category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	90/1477	158/9376	3.61595090972978	PRKDC/MYC/PTTG1/MAD2L1/ORC6/SMC1A/CDK1/MCM7/TFDP1/CCNB2/FBXO5/MCM4/CCNA2/PCNA/CCNB1/ANAPC15/CCND3/SMC3/HDAC2/ESCO2/NDC80/CDC27/DBF4/CHEK1/MCM3/MCM5/BUB3/RAD21/CCNE1/TFDP2/YWHAH/CDT1/MCM6/ANAPC5/CDC20/AURKB/YWHAQ/HDAC1/ATRX/PLK1/YWHAB/CDC6/PDS5B/CDCA5/TTK/YWHAE/BUB1/MCM2/CDC45/RBL1/CDC25A/BUB1B/PPP2R1B/STAG2/PKMYT1/SKP2/TRIP13/PPP2R5E/E2F4/CDC7/CDKN2C/CDKN1C/PDS5A/CDK7/ORC1/CDK2/STAG1/ORC2/E2F3/MAD1L1/CHEK2/E2F1/CDC23/CDK6/DDX11/CDC25C/CUL1/E2F2/CCNH/TICRR/GSK3B/ORC5/CDC25B/E2F5/ANAPC4/HDAC8/ESPL1/MTBP/ATM/CCNE2	14.3393547909425
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	30/1477	36/9376	5.2900022568269	MCM7/MCM4/FEN1/RPA3/PCNA/RNASEH2B/RNASEH2A/MCM3/POLD2/MCM5/RFC4/RFC1/MCM6/PRIM1/RFC3/POLE3/LIG1/RFC5/RFC2/MCM2/RPA1/RPA2/POLD3/DNA2/POLA2/POLD1/POLE2/PRIM2/POLA1/POLE	11.1512913263883
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	55/1477	108/9376	3.23277915694977	ALYREF/KPNB1/RAN/KPNA2/NUP37/IPO5/TPR/PNN/XPO1/NUP107/CSE1L/RNPS1/NUP50/MAGOHB/THOC2/ACIN1/IPO7/AAAS/NUP54/KPNA3/IPO9/NUP62/RANGAP1/KPNA6/THOC1/SEH1L/NUP93/NUP155/NUP88/AHCTF1/THOC6/NUP160/NMD3/SENP2/NUP43/THOC5/NUP210/NUP205/NCBP1/XPO6/IPO8/NDC1/SNUPN/UPF1/XPO7/NUP85/TMEM33/XPO5/NUP35/NUP188/NUP153/TNPO3/DDX39B/TNPO2/NUP133	10.0914706972413
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	28/1477	44/9376	4.03963808703145	HMGB1/FEN1/PCNA/POLD2/APEX1/PARP1/RFC4/RFC1/RFC3/POLE3/LIG1/RFC5/RFC2/TDG/UNG/POLD3/MPG/POLD1/POLE2/SMUG1/TDP1/NEIL3/POLE/XRCC1/OGG1/NEIL2/PARP2/LIG3	8.73877745859101
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	30/1477	54/9376	3.52666817121793	UBE2T/RPA3/BRCA2/USP1/FANCI/RMI2/RAD51C/FANCD2/BRCA1/RPA1/RPA2/FANCB/RAD51/BLM/MLH1/FANCA/RMI1/FANCL/ERCC4/REV1/FANCE/FANCM/TELO2/BRIP1/EME1/FANCG/FANCF/FANCC/TOP3A/ATRIP	8.05156621900877
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	18/1477	23/9376	4.96800211945483	RPA3/PCNA/POLD2/RFC4/RFC1/MSH2/MSH6/RFC3/LIG1/RFC5/RFC2/RPA1/RPA2/POLD3/MLH1/POLD1/MSH3/EXO1	8.23853849360808
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	25/1477	41/9376	3.87073335865383	RPA3/POLD2/BRCA2/TOPBP1/RAD50/RAD51C/BRCA1/RPA1/RPA2/RAD51/BLM/POLD3/POLD1/XRCC2/RBBP8/NBN/BARD1/BRIP1/EME1/RAD54L/XRCC3/BRCC3/ATM/RAD54B/TOP3A	7.96558088791235
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	29/1477	63/9376	2.92209648472343	RPA3/PCNA/POLD2/RFC4/RFC1/RFC3/POLR2H/POLE3/LIG1/RAD23B/RFC5/MNAT1/RFC2/RPA1/DDB1/GTF2H5/RPA2/POLD3/POLD1/POLE2/CDK7/ERCC4/POLE/CETN2/CCNH/GTF2H2/ERCC3/ERCC8/POLR2M	6.61897112704065
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	42/1477	116/9376	2.29841477365583	GAPDH/PKLR/GCSH/PGK1/HK1/ACAT2/ENO1/ADH5/CAT/PCCB/PDHA1/PGP/FH/PDHB/DLD/MDH2/ESD/SUCLG1/MDH1/GOT2/RPIA/IDH2/PRPS1/CS/SHMT1/PRPS2/PFKL/SDHC/SUCLA2/GPI/SHMT2/OGDH/DLAT/ACAT1/PHGDH/IDH1/PFKP/SUCLG2/PSPH/GLDC/GPT2/HIBCH	6.08452638274986
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	42/1477	117/9376	2.27877020294082	HDAC2/RBBP7/RUVBL1/SMARCA5/YEATS4/BAZ1A/BAZ1B/HDAC1/POLE3/SMARCC1/RUVBL2/CHD4/ACTL6A/BRD7/SMARCA4/DPF3/RBBP4/MCRS1/UCHL5/SMARCB1/PHF6/BPTF/MBD3/ARID1A/MBD2/PBRM1/BRD9/ACTR6/SMARCD1/MTA1/MTA3/GATAD2A/ING3/DMAP1/ARID1B/NFRKB/MRGBP/ARID2/EP400/SMARCA2/BCL7A/MTA2	6.01856875017008
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	16/1477	30/9376	3.38560144436922	PDHA1/FH/PDHB/DLD/MDH2/SUCLG1/MDH1/IDH2/CS/SDHC/SUCLA2/ACLY/OGDH/DLAT/IDH1/SUCLG2	5.65894479177082
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	21/1477	48/9376	2.77725118483412	HSD17B10/ACAT2/PCCB/HADHA/HADH/DLD/ACADM/ABAT/HMGCS1/ALDH9A1/ALDH7A1/ACAT1/IVD/ACAD8/OXCT1/BCKDHB/ACAA2/MCCC2/DBT/MCCC1/HIBCH	5.33783311149939
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	47/1477	157/9376	1.90035749863081	HLA-G/MYC/CDK1/CCNB2/MYBL2/CCNA2/CCNB1/CCND3/VDAC3/CALM3/CHEK1/VDAC1/CCNE1/RAD50/PPP1CA/RBL1/CDC25A/RBBP4/SLC25A5/PPP1CC/PIK3R1/FOXM1/E2F4/KRAS/PPID/CDK2/PIK3R3/E2F3/NBN/CHEK2/E2F1/HUS1/PPP3CA/CDK6/HIPK2/AKT1/RAF1/LIN9/E2F2/NFATC2/BTRC/MTOR/AKT2/E2F5/PIK3CB/ATM/CCNE2	4.91940676025106
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	61/1477	224/9376	1.72869716607022	HLA-G/MYC/PTTG1/MAD2L1/RANBP1/CCNB2/TLN1/CCNA2/ANAPC15/CCND3/VDAC3/EGR1/CDC27/CHEK1/RAN/BUB3/FDPS/VDAC1/CCNE1/TBPL1/ANAPC5/CDC20/CALR/XPO1/SLC25A5/BUB1B/STAT5B/PIK3R1/NFYB/KRAS/CDKN2C/TCF3/CDK2/BCL2L1/PIK3R3/E2F3/MAD1L1/CHEK2/E2F1/CDC23/CREB1/IL1R1/DLG1/KAT2B/PPP3CA/AKT1/E2F2/NFATC2/IL15RA/ELK4/AKT2/ATF6B/ADCY7/PIK3CB/ETS2/ANAPC4/RANBP3/ESPL1/ATM/CCNE2/IL2RB	4.7731261537852
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/1477	78/9376	2.27877020294082	HSPD1/LSM5/LSM2/LSM6/ENO1/LSM4/DHX36/EXOSC8/DCP2/PABPC1/PABPC4/EXOSC9/XRN2/EXOSC3/EXOSC7/CNOT7/PNPT1/EXOSC10/CNOT10/CNOT6/MPHOSPH6/EXOSC2/DCPS/PFKL/NUDT16/DIS3/DIS3L/PFKP	4.90382391681977
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	17/1477	39/9376	2.76707810357099	DHFR/TYMS/GCSH/ATIC/MTHFD1/GART/DLD/AHCY/MTR/MTHFD1L/SHMT1/MTHFD2L/CBS/MTHFS/SHMT2/ALDH7A1/GLDC	4.78161052186063
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	22/1477	59/9376	2.36705185729204	DUT/TYMS/RRM2/TK1/DTYMK/NME4/NME1/NT5DC4/RRM1/HDDC2/CTPS1/UMPS/DCTPP1/NUDT2/UCK2/NT5C3B/DHODH/DCTD/NME1-NME2/UCK1/NME7/ENTPD5	4.55473145535779
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	41/1477	142/9376	1.83287402137946	UBE2C/ANAPC15/CDC27/ANAPC5/CDC20/UBE2N/UBE2S/UBE2E3/UBA2/BRCA1/DDB1/HERC2/HUWE1/SKP2/UBE3C/UBE3A/CUL2/FBXW7/TRIP12/UBA1/CBLB/CDC23/FANCL/UBA6/KEAP1/BIRC6/TRIM37/CUL1/UBA3/UBE2O/BTRC/UBE2Q2/FBXO4/KLHL9/ANAPC4/HERC3/ERCC8/NEDD4/PPIL2/PIAS2/UBE3B	4.32432555325133
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/1477	56/9376	2.38050101557211	RPN2/DDOST/OSTC/MAN2A1/STT3B/MAGT1/RPN1/GANAB/MAN1A2/TUSC3/STT3A/ALG8/DOLPP1/SRD5A3/B4GALT1/ALG6/FUT8/ALG14/ALG9/DHRSX/ALG1	4.48035696156572
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	14/1477	31/9376	2.866839932732	GCSH/ACAT2/CAT/PCCB/GRHPR/PGP/DLD/MDH2/MDH1/CS/SHMT1/SHMT2/ACAT1/GLDC	4.50181978083892
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	20/1477	54/9376	2.35111211414529	LDHB/LDHA/DNMT1/SRM/AHCY/MPST/MDH2/SMS/ADI1/MDH1/MTR/GOT2/GSS/ENOPH1/MTAP/DNMT3A/CBS/APIP/PHGDH/DNMT3B	4.30549954294233
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	33/1477	110/9376	1.90440081245768	MAD2L1/CDK1/CCNB2/CCNA2/CCNB1/ANAPC15/CDC27/AURKA/ANAPC5/KIF22/PLK1/BUB1/CDC25A/PIK3R1/PKMYT1/KRAS/CDK2/PIK3R3/MAD1L1/CDC23/PDE3B/STK10/CDC25C/AKT1/RAF1/GNAI1/ARAF/AKT2/CDC25B/RPS6KA3/ADCY7/PIK3CB/ANAPC4	4.12573156136024
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	39/1477	138/9376	1.79400076535869	PTTG1/MAD2L1/SMC1A/CDK1/CCNB2/FBXO5/CCNB1/ANAPC15/SMC3/CALM3/CDC27/CCNE1/YWHAH/AURKA/ANAPC5/CDC20/YWHAQ/PLK1/YWHAB/YWHAE/PPP1CA/BUB1/PPP1CC/PPP2R1B/PKMYT1/PPP2R5E/CDK2/SLK/MAD1L1/CDC23/PPP3CA/CDC25C/CUL1/BTRC/RPS6KA3/ADCY7/ANAPC4/ESPL1/CCNE2	4.06313557999256
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	13/1477	28/9376	2.9472869716607	TECR/HADHA/PPT2/HADH/ELOVL1/ELOVL6/HSD17B12/ELOVL5/THEM4/ACOT7/MECR/ACAA2/MBLAC2	4.46210156114086
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	27/1477	85/9376	2.01642438966108	DUT/TYMS/RRM2/ADSL/TK1/DTYMK/NME4/APRT/NME1/NT5DC4/RRM1/HDDC2/GMPS/CTPS1/AK2/DCTPP1/IMPDH2/ADK/UCK2/NUDT16/NT5C3B/DCTD/NME1-NME2/UCK1/NME7/AK4/ENTPD5	4.07045670149139
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	10/1477	19/9376	3.34105405694331	GCSH/PDHA1/PDHB/DLD/OGDH/DLAT/DHTKD1/BCKDHB/DBT/GLDC	4.41682056993455
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	8/1477	13/9376	3.9064632050414	PRKDC/FEN1/XRCC5/XRCC6/RAD50/DCLRE1C/XRCC4/LIG4	4.53438949782983
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	41/1477	154/9376	1.69005266906418	UROS/DHFR/UROD/ALAS2/ADSL/FECH/CPOX/NME4/ALAD/HMBS/NME1/GGH/MTHFD1/CTPS1/AK2/DLD/UMPS/PTS/PPOX/MTHFD1L/UGP2/PANK2/MMAB/GSS/VKORC1/SHMT1/MTHFD2L/QPRT/SHMT2/NADK/GUSB/MOCS2/COQ3/VKORC1L1/COQ2/DHODH/GPHN/NME1-NME2/NME7/RDH13/AK4	3.73353193502368
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	21/1477	63/9376	2.11600090273076	EZH2/ACAT2/HADHA/HADH/DLD/GCDH/CAMKMT/EZH1/ALDH9A1/SUV39H2/SMYD2/PLOD1/ALDH7A1/KMT2A/EHMT1/NSD1/ACAT1/DHTKD1/COLGALT1/SUV39H1/PHYKPL	3.84308374300423
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	17/1477	47/9376	2.29608608594189	LDHB/LDHA/PKLR/ACAT2/ADH5/GRHPR/PDHA1/FH/PDHB/DLD/MDH2/ACYP1/MDH1/ALDH9A1/ALDH7A1/DLAT/ACAT1	3.85172311318233
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	13/1477	32/9376	2.57887610020311	LDHB/LDHA/PCCB/HADHA/ECHDC1/DLD/SUCLG1/ABAT/SUCLA2/BCKDHB/SUCLG2/DBT/HIBCH	3.8685343191642
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/1477	57/9376	2.11600090273076	ACAT2/TECR/HADHA/SCP2/PPT2/HADH/ELOVL1/ACADM/ELOVL6/HSD17B12/ELOVL5/CBR4/FASN/MECR/HSD17B4/ACAT1/FADS1/MCAT/ACAA2	3.65432481311989
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	23/1477	75/9376	1.9467208305123	GAPDH/PKLR/PGK1/ENO1/MTR/GOT2/PYCR2/RPIA/IDH2/PRPS1/CS/ALDH18A1/SHMT1/CBS/PRPS2/PFKL/ASL/SHMT2/PHGDH/IDH1/PFKP/PSPH/GPT2	3.55940635394088
