396009 0.683517204174466 GO:0003689 DNA clamp loader activity 18/1721 160/18639 0.1125 1.21841226031377 0.222315860744458 0.683517204174466 GO:0003712 transcription coregulator activity 51/1721 495/18639 0.103030303030303 1.1158523057419 0.22261747958732 0.683517204174466 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 10/1721 82/18639 0.121951219512195 1.32077209790111 0.223120457873338 0.683517204174466 GO:0033549 MAP kinase phosphatase activity 10/1721 82/18639 0.121951219512195 1.32077209790111 0.223120457873338 0.683517204174466 GO:0005085 guanyl-nucleotide exchange factor activity 25/1721 230/18639 0.108695652173913 1.17720991334664 0.223158572590956 0.683517204174466 GO:0019902 phosphatase binding 21/1721 190/18639 0.110526315789474 1.19703660662406 0.223623928863041 0.683517204174466 GO:0015373 monoatomic anion:sodium symporter activity 3/1721 18/18639 0.166666666666667 1.80505520046485 0.228079209390753 0.683517204174466 GO:0034185 apolipoprotein binding 3/1721 18/18639 0.166666666666667 1.80505520046485 0.228079209390753 0.683517204174466 GO:0099602 neurotransmitter receptor regulator activity 3/1721 18/18639 0.166666666666667 1.80505520046485 0.228079209390753 0.683517204174466 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 20/1721 181/18639 0.110497237569061 1.1967216798662 0.230832562641639 0.683517204174466 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 10/1721 83/18639 0.120481927710843 1.30485918105892 0.234331041811852 0.683517204174466 GO:0004090 carbonyl reductase (NADPH) activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0004935 adrenergic receptor activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0004955 prostaglandin receptor activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0005337 nucleoside transmembrane transporter activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0015203 polyamine transmembrane transporter activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0016868 intramolecular phosphotransferase activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0031419 cobalamin binding 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0043121 neurotrophin binding 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0043208 glycosphingolipid binding 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0051880 G-quadruplex DNA binding 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0097177 mitochondrial ribosome binding 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0140135 mechanosensitive monoatomic cation channel activity 2/1721 10/18639 0.2 2.16606624055782 0.234340291984641 0.683517204174466 GO:0005385 zinc ion transmembrane transporter activity 4/1721 27/18639 0.148148148148148 1.60449351152431 0.235263585189418 0.683517204174466 GO:0008320 protein transmembrane transporter activity 4/1721 27/18639 0.148148148148148 1.60449351152431 0.235263585189418 0.683517204174466 GO:0016405 CoA-ligase activity 4/1721 27/18639 0.148148148148148 1.60449351152431 0.235263585189418 0.683517204174466 GO:0023026 MHC class II protein complex binding 4/1721 27/18639 0.148148148148148 1.60449351152431 0.235263585189418 0.683517204174466 GO:0035255 ionotropic glutamate receptor binding 4/1721 27/18639 0.148148148148148 1.60449351152431 0.235263585189418 0.683517204174466 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/1721 36/18639 0.138888888888889 1.50421266705404 0.235346121371439 0.683517204174466 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/1721 36/18639 0.138888888888889 1.50421266705404 0.235346121371439 0.683517204174466 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/1721 36/18639 0.138888888888889 1.50421266705404 0.235346121371439 0.683517204174466 GO:0031267 small GTPase binding 30/1721 283/18639 0.106007067137809 1.14809164693877 0.238437267309335 0.690842106237549 GO:0016791 phosphatase activity 29/1721 273/18639 0.106227106227106 1.15047474315342 0.239453926831019 0.692135874221088 GO:0017018 myosin phosphatase activity 10/1721 84/18639 0.119047619047619 1.28932514318918 0.245745656575397 0.708634743663973 GO:0030291 protein serine/threonine kinase inhibitor activity 6/1721 46/18639 0.130434782608696 1.41265189601597 0.248148372500396 0.713867592927679 GO:1901681 sulfur compound binding 29/1721 275/18639 0.105454545454545 1.1421076541123 0.251994966384928 0.716117424987712 GO:0023023 MHC protein complex binding 5/1721 37/18639 0.135135135135135 1.46355827064717 0.253163778628851 0.716117424987712 GO:0042805 actinin binding 5/1721 37/18639 0.135135135135135 1.46355827064717 0.253163778628851 0.716117424987712 GO:0043394 proteoglycan binding 5/1721 37/18639 0.135135135135135 1.46355827064717 0.253163778628851 0.716117424987712 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1721 19/18639 0.157894736842105 1.71005229517722 0.253649499789717 0.716117424987712 GO:0022840 leak channel activity 3/1721 19/18639 0.157894736842105 1.71005229517722 0.253649499789717 0.716117424987712 GO:0022842 narrow pore channel activity 3/1721 19/18639 0.157894736842105 1.71005229517722 0.253649499789717 0.716117424987712 GO:0034987 immunoglobulin receptor binding 3/1721 19/18639 0.157894736842105 1.71005229517722 0.253649499789717 0.716117424987712 GO:0016866 intramolecular transferase activity 4/1721 28/18639 0.142857142857143 1.54719017182701 0.25606060861373 0.71791588650593 GO:0051393 alpha-actinin binding 4/1721 28/18639 0.142857142857143 1.54719017182701 0.25606060861373 0.71791588650593 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/1721 28/18639 0.142857142857143 1.54719017182701 0.25606060861373 0.71791588650593 GO:0140359 ABC-type transporter activity 6/1721 47/18639 0.127659574468085 1.38259547269648 0.264160337837892 0.733532533200107 GO:0002162 dystroglycan binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0004954 prostanoid receptor activity 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0008199 ferric iron binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0015217 ADP transmembrane transporter activity 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0032050 clathrin heavy chain binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0032794 GTPase activating protein binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0034713 type I transforming growth factor beta receptor binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0042608 T cell receptor binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0050998 nitric-oxide synthase binding 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/1721 11/18639 0.181818181818182 1.96915112777983 0.269998480290823 0.733532533200107 GO:0004896 cytokine receptor activity 11/1721 96/18639 0.114583333333333 1.24097545031958 0.270964068151729 0.733532533200107 GO:0016407 acetyltransferase activity 11/1721 96/18639 0.114583333333333 1.24097545031958 0.270964068151729 0.733532533200107 GO:0042887 amide transmembrane transporter activity 5/1721 38/18639 0.131578947368421 1.42504357931435 0.271298276282412 0.733532533200107 GO:0035250 UDP-galactosyltransferase activity 4/1721 29/18639 0.137931034482759 1.4938387865916 0.277204357116118 0.744350307727228 GO:0051861 glycolipid binding 4/1721 29/18639 0.137931034482759 1.4938387865916 0.277204357116118 0.744350307727228 GO:0000339 RNA cap binding 3/1721 20/18639 0.15 1.62454968041836 0.279591219376949 0.744350307727228 GO:0005326 neurotransmitter transmembrane transporter activity 3/1721 20/18639 0.15 1.62454968041836 0.279591219376949 0.744350307727228 GO:0010851 cyclase regulator activity 3/1721 20/18639 0.15 1.62454968041836 0.279591219376949 0.744350307727228 GO:0015095 magnesium ion transmembrane transporter activity 3/1721 20/18639 0.15 1.62454968041836 0.279591219376949 0.744350307727228 GO:0140664 ATP-dependent DNA damage sensor activity 3/1721 20/18639 0.15 1.62454968041836 0.279591219376949 0.744350307727228 GO:0016922 nuclear receptor binding 15/1721 137/18639 0.109489051094891 1.18580268643676 0.282401643393197 0.750187297766611 GO:0005319 lipid transporter activity 19/1721 178/18639 0.106741573033708 1.15604658906176 0.287167764947377 0.75907450545217 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/1721 39/18639 0.128205128205128 1.38850400035757 0.289696461277928 0.75907450545217 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/1721 39/18639 0.128205128205128 1.38850400035757 0.289696461277928 0.75907450545217 GO:0019199 transmembrane receptor protein kinase activity 9/1721 78/18639 0.115384615384615 1.24965360032182 0.291931622302718 0.75907450545217 GO:0030695 GTPase regulator activity 49/1721 489/18639 0.100204498977505 1.08524791193592 0.292975049872114 0.75907450545217 GO:0035254 glutamate receptor binding 6/1721 49/18639 0.122448979591837 1.32616300442315 0.296907343846986 0.75907450545217 GO:0060590 ATPase regulator activity 6/1721 49/18639 0.122448979591837 1.32616300442315 0.296907343846986 0.75907450545217 GO:0060589 nucleoside-triphosphatase regulator activity 49/1721 490/18639 0.1 1.08303312027891 0.298095474759879 0.75907450545217 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/1721 30/18639 0.133333333333333 1.44404416037188 0.29861191087149 0.75907450545217 GO:0008187 poly-pyrimidine tract binding 4/1721 30/18639 0.133333333333333 1.44404416037188 0.29861191087149 0.75907450545217 GO:0004879 nuclear receptor activity 7/1721 59/18639 0.11864406779661 1.28495454948345 0.301176576095825 0.75907450545217 GO:0005049 nuclear export signal receptor activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0005095 GTPase inhibitor activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0008179 adenylate cyclase binding 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0008504 monoamine transmembrane transporter activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0015132 prostaglandin transmembrane transporter activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0015269 calcium-activated potassium channel activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0016208 AMP binding 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0016423 tRNA (guanine) methyltransferase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0016801 hydrolase activity, acting on ether bonds 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0016803 ether hydrolase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0016840 carbon-nitrogen lyase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0031543 peptidyl-proline dioxygenase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0035197 siRNA binding 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0070008 serine-type exopeptidase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0097677 STAT family protein binding 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/1721 12/18639 0.166666666666667 1.80505520046485 0.305602878866953 0.75907450545217 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/1721 21/18639 0.142857142857143 1.54719017182701 0.305755711009976 0.75907450545217 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1721 