ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 119/2085 175/18639 0.68 6.07890647482014 1.62311914980563e-71 1.79679289883484e-68 GO:0019843 rRNA binding 39/2085 65/18639 0.6 5.36374100719424 3.0281587685961e-21 1.67608587841794e-18 GO:0045296 cadherin binding 89/2085 334/18639 0.266467065868263 2.38210054710722 2.2690696549687e-15 8.3728670268345e-13 GO:0043021 ribonucleoprotein complex binding 57/2085 177/18639 0.322033898305085 2.87884404340934 4.69313261621121e-14 1.29882445153645e-11 GO:0003712 transcription coregulator activity 101/2085 495/18639 0.204040404040404 1.82403313712666 1.16536223267792e-09 2.58011198314891e-07 GO:0003713 transcription coactivator activity 62/2085 256/18639 0.2421875 2.16505170863309 2.59097708376983e-09 4.78035271955534e-07 GO:0043022 ribosome binding 35/2085 112/18639 0.3125 2.79361510791367 8.55119308523308e-09 1.352310106479e-06 GO:0140297 DNA-binding transcription factor binding 97/2085 488/18639 0.198770491803279 1.77692239650902 1.00965774002404e-08 1.39711389775826e-06 GO:0048027 mRNA 5'-UTR binding 14/2085 24/18639 0.583333333333333 5.21474820143885 3.03713291350678e-08 3.11344164339853e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 25/2085 68/18639 0.367647058823529 3.2866060093102 3.08886050465209e-08 3.11344164339853e-06 GO:0044389 ubiquitin-like protein ligase binding 70/2085 322/18639 0.217391304347826 1.94338442289647 3.09375411719818e-08 3.11344164339853e-06 GO:0003743 translation initiation factor activity 21/2085 51/18639 0.411764705882353 3.68099873042742 3.88691005093298e-08 3.58567452198568e-06 GO:0031625 ubiquitin protein ligase binding 66/2085 302/18639 0.218543046357616 1.95368049930916 6.16146611118409e-08 5.24672537313907e-06 GO:0055106 ubiquitin-protein transferase regulator activity 17/2085 36/18639 0.472222222222222 4.22146282973621 6.68980115464396e-08 5.2897213415649e-06 GO:0008135 translation factor activity, RNA binding 27/2085 83/18639 0.325301204819277 2.90805235329808 1.67658462303528e-07 1.23731945180004e-05 GO:0180051 translation factor activity 27/2085 84/18639 0.321428571428571 2.87343268242549 2.20940304640951e-07 1.52863073273458e-05 GO:0009055 electron transfer activity 33/2085 116/18639 0.28448275862069 2.54315306375589 2.73081308236676e-07 1.77824122481177e-05 GO:0003954 NADH dehydrogenase activity 18/2085 44/18639 0.409090909090909 3.6570961412688 4.08311852814653e-07 2.51111789481011e-05 GO:0055105 ubiquitin-protein transferase inhibitor activity 10/2085 15/18639 0.666666666666667 5.95971223021583 5.30475488704056e-07 3.09071771576521e-05 GO:0061650 ubiquitin-like protein conjugating enzyme activity 17/2085 41/18639 0.414634146341463 3.70665028952448 6.80778753305741e-07 3.76811039954728e-05 GO:0031720 haptoglobin binding 8/2085 10/18639 0.8 7.15165467625899 8.8494365362514e-07 4.66491725982395e-05 GO:0032182 ubiquitin-like protein binding 32/2085 120/18639 0.266666666666667 2.38388489208633 1.97153378180839e-06 9.92039952937223e-05 GO:0043024 ribosomal small subunit binding 11/2085 20/18639 0.55 4.91676258992806 2.14354622497223e-06 0.000103169811784533 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 20/2085 58/18639 0.344827586206897 3.08260977424957 2.35387436737187e-06 0.000108572455195027 GO:1990948 ubiquitin ligase inhibitor activity 8/2085 11/18639 0.727272727272727 6.50150425114454 2.92411477718719e-06 0.000129479802333849 GO:0051059 NF-kappaB binding 14/2085 32/18639 0.4375 3.91106115107914 3.05806208094506e-06 0.000130202873984853 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 68/2085 349/18639 0.194842406876791 1.74180701284245 3.29193945598299e-06 0.000134969517695302 GO:0008137 NADH