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	13/1477	33/9376	2.5007283395909	PDHA1/PDHB/DLD/GOT2/IDH2/CS/OGDH/DLAT/DHTKD1/IDH1/BCKDHB/DBT/GPT2	3.73426993617112
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	22/1477	71/9376	1.96698675465113	LDHB/MYC/LDHA/HK1/PDHA1/PDHB/PIK3R1/KRAS/FGFR1/IDH2/SLC1A5/PIK3R3/PFKL/PDK1/SLC16A3/AKT1/RAF1/MTOR/IDH1/AKT2/PIK3CB/PFKP	3.53656251917765
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/1477	30/9376	2.53920108327691	DHFR/TYMS/GGH/ATIC/GART/MTR/ABCG2/SHMT1/SHMT2/ABCC4/FOLR1/SLC19A1	3.65117734743868
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	42/1477	170/9376	1.5683300808475	MYC/MGST3/SMARCC1/ACTL6A/BRD7/SMARCA4/DPF3/SMARCB1/GAB1/PIK3R1/ARID1A/PBRM1/KRAS/CTNNB1/MGST1/SMARCD1/APC/BCL2L1/PIK3R3/E2F3/E2F1/CDK6/GSTA4/KEAP1/LRP6/AKT1/RAF1/E2F2/TCF7L2/ARID1B/MTOR/ARAF/AKT2/GSK3B/FZD5/PIK3CB/ARID2/SMARCA2/WNT7A/FZD3/AXIN1/AXIN2	3.23354900806322
Genetic Information Processing	Transcription	hsa03040	Spliceosome	56/1477	243/9376	1.46291420435707	HNRNPA3/HSPA8/SNRPD1/SNRPF/LSM5/HNRNPA1/HNRNPM/SNRPB/RBM25/RBMX/ALYREF/LSM2/DDX46/SRSF2/LSM6/HNRNPU/SRSF9/TCERG1/SNRPA/SNRNP70/LSM4/SNRPB2/RBM17/DDX5/PPIH/PRPF40A/CDC5L/U2AF1/SRSF6/SRSF4/SRSF10/MAGOHB/THOC2/PPIL1/ACIN1/SRSF1/SNRNP40/U2SURP/PLRG1/SF1/DHX15/PRPF38A/CCDC12/THOC1/RBMX2/DDX42/THOC6/SF3B3/EFTUD2/THOC5/NCBP1/USP39/DHX16/AQR/DDX39B/HNRNPA1L2	3.16145310448888
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	24/1477	83/9376	1.83556704815199	SUZ12/CBX3/TFDP1/PHF19/HDAC2/RBBP7/EZH2/AURKB/HDAC1/MTF2/RBBP4/USP16/HCFC1/CBX6/EZH1/LCOR/WDR5/JARID2/BAP1/L3MBTL2/SCML2/SFMBT1/BCOR/PCGF3	3.30622352056832
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/1477	44/9376	2.16409183233828	RPN2/DDOST/OSTC/MAN2A1/STT3B/MAGT1/RPN1/MAN1A2/TUSC3/STT3A/B4GALT1/FUT8/ALG14/ALG9/ALG1	3.34669430139378
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	42/1477	174/9376	1.53227651577055	HSPA8/PDIA6/RPN2/LMAN1/PDIA3/ERP29/UBXN4/HSP90B1/CALR/RAD23B/VCP/DDOST/PDIA4/OSTC/P4HB/PRKCSH/SSR1/STT3B/BAG2/BCAP29/MAGT1/RPN1/GANAB/MAN1A2/ERLEC1/TUSC3/DNAJC1/RRBP1/STT3A/ATF6/DNAJC10/PLAA/UGGT1/CUL1/HSPA4L/CKAP4/EDEM2/TRAF2/SIL1/UGGT2/ATF6B/MBTPS2	3.06450718541018
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	20/1477	67/9376	1.89492618154993	LDHB/GAPDH/LDHA/PKLR/PGK1/HK1/ENO1/ADH5/PDHA1/PDHB/DLD/ALDH9A1/PFKL/GPI/ALDH7A1/DLAT/PGM2/PGM1/MINPP1/PFKP	3.17879798410785
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	24/1477	87/9376	1.75117316088063	BIRC5/MYC/MSH2/MSH6/PIK3R1/APPL1/MLH1/KRAS/CTNNB1/MSH3/APC/PIK3R3/RAC3/AKT1/RAF1/TCF7L2/MTOR/ARAF/AKT2/GSK3B/RALB/PIK3CB/AXIN1/AXIN2	3.04372236997961
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	47/1477	203/9376	1.46973461716767	TLN1/CCND3/ITGB1/PPP1R12A/ACTN4/PGF/RELN/PPP1CA/PAK2/COL4A1/PPP1CC/ROCK1/COL1A1/ITGA4/PIK3R1/COL4A2/CAV1/FYN/CTNNB1/LAMA4/COL1A2/ROCK2/PIK3R3/FLNB/ITGA5/COL6A2/RAC3/COL6A1/AKT1/RAF1/LAMB1/PARVA/PAK4/PXN/AKT2/GSK3B/CAV2/LAMC1/ARHGAP35/PIP5K1A/PIK3CB/FLT4/PPP1R12B/COL4A5/COL6A3/ITGA1/DOCK1	2.92573318641357
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	25/1477	93/9376	1.7064523409119	MYC/CKS1B/CCNE1/ITGB1/COL4A1/PIK3R1/COL4A2/SKP2/LAMA4/CDK2/BCL2L1/PIK3R3/E2F3/E2F1/CDK6/AKT1/E2F2/LAMB1/AKT2/TRAF2/LAMC1/PIK3CB/CCNE2/COL4A5/TRAF4	2.96053361471766
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/1477	128/9376	1.58700067704807	RRM2/ADSL/NME4/PAICS/APRT/NME1/NT5DC4/RRM1/HDDC2/GMPS/PPAT/ATIC/NUDT5/AK2/GART/IMPDH2/PRPS1/NUDT2/ADK/PRPS2/PDE3B/NUDT16/PGM2/PGM1/PFAS/NUDT9/ADCY7/NME1-NME2/NME7/PDE7A/AK4/ENTPD5	2.89140884614622
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	77/1477	368/9376	1.3282505666598	TUBA1B/TUBB/HNRNPA3/COX6C/NDUFA4/HNRNPA2B1/TUBB6/HNRNPA1/PSMD1/TUBA1C/ALYREF/DCTN3/MT-CO3/PSMD14/PSMA4/VDAC1/NDUFS5/PSMD2/CAT/NDUFC2/NUP37/MT-CO1/TPR/COX5A/VCP/PSMA1/PSMC1/PSMC2/UQCRFS1/TOMM40/NUP107/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NUP50/NDUFS7/NDUFB11/PSMD6/NDUFA10/MT-CO2/PSMD11/UQCRH/NUP54/NDUFS2/NUP62/NDUFS1/SEH1L/NUP93/MT-ND6/GPX8/BCL2L1/NUP155/NUP88/CHMP2B/NUP160/SDHC/ATF6/NUP43/PPP3CA/NUP210/NUP205/NCBP1/NDC1/WDR41/NUP85/MTOR/NUP35/TRAF2/NUP188/NUP153/DNAH14/HNRNPA1L2/HDAC6/NUP133/PIK3R4/NEFH	2.77782597116908
NA	NA	hsa04981	Folate transport and metabolism	11/1477	31/9376	2.25251709000371	DHFR/TYMS/MTHFD1/MTR/ABCG2/SHMT1/MTHFS/SHMT2/ABCC4/FOLR1/SLC19A1	3.02040154206782
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1477	44/9376	2.01981904351573	TBPL1/TAF15/MNAT1/GTF2I/GTF2H5/GTF2F2/CDK7/TAF8/TAF2/TAF5L/CCNH/GTF2H2/ERCC3/TAF5	2.93191867391707
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/1477	36/9376	2.11600090273076	ST6GALNAC1/GALNT14/C1GALT1/GALNT1/GALNT2/GALNT10/ST6GALNAC4/ST3GAL2/GALNT5/B4GALT5/C1GALT1C1/ST6GALNAC2	2.9008961864901
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/1477	59/9376	1.8290855260893	MYC/PIK3R1/MLH1/KRAS/CTNNB1/APC/PIK3R3/AKT1/RAF1/TCF7L2/ARAF/AKT2/GSK3B/PIK3CB/CDH1/AXIN1/AXIN2	2.76233992493973
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	13/1477	41/9376	2.01278134649999	ALAS2/GCSH/GRHPR/DLD/GCAT/SHMT1/GAMT/CBS/SHMT2/ALDH7A1/PHGDH/PSPH/GLDC	2.81021980428635
NA	NA	hsa04518	Integrin signaling	36/1477	154/9376	1.48394868503196	TLN1/CCND3/ITGB1/ACTN4/PGF/RELN/COL4A1/COL1A1/ITGA4/PIK3R1/COL4A2/FERMT2/ITGAE/CTNNB1/LAMA4/COL1A2/PIK3R3/FLNB/ITGA5/COL6A2/RAC3/COL6A1/AKT1/LAMB1/PARVA/MTOR/PXN/AKT2/GSK3B/LAMC1/PIK3CB/CDH1/FLT4/COL4A5/COL6A3/ITGA1	2.61840574130364
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	26/1477	103/9376	1.60240845061164	ALYREF/PNN/PABPC1/PABPC4/RNPS1/PPP1CA/MAGOHB/ACIN1/PPP1CC/PPP2R1B/DAZAP1/CPSF3/CPSF6/PPP2R5E/CPSF2/CPSF1/PPP2R3B/NCBP1/SMG6/CSTF2/CPSF7/RNGTT/UPF1/CSTF2T/DDX39B/SMG7	2.65821048650625
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/1477	205/9376	1.39346400911538	GAPDH/CD36/COX6C/NDUFA4/MMP2/VDAC3/MT-CO3/PARP1/VDAC1/NDUFS5/NDUFC2/MT-CO1/PDHA1/COX5A/PDHB/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/PPP1CA/NDUFA9/NDUFS7/NDUFB11/NDUFA10/SLC25A5/MT-CO2/UQCRH/PPP1CC/COL1A1/NDUFS2/PIK3R1/COL3A1/NDUFS1/MT-ND6/COL1A2/PIK3R3/SDHC/AKT1/MTOR/AKT2/GSK3B/TBC1D4/PIK3CB/PRKCZ/PDK2	2.46299440641778
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1477	30/9376	2.11600090273076	GPAA1/PIGK/PIGS/PIGX/PIGF/PIGQ/PGAP2/PIGT/PIGU/PIGW	2.64729362527261
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	20/1477	77/9376	1.64883187225774	MYC/HDAC2/HDAC1/CTBP2/PTPN11/STAT5B/PIK3R1/KRAS/BCL2L1/PIK3R3/E2F3/CTBP1/E2F1/CDK6/AKT1/RAF1/E2F2/ARAF/AKT2/PIK3CB	2.47200442053921
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1477	14/9376	2.72057258922526	CHST2/B4GALT4/ST3GAL2/B4GALT1/B3GNT2/FUT8	2.78575249512485
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/1477	18/9376	2.46866771985255	MMADHC/CD320/MTR/MMAB/HCFC1/ZNF76/LMBRD1	2.69685819141037
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1477	73/9376	1.65221988295416	PPIA/PSIP1/MLLT3/RAN/MAP1B/MAP1A/XPO1/SMARCB1/CPSF6/ELL2/APOBEC3B/FURIN/KAT2B/CPSF7/NELFB/CHMP6/NUP153/TNPO3/APOBEC3F	2.41898838290168
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/1477	27/9376	2.11600090273076	TECR/SCP2/ELOVL1/ELOVL6/HSD17B12/ELOVL5/ACOT7/HSD17B4/FADS1	2.51104026657113
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/1477	23/9376	2.20800094197992	ACAT2/FDPS/ZMPSTE24/ICMT/HMGCS1/PDSS1/NUS1/ACAT1	2.5081040688012
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	19/1477	75/9376	1.60816068607538	TOP2A/BIRC5/MGST3/MSH2/MSH6/BRCA1/PIK3R1/MLH1/MGST1/MSH3/BCL2L1/PIK3R3/GSTA4/AKT1/TOP2B/AKT2/PIK3CB/ATM/FADD	2.28651460965781
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	10/1477	32/9376	1.98375084631009	HK1/UGP2/AKR1B1/PFKL/B4GALT1/PGM2/GALE/GLB1/PGM1/PFKP	2.41036893899896
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	13/1477	46/9376	1.79400076535869	UROS/UROD/ALAS2/FECH/CPOX/ALAD/BLVRB/HMBS/FXN/PPOX/MMAB/HCCS/GUSB	2.3342579358498
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	28/1477	122/9376	1.45691865433921	MYC/HDAC2/ATP1B2/HDAC1/PLCD1/PIK3R1/DIO2/NCOA1/NCOR1/MED30/KRAS/ATP1A1/CTNNB1/PIK3R3/PFKL/MED24/KAT2B/AKT1/RAF1/MED1/MTOR/AKT2/GSK3B/RCAN1/TBC1D4/PIK3CB/MED14/PFKP	2.19656412251001
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	43/1477	205/9376	1.33153227537692	HLA-G/RANBP1/CDK1/CCNA2/CCND3/VDAC3/HDAC2/CHEK1/CCNE1/YWHAH/TBPL1/CDC20/YWHAQ/ACTN4/HDAC1/YWHAB/CHD4/PSMC1/YWHAE/DDB1/RBL1/STAT5B/PIK3R1/SKP2/KRAS/UBE3A/SND1/CDK2/PIK3R3/MAD1L1/EIF2AK2/CREB1/DLG1/KAT2B/CDK6/GTF2H2/PXN/TRAF2/ATF6B/PIK3CB/HDAC6/HDAC8/CCNE2	2.0753159650769
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1477	77/9376	1.56639027864485	RALBP1/BRCA2/PIK3R1/RAD51/KRAS/BCL2L1/PIK3R3/E2F3/E2F1/RAC3/CDK6/AKT1/RAF1/E2F2/MTOR/ARAF/AKT2/RALB/PIK3CB	2.15790766826623
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	20/1477	83/9376	1.52963920679332	GSTK1/PXMP2/CAT/SCP2/ECI2/MPV17/IDH2/PEX2/ABCD3/SLC27A2/AGPS/HSD17B4/GNPAT/FAR1/IDH1/NUDT12/NUDT7/PEX13/NUDT19/PEX7	2.09570926329386
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	19/1477	78/9376	1.54630835199556	DNM2/ITGB1/ARPC1A/CLTC/GAB1/PIK3R1/CD2AP/CAV1/CTTN/CTNNB1/PIK3R3/ITGA5/WASF1/PXN/CAV2/PIK3CB/CDH1/ARHGAP10/DOCK1	2.0949815348475