21/18639 0.142857142857143 1.54719017182701 0.305755711009976 0.75907450545217 GO:0061891 calcium ion sensor activity 3/1721 21/18639 0.142857142857143 1.54719017182701 0.305755711009976 0.75907450545217 GO:0072542 protein phosphatase activator activity 3/1721 21/18639 0.142857142857143 1.54719017182701 0.305755711009976 0.75907450545217 GO:0005539 glycosaminoglycan binding 25/1721 242/18639 0.103305785123967 1.11883586805672 0.307027370279803 0.760675974529961 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1721 40/18639 0.125 1.35379140034863 0.308305928655973 0.760738612577949 GO:0050997 quaternary ammonium group binding 5/1721 40/18639 0.125 1.35379140034863 0.308305928655973 0.760738612577949 GO:0005007 fibroblast growth factor receptor activity 6/1721 50/18639 0.12 1.29963974433469 0.313568674811969 0.76748461939865 GO:0005017 platelet-derived growth factor receptor activity 6/1721 50/18639 0.12 1.29963974433469 0.313568674811969 0.76748461939865 GO:0005019 platelet-derived growth factor beta-receptor activity 6/1721 50/18639 0.12 1.29963974433469 0.313568674811969 0.76748461939865 GO:0048020 CCR chemokine receptor binding 6/1721 50/18639 0.12 1.29963974433469 0.313568674811969 0.76748461939865 GO:0098531 ligand-modulated transcription factor activity 7/1721 60/18639 0.116666666666667 1.26353864032539 0.316380066995843 0.768235031768938 GO:0000510 H3-H4 histone complex chaperone activity 16/1721 151/18639 0.105960264900662 1.14758476320944 0.319218906124123 0.768235031768938 GO:0140584 chromatin extrusion motor activity 16/1721 151/18639 0.105960264900662 1.14758476320944 0.319218906124123 0.768235031768938 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 16/1721 151/18639 0.105960264900662 1.14758476320944 0.319218906124123 0.768235031768938 GO:0140849 ATP-dependent H2AZ histone chaperone activity 16/1721 151/18639 0.105960264900662 1.14758476320944 0.319218906124123 0.768235031768938 GO:0008327 methyl-CpG binding 4/1721 31/18639 0.129032258064516 1.39746209068246 0.32020339874389 0.768235031768938 GO:0016878 acid-thiol ligase activity 4/1721 31/18639 0.129032258064516 1.39746209068246 0.32020339874389 0.768235031768938 GO:0017147 Wnt-protein binding 4/1721 31/18639 0.129032258064516 1.39746209068246 0.32020339874389 0.768235031768938 GO:0070325 lipoprotein particle receptor binding 4/1721 31/18639 0.129032258064516 1.39746209068246 0.32020339874389 0.768235031768938 GO:0072349 modified amino acid transmembrane transporter activity 4/1721 31/18639 0.129032258064516 1.39746209068246 0.32020339874389 0.768235031768938 GO:0046982 protein heterodimerization activity 37/1721 369/18639 0.100271002710027 1.08596816938535 0.32270703301863 0.772714670778336 GO:0008201 heparin binding 18/1721 172/18639 0.104651162790698 1.13340675378025 0.323859134906467 0.773946830268605 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/1721 41/18639 0.121951219512195 1.32077209790111 0.327075374907177 0.775666990842484 GO:0042169 SH2 domain binding 5/1721 41/18639 0.121951219512195 1.32077209790111 0.327075374907177 0.775666990842484 GO:0140318 protein transporter activity 5/1721 41/18639 0.121951219512195 1.32077209790111 0.327075374907177 0.775666990842484 GO:1902936 phosphatidylinositol bisphosphate binding 12/1721 111/18639 0.108108108108108 1.17084661651774 0.327134678180685 0.775666990842484 GO:0015616 DNA translocase activity 16/1721 152/18639 0.105263157894737 1.14003486345148 0.328795004223445 0.776570301804011 GO:0140674 ATP-dependent histone chaperone activity 16/1721 152/18639 0.105263157894737 1.14003486345148 0.328795004223445 0.776570301804011 GO:0015377 chloride:monoatomic cation symporter activity 3/1721 22/18639 0.136363636363636 1.47686334583487 0.332005853997129 0.776599434975944 GO:0016881 acid-amino acid ligase activity 3/1721 22/18639 0.136363636363636 1.47686334583487 0.332005853997129 0.776599434975944 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/1721 22/18639 0.136363636363636 1.47686334583487 0.332005853997129 0.776599434975944 GO:0061133 endopeptidase activator activity 3/1721 22/18639 0.136363636363636 1.47686334583487 0.332005853997129 0.776599434975944 GO:0140784 metal ion sensor activity 3/1721 22/18639 0.136363636363636 1.47686334583487 0.332005853997129 0.776599434975944 GO:0005179 hormone activity 14/1721 132/18639 0.106060606060606 1.1486714912049 0.333695666731291 0.777283977858635 GO:0008236 serine-type peptidase activity 20/1721 194/18639 0.103092783505155 1.11652898997826 0.335959683385535 0.777283977858635 GO:0061775 cohesin loader activity 16/1721 153/18639 0.104575163398693 1.13258365519363 0.338439707762222 0.777283977858635 GO:0031432 titin binding 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:0046974 histone H3K9 methyltransferase activity 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:0070700 BMP receptor binding 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:0071714 icosanoid transmembrane transporter activity 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:0071837 HMG box domain binding 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:1901338 catecholamine binding 2/1721 13/18639 0.153846153846154 1.66620480042909 0.340859569074728 0.777283977858635 GO:0008378 galactosyltransferase activity 4/1721 32/18639 0.125 1.35379140034863 0.341902507558905 0.777283977858635 GO:0022884 macromolecule transmembrane transporter activity 4/1721 32/18639 0.125 1.35379140034863 0.341902507558905 0.777283977858635 GO:0042910 xenobiotic transmembrane transporter activity 4/1721 32/18639 0.125 1.35379140034863 0.341902507558905 0.777283977858635 GO:0070717 poly-purine tract binding 4/1721 32/18639 0.125 1.35379140034863 0.341902507558905 0.777283977858635 GO:0140142 nucleocytoplasmic carrier activity 4/1721 32/18639 0.125 1.35379140034863 0.341902507558905 0.777283977858635 GO:0016859 cis-trans isomerase activity 5/1721 42/18639 0.119047619047619 1.28932514318918 0.345954907806859 0.782568081544655 GO:0048487 beta-tubulin binding 5/1721 42/18639 0.119047619047619 1.28932514318918 0.345954907806859 0.782568081544655 GO:0005518 collagen binding 8/1721 72/18639 0.111111111111111 1.20337013364323 0.346160675279637 0.782568081544655 GO:0019955 cytokine binding 15/1721 144/18639 0.104166666666667 1.12815950029053 0.351338321118597 0.792796880739733 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1721 23/18639 0.130434782608696 1.41265189601597 0.358216375723181 0.800874180714441 GO:0005158 insulin receptor binding 3/1721 23/18639 0.130434782608696 1.41265189601597 0.358216375723181 0.800874180714441 GO:0008171 O-methyltransferase activity 3/1721 23/18639 0.130434782608696 1.41265189601597 0.358216375723181 0.800874180714441 GO:0031681 G-protein beta-subunit binding 3/1721 23/18639 0.130434782608696 1.41265189601597 0.358216375723181 0.800874180714441 GO:0140103 catalytic activity, acting on a glycoprotein 3/1721 23/18639 0.130434782608696 1.41265189601597 0.358216375723181 0.800874180714441 GO:0005246 calcium channel regulator activity 6/1721 53/18639 0.113207547169811 1.22607523050442 0.364270493340461 0.801028868533969 GO:0017046 peptide hormone binding 6/1721 53/18639 0.113207547169811 1.22607523050442 0.364270493340461 0.801028868533969 GO:0140296 general transcription initiation factor binding 6/1721 53/18639 0.113207547169811 1.22607523050442 0.364270493340461 0.801028868533969 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1721 43/18639 0.116279069767442 1.25934083753361 0.364896314011226 0.801028868533969 GO:0008200 ion channel inhibitor activity 5/1721 43/18639 0.116279069767442 1.25934083753361 0.364896314011226 0.801028868533969 GO:0008375 acetylglucosaminyltransferase activity 5/1721 43/18639 0.116279069767442 1.25934083753361 0.364896314011226 0.801028868533969 GO:0015297 antiporter activity 14/1721 135/18639 0.103703703703704 1.12314545806702 0.365121782278739 0.801028868533969 GO:0017171 serine hydrolase activity 20/1721 198/18639 0.101010101010101 1.09397284876657 0.370582767065106 0.801028868533969 GO:0001221 transcription coregulator binding 12/1721 115/18639 0.104347826086957 1.13012151681277 0.372747114386474 0.801028868533969 GO:0035401 histone H3Y41 kinase activity 12/1721 115/18639 0.104347826086957 1.13012151681277 0.372747114386474 0.801028868533969 GO:0140801 histone H2AXY142 kinase activity 12/1721 115/18639 0.104347826086957 1.13012151681277 0.372747114386474 0.801028868533969 GO:0005313 L-glutamate transmembrane transporter activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0005347 ATP transmembrane transporter activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0008191 metalloendopeptidase inhibitor activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0008392 arachidonate epoxygenase activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0008474 palmitoyl-(protein) hydrolase activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0008494 translation activator activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0008559 ABC-type xenobiotic transporter activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0016530 metallochaperone activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0043176 amine binding 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0071933 Arp2/3 complex binding 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0098599 palmitoyl hydrolase activity 2/1721 14/18639 0.142857142857143 1.54719017182701 0.3755293102853 0.801028868533969 GO:0002020 protease binding 14/1721 136/18639 0.102941176470588 1.11488703558123 0.375702387694852 0.801028868533969 GO:0003925 G protein activity 6/1721 54/18639 0.111111111111111 1.20337013364323 0.381294174032848 0.801028868533969 GO:0015485 cholesterol binding 6/1721 54/18639 0.111111111111111 1.20337013364323 0.381294174032848 0.801028868533969 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/1721 54/18639 0.111111111111111 1.20337013364323 0.381294174032848 0.801028868533969 GO:0001223 transcription coactivator binding 5/1721 44/18639 0.113636363636364 1.23071945486239 0.383853286119067 0.801028868533969 GO:0016248 channel inhibitor activity 5/1721 44/18639 0.113636363636364 1.23071945486239 0.383853286119067 0.801028868533969 GO:0016790 thiolester hydrolase activity 5/1721 44/18639 0.113636363636364 1.23071945486239 0.383853286119067 0.801028868533969 GO:0030547 signaling receptor inhibitor activity 5/1721 44/18639 0.113636363636364 1.23071945486239 0.383853286119067 0.801028868533969 GO:0015295 solute:proton symporter activity 3/1721 24/18639 0.125 1.35379140034863 0.384273899489006 0.801028868533969 GO:0030215 semaphorin receptor binding 3/1721 24/18639 0.125 1.35379140034863 0.384273899489006 0.801028868533969 GO:0070300 phosphatidic acid binding 3/1721 24/18639 0.125 1.35379140034863 0.384273899489006 0.801028868533969 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/1721 24/18639 0.125 1.35379140034863 0.384273899489006 0.801028868533969 GO:0070840 dynein complex binding 3/1721 24/18639 0.125 1.35379140034863 0.384273899489006 0.801028868533969 GO:0140612 DNA