dehydrogenase (ubiquinone) activity 16/2085 41/18639 0.390243902439024 3.48861203719951 3.77317838013694e-06 0.000149175302386128 GO:0031386 protein tag activity 9/2085 15/18639 0.6 5.36374100719424 7.18293092098443e-06 0.000265050150984325 GO:0141047 molecular tag activity 9/2085 15/18639 0.6 5.36374100719424 7.18293092098443e-06 0.000265050150984325 GO:0140104 molecular carrier activity 51/2085 249/18639 0.204819277108434 1.83099592615065 1.31239631250027e-05 0.000468652489657354 GO:0140098 catalytic activity, acting on RNA 71/2085 387/18639 0.183462532299742 1.6400758462997 1.75937927035995e-05 0.000608635266340145 GO:0030515 snoRNA binding 13/2085 32/18639 0.40625 3.63169964028777 1.83902536374711e-05 0.000616909417475167 GO:0043130 ubiquitin binding 26/2085 100/18639 0.26 2.32428776978417 2.82857488575635e-05 0.000920950705450669 GO:0022853 active monoatomic ion transmembrane transporter activity 29/2085 118/18639 0.245762711864407 2.19701255944397 3.17230930407499e-05 0.000983039020305081 GO:0019787 ubiquitin-like protein transferase activity 83/2085 479/18639 0.173277661795407 1.54902750033793 3.19687486278075e-05 0.000983039020305081 GO:0005344 oxygen carrier activity 8/2085 14/18639 0.571428571428571 5.10832476875642 3.89840380447328e-05 0.00113617603068523 GO:0140296 general transcription initiation factor binding 17/2085 53/18639 0.320754716981132 2.8674087145378 3.90015258952474e-05 0.00113617603068523 GO:0002039 p53 binding 20/2085 69/18639 0.289855072463768 2.59117923052862 4.38510980478499e-05 0.00124469655228128 GO:0035925 mRNA 3'-UTR AU-rich region binding 12/2085 30/18639 0.4 3.5758273381295 4.64296419331983e-05 0.00128494034050126 GO:0003697 single-stranded DNA binding 29/2085 121/18639 0.239669421487603 2.14254117367263 5.20809376336694e-05 0.00140618531610907 GO:0016755 aminoacyltransferase activity 84/2085 496/18639 0.169354838709677 1.51395915525644 6.60994536698255e-05 0.00174219274315469 GO:0004601 peroxidase activity 17/2085 57/18639 0.298245614035088 2.66618705035971 0.000108987165771608 0.00280578587230629 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 17/2085 59/18639 0.288135593220339 2.57580782831362 0.000174210028856831 0.00438296595328435 GO:0017069 snRNA binding 16/2085 54/18639 0.296296296296296 2.64876099120703 0.000187565906311462 0.00461412129526195 GO:0001098 basal transcription machinery binding 17/2085 60/18639 0.283333333333333 2.53287769784173 0.000218033079629355 0.00513537487552544 GO:0001099 basal RNA polymerase II transcription machinery binding 17/2085 60/18639 0.283333333333333 2.53287769784173 0.000218033079629355 0.00513537487552544 GO:0051540 metal cluster binding 20/2085 77/18639 0.25974025974026 2.32196580398019 0.000232101153434622 0.00535283285108596 GO:0061631 ubiquitin conjugating enzyme activity 12/2085 35/18639 0.342857142857143 3.06499486125385 0.000262712524220699 0.00593515845535334 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 17/2085 61/18639 0.278688524590164 2.49135511263121 0.000271140135345128 0.00600304259654114 GO:0051020 GTPase binding 56/2085 315/18639 0.177777777777778 1.58925659472422 0.000301098476782168 0.00653560811368352 GO:0016853 isomerase activity 36/2085 180/18639 0.2 1.78791366906475 0.000374436258908239 0.00797117189637347 GO:0016209 antioxidant activity 21/2085 86/18639 0.244186046511628 2.1829178517651 0.000410071236160692 0.00856507280056388 GO:0016251 RNA polymerase II general transcription initiation factor activity 15/2085 53/18639 0.283018867924528 2.53006651282747 0.000510331279782723 0.0104617912355458 GO:0051536 iron-sulfur cluster binding 19/2085 76/18639 0.25 2.23489208633094 0.000554624913451851 