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1477	34/9376	1.86705962005655	POLR3K/POLR2H/POLR3H/POLR1E/POLR3B/POLR3A/POLR3E/POLR1A/POLR1B/POLR2M	2.1900716183541
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	21/1477	89/9376	1.49784333564088	CD36/HMMR/ITGB1/RELN/COL4A1/COL1A1/ITGA4/COL4A2/CD47/LAMA4/COL1A2/ITGA5/COL6A2/COL6A1/DAG1/LAMB1/SDC4/LAMC1/COL4A5/COL6A3/ITGA1	2.04051507363776
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	44/1477	214/9376	1.30519681850682	HLA-G/CDK1/CCNB2/CCNB1/CALM3/CHEK1/PDIA3/CALR/GNG2/PAK2/DDB1/PIK3R1/KRAS/APOBEC3B/BCL2L1/PIK3R3/AP1B1/PPP3CA/RAC3/AP1M1/CDC25C/CUL1/AKT1/RAF1/NFATC2/GNAI1/PAK4/BTRC/GNG12/MAP3K7/MTOR/GNG3/PXN/AKT2/TRAF2/PIK3CB/AP1S1/ATM/AP1G2/FADD/APOBEC3F/IRAK4/GNG4/TAB1	1.95290705323924
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	65/1477	333/9376	1.23909962772522	HLA-G/CCNA2/CCND3/HDAC2/TUBG1/CCNE1/ITGB1/TBPL1/HDAC1/CHD4/PSMC1/RELN/RBL1/ATP6V0A2/COL4A1/ATP6V1A/PPP2R1B/COL1A1/ITGA4/PIK3R1/COL4A2/PPP2R5E/KRAS/ATP6V0A1/UBE3A/CTNNB1/LAMA4/COL1A2/CDK2/APC/PIK3R3/EIF2AK2/E2F1/CREB1/ITGA5/DLG1/COL6A2/PPP2R3B/CDK6/COL6A1/ATP6V1H/AKT1/RAF1/LAMB1/TCF7L2/MTOR/PXN/AKT2/GSK3B/FZD5/LAMC1/PIK3CB/ATP6V1C2/ATM/ATP6V0E2/WNT7A/CCNE2/COL4A5/COL6A3/FADD/FZD3/AXIN1/PRKCZ/ITGA1/AXIN2	1.92103191563171
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1477	59/9376	1.61389899360821	RRM2/MGST3/SRM/GGCT/RRM1/GSTK1/SMS/CHAC2/GSS/IDH2/MGST1/GPX8/GSTA4/IDH1/LANCL1	2.0453833127725
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/1477	138/9376	1.38000058873745	COX6C/PPA1/NDUFA4/MT-CO3/NDUFS5/NDUFC2/MT-CO1/COX5A/PPA2/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/NDUFB11/ATP6V0A2/NDUFA10/ATP6V1A/MT-CO2/UQCRH/NDUFS2/NDUFS1/ATP6V0A1/MT-ND6/COX11/SDHC/ATP6V1H/ATP6V1C2/ATP6V0E2	1.94457484158692
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1477	75/9376	1.52352064996615	RRM2/CDK1/CCNB2/CCNB1/CCND3/CHEK1/GTSE1/CCNE1/PERP/STEAP3/MDM4/CDK2/BCL2L1/SHISA5/CHEK2/CDK6/ATM/CCNE2	1.96829167358704
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	53/1477	268/9376	1.25538859527683	TUBA1B/TUBB/SNCA/COX6C/NDUFA4/TUBB6/VDAC3/PSMD1/CALM3/TUBA1C/TXN2/MT-CO3/PSMD14/PSMA4/VDAC1/NDUFS5/PSMD2/NDUFC2/HTRA2/MT-CO1/COX5A/PSMA1/TRAP1/PSMC1/PSMC2/PARK7/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/SLC39A3/NDUFB11/PSMD6/NDUFA10/SLC25A5/MT-CO2/PSMD11/UQCRH/NDUFS2/MFN1/NDUFS1/MT-ND6/SLC11A2/UBA1/BCL2L1/SDHC/SLC39A4/ATF6/KEAP1/SLC39A10/GNAI1	1.83420221825426
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/1477	27/9376	1.88088969131623	ACAT2/HADHA/HADH/ABAT/HMGCS1/ACAT1/OXCT1/BDH1	1.98203198571795
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	73/1477	388/9376	1.19434071571659	TUBA1B/TUBB/SNCA/GAPDH/COX6C/NDUFA4/TUBB6/VDAC3/PSMD1/CALM3/HSD17B10/TUBA1C/MT-CO3/PSMD14/PSMA4/VDAC1/NDUFS5/PSMD2/NDUFC2/MT-CO1/COX5A/PSMA1/PSMC1/PSMC2/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/SLC39A3/NDUFB11/PSMD6/NDUFA10/SLC25A5/MT-CO2/PSMD11/UQCRH/NDUFS2/PIK3R1/NAE1/NDUFS1/KRAS/CTNNB1/MT-ND6/PPID/SLC11A2/APC/PIK3R3/EIF2AK2/SDHC/SLC39A4/ATF6/PPP3CA/LRP6/SLC39A10/IDE/BACE2/AKT1/RAF1/MTOR/ARAF/AKT2/TRAF2/GSK3B/FZD5/PIK3CB/PIK3R4/WNT7A/FADD/FZD3/AXIN1/AXIN2	1.69058868396935
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1477	37/9376	1.71567640761954	CMAS/HK1/UGP2/GPI/PGM2/GALE/PGM1/GNPNAT1/UXS1/GMDS	1.88606738103194
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1477	10/9376	2.53920108327691	SELENBP1/MPST/BPNT1/SUOX	2.10575631880923
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1477	68/9376	1.49364769604524	MYC/CCNA2/PIM1/STAT5B/PIM2/PIK3R1/KRAS/RUNX1T1/PIK3R3/AKT1/RAF1/TCF7L2/MTOR/ARAF/AKT2/PIK3CB	1.76657960566152
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1477	28/9376	1.81371505948351	DHFR/GGH/PTS/QDPR/PCBD2/AKR1B1/MOCS2/GPHN	1.86458354114529
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	23/1477	106/9376	1.37739681404172	CCNE1/HSP90B1/PIK3R1/KRAS/CTNNB1/FGFR1/CDK2/PIK3R3/E2F3/E2F1/CREB1/AKT1/RAF1/E2F2/TCF7L2/MTOR/ARAF/AKT2/GSK3B/FOLR1/PIK3CB/CCNE2/SLC19A1	1.68966700732481
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/1477	43/9376	1.62390766953756	ACAT2/ADH5/HADHA/HADH/ACADM/GCDH/ECI2/ALDH9A1/ALDH7A1/ACAT1/ACAA2	1.77310211626797
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	32/1477	156/9376	1.30215440168047	MYC/YWHAH/YWHAQ/YWHAB/EIF3E/YWHAE/PPP2R1B/PIK3R1/CLDN7/KRAS/CTNNB1/PSME3/CDK2/PIK3R3/E2F3/EIF2AK2/E2F1/CDK6/LDLR/CLDN4/AKT1/RAF1/E2F2/ARAF/AKT2/TRAF2/GSK3B/PIK3CB/CLDN10/CLDN19/CLDN6/FADD	1.64556708862555
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	32/1477	157/9376	1.2938604245997	COX6C/PKLR/NDUFA4/MT-CO3/NDUFS5/NDUFC2/MT-CO1/COX5A/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/NDUFB11/NDUFA10/MT-CO2/UQCRH/NDUFS2/PIK3R1/LEP/NDUFS1/PIK3R3/PPARG/SDHC/MLX/AKT1/LEPR/AKT2/TRAF2/GSK3B/PIK3CB	1.60560550841682
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1477	15/9376	2.11600090273076	ST8SIA1/ST6GALNAC4/ST3GAL2/GLB1/SLC33A1	1.8704188978496
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1477	49/9376	1.55461290812872	GALNT14/C1GALT1/GALNT1/GALNT2/GALNT10/GALNT5/B4GALT1/POGLUT1/C1GALT1C1/COLGALT1/XXYLT1/POFUT1	1.68308811691413
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/1477	204/9376	1.24470641337104	MYC/MMP2/ITGB1/PPP1R12A/DDX5/ANK1/PPP1CA/RDX/PPP1CC/PTPN11/ROCK1/GAB1/COL1A1/PIK3R1/CAV1/KRAS/CTTN/CTNNB1/FGFR1/COL1A2/ROCK2/ARHGEF12/PIK3R3/EZR/ITGA5/AKT1/RAF1/MTOR/SDC4/ARAF/PXN/AKT2/CAV2/FZD5/DROSHA/PIK3CB/PPP1R12B/WNT7A/FZD3/GPC1	1.527982011011
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	48/1477	250/9376	1.21881651997292	CTSE/SLC29A1/AP2A1/AP2M1/VPS29/CLTC/LAPTM4B/PPT2/ATP6V0A2/FUCA2/ATP6V1A/BLOC1S6/ATP6V0A1/CLN6/VPS13A/SLC11A2/MLST8/AP3D1/AP3B1/AP1B1/GUSB/VPS13C/BLOC1S5/ATP6V1H/VPS16/AP1M1/TELO2/GGA2/GLB1/CLN5/VPS41/AP3M1/MTOR/STX17/TTI1/AP4E1/IGF2R/ATP6V1C2/DMXL1/AP1S1/SORT1/MFSD8/ATP6V0E2/AP1G2/NCOA7/AP3M2/TMEM175/CTSV	1.5163508807542
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/1477	20/9376	1.90440081245768	LBR/SQLE/EBP/MSMO1/DHCR24/DHCR7	1.75073600759694
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	45/1477	235/9376	1.21557498667512	COX6C/NDUFA4/COA1/MT-CO3/NDUFS5/COX16/NDUFC2/MT-CO1/SMARCC1/COX5A/ACTL6A/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/SMARCA4/DPF3/NDUFB11/NDUFA10/MT-CO2/UQCRH/SMARCB1/NDUFS2/ARID1A/NDUFS1/KRAS/KDM1A/FGFR1/MT-ND6/SMARCD1/COX11/MLST8/PPARG/CREB1/SDHC/NDUFAF5/ARID1B/MTOR/RPS6KA3/ADCY7/KDM3B/COX18/SMARCA2	1.44718906904209
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/1477	144/9376	1.2784172120665	MYC/ID1/RIF1/ID3/PIK3R1/KRAS/CTNNB1/LIFR/FGFR1/TCF3/APC/PIK3R3/SMARCAD1/JARID2/JAK2/AKT1/RAF1/AKT2/GSK3B/FZD5/DUSP9/PIK3CB/DLX5/ID4/WNT7A/PCGF3/FZD3/AXIN1/AXIN2	1.45585880507448
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/1477	46/9376	1.5180006476112	PSMD1/PSMD14/PSMA4/PSMD2/PSMA1/PSMC1/PSMC2/PSMD6/PSMD11/PSME3/PSME4	1.52285385004074
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1477	31/9376	1.63819424727543	RPIA/PRPS1/PRPS2/PFKL/GPI/PGM2/PGM1/PFKP	1.53898330329673
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1477	12/9376	2.11600090273076	VKORC1/COQ3/VKORC1L1/COQ2	1.67268551232778
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/1477	42/9376	1.51142921623626	ACAT2/CAT/HADHA/HADH/DLD/GCDH/ALDH9A1/ALDH7A1/ACAT1/DHTKD1	1.43636928617996
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1477	37/9376	1.54410876685758	ADSL/PPAT/ASRGL1/NIT2/GOT2/ABAT/ASL/RIMKLB/GPT2	1.43392430709992
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1477	37/9376	1.54410876685758	MYC/TPR/KRAS/CTNNB1/TFG/PPARG/CCDC6/TCF7L2/CDH1	1.43392430709992
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	29/1477	148/9376	1.24386539552416	MYC/BRCA2/BRCA1/PIK3R1/NCOA1/KRAS/CTNNB1/FGFR1/APC/PIK3R3/E2F3/E2F1/CDK6/LRP6/AKT1/RAF1/E2F2/TCF7L2/MTOR/ARAF/AKT2/GSK3B/FZD5/PIK3CB/FLT4/WNT7A/FZD3/AXIN1/AXIN2	1.29305522062211
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1477	70/9376	1.36028629461263	FH/PAK2/PTPN11/GAB1/PIK3R1/KRAS/CUL2/PIK3R3/EGLN3/AKT1/RAF1/PAK4/ARAF/AKT2/PIK3CB	1.3082931472962
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/1477	155/9376	1.22864568545657	ASH2L/CCNE1/FH/CDKN2C/CTNNB1/CDK2/USP8/APC/CYP11A1/E2F3/WDR5/E2F1/CREB1/HSD3B1/CDK6/LDLR/KMT2A/E2F2/TCF7L2/GNAI1/GSK3B/STAR/FZD5/ATF6B/ADCY7/WNT7A/CCNE2/FZD3/AXIN1/AXIN2	1.24116544982152
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1477	104/9376	1.28180823915421	AGPAT5/LYPLA1/PISD/SGMS1/AGPAT1/MBOAT2/AGPAT4/PLA2G2A/PTDSS1/AGPAT3/LPCAT3/PTDSS2/PNPLA6/LYPLA2/PEMT/GNPAT/CDS2/PLA2G10/LCLAT1/PGS1/GPAM	1.24960706926988
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	56/1477	308/9376	1.15418231058041	TUBA1B/TUBB/COX6C/NDUFA4/TUBB6/VDAC3/PSMD1/HDAC2/TUBA1C/DCTN3/MT-CO3/AP2A1/PSMD14/PSMA4/VDAC1/NDUFS5/PSMD2/TBPL1/AP2M1/NDUFC2/CLTC/MT-CO1/HDAC1/POLR2H/COX5A/PSMA1/TGM2/PSMC1/PSMC2/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/TFAM/NDUFB11/PSMD6/NDUFA10/SLC25A5/MT-CO2/PSMD11/UQCRH/NDUFS2/NDUFS1/MT-ND6/GPX8/RCOR1/PPARG/CREB1/SDHC/MTOR/IFT57/TRAF2/DNAH14/PIK3R4	1.1897178598685