damage sensor activity 3/1721 24/18639 0.125 1.35379140034863 0.384273899489006 0.801028868533969 GO:0008376 acetylgalactosaminyltransferase activity 4/1721 34/18639 0.117647058823529 1.27415661209283 0.385338434286522 0.801028868533969 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/1721 34/18639 0.117647058823529 1.27415661209283 0.385338434286522 0.801028868533969 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1721 34/18639 0.117647058823529 1.27415661209283 0.385338434286522 0.801028868533969 GO:0042826 histone deacetylase binding 13/1721 127/18639 0.102362204724409 1.10861657981305 0.390978137429888 0.811363177504075 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 34/1721 349/18639 0.0974212034383954 1.05510389941212 0.397021713838802 0.822498908874243 GO:0008509 monoatomic anion transmembrane transporter activity 15/1721 149/18639 0.100671140939597 1.0903017989385 0.402389712779813 0.824227179437906 GO:0008009 chemokine activity 5/1721 45/18639 0.111111111111111 1.20337013364323 0.402781611229529 0.824227179437906 GO:0046915 transition metal ion transmembrane transporter activity 5/1721 45/18639 0.111111111111111 1.20337013364323 0.402781611229529 0.824227179437906 GO:0140303 intramembrane lipid transporter activity 5/1721 45/18639 0.111111111111111 1.20337013364323 0.402781611229529 0.824227179437906 GO:0141110 transporter inhibitor activity 5/1721 45/18639 0.111111111111111 1.20337013364323 0.402781611229529 0.824227179437906 GO:0106310 protein serine kinase activity 35/1721 361/18639 0.0969529085872576 1.05003211107373 0.406256473549826 0.824227179437906 GO:0043015 gamma-tubulin binding 4/1721 35/18639 0.114285714285714 1.23775213746161 0.406943547351969 0.824227179437906 GO:0004953 icosanoid receptor activity 2/1721 15/18639 0.133333333333333 1.44404416037188 0.409419957796638 0.824227179437906 GO:0005041 low-density lipoprotein particle receptor activity 2/1721 15/18639 0.133333333333333 1.44404416037188 0.409419957796638 0.824227179437906 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1721 15/18639 0.133333333333333 1.44404416037188 0.409419957796638 0.824227179437906 GO:0033130 acetylcholine receptor binding 2/1721 15/18639 0.133333333333333 1.44404416037188 0.409419957796638 0.824227179437906 GO:0034483 heparan sulfate sulfotransferase activity 2/1721 15/18639 0.133333333333333 1.44404416037188 0.409419957796638 0.824227179437906 GO:0120283 protein serine/threonine kinase binding 2/1721 15/18639 0.133333333333333 1.44404416037188 0.409419957796638 0.824227179437906 GO:0003707 nuclear steroid receptor activity 3/1721 25/18639 0.12 1.29963974433469 0.410076784497936 0.824227179437906 GO:0004709 MAP kinase kinase kinase activity 3/1721 25/18639 0.12 1.29963974433469 0.410076784497936 0.824227179437906 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1721 25/18639 0.12 1.29963974433469 0.410076784497936 0.824227179437906 GO:0019211 phosphatase activator activity 3/1721 25/18639 0.12 1.29963974433469 0.410076784497936 0.824227179437906 GO:0042974 nuclear retinoic acid receptor binding 3/1721 25/18639 0.12 1.29963974433469 0.410076784497936 0.824227179437906 GO:0005496 steroid binding 11/1721 108/18639 0.101851851851852 1.10308928917296 0.413138168262106 0.82900782854578 GO:0170055 lipid transmembrane transporter activity 6/1721 56/18639 0.107142857142857 1.16039262887026 0.415327562818776 0.832025843666656 GO:0001216 DNA-binding transcription activator activity 47/1721 491/18639 0.0957230142566191 1.03671194812849 0.419351530931722 0.838703061863445 GO:0016500 protein-hormone receptor activity 7/1721 67/18639 0.104477611940299 1.1315271405899 0.424985360756381 0.840452415676073 GO:0042393 histone binding 24/1721 247/18639 0.097165991902834 1.05233987395521 0.42777258682131 0.840452415676073 GO:0004033 aldo-keto reductase (NADPH) activity 4/1721 36/18639 0.111111111111111 1.20337013364323 0.428393225599536 0.840452415676073 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1721 36/18639 0.111111111111111 1.20337013364323 0.428393225599536 0.840452415676073 GO:0045505 dynein intermediate chain binding 4/1721 36/18639 0.111111111111111 1.20337013364323 0.428393225599536 0.840452415676073 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/1721 57/18639 0.105263157894737 1.14003486345148 0.432275314991307 0.840452415676073 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0008143 poly(A) binding 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0015216 purine nucleotide transmembrane transporter activity 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0050681 nuclear androgen receptor binding 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0050750 low-density lipoprotein particle receptor binding 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0070006 metalloaminopeptidase activity 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0097602 cullin family protein binding 3/1721 26/18639 0.115384615384615 1.24965360032182 0.435534804940176 0.840452415676073 GO:0005504 fatty acid binding 5/1721 47/18639 0.106382978723404 1.15216289391373 0.440386821535355 0.840452415676073 GO:0005548 phospholipid transporter activity 7/1721 68/18639 0.102941176470588 1.11488703558123 0.440506866068531 0.840452415676073 GO:0032934 sterol binding 7/1721 68/18639 0.102941176470588 1.11488703558123 0.440506866068531 0.840452415676073 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 46/1721 484/18639 0.0950413223140496 1.02932899861218 0.440732778839273 0.840452415676073 GO:0004708 MAP kinase kinase activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0005521 lamin binding 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0008296 3'-5'-DNA exonuclease activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0008391 arachidonate monooxygenase activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0022841 potassium ion leak channel activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0022858 alanine transmembrane transporter activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0030275 LRR domain binding 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0043023 ribosomal large subunit binding 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0070411 I-SMAD binding 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0140327 flippase activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0140328 floppase activity 2/1721 16/18639 0.125 1.35379140034863 0.442379813523073 0.840452415676073 GO:0043130 ubiquitin binding 10/1721 100/18639 0.1 1.08303312027891 0.444776287439476 0.843685020236756 GO:0030551 cyclic nucleotide binding 4/1721 37/18639 0.108108108108108 1.17084661651774 0.44963315856568 0.851567323710975 GO:0008080 N-acetyltransferase activity 7/1721 69/18639 0.101449275362319 1.09872925245686 0.455959270201223 0.856085356727778 GO:0004674 protein serine/threonine kinase activity 41/1721 433/18639 0.0946882217090069 1.02550480211167 0.456641647856801 0.856085356727778 GO:0004252 serine-type endopeptidase activity 17/1721 176/18639 0.0965909090909091 1.04611153663304 0.460124125039695 0.856085356727778 GO:0001671 ATPase activator activity 3/1721 27/18639 0.111111111111111 1.20337013364323 0.460568707409021 0.856085356727778 GO:0008266 poly(U) RNA binding 3/1721 27/18639 0.111111111111111 1.20337013364323 0.460568707409021 0.856085356727778 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/1721 27/18639 0.111111111111111 1.20337013364323 0.460568707409021 0.856085356727778 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1721 27/18639 0.111111111111111 1.20337013364323 0.460568707409021 0.856085356727778 GO:0000049 tRNA binding 8/1721 80/18639 0.1 1.08303312027891 0.46151748916328 0.856085356727778 GO:0001786 phosphatidylserine binding 6/1721 59/18639 0.101694915254237 1.10138961384296 0.465888448353752 0.856085356727778 GO:0036002 pre-mRNA binding 6/1721 59/18639 0.101694915254237 1.10138961384296 0.465888448353752 0.856085356727778 GO:0070063 RNA polymerase binding 6/1721 59/18639 0.101694915254237 1.10138961384296 0.465888448353752 0.856085356727778 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0015278 intracellularly gated calcium channel activity 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0016018 cyclosporin A binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0019198 transmembrane receptor protein phosphatase activity 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0030548 acetylcholine receptor regulator activity 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0031489 myosin V binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0036041 long-chain fatty acid binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0038191 neuropilin binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0045236 CXCR chemokine receptor binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0048038 quinone binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0051787 misfolded protein binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0070403 NAD+ binding 2/1721 17/18639 0.117647058823529 1.27415661209283 0.474291801993224 0.856085356727778 GO:0005004 GPI-linked ephrin receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0005008 hepatocyte growth factor receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0005009 insulin receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0005011 macrophage colony-stimulating factor receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0005018 platelet-derived growth factor alpha-receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0005020 stem cell factor receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0008288 boss receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0016763 pentosyltransferase activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0036332 placental growth factor receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0038062 protein tyrosine kinase collagen receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0060175 brain-derived neurotrophic factor receptor activity 5/1721 49/18639 0.102040816326531 1.10513583701929 0.477405095967632 0.856085356727778 GO:0043178 alcohol binding 9/1721 92/18639 0.0978260869565217 1.05948892201197 0.479576574540853 0.857446187765237 GO:0052689 carboxylic ester hydrolase activity 9/1721 92/18639 0.0978260869565217 1.05948892201197 0.479576574540853 0.857446187765237 GO:0004722 protein serine/threonine phosphatase activity 10/1721 103/18639 0.0970873786407767 1.0514884662902 0.4828656741937 0.862057247751694 GO:0045499 chemorepellent activity 3/1721 28/18639 0.107142857142857 1.16039262887026 0.485109679264455 0.862259371342678 GO:0046625 sphingolipid binding 3/1721 28/18639 0.107142857142857 1.16039262887026 0.485109679264455 0.862259371342678 GO:0051959 dynein light intermediate chain binding 3/1721 28/18639 0.107142857142857 1.16039262887026 0.485109679264455 0.862259371342678 GO:0005201 extracellular matrix structural constituent 16/1721 168/18639 0.0952380952380952 1.03146011455134 0.486911769305841 0.864197204586683 GO:0005006 