category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	107/1585	222/9376	2.85114388836786	RPL4/RPLP0/RPL3/RPSA/RPL10A/RPL5/RPL31/RPL35/RPL29/RPL6/RPL36/RPS7/RPL7A/RPL14/RPS3/RPS5/RPL23A/RPL35A/RPS3A/RPL18/RPS4X/RPL7/RPS6/RPL18A/RPS27/RPL37A/RPS18/RPL8/RPL22/RPL11/RPL24/RPL37/RPS23/RPL27A/RPS25/RPL19/RPS15/RPS19/RPL15/RPL12/RPS13/RPS2/RPS27A/RPL32/RPS12/RPL13/RPL26/RPS16/RPS8/RPL9/RPL34/RPS14/RPL39/RPL10/RPS24/RPS15A/RPL13A/RPS20/RPL30/RPLP2/RPL21/RPLP1/RPL38/RPS11/RPS9/RPS28/RPL41/RPS29/RPL23/RPL28/RPL27/RPS26/UBA52/RPS10/RPS21/MRPL51/RPL36A/FAU/RPS4Y1/MRPS15/RPL17/MRPL14/MRPL11/MRPS26/MRPL20/MRPL27/MRPL44/MRPL33/MRPL43/RPL36AL/MRPS6/DAP3/MRPS30/MRPL54/MRPL23/MRPL17/MRPS33/MRPS10/MRPS23/MRPS18B/MRPL42/MRPL35/MRPL24/MRPL21/MRPS34/MRPS5/MRPS22	12.5896854645565
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	83/1585	158/9376	3.1074871221499	CCNE1/CCNB1/CDKN1C/CDK1/PTTG1/CDC20/CCNB2/MAD2L1/SKP2/WEE1/CCNA2/AURKB/CDT1/CDC6/SFN/MCM7/CDCA5/NDC80/ORC6/MCM4/PLK1/PCNA/TTK/YWHAE/CDK2/CDC45/CDK7/FBXO5/CHEK1/ANAPC11/CDC25A/PKMYT1/CDC25C/BUB1B/MCM3/SKP1/TICRR/MCM2/BUB1/E2F5/CCNE2/TRIP13/TFDP2/ESCO2/RBX1/MCM6/TFDP1/CDC14B/MCM5/YWHAQ/ORC1/CDC7/CCND3/PPP2CB/BUB3/E2F1/DBF4/MAD2L1BP/ANAPC10/MAD2L2/PDS5A/E2F2/ESPL1/GADD45A/STAG2/ANAPC13/RAD21/CDC16/DDX11/CCND2/CDC27/PPP2CA/CDKN1B/FZR1/MTBP/ANAPC4/TP53/HDAC1/ABL1/ORC2/MYC/PPP2R5D/SMC3	12.0497709164339
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	92/1585	238/9376	2.28664740344087	RPL4/RPLP0/RPL3/RPSA/RPL10A/RPL5/RPL31/RPL35/RPL29/RPL6/RPL36/RPS7/RPL7A/RPL14/RPS3/RPS5/RPL23A/RPL35A/RPS3A/RPL18/RPS4X/RPL7/RPS6/RPL18A/RPS27/RPL37A/RPS18/RPL8/RPL22/RPL11/RPL24/RPL37/RPS23/RPL27A/RPS25/RPL19/RPS15/RPS19/RPL15/RPL12/RPS13/RPS2/RPS27A/RPL32/RPS12/RPL13/RPL26/RPS16/RPS8/RPL9/RPL34/RPS14/RPL39/RPL10/RPS24/RPS15A/RPL13A/RPS20/RPL30/RPLP2/RPL21/RPLP1/RPL38/RPS11/RPS9/RPS28/RPL41/RPS29/RPL23/RPL28/RPL27/RPS26/UBA52/RPS10/RPS21/F13A1/C1R/RPL36A/FAU/RPS4Y1/RPL17/EGFR/NRP1/C1S/PRKCA/MAPK13/MAPK12/C9/RPL36AL/CCL2/IL6ST/TLR3	9.06830500564049
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	26/1585	36/9376	4.27227479845776	MCM7/MCM4/PCNA/FEN1/RPA3/RFC3/RNASEH2A/SSBP1/RFC4/MCM3/MCM2/RFC2/POLE2/LIG1/DNA2/PRIM1/POLD2/MCM6/RFC5/MCM5/POLE/RPA2/POLA2/POLA1/POLD3/POLE4	8.87219848705507
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	83/1585	268/9376	1.8320259899242	GNAI1/TUBA1B/RPS27A/CALM1/TUBB/UQCRH/COX8C/UBA52/TUBA1C/SLC25A4/TUBB4B/NDUFA4/PARK7/COX6C/SOD1/NDUFS5/PSMA7/PSMB1/UBB/ADCY5/UQCR10/NDUFA6/PSMB5/NDUFA11/GNAS/SLC25A6/COX5A/NDUFV2/PSMB6/SLC18A2/NDUFB10/PSMC3/GPR37/NDUFB11/PSMB7/PSMB2/COX5B/VDAC1/NDUFAB1/PSMA4/UBE2L3/SDHA/SLC39A7/COX7C/UBA1/TXN2/NDUFA9/NDUFA12/NDUFS2/TXN/COX4I1/DAXX/NDUFS6/SDHC/NDUFA8/NDUFC1/UQCRC1/NDUFB4/UBE2G1/PSMD3/NDUFS3/SLC39A1/COX7A2L/PSMC5/PSMB4/PSMD4/PSMA3/CASP3/UBE2J2/PSMC4/MFN1/APAF1/HTRA2/TP53/NDUFC2/PSMA1/HSPA5/SLC39A10/CAMK2G/NDUFA13/SLC39A4/PSMC6/VDAC2	6.23299025463299
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	28/1585	63/9376	2.62909218366632	PCNA/CDK7/RPA3/RFC3/RFC4/POLR2H/RFC2/POLR2L/POLE2/LIG1/RBX1/POLD2/RFC5/POLR2F/POLE/POLR2I/XPA/RPA2/CUL4A/ERCC3/CETN2/RAD23A/DDB1/POLD3/GTF2H3/ERCC2/RAD23B/POLE4	5.85160230760979
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	15/1585	23/9376	3.85790700864079	PCNA/RPA3/RFC3/SSBP1/RFC4/EXO1/RFC2/MSH2/LIG1/POLD2/RFC5/MSH6/RPA2/MSH3/POLD3	6.18928118604675
Genetic Information Processing	Transcription	hsa03040	Spliceosome	68/1585	243/9376	1.65535433786398	SNRPD2/HNRNPA1/SNRPD1/HNRNPA3/SNRPG/SNRPB/SRSF3/SNRPF/LSM7/HNRNPC/SNRPE/LSM3/RBM8A/LSM4/SNRPD3/U2AF1/HNRNPM/SRSF2/SNRPA1/HNRNPK/SRSF7/SRSF9/ALYREF/LSM2/MAGOHB/PPIL1/LSM5/RBMX2/FUS/PRPF6/CRNKL1/ISY1/SNRPC/CTNNBL1/CCDC12/SF1/MAGOH/SART1/NCBP2/ACIN1/SNRPA/PRPF8/PLRG1/RBMX/HNRNPA1L2/CDC5L/SMNDC1/SNW1/SNRNP27/RBM22/GPKOW/DHX16/THOC6/WBP11/TXNL4A/SRSF5/XAB2/SNRNP200/PPIE/DHX38/BUD13/DDX42/SNRNP70/THOC7/THOC3/THOC5/PRPF19/PPIH	4.66848809538598
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	20/1585	44/9376	2.68884427874964	HMGB1/PCNA/FEN1/RFC3/UNG/RFC4/PARP1/RFC2/POLE2/LIG1/POLD2/RFC5/POLE/NEIL3/APTX/XRCC1/LIG3/NTHL1/POLD3/POLE4	5.06444955237295
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	19/1585	41/9376	2.74130953296915	RAD51/XRCC2/RPA3/SSBP1/RAD54L/BLM/POLD2/RAD51C/BRCA1/EME1/BRIP1/RAD54B/RPA2/MUS81/XRCC3/BABAM1/POLD3/TOP3A/RAD51B	5.03981290358511
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1585	75/9376	2.12956466876972	CCNE1/CCNB1/PERP/RRM2/CDK1/CCNB2/SFN/GTSE1/SIVA1/CDK2/CHEK1/IGF1/IGFBP3/CCNE2/PPP1R13L/CCND3/EI24/PTEN/GADD45A/MDM4/RCHY1/CCND2/SESN1/CASP3/APAF1/TP53/CCNG1	4.42976389003857
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	79/1585	308/9376	1.5172764144373	TUBA1B/TUBB/UQCRH/COX8C/GPX8/TUBA1C/SLC25A4/GPX3/TUBB4B/NDUFA4/COX6C/SOD1/NDUFS5/PSMA7/PSMB1/POLR2H/POLR2L/UQCR10/NDUFA6/PSMB5/NDUFA11/CLTA/SLC25A6/COX5A/DNALI1/NDUFV2/PSMB6/NDUFB10/PSMC3/NDUFB11/PSMB7/TFAM/PSMB2/COX5B/VDAC1/POLR2F/NDUFAB1/PSMA4/SDHA/AP2A2/COX7C/POLR2I/NDUFA9/NDUFA12/NDUFS2/DCTN6/CLTC/COX4I1/WIPI1/NDUFS6/CLTB/SDHC/NDUFA8/NDUFC1/UQCRC1/NDUFB4/PSMD3/NDUFS3/COX7A2L/PSMC5/PSMB4/PSMD4/PSMA3/CASP3/AP2A1/PSMC4/APAF1/RCOR1/TP53/HDAC1/NDUFC2/PSMA1/TGM2/NDUFA13/PSMC6/AP2M1/VDAC2/TAF4B/PLCB3	4.16337901373513
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	91/1585	368/9376	1.4627897407763	TUBA1B/HNRNPA1/TUBB/UQCRH/COX8C/GPX8/TUBA1C/HNRNPA3/HNRNPA2B1/SRSF3/GPX3/TUBB4B/NDUFA4/COX6C/SOD1/NDUFS5/PSMA7/PSMB1/UQCR10/NDUFA6/PSMB5/NDUFA11/COX5A/DNALI1/NDUFV2/NOS2/PSMB6/SRSF7/ALYREF/NDUFB10/PSMC3/NDUFB11/PSMB7/NUP37/ANXA7/PSMB2/COX5B/VDAC1/NDUFAB1/PSMA4/SDHA/MAPK13/MAPK12/COX7C/CHMP2B/ACTG1/FUS/CCS/NDUFA9/NDUFA12/NDUFS2/DCTN6/COX4I1/OPTN/WIPI1/DAXX/ATXN2/NDUFS6/SDHC/NDUFA8/NDUFC1/HNRNPA1L2/PFN2/NUP93/NUP155/UQCRC1/NDUFB4/TPR/PSMD3/BAD/NUP98/NDUFS3/COX7A2L/PSMC5/PSMB4/NRG1/PSMD4/PSMA3/CASP3/PSMC4/NUP188/APAF1/TP53/NDUFC2/PSMA1/HSPA5/NXT1/NDUFA13/PSMC6/MAP2K6/GRIN2D	4.08504751845789
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	48/1585	170/9376	1.67024679903507	CLDN4/JAM3/CLDN6/CLDN10/TUBA1B/CLDN7/TUBA1C/PARD3/MYH10/PCNA/CLDN3/CTTN/EPB41L4B/PRKCZ/MPDZ/EZR/MARVELD2/PARD6B/ERBB2/ARPC1A/CLDN19/DLG3/AMOTL2/TJP1/MAGI1/MYL12B/CD1C/CRB3/AMOT/TJP3/NEDD4/AMOTL1/CGNL1/MYL9/PPP2CB/MARVELD3/ACTG1/MYH9/ARPC5L/OCLN/HSPA4/PPP2CA/ACTR3B/SYMPK/RAB8B/PPP2R2A/DLG1/TJAP1	3.9776575752093
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	65/1585	250/9376	1.5380189274448	HLA-G/CAV1/PARD3/PRKCZ/FOLR1/CAV2/PARD6B/LDLR/EPN3/ARPC1A/EPN2/CLTA/RAB11A/ASAP3/AGAP1/ZFYVE9/FGFR3/NEDD4/RAB11FIP4/BIN1/EGFR/FOLR2/RAB11FIP5/EPN1/CHMP1A/AP2A2/CHMP4C/ARF5/CHMP2B/SNX3/RAB11B/VPS26A/VTA1/DNM2/RAB4A/VPS37A/CLTC/CHMP6/TSG101/RAB35/STAMBP/ARPC5L/VPS4A/SNX12/IL2RB/SNX4/CLTB/MVB12A/SH3GL1/SNF8/GBF1/EPS15/HRAS/ARFGAP2/PSD4/DAB2/ACAP3/ARFGAP1/ACTR3B/AP2A1/EHD3/WASL/IL2RA/AP2M1/SNX6	3.88893778858603
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	44/1585	154/9376	1.69013068949977	PSAT1/ALAS2/AK5/DHFR/UGP2/QPRT/AK1/SHMT1/GGH/NME1/MTHFD1L/AK3/UROD/MOCS2/GMPPA/DLD/CTPS1/UROS/GSS/UMPS/VKORC1L1/PANK3/COASY/COQ6/MTHFD2L/HMBS/LIPT2/FECH/MOCS1/PANK1/LIAS/AK2/ALAD/MPI/COQ7/PMM2/PMM1/COQ5/NFS1/PHOSPHO2/COQ3/GGCX/COQ4/NADK2	3.89477892473735
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	30/1585	93/9376	1.90821206879007	CCNE1/CKS1B/SKP2/LAMA4/TRAF4/COL4A2/COL4A1/LAMB1/CDK2/PTK2/CKS2/LAMA5/CCNE2/NOS2/LAMC1/LAMA1/PTEN/E2F1/LAMC2/AKT2/FHIT/E2F2/LAMA2/GADD45A/CDKN1B/CASP3/APAF1/TP53/MYC/LAMB2	3.96997925232821
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	20/1585	54/9376	2.19091015305526	UBE2T/RAD51/FANCI/RPA3/FANCE/RMI2/BLM/FANCD2/RAD51C/FANCB/BRCA1/EME1/BRIP1/REV1/WDR48/USP1/RPA2/FANCG/MUS81/TOP3A	3.95844848791078
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	69/1585	275/9376	1.4842420418698	CAV1/TUBA1B/TUBB/UQCRH/COX8C/TUBA1C/SLC25A4/TUBB4B/NDUFA4/CAV2/COX6C/SOD1/NDUFS5/PSMA7/PSMB1/UQCR10/NDUFA6/PSMB5/NDUFA11/SLC25A6/COX5A/NDUFV2/PSMB6/LAMC1/NDUFB10/PSMC3/NDUFB11/PSMB7/PSMB2/COX5B/VDAC1/NDUFAB1/PSMA4/SDHA/MAPK13/MAPK12/COX7C/C9/NDUFA9/NDUFA12/NDUFS2/COX4I1/CSNK2A2/NDUFS6/SDHC/ATF2/NDUFA8/NDUFC1/UQCRC1/NDUFB4/PSMD3/CSNK2A1/BAD/NDUFS3/COX7A2L/PSMC5/PSMB4/PSMD4/PSMA3/CASP3/PSMC4/APAF1/NDUFC2/PSMA1/HSPA5/NDUFA13/PSMC6/VDAC2/GRIN2D	3.67610536927684
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	33/1585	108/9376	1.80750087627059	RAN/EEF1A1/RBM8A/KPNA2/SAP18/ALYREF/CSE1L/MAGOHB/NUP37/RANBP17/SUMO2/MAGOH/NMD3/NCBP2/ACIN1/IPO7/UPF3A/NUP93/NUP155/TPR/NUP98/SNUPN/PHAX/UPF3B/THOC6/NUP188/UPF2/NXT1/THOC7/THOC3/XPO1/THOC5/IPO5	3.8068480012275
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	39/1585	138/9376	1.67175970374434	CCNE1/CCNB1/CDK1/PTTG1/CDC20/CCNB2/MAD2L1/CALM1/AURKA/PLK1/YWHAE/CDK2/FBXO5/ANAPC11/PKMYT1/CDC25C/SKP1/ADCY5/IGF1/BUB1/CCNE2/ADCY6/RBX1/YWHAQ/SLK/MAPK13/MAPK12/PPP2CB/ANAPC10/MAD2L2/ESPL1/ANAPC13/CDC16/CDC27/PPP2CA/ANAPC4/CAMK2G/PPP2R5D/SMC3	3.5856523691723
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	59/1585	233/9376	1.49790552524336	TPM1/DSP/CSRP2/DIAPH3/MYL4/FHL2/PDLIM1/DSG2/SYNE2/PKP2/LMNB1/COL4A2/MYH10/COL4A1/TPM2/NID1/FBLN1/SGCE/ENO1/LMNB2/COL9A3/JUP/COL1A1/SGCB/ANK3/DSC2/COL27A1/DAG1/ITGB4/COL1A2/COL6A3/FLNC/TNNC1/COL3A1/FBLN2/LAMA1/NEBL/ATP1A4/COL6A2/TNNT3/MYL9/COL5A2/DMD/ACTG1/MYH9/LMOD1/COL5A1/TPM4/ITGA1/DCN/EMD/INF2/LAMA2/TMOD3/SDC1/SPTBN1/ITGA9/ITGB8/PDLIM2	3.47123659464948