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1477	93/9376	1.29690377909305	ACTN4/PDCD10/ROCK1/KRIT1/FYN/CTNNB1/FGFR1/CTNND1/CCM2/ROCK2/RAC3/HEG1/TCF7L2/MAP3K7/ARHGAP29/WASF1/CDH1/NLK/SNAI1	1.24423625974124
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	29/1477	150/9376	1.22728052358384	MYC/CCNE1/GAB1/PIK3R1/MLH1/KRAS/CTNNB1/CDK2/APC/PIK3R3/E2F3/E2F1/LRP6/AKT1/RAF1/E2F2/TCF7L2/MTOR/ARAF/AKT2/GSK3B/FZD5/PIK3CB/CDH1/WNT7A/CCNE2/FZD3/AXIN1/AXIN2	1.2133635783099
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	22/1477	110/9376	1.26960054163846	MYC/TFDP1/TF/TFRC/HDAC2/ID1/HDAC1/RBL1/LTBP1/TFR2/ID3/ROCK1/PPP2R1B/E2F4/NCOR1/SMAD6/CUL1/LRRC32/E2F5/LEMD3/ID4/TMEM53	1.22987446304361
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/1477	82/9376	1.3160493419423	DUT/RRM2/MGST3/TK1/NME4/NME1/RRM1/GMPS/UMPS/IMPDH2/MGST1/UCK2/GUSB/GSTA4/NME1-NME2/UCK1/NME7	1.24294042031896
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1477	28/9376	1.58700067704807	CA2/SLC4A1/ATP6V0A2/ATP6V1A/ATP6V0A1/ATP6V1C2/ATP6V0E2	1.34507993714617
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/1477	116/9376	1.25865570938295	MMP2/ITGB1/ACTN4/PTPN11/ROCK1/ITGA4/PIK3R1/CLDN7/CTNNB1/CTNND1/ROCK2/PIK3R3/EZR/CLDN4/GNAI1/JAM3/PXN/ARHGAP35/PIK3CB/CLDN10/CLDN19/CLDN6/SIPA1	1.21209148241456
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	30/1477	157/9376	1.21299414806222	BIRC5/MYC/CCND3/ID1/YWHAH/YWHAQ/YWHAB/YWHAE/PPP1CA/TP53BP2/PPP1CC/PPP2R1B/MOB1B/SAV1/CTNNB1/APC/DLG1/NF2/TCF7L2/BTRC/WWTR1/GSK3B/FZD5/CDH1/WNT7A/YAP1/FZD3/AXIN1/PRKCZ/AXIN2	1.16376534150558
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	31/1477	163/9376	1.20728885861326	BIRC5/MYC/CCNA2/PCNA/VDAC3/CCNE1/YWHAQ/YWHAB/DDB1/STAT5B/PIK3R1/KRAS/CDK2/PIK3R3/E2F3/E2F1/CREB1/JAK2/AKT1/RAF1/E2F2/NFATC2/MAP3K7/ARAF/AKT2/ATF6B/PIK3CB/CCNE2/FADD/IRAK4/TAB1	1.1544072770797
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/1477	275/9376	1.15418231058041	TUBA1B/TUBB/HSPA8/COX6C/NDUFA4/TUBB6/VDAC3/PSMD1/TUBA1C/EGR1/MT-CO3/PSMD14/PSMA4/VDAC1/NDUFS5/PSMD2/NDUFC2/MT-CO1/COX5A/PSMA1/PSMC1/PSMC2/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/NDUFB11/PSMD6/NDUFA10/SLC25A5/MT-CO2/PSMD11/UQCRH/NDUFS2/PIK3R1/CAV1/FYN/NDUFS1/MT-ND6/PIK3R3/CREB1/SDHC/PPP3CA/GSK3B/CAV2/LAMC1/ATF6B/PIK3CB	1.12213773870674
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1477	50/9376	1.3965605958023	SRM/SMS/GOT2/PYCR2/ALDH18A1/ALDH9A1/GAMT/ALDH7A1/CNDP2/P4HA1/L3HYPDH	1.21572874095726
Cellular Processes	Cell motility	hsa04814	Motor proteins	36/1477	194/9376	1.17797988399444	MYL4/TUBA1B/TUBB/TUBB6/KIF20B/TUBA1C/DCTN3/TUBG1/CENPE/MYH10/TPM1/KIF11/KIF22/KIF4A/KIF23/KIFC1/KIF2C/KIF15/TPM2/KIF18A/KIF14/TPM4/DYNC1I2/KIF20A/KIF18B/KIFAP3/MYO19/TUBD1/KIF21A/MYO18B/TNNI2/MYO18A/MYO1B/DNAH14/MYO10/KIF3B	1.08316088658223
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1477	62/9376	1.33103282591128	HSPA8/HDAC2/CAT/HDAC1/PIK3R1/KRAS/PIK3R3/CLPB/AKT1/MTOR/AKT2/ADCY7/PIK3CB	1.13080733883892
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	42/1477	232/9376	1.14920738682791	IQGAP2/DIAPH3/MYH10/ITGB1/PPP1R12A/ARPC1A/ACTN4/PPP1CA/RDX/PAK2/PPP1CC/ROCK1/ITGA4/PIK3R1/ITGAE/KRAS/FGFR1/ROCK2/ARHGEF12/SSH2/APC/PIK3R3/EZR/ITGA5/ABI2/RAC3/ENAH/AKT1/RAF1/PAK4/NCKAP1/GNG12/WASF1/ARAF/PXN/AKT2/ARHGAP35/PIP5K1A/PIK3CB/PPP1R12B/ITGA1/DOCK1	0.995075508096234
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1477	41/9376	1.39346400911538	MYC/MMP2/KRAS/E2F3/E2F1/RAF1/E2F2/ARAF/CDH1	1.09176610974435
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1477	110/9376	1.21189142610944	LDHB/GAPDH/LDHA/TF/TFRC/PGK1/HK1/ENO1/PDHA1/PDHB/PIK3R1/CUL2/PIK3R3/PFKL/EGLN3/PDK1/AKT1/MTOR/AKT2/PIK3CB/PFKP	0.966614726833003
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	32/1477	178/9376	1.1412139700121	MYC/CCND3/RUVBL1/DAAM1/CTBP2/SERPINF1/LGR4/CTNNB1/NOTUM/ROCK2/APC/CTBP1/SENP2/PPP3CA/RAC3/LRP6/CUL1/NFATC2/TCF7L2/BTRC/GPC4/MAP3K7/GSK3B/FZD5/RYK/VANGL1/WNT7A/FZD3/AXIN1/CCAR2/NLK/AXIN2	0.822490310174057
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1477	101/9376	1.1941787272837	MMP2/EGR1/PLCD1/PIM1/COL4A1/STAT5B/COL1A1/PIK3R1/COL4A2/COL3A1/KRAS/COL1A2/PIK3R3/JAK2/AKT1/AKT2/PIK3CB/COL4A5/PRKCZ	0.848389347729203
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1477	38/9376	1.33642162277732	HK1/UGP2/GPI/PGM2/GALE/PGM1/GNPNAT1/UXS1	0.89854243849935
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	41/1477	233/9376	1.11703051946731	MYL4/LBR/TLN1/DAAM1/LMNB1/ATP1B2/DIAPH3/ENO1/MYH10/ITGB1/TPM1/LMNB2/COL4A1/DSP/TPM2/DSC2/COL1A1/ITGA4/COL4A2/COL3A1/TPM4/ATP1A1/TMOD3/COL1A2/FHL2/DSG2/ITGA5/COL6A2/COL6A1/DAG1/TNNI2/COL27A1/SDC4/NID1/CSRP1/PKP2/COL4A5/COL6A3/COL5A2/ITGA1/PDLIM2	0.782208556463955
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1477	73/9376	1.21742517691359	PIK3R1/KRAS/FGFR1/PIK3R3/E2F3/E2F1/CDK6/AKT1/RAF1/E2F2/ARAF/AKT2/PIK3CB/CDH1	0.806398257474285
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1477	73/9376	1.21742517691359	STAT5B/PIK3R1/KRAS/PIK3R3/E2F3/E2F1/CDK6/AKT1/RAF1/E2F2/ARAF/AKT2/EML4/PIK3CB	0.806398257474285
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1477	138/9376	1.15000049061454	PKLR/PRKAR2B/CALM3/HK1/FLOT2/PPP1CA/PRKAR2A/PPP1CC/PIK3R1/KRAS/PHKB/PIK3R3/CBLB/PDE3B/PYGL/FASN/AKT1/RAF1/MTOR/ARAF/AKT2/GSK3B/PIK3CB/PHKG2/PRKCZ	0.767596653583785
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	26/1477	144/9376	1.14616715564583	VDAC3/PSMD1/ATXN10/PSMD14/PSMA4/VDAC1/PSMD2/TBPL1/PSMA1/PSMC1/PSMC2/RELN/PSMD6/SLC25A5/PSMD11/PIK3R1/OPA1/AFG3L2/PIK3R3/AKT1/MTOR/AKT2/TRAF2/OMA1/PIK3CB/PIK3R4	0.764316038438184
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	32/1477	180/9376	1.12853381478974	HLA-G/SRPK1/ALYREF/SRSF2/PDIA3/SRSF9/CALR/SRSF6/SRSF4/PPP1CA/ZC3HAV1/SRSF1/PPP1CC/PTPN11/PIK3R1/EIF2B3/HCFC1/BCL2L1/PIK3R3/EIF2AK2/ITGA5/JAK2/AKT1/POU2F1/MAP3K7/MTOR/AKT2/TRAF2/PIK3CB/FADD/IRAK4/TAB1	0.752911615892795
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1477	86/9376	1.18102375966368	MYC/PAK2/STAT5B/GAB1/PIK3R1/KRAS/PIK3R3/CBLB/AKT1/RAF1/PAK4/MTOR/ARAF/AKT2/GSK3B/PIK3CB	0.729233779901949
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	22/1477	122/9376	1.14472179983795	CD36/CCNA2/STRADB/PPP2R1B/PIK3R1/LEP/PPP2R5E/PIK3R3/PPARG/CREB1/PFKL/PPP2R3B/FASN/AKT1/LEPR/MAP3K7/MTOR/AKT2/PIK3CB/PFKFB4/PFKP/EEF2K	0.69572715022732
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1477	23/9376	1.38000058873745	CA2/ATP1B2/MDH1/ATP1A1/AQP1	0.78897374135913
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	39/1477	227/9376	1.09062601594493	MGST3/COX6C/NDUFA4/VDAC3/MT-CO3/VDAC1/NDUFS5/CAT/NDUFC2/MT-CO1/COX5A/UQCRFS1/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/NDUFB11/NDUFA10/SLC25A5/MT-CO2/UQCRH/PTPN11/NDUFS2/PIK3R1/NDUFS1/KRAS/MT-ND6/MGST1/PIK3R3/SDHC/GSTA4/KEAP1/AKT1/PRKD3/RAF1/ARAF/AKT2/PIK3CB	0.5976801493453
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/1477	130/9376	1.1231081714494	MMP2/GNG2/COL4A1/COL1A1/PIK3R1/COL4A2/COL3A1/KRAS/COL1A2/PIK3R3/CREB1/AKT1/RAF1/GNAI1/GNG12/GNG3/AKT2/ATF6B/ADCY7/PIK3CB/COL4A5/PRKCZ/GNG4	0.611183246792376
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/1477	76/9376	1.16936891993016	CALM3/PIK3R1/KRAS/PIK3R3/E2F3/E2F1/CDK6/AKT1/RAF1/E2F2/MTOR/ARAF/AKT2/PIK3CB	0.641045519124172
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1477	35/9376	1.26960054163846	HK1/ENOSF1/AKR1B1/PFKL/PFKFB4/PFKP/GMDS	0.690952075093472
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1477	18/9376	1.41066726848717	CBR4/FASN/MECR/MCAT	0.75409255067916
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1477	18/9376	1.41066726848717	FUCA2/GLB1/GBA2/MAN2B2	0.75409255067916
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/1477	205/9376	1.08380534042307	HLA-G/MYC/CCNA2/CCND3/PSMD1/HDAC2/PDIA3/PSMD14/CCNE1/PSMD2/HDAC1/CALR/PSMC1/PSMC2/PSMD6/PSMD11/PIK3R1/SKP2/CDK2/PIK3R3/E2F3/EIF2AK2/E2F1/CDK6/AKT1/E2F2/MAP3K7/AKT2/TRAF2/PIK3CB/NEDD4/CCNE2/FADD/IRAK4/TAB1	0.524602199713361
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1477	36/9376	1.23433385992628	HK1/UGP2/GPI/PYGL/AGL/PGM2/PGM1	0.609119758740591
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1477	48/9376	1.19025050778605	HK1/ATP1B2/SLC37A4/PIK3R1/ATP1A1/PIK3R3/AKT1/AKT2/PIK3CB	0.571402325459554
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/1477	200/9376	1.07916046039269	TUBA1B/TUBB/GAPDH/TUBB6/NCL/TUBA1C/RPS3/MYH10/ITGB1/ARPC1A/PAK2/PTPN11/ROCK1/FYN/CLDN7/CTTN/ROCK2/ARHGEF12/EZR/IL1R1/CLDN4/NCKAP1/MAP3K7/BAIAP2L1/WASF1/TRAF2/MYO1B/CLDN10/MYO10/CLDN19/CLDN6/FADD/IRAK4/TAB1	0.489312641165634
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1477	60/9376	1.16380049650192	PIK3R1/KRAS/PIK3R3/PPP3CA/RAC3/AKT1/RAF1/NFATC2/PXN/AKT2/PIK3CB	0.550384162002351
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/1477	109/9376	1.10653258216196	CD36/PPP1CA/PPP1CC/PTPN11/NR1H2/PIK3R1/PIK3R3/CREB1/SLC27A2/PYGL/MLX/AKT1/MTOR/AKT2/GSK3B/TBC1D4/RPS6KA3/PIK3CB/PRKCZ	0.483744399529854