epidermal growth factor receptor activity 5/1721 50/18639 0.1 1.08303312027891 0.495609142762706 0.87718599219914 GO:0005125 cytokine activity 22/1721 234/18639 0.094017094017094 1.01823626692889 0.497521201507134 0.87718599219914 GO:0042379 chemokine receptor binding 7/1721 72/18639 0.0972222222222222 1.05294886693783 0.501693777832424 0.87718599219914 GO:0008308 voltage-gated monoatomic anion channel activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0008409 5'-3' exonuclease activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0008525 phosphatidylcholine transporter activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0015172 acidic amino acid transmembrane transporter activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0017075 syntaxin-1 binding 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0017128 phospholipid scramblase activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0030228 lipoprotein particle receptor activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0035615 clathrin adaptor activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0070064 proline-rich region binding 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:1901611 phosphatidylglycerol binding 2/1721 18/18639 0.111111111111111 1.20337013364323 0.505068376068533 0.87718599219914 GO:0016410 N-acyltransferase activity 9/1721 94/18639 0.0957446808510638 1.03694660452236 0.506094889084435 0.877713136212148 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1721 29/18639 0.103448275862069 1.1203790899437 0.509098754896957 0.879154891102283 GO:0016417 S-acyltransferase activity 3/1721 29/18639 0.103448275862069 1.1203790899437 0.509098754896957 0.879154891102283 GO:0097472 cyclin-dependent protein kinase activity 3/1721 29/18639 0.103448275862069 1.1203790899437 0.509098754896957 0.879154891102283 GO:0004519 endonuclease activity 12/1721 127/18639 0.094488188976378 1.0233383813659 0.511153425091876 0.880612209756593 GO:0005010 insulin-like growth factor receptor activity 5/1721 51/18639 0.0980392156862745 1.06179717674403 0.513569558902527 0.880612209756593 GO:0005021 vascular endothelial growth factor receptor activity 5/1721 51/18639 0.0980392156862745 1.06179717674403 0.513569558902527 0.880612209756593 GO:0005030 neurotrophin receptor activity 5/1721 51/18639 0.0980392156862745 1.06179717674403 0.513569558902527 0.880612209756593 GO:0016830 carbon-carbon lyase activity 5/1721 51/18639 0.0980392156862745 1.06179717674403 0.513569558902527 0.880612209756593 GO:0004521 RNA endonuclease activity 7/1721 73/18639 0.0958904109589041 1.03852490985649 0.516666901900095 0.884673651490431 GO:0008013 beta-catenin binding 10/1721 106/18639 0.0943396226415094 1.02172935875369 0.520343126565249 0.889713458662271 GO:0001530 lipopolysaccharide binding 4/1721 41/18639 0.0975609756097561 1.05661767832089 0.531572493642339 0.891568049200659 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1721 41/18639 0.0975609756097561 1.05661767832089 0.531572493642339 0.891568049200659 GO:0042287 MHC protein binding 4/1721 41/18639 0.0975609756097561 1.05661767832089 0.531572493642339 0.891568049200659 GO:0001965 G-protein alpha-subunit binding 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0015215 nucleotide transmembrane transporter activity 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0016769 transferase activity, transferring nitrogenous groups 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0031210 phosphatidylcholine binding 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0033612 receptor serine/threonine kinase binding 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0051721 protein phosphatase 2A binding 3/1721 30/18639 0.1 1.08303312027891 0.532486182010897 0.891568049200659 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0016918 retinal binding 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0030506 ankyrin binding 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0031420 alkali metal ion binding 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0043395 heparan sulfate proteoglycan binding 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0046624 sphingolipid transporter activity 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0070003 threonine-type peptidase activity 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0097001 ceramide binding 2/1721 19/18639 0.105263157894737 1.14003486345148 0.534647067395453 0.891568049200659 GO:0008237 metallopeptidase activity 17/1721 184/18639 0.0923913043478261 1.00062842634464 0.536334619558887 0.893155319814114 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/1721 86/18639 0.0930232558139535 1.00747267002689 0.545458948760914 0.906203717368817 GO:1901981 phosphatidylinositol phosphate binding 17/1721 185/18639 0.0918918918918919 0.995219624040077 0.545663029157006 0.906203717368817 GO:0034212 protein N-acetyltransferase activity 5/1721 53/18639 0.0943396226415094 1.02172935875369 0.548654018601944 0.907446837306213 GO:0038064 collagen receptor activity 5/1721 53/18639 0.0943396226415094 1.02172935875369 0.548654018601944 0.907446837306213 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/1721 53/18639 0.0943396226415094 1.02172935875369 0.548654018601944 0.907446837306213 GO:0005164 tumor necrosis factor receptor binding 3/1721 31/18639 0.0967741935483871 1.04809656801185 0.555230765932362 0.914586363421828 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/1721 31/18639 0.0967741935483871 1.04809656801185 0.555230765932362 0.914586363421828 GO:0047499 calcium-independent phospholipase A2 activity 3/1721 31/18639 0.0967741935483871 1.04809656801185 0.555230765932362 0.914586363421828 GO:0032182 ubiquitin-like protein binding 11/1721 120/18639 0.0916666666666667 0.992780360255665 0.55626790347119 0.91505316370464 GO:0015464 acetylcholine receptor activity 2/1721 20/18639 0.1 1.08303312027891 0.562986606064175 0.915645411827981 GO:0016408 C-acyltransferase activity 2/1721 20/18639 0.1 1.08303312027891 0.562986606064175 0.915645411827981 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1721 20/18639 0.1 1.08303312027891 0.562986606064175 0.915645411827981 GO:0030742 GTP-dependent protein binding 2/1721 20/18639 0.1 1.08303312027891 0.562986606064175 0.915645411827981 GO:0031418 L-ascorbic acid binding 2/1721 20/18639 0.1 1.08303312027891 0.562986606064175 0.915645411827981 GO:0061608 nuclear import signal receptor activity 2/1721 20/18639 0.1 1.08303312027891 0.562986606064175 0.915645411827981 GO:0004222 metalloendopeptidase activity 10/1721 110/18639 0.0909090909090909 0.984575563889916 0.568865198589686 0.915645411827981 GO:0015106 bicarbonate transmembrane transporter activity 3/1721 32/18639 0.09375 1.01534355026148 0.577299206453754 0.915645411827981 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1721 32/18639 0.09375 1.01534355026148 0.577299206453754 0.915645411827981 GO:0047498 calcium-dependent phospholipase A2 activity 3/1721 32/18639 0.09375 1.01534355026148 0.577299206453754 0.915645411827981 GO:0071813 lipoprotein particle binding 3/1721 32/18639 0.09375 1.01534355026148 0.577299206453754 0.915645411827981 GO:0071814 protein-lipid complex binding 3/1721 32/18639 0.09375 1.01534355026148 0.577299206453754 0.915645411827981 GO:0016874 ligase activity 15/1721 167/18639 0.0898203592814371 0.972784239771474 0.584166142483476 0.915645411827981 GO:0016757 glycosyltransferase activity 24/1721 267/18639 0.0898876404494382 0.973512917104636 0.58655364473997 0.915645411827981 GO:0001046 core promoter sequence-specific DNA binding 4/1721 44/18639 0.0909090909090909 0.984575563889916 0.588845834417874 0.915645411827981 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/1721 44/18639 0.0909090909090909 0.984575563889916 0.588845834417874 0.915645411827981 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0001846 opsonin binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0009975 cyclase activity 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0035613 RNA stem-loop binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0036122 BMP binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0051010 microtubule plus-end binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0051428 peptide hormone receptor binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0140312 cargo adaptor activity 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:1904047 S-adenosyl-L-methionine binding 2/1721 21/18639 0.0952380952380952 1.03146011455134 0.59006354238567 0.915645411827981 GO:0030296 protein tyrosine kinase activator activity 3/1721 33/18639 0.0909090909090909 0.984575563889916 0.598665438772962 0.915645411827981 GO:0071889 14-3-3 protein binding 3/1721 33/18639 0.0909090909090909 0.984575563889916 0.598665438772962 0.915645411827981 GO:0033293 monocarboxylic acid binding 7/1721 79/18639 0.0886075949367089 0.959649600247133 0.602516576672458 0.915645411827981 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/1721 45/18639 0.0888888888888889 0.962696106914585 0.6069984415582 0.915645411827981 GO:0042605 peptide antigen binding 4/1721 45/18639 0.0888888888888889 0.962696106914585 0.6069984415582 0.915645411827981 GO:0016504 peptidase activator activity 5/1721 57/18639 0.087719298245614 0.950029052876235 0.614876746607353 0.915645411827981 GO:0008093 cytoskeletal anchor activity 2/1721 22/18639 0.0909090909090909 0.984575563889916 0.615869311224523 0.915645411827981 GO:0033691 sialic acid binding 2/1721 22/18639 0.0909090909090909 0.984575563889916 0.615869311224523 0.915645411827981 GO:0035173 histone kinase activity 32/1721 360/18639 0.0888888888888889 0.962696106914585 0.61714971314305 0.915645411827981 GO:0016831 carboxy-lyase activity 3/1721 34/18639 0.0882352941176471 0.955617459069624 0.61930998759423 0.915645411827981 GO:0051427 hormone receptor binding 3/1721 34/18639 0.0882352941176471 0.955617459069624 0.61930998759423 0.915645411827981 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/1721 34/18639 0.0882352941176471 0.955617459069624 0.61930998759423 0.915645411827981 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0008140 cAMP response element binding protein binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0008190 eukaryotic initiation factor 4E binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0008239 dipeptidyl-peptidase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0008401 retinoic acid 4-hydroxylase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0008519 ammonium channel activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0015187 glycine transmembrane transporter activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0015643 toxic substance binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0016783 sulfurtransferase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0019911 structural constituent of myelin sheath 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0032052 bile acid binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0032356 oxidized DNA binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0033204 ribonuclease P RNA binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0035256 G protein-coupled glutamate receptor binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0042975 peroxisome proliferator activated receptor binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0043295 glutathione binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0050308 sugar-phosphatase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0051378 serotonin binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0070097 delta-catenin binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0099122 RNA polymerase II C-terminal domain binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0140940 histone H2A methyltransferase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0140999 histone H3K4 trimethyltransferase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0141109 transporter activator activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:1905394 retromer complex binding 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:1990259 histone H2AQ104 methyltransferase activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:1990757 ubiquitin ligase activator activity 1/1721 10/18639 0.1 1.08303312027891 0.620547495447355 0.915645411827981 GO:0002039 p53 binding 6/1721 69/18639 0.0869565217391304 0.941767930677311 0.622298619177909 0.915645411827981 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/1721 46/18639 0.0869565217391304 0.941767930677311 0.624651690919013 0.915645411827981 GO:0030276 clathrin binding 4/1721 46/18639 0.0869565217391304 0.941767930677311 0.624651690919013 0.915645411827981 GO:0004623 phospholipase A2 activity 3/1721 35/18639 0.0857142857142857 0.928314103096207 0.639219341366942 0.915645411827981 GO:0016229 steroid dehydrogenase activity 3/1721 35/18639 0.0857142857142857 0.928314103096207 0.639219341366942 0.915645411827981 GO:0016849 phosphorus-oxygen lyase activity 2/1721 23/18639 0.0869565217391304 0.941767930677311 0.640407686034175 0.915645411827981 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/1721 23/18639 0.0869565217391304 0.941767930677311 0.640407686034175 0.915645411827981 GO:0005516 calmodulin binding 18/1721 207/18639 0.0869565217391304 0.941767930677311 0.641163495186534 0.915645411827981 GO:0140938 histone H3 methyltransferase activity 4/1721 47/18639 0.0851063829787234 0.921730315130985 0.641792609001214 0.915645411827981 GO:0005126 cytokine receptor binding 24/1721 275/18639 0.0872727272727273 0.945192541334319 0.645500167927742 0.915645411827981 GO:0141003 histone H2AX kinase activity 31/1721 354/18639 0.0875706214689266 0.948418834142546 0.649734539689453 0.915645411827981 GO:0001540 amyloid-beta binding 7/1721 83/18639 0.0843373493975904 0.913401426741247 0.655044145994321 0.915645411827981 GO:0030165 PDZ domain binding 7/1721 83/18639 0.0843373493975904 0.913401426741247 0.655044145994321 0.915645411827981 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0003953 NAD+ nucleosidase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0004016 adenylate cyclase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0005114 type II transforming growth factor beta receptor binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0005225 volume-sensitive anion channel activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0008432 JUN kinase binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0008526 phosphatidylinositol transfer activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0016594 glycine binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0019107 myristoyltransferase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0019203 carbohydrate phosphatase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0031731 CCR6 chemokine receptor binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0032404 mismatch repair complex binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0043522 leucine zipper domain binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0048185 activin binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0048407 platelet-derived growth factor binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0070697 activin receptor binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0140031 phosphorylation-dependent protein binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0140537 transcription regulator activator activity 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:1900750 oligopeptide binding 1/1721 11/18639 0.0909090909090909 0.984575563889916 0.655602396963008 0.915645411827981 GO:0000993 RNA polymerase II complex binding 3/1721 36/18639 0.0833333333333333 0.902527600232423 0.658385351891252 0.915645411827981 GO:0016409 palmitoyltransferase activity 3/1721 36/18639 0.0833333333333333 0.902527600232423 0.658385351891252 0.915645411827981 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1721 60/18639 0.0833333333333333 0.902527600232423 0.660596792430586 0.915645411827981 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0004806 triacylglycerol lipase activity 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0015149 hexose transmembrane transporter activity 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0035035 histone acetyltransferase binding 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0050431 transforming growth factor beta binding 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0055056 D-glucose transmembrane transporter activity 2/1721 24/18639 0.0833333333333333 0.902527600232423 0.6636925757201 0.915645411827981 GO:0140996 histone H3 kinase activity 31/1721 357/18639 0.0868347338935574 0.940448927973281 0.668286991012348 0.915645411827981 GO:0015103 inorganic anion transmembrane transporter activity 14/1721 165/18639 0.0848484848484849 0.918937192963922 0.669910983612014 0.915645411827981 GO:0001222 transcription corepressor binding 4/1721 49/18639 0.0816326530612245 0.884108669615435 0.674500745309752 0.915645411827981 GO:0019905 syntaxin binding 5/1721 61/18639 0.0819672131147541 0.887732065802383 0.675029552226737 0.915645411827981 GO:0030280 structural constituent of skin epidermis 3/1721 37/18639 0.0810810810810811 0.878134962388304 0.676804663067038 0.915645411827981 GO:0001848 complement binding 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0008139 nuclear localization sequence binding 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0008483 transaminase activity 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0015271 outward rectifier potassium channel activity 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0017025 TBP-class protein binding 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0019707 protein-cysteine S-acyltransferase activity 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0047617 fatty acyl-CoA hydrolase activity 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0120020 cholesterol transfer activity 2/1721 25/18639 0.08 0.866426496223126 0.685746122782896 0.915645411827981 GO:0035402 histone H3T11 kinase activity 21/1721 247/18639 0.0850202429149798 0.920797389710812 0.687283172563535 0.915645411827981 GO:0000340 RNA 7-methylguanosine cap binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0003720 telomerase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0003995 acyl-CoA dehydrogenase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0004000 adenosine deaminase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0004032 aldose reductase (NADPH) activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0004126 cytidine deaminase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0004300 enoyl-CoA hydratase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0004526 ribonuclease P activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0004875 complement receptor activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0005078 MAP-kinase scaffold activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0005165 neurotrophin receptor binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0005247 voltage-gated chloride channel activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0015368 calcium:monoatomic cation antiporter activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0034452 dynactin binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0035251 UDP-glucosyltransferase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0035259 nuclear glucocorticoid receptor binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0035497 cAMP response element binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0036009 protein-glutamine N-methyltransferase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0042301 phosphate ion binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:1990459 transferrin receptor binding 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:1990817 poly(A) RNA polymerase activity 1/1721 12/18639 0.0833333333333333 0.902527600232423 0.68742053497174 0.915645411827981 GO:0015605 organophosphate ester transmembrane transporter activity 4/1721 50/18639 0.08 0.866426496223126 0.690056536835582 0.915645411827981 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1721 50/18639 0.08 0.866426496223126 0.690056536835582 0.915645411827981 GO:0140375 immune receptor activity 13/1721 156/18639 0.0833333333333333 0.902527600232423 0.691891195984934 0.915645411827981 GO:0016247 channel regulator activity 14/1721 168/18639 0.0833333333333333 0.902527600232423 0.695857751852431 0.915645411827981 GO:0016741 transferase activity, transferring one-carbon groups 18/1721 215/18639 0.0837209302325581 0.906725403024202 0.703677999115341 0.915645411827981 GO:0005048 signal sequence binding 4/1721 51/18639 0.0784313725490196 0.849437741395222 0.70507670517031 0.915645411827981 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0005160 transforming growth factor beta receptor binding 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0005227 calcium-activated cation channel activity 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0008157 protein phosphatase 1 binding 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0008198 ferrous iron binding 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0015145 monosaccharide transmembrane transporter activity 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0016289 acyl-CoA hydrolase activity 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0034237 protein kinase A regulatory subunit binding 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0043548 phosphatidylinositol 3-kinase binding 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0052742 phosphatidylinositol kinase activity 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0070412 R-SMAD binding 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0120014 phospholipid transfer activity 2/1721 26/18639 0.0769230769230769 0.833102400214544 0.706597065936457 0.915645411827981 GO:0141108 transporter regulator activity 14/1721 170/18639 0.0823529411764706 