0.0111630868943854 GO:0016651 oxidoreductase activity, acting on NAD(P)H 21/2085 88/18639 0.238636363636364 2.1333060824068 0.000570277320594767 0.0112731606053287 GO:0015078 proton transmembrane transporter activity 36/2085 185/18639 0.194594594594595 1.73959167800894 0.000640897802427332 0.0124469099524045 GO:0004842 ubiquitin-protein transferase activity 73/2085 449/18639 0.162583518930958 1.45342647930653 0.000655252147058766 0.0125062780481733 GO:0051082 unfolded protein binding 26/2085 121/18639 0.214876033057851 1.9208989832927 0.000768011601265178 0.0144099803830602 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 27/2085 128/18639 0.2109375 1.88569019784173 0.000829691315773298 0.0153078047760173 GO:0043539 protein serine/threonine kinase activator activity 18/2085 73/18639 0.246575342465753 2.20427712624421 0.000913670285660693 0.0165808689545309 GO:0000287 magnesium ion binding 42/2085 230/18639 0.182608695652174 1.63244291523303 0.000935201285305907 0.01669786811022 GO:0051539 4 iron, 4 sulfur cluster binding 13/2085 45/18639 0.288888888888889 2.58254196642686 0.000959834129748887 0.0168656568513019 GO:0097027 ubiquitin-protein transferase activator activity 7/2085 16/18639 0.4375 3.91106115107914 0.000992924737772173 0.0171744950736531 GO:0050660 flavin adenine dinucleotide binding 20/2085 86/18639 0.232558139534884 2.07896938263343 0.00107829033699535 0.018184006114181 GO:0000175 3'-5'-RNA exonuclease activity 11/2085 35/18639 0.314285714285714 2.80957862281603 0.00108414128594033 0.018184006114181 GO:0003725 double-stranded RNA binding 18/2085 75/18639 0.24 2.1454964028777 0.00127874302632072 0.0211278885095081 GO:0019887 protein kinase regulator activity 45/2085 255/18639 0.176470588235294 1.5775708844689 0.0013067094962957 0.021272461947049 GO:0008408 3'-5' exonuclease activity 15/2085 58/18639 0.258620689655172 2.31195733068717 0.00141900241547318 0.0227657344047653 GO:0004659 prenyltransferase activity 7/2085 17/18639 0.411764705882353 3.68099873042742 0.00152591819881586 0.0241313063727023 GO:0003727 single-stranded RNA binding 20/2085 89/18639 0.224719101123595 2.0088917629941 0.00168554953238949 0.0259190010574216 GO:0019207 kinase regulator activity 49/2085 287/18639 0.170731707317073 1.52626776627479 0.00170014746103493 0.0259190010574216 GO:0070063 RNA polymerase binding 15/2085 59/18639 0.254237288135593 2.2727716132179 0.00170920241842076 0.0259190010574216 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 15/2085 60/18639 0.25 2.23489208633094 0.00204729704929172 0.0306264572103505 GO:0060590 ATPase regulator activity 13/2085 49/18639 0.26530612244898 2.37172221406548 0.00225622847929249 0.0323782409210908 GO:0098641 cadherin binding involved in cell-cell adhesion 7/2085 18/18639 0.388888888888889 3.47649880095923 0.0022577180490986 0.0323782409210908 GO:0061659 ubiquitin-like protein ligase activity 60/2085 372/18639 0.161290322580645 1.44186586214899 0.00227928614630169 0.0323782409210908 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 11/2085 38/18639 0.289473684210526 2.58776978417266 0.00228139366923675 0.0323782409210908 GO:0031072 heat shock protein binding 26/2085 131/18639 0.198473282442748 1.77426547311769 0.00255280398188954 0.0351216891563577 GO:0016790 thiolester hydrolase activity 12/2085 44/18639 0.272727272727273 2.4380640941792 0.002557901479334 0.0351216891563577 GO:0008474 palmitoyl-(protein) hydrolase activity 6/2085 14/18639 0.428571428571429 3.83124357656732 0.00263333351398165 0.0351216891563577 GO:0098599 palmitoyl hydrolase activity 6/2085 14/18639 0.428571428571429 3.83124357656732 0.00263333351398165 0.0351216891563577 GO:0098847 