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	53/1585	205/9376	1.52936216049858	SLC2A1/GAPDH/UQCRH/COX8C/SLC25A4/PRKCZ/MMP2/NDUFA4/COX6C/COL1A1/NDUFS5/PARP1/UQCR10/NDUFA6/NDUFA11/SLC25A6/COX5A/NDUFV2/COL1A2/NDUFB10/NDUFB11/COL3A1/CPT2/COX5B/VDAC1/NDUFAB1/PRKCA/SDHA/MAPK13/MAPK12/PTEN/COX7C/NDUFA9/NDUFA12/NDUFS2/COX4I1/GSR/AKT2/NDUFS6/SDHC/NDUFA8/NDUFC1/UQCRC1/NDUFB4/NDUFS3/COX7A2L/NDUFC2/INSR/CAMK2G/GYS1/NDUFA13/VDAC2/PLCB3	3.45640915867146
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	108/1585	480/9376	1.33097791798107	TUBA1B/RPS27A/CALM1/TUBB/UQCRH/COX8C/UBA52/GPX8/TUBA1C/WNT7A/SLC25A4/AXIN2/GPX3/TUBB4B/NDUFA4/PARK7/COX6C/SOD1/NDUFS5/PSMA7/PSMB1/FZD3/UBB/WNT10B/UQCR10/NDUFA6/PSMB5/NDUFA11/LRP6/SLC25A6/COX5A/DNALI1/NDUFV2/NOS2/PSMB6/DKK1/NDUFB10/PSMC3/GPR37/NDUFB11/PSMB7/PSMB2/COX5B/VDAC1/NDUFAB1/PRKCA/PSMA4/UBE2L3/SDHA/MAPK13/MAPK12/LRP5/COX7C/FZD1/CHMP2B/UBA1/FUS/CCS/NDUFA9/NDUFA12/NDUFS2/DCTN6/COX4I1/OPTN/WIPI1/DAXX/ATXN2/CSNK2A2/NDUFS6/SDHC/CAPN1/NDUFA8/NDUFC1/UQCRC1/NDUFB4/UBE2G1/PSMD3/CSNK2A1/BAD/NDUFS3/HRAS/FRAT2/COX7A2L/PSMC5/PSMB4/PSMD4/FZD6/PSMA3/CASP3/PPID/UBE2J2/PSMC4/MFN1/APAF1/HTRA2/APP/NDUFC2/PSMA1/HSPA5/CAMK2G/NDUFA13/PSMC6/CHRM5/VDAC2/MAP2K6/GRIN2D/CSNK1A1/PLCB3	3.35757653112787
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	90/1585	388/9376	1.37214218348564	TUBA1B/GAPDH/CALM1/TUBB/UQCRH/COX8C/TUBA1C/WNT7A/SLC25A4/AXIN2/TUBB4B/NDUFA4/BACE2/COX6C/NDUFS5/PSMA7/PSMB1/FZD3/WNT10B/UQCR10/NDUFA6/PSMB5/NDUFA11/LRP6/MME/SLC25A6/COX5A/NDUFV2/NOS2/PSMB6/DKK1/NDUFB10/PSMC3/NDUFB11/PSMB7/NAE1/PSMB2/COX5B/VDAC1/NDUFAB1/PSMA4/SDHA/SLC39A7/LRP5/COX7C/FZD1/NDUFA9/NDUFA12/NDUFS2/COX4I1/WIPI1/AKT2/CSNK2A2/NDUFS6/SDHC/CAPN1/NDUFA8/NDUFC1/UQCRC1/NDUFB4/PSMD3/CSNK2A1/BAD/NDUFS3/HRAS/SLC39A1/FRAT2/COX7A2L/PSMC5/PSMB4/PSMD4/FZD6/PSMA3/CASP3/PPID/PSMC4/APAF1/APP/NDUFC2/PSMA1/INSR/SLC39A10/NDUFA13/SLC39A4/PSMC6/CHRM5/VDAC2/GRIN2D/CSNK1A1/PLCB3	3.3767343962327
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	59/1585	235/9376	1.48515739311363	RPS6/UQCRH/COX8C/NDUFA4/COX6C/NDUFS5/ADCY5/UQCR10/NDUFA6/NDUFA11/FGFR1/GNAS/COX5A/NDUFV2/ADCY6/NDUFB10/KDM1A/NDUFB11/COA5/CPT2/COX5B/NDUFAB1/SDHA/MAPK13/MAPK12/COX7C/ACTG1/NDUFA9/NDUFA12/NDUFS2/COX4I1/NDUFAF1/COA4/NDUFS6/SDHC/ACTL6A/ATF2/NDUFA8/NDUFC1/COA6/UQCRC1/NDUFB4/COX19/NDUFS3/HRAS/COX16/COX7A2L/COX20/COX11/COA1/COX17/TSC1/SMARCC1/NDUFC2/NDUFA13/SMARCE1/SMARCA4/AKT1S1/SMARCD1	3.39721786906185
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	17/1585	46/9376	2.18614730489645	PSMA7/PSMB1/PSMB5/PSMB6/PSMC3/PSMB7/PSMB2/PSMA4/PSMD3/PSMC5/PSMB4/PSMD4/PSMA3/PSMC4/POMP/PSMA1/PSMC6	3.63731061200187
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	39/1585	142/9376	1.62466788110366	UBE2C/CDC20/SKP2/RPS27A/UBA52/UBE2S/ANAPC11/UBB/SKP1/MID1/RBX1/NEDD4/SAE1/UBE2L3/UBA1/UBA3/BRCA1/UBE4B/UBE2F/UBE2Q2/ANAPC10/CUL4A/ANAPC13/PPIL2/CDC16/UBE2G1/RCHY1/HERC4/CDC27/HUWE1/UBE2E3/FZR1/UBE2J2/ANAPC4/HERC2/KLHL9/PIAS4/DDB1/PRPF19	3.38300066022786
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	38/1585	138/9376	1.628894070315	UQCRH/COX8C/ATP6V1C2/NDUFA4/ATP6V1B1/COX6C/PPA1/NDUFS5/UQCR10/NDUFA6/NDUFA11/COX5A/NDUFV2/NDUFB10/NDUFB11/COX5B/NDUFAB1/SDHA/COX7C/NDUFA9/NDUFA12/NDUFS2/COX4I1/NDUFS6/SDHC/NDUFA8/NDUFC1/ATP6V1E1/UQCRC1/NDUFB4/PPA2/NDUFS3/COX7A2L/COX11/COX17/LHPP/NDUFC2/NDUFA13	3.35684843942589
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	33/1585	116/9376	1.68284564342434	GCSH/PHGDH/GLDC/PSAT1/GAPDH/ACAT2/TPI1/ENO1/ALDOA/GPT2/SHMT1/RPIA/IDH2/ADH5/PGP/IDH1/SDHA/RPE/DLD/SDHC/IDH3B/PFKL/ESD/MDH2/PFKP/MCEE/DLST/GPI/HIBCH/PCCB/PGAM1/ACOX3/ALDH6A1	3.3377185585006
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1585	85/9376	1.80943403228799	TYMS/RRM2/TK1/AK5/DUT/IMPDH2/RRM1/AK1/DTYMK/NME1/AK3/GMPR2/PNP/NUDT16/HPRT1/NT5M/CTPS1/GMPS/ADA/DCTPP1/ADK/NT5C3B/AK2/DGUOK/ENPP1/UCKL1	3.38114162460298
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/1585	12/9376	3.45068349106204	VKORC1L1/COQ6/COQ7/COQ5/COQ3/GGCX/COQ4	3.83134106947171
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	14/1585	37/9376	2.23828118339159	UGP2/GNPNAT1/CMAS/GALK1/GMPPA/UXS1/PGM1/GALK2/GPI/TGDS/MPI/PMM2/PMM1/GMDS	3.40387510977755
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	15/1585	41/9376	2.16419173655459	GCSH/ALDH7A1/PHGDH/GLDC/PSAT1/ALAS2/GAMT/GCAT/SHMT1/CBS/CHDH/GRHPR/DLD/PGAM1/SRR	3.36948051167588
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	23/1585	75/9376	1.81407360672976	PHGDH/PSAT1/GAPDH/ASS1/TPI1/ASNS/ENO1/ALDOA/ARG2/GPT2/SHMT1/RPIA/CBS/IDH2/IDH1/ASL/RPE/PYCR1/IDH3B/PFKL/PFKP/PGAM1/PYCR2	3.19251652130077
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1585	93/9376	1.71739086191106	RAC3/ARHGAP29/PARD3/CDH5/YES1/CDH1/ERBB2/TCF7L2/FGFR1/TJP1/PTPRF/MYL12B/ACP1/WASF1/EGFR/MET/MYL9/ACTG1/CSNK2A2/HEG1/LMO7/KRIT1/CSNK2A1/CTNNA1/WASL/INSR/FER	3.13586103451691
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	20/1585	63/9376	1.87792298833308	ALDH7A1/ACAT2/AADAT/EZH2/HYKK/AASS/DHTKD1/SUV39H2/SETD7/DLD/SMYD2/PLOD1/EHMT2/PLOD2/EHMT1/DLST/SMYD3/SETD1A/SUV39H1/GCDH	3.15344719957591
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/1585	39/9376	2.12349753296126	GCSH/TYMS/ALDH7A1/GLDC/DHFR/SHMT1/CBS/CHDH/MTHFD1L/ATIC/DLD/AHCYL1/MTHFD2L/MTHFS	3.17105968660116
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	81/1585	362/9376	1.32362444882096	CCNE1/PGF/RPS6/LAMA4/EFNA1/COL4A2/COL4A1/YWHAE/LAMB1/IGF2/CDK2/ERBB3/GNG12/COL9A3/ERBB2/PTK2/COL1A1/ANGPT1/HSP90AB1/GHR/IGF1/GNG4/FGFR1/FLT4/LAMA5/MAGI1/CCNE2/ITGB4/COL1A2/COL6A3/LAMC1/PKN3/FGFR3/LAMA1/EGFR/MET/COL6A2/YWHAQ/GNG2/PRKCA/CCND3/OSMR/PTEN/PPP2CB/PPP2R3A/LPAR6/BRCA1/GNB5/GNG11/ITGA1/LAMC2/IL2RB/FLT1/AKT2/CDC37/F2R/ATF2/LAMA2/FGF7/PHLPP1/EFNA5/BAD/CCND2/HRAS/ITGA9/PPP2CA/CDKN1B/PDGFRB/GNG10/TSC1/ITGB8/EFNA4/TP53/IL2RA/INSR/GYS1/MYC/LAMB2/PPP2R5D/PPP2R3B/PPP2R2A	2.8323081463288
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	40/1585	157/9376	1.50712290783419	CCNE1/CCNB1/HLA-G/CDK1/CCNB2/CCNA2/CALM1/RRAS2/SLC25A4/CDK2/MYBL2/CHEK1/CDC25A/FOXM1/IGFBP3/SLC25A6/E2F5/CCNE2/VDAC1/CCND3/MAPK13/MAPK12/PTEN/E2F1/ETS1/NFATC2/AKT2/E2F2/CAPN1/GADD45A/CCND2/HRAS/PPID/LIN9/TSC1/TP53/MYC/VDAC2/MAP2K6/RAD1	2.8901795050739
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	40/1585	157/9376	1.50712290783419	BIRC5/YAP1/TEAD4/ID1/BMP7/PARD3/WNT7A/BMP4/DLG5/YWHAE/AXIN2/CDH1/PRKCZ/BMP2/TEAD3/TEAD1/PARD6B/RASSF6/FZD3/DLG3/WWTR1/TCF7L2/WTIP/WNT10B/FRMD6/AMOT/TEAD2/YWHAQ/CCND3/FZD1/PPP2CB/ACTG1/CCND2/CTNNA1/PPP2CA/FZD6/WWC1/MYC/PPP2R2A/DLG1	2.8901795050739
NA	NA	hsa04518	Integrin signaling	39/1585	154/9376	1.4980703838748	PGF/FERMT2/RAC3/LAMA4/PARVA/FERMT1/COL4A2/COL4A1/LAMB1/CDH1/COL9A3/ERBB2/PTK2/COL1A1/IGF1/FLT4/LAMA5/ITGB4/COL1A2/COL6A3/LAMC1/FLNB/LAMA1/EGFR/MET/COL6A2/CCND3/ACTG1/ITGA1/LAMC2/FLT1/AKT2/LAMA2/CCND2/NCK2/ITGA9/PDGFRB/ITGB8/LAMB2	2.81087924891079
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	53/1585	224/9376	1.399639477242	CCNE1/HLA-G/PTTG1/CDC20/CCNB2/MAD2L1/SLC2A1/CCNA2/RANBP1/MSX2/RAN/SLC25A4/CDK2/CHEK1/ANAPC11/BUB1B/FDPS/ADCY5/SLC25A6/CCNE2/IL1R1/NFYB/ADCY6/NRP1/VDAC1/CCND3/PTEN/BUB3/E2F1/EGR2/KAT5/ETS1/NFATC2/RANBP3/IL2RB/AKT2/ANAPC10/E2F2/GPS2/ATF2/ESPL1/ANAPC13/CDC16/CCND2/HRAS/CDC27/ANAPC4/TP53/IL2RA/MYC/XPO1/VDAC2/DLG1	2.73047405962722
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	31/1585	117/9376	1.56734341718569	MTA3/RBBP7/MORF4L2/MORF4L1/CECR2/SMARCA1/RUVBL1/ACTG1/KAT5/ACTR6/BCL7C/BCL7A/RUVBL2/ACTL6A/PHF6/ACTR8/ZNHIT1/MCRS1/PHF10/BAZ1B/CDK2AP1/SMARCC1/HDAC1/BRD9/SMARCE1/CDK2AP2/SMARCA4/YY1/DMAP1/SMARCD1/ARID2	2.78522688273006
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/1585	54/9376	1.86227363009697	PHGDH/LDHB/PSAT1/ADI1/LDHA/DNMT3B/CDO1/CBS/SRM/DNMT1/TST/CISD1/GSS/AHCYL1/MDH2/MRI1/MTAP	2.86609845290681
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	18/1585	59/9376	1.80471582099129	RRM2/GSTA4/PRDX6/GSTP1/GPX8/GPX3/GGCT/RRM1/GSTO2/IDH2/MGST3/HPGDS/SRM/IDH1/ODC1/GSS/GSR/GSTM3	2.79662455907042
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	29/1585	110/9376	1.55952968167479	CCNB1/CDK1/CCNB2/MAD2L1/CCNA2/GNAI1/AURKA/PLK1/CDK2/ANAPC11/CDC25A/PKMYT1/HSP90AB1/CDC25C/ADCY5/IGF1/BUB1/ADCY6/MAPK13/MAPK12/AKT2/ANAPC10/MAD2L2/ANAPC13/CDC16/CDC27/FZR1/ANAPC4/KIF22	2.66242261556675
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	48/1585	203/9376	1.39872884648257	PGF/CAV1/RAC3/LAMA4/PARVA/COL4A2/COL4A1/LAMB1/CAV2/COL9A3/ERBB2/PTK2/COL1A1/IGF1/FLT4/LAMA5/ITGB4/COL1A2/MYL12B/COL6A3/LAMC1/PAK6/EMP2/FLNB/LAMA1/EGFR/MET/COL6A2/PAK4/PRKCA/CCND3/PTEN/MYL9/ACTG1/ITGA1/LAMC2/FLT1/AKT2/LAMA2/BAD/CRK/CCND2/HRAS/ITGA9/DOCK1/PDGFRB/ITGB8/LAMB2	2.5904406576072
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/1585	78/9376	1.6684623473267	CAV1/CTTN/CDH1/CAV2/PTK2/ARPC1A/CLTA/WASF1/MET/ACTG1/DNM2/CLTC/ARPC5L/MAD2L2/CLTB/CRK/ELMO3/CTNNA1/ACTR3B/DOCK1/WASL/CD2AP	2.67382604539123
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/1585	23/9376	2.31474420518447	ACAT2/FDPS/HMGCS1/DHDDS/FNTA/IDI1/RCE1/PDSS1/PDSS2	2.84730103149239
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1585	44/9376	1.88219099512475	CDK7/GTF2F1/GTF2E2/GTF2B/ERCC3/GTF2E1/TAF9B/TAF2/TAF8/TAF9/GTF2H3/ERCC2/TAF6L/TAF4B	2.64548475344026
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1585	29/9376	2.03981290112042	YAP1/TEAD4/TEAD3/TEAD1/RASSF6/WWTR1/WTIP/FRMD6/TEAD2/WWC1	2.52942466062637