0.891909628464983 0.712465860659323 0.915645411827981 GO:0003924 GTPase activity 28/1721 331/18639 0.0845921450151057 0.916160947667958 0.715630008937905 0.915645411827981 GO:0003964 RNA-directed DNA polymerase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0004465 lipoprotein lipase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0008035 high-density lipoprotein particle binding 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0008253 5'-nucleotidase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0009982 pseudouridine synthase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0030955 potassium ion binding 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0035325 Toll-like receptor binding 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0046975 histone H3K36 methyltransferase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0097157 pre-mRNA intronic binding 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0140333 glycerophospholipid flippase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0140852 histone ubiquitin ligase activity 1/1721 13/18639 0.0769230769230769 0.833102400214544 0.716300615463157 0.915645411827981 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1721 52/18639 0.0769230769230769 0.833102400214544 0.719561485067214 0.915645411827981 GO:0016779 nucleotidyltransferase activity 11/1721 136/18639 0.0808823529411765 0.875982670813822 0.721025157139168 0.915645411827981 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 19/1721 229/18639 0.0829694323144105 0.898586431672456 0.721640475260733 0.915645411827981 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1721 27/18639 0.0740740740740741 0.802246755762154 0.726279334618651 0.915645411827981 GO:0008395 steroid hydroxylase activity 2/1721 27/18639 0.0740740740740741 0.802246755762154 0.726279334618651 0.915645411827981 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/1721 27/18639 0.0740740740740741 0.802246755762154 0.726279334618651 0.915645411827981 GO:0004177 aminopeptidase activity 3/1721 40/18639 0.075 0.812274840209181 0.72760962481405 0.915645411827981 GO:0071855 neuropeptide receptor binding 3/1721 40/18639 0.075 0.812274840209181 0.72760962481405 0.915645411827981 GO:0016251 RNA polymerase II general transcription initiation factor activity 4/1721 53/18639 0.0754716981132075 0.817383487002949 0.733513114982746 0.915645411827981 GO:0051018 protein kinase A binding 4/1721 53/18639 0.0754716981132075 0.817383487002949 0.733513114982746 0.915645411827981 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 20/1721 243/18639 0.0823045267489712 0.891385284180171 0.73824852345321 0.915645411827981 GO:0004065 arylsulfatase activity 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0005161 platelet-derived growth factor receptor binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0005545 1-phosphatidylinositol binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0030983 mismatched DNA binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0031404 chloride ion binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0032454 histone H3K9 demethylase activity 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0034236 protein kinase A catalytic subunit binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0042043 neurexin family protein binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:1901474 azole transmembrane transporter activity 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:1901612 cardiolipin binding 1/1721 14/18639 0.0714285714285714 0.773595085913505 0.742513792784531 0.915645411827981 GO:0001727 lipid kinase activity 3/1721 41/18639 0.0731707317073171 0.792463258740664 0.743086240432869 0.915645411827981 GO:0008227 G protein-coupled amine receptor activity 3/1721 41/18639 0.0731707317073171 0.792463258740664 0.743086240432869 0.915645411827981 GO:0017080 sodium channel regulator activity 3/1721 41/18639 0.0731707317073171 0.792463258740664 0.743086240432869 0.915645411827981 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1721 41/18639 0.0731707317073171 0.792463258740664 0.743086240432869 0.915645411827981 GO:0050698 proteoglycan sulfotransferase activity 2/1721 28/18639 0.0714285714285714 0.773595085913505 0.744830846568974 0.915645411827981 GO:0051019 mitogen-activated protein kinase binding 2/1721 28/18639 0.0714285714285714 0.773595085913505 0.744830846568974 0.915645411827981 GO:0051119 sugar transmembrane transporter activity 2/1721 28/18639 0.0714285714285714 0.773595085913505 0.744830846568974 0.915645411827981 GO:0005253 monoatomic anion channel activity 8/1721 103/18639 0.0776699029126214 0.841190773032161 0.745708907403569 0.915645411827981 GO:0004175 endopeptidase activity 34/1721 405/18639 0.0839506172839506 0.909212989863774 0.746515055034168 0.915645411827981 GO:0008186 ATP-dependent activity, acting on RNA 6/1721 79/18639 0.0759493670886076 0.822556800211829 0.748837128205605 0.915645411827981 GO:0004676 3-phosphoinositide-dependent protein kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0004711 ribosomal protein S6 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0035175 histone H3S10 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0035979 histone H2AXS139 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0044022 histone H3S28 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0044023 histone H4S1 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0044024 histone H2AS1 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0044025 histone H2BS14 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0072354 histone H3T3 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0072371 histone H2AS121 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0072518 Rho-dependent protein serine/threonine kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0140823 histone H2BS36 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0140855 histone H3S57 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0140995 histone H2A kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0140997 histone H4 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0140998 histone H2B kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:1990244 histone H2AT120 kinase activity 20/1721 245/18639 0.0816326530612245 0.884108669615435 0.751121373048254 0.915645411827981 GO:0042054 histone methyltransferase activity 5/1721 67/18639 0.0746268656716418 0.808233671849931 0.752860639032346 0.915645411827981 GO:0004677 DNA-dependent protein kinase activity 20/1721 246/18639 0.0813008130081301 0.880514731934071 0.757403123615161 0.915645411827981 GO:0140857 histone H3T45 kinase activity 20/1721 246/18639 0.0813008130081301 0.880514731934071 0.757403123615161 0.915645411827981 GO:0019894 kinesin binding 3/1721 42/18639 0.0714285714285714 0.773595085913505 0.757853552244 0.915645411827981 GO:0043175 RNA polymerase core enzyme binding 3/1721 42/18639 0.0714285714285714 0.773595085913505 0.757853552244 0.915645411827981 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/1721 29/18639 0.0689655172413793 0.746919393295798 0.762292482989124 0.915645411827981 GO:0099604 ligand-gated calcium channel activity 2/1721 29/18639 0.0689655172413793 0.746919393295798 0.762292482989124 0.915645411827981 GO:0035403 histone H3T6 kinase activity 20/1721 247/18639 0.0809716599190283 0.876949894962678 0.76358109287081 0.915645411827981 GO:0140223 general transcription initiation factor activity 5/1721 68/18639 0.0735294117647059 0.79634788255802 0.764370663720426 0.915645411827981 GO:0004089 carbonate dehydratase activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0008020 G protein-coupled photoreceptor activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0008242 omega peptidase activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0008252 nucleotidase activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0010181 FMN binding 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0015116 sulfate transmembrane transporter activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0015929 hexosaminidase activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0017081 chloride channel regulator activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0030553 cGMP binding 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0031005 filamin binding 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0045504 dynein heavy chain binding 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0050780 dopamine receptor binding 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0051371 muscle alpha-actinin binding 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0061578 K63-linked deubiquitinase activity 1/1721 15/18639 0.0666666666666667 0.722022080185938 0.766306209569381 0.915645411827981 GO:0004679 AMP-activated protein kinase activity 20/1721 248/18639 0.0806451612903226 0.873413806676538 0.769654903508582 0.918742431523519 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/1721 130/18639 0.0769230769230769 0.833102400214544 0.771501820258768 0.918744259178051 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 10/1721 130/18639 0.0769230769230769 0.833102400214544 0.771501820258768 0.918744259178051 GO:0048156 tau protein binding 3/1721 43/18639 0.0697674418604651 0.755604502520168 0.771926807546632 0.918744259178051 GO:0000149 SNARE binding 8/1721 106/18639 0.0754716981132075 0.817383487002949 0.773680327931386 0.919929400694126 GO:0016279 protein-lysine N-methyltransferase activity 5/1721 69/18639 0.072463768115942 0.784806608897759 0.77547004220031 0.92049714078945 GO:0019001 guanyl nucleotide binding 33/1721 400/18639 0.0825 0.893502324230099 0.77786257353561 0.92049714078945 GO:0032561 guanyl ribonucleotide binding 33/1721 400/18639 0.0825 0.893502324230099 0.77786257353561 0.92049714078945 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1721 30/18639 0.0666666666666667 0.722022080185938 0.778707218773283 0.92049714078945 GO:0022839 monoatomic ion-gated channel activity 2/1721 30/18639 0.0666666666666667 0.722022080185938 0.778707218773283 0.92049714078945 GO:0031624 ubiquitin conjugating enzyme binding 2/1721 30/18639 0.0666666666666667 0.722022080185938 0.778707218773283 0.92049714078945 GO:0008276 protein methyltransferase activity 7/1721 95/18639 0.0736842105263158 0.798024404416037 0.785425490163536 0.92327430637443 GO:0016278 lysine N-methyltransferase activity 5/1721 70/18639 0.0714285714285714 0.773595085913505 0.786163680258467 0.92327430637443 GO:0000062 fatty-acyl-CoA binding 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0015562 efflux transmembrane transporter activity 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0016722 oxidoreductase activity, acting on metal ions 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1721 16/18639 0.0625 0.676895700174317 0.787901302639134 0.92327430637443 GO:0005254 chloride channel activity 6/1721 83/18639 0.072289156626506 0.782915508635355 0.789857482582669 0.924674044219248 GO:0008194 UDP-glycosyltransferase activity 11/1721 145/18639 