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	31/1477	183/9376	1.07534472105989	RAN/RPP30/FBL/POP7/POP5/DKC1/XPO1/GAR1/RRP7A/XRN2/RIOK1/RBM28/BMS1/MDN1/GNL3/WDR36/UTP18/UTP6/RIOK2/UTP14C/UTP14A/NMD3/REXO1/SNORD3A/POP1/HEATR1/WDR3/NAT10/NVL/TBL3/DROSHA	0.445081530852608
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1477	31/9376	1.22864568545657	HADHA/ABAT/ALDH9A1/ALDH7A1/CNDP2/HIBCH	0.551371144115992
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1477	31/9376	1.22864568545657	SPCS3/SRPRB/SRP72/SRP9/SRP19/IMMP2L	0.551371144115992
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1477	37/9376	1.20097348533367	ADH5/FAH/PNMT/GOT2/MIF/GSTZ1/COMT	0.529638159235863
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	31/1477	184/9376	1.06950045627153	ITGB1/PAK2/PTPN11/ROCK1/PIK3R1/FYN/KRAS/EFNA1/ROCK2/ARHGEF12/SSH2/PIK3R3/FES/PPP3CA/RAC3/ENAH/RAF1/NFATC2/GNAI1/PAK4/GSK3B/LRRC4/PIK3CB/RGS3/RYK/ROBO1/SEMA6A/FZD3/SRGAP2/PRKCZ/SEMA4C	0.411700494235543
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1477	80/9376	1.11090047393365	GAB1/PIK3R1/KRAS/BCL2L1/PIK3R3/JAK2/AKT1/RAF1/MTOR/ARAF/AKT2/NF1/GSK3B/PIK3CB	0.43074492271746
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	18/1477	105/9376	1.08822903569011	SAMM50/VCP/TOMM40/USP15/MTX2/RHOT1/HUWE1/MFN1/KRAS/OPA1/USP8/BCL2L1/E2F1/RHOT2/TRAF2/CCZ1B/PGAM5/ATG9A	0.393126862668559
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1477	99/9376	1.09006107110373	MMP2/PIK3R1/NCOR1/KRAS/CDKN2C/PIK3R3/E2F3/E2F1/AKT1/RAF1/E2F2/MED1/MTOR/ARAF/AKT2/ADCY7/PIK3CB	0.389529860821816
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1477	32/9376	1.19025050778605	ATG10/MLST8/ATG4D/MTOR/PIK3R4/ATG9A	0.466148432111981
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1477	87/9376	1.09448322555039	MYL4/COX6C/MT-CO3/ATP1B2/TPM1/MT-CO1/COX5A/UQCRFS1/MT-CO2/UQCRH/TPM2/TPM4/ATP1A1/CACNG3/SLC9A6	0.382842095767132
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/1477	138/9376	1.05800045136538	ITGB1/ARPC1A/ROCK1/ITGA4/PIK3R1/ROCK2/ARHGEF12/PIK3R3/ITGA5/RAC3/AKT1/NFATC2/MAP3K7/PXN/AKT2/TRAF2/GSK3B/PIP5K1A/RPS6KA3/PIK3CB/IRAK4/TAB1/DOCK1	0.296805378382531
Organismal Systems	Immune system	hsa04611	Platelet activation	21/1477	126/9376	1.05800045136538	TLN1/ITGB1/PPP1R12A/PPP1CA/PPP1CC/ROCK1/COL1A1/PIK3R1/COL3A1/FYN/COL1A2/ROCK2/ARHGEF12/PIK3R3/AKT1/GNAI1/AKT2/ARHGAP35/ADCY7/PIK3CB/PRKCZ	0.28342333788716
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/1477	227/9376	1.0346964766657	HLA-G/MYC/CALM3/PDIA3/CALR/GNG2/ROCK1/PIK3R1/KRAS/CTNNB1/ROCK2/ARHGEF12/PIK3R3/E2F3/E2F1/CREB1/IL1R1/PPP3CA/RAC3/CDK6/AKT1/RAF1/E2F2/NFATC2/GNAI1/GNG12/MTOR/GNG3/PXN/AKT2/TRAF2/GSK3B/ATF6B/ADCY7/PIK3CB/FADD/GNG4	0.228823866293694
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1477	71/9376	1.07290186617334	CGA/STAT5B/PIK3R1/KRAS/CISH/PIK3R3/JAK2/AKT1/RAF1/AKT2/GSK3B/PIK3CB	0.266624135487531
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1477	53/9376	1.07796272403265	AP2A1/DNM2/ATP1B2/AP2M1/CLTC/ATP2B1/ATP1A1/ATP2B4/PTH1R	0.246114344424606
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/1477	122/9376	1.04065618167087	PAK2/PTPN11/PPP2R1B/PIK3R1/PPP2R5E/FYN/KRAS/PIK3R3/CBLB/DLG1/PPP3CA/PPP2R3B/AKT1/RAF1/NFATC2/PAK4/MAP3K7/AKT2/GSK3B/PIK3CB	0.195448159466422
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/1477	79/9376	1.0446080405886	AP2A1/DNM2/AP2M1/CLTC/STX2/ATP6V0A2/ATP6V1A/ATP6V0A1/SLC6A9/ATP6V1H/ATP6V1C2/ATP6V0E2/NSF	0.172165094921229
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1477	29/9376	1.09448322555039	MOB1B/SAV1/NF2/WWTR1/YAP1	0.220347139888097
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/1477	137/9376	1.01938729620606	TUBA1B/BIRC5/TUBA1C/LMNB1/PARP1/HTRA2/LMNB2/CASP2/PIK3R1/AIFM1/KRAS/BCL2L1/PIK3R3/AKT1/RAF1/AKT2/TRAF2/PIK3CB/PARP2/ATM/FADD/CTSV	0.0988450384374438
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1477	42/9376	1.05800045136538	TF/TFRC/VDAC3/GSS/STEAP3/SLC11A2/LPCAT3	0.162896573525673
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1477	17/9376	1.12023577203393	TFRC/MYH10/DAG1	0.214552343374264
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1477	158/9376	1.00443080825827	STRADB/ATP6V1A/PIK3R1/SKP2/KRAS/SEH1L/TBC1D7/MAPKAP1/MLST8/PIK3R3/LRP6/ATP6V1H/AKT1/TELO2/RAF1/MTOR/AKT2/GSK3B/TTI1/FZD5/RPS6KA3/PIK3CB/ATP6V1C2/WNT7A/FZD3	0.0242875091385294
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1477	43/9376	1.03339578970572	CD36/ACAT2/GOT2/AGPAT1/PLA2G2A/ACAT1/PLA2G10	0.0949085069679337
Genetic Information Processing	Translation	hsa03010	Ribosome	35/1477	222/9376	1.00081123777806	RPLP0/RPSA/RPL10A/RPS9/MRPL23/RPS3/RPL4/MRPS25/MRPL16/MRPL13/RPS4X/MRPL42/MRPL15/MRPL3/MRPL17/MRPL35/MRPL14/MRPL37/RPL3/MRPS35/MRPL19/RPL22L1/MRPL48/RPL7A/MRPS31/MRPS28/RPL6/MRPS27/MRPS9/RPS8/MRPS30/RPL14/MRPL44/RPS2/RPL5	0.00528943188674118
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1477	24/9376	1.05800045136538	GLCE/HS2ST1/EXTL2/EXT2	0.123019674624642
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	75/1477	480/9376	0.991875423155044	TUBA1B/TUBB/SNCA/COX6C/NDUFA4/TUBB6/VDAC3/PSMD1/CALM3/HSD17B10/TUBA1C/DCTN3/MT-CO3/PSMD14/PSMA4/VDAC1/NDUFS5/PSMD2/CAT/NDUFC2/HTRA2/MT-CO1/COX5A/VCP/PSMA1/TRAP1/PSMC1/PSMC2/PARK7/UQCRFS1/TOMM40/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/NDUFB11/PSMD6/NDUFA10/SLC25A5/MT-CO2/PSMD11/UQCRH/NDUFS2/MFN1/NDUFS1/KRAS/CTNNB1/MT-ND6/PPID/GPX8/UBA1/APC/BCL2L1/CHMP2B/SDHC/ATF6/PPP3CA/LRP6/RAF1/WDR41/MTOR/IFT57/ARAF/TRAF2/GSK3B/FZD5/DNAH14/PIK3R4/WNT7A/NEFH/FADD/FZD3/AXIN1/AXIN2	-0.0790157763013985
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	39/1477	250/9376	0.990288422477996	HLA-G/HSPA8/TFRC/AP2A1/DNM2/AP2M1/VPS29/ARPC1A/SNX5/CLTC/SNX4/IQSEC1/RAB11FIP1/SMAP2/VTA1/CAV1/SMAP1/EPN2/USP8/CHMP2B/CBLB/VPS36/RAB11FIP2/ARF3/EPN1/LDLR/GRK6/CHMP6/CAV2/PIP5K1A/FOLR1/EEA1/IGF2R/GBF1/DNAJC6/NEDD4/ARFGEF1/IL2RB/PRKCZ	-0.0672991195126678
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1477	51/9376	0.995765130696828	PDIA4/ATP6V0A2/ATP6V1A/ATP6V0A1/ATP6V1H/ATP6V1C2/ATP6V0E2/KDELR3	-0.0131126511814113
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/1477	90/9376	0.987467087941022	CAT/PIK3R1/APPL1/KRAS/PIK3R3/PPARG/CREB1/EHMT1/AKT1/MTOR/AKT2/ATF6B/ADCY7/PIK3CB	-0.0516593260820061
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1477	38/9376	1.00231621708299	NT5DC4/QPRT/NADK/NUDT12/NNT/SIRT5	0.00618634238983775
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1477	38/9376	1.00231621708299	ATP1B2/PIK3R1/KRAS/ATP1A1/PIK3R3/PIK3CB	0.00618634238983775
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1477	103/9376	0.986097508068704	COL18A1/ATP1B2/COL4A1/COL1A1/COL4A2/COL3A1/ATP1A1/COL1A2/SLC1A5/COL6A2/COL6A1/COL27A1/COL4A5/COL6A3/COL21A1/COL5A2	-0.0613466657096486
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/1477	142/9376	0.983493377325565	MGST3/MMP2/CALM3/TXN2/HSP90B1/PIK3R1/CAV1/CTNNB1/MGST1/PIK3R3/IL1R1/RAC3/GSTA4/KEAP1/AKT1/MAP3K7/SDC4/AKT2/CAV2/PIK3CB/GPC1/PRKCZ	-0.0857032497072175
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1477	45/9376	0.987467087941022	ABCB10/ABCA7/ABCG2/ABCD3/ABCB7/ABCC4/ABCB8	-0.0364404711477021
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1477	32/9376	0.991875423155044	BIRC5/HTRA2/BCL2L1/BIRC6/FADD	-0.0199066946097642
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	56/1477	362/9376	0.982011468670629	MYC/CCND3/CCNE1/ITGB1/YWHAH/YWHAQ/EPOR/HSP90B1/YWHAB/GNG2/PGF/RELN/YWHAE/BRCA1/COL4A1/PPP2R1B/COL1A1/ITGA4/PIK3R1/COL4A2/PPP2R5E/KRAS/EFNA1/FGFR1/LAMA4/COL1A2/CDK2/BCL2L1/MLST8/PIK3R3/CREB1/ITGA5/THEM4/COL6A2/PPP2R3B/CDK6/JAK2/COL6A1/AKT1/RAF1/LAMB1/GNG12/MTOR/GNG3/AKT2/GSK3B/LAMC1/ATF6B/PIK3CB/FLT4/CCNE2/COL4A5/COL6A3/IL2RB/ITGA1/GNG4	-0.150931901757395
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1477	65/9376	0.976615801260351	AGPAT5/AGPAT1/MBOAT2/AGPAT4/ALDH9A1/AGPAT3/AKR1B1/ALDH7A1/LCLAT1/GPAM	-0.0818033025559078
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1477	52/9376	0.976615801260351	CD36/VDAC3/VDAC1/STARD3NL/LDLR/STAR/PLTP/SORT1	-0.0731160736638805
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1477	59/9376	0.968339396164924	CGA/PIK3R1/PIK3R3/PDE3B/AKT1/GNAI1/AKT2/ADCY7/PIK3CB	-0.105486523729169
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	30/1477	196/9376	0.971633067580451	HLA-G/MYC/CALM3/GNG2/PIK3R1/KRAS/CTNNB1/PIK3R3/E2F3/EIF2AK2/E2F1/CREB1/PPP3CA/CDK6/JAK2/AKT1/RAF1/E2F2/NFATC2/TCF7L2/GNG12/MTOR/GNG3/AKT2/TRAF2/GSK3B/RCAN1/PIK3CB/FADD/GNG4	-0.173543718204528
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1477	33/9376	0.961818592150346	STX2/STX8/VTI1A/STX17/BNIP1	-0.0950069907339257
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1477	47/9376	0.945447211858425	PKLR/HK1/PIK3R1/PIK3R3/MTOR/PIK3CB/PRKCZ	-0.162120585393635
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1477	20/9376	0.952200406228842	CMAS/UGP2/GMDS	-0.0925302905647131