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	21/1585	78/9376	1.59262314972094	LSM7/LSM3/LSM4/HSPD1/ENO1/EXOSC8/LSM2/LSM5/EXOSC1/NUDT16/LSM1/EXOSC4/PFKL/TOB2/BTG3/DIS3L/PFKP/DIS3/CNOT7/EXOSC2/PARN	2.3704719034103
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/1585	227/9376	1.32902347169916	GSTA4/UQCRH/COX8C/SLC25A4/NDUFA4/COX6C/SOD1/PTK2/NDUFS5/GSTO2/UQCR10/NDUFA6/NDUFA11/SLC25A6/COX5A/NDUFV2/MGST3/ACP1/NDUFB10/NDUFB11/EGFR/COX5B/MET/VDAC1/NDUFAB1/SDHA/MAPK13/MAPK12/PTEN/COX7C/NDUFA9/NDUFA12/NDUFS2/COX4I1/AKT2/NDUFS6/SDHC/NDUFA8/NDUFC1/UQCRC1/NDUFB4/BAD/NDUFS3/HRAS/SLC26A2/COX7A2L/GSTM3/NDUFC2/ABL1/NDUFA13/VDAC2	2.26337578186255
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	37/1585	157/9376	1.39408868974663	LEP/UQCRH/COX8C/NDUFA4/COX6C/NDUFS5/UQCR10/NDUFA6/NDUFA11/COX5A/NDUFV2/NDUFB10/NDUFB11/COX5B/NDUFAB1/SDHA/MAPK13/MAPK12/COX7C/NDUFA9/GSK3A/NDUFA12/NDUFS2/COX4I1/AKT2/NDUFS6/SDHC/NDUFA8/NDUFC1/UQCRC1/NDUFB4/NDUFS3/COX7A2L/CASP3/NDUFC2/INSR/NDUFA13	2.24597831549651
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	26/1585	103/9376	1.49322225965514	LAMA4/COL4A2/COL4A1/LAMB1/ARG2/PTK2/COL1A1/GNAS/LAMA5/NOS2/COL1A2/IL1R1/LAMC1/CD1C/COL3A1/LAMA1/SERPINB9/PRKCA/CD14/C9/LAMC2/LAMA2/SERPINB6/CASP3/LAMB2/PLCB3	2.27015139144177
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	23/1585	89/9376	1.52871371353631	HMMR/LAMA4/COL4A2/COL4A1/LAMB1/COL9A3/COL1A1/GP9/DAG1/LAMA5/ITGB4/COL1A2/COL6A3/LAMC1/LAMA1/COL6A2/ITGA1/LAMC2/LAMA2/SDC1/ITGA9/ITGB8/LAMB2	2.2603803589178
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/1585	128/9376	1.43264984227129	RRM2/AK5/PAICS/IMPDH2/RRM1/AK1/ADCY5/PPAT/ADCY6/NME1/PDE4C/AK3/GMPR2/ATIC/NUDT5/PNP/NUDT16/HPRT1/NT5M/GMPS/FHIT/PDE4D/PGM1/ADA/ADK/NUDT2/AK2/PDE9A/HDDC3/DGUOK/ENPP1	2.22290699926714
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	20/1585	75/9376	1.57745531019979	TOP2A/BIRC5/GSTA4/GSTP1/ERBB2/GSTO2/MSH2/ATP7B/MGST3/MSH6/BRCA1/XPA/AKT2/MSH3/BAD/CASP3/APAF1/GSTM3/TP53/TOP2B	2.26458099474741
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1585	71/9376	1.58300973030613	SLC2A1/LDHB/LDHA/ERBB2/FGFR1/IDH2/FGFR3/EGFR/MET/IDH1/PTEN/AKT2/PFKL/HRAS/PFKP/PDGFRB/PGAM1/TP53/MYC	2.22408027293619
NA	NA	hsa03272	Virion - Hepatitis viruses	14/1585	48/9376	1.72534174553102	CLDN4/EPCAM/CLDN6/CLDN10/CLDN7/CLDN3/LDLR/CLDN19/DPP4/EGFR/CHMP1A/TSG101/VPS4A/OCLN	2.27233675050074
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	11/1585	35/9376	1.85914375844975	AKR1B1/TPI1/ALDOA/GMPPA/PFKL/PFKP/MPI/PMM2/PMM1/GMDS/KHK	2.29671361433813
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/1585	53/9376	1.67418606035355	CLTA/GNAS/RAB11A/ADCY6/ATP2B3/ATP1A4/PRKCA/AP2A2/DNM2/CLTC/PTH1R/CLTB/AP2A1/AP2M1/PLCB3	2.21995172645704
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1585	86/9376	1.51325654757538	DSP/DSG2/PKP2/SGCE/JUP/TCF7L2/SGCB/DSC2/DAG1/ITGB4/LAMA1/DMD/ACTG1/ITGA1/GJA1/EMD/LAMA2/ITGA9/CTNNA1/CACNB3/CACNB4/ITGB8	2.15664933729666
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/1585	31/9376	1.90821206879007	GCSH/GLDC/ACAT2/SHMT1/PGP/GRHPR/DLD/MDH2/MCEE/PCCB	2.28445249882031
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	7/1585	19/9376	2.17937904698655	GCSH/GLDC/DHTKD1/DLD/LIPT2/DLST/LIAS	2.32094881477261
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1585	142/9376	1.37471897631848	CAV1/GSTA4/RAC3/GSTP1/CALM1/BMP4/GPC1/CDH5/PRKCZ/MMP2/CAV2/ASS1/PTK2/HSP90AB1/GSTO2/MGST3/IL1R1/ACVR2B/SUMO2/MAPK13/MAPK12/ACTG1/TXN2/TXN/AKT2/MEF2C/CCL2/SDC1/MAP2K5/GSTM3/TP53/PIAS4/MAP2K6	2.02935765169422
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	40/1585	178/9376	1.32931627264027	RAC3/WNT7A/AXIN2/APCDD1/TLE1/LGR4/FZD3/TCF7L2/SKP1/WNT10B/LRP6/NOTUM/RNF43/DKK1/CACYBP/RBX1/PRKCA/RUVBL1/CTNNBIP1/CCND3/LRP5/FZD1/TLE2/TBL1XR1/NFATC2/CBY1/CSNK2A2/CTBP2/CSNK2A1/CCND2/FRZB/FRAT2/FZD6/TP53/SFRP1/CAMK2G/MYC/MCC/CSNK1A1/PLCB3	2.00069164752175
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	38/1585	170/9376	1.32227871590276	GSTA4/GSTP1/WNT7A/AXIN2/IGF2/FZD3/TCF7L2/WNT10B/GSTO2/LRP6/MGST3/EGFR/MET/TXNRD2/PRKCA/LRP5/PTEN/FZD1/E2F1/ACTG1/AKT2/E2F2/ACTL6A/GADD45A/BAD/HRAS/FRAT2/PHF10/FZD6/GSTM3/SMARCC1/TP53/SMARCE1/MYC/SMARCA4/SMARCD1/ARID2/CSNK1A1	1.91260051892061
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1585	20/9376	2.07041009463722	SQLE/FDFT1/DHCR24/TM7SF2/MSMO1/DHCR7/NSDHL	2.16134331264618
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/1585	20/9376	2.07041009463722	UGP2/CMAS/GMPPA/CYB5R1/TGDS/CYB5R2/GMDS	2.16134331264618
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1585	110/9376	1.39819902494981	SLC2A1/LDHB/GAPDH/RPS6/LDHA/ENO1/ALDOA/ERBB2/EGLN3/ANGPT1/IGF1/NOS2/RBX1/EGFR/PRKCA/FLT1/AKT2/MKNK2/PFKL/PFKP/EGLN1/CDKN1B/INSR/CAMK2G/EPAS1/MKNK1	1.89475933850316
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1585	38/9376	1.71236925120372	UGP2/GNPNAT1/GALK1/GMPPA/UXS1/PGM1/GALK2/GPI/MPI/PMM2/PMM1	1.98460324928504
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/1585	103/9376	1.37835900891244	RBM8A/MSI2/SAP18/ALYREF/MAGOHB/PAPOLA/PPP2CB/PPP2R3A/FUS/MAGOH/NCBP2/ACIN1/UPF3A/PABPN1/PPP2CA/UPF3B/UPF2/SYMPK/WDR33/NXT1/PPP2R5D/PPP2R3B/PPP2R2A/CSTF1	1.74147093674901
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	32/1585	144/9376	1.31454609183316	SLC25A4/PSMA7/PSMB1/PSMB5/SLC25A6/VLDLR/PSMB6/PSMC3/PSMB7/PSMB2/VDAC1/PRKCA/PSMA4/NOP56/KAT5/GTF2B/OPA1/WIPI1/ATXN2/AKT2/AFG3L2/PSMD3/PSMC5/PSMB4/PSMD4/PSMA3/PSMC4/PSMA1/PSMC6/VDAC2/GRIN2D/PLCB3	1.71562083178476
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1585	83/9376	1.42541142487933	AURKB/EZH2/RBBP7/SKP1/CBX3/PCGF2/TFDP1/SCML2/SFMBT2/USP16/WDR5/PCGF1/MTF2/BAP1/L3MBTL2/HDAC1/HCFC1/FBRSL1/SUZ12/YY1	1.75579535632708
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1585	59/9376	1.50392985082607	TYMS/RRM2/TK1/DUT/RRM1/DTYMK/NME1/NT5M/CTPS1/UMPS/DCTPP1/NUDT2/NT5C3B/ENPP1/UCKL1	1.75130469677214
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	67/1585	333/9376	1.19019713720029	CCNE1/HLA-G/CCNA2/LAMA4/PARD3/WNT7A/COL4A2/COL4A1/AXIN2/ATP6V1C2/LAMB1/CDK2/PRKCZ/ATP6V1B1/PARD6B/COL9A3/PTK2/COL1A1/FZD3/DLG3/TCF7L2/WNT10B/HEY1/GNAS/LAMA5/MAGI1/CCNE2/ITGB4/COL1A2/COL6A3/LAMC1/CRB3/LAMA1/EGFR/COL6A2/CCND3/PTEN/FZD1/PPP2CB/PPP2R3A/E2F1/ITGA1/LAMC2/AKT2/LAMA2/ATP6V1E1/BAD/CCND2/HRAS/ITGA9/TUBG1/PPP2CA/CDKN1B/FZD6/CASP3/PDGFRB/TSC1/ITGB8/TP53/HDAC1/LAMB2/TLR3/PPP2R5D/PPP2R3B/PPP2R2A/CSNK1A1/DLG1	1.59394560432999
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/1585	50/9376	1.5380189274448	ALDH7A1/CKMT1B/CKMT1A/GAMT/ARG2/CKB/NOS2/SRM/PYCR1/ODC1/L3HYPDH/PYCR2/OAT	1.7204359949243
Cellular Processes	Cell motility	hsa04814	Motor proteins	41/1585	194/9376	1.25017398939803	TPM1/TUBA1B/MYL4/MYO1B/TUBB/KIF2C/KIF23/TUBA1C/MYH10/KIF11/TUBB4B/TPM2/KIF4A/KIFC1/CENPE/MYO10/KIF15/KIF21A/KIF14/KIF20A/KIF18A/DNALI1/MYL12B/DYNLL2/TNNC1/DYNLL1/TNNT3/KIF18B/MYL9/ACTG1/MYH9/TPM4/DCTN6/KIF20B/TUBG1/DYNC1LI2/MYO7A/MYO15B/DYNC2LI1/DYNLRB1/KIF22	1.58810072545732
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/1585	27/9376	1.75272812244421	ELOVL6/FADS2/ELOVL2/ACOT4/FADS1/SCD/ACOX3/TECR	1.76661174472504
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1585	184/9376	1.25381977780826	RAC3/GNAI1/ENAH/EFNA1/BMP7/PARD3/EPHB4/PRKCZ/PARD6B/PTK2/FZD3/CFL2/SEMA4C/ROBO1/SEMA6A/EPHB3/MYL12B/PAK6/RHOD/LRRC4/SEMA4B/NRP1/MET/PAK4/PRKCA/MYL9/FES/NFATC2/PLXNA2/EFNA5/SEMA7A/HRAS/NCK2/SEMA5A/EFNB2/EFNA4/ABL1/CAMK2G/RND1	1.56831404779654
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/1585	56/9376	1.4788643533123	TUSC3/MGAT3/DHRSX/GANAB/MAN1A2/B4GALT1/ALG14/OSTC/ALG8/MOGS/MGAT5/DOLK/TMEM258/DPM2	1.62107174424011
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	32/1585	149/9376	1.27043380687231	GNAI1/NDUFA4/GNG12/NDUFS5/ADCY5/GNG4/NDUFA6/NDUFA11/NDUFV2/ADCY6/NDUFB10/NDUFB11/GABRE/NDUFAB1/GNG2/PRKCA/MAPK13/MAPK12/GNB5/GNG11/NDUFA9/NDUFA12/NDUFS2/NDUFS6/NDUFA8/NDUFC1/NDUFB4/NDUFS3/GNG10/NDUFC2/NDUFA13/PLCB3	1.50081625541823
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/1585	15/9376	1.97181913774974	AK5/AK1/ACP1/AK2/NFS1	1.69892271675512
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	23/1585	105/9376	1.29576686194983	TPM1/TPM2/SGCE/SGCB/ADCY5/IGF1/GNAS/DAG1/ITGB4/ADCY6/TNNC1/LAMA1/DMD/ACTG1/TPM4/ADRB1/ITGA1/EMD/LAMA2/ITGA9/CACNB3/CACNB4/ITGB8	1.37462596153346
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1585	30/9376	1.57745531019979	IDH2/IDH1/SDHA/DLD/SDHC/IDH3B/MDH2/DLST	1.42879455907477
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1585	30/9376	1.57745531019979	TYMS/DHFR/FOLR1/ABCG2/SHMT1/GGH/FOLR2/ATIC	1.42879455907477
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1585	31/9376	1.52656965503205	ALDOA/RPIA/DERA/RPE/PFKL/PGM1/PFKP/GPI	1.32449612329362
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1585	41/9376	1.44279449103639	CDH1/MMP2/ERBB2/FGFR3/EGFR/E2F1/E2F2/HRAS/TP53/MYC	1.28156502178935
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/1585	130/9376	1.2285950012133	GNAI1/COL4A2/COL4A1/PRKCZ/MMP2/GNG12/RLN2/COL1A1/ADCY5/GNG4/GNAS/NOS2/COL1A2/ADCY6/COL3A1/EGFR/GNG2/PRKCA/MAPK13/MAPK12/GNB5/GNG11/AKT2/ATF2/HRAS/GNG10/PLCB3	1.18376400506006
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	42/1585	212/9376	1.17193024224749	PGF/RAC3/GNAI1/ENAH/CALM1/ID1/EFNA1/PARD3/CDH1/PRKCZ/PARD6B/ANGPT1/ADCY5/IGF1/FGFR1/GNAS/FLT4/MAGI1/ADCY6/FGFR3/EGFR/MET/PRKCA/MAPK13/MAPK12/ACTG1/FLT1/AKT2/F2R/RALB/PFN2/FGF7/EFNA5/KRIT1/CRK/HRAS/MAGI3/PDGFRB/EFNA4/INSR/MAP2K6/PLCB3	1.14204005059972