0.0758620689655172 0.821611332625378 0.79398692429223 0.926920601486261 GO:0005184 neuropeptide hormone activity 2/1721 31/18639 0.0645161290322581 0.698731045341231 0.794119387934726 0.926920601486261 GO:0005452 solute:inorganic anion antiporter activity 2/1721 31/18639 0.0645161290322581 0.698731045341231 0.794119387934726 0.926920601486261 GO:0008408 3'-5' exonuclease activity 4/1721 58/18639 0.0689655172413793 0.746919393295798 0.795468514771445 0.926920601486261 GO:0004540 RNA nuclease activity 9/1721 121/18639 0.0743801652892562 0.80556182500084 0.796774000263125 0.926920601486261 GO:0015108 chloride transmembrane transporter activity 9/1721 121/18639 0.0743801652892562 0.80556182500084 0.796774000263125 0.926920601486261 GO:0051539 4 iron, 4 sulfur cluster binding 3/1721 45/18639 0.0666666666666667 0.722022080185938 0.798060443080291 0.926920601486261 GO:0004527 exonuclease activity 6/1721 84/18639 0.0714285714285714 0.773595085913505 0.799269289675894 0.926920601486261 GO:0070888 E-box binding 4/1721 59/18639 0.0677966101694915 0.734259742561971 0.806356738830803 0.926920601486261 GO:0004549 tRNA-specific ribonuclease activity 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0008429 phosphatidylethanolamine binding 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0008484 sulfuric ester hydrolase activity 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0008569 minus-end-directed microtubule motor activity 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0009881 photoreceptor activity 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0030169 low-density lipoprotein particle binding 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0032183 SUMO binding 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0032977 membrane insertase activity 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:1901567 fatty acid derivative binding 1/1721 17/18639 0.0588235294117647 0.637078306046416 0.807501896429504 0.926920601486261 GO:0120015 sterol transfer activity 2/1721 32/18639 0.0625 0.676895700174317 0.808574066700124 0.926920601486261 GO:0160041 neuropeptide activity 2/1721 32/18639 0.0625 0.676895700174317 0.808574066700124 0.926920601486261 GO:0099106 ion channel regulator activity 12/1721 160/18639 0.075 0.812274840209181 0.813686342723104 0.931901151005517 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 21/1721 268/18639 0.0783582089552239 0.848645355442428 0.815318267714398 0.932890082003091 GO:0016758 hexosyltransferase activity 15/1721 197/18639 0.0761421319796954 0.824644507826579 0.818132693938169 0.93522889872028 GO:0061733 protein-lysine-acetyltransferase activity 3/1721 47/18639 0.0638297872340425 0.691297736348239 0.821638236236179 0.935485166816627 GO:0019239 deaminase activity 2/1721 33/18639 0.0606060606060606 0.656383709259944 0.822116558824457 0.935485166816627 GO:0140416 transcription regulator inhibitor activity 2/1721 33/18639 0.0606060606060606 0.656383709259944 0.822116558824457 0.935485166816627 GO:0004706 JUN kinase kinase kinase activity 1/1721 18/18639 0.0555555555555556 0.601685066821615 0.825292103509561 0.935485166816627 GO:0016854 racemase and epimerase activity 1/1721 18/18639 0.0555555555555556 0.601685066821615 0.825292103509561 0.935485166816627 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1721 18/18639 0.0555555555555556 0.601685066821615 0.825292103509561 0.935485166816627 GO:0050811 GABA receptor binding 1/1721 18/18639 0.0555555555555556 0.601685066821615 0.825292103509561 0.935485166816627 GO:0070628 proteasome binding 1/1721 18/18639 0.0555555555555556 0.601685066821615 0.825292103509561 0.935485166816627 GO:1990381 ubiquitin-specific protease binding 1/1721 18/18639 0.0555555555555556 0.601685066821615 0.825292103509561 0.935485166816627 GO:0005096 GTPase activator activity 21/1721 271/18639 0.0774907749077491 0.8392507574117 0.830053352218502 0.939748856165464 GO:0032266 phosphatidylinositol-3-phosphate binding 3/1721 48/18639 0.0625 0.676895700174317 0.832520031682116 0.939748856165464 GO:0005525 GTP binding 30/1721 378/18639 0.0793650793650794 0.85955009545945 0.833709455314791 0.939748856165464 GO:0019003 GDP binding 5/1721 75/18639 0.0666666666666667 0.722022080185938 0.833770062489623 0.939748856165464 GO:0008175 tRNA methyltransferase activity 2/1721 34/18639 0.0588235294117647 0.637078306046416 0.834791969526346 0.939748856165464 GO:0030332 cyclin binding 2/1721 34/18639 0.0588235294117647 0.637078306046416 0.834791969526346 0.939748856165464 GO:0035091 phosphatidylinositol binding 22/1721 284/18639 0.0774647887323944 0.838969318525914 0.835247169936453 0.939748856165464 GO:0070851 growth factor receptor binding 10/1721 139/18639 0.0719424460431655 0.779160518186264 0.836719035776201 0.939748856165464 GO:0015081 sodium ion transmembrane transporter activity 12/1721 164/18639 0.0731707317073171 0.792463258740664 0.838356633494286 0.939748856165464 GO:0042277 peptide binding 19/1721 249/18639 0.0763052208835341 0.826410814670652 0.838992376038768 0.939748856165464 GO:0019783 ubiquitin-like protein peptidase activity 9/1721 127/18639 0.0708661417322835 0.767503786024423 0.839895903202981 0.939748856165464 GO:0042800 histone H3K4 methyltransferase activity 1/1721 19/18639 0.0526315789473684 0.570017431725741 0.841439049960345 0.939748856165464 GO:0042834 peptidoglycan binding 1/1721 19/18639 0.0526315789473684 0.570017431725741 0.841439049960345 0.939748856165464 GO:0046527 glucosyltransferase activity 1/1721 19/18639 0.0526315789473684 0.570017431725741 0.841439049960345 0.939748856165464 GO:0120227 acyl-CoA binding 1/1721 19/18639 0.0526315789473684 0.570017431725741 0.841439049960345 0.939748856165464 GO:0140036 ubiquitin-modified protein reader activity 1/1721 19/18639 0.0526315789473684 0.570017431725741 0.841439049960345 0.939748856165464 GO:0008238 exopeptidase activity 7/1721 102/18639 0.0686274509803922 0.743258023720819 0.842286308207798 0.939830494636274 GO:0101005 deubiquitinase activity 8/1721 115/18639 0.0695652173913043 0.753414344541849 0.844008732738677 0.940887604724292 GO:0000175 3'-5'-RNA exonuclease activity 2/1721 35/18639 0.0571428571428571 0.618876068730804 0.846644856081461 0.942096109333542 GO:0034061 DNA polymerase activity 2/1721 35/18639 0.0571428571428571 0.618876068730804 0.846644856081461 0.942096109333542 GO:0003724 RNA helicase activity 5/1721 77/18639 0.0649350649350649 0.703268259921368 0.850221406014714 0.945209511814893 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 12/1721 167/18639 0.0718562874251497 0.778227391817179 0.85515944094637 0.946609816999792 GO:0001614 purinergic nucleotide receptor activity 1/1721 20/18639 0.05 0.541516560139454 0.856094441744354 0.946609816999792 GO:0016004 phospholipase activator activity 1/1721 20/18639 0.05 0.541516560139454 0.856094441744354 0.946609816999792 GO:0016502 nucleotide receptor activity 1/1721 20/18639 0.05 0.541516560139454 0.856094441744354 0.946609816999792 GO:0016505 peptidase activator activity involved in apoptotic process 1/1721 20/18639 0.05 0.541516560139454 0.856094441744354 0.946609816999792 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/1721 91/18639 0.0659340659340659 0.714087771612467 0.856238012106695 0.946609816999792 GO:0004190 aspartic-type endopeptidase activity 2/1721 36/18639 0.0555555555555556 0.601685066821615 0.857718944563238 0.946609816999792 GO:0005484 SNAP receptor activity 2/1721 36/18639 0.0555555555555556 0.601685066821615 0.857718944563238 0.946609816999792 GO:0001217 DNA-binding transcription repressor activity 21/1721 278/18639 0.0755395683453237 0.818118544095578 0.86105646895161 0.948866937209074 GO:0030544 Hsp70 protein binding 3/1721 51/18639 0.0588235294117647 0.637078306046416 0.86179561595241 0.948866937209074 GO:0120013 lipid transfer activity 4/1721 65/18639 0.0615384615384615 0.666481920171635 0.862108922357174 0.948866937209074 GO:0046332 SMAD binding 5/1721 79/18639 0.0632911392405063 0.685464000176524 0.865297612545799 0.951513860172644 GO:0022829 wide pore channel activity 2/1721 37/18639 0.0540540540540541 0.585423308258869 0.868056903505878 0.952291081774548 GO:0070001 aspartic-type peptidase activity 2/1721 37/18639 0.0540540540540541 0.585423308258869 0.868056903505878 0.952291081774548 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1721 21/18639 0.0476190476190476 0.51573005727567 0.869395986712288 0.952291081774548 GO:0051213 dioxygenase activity 6/1721 93/18639 0.0645161290322581 0.698731045341231 0.869834423057334 0.952291081774548 GO:0008235 metalloexopeptidase activity 4/1721 66/18639 0.0606060606060606 0.656383709259944 0.869926531868183 0.952291081774548 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1721 67/18639 0.0597014925373134 0.646586937479945 0.877359286968871 0.953745975268874 GO:0000146 microfilament motor activity 2/1721 38/18639 0.0526315789473684 0.570017431725741 0.877700166402726 0.953745975268874 GO:0005501 retinoid binding 2/1721 38/18639 0.0526315789473684 0.570017431725741 0.877700166402726 0.953745975268874 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/1721 38/18639 0.0526315789473684 0.570017431725741 0.877700166402726 0.953745975268874 GO:0019840 isoprenoid binding 2/1721 38/18639 0.0526315789473684 0.570017431725741 0.877700166402726 0.953745975268874 GO:0004518 nuclease activity 15/1721 209/18639 0.0717703349282297 0.777296497807828 0.878283895535982 0.953745975268874 GO:0005543 phospholipid binding 39/1721 497/18639 0.0784708249496982 0.849865023961316 0.878766755213195 0.953745975268874 GO:0005243 gap junction channel activity 1/1721 22/18639 0.0454545454545455 0.492287781944958 0.881468685545039 0.953745975268874 GO:0008649 rRNA methyltransferase activity 1/1721 22/18639 0.0454545454545455 0.492287781944958 0.881468685545039 0.953745975268874 GO:0008970 phospholipase A1 activity 1/1721 22/18639 0.0454545454545455 0.492287781944958 0.881468685545039 0.953745975268874 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1721 22/18639 0.0454545454545455 0.492287781944958 0.881468685545039 0.953745975268874 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1721 22/18639 0.0454545454545455 0.492287781944958 0.881468685545039 0.953745975268874 GO:0140035 ubiquitin-like protein reader activity 1/1721 22/18639 0.0454545454545455 0.492287781944958 0.881468685545039 0.953745975268874 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 8/1721 122/18639 0.0655737704918033 0.710185652641907 0.885720773956329 0.957071703619623 GO:0008234 cysteine-type peptidase activity 13/1721 187/18639 0.0695187165775401 0.752910725327583 0.890681142188897 0.957071703619623 GO:0008083 growth factor activity 11/1721 162/18639 0.0679012345679012 0.735392859448641 0.892094005049477 0.957071703619623 GO:0003887 DNA-directed DNA polymerase activity 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:0005212 structural constituent of eye lens 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:0071617 lysophospholipid acyltransferase activity 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:0140102 catalytic