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	32/1477	212/9376	0.958189088029024	TLN1/CALM3/ID1/ITGB1/PGF/PIK3R1/RAP1GAP/KRIT1/KRAS/CTNNB1/EFNA1/FGFR1/CTNND1/PIK3R3/RAC3/ENAH/AKT1/PRKD3/RAF1/GNAI1/AKT2/SIPA1L1/RAPGEF6/ADCY7/RALB/PIK3CB/MAGI3/CDH1/FLT4/PRKCZ/SIPA1/ADORA2B	-0.266259345147154
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1477	48/9376	0.925750394944708	CLDN7/LDLR/CLDN4/TGOLN2/CLDN10/CLDN19/CLDN6	-0.223002805547085
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/1477	75/9376	0.931040397201535	ATP1B2/HSP90B1/CGA/PDIA4/TTF2/ATP1A1/GPX8/CREB1/TTF1/ATF6B/ADCY7	-0.259268878908341
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1477	28/9376	0.906857529741754	ST8SIA1/B4GALT4/B4GALT1/B3GNT2	-0.213430874851172
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1477	21/9376	0.906857529741754	CHSY1/DSEL/CHPF	-0.184767393456338
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1477	136/9376	0.933529810028277	HSPA8/CCND3/CCNE1/STAT5B/PIK3R1/CDK2/BCL2L1/PIK3R3/EIF2AK2/CBLB/CDK6/AKT1/MAP3K7/AKT2/GSK3B/PIK3CB/CCNE2/FADD/IL2RB/IRAK4	-0.337637143609355
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1477	103/9376	0.92446641381441	ACTN4/COL4A1/COL1A1/PIK3R1/COL4A2/COL3A1/LAMA4/COL1A2/PIK3R3/IL1R1/LAMB1/SERPINB9/LAMC1/PIK3CB/COL4A5	-0.333302380931239
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/1477	90/9376	0.916933724516663	PTPN11/PIK3R1/KRAS/PIK3R3/PPP3CA/JAK2/AKT1/RAF1/NFATC2/MTOR/AKT2/EML4/PIK3CB	-0.342390323287821
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/1477	63/9376	0.906857529741754	CTNNB1/APC/TCF7L2/GSK3B/FZD5/WNT7A/FZD3/AXIN1/AXIN2	-0.320747333050389
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	25/1477	170/9376	0.933529810028277	TUBA1B/PCNA/TUBA1C/MYH10/ITGB1/ARPC1A/ACTN4/RDX/ROCK1/PPP2R1B/CLDN7/CTTN/ROCK2/EZR/DLG1/CLDN4/NF2/JAM3/MPDZ/RAPGEF6/CLDN10/CLDN19/CLDN6/NEDD4/PRKCZ	-0.37818624086961
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1477	70/9376	0.906857529741754	CD36/PTPN11/APPL1/LEP/JAK2/AKT1/LEPR/MTOR/AKT2/TRAF2	-0.338224510294292
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1477	22/9376	0.865636732935311	ALDH9A1/ALDH7A1/CNDP2	-0.272824295114473
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/1477	125/9376	0.914112389979689	ROCK1/PPP2R1B/PIK3R1/SGMS1/PPP2R5E/FYN/KRAS/ROCK2/PIK3R3/PPP2R3B/RAC3/AKT1/RAF1/GNAI1/AKT2/TRAF2/PIK3CB/PRKCZ	-0.418004553583688
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1477	15/9376	0.846400361092304	AK2/AK4	-0.25743318541485
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	24/1477	166/9376	0.917783524075993	VDAC3/CALM3/ATP1B2/VDAC1/PPP1R12A/PPP1CA/GTF2I/ATP2B1/SLC25A5/PPP1CC/ROCK1/ATP1A1/ROCK2/CREB1/PDE3B/PPP3CA/AKT1/RAF1/NFATC2/GNAI1/AKT2/ATF6B/ADCY7/ATP2B4	-0.462139314039202
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1477	99/9376	0.897697352673656	SLC22A4/LYPLA1/PIK3R1/SLC44A2/KRAS/PIK3R3/RAC3/AKT1/RAF1/MTOR/WASF1/AKT2/PIP5K1A/PIK3CB	-0.442476815857965
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1477	86/9376	0.88576781974776	ITGB1/DSP/DSC2/ITGA4/CTNNB1/DSG2/ITGA5/DAG1/TCF7L2/PKP2/CACNG3/ITGA1	-0.46017144239268
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/1477	120/9376	0.899300383660573	CALM3/YWHAE/PTPN11/GAB1/PIK3R1/KRAS/MAGED1/PIK3R3/KIDINS220/AKT1/RAF1/AKT2/GSK3B/RPS6KA3/PIK3CB/SORT1/IRAK4	-0.480061187308925
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1477	23/9376	0.828000353242472	GOT2/ASL/GPT2	-0.357113143602246
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1477	107/9376	0.889906921709198	LDHB/LDHA/CALM3/PDHA1/PDHB/PHKB/CREB1/PFKL/PDE3B/PYGL/PPP3CA/AKT1/AKT2/PHKG2/PFKP	-0.495250920964155
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1477	16/9376	0.793500338524035	GOT2/MIF	-0.357463118595731
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1477	16/9376	0.793500338524035	ST8SIA1/ST3GAL2	-0.357463118595731
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1477	89/9376	0.855910477509072	SLC38A5/TRAK2/GNG2/ABAT/SLC38A1/GNAI1/GNG12/GNG3/ADCY7/GPHN/NSF/GNG4	-0.590581055418805
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1477	61/9376	0.832524945336693	TF/ATP1B2/ATP2B1/ATP1A1/SLC11A2/SLC39A4/ATP2B4/CYBRD1	-0.567431504958425
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1477	17/9376	0.746823848022621	SCP2/HSD17B4	-0.451775172848691
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1477	17/9376	0.746823848022621	MTR/SEPHS1	-0.451775172848691
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1477	17/9376	0.746823848022621	CA2/CA8	-0.451775172848691
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1477	69/9376	0.828000353242472	PIK3R1/FYN/KRAS/PIK3R3/RAC3/AKT1/RAF1/AKT2/PIK3CB	-0.620064792049446
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1477	55/9376	0.80792761740629	UGCG/SGMS1/SMPD4/B4GALT5/GLB1/KDSR/GBA2	-0.617738747773376
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1477	98/9376	0.842081991903058	CALM3/ATP1B2/ATP2B1/ATP1A1/CYP11A1/CREB1/HSD3B1/LDLR/PRKD3/STAR/ATF6B/ADCY7/ATP2B4	-0.679527974183406
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1477	91/9376	0.837099258223158	PIK3R1/KRAS/PIK3R3/PPP3CA/RAC3/AKT1/RAF1/NFATC2/AKT2/GSK3B/PIK3CB/IFITM1	-0.675215857160612
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/1477	133/9376	0.859128186071136	CALM3/GNG2/PPP1CA/PPP1CC/PPP2R1B/PPP2R5E/CREB1/PPP3CA/PPP2R3B/AKT1/GNAI1/GNG12/GNG3/AKT2/GSK3B/ATF6B/COMT/GNG4	-0.70751113569118
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	21/1477	154/9376	0.865636732935311	MYL4/CALM3/ATP1B2/TPM1/PPP1CA/ATP2B1/PPP1CC/TPM2/PPP2R1B/PPP2R5E/TPM4/ATP1A1/CREB1/PPP2R3B/AKT1/GNAI1/AKT2/ATF6B/ADCY7/CACNG3/ATP2B4	-0.726972839856481
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	23/1477	169/9376	0.863929362653387	HMGB1/PIK3R1/EIF2AK4/ATG10/KRAS/BCL2L1/MLST8/PIK3R3/ATG4D/BIRC6/VPS16/AKT1/RAF1/WDR41/VPS41/MAP3K7/MTOR/STX17/GORASP2/AKT2/PIK3CB/PIK3R4/ATG9A	-0.771859988533519
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	30/1477	217/9376	0.877604061040408	BIRC5/MYC/MGST3/CCND3/KPNB1/KPNA2/HSP90B1/CDC6/CDC25A/KPNA3/STAT5B/PIK3R1/KRAS/KPNA6/MGST1/PIK3R3/E2F1/CREB1/JAK2/GSTA4/AKT1/RAF1/GNAI1/MTOR/AKT2/ATF6B/RPS6KA3/ADCY7/PIK3CB/KLF5	-0.788792322233795
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/1477	149/9376	0.852080900428494	NDUFA4/NDUFS5/NDUFC2/GNG2/NDUFV1/NDUFS4/NDUFB2/NDUFA9/NDUFS7/NDUFB11/NDUFA10/NDUFS2/NDUFS1/MT-ND6/NAPEPLD/GNAI1/GNG12/GNG3/ADCY7/GNG4	-0.787004031939176
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/1477	115/9376	0.828000353242472	GNG2/PIK3R1/FYN/KRAS/PIK3R3/CREB1/JAK2/AKT1/GNAI1/GNG12/GNG3/AKT2/ADCY7/PIK3CB/GNG4	-0.802485810538046
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1477	115/9376	0.828000353242472	EGR1/GCM1/MMP15/OXSR1/FGFR1/GATA3/CREB1/MMP14/LRP6/RAF1/GNAI1/ARAF/ATF6B/ADCY7/PTH1R	-0.802485810538046
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1477	65/9376	0.781292641008281	CGA/PIK3R1/KRAS/PIK3R3/AKT1/RAF1/AKT2/PIK3CB	-0.765088616377012
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/1477	157/9376	0.849095903643554	CD36/EPOR/CALR/BSG/UQCRFS1/SLC16A1/PTPN11/NR1H2/CD47/DNMT3A/ATP11A/PPARG/CREB1/JAK2/ATP11C/VPS16/NFATC2/VPS41/PROS1/ATP11B/DOCK1	-0.824515409594964
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1477	19/9376	0.668210811388661	GUSB/GLB1	-0.625980125830108
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	34/1477	248/9376	0.870290693865071	TUBA1B/TUBB/MYC/GAPDH/TUBB6/TUBA1C/DCTN3/TXN2/RPS3/DNM2/ARPC1A/HSP90B1/CSE1L/EXOC5/KPNA3/PODXL/DYNC1I2/CTNNB1/ROCK2/VPS16/AKT1/RAF1/TCF7L2/NCKAP1/VPS41/MAP3K7/AKT2/TRAF2/PIK3CB/FADD/IRAK4/GSDMD/EXOC2/TAB1	-0.895156541689255
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1477	67/9376	0.757970472619974	CALM3/PPP1CA/PPP1CC/KRAS/PPP3CA/RAF1/ARAF/RPS6KA3	-0.859694340820081
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1477	52/9376	0.732461850945263	CGA/CYP11A1/HSD3B1/LDLR/STAR/ADCY7	-0.836519533210139
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1477	139/9376	0.822043516168785	HSPA8/MMP2/CALM3/HSP90B1/PIK3R1/NCOA1/KRAS/KRT23/PIK3R3/CREB1/AKT1/RAF1/GNAI1/AKT2/FKBP5/ATF6B/ADCY7/PIK3CB	-0.913998690205176
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	22/1477	168/9376	0.831286068929942	MYC/CCND3/EPOR/PIM1/PTPN11/STAT5B/PIK3R1/LEP/CISH/LIFR/BCL2L1/PIK3R3/JAK2/AKT1/LEPR/RAF1/IL15RA/MTOR/AKT2/PIK3CB/IL2RB/PIAS2	-0.954141441704252
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/1477	140/9376	0.816171776767579	MYL4/CALM3/EGR1/GNG2/TFAM/KRAS/PDE3B/AKT1/RAF1/GNAI1/GNG12/MTOR/GNG3/AKT2/ADCY7/CDH1/PIK3R4/GNG4	-0.947597866536222
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/1477	133/9376	0.811398842400517	CCNB2/CCNB1/CAT/PLK1/PIK3R1/SKP2/PLK4/KRAS/CDK2/PIK3R3/AKT1/RAF1/ARAF/AKT2/PIK3CB/ATM/NLK	-0.947225818170148
NA	NA	hsa04382	Cornified envelope formation	29/1477	217/9376	0.848350592339061	UGCG/ELOVL1/COL4A1/DSP/PPP2R1B/KRT7/COL4A2/PPP2R5E/BLMH/CLDN7/KRT8/KRT23/PRSS8/DSG2/FURIN/PPP2R3B/CLDN4/PKP3/PKP2/CLDN10/KDSR/CLDN19/CLDN6/TGM1/PCSK6/GBA2/S100A11/COL4A5/PADI1	-0.97731909613229