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1585	67/9376	1.3243561372946	ALDH7A1/LDHB/GAPDH/LDHA/TPI1/ENO1/ALDOA/ADH5/ALDH3B2/DLD/PFKL/PGM1/PFKP/GPI/PGAM1	1.20174320542063
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/1585	52/9376	1.36510555690366	CGA/CYP11A1/HSD3B1/CYP2J2/LDLR/ADCY5/IGF1/GNAS/ADCY6/HSD17B1/ACOT4/INSR	1.19075565215945
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	23/1585	110/9376	1.23686836822483	ID1/BMP7/BMP4/BMP2/ID4/LRRC32/GREM2/SKP1/E2F5/ZFYVE9/RBX1/TFDP1/ACVR2B/PPP2CB/LTBP1/DCN/FST/ID3/PPP2CA/RGMB/HDAC1/SMAD5/MYC	1.12709606143957
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1585	32/9376	1.4788643533123	LDHB/LDHA/DLD/MCEE/HIBCH/PCCB/ACOX3/ALDH6A1	1.2238403081241
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1585	13/9376	1.82014074253822	FEN1/XRCC5/XRCC6/XRCC4	1.33461567359897
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/1585	204/9376	1.15989361044102	CAV1/RPS6/RRAS2/WNT7A/GPC1/CTTN/IGF2/MMP2/ERBB3/CAV2/EZR/ERBB2/PTK2/COL1A1/FZD3/ANK3/WNT10B/IGF1/FGFR1/COL1A2/EGFR/MET/PRKCA/MAPK13/MAPK12/FZD1/ACTG1/LUM/DCN/AKT2/NUDT16L1/SDC1/HRAS/FZD6/ANK1/CASP3/TP53/CAMK2G/MYC/GPC3	1.04140063727143
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	27/1585	133/9376	1.200882332013	GNAI1/CALM1/GNG12/ADCY5/GNG4/GNAS/SLC18A2/GNG2/PRKCA/MAPK13/MAPK12/PPP2CB/PPP2R3A/GNB5/GNG11/GSK3A/AKT2/ATF2/PPP2CA/GNG10/LRTOMT/COMT/CAMK2G/PPP2R5D/PPP2R3B/PPP2R2A/PLCB3	1.05236102349794
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/1585	106/9376	1.22773644425927	CCNE1/GSTP1/CDK2/FOLR1/ERBB2/HSP90AB1/TCF7L2/IGF1/FGFR1/CCNE2/EGFR/FOLR2/SPINT1/PTEN/E2F1/AKT2/E2F2/BAD/HRAS/CDKN1B/PDGFRB/TP53	1.06352883788196
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1585	18/9376	1.64318261479145	CD320/MMAA/MMADHC/HCFC1/ZNF143	1.23192054571816
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1585	33/9376	1.43405028199981	AADAT/GPT2/IDH2/DHTKD1/IDH1/DLD/IDH3B/DLST	1.12656825040072
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	39/1585	200/9376	1.1535141955836	CLDN4/CLDN6/CLDN10/TUBA1B/GAPDH/RPS3/CLDN7/MYO1B/TUBB/TUBA1C/NCKAP1/MYH10/BAIAP2L1/NCL/TUBB4B/CLDN3/CTTN/EZR/ARPC1A/MYO10/CLDN19/TJP1/IL1R1/WASF1/CYFIP2/MAPK13/MAPK12/NAIP/ACTG1/MYH9/ARPC5L/F2R/SEC24C/OCLN/NCK2/ACTR3B/CASP3/WASL/ABL1	0.989784175089741
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1585	59/9376	1.30340587071593	AXIN2/CDH1/ERBB2/TCF7L2/EGFR/PTEN/AKT2/GADD45A/BAD/HRAS/CTNNA1/TP53/MYC	1.05442478857328
NA	NA	hsa04382	Cornified envelope formation	42/1585	217/9376	1.14492724127404	KRT19/KRT7/KRT18/KRT8/DSP/KRT23/CLDN4/PKP3/CLDN6/CLDN10/CLDN7/DSG2/S100A13/PKP2/COL4A2/COL4A1/CLDN3/PRSS8/JUP/CLDN19/PADI1/TJP1/S100A16/LAMA5/KRT24/ITGB4/KRT80/KAZN/PCSK6/S100A1/PPP2CB/PPP2R3A/LAMC2/CAPN1/OCLN/SPTLC1/PPP2CA/KRT10/PPP2R5D/PPP2R3B/PPP2R2A/GBA2	0.974225587965572
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/1585	87/9376	1.22388774067225	TPM1/MYL4/UQCRH/COX8C/TPM2/COX6C/UQCR10/COX5A/TNNC1/COX5B/ATP1A4/COX7C/TPM4/COX4I1/UQCRC1/COX7A2L/CACNB3/CACNB4	0.946257049410687
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1585	83/9376	1.21159971114743	PRDX5/SOD1/SLC27A2/PXMP2/IDH2/NOS2/IDH1/ECH1/ACOT8/PEX10/PHYH/ECI2/DECR2/PEX19/ACOX3/PEX1/HACL1	0.873332892594958
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1585	10/9376	1.77463722397476	SELENBP1/TST/BPNT1	1.10541398594072
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/1585	105/9376	1.18309148264984	RPS27A/BNIP3/UBA52/RRAS2/UBB/TOMM20/TOMM7/PHB2/E2F1/SAMM50/OPA1/OPTN/CSNK2A2/FUNDC1/RHOT2/CSNK2A1/HRAS/HUWE1/MFN1/TP53/TBC1D17	0.850948289902811
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	28/1585	144/9376	1.15022783035401	DUSP9/DLX5/ID1/WNT7A/BMP4/AXIN2/ID4/LIFR/TBX3/FZD3/WNT10B/IGF1/FGFR1/PCGF2/MEIS1/FGFR3/ACVR2B/MAPK13/MAPK12/FZD1/AKT2/PCGF1/ID3/HRAS/IL6ST/FZD6/SMAD5/MYC	0.819383873972528
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1585	89/9376	1.19638464537625	CDK1/GNAI1/TUBA1B/TUBB/TUBA1C/TUBB4B/ADCY5/GNAS/TJP1/ADCY6/EGFR/PRKCA/ADRB1/GJA1/HRAS/MAP2K5/PDGFRB/PLCB3	0.83959236130351
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	10/1585	46/9376	1.28596900288026	ALAS2/CP/UROD/HMOX2/HCCS/UROS/HMBS/FECH/FXN/ALAD	0.876921512687484
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	29/1585	150/9376	1.14365509989485	CCNE1/WNT7A/AXIN2/CDH1/CDK2/ERBB2/JUP/FZD3/TCF7L2/WNT10B/LRP6/CCNE2/EGFR/MET/LRP5/FZD1/E2F1/AKT2/E2F2/GADD45A/FGF7/HRAS/FRAT2/CTNNA1/CDKN1B/FZD6/TP53/MYC/CSNK1A1	0.799951435676174
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/1585	73/9376	1.21550494792792	RAN/PSIP1/PPIA/MAP1B/CHMP6/SUPT5H/TSG101/VPS4A/NELFB/NELFE/PIN1/FEZ1/APOBEC3B/MLLT1/XPO1	0.833701983529314
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1585	73/9376	1.21550494792792	CDH1/IGF1/FGFR1/EGFR/MET/PTEN/E2F1/AKT2/E2F2/GADD45A/FGF7/BAD/HRAS/PDGFRB/TP53	0.833701983529314
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1585	57/9376	1.24535945542089	ELOVL6/ACAT2/FADS2/ELOVL2/FASN/CPT2/PPT2/FADS1/SCD/ACOX3/TECR/MCAT	0.838029371781948
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/1585	31/9376	1.33574844815305	SRP14/SGTA/SRP9/SRP19/SRP54/HSPA5/SRP72	0.84451793553028
NA	NA	hsa04981	Folate transport and metabolism	7/1585	31/9376	1.33574844815305	TYMS/DHFR/FOLR1/ABCG2/SHMT1/FOLR2/MTHFS	0.84451793553028
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	17/1585	86/9376	1.16933460494461	ERBB3/ERBB2/PTK2/PAK6/EGFR/PAK4/PRKCA/AKT2/BAD/CRK/HRAS/NCK2/NRG1/CDKN1B/ABL1/CAMK2G/MYC	0.711525971291293
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1585	37/9376	1.27901781908091	ASS1/ASNS/GPT2/PPAT/RIMKLA/RIMKLB/ASL/NIT2	0.766983963167904
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1585	37/9376	1.27901781908091	CDH1/TCF7L2/CCDC6/GADD45A/TPR/HRAS/TP53/MYC	0.766983963167904
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1585	32/9376	1.29400630914826	AKR1B1/UGP2/GALK1/PFKL/PGM1/B4GALT1/PFKP	0.751396025804784
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1585	99/9376	1.13528980658318	TPM1/TPM2/SGCE/SGCB/IGF1/DAG1/ITGB4/TNNC1/LAMA1/DMD/ACTG1/TPM4/ITGA1/EMD/LAMA2/ITGA9/CACNB3/CACNB4/ITGB8	0.610355080881301
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	25/1585	133/9376	1.11192808519722	CCNB1/CCNB2/SKP2/BNIP3/PLK1/CDK2/IGF1/FOXO6/FOXO4/PLK4/PRMT1/EGFR/HOMER1/MAPK13/MAPK12/PTEN/PLK2/SETD7/AKT2/GADD45A/CCND2/HRAS/CDKN1B/INSR/ATG12	0.586356963880177
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1585	17/9376	1.39187233252923	MYH10/DAG1/MYH9/CD209	0.729386982810144
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1585	44/9376	1.20997992543734	GNAS/DYNLL2/RAB11A/ADCY6/DYNLL1/RAB11B/DCTN6/DYNC1LI2/DYNC2LI1	0.629680754329679
NA	NA	hsa04519	Cadherin signaling	72/1585	404/9376	1.05423993503451	KRT19/KRT7/KRT18/KRT8/DSP/KRT23/RAC3/PKP3/ENAH/YAP1/TEAD4/MYO1B/DSG2/PKP2/RRAS2/NCKAP1/CIB2/WNT7A/YWHAE/AXIN2/CDH5/DSC3/CDH1/MPDZ/TEAD3/TEAD1/LIMA1/ERBB2/JUP/PTK2/ARPC1A/FZD3/WWTR1/TCF7L2/WTIP/WNT10B/DSC2/AMOTL2/FGFR1/LRP6/TJP1/FLT4/KRT24/PCDH12/KRT80/TMC5/WASF1/TEAD2/FAT2/AMOTL1/EGFR/GABRE/MET/YWHAQ/CYFIP2/MAPK13/MAPK12/LRP5/FZD1/ACTG1/GJA1/ARPC5L/HRAS/CTNNA1/ACTR3B/FZD6/PDGFRB/MYO7A/FMN1/KRT10/WWC1/CSNK1A1	0.502653695802403
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/1585	61/9376	1.16369654031132	MT1E/MT1G/MT1H/ATP7B/ATP2B3/SLC6A19/MT1F/MT1A/ATP1A4/HMOX2/SLC40A1/SLC39A4	0.578517709414515
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1585	28/9376	1.26759801712483	ST3GAL4/ST8SIA1/A4GALT/B3GNT3/B4GALT1/B4GALT4	0.639596714439011
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1585	28/9376	1.26759801712483	AKR1B1/DHFR/GGH/MOCS2/QDPR/MOCS1	0.639596714439011
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1585	23/9376	1.28596900288026	ASS1/ARG2/GPT2/NOS2/ASL	0.619314261789484
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1585	34/9376	1.21788829096307	POLR2H/POLR2L/POLR2F/POLR2I/POLR1E/POLR3H/POLR3F	0.574059738453671
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1585	62/9376	1.14492724127404	SOD1/CRYAB/ADCY5/IGF1/ADCY6/AKT2/HRAS/CLPB/EIF4EBP2/HDAC1/INSR/AKT1S1	0.516394279536426
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/1585	79/9376	1.12318811643972	ATP6V1C2/ATP6V1B1/CLTA/SLC18A2/SLC6A11/AP2A2/SYT1/DNM2/CLTC/CLTB/STX2/ATP6V1E1/AP2A1/SLC6A4/AP2M1	0.49592341541221
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	27/1585	148/9376	1.07917128484952	WNT7A/AXIN2/ERBB2/FZD3/TCF7L2/WNT10B/HEY1/IGF1/FGFR1/LRP6/FLT4/EGFR/LRP5/PTEN/FZD1/E2F1/BRCA1/AKT2/E2F2/GADD45A/FGF7/HRAS/FRAT2/FZD6/TP53/MYC/CSNK1A1	0.437873262591464
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1585	154/9376	1.07553771149986	TPM1/GNAI1/MYL4/CALM1/TPM2/ADCY5/GNAS/ADCY6/ATP2B3/TNNC1/ATP1A4/PRKCA/MAPK13/MAPK12/PPP2CB/PPP2R3A/TPM4/ADRB1/AKT2/ATF2/PPP2CA/CACNB3/CACNB4/CAMK2G/PPP2R5D/PPP2R3B/PPP2R2A/PLCB3	0.426299962092365
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1585	80/9376	1.10914826498423	RPS6/ERBB3/ERBB2/IGF1/FGFR3/EGFR/MET/PRKCA/PTEN/AKT2/GAS6/BAD/HRAS/NRG1/PDGFRB	0.442198680011025
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1585	63/9376	1.12675379299985	WNT7A/BMP4/AXIN2/BMP2/FZD3/TCF7L2/WNT10B/GLI3/FZD1/GADD45A/FZD6/TP53	0.455292091542033