activity, acting on a rRNA 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1721 23/18639 0.0434782608695652 0.470883965338655 0.892426003704623 0.957071703619623 GO:0008374 O-acyltransferase activity 3/1721 55/18639 0.0545454545454545 0.59074533833395 0.893781682211996 0.957360810636767 GO:0004532 RNA exonuclease activity 2/1721 40/18639 0.05 0.541516560139454 0.895061383914935 0.957360810636767 GO:0015144 carbohydrate transmembrane transporter activity 2/1721 40/18639 0.05 0.541516560139454 0.895061383914935 0.957360810636767 GO:0008170 N-methyltransferase activity 6/1721 98/18639 0.0612244897959184 0.663081502211576 0.899189776714895 0.960929919834403 GO:0005315 phosphate transmembrane transporter activity 1/1721 24/18639 0.0416666666666667 0.451263800116211 0.902370935356124 0.961789565866844 GO:0030552 cAMP binding 1/1721 24/18639 0.0416666666666667 0.451263800116211 0.902370935356124 0.961789565866844 GO:0060229 lipase activator activity 1/1721 24/18639 0.0416666666666667 0.451263800116211 0.902370935356124 0.961789565866844 GO:0140767 enzyme-substrate adaptor activity 9/1721 139/18639 0.0647482014388489 0.701244466367638 0.904376239083033 0.963081363374388 GO:0008168 methyltransferase activity 14/1721 204/18639 0.0686274509803922 0.743258023720819 0.907435729991854 0.965492529544357 GO:0004402 histone acetyltransferase activity 2/1721 42/18639 0.0476190476190476 0.51573005727567 0.910105052455208 0.967164266280592 GO:0017056 structural constituent of nuclear pore 1/1721 25/18639 0.04 0.433213248111563 0.911396969213342 0.967164266280592 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1721 25/18639 0.04 0.433213248111563 0.911396969213342 0.967164266280592 GO:0004197 cysteine-type endopeptidase activity 5/1721 88/18639 0.0568181818181818 0.615359727431197 0.918205076349523 0.970766090372281 GO:0015459 potassium channel regulator activity 3/1721 59/18639 0.0508474576271186 0.550694806921478 0.918955267190857 0.970766090372281 GO:0031593 polyubiquitin modification-dependent protein binding 3/1721 59/18639 0.0508474576271186 0.550694806921478 0.918955267190857 0.970766090372281 GO:0019865 immunoglobulin binding 1/1721 26/18639 0.0384615384615385 0.416551200107272 0.919588965344418 0.970766090372281 GO:0030247 polysaccharide binding 1/1721 26/18639 0.0384615384615385 0.416551200107272 0.919588965344418 0.970766090372281 GO:0051139 metal cation:proton antiporter activity 1/1721 26/18639 0.0384615384615385 0.416551200107272 0.919588965344418 0.970766090372281 GO:0043014 alpha-tubulin binding 2/1721 44/18639 0.0454545454545455 0.492287781944958 0.923108429804619 0.973634781740058 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 3/1721 60/18639 0.05 0.541516560139454 0.924333535802288 0.974080653180536 GO:0005044 scavenger receptor activity 1/1721 27/18639 0.037037037037037 0.401123377881077 0.927023951141563 0.976068583422252 GO:0003730 mRNA 3'-UTR binding 18/1721 262/18639 0.0687022900763359 0.744068555916807 0.929846106241284 0.978191657692304 GO:0005242 inward rectifier potassium channel activity 1/1721 28/18639 0.0357142857142857 0.386797542956753 0.93377184390351 0.979774432583286 GO:0046966 nuclear thyroid hormone receptor binding 1/1721 28/18639 0.0357142857142857 0.386797542956753 0.93377184390351 0.979774432583286 GO:0141052 histone H3 demethylase activity 1/1721 28/18639 0.0357142857142857 0.386797542956753 0.93377184390351 0.979774432583286 GO:0010484 histone H3 acetyltransferase activity 1/1721 29/18639 0.0344827586206897 0.373459696647899 0.93989610679331 0.985033541614706 GO:0008528 G protein-coupled peptide receptor activity 7/1721 122/18639 0.0573770491803279 0.621412446061668 0.941108181372391 0.985033541614706 GO:0004843 cysteine-type deubiquitinase activity 6/1721 108/18639 0.0555555555555556 0.601685066821615 0.941218211098072 0.985033541614706 GO:0008188 neuropeptide receptor activity 2/1721 48/18639 0.0416666666666667 0.451263800116211 0.943975246529548 0.986066644324611 GO:0032452 histone demethylase activity 1/1721 30/18639 0.0333333333333333 0.361011040092969 0.945454344311242 0.986066644324611 GO:0048019 receptor antagonist activity 1/1721 30/18639 0.0333333333333333 0.361011040092969 0.945454344311242 0.986066644324611 GO:0070566 adenylyltransferase activity 1/1721 30/18639 0.0333333333333333 0.361011040092969 0.945454344311242 0.986066644324611 GO:0016411 acylglycerol O-acyltransferase activity 1/1721 31/18639 0.032258064516129 0.349365522670615 0.950498842857126 0.988779430358655 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1721 31/18639 0.032258064516129 0.349365522670615 0.950498842857126 0.988779430358655 GO:0140457 protein demethylase activity 1/1721 31/18639 0.032258064516129 0.349365522670615 0.950498842857126 0.988779430358655 GO:0008173 RNA methyltransferase activity 3/1721 67/18639 0.0447761194029851 0.484940203109959 0.953698951948867 0.991259013412606 GO:0001653 peptide receptor activity 7/1721 128/18639 0.0546875 0.592283737652528 0.957315332354032 0.994166649681604 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1721 69/18639 0.0434782608695652 0.470883965338655 0.959885966810914 0.995984242485854 GO:0008146 sulfotransferase activity 2/1721 53/18639 0.0377358490566038 0.408691743501475 0.962540979788407 0.997178715649895 GO:0016782 transferase activity, transferring sulphur-containing groups 3/1721 70/18639 0.0428571428571429 0.464157051548103 0.962679946245204 0.997178715649895 GO:0010485 histone H4 acetyltransferase activity 1/1721 35/18639 0.0285714285714286 0.309438034365402 0.966425287543658 0.999352895296424 GO:0140566 histone reader activity 1/1721 35/18639 0.0285714285714286 0.309438034365402 0.966425287543658 0.999352895296424 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1721 36/18639 0.0277777777777778 0.300842533410808 0.969531183057385 0.99999986751286 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1721 56/18639 0.0357142857142857 0.386797542956753 0.97067199906566 0.99999986751286 GO:0035064 methylated histone binding 3/1721 74/18639 0.0405405405405405 0.439067481194152 0.972124638581598 0.99999986751286 GO:0140034 methylation-dependent protein binding 3/1721 76/18639 0.0394736842105263 0.427513073794306 0.97594989133888 0.99999986751286 GO:0032451 demethylase activity 1/1721 40/18639 0.025 0.270758280069727 0.979336449318123 0.99999986751286 GO:0016755 aminoacyltransferase activity 33/1721 496/18639 0.0665322580645161 0.720566390508144 0.985011304806112 0.99999986751286 GO:0160215 deacylase activity 2/1721 65/18639 0.0307692307692308 0.333240960085818 0.98609361116921 0.99999986751286 GO:0004180 carboxypeptidase activity 1/1721 46/18639 0.0217391304347826 0.235441982669328 0.988461282081324 0.99999986751286 GO:0140098 catalytic activity, acting on RNA 24/1721 387/18639 0.062015503875969 0.671648446684594 0.988528463836711 0.99999986751286 GO:0140101 catalytic activity, acting on a tRNA 6/1721 139/18639 0.0431654676258993 0.467496310911759 0.990899653205485 0.99999986751286 GO:0019787 ubiquitin-like protein transferase activity 30/1721 479/18639 0.0626304801670146 0.678308843598481 0.993190643833931 0.99999986751286 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/1721 53/18639 0.0188679245283019 0.204345871750737 0.994154425606374 0.99999986751286 GO:0015085 calcium ion transmembrane transporter activity 6/1721 147/18639 0.0408163265306122 0.442054334807717 0.99458726465785 0.99999986751286 GO:0140463 chromatin-protein adaptor activity 1/1721 54/18639 0.0185185185185185 0.200561688940538 0.994695705792074 0.99999986751286 GO:0030594 neurotransmitter receptor activity 3/1721 97/18639 0.0309278350515464 0.334958696993477 0.995178134547844 0.99999986751286 GO:0004842 ubiquitin-protein transferase activity 27/1721 449/18639 0.0601336302895323 0.651267132461704 0.995345802586341 0.99999986751286 GO:0046873 metal ion transmembrane transporter activity 27/1721 450/18639 0.06 0.649819872167344 0.995533472903651 0.99999986751286 GO:0005249 voltage-gated potassium channel activity 3/1721 98/18639 0.0306122448979592 0.331540751105788 0.995543263647633 0.99999986751286 GO:0099094 ligand-gated monoatomic cation channel activity 5/1721 136/18639 0.0367647058823529 0.39817394127901 0.996294772666983 0.99999986751286 GO:0140030 modification-dependent protein binding 7/1721 173/18639 0.0404624277456647 0.438221493754471 0.997148946185599 0.99999986751286 GO:0061630 ubiquitin protein ligase activity 19/1721 353/18639 0.0538243626062323 0.582935673804511 0.99741602447524 0.99999986751286 GO:0005267 potassium channel activity 4/1721 124/18639 0.032258064516129 0.349365522670615 0.997517354577363 0.99999986751286 GO:0022824 transmitter-gated monoatomic ion channel activity 1/1721 63/18639 0.0158730158730159 0.17191001909189 0.997788311401103 0.99999986751286 GO:0022835 transmitter-gated channel activity 1/1721 63/18639 0.0158730158730159 0.17191001909189 0.997788311401103 0.99999986751286 GO:0061659 ubiquitin-like protein ligase activity 20/1721 372/18639 0.0537634408602151 0.582275871117692 0.997963819771782 0.99999986751286 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1721 73/18639 0.0136986301369863 0.14836070140807 0.999163661552222 0.99999986751286 GO:0030527 structural constituent of chromatin 2/1721 98/18639 0.0204081632653061 0.221027167403859 0.99919104549078 0.99999986751286 GO:0015079 potassium ion transmembrane transporter activity 5/1721 160/18639 0.03125 0.338447850087159 0.999344827767099 0.99999986751286 GO:0005262 calcium channel activity 3/1721 131/18639 0.0229007633587786 0.248022851972269 0.999694851004869 0.99999986751286 GO:0005244 voltage-gated monoatomic ion channel activity 5/1721 173/18639 0.0289017341040462 0.313015352681765 0.999752646349932 0.99999986751286 GO:0003823 antigen binding 5/1721 174/18639 0.028735632183908 0.311216413873249 0.99977070930016 0.99999986751286 GO:0022832 voltage-gated channel activity 5/1721 175/18639 0.0285714285714286 0.309438034365402 0.999787479127174 0.99999986751286 GO:0022843 voltage-gated monoatomic cation channel activity 3/1721 143/18639 0.020979020979021 0.227209745513058 0.99988850627906 0.99999986751286 GO:0015276 ligand-gated monoatomic ion channel activity 5/1721 186/18639 0.0268817204301075 0.291137935558846 0.99990854264309 0.99999986751286 GO:0045182 translation regulator activity 15/1721 356/18639 0.0421348314606742 0.456334179892798 0.99991044731901 0.99999986751286 GO:0022834 ligand-gated channel activity 5/1721 188/18639 0.0265957446808511 0.288040723478433 0.999921655333664 0.99999986751286 GO:0022836 gated channel activity 11/1721 318/18639 0.0345911949685535 0.374634098209685 0.999984098649767 0.99999986751286 GO:0005216 monoatomic ion channel activity 19/1721 448/18639 0.0424107142857143 0.459322082261144 0.999984479225105 0.99999986751286 GO:0005261 monoatomic cation channel activity 10/1721 341/18639 0.0293255131964809 0.31760502060965 0.999999077739799 0.99999986751286 GO:0030371 translation repressor activity 8/1721 329/18639 0.0243161094224924 0.263351518608853 0.99999986751286 0.99999986751286