sequence-specific single stranded DNA binding 6/2085 14/18639 0.428571428571429 3.83124357656732 0.00263333351398165 0.0351216891563577 GO:1990757 ubiquitin ligase activator activity 5/2085 10/18639 0.5 4.46978417266187 0.0027056158254507 0.0356561514139753 GO:0015399 primary active transmembrane transporter activity 31/2085 166/18639 0.186746987951807 1.66943746207853 0.00286692872197905 0.0371241369435105 GO:0140223 general transcription initiation factor activity 16/2085 68/18639 0.235294117647059 2.10342784595853 0.00288407929281111 0.0371241369435105 GO:0008301 DNA binding, bending 7/2085 19/18639 0.368421052631579 3.29352517985612 0.00323292063675989 0.0411361281022207 GO:0004532 RNA exonuclease activity 11/2085 40/18639 0.275 2.45838129496403 0.00355452436305406 0.0447143007943278 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 7/2085 20/18639 0.35 3.12884892086331 0.00449915307044067 0.0553295784251556 GO:0017025 TBP-class protein binding 8/2085 25/18639 0.32 2.8606618705036 0.00454292652267203 0.0553295784251556 GO:0004722 protein serine/threonine phosphatase activity 21/2085 103/18639 0.203883495145631 1.82263043933785 0.00454832126168849 0.0553295784251556 GO:0016922 nuclear receptor binding 26/2085 137/18639 0.18978102189781 1.69656041590086 0.00479595314903197 0.0577078275649825 GO:0000993 RNA polymerase II complex binding 10/2085 36/18639 0.277777777777778 2.48321342925659 0.00494726251687412 0.0582619107040388 GO:0005484 SNAP receptor activity 10/2085 36/18639 0.277777777777778 2.48321342925659 0.00494726251687412 0.0582619107040388 GO:0016859 cis-trans isomerase activity 11/2085 42/18639 0.261904761904762 2.34131551901336 0.00534040741835723 0.0615815730429318 GO:0043175 RNA polymerase core enzyme binding 11/2085 42/18639 0.261904761904762 2.34131551901336 0.00534040741835723 0.0615815730429318 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 12/2085 48/18639 0.25 2.23489208633094 0.00554608947826467 0.0632940314684432 GO:0004707 MAP kinase activity 6/2085 16/18639 0.375 3.3523381294964 0.00576730531738575 0.0651470100647554 GO:0008143 poly(A) binding 8/2085 26/18639 0.307692307692308 2.75063641394577 0.0059287544896032 0.0662942547473812 GO:0042393 histone binding 41/2085 247/18639 0.165991902834008 1.48389596015495 0.00634534952557251 0.0702430192480877 GO:0070717 poly-purine tract binding 9/2085 32/18639 0.28125 2.5142535971223 0.00689754738979141 0.0745630352256831 GO:0003684 damaged DNA binding 16/2085 74/18639 0.216216216216216 1.93287964223216 0.00694176235297808 0.0745630352256831 GO:0031491 nucleosome binding 16/2085 74/18639 0.216216216216216 1.93287964223216 0.00694176235297808 0.0745630352256831 GO:0051087 protein-folding chaperone binding 25/2085 134/18639 0.186567164179104 1.66782991517234 0.00700501866618883 0.0745630352256831 GO:0004540 RNA nuclease activity 23/2085 121/18639 0.190082644628099 1.69925679291278 0.00751906899597861 0.0791581023921444 GO:0015631 tubulin binding 59/2085 385/18639 0.153246753246753 1.36995982434831 0.00757972796166875 0.0791581023921444 GO:0005092 GDP-dissociation inhibitor activity 6/2085 17/18639 0.352941176470588 3.15514176893779 0.00808078920024207 0.080829832500035 GO:0048038 quinone binding 6/2085 17/18639 0.352941176470588 3.15514176893779 0.00808078920024207 0.080829832500035 GO:0034062 5'-3' RNA polymerase activity 7/2085 22/18639 0.318181818181818 2.84440810987574 0.00810488835366205 0.080829832500035 GO:0061133 endopeptidase activator activity 7/2085 22/18639 0.318181818181818 2.84440810987574 0.00810488835366205 0.080829832500035 GO:0097747 RNA polymerase activity 7/2085 22/18639 0.318181818181818 2.84440810987574 