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/1585	103/9376	1.09120088205568	COL4A2/COL4A1/COL21A1/COL9A3/COL1A1/COL27A1/DPP4/MME/COL1A2/COL6A3/SLC6A19/COL3A1/KCNK5/ATP1A4/COL6A2/COL5A2/COL5A1/COL16A1/COL14A1	0.419769800017096
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	21/1585	115/9376	1.08021396241942	GCM1/GNAI1/NACA/GATA3/MMP15/ADCY5/FGFR1/LRP6/GNAS/WNK2/ADCY6/PDE4C/EGFR/PRKCA/LRP5/MMP14/PTH1R/MEF2C/PDE4D/ATF2/PLCB3	0.390367467836915
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1585	75/9376	1.10421871713985	CGA/GPX8/GPX3/ADCY5/GNAS/ADCY6/ATP1A4/PRKCA/ASGR2/GSR/ATF2/TTF1/HSPA5/PLCB3	0.408709941640697
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1585	87/9376	1.08790021393089	BIRC5/RAC3/AXIN2/TCF7L2/MSH2/EGFR/MSH6/AKT2/RALB/GADD45A/MSH3/BAD/HRAS/CASP3/TP53/MYC	0.37150849272526
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1585	47/9376	1.13274716423921	ALDH7A1/LDHB/ACAT2/LDHA/ADH5/GRHPR/GLO1/DLD/MDH2	0.411490965163081
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	21/1585	116/9376	1.07090177308822	CLDN4/GNAI1/JAM3/CLDN6/CLDN10/CLDN7/CDH5/CLDN3/MMP2/EZR/PTK2/CLDN19/THY1/MYL12B/PRKCA/MAPK13/MAPK12/MYL9/ACTG1/OCLN/CTNNA1	0.346564653587583
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1585	70/9376	1.09858494817485	SLC2A1/EGLN3/PAK6/RBX1/MET/PAK4/ETS1/AKT2/BAD/CRK/HRAS/EGLN1/EPAS1	0.37340641755117
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/1585	70/9376	1.09858494817485	HLA-G/CAV1/RAC3/SGCE/SGCB/DAG1/LAMA1/DMD/ACTG1/EIF4G1/LAMA2/CASP3/ABL1	0.37340641755117
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	22/1585	122/9376	1.06672182861871	SLC2A1/DIO2/BMP4/MED12L/PLCD4/SLC16A2/ATP1A4/THRB/PRKCA/ACTG1/AKT2/PFKL/BAD/HRAS/PFKP/MED24/TP53/HDAC1/MYC/PLCD1/PLCB3/MED17	0.334569831321224
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1585	36/9376	1.15022783035401	GYG2/UGP2/PYGL/PGM1/GPI/ENPP1/GYS1	0.407316381194092
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1585	82/9376	1.08209586827729	RRM2/GSTA4/GSTP1/TK1/DUT/IMPDH2/RRM1/GSTO2/MGST3/NME1/HPRT1/UMPS/GMPS/GSTM3/UCKL1	0.336767801624767
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1585	48/9376	1.10914826498423	ALDH7A1/ACAT2/HMGCS1/DLD/MCEE/HIBCH/PCCB/ACAD8/ALDH6A1	0.341937597422407
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1585	37/9376	1.1191405916958	HBA2/HBA1/LAMA4/HBB/PRKCA/THOP1/PLCB3	0.32750210539963
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/1585	101/9376	1.05423993503451	COL4A2/COL4A1/PRKCZ/MMP2/COL1A1/COL1A2/PLCD4/COL3A1/PRKCA/MAPK13/MAPK12/AKT2/CCL2/HRAS/CDKN1B/CASP3/PLCD1/PLCB3	0.247187529914769
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	44/1585	253/9376	1.02877520230421	RPS27A/BNIP3/UBA52/CTTN/FNBP1L/PTK2/U2AF1/ARPC1A/UBB/SKP1/FOXO6/FOXO4/CBX3/MYL12B/IL1R1/PLCD4/RBX1/WASF1/EGFR/VDAC1/CD14/MAPK13/MAPK12/MYL9/NAIP/ACTG1/GSK3A/ARPC5L/WIPI1/AKT2/CAPN1/PFN2/TIFA/GLMN/CRK/ACTR3B/DOCK1/PPID/WASL/TP53/AKT1S1/ATG12/PLCD1/PLCB3	0.209273133943404
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1585	43/9376	1.10055021641846	ALDH7A1/ACAT2/ADH5/ECI1/CPT2/ECI2/ACOX3/GCDH	0.29806451371051
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	43/1585	248/9376	1.02566398697466	TUBA1B/GAPDH/RPS3/TUBB/TUBA1C/NCKAP1/TUBB4B/HSP90AB1/ARPC1A/TCF7L2/SKP1/MYL12B/DYNLL2/CSE1L/DYNLL1/CYFIP2/CD14/MAPK13/MAPK12/MYL9/EXOC7/NAIP/ACTG1/TXN2/DNM2/TXN/DCTN6/ARPC5L/AKT2/PFN2/GSDMD/PIK3C2B/HRAS/PIK3C2A/DYNC1LI2/ACTR3B/CASP3/FBXO22/WASL/DYNC2LI1/MYC/DYNLRB1/MAP2K6	0.184742076250429
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1585	32/9376	1.10914826498423	PPP2CB/IGBP1/WIPI1/ATG4D/PPP2CA/ATG12	0.278951743485467
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1585	38/9376	1.08968952349328	QPRT/NNMT/PNP/NT5M/NMRK1/ENPP1/NADK2	0.249867774964755
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/1585	214/9376	1.02276600135617	CCNB1/HLA-G/CDK1/CCNB2/WEE1/AP1M2/RAC3/GNAI1/CALM1/GNG12/CHEK1/PTK2/CDC25C/SKP1/CFL2/GNG4/PAK6/RBX1/PAK4/GNG2/PRKCA/MAPK13/MAPK12/GNB5/GNG11/NFATC2/AKT2/CUL4A/BAD/CRK/HRAS/AP1G2/CASP3/GNG10/APOBEC3B/DDB1/MAP2K6	0.151950512650904
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1585	50/9376	1.06478233438486	HBA2/HBA1/GYPA/GYPB/HBB/MET/GYPC/CCL2/SDC1	0.207156020402959
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/1585	174/9376	1.01990645056021	TUSC3/HSP90AB1/CRYAB/SKP1/BAG2/WFS1/RBX1/PDIA6/RRBP1/UBE4B/GANAB/SEC23B/PRKCSH/PREB/CAPN1/PLAA/MAN1A2/UBE2G1/BAG1/SEC24C/OSTC/MOGS/UGGT2/RAD23A/UBE2J2/CKAP4/HSPA4L/TMEM258/HSPA5/RAD23B	0.119544887758539
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1585	21/9376	1.12675379299985	DSEL/CHPF/XYLT1/CSGALNACT1	0.262272275861107
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1585	21/9376	1.12675379299985	PANK3/COASY/PANK1/ENPP1	0.262272275861107
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	21/1585	122/9376	1.01823447277241	LEP/CCNA2/FASN/IGF1/EEF2/CAB39L/PPP2CB/PPP2R3A/RAB11B/AKT2/PFKL/PFKP/PPP2CA/TSC1/SCD/INSR/GYS1/AKT1S1/PPP2R5D/PPP2R3B/PPP2R2A	0.0914349112725649
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1585	51/9376	1.04390424939692	ATP6V1C2/ATP6V1B1/GNAS/TJP1/PRKCA/ACTG1/KDELR3/ATP6V1E1/KDELR2	0.141798257432013
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	35/1585	205/9376	1.00995614372548	CCNE1/HLA-G/CDK1/CDC20/SKP2/CCNA2/RANBP1/YWHAE/CDK2/CHEK1/CCNE2/HNRNPK/YWHAQ/CCND3/EGR2/GTF2E2/GTF2B/SND1/ATF2/BAD/CCND2/HRAS/GTF2E1/SNW1/IL6ST/CDKN1B/CASP3/MRPS18B/TP53/HDAC1/DDB1/EGR3/HDAC11/GTF2H3/DLG1	0.0650074918943403
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1585	99/9376	1.01578561641653	MMP2/ERBB2/PTK2/ADCY5/IGF1/GNAS/ADCY6/EGFR/MAPK13/MAPK12/E2F1/AKT2/E2F2/BAD/HRAS/CDKN1B/TP53	0.0712162388875117
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1585	28/9376	1.05633168093736	ELOVL6/ELOVL2/PPT2/ACOT4/TECR	0.134640601725962
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/1585	76/9376	1.01185455752947	CALM1/IGF1/EGFR/PRKCA/PTEN/E2F1/AKT2/E2F2/GADD45A/HRAS/PDGFRB/TP53/CAMK2G	0.0468009145437607
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/1585	232/9376	0.994408789296204	RAC3/DIAPH3/ENAH/RRAS2/NCKAP1/MYH10/EZR/GNG12/PTK2/ARPC1A/CFL2/FGFR1/ITGB4/MYL12B/PAK6/WASF1/FGFR3/EGFR/PAK4/CYFIP2/MYL9/ACTG1/MYH9/C9/ITGA1/ARPC5L/AKT2/F2R/PFN2/FGF7/CRK/HRAS/ITGA9/ACTR3B/DOCK1/PDGFRB/ITGB8/WASL/CHRM5	-0.0388942509449834
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	40/1585	238/9376	0.994194523235162	PGF/RAC3/CALM1/PLA2G2A/EFNA1/RRAS2/IGF2/GNG12/ANGPT1/PLA2G10/RALBP1/IGF1/GNG4/FOXO4/FGFR1/FLT4/PAK6/FGFR3/EGFR/MET/PAK4/GNG2/PRKCA/GNB5/GNG11/ETS1/KSR1/FLT1/AKT2/RALB/FGF7/EFNA5/BAD/HRAS/RASGRF2/PDGFRB/GNG10/EFNA4/INSR/ABL1	-0.0409170638870632
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/1585	77/9376	0.998713589249867	E2F1/AKT2/E2F2/GADD45A/CTBP2/BAD/CRK/HRAS/CDKN1B/TP53/HDAC1/ABL1/MYC	-0.00511223216770999
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	26/1585	155/9376	0.992270275770835	CCNE1/CYP11A1/GNAI1/WNT7A/HSD3B1/AXIN2/CDK2/PBX1/LDLR/FZD3/TCF7L2/ADCY5/WNT10B/GNAS/CCNE2/ADCY6/EGFR/FZD1/E2F1/E2F2/ATF2/WDR5/CDKN1B/FZD6/CAMK2G/PLCB3	-0.0437667710731713
NA	NA	hsa04517	IgSF CAM signaling	50/1585	299/9376	0.98920692529251	JAM3/CNTNAP2/TUBA1B/TUBB/TUBA1C/PARD3/MYH10/TUBB4B/CLMP/CDH1/MPDZ/EZR/PARD6B/PTK2/ARPC1A/ANK3/ROBO1/FGFR1/TJP1/PTPRF/MAGI1/MYL12B/DYNLL2/PTPRS/PAK6/NLGN2/GRIP1/NRP1/DYNLL1/PAK4/PRKCA/MAPK13/MAPK12/MYL9/IL1RAP/ACTG1/MYH9/ARPC5L/AKT2/LMO7/PLXNA2/SPTBN1/NCK2/CD209/ACTR3B/ERC1/APP/WASL/ABL1/CD2AP	-0.0855486733153616
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/1585	156/9376	0.985909568874868	CLDN4/CLDN6/CLDN10/CLDN7/YWHAE/CLDN3/CDK2/LDLR/CLDN19/EIF3E/EGFR/YWHAQ/PPP2CB/E2F1/AKT2/E2F2/BAD/HRAS/OCLN/PPP2CA/CASP3/APAF1/TP53/MYC/TLR3/PPP2R2A	-0.0800432638926116
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1585	42/9376	0.985909568874868	ALDH7A1/ACAT2/AADAT/DHTKD1/DLD/DLST/GCDH	-0.0412780048420254
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1585	30/9376	0.985909568874868	PIGC/PIGS/PGAP1/PIGO/DPM2	-0.0348638777252564
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/1585	73/9376	0.972403958342336	ERBB2/EGFR/MET/PRKCA/E2F1/AKT2/FHIT/E2F2/GADD45A/BAD/HRAS/TP53	-0.106757988105438
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1585	24/9376	0.985909568874868	HS6ST2/EXTL2/GLCE/XYLT1	-0.0311731954510388
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1585	37/9376	0.959263364310683	MIF/ADH5/ALDH3B2/FAHD1/LRTOMT/COMT	-0.111979752368644
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1585	31/9376	0.954106034395034	ALDH7A1/ALDH3B2/HIBCH/ACOX3/ALDH6A1	-0.11543843999641
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1585	93/9376	0.954106034395034	CGA/CALM1/MMP2/ADCY5/GNAS/ADCY6/EGFR/PRKCA/MAPK13/MAPK12/MMP14/HRAS/CAMK2G/MAP2K6/PLCB3	-0.200611836728294
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1585	76/9376	0.934019591565665	GNAI1/GAST/CALM1/EZR/ADCY5/GNAS/ADCY6/ATP1A4/PRKCA/ACTG1/CAMK2G/PLCB3	-0.260485762460651
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1585	89/9376	0.930521390848191	GNAI1/SLC38A1/GNG12/ADCY5/GNG4/ADCY6/SLC6A11/GABRE/GNG2/PRKCA/GNB5/GNG11/GNG10/SLC38A5	-0.297038036787918