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/1477	112/9376	0.793500338524035	HSPA8/ITGB1/LAMA4/BCL2L1/LDLR/JAK2/AKT1/LAMB1/GNAI1/MAP3K7/AKT2/LAMC1/IRAK4/TAB1	-0.950646188135496
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/1477	83/9376	0.76481960339666	POLR3K/POLR2H/G3BP1/POLR3H/POLR3B/DDX41/POLR3A/POLR3E/FADD/GSDMD	-0.930576379892273
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1477	105/9376	0.785943192442854	CALM3/PTPN11/PIK3R1/KRAS/ARHGEF12/PIK3R3/CBLB/PPP3CA/AKT1/RAF1/NFATC2/AKT2/PIK3CB	-0.953784437623922
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/1477	155/9376	0.819097123637714	TUBA1B/TUBB/HLA-G/CD36/TFRC/TUBB6/TUBA1C/ITGB1/CALR/MRC2/ATP6V0A2/ATP6V1A/ATP6V0A1/DYNC1I2/ITGA5/ATP6V1H/EEA1/ATP6V1C2/C1R/ATP6V0E2	-0.982001473003312
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1477	21/9376	0.604571686494503	AASDHPPT/PANK2	-0.784414012025611
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1477	98/9376	0.777306454064361	CALM3/PLCD1/PPIP5K2/PIK3R1/IMPA2/PIK3R3/PI4KA/CDS2/PIP5K1A/PIK3CB/MTMR2/SYNJ1	-0.958259896746344
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/1477	98/9376	0.777306454064361	DNM2/ARPC1A/PIK3R1/PIK3R3/AKT1/RAF1/WASF1/AKT2/PIP5K1A/PIK3CB/MYO10/DOCK1	-0.958259896746344
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/1477	134/9376	0.805343627158722	CALM3/MYH10/PPP1R12A/CALD1/PPP1CA/PPP1CC/ROCK1/ROCK2/ARHGEF12/PLA2G2A/RAF1/ARAF/PLA2G10/ADCY7/PPP1R12B/RAMP1/ADORA2B	-0.981358916246074
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/1477	253/9376	0.853091273037698	CBX3/TLN1/HK1/VDAC1/ITGB1/ARPC1A/UBE2N/ACTN4/PLCD1/U2AF1/ROCK1/PIK3R1/CTTN/PPID/ROCK2/BCL2L1/PIK3R3/ITGA5/IL1R1/CUL1/AKT1/BTRC/MAP3K7/MTOR/WASF1/PXN/AKT2/TRAF2/GSK3B/PIK3CB/PIK3R4/ATM/TAB1/DOCK1	-1.02430394998534
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1477	69/9376	0.736000313993308	HDAC2/CALM3/HDAC1/PPP1CA/PPP1CC/CREB1/PPP3CA/ATF6B	-0.951728177881816
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/1477	149/9376	0.809476855407069	DNM2/AGPAT5/PTPN11/GAB1/PIK3R1/AGPAT1/FYN/KRAS/AGPAT4/PIK3R3/AGPAT3/AKT1/RAF1/MTOR/AKT2/PIP5K1A/ADCY7/RALB/PIK3CB	-1.01367898673479
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	25/1477	193/9376	0.822280143548223	GNG2/ROCK1/STAT5B/PIK3R1/KRAS/ROCK2/PIK3R3/RAC3/JAK2/CXCL14/AKT1/RAF1/GNAI1/GNG12/GRK6/GNG3/PXN/AKT2/GSK3B/ADCY7/PIK3CB/CCL28/CCR7/PRKCZ/GNG4	-1.07872848044335
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1477	122/9376	0.780492136253149	STAT5B/PIK3R1/KRAS/PIK3R3/CREB1/JAK2/AKT1/RAF1/GNAI1/MTOR/AKT2/GSK3B/ATF6B/ADCY7/PIK3CB	-1.05524931743582
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/1477	78/9376	0.732461850945263	PLCD1/PPIP5K2/IMPA2/PI4KA/MINPP1/PIP5K1A/PIK3CB/MTMR2/SYNJ1	-1.0259544451217
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1477	31/9376	0.614322842728285	ALDH9A1/ALDH7A1/GUSB	-0.930047094655107
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1477	71/9376	0.715267910782229	ATP6V0A2/ATP6V1A/PTPN11/ATP6V0A1/ATP6V1H/JAM3/ATP6V1C2/ATP6V0E2	-1.04135121798852
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1477	101/9376	0.754218143547598	CALM3/KRAS/CTNNB1/CREB1/RAF1/TCF7L2/GNAI1/GSK3B/FZD5/ADCY7/WNT7A/FZD3	-1.07384939532886
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1477	56/9376	0.680143147306316	SPOP/CSNK1G2/CSNK1G3/CUL1/BTRC/GSK3B	-1.03808172576878
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1477	23/9376	0.552000235494981	B4GALT1/CHST10	-0.930156586082935
NA	NA	hsa04519	Cadherin signaling	55/1477	404/9376	0.864208289481623	DAAM1/YWHAH/YWHAQ/ARPC1A/ACTN4/TMC6/YWHAB/LIMA1/YWHAE/PPP1CA/PPP1CC/DSP/ROCK1/DSC2/KRT7/MOB1B/SAV1/KRAS/CTNNB1/FGFR1/KRT8/CTNND1/RERE/ROCK2/KRT23/APC/DSG2/ABI2/RAC3/ENAH/LRP6/RAF1/NF2/TCF7L2/NCKAP1/WWTR1/WASF1/MPDZ/GSK3B/FZD5/PKP3/ARHGAP35/PKP2/MYO1B/TMC8/CDH1/FLT4/ATN1/RYK/VANGL1/WNT7A/YAP1/FZD3/AXIN1/AXIN2	-1.20644947298467
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1477	65/9376	0.683631060882246	CYP11A1/CREB1/HSD3B1/LDLR/STAR/ATF6B/ADCY7	-1.10673127328756
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/1477	119/9376	0.746823848022621	DNM1L/PIK3R1/PIK3R3/CREB1/MMP14/AKT1/MAP3K7/AKT2/TRAF2/ATF6B/PIK3CB/PGAM5/FADD/TAB1	-1.20185195019697
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1477	50/9376	0.634800270819228	GYPB/GYPA/GYPC/CD36/CR1L	-1.11958629186701
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1477	82/9376	0.696732004557689	HLA-G/HSPA8/PDIA3/CALR/HSPA2/NFYB/PSME3/CREB1/RFXAP	-1.19267468619874
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1477	34/9376	0.560117886016966	CREB1/CUL1/BTRC	-1.11108084262188
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1477	51/9376	0.622353206685518	PAFAH1B3/PLA2G2A/AGPS/PAFAH1B2/PLA2G10	-1.16932786256304
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/1477	216/9376	0.793500338524035	CD36/HSPA8/HSPD1/CALM3/HSP90B1/PIK3R1/HSPA2/KRAS/ROCK2/BCL2L1/MIB1/PIK3R3/PPARG/ATF6/PPP3CA/LDLR/JAK2/AKT1/NFATC2/POU2F1/MAP3K7/AKT2/TRAF2/GSK3B/PIK3CB/IRAK4/TAB1	-1.32766440453093
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1477	99/9376	0.705333634243587	CALM3/ASIC4/PPP1CA/PPP1CC/PIK3R1/PIK3R3/ALOX12/IL1R1/IL1RAP/ADCY7/PIK3CB	-1.27448349253775
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1477	76/9376	0.668210811388661	CA2/CALM3/ATP1B2/ATP1A1/EZR/GNAI1/ADCY7/GAST	-1.25579104324956
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1477	26/9376	0.488307900630176	PLA2G2A/PLA2G10	-1.12974234925435
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1477	26/9376	0.488307900630176	SLC19A1/LMBRD1	-1.12974234925435
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1477	36/9376	0.52900022568269	UGP2/AKR1B1/GUSB	-1.22430138345902
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1477	62/9376	0.614322842728285	HDAC2/HDAC1/CTBP2/CTBP1/KAT2B/SPEN	-1.31747224362054
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/1477	142/9376	0.715267910782229	PIK3R1/FYN/PIK3R3/FHL2/PPARG/CREB1/IL1R1/PPP3CA/TMEM64/AKT1/NFATC2/MAP3K7/AKT2/TRAF2/PIK3CB/TAB1	-1.47834392432571
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	41/1477	323/9376	0.805783625498091	MYC/DNMT1/HDAC2/STMN1/EZH2/CCNE1/TPM1/KIF23/HDAC1/CDCA5/BRCA1/RDX/PIM1/CDC25A/IGF2BP1/ROCK1/PIK3R1/KRAS/SOX4/EFNA1/MDM4/DNMT3A/APC/PIK3R3/E2F3/EZR/E2F1/ITGA5/SLC7A1/CDK6/CDC25C/RAF1/E2F2/PAK4/MTOR/CDC25B/PIK3CB/ATM/DNMT3B/CCNE2/FZD3	-1.5359627122017
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	29/1477	238/9376	0.773496128309143	CALM3/RALBP1/GNG2/PGF/PAK2/PTPN11/GAB1/PIK3R1/KRAS/EFNA1/FGFR1/BCL2L1/PIK3R3/PLA2G2A/RAC3/AKT1/RAF1/PAK4/GNG12/GNG3/AKT2/NF1/PLA2G10/RALB/PIK3CB/ETS2/FLT4/GNG4/EXOC2	-1.53048247331377
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1477	38/9376	0.501158108541496	UNG/DCLRE1C/RFXAP	-1.33234780177443
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1477	56/9376	0.566785956088596	HSPA8/HSPD1/HSF1/CR1L/VCP	-1.40597763825775
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/1477	89/9376	0.641932858131804	TUBA1B/TUBB/CDK1/TUBB6/TUBA1C/KRAS/RAF1/GNAI1/ADCY7	-1.46761309843766
NA	NA	hsa04517	IgSF CAM signaling	37/1477	299/9376	0.785538796665935	TUBA1B/TUBB/TUBB6/TUBA1C/MYH10/ITGB1/ARPC1A/ACTN4/RDX/PAK2/PTPN11/ITGA4/PIK3R1/CD2AP/FYN/CTNNB1/FGFR1/PIK3R3/EZR/ITGA5/AKT1/CABLES2/PAK4/ERC1/JAM3/IL1RAP/MPDZ/PXN/AKT2/GSK3B/RAPGEF6/PIK3CB/CDH1/PTPRS/ROBO1/CADM3/SRGAP2	-1.6296824694513
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/1477	91/9376	0.627824443667369	GNG2/PDE3B/GNAI1/GNG12/GRK6/GNG3/ADCY7/GNG4/PDE7A	-1.54265004899499
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1477	30/9376	0.423200180546152	PLA2G2A/PLA2G10	-1.36824126339166
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/1477	76/9376	0.584684459965079	CD36/SCP2/ACADM/HMGCS1/PPARG/SLC27A2/PLTP	-1.57193047031185
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/1477	93/9376	0.614322842728285	MMP2/CALM3/EGR1/CGA/KRAS/MAP3K4/MMP14/RAF1/ADCY7	-1.61625933188612
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1477	201/9376	0.726388369594142	LMO2/MYC/CCNA2/HDAC2/MLLT3/DDX5/HDAC1/TAF15/EWSR1/LDB1/BMP2K/NCOR1/CDKN2C/RUNX1T1/TCF3/MYCN/BCL2L1/PPARG/KMT2A/ELK4/FUT8/ATM/IL2RB	-1.69558425529227
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/1477	60/9376	0.52900022568269	PPP2R1B/KRAS/RAF1/GNAI1/ARAF	-1.58260091774443
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/1477	94/9376	0.607787493337559	ANAPC5/HSP90B1/SRSF1/MAP3K7/TRAF2/GSK3B/USP25/FADD/TRAF4	-1.65254925159061
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/1477	69/9376	0.552000235494981	CALM3/AQP1/CREB1/PDE3B/PPP3CA/GNAI1	-1.61505494954655
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1477	78/9376	0.569692550735205	ITGB1/CR1L/ITGA4/JAK2/MAP3K7/IRAK4/TAB1	-1.65014164111554
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/1477	103/9376	0.61631094254294	CALR/PPP2R1B/PIK3R1/PIK3R3/AKT1/GNAI1/AKT2/PIK3CB/FADD/IRAK4	-1.69308095703919
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1477	70/9376	0.544114517845053	HLA-G/CAV1/EIF4G1/FYN/RAC3/DAG1	-1.65543863636668