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1585	163/9376	0.943569894137911	CCNE1/BIRC5/CCNA2/PCNA/CDK2/CCNE2/YWHAQ/PRKCA/MAPK13/MAPK12/E2F1/EGR2/NFATC2/AKT2/E2F2/ATF2/BAD/HRAS/CASP3/APAF1/TP53/MYC/DDB1/EGR3/TLR3/MAP2K6	-0.327799133270925
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1585	26/9376	0.91007037126911	PLA2G2A/FADS2/PLA2G10/ACOX3	-0.207103452255711
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1585	77/9376	0.921889466999877	RAC3/RAD51/ERBB2/RALBP1/EGFR/E2F1/AKT2/E2F2/RALB/GADD45A/BAD/TP53	-0.310413434743831
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1585	158/9376	0.935990097033103	SKP2/RPS6/WNT7A/ATP6V1C2/ATP6V1B1/FZD3/WNT10B/IGF1/PRR5/LRP6/CAB39L/PRKCA/LRP5/PTEN/FZD1/AKT2/MIOS/ATP6V1E1/HRAS/FZD6/TSC1/INSR/AKT1S1/DEPDC5/SLC38A9	-0.365983098557414
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1585	78/9376	0.91007037126911	ISYNA1/TPI1/IMPA2/INPP4B/PLCD4/PTEN/PIK3C2B/PIK3C2A/ALDH6A1/INPP5A/PLCD1/PLCB3	-0.359715374418089
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1585	97/9376	0.914761455657095	GNAI1/CALM1/GNG12/ADCY5/GNG4/GNAS/ADCY6/GNG2/PRKCA/GNB5/GNG11/GNG10/CAMK2G/GRIN2D/PLCB3	-0.380605424367933
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/1585	227/9376	0.938134215317056	HLA-G/RAC3/GNAI1/CALM1/GNG12/PTK2/ADCY5/GNG4/GNAS/CCL4L2/IL1R1/ADCY6/CCL4L1/EGFR/GNG2/PRKCA/MAPK13/MAPK12/CCL3L1/E2F1/GNB5/GNG11/NFATC2/AKT2/E2F2/ATF2/CCL2/CRK/HRAS/CASP3/GNG10/TSC1/TP53/MYC/MAP2K6/PLCB3	-0.425579117666505
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1585	91/9376	0.91007037126911	GNAI1/GNG12/ADCY5/GNG4/GNAS/ADCY6/PDE4C/GABRE/GNG2/PRKCA/GNB5/GNG11/PDE4D/GNG10	-0.388808912830062
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1585	60/9376	0.887318611987382	RAC3/PTK2/PRKCA/MAPK13/MAPK12/NFATC2/AKT2/BAD/HRAS	-0.394926923951526
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1585	14/9376	0.845065344749887	B4GALT1/B4GALT4	-0.261656747639465
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/1585	112/9376	0.897881928796755	GNAI1/LAMA4/LAMB1/LDLR/LAMA5/NOS2/LAMC1/LAMA1/MAPK13/MAPK12/LAMC2/AKT2/LAMA2/BAD/CASP3/LAMB2/MAP2K6	-0.490361100156936
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/1585	125/9376	0.89914952681388	RAC3/GNAI1/PRKCZ/FCER1A/PRKCA/MAPK13/MAPK12/PTEN/PPP2CB/PPP2R3A/AKT2/HRAS/SPTLC1/PPP2CA/TP53/PPP2R5D/PPP2R3B/PPP2R2A/PLCB3	-0.511967362066431
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1585	42/9376	0.845065344749887	CP/GSS/SLC7A11/TP53/SLC40A1/VDAC2	-0.453882027655276
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1585	300/9376	0.926754994742377	PGF/STMN1/DUSP9/RAC3/EFNA1/RRAS2/IGF2/ERBB3/GNG12/ERBB2/ANGPT1/IGF1/FGFR1/FLT4/IL1R1/FGFR3/EGFR/MET/PRKCA/CD14/MAPK13/MAPK12/IL1RAP/DAXX/FLT1/AKT2/MKNK2/MEF2C/ATF2/GADD45A/MAP3K13/FGF7/EFNA5/CRK/HRAS/MAP2K5/RASGRF2/CASP3/PDGFRB/CACNB3/CACNB4/EFNA4/TP53/INSR/MYC/MAP2K6/MKNK1	-0.581560722697872
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/1585	101/9376	0.878533279195427	GNAI1/CALM1/WNT7A/FZD3/TCF7L2/ADCY5/WNT10B/GNAS/ADCY6/PRKCA/FZD1/HRAS/FZD6/CAMK2G/PLCB3	-0.553560004513724
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1585	56/9376	0.845065344749887	BNIP3/EEF1A1/HSPD1/CD14/NAIP/HSF1/CASP3/APAF1	-0.524491309683559
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1585	63/9376	0.845065344749887	PTGDS/PLA2G2A/CYP2J2/PTGES3/PTGES/PLA2G10/HPGDS/LTC4S/PTGES2	-0.556516073970671
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/1585	115/9376	0.874458921958579	GNAI1/CYP2J2/GNG12/ADCY5/GNG4/GNAS/SLC18A2/GNG2/PRKCA/GNB5/GNG11/HRAS/CASP3/GNG10/SLC6A4/APP/PLCB3	-0.610955390637585
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1585	23/9376	0.771581401728158	CHST10/B4GALT1/POMGNT1	-0.49467912306197
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1585	122/9376	0.87277240523349	GNAI1/PTK2/GHR/ADCY5/IGF1/IGFBP3/GNAS/ADCY6/PRKCA/MAPK13/MAPK12/SOCS2/AKT2/ATF2/CRK/HRAS/MAP2K6/PLCB3	-0.637969848873412
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1585	90/9376	0.854454959691553	ADCY5/IGF1/ADCY6/AKT2/ATF2/EHMT2/EHMT1/HRAS/SESN1/TSC1/TP53/INSR/AKT1S1	-0.625760283075894
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1585	44/9376	0.806653283624892	TUSC3/MAN1A2/B4GALT1/ALG14/OSTC/TMEM258	-0.579801645136669
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1585	16/9376	0.739432176656151	MIF/ALDH3B2	-0.470485801182948
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1585	16/9376	0.739432176656151	ST8SIA1/A4GALT	-0.470485801182948
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1585	71/9376	0.833163015950593	CGA/ELF5/MAPK13/MAPK12/SOCS2/AKT2/CCND2/CISH/HRAS/TNFRSF11A	-0.636453948762776
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1585	71/9376	0.833163015950593	JAM3/ATP6V1C2/ATP6V1B1/TJP1/EGFR/MET/MAPK13/MAPK12/ATP6V1E1/CASP3	-0.636453948762776
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1585	65/9376	0.819063334142199	CYP11A1/HSD3B1/PBX1/LDLR/ADCY5/GNAS/ADCY6/ATF2/PLCB3	-0.660220138809219
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1585	38/9376	0.778349659638054	SFN/IGF1/ATP1A4/PRKCA/INSR	-0.617499962195387
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/1585	98/9376	0.845065344749887	CYP11A1/CALM1/HSD3B1/LDLR/ADCY5/GNAS/ADCY6/ATP2B3/ATP1A4/PRKCA/ATF2/ATF1/CAMK2G/PLCB3	-0.695405455096112
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1585	59/9376	0.802095920440571	CGA/GNAI1/ADCY5/GNAS/ADCY6/ADRB1/AKT2/INSR	-0.68777498192386
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1585	99/9376	0.836529331166555	CALM1/CYP2J2/ADCY5/IGF1/GNAS/IL1R1/ADCY6/PRKCA/MAPK13/MAPK12/IL1RAP/CAMK2G/MAP2K6/PLCB3	-0.737492024103173
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1585	17/9376	0.695936166264613	TXNRD2/SEPHS1	-0.565950142074393
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1585	32/9376	0.739432176656151	BIRC5/CASP3/APAF1/HTRA2	-0.665936821153167
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1585	60/9376	0.788727655099895	GNAI1/IGF1/GNAS/PRKCA/PPP2CB/HRAS/PPP2CA/PLCB3	-0.74046955543431
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1585	107/9376	0.829269730829329	SLC2A1/LDHB/CALM1/LDHA/GNAS/PYGL/PRMT1/AKT2/ATF2/PFKL/PFKP/PGAM1/CAMK2G/GYS1/PLCB3	-0.801105368469692
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1585	140/9376	0.845065344749887	GNAI1/MYL4/RPS6/CALM1/RRAS2/CDH1/GNG12/ADCY5/GNG4/NOS2/ADCY6/TFAM/GNG2/GNB5/GNG11/AKT2/MEF2C/HRAS/GNG10/PLCB3	-0.833056188834944
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1585	33/9376	0.717025140999904	STX2/GOSR2/STX17/USE1	-0.734455211830198
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1585	18/9376	0.657273045916579	FASN/MCAT	-0.656442457549437
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/1585	68/9376	0.78292818704769	CCNA2/JUP/TCF7L2/RUNX1T1/CD14/AKT2/BAD/HRAS/MYC	-0.810276739357589
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/1585	193/9376	0.858201075497295	RAC3/GNAI1/CXCL14/PARD3/CCR7/PRKCZ/GNG12/PTK2/ADCY5/GNG4/CCL4L2/ADCY6/CCL4L1/GNG2/CCL3L1/CX3CR1/CXCR6/GNB5/GNG11/GSK3A/CCL21/AKT2/CCL2/BAD/CRK/HRAS/GNG10/PLCB3	-0.897765616866203
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1585	26/9376	0.682552778451832	SLC19A3/SLC5A6/SLC52A3	-0.731065127471455
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1585	69/9376	0.771581401728158	CALM1/ADCY5/GNAS/SLC18A2/PRKCA/ATF2/HDAC1/CAMK2G/GRIN2D	-0.858924161901649
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1585	83/9376	0.78397628368363	POLR2H/POLR2L/CCL4L2/CCL4L1/POLR2F/DDX41/GSDMD/ZCCHC3/CASP3/POLR3H/POLR3F	-0.891592034869279
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/1585	201/9376	0.853473955145409	CCNA2/HMGA2/MYCN/PBX1/JUP/PTK2/ETV4/ETV1/IGF1/IGFBP3/SIX4/MEIS1/MET/SPINT1/RUNX1T1/CD14/FUS/IL2RB/FLT1/MEF2C/GADD45A/CCND2/ATF1/CDKN1B/MLLT1/TP53/HDAC1/EWSR1/MYC	-0.947138495642035
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1585	49/9376	0.724341724071332	GNAI1/ADCY5/GNAS/SLC18A2/ATF2/GRIN2D	-0.872572971911773
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/1585	137/9376	0.820391904027263	BIRC5/TUBA1B/TUBA1C/LMNB1/CTSV/LMNB2/PARP1/ACTG1/DAXX/AKT2/CAPN1/DAB2IP/GADD45A/BAD/HRAS/CASP3/APAF1/HTRA2/TP53	-0.955162752225846
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	26/1585	183/9376	0.840447501335953	RAN/POP7/NHP2/FBL/NOP56/UTP6/GNL2/NMD3/NOP58/CSNK2A2/RIOK2/UTP18/CSNK2A1/WDR36/LSG1/SNORD3B-1/RPP25/GNL3/EMG1/BMS1/POP5/NXT1/RPP38/XPO1/IMP4/TBL3	-0.98311470907837
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/1585	98/9376	0.78470353441061	ARPC1A/MYO10/CFL2/ASAP3/WASF1/BIN1/PRKCA/DNM2/ARPC5L/AKT2/CRK/ACTR3B/DOCK1	-0.966332137842773
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	19/1585	138/9376	0.8144470351575	RPS6/CALM1/PRKCZ/FASN/PYGL/PTPRF/EXOC7/SOCS2/AKT2/MKNK2/PRKAR2B/BAD/CRK/HRAS/TSC1/INSR/GYS1/INPP5A/MKNK1	-0.990426225755965
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/1585	105/9376	0.788727655099895	PARP1/CCL4L2/IL1R1/EDARADD/CCL4L1/PPP1R13L/CD14/CCL21/CSNK2A2/GADD45A/CSNK2A1/ERC1/TNFRSF11A/PIAS4	-0.981923560804462
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1585	78/9376	0.758391976057591	GNAI1/CALM1/C1R/CFL2/NOS2/C1S/CD14/MAPK13/MAPK12/CASP3	-0.966423658379953
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1585	28/9376	0.633799008562415	ATP6V1C2/ATP6V1B1/ATP6V1E1	-0.875271623700135
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/1585	205/9376	0.836820804801108	CCNE1/HLA-G/SKP2/CCNA2/CDK2/CCNE2/PSMC3/NEDD4/CCND3/MAPK13/MAPK12/E2F1/AKT2/E2F2/GADD45A/PSMD3/CCND2/SNW1/PSMC5/PSMD4/CDKN1B/CASP3/PSMC4/APAF1/TP53/HDAC1/MYC/PSMC6/MAP2K6	-1.0654597303647
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1585	36/9376	0.657273045916579	AKR1B1/DCXR/UGP2/RPE	-0.929243951310274
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1585	36/9376	0.657273045916579	GALNT2/C1GALT1C1/GALNT1/B3GNT3	-0.929243951310274
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1585	51/9376	0.695936166264613	PLA2G2A/PLA2G10/GDPD3/PAFAH1B3/CHPT1/ENPP2	-0.982039833592972
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/1585	100/9376	0.769009463722398	CXCL14/CCR7/CCL4L2/IL20RA/CCL4L1/CCL3L1/CX3CR1/CCL21/IL2RB/CCL2/IL6ST/IL2RA/TNFRSF10D	-1.04741185826682
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1585	12/9376	0.492954784437434	CD209	-0.792702593194567
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/1585	115/9376	0.771581401728158	GNAI1/GNG12/ADCY5/GNG4/ADCY6/GNG2/PRKCA/GNB5/GNG11/AKT2/HRAS/GNG10/CAMK2G/CHRM5/PLCB3	-1.11161681987484
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/1585	136/9376	0.78292818704769	CCNE1/CDK2/CCNE2/EIF3H/CCND3/IL2RB/AKT2/CSNK2A2/CSNK2A1/BAD/RCHY1/CCND2/CD209/CDKN1B/CASP3/APAF1/TP53/IL2RA	-1.15011315597571
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/1585	116/9376	0.764929837920157	GNAI1/SLC38A1/GNG12/ADCY5/GNG4/GNAS/ADCY6/HOMER1/GNG2/PRKCA/GNB5/GNG11/GNG10/GRIN2D/PLCB3	-1.14901229886893
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1585	30/9376	0.591545741324921	PLA2G2A/CYP2J2/PLA2G10	-1.01063616892528
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1585	22/9376	0.537768855749928	ALDH7A1/ALDH3B2	-0.978983858001418
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/1585	90/9376	0.723000350508237	BATF3/EGFR/MAPK13/MAPK12/PTEN/NFATC2/AKT2/CSNK2A2/CSNK2A1/HRAS/MAP2K6	-1.19093978544749
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1585	69/9376	0.685850134869474	RAC3/FCER1A/PRKCA/MAPK13/MAPK12/AKT2/HRAS/MAP2K6	-1.18130008528301
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1585	139/9376	0.766030456391984	KRT19/KRT18/KRT23/GNAI1/CALM1/MMP2/HSP90AB1/ADCY5/GNAS/KRT24/ADCY6/FKBP4/EGFR/AKT2/ATF2/HRAS/KRT10/PLCB3	-1.25344397036094
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/1585	62/9376	0.667874224076524	TLE1/HEY1/TLE2/DTX4/CTBP2/SNW1/HDAC1	-1.18340657881687
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1585	23/9376	0.514387601152105	MME/THOP1	-1.0516758154877
Organismal Systems	Immune system	hsa04611	Platelet activation	16/1585	126/9376	0.751169195333233	GNAI1/PRKCZ/COL1A1/ADCY5/GP9/GNAS/COL1A2/MYL12B/ADCY6/COL3A1/MAPK13/MAPK12/ACTG1/AKT2/F2R/PLCB3	-1.26830066297716
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/1585	160/9376	0.776403785488959	HLA-G/CLDN4/JAM3/CNTNAP2/CLDN6/CLDN10/CLDN7/CDH5/CLDN3/CDH1/CLDN19/CD34/PTPRF/PTPRS/NLGN2/LRRC4/CD276/SDC1/OCLN/ITGA9/ITGB8	-1.28663948247867
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/1585	169/9376	0.770059544920016	HMGB1/RPS27A/BNIP3/UBA52/RRAS2/UBB/EIF2AK4/PTEN/PPP2CB/IGBP1/OPTN/WIPI1/AKT2/GORASP2/BAD/HRAS/ATG4D/PPP2CA/TSC1/STX17/AKT1S1/ATG12	-1.36051500701331
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/1585	196/9376	0.78470353441061	HLA-G/RPS27A/CALM1/UBA52/GNG12/UBB/TCF7L2/GNG4/GNG2/MAPK13/MAPK12/E2F1/GNB5/GNG11/NFATC2/AKT2/CD200R1/E2F2/HRAS/IL6ST/CASP3/GNG10/TP53/MYC/TLR3/MAP2K6	-1.37387513855708
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1585	79/9376	0.673912869863834	GSTA4/GSTP1/GSTO2/MGST3/HPGDS/ADH5/ALDH3B2/GSTM3/AKR7A2	-1.31274223498839
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/1585	122/9376	0.727310337694575	PAK6/PAK4/MAPK13/MAPK12/PPP2CB/PPP2R3A/NFATC2/AKT2/HRAS/NCK2/PPP2CA/PPP2R5D/PPP2R3B/PPP2R2A/DLG1	-1.36737460901939
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1585	15/9376	0.394363827549947	ST8SIA1	-1.05876598998299
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	20/1585	157/9376	0.753561453917097	SLC2A1/PBX1/ARG2/PTK2/TIMD4/TYRO3/TMEM30B/RAB17/MAPK13/MAPK12/GULP1/CX3CR1/ODC1/NFATC2/GAS6/CRK/SLC16A1/DOCK1/CASP3/CAMK2G	-1.4044950921087
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1585	65/9376	0.637049259888377	CGA/PRKCA/KISS1R/KISS1/AKT2/HRAS/PLCB3	-1.32437163513187
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	45/1585	323/9376	0.82413493373441	CCNE1/TPM1/STMN1/IGF2BP1/HMGA2/CDCA5/KIF23/TRIM71/EFNA1/FSCN1/ERBB3/EZR/EZH2/DNMT3B/ERBB2/CDC25A/CDC25C/FZD3/CCNE2/HNRNPK/FGFR3/DNMT1/EGFR/MET/TP63/PAK4/PRKCA/PTEN/E2F1/BRCA1/E2F2/MDM4/EFNA5/CRK/CCND2/HRAS/CDKN1B/CASP3/PDGFRB/EFNA4/TP53/HDAC1/ABL1/MYC/CCNG1	-1.4507355393793
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1585	73/9376	0.648269305561557	GSTA4/GSTP1/GSTO2/MGST3/HPGDS/ADH5/ALDH3B2/GSTM3	-1.36070461695177
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/1585	103/9376	0.689179504456219	GNAI1/GNAS/NOS2/MAPK13/MAPK12/CCL3L1/PPP2CB/AKT2/CCL2/PPP2CA/PPP2R2A/PLCB3	-1.43061179140758
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1585	43/9376	0.550275108209229	ACAT2/PLA2G2A/PLA2G10/AGPAT1	-1.33313518309366
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/1585	180/9376	0.755864002804066	HLA-G/SRSF3/SRSF2/SRSF7/SRSF9/ALYREF/SRPK1/DAXX/AKT2/EIF2B5/CCL2/BAD/CFP/EIF2B3/EIF2B4/CASP3/SRSF5/APAF1/TSC1/TP53/HCFC1/POU2F1/TLR3	-1.49166829922529
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/1585	52/9376	0.568793982043193	LIPG/LDLR/VDAC1/MYLIP/VDAC2	-1.40633576624176
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/1585	216/9376	0.766818553569342	CALM1/HSPA2/CYP2J2/HSPD1/LDLR/PTK2/HSP90AB1/VLDLR/PRKCA/CD14/MAPK13/MAPK12/CCL3L1/NFATC2/AKT2/CCL2/BAD/HRAS/HSPA4/CASP3/APAF1/TP53/HSPA5/CAMK2G/POU2F1/MAP2K6/MIB1/PLCB3	-1.56378412481754
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/1585	105/9376	0.67605227579991	CALM1/RRAS2/IL17D/MAPK13/MAPK12/EGR2/NFATC2/KSR1/AKT2/HRAS/CD209/EGR3	-1.50560123243511
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/1585	98/9376	0.663979913732054	CALM1/IMPA2/INPP4B/PLCD4/PRKCA/PTEN/PIK3C2B/PIK3C2A/INPP5A/PLCD1/PLCB3	-1.5081855033361
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1585	27/9376	0.438182030611053	ACAT2/HMGCS1	-1.31855605433906
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1585	76/9376	0.622679727710443	SLC27A6/FABP7/FADS2/SLC27A2/HMGCS1/CPT2/SCD/ACOX3	-1.4896324704783
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1585	17/9376	0.347968083132307	ACOT8	-1.21361870451666
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1585	17/9376	0.347968083132307	CDO1	-1.21361870451666
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/1585	149/9376	0.714619016365676	RRAS2/ADCY5/FCER1A/GNAS/ADCY6/EGFR/PRKCA/LPAR6/DNM2/AGPAT1/AKT2/F2R/RALB/HRAS/PDGFRB/TSC1/INSR/PLCB3	-1.58376803617552
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1585	69/9376	0.60011886801079	GNAI1/CALM1/ADCY5/GNAS/ADCY6/ADRB1/PLCB3	-1.50367600866438
NA	NA	hsa04081	Hormone signaling	28/1585	219/9376	0.756314189821817	CGA/LEP/GNAI1/GAST/DIO2/IGF2/GNG12/GHR/ADRA2C/ADCY5/IGF1/GNG4/RAMP1/GNAS/ADCY6/SLC16A2/RAMP2/THRB/GNG2/GNB5/ADRB1/GNG11/PTH1R/GNG10/INSR/SMAD5/SLC40A1/PLCB3	-1.64580872594074
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1585	18/9376	0.32863652295829	GBA2	-1.28589679197197
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1585	86/9376	0.619059496735383	SLC2A1/ADCY5/GNAS/ADCY6/ATP1A4/PRKCA/ATF2/CAMK2G/PLCB3	-1.60067141431729
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1585	38/9376	0.467009795782832	UNG/RFXANK/ADA	-1.48486769935553
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1585	166/9376	0.712705712439664	GNAI1/CALM1/SLC25A4/ADRA2C/ADCY5/SLC25A6/ADCY6/ATP2B3/VDAC1/ATP1A4/MYL9/ADRB1/NFATC2/AKT2/MEF2C/ATF2/BAD/INSR/VDAC2/PLCB3	-1.68443745183056
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/1585	56/9376	0.52816584046868	GLI3/IQCE/CCND2/GAS1/CSNK1A1	-1.59727283664539
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/1585	154/9376	0.691417100249908	GNAI1/CALM1/ADCY5/GNAS/EEF2/ADCY6/EGFR/PRKCA/MYL9/ACTG1/NFATC2/MEF2C/HRAS/MAP2K5/CACNB3/CACNB4/CAMK2G/PLCB3	-1.74149938956075
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1585	217/9376	0.736024655104741	BIRC5/GSTA4/GNAI1/CDC6/CDC25A/PTGES3/KPNA2/KLF5/HSP90AB1/ADCY5/GSTO2/GNAS/MGST3/ADCY6/EGFR/PRKCA/CCND3/E2F1/ADRB1/AKT2/ATF2/FGF7/BAD/HRAS/PAQR7/GSTM3/MYC	-1.77448720701664
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1585	49/9376	0.482894482714221	GALNT2/C1GALT1C1/GALNT1/B4GALT1	-1.63685380564009
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/1585	134/9376	0.6621780686473	CALD1/CALM1/PPP1R14A/PLA2G2A/MYH10/ADCY5/PLA2G10/RAMP1/GNAS/ADCY6/RAMP2/PRKCA/MYL9/MYH9/PLCB3	-1.77648247233902
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/1585	120/9376	0.640841219768665	CALM1/YWHAE/MAGED1/MAPK13/MAPK12/AKT2/BAD/CRK/HRAS/MAP2K5/TP53/ABL1/CAMK2G	-1.78594922367653
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/1585	67/9376	0.52974245491784	CALM1/PRKCA/HRAS/CAMK2G/GRIN2D/PLCB3	-1.74230959313401
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/1585	99/9376	0.597520950833254	RAC3/WASF1/EGFR/SLC44A2/PRKCA/AKT2/CHPT1/HRAS/PDGFRB/TSC1	-1.81576970809075