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/1477	168/9376	0.680143147306316	HMGB1/PPIA/VDAC3/PARP1/VDAC1/DNM1L/SLC25A5/STAT5B/AIFM1/PPID/CHMP2B/EIF2AK2/PYGL/JAK2/CHMP6/TRAF2/PGAM5/FADD	-1.8089121427762
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1477	191/9376	0.697947941738418	SLC29A1/HDAC2/CALM3/HAT1/HDAC1/GNG2/PPP1CA/PPP1CC/KRAS/CREB1/PKIA/RAF1/GNAI1/GNG12/GNG3/ARAF/ATF6B/HDAC6/HDAC8/ADORA2B/GNG4	-1.82368040490057
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1477	105/9376	0.604571686494503	ITGB1/TPM1/TPM2/ITGA4/TPM4/ITGA5/DAG1/ADCY7/CACNG3/ITGA1	-1.76193121779941
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/1477	44/9376	0.432818366467656	DYNC1I2/CREB1/NSF	-1.63061322832674
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1477	63/9376	0.503809738745419	PTGDS/PLA2G2A/ALOX12/PLA2G10/PTGES2	-1.7086910250686
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/1477	154/9376	0.659532748903094	CALM3/PPP1R12A/PPP1CA/PPP1CC/ROCK1/KRAS/ROCK2/PPP3CA/RAF1/NFATC2/GNAI1/RCAN1/ADCY7/CACNG3/EEF2K/PPP1R12B	-1.84209903357652
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1477	90/9376	0.56426690739487	CA2/ATP1B2/ATP1A1/AQP1/ABCG2/LDLR/ABCC4/ADCY7	-1.79604530931689
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1477	23/9376	0.276000117747491	THOP1	-1.50320002856362
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/1477	99/9376	0.577091155290207	ITGB1/TPM1/TPM2/ITGA4/TPM4/ITGA5/DAG1/CACNG3/ITGA1	-1.82915461032427
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1477	100/9376	0.571320243737305	GYPA/CD36/TFRC/CR1L/EPOR/ITGA4/ITGA5/IL1R1/ITGA1	-1.86355594079536
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1477	173/9376	0.66048583091018	CCND3/FDPS/VDAC1/KPNA2/XPO1/SLC25A5/PIK3R1/KPNA6/PIK3R3/EIF2AK2/CDK6/JAK2/AKT1/RAF1/AKT2/PIK3CB/FADD/IRAK4	-1.94897412373026
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/1477	181/9376	0.666364925169356	HSPD1/CALM3/CR1L/MRC2/ATP6V0A2/NFYB/ATP6V0A1/ARHGEF12/CREB1/PPP3CA/JAK2/ATP6V1H/AKT1/RAF1/AKT2/RFXAP/EEA1/FADD/IRAK4	-1.95985955697733
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1477	66/9376	0.480909296075173	HSD17B12/CYP11A1/HSD3B1/SRD5A3/COMT	-1.82991201069286
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1477	37/9376	0.343135281523907	LAMA4/THOP1	-1.73107721042427
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/1477	144/9376	0.617166929963138	ADH5/ACADM/CTNNB1/ALDH9A1/ALDH7A1/FASN/AKT1/TCF7L2/MAP3K7/AKT2/GSK3B/FADD/IRAK4/TAB1	-2.00185502810701
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/1477	160/9376	0.634800270819228	HLA-G/ITGB1/ITGA4/CLDN7/CLDN4/GLG1/SDC4/JAM3/LRRC4/CLDN10/CDH1/CLDN19/CLDN6/PTPRS/CD276/CADM3	-2.01469372620654
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1477	26/9376	0.244153950315088	PKLR	-1.66879905493419
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1477	49/9376	0.388653227032181	CREB1/GNAI1/ATF6B	-1.85525881892587
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/1477	78/9376	0.488307900630176	CALM3/ITGB1/ITGA5/GNAI1/C1R/IRAK4	-1.96223523911246
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/1477	105/9376	0.544114517845053	PARP1/BCL2L1/IL1R1/MAP3K7/ERC1/TRAF2/ATM/IRAK4/TAB1	-2.03131347785791
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1477	50/9376	0.380880162491537	ITGA4/IL15RA/CCL28	-1.89802463614177
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1477	79/9376	0.482126787963971	MGST3/GSTK1/ADH5/AKR7A2/MGST1/GSTA4	-1.99873586758983
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	20/1477	195/9376	0.651077200840234	HMGB1/VDAC3/HDAC2/VDAC1/CR1L/HAT1/HDAC1/SLC25A5/PIK3R1/PIK3R3/AKT1/RAF1/CLCN4/MAP3K7/MTOR/AKT2/PIK3CB/HDAC6/HDAC8/GSDMD	-2.12907759027722
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/1477	97/9376	0.523546615108642	CALM3/GNG2/CREB1/GNAI1/GNG12/GNG3/ADCY7/GNG4	-2.03960245193884
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/1477	133/9376	0.572752124047424	HLA-G/PTPN11/PIK3R1/FYN/KRAS/PIK3R3/PPP3CA/RAC3/RAF1/NFATC2/ARAF/PIK3CB	-2.14579923056499
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1477	29/9376	0.218896645110079	CALM3	-1.82163436106648
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/1477	109/9376	0.524147012603033	PIK3R1/PIK3R3/AKT1/MAP3K7/AKT2/PIK3CB/FADD/IRAK4/TAB1	-2.16075883059778
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/1477	109/9376	0.524147012603033	STAT5B/GATA3/IL1R1/PPP3CA/JAK2/NFATC2/MTOR/IL1RAP/IL2RB	-2.16075883059778
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1477	73/9376	0.434794706040567	MGST3/GSTK1/ADH5/MGST1/GSTA4	-2.09626396829503
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/1477	102/9376	0.497882565348414	CA2/ATP1B2/ATP2B1/ATP1A1/PLA2G2A/PLA2G10/ADCY7/ATP2B4	-2.20476177318337
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	23/1477	226/9376	0.646035673842577	CALM3/ATP1B2/PPP1R12A/CGA/PPP1CA/ATP2B1/PPP1CC/ROCK1/PIK3R1/ATP1A1/ROCK2/PIK3R3/CREB1/PDE3B/RAC3/AKT1/RAF1/GNAI1/ABCC4/AKT2/ADCY7/PIK3CB/ATP2B4	-2.32912606684604
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1477	44/9376	0.288545577645104	HLA-G/HSPD1	-2.04538885580345
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/1477	115/9376	0.496800211945483	GNG2/KRAS/ALOX12/RAF1/GNAI1/GNG12/GNG3/ARAF/GNG4	-2.34774139012484
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1477	70/9376	0.362743011896702	MGST3/GSTK1/MGST1/GSTA4	-2.31404569940288
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/1477	300/9376	0.655960279846536	MYC/HSPA8/STMN1/PGF/PAK2/KRAS/MAP3K4/EFNA1/FGFR1/PPP5C/IL1R1/PPP3CA/RAC3/AKT1/RAF1/GNG12/MAP3K7/ARAF/ELK4/IL1RAP/AKT2/TRAF2/NF1/CDC25B/DUSP9/RPS6KA3/CACNG3/FLT4/IRAK4/NLK/TAB1	-2.61885708177879
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/1477	72/9376	0.352666817121793	AZI2/MAP3K7/TRAF2/FADD	-2.38423520413601
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1477	93/9376	0.409548561818857	STAT5B/GATA3/PPP3CA/JAK2/NFATC2/IL2RB	-2.47440800937433
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/1477	93/9376	0.409548561818857	CALM3/ATP1B2/ATP2B1/ATP1A1/ADCY7/ATP2B4	-2.47440800937433
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/1477	95/9376	0.400926486833197	ATP6V0A2/ATP6V1A/ATP6V0A1/ATP6V1H/ATP6V1C2/ATP6V0E2	-2.53766543219681
NA	NA	hsa04081	Hormone signaling	20/1477	219/9376	0.579726274720756	EPOR/GNG2/CGA/STAT5B/PIK3R1/APPL1/LEP/DIO2/PIK3R3/JAK2/LEPR/GNAI1/GNG12/GNG3/ADCY7/PIK3CB/GAST/RAMP1/PTH1R/GNG4	-2.72124421533468
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/1477	86/9376	0.3690699248949	ATP1B2/ATP1A1/CREB1/ATF6B/ADCY7	-2.54163058140828
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1477	39/9376	0.162769300210059	HLA-G	-2.26549755511669
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/1477	187/9376	0.543144616743725	VDAC3/TXN2/VDAC1/YWHAE/DNM1L/MFN1/BCL2L1/DHX33/MAP3K7/TRAF2/BRCC3/CARD8/FADD/IRAK4/GSDMD/TAB1	-2.72869662129458
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/1477	116/9376	0.437793290220157	GNG2/PPP3CA/SLC38A1/GNAI1/GNG12/GNG3/ADCY7/GNG4	-2.6345676494291
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	22/1477	238/9376	0.586790166303488	RPLP0/RPSA/RPL10A/RPS9/RPS3/RPL4/RPS4X/RPL3/RPL22L1/RPL7A/PIK3R1/RPL6/PIK3R3/RPS8/RPL14/EIF2AK2/RPS2/MAP3K7/PIK3CB/C1R/IRAK4/RPL5	-2.79205120668557
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1477	54/9376	0.235111211414529	HLA-G/CGA	-2.43742047397728
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1477	88/9376	0.36068197205638	TFPI/CR1L/PROCR/PROS1/C1R	-2.60547561441616
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1477	68/9376	0.280058943008483	ADH5/PNPLA4/RDH13	-2.57639851000753
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1477	45/9376	0.141066726848717	HLA-G	-2.49741903643596
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1477	100/9376	0.253920108327691	CXCL14/CCL28/IL2RB/CCR7	-3.24335729439455
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1477	66/9376	0.0961818592150346	GATA3	-3.18616314798043
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/1477	254/9376	0.424866322989247	VDAC3/CALM3/VDAC1/PLCD1/ATP2B1/SLC25A5/PHKB/FGFR1/PPP3CA/NFATC2/STIM2/ADCY7/MST1/PHKG2/ATP2B4/FLT4/ADORA2B	-4.01818984548965
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1477	143/9376	0.266349763980096	SNRPD1/SNRPB/ACTN4/SSB/TRIM21/C1R	-3.82274643076878
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/1477	99/9376	0.128242478953379	KRT23/C1R	-3.77050352257709
NA	NA	hsa04082	Neuroactive ligand signaling	8/1477	199/9376	0.255196088771549	GNG2/SLC6A9/GNAI1/GNG12/GNG3/ADCY7/ADORA2B/GNG4	-4.59206418690127
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/1477	298/9376	0.234322247617836	EPOR/LEP/LIFR/IL1R1/CXCL14/LEPR/IL15RA/IL1RAP/CCL28/IL2RB/CCR7	-5.80829813387574
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/1477	370/9376	0.137254112609563	TMEM97/CGA/PGRMC2/LEP/LEPR/PTH1R/ADORA2B/NMU	-7.32162729344745
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/1477	449/9376	0.0141380906641253	CALM3	-9.25712907336192