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/1585	138/9376	0.642984501440132	RAC3/PTK2/ARPC1A/MAPK13/MAPK12/ACTG1/NFATC2/ARPC5L/AKT2/CCL2/CRK/ACTR3B/DOCK1/WASL/MAP2K6	-1.90564194474162
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1585	93/9376	0.57246362063702	CALM1/ADCY5/GNAS/ADCY6/ATP2B3/ATP1A4/PRKCA/ADRB1/PLCB3	-1.8688482723509
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/1585	109/9376	0.596972766474691	SLC2A1/PRKCZ/SLC27A6/SLC27A2/PYGL/PTPRF/PTEN/AKT2/INSR/GYS1/TRIB3	-1.90889363664144
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1585	102/9376	0.579946805220511	PLA2G2A/ADCY5/PLA2G10/GNAS/RAB11A/ADCY6/ATP2B3/ATP1A4/PRKCA/PLCB3	-1.92386459142231
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1585	70/9376	0.507039206849932	GSTA4/GSTP1/GSTO2/MGST3/HPGDS/GSTM3	-1.86716864157467
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/1585	34/9376	0.347968083132307	SKP1/RBX1	-1.71787694513585
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1585	23/9376	0.257193800576053	ATP1A4	-1.60867250791342
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1585	45/9376	0.394363827549947	ABCG2/ABCA7/ABCB10	-1.83678209648409
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/1585	88/9376	0.537768855749928	TFPI/F13A1/C1R/SERPINB2/C1S/C9/F2R/CLU	-1.96491200505213
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1585	104/9376	0.568793982043193	PLA2G2A/PLA2G10/PEMT/AGPAT1/GPD1L/PCYT2/CHPT1/PISD/LYPLA2/PHOSPHO1	-1.99442835869305
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/1585	173/9376	0.649674513593844	SLC25A4/KPNA2/FDPS/SLC25A6/RAB11A/VDAC1/PRKCA/CCND3/ACTG1/RAB11B/AKT2/CCL2/NUP98/PABPN1/CASP3/APAF1/NXT1/XPO1/TLR3	-2.09765346373857
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/1585	82/9376	0.504978071862738	HLA-G/HSPA2/HSP90AB1/NFYB/RFXANK/HSPA4/HSPA5	-2.03064356334904
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1585	47/9376	0.377582388079737	PRKCZ/SOCS2/INSR	-1.9293762343732
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1585	254/9376	0.698676072431009	CALM1/SLC25A4/ERBB3/ERBB2/FGFR1/GNAS/SLC25A6/FLT4/NOS2/PLCD4/ATP2B3/TNNC1/FGFR3/EGFR/MET/VDAC1/PRKCA/ADRB1/NFATC2/MST1/FLT1/F2R/FGF7/PDGFRB/CAMK2G/CHRM5/PLCD1/VDAC2/GRIN2D/PLCB3	-2.19588257878282
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/1585	168/9376	0.633799008562415	HMGB1/SLC25A4/PPIA/HSP90AB1/PARP1/SLC25A6/PYGL/VDAC1/CHMP1A/CHMP4C/CHMP2B/CHMP6/VPS4A/CAPN1/PPID/CAMK2G/TLR3/VDAC2	-2.160206012988
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/1585	168/9376	0.633799008562415	LEP/LIFR/GHR/IL20RA/EGFR/CCND3/OSMR/SOCS2/IL2RB/AKT2/CCND2/CISH/HRAS/IL6ST/PDGFRB/IL2RA/MYC/PIAS4	-2.160206012988
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1585	66/9376	0.44814071312494	CYP11A1/HSD3B1/HSD17B1/LRTOMT/COMT	-2.02922008368837
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1585	100/9376	0.532391167192429	GYPA/GP9/CD34/MME/IL1R1/CD1C/CD14/ITGA1/IL2RA	-2.12034243655915
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1585	48/9376	0.369716088328076	ATP1A4/AKT2/PLCB3	-1.97454138627159
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/1585	109/9376	0.542702514976992	GATA3/HSP90AB1/IL1R1/MAPK13/MAPK12/IL1RAP/NFATC2/IL2RB/IL6ST/IL2RA	-2.16593864284791
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/1585	95/9376	0.498143782168355	ATP6V1C2/ATP6V1B1/ANGPT1/CCL3L1/FLT1/ATP6V1E1/CCL2/TNFRSF11A	-2.21741711302327
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1585	41/9376	0.288558898207279	GABRE/GRIN2D	-2.05909976202909
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1585	29/9376	0.203981290112042	CALM1	-1.93637658557712
NA	NA	hsa04082	Neuroactive ligand signaling	21/1585	199/9376	0.624244249639364	GNAI1/GNG12/ADRA2C/ADCY5/GNG4/GNAS/SLC18A2/ADCY6/SLC6A11/GABRE/GNG2/PRKCA/OGFRL1/GNB5/ADRB1/GNG11/GNG10/SLC6A4/CHRM5/GRIN2D/PLCB3	-2.41649264244727
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1585	72/9376	0.410795653697862	MAPK13/MAPK12/SIKE1/PIN1/ATG12	-2.26360689658226
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1585	90/9376	0.460091132141605	SLC2A1/ABCG2/LDLR/ADCY5/GNAS/ADCY6/ATP1A4	-2.32129879019069
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/1585	155/9376	0.57246362063702	HLA-G/TUBA1B/TUBB/TUBA1C/TUBB4B/ATP6V1C2/ATP6V1B1/C1R/COLEC12/MRC1/CD14/ACTG1/ATP6V1E1/CD209/DYNC1LI2	-2.42077029998449
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1585	31/9376	0.190821206879007	ALDH7A1	-2.03535119104979
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/1585	109/9376	0.488432263479293	CCL4L2/CCL4L1/CD14/MAPK13/MAPK12/CCL3L1/AKT2/TLR3/MAP2K6	-2.42298364905438
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1585	44/9376	0.268884427874964	HLA-G/HSPD1	-2.19244484442513
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/1585	65/9376	0.364028148507644	ALDH7A1/AKR1B1/LIPG/AGPAT1	-2.32059887961584
Human Diseases	Immune disease	hsa05310	Asthma	1/1585	32/9376	0.184858044164038	FCER1A	-2.08326966811112
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/1585	119/9376	0.497097261617581	MAPK13/MAPK12/MMP14/AKT2/DAB2IP/ATF2/CCL2/CASP3/RHBDF1/MAP2K6	-2.49015292385966
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/1585	250/9376	0.638869400630915	AP1M2/LAPTM4B/ATP6V1C2/CTSV/ATP6V1B1/CTSE/SLC29A2/CLTA/AP2A2/PPT2/VPS26A/OSBPL6/CLTC/CLTB/ATP6V1E1/AP3M1/BLOC1S5/AP5S1/AP1G2/AP2A1/AP3S2/AP4E1/STX17/AKT1S1/AP2M1/TLR3/SLC38A9	-2.61034391702746
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/1585	94/9376	0.440512786093026	TRAF4/HSP90AB1/IL17D/MAPK13/MAPK12/CCL2/CASP3	-2.45887799287017
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1585	99/9376	0.418264665583278	KRT19/KRT18/KRT23/C1R/KRT24/C1S/KRT10	-2.62447797108144
Human Diseases	Substance dependence	hsa05034	Alcoholism	18/1585	191/9376	0.557477661981601	GNAI1/CALM1/GNG12/ADCY5/PKIA/GNG4/SLC29A2/GNAS/SLC18A2/GNG2/GNB5/GNG11/ATF2/HRAS/GNG10/HDAC1/HDAC11/GRIN2D	-2.78686525375189
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/1585	91/9376	0.390030159115333	RAC3/IFITM1/NFATC2/AKT2/LILRA5/HRAS	-2.63719214724201
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/1585	144/9376	0.492954784437434	ALDH7A1/FASN/TCF7L2/ADH5/CD14/MAPK13/MAPK12/AKT2/CASP3/SCD/ACOX3/MAP2K6	-2.76556395727639
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1585	93/9376	0.381642413758014	GATA3/MAPK13/MAPK12/NFATC2/IL2RB/IL2RA	-2.7029664901622
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1585	39/9376	0.151678395211518	HLA-G	-2.39437859300607
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	16/1585	181/9376	0.522913362497168	CALM1/HSPD1/MRC1/NOS2/NFYB/CD14/MAPK13/MAPK12/KSR1/AKT2/BAD/RFXANK/CD209/CASP3/APAF1/CAMK2G	-2.92323912518946
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1585	54/9376	0.219091015305526	HLA-G/CGA	-2.59565172211303
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/1585	55/9376	0.215107542299971	SPTLC1/GBA2	-2.63307916058654
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/1585	78/9376	0.303356790423036	EEF1A1/NOS2/MAPK13/MAPK12	-2.78654851026554
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/1585	226/9376	0.549666396806343	CGA/RAC3/GNAI1/CALM1/RRAS2/ADCY5/GLI3/GNAS/ADCY6/ATP2B3/PDE4C/ATP1A4/MYL9/ADRB1/AKT2/F2R/PDE4D/BAD/ACOX3/CAMK2G/GRIN2D	-3.09087681162796
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/1585	70/9376	0.253519603424966	LEP/SLC2A1/AKT2	-2.82741509548574
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1585	45/9376	0.131454609183316	HLA-G	-2.63413695615651
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/1585	298/9376	0.575665318739017	LEP/CXCL14/BMP7/BMP4/CCR7/BMP2/LIFR/GHR/IL17D/CCL4L2/IL20RA/IL1R1/IL36RN/CCL4L1/GDF11/ACVR2B/OSMR/TNFRSF25/CCL3L1/CX3CR1/CXCR6/IL1RAP/CCL21/IL2RB/CCL2/IL6ST/IL2RA/TNFRSF11A/TNFRSF10D	-3.35757127449932
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1585	68/9376	0.173984041566153	ALDH1A3/ADH5	-3.08331841133217
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/1585	195/9376	0.455035185634555	HMGB1/SLC25A4/SLC25A6/VDAC1/PRKCA/MAPK13/MAPK12/ACTG1/AKT2/GSDMD/AZU1/HDAC1/HDAC11/VDAC2/PLCB3	-3.46852192645563
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/1585	142/9376	0.374923357177767	FHL2/IL1R1/MAPK13/MAPK12/NFATC2/AKT2/LILRA5/TNFRSF11A/MAP2K6	-3.38521438244033
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/1585	187/9376	0.442868469441117	YWHAE/HSP90AB1/VDAC1/MAPK13/MAPK12/NAIP/TXN2/TXN/GSDMD/CCL2/MFN1/ATG12/VDAC2/PLCB3	-3.47094781846916
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1585	86/9376	0.206353165578461	ADCY6/KCNK5/PLCB3	-3.33481945352373
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1585	66/9376	0.0896281426249881	GATA3	-3.34749255932753
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1585	143/9376	0.289567845403808	SNRPD1/SNRPB/SNRPD3/C1R/C1S/C9/SSB	-3.86120517785701
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/1585	133/9376	0.266862740447333	HLA-G/RAC3/PRKCA/NFATC2/HRAS/CASP3	-3.84068160248855
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	25/1585	370/9376	0.399693068462785	CGA/LEP/TMEM97/VGF/RLN2/GHR/ADRA2C/GZMA/CHRNA5/NPFFR2/GAL/GABRE/THRB/OGFRL1/LPAR6/ADRB1/KISS1R/PTH1R/KISS1/F2R/PGRMC1/NPW/CHRM5/CHRNB1/GRIN2D	-5.31388214453448
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1585	449/9376	0.0395242143424223	CALM1/NCALD/CAMK2G	-9.40720250165293