0.00810488835366205 0.080829832500035 GO:0008080 N-acetyltransferase activity 15/2085 69/18639 0.217391304347826 1.94338442289647 0.00834890723830277 0.0825200027928675 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 10/2085 39/18639 0.256410256410256 2.29219701162147 0.00907413642451179 0.0888944161233146 GO:0016407 acetyltransferase activity 19/2085 96/18639 0.197916666666667 1.76928956834532 0.00932077484226422 0.0896220714753718 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 17/2085 83/18639 0.204819277108434 1.83099592615065 0.00959123392920024 0.0896220714753718 GO:0031267 small GTPase binding 45/2085 283/18639 0.159010600706714 1.42148613264865 0.0096053973108525 0.0896220714753718 GO:0016866 intramolecular transferase activity 8/2085 28/18639 0.285714285714286 2.55416238437821 0.00963417028506706 0.0896220714753718 GO:0046966 nuclear thyroid hormone receptor binding 8/2085 28/18639 0.285714285714286 2.55416238437821 0.00963417028506706 0.0896220714753718 GO:0097718 disordered domain specific binding 8/2085 28/18639 0.285714285714286 2.55416238437821 0.00963417028506706 0.0896220714753718 GO:0003724 RNA helicase activity 16/2085 77/18639 0.207792207792208 1.85757264318415 0.0102441494613137 0.0945022787806193 GO:0015035 protein-disulfide reductase activity 9/2085 34/18639 0.264705882352941 2.36635632670334 0.010513185015703 0.0953942279703545 GO:0019825 oxygen binding 9/2085 34/18639 0.264705882352941 2.36635632670334 0.010513185015703 0.0953942279703545 GO:0004527 exonuclease activity 17/2085 84/18639 0.202380952380952 1.80919835560123 0.0108051749986799 0.0965754248160785 GO:0015036 disulfide oxidoreductase activity 10/2085 40/18639 0.25 2.23489208633094 0.0109140071116644 0.0965754248160785 GO:0070628 proteasome binding 6/2085 18/18639 0.333333333333333 2.97985611510791 0.0109923247758138 0.0965754248160785 GO:1990381 ubiquitin-specific protease binding 6/2085 18/18639 0.333333333333333 2.97985611510791 0.0109923247758138 0.0965754248160785 GO:0106222 lncRNA binding 8/2085 29/18639 0.275862068965517 2.46608781939965 0.0120276791447929 0.104627085155208 GO:0031593 polyubiquitin modification-dependent protein binding 13/2085 59/18639 0.220338983050847 1.96973539812218 0.012097802077567 0.104627085155208 GO:0016860 intramolecular oxidoreductase activity 12/2085 53/18639 0.226415094339623 2.02405321026198 0.0125827307943822 0.107977387514582 GO:0008186 ATP-dependent activity, acting on RNA 16/2085 79/18639 0.20253164556962 1.8105454876605 0.0130613111037751 0.111222087629839 GO:0001091 RNA polymerase II general transcription initiation factor binding 7/2085 24/18639 0.291666666666667 2.60737410071942 0.0134808366665839 0.11391821519014 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 13/2085 60/18639 0.216666666666667 1.93690647482014 0.0139053896638349 0.116615654226252 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 12/2085 54/18639 0.222222222222222 1.98657074340528 0.0145755172915904 0.121143635421664 GO:0004705 JUN kinase activity 5/2085 14/18639 0.357142857142857 3.19270298047276 0.0146641798974734 0.121143635421664 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/2085 36/18639 0.25 2.23489208633094 0.0153914804825827 0.122837499355261 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 9/2085 36/18639 0.25 2.23489208633094 0.0153914804825827 0.122837499355261 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 9/2085 36/18639 0.25 2.23489208633094 0.0153914804825827 0.122837499355261 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 9/2085 36/18639 0.25 2.23489208633094 0.0153914804825827 0.122837499355261 GO:0031492 nucleosomal DNA binding 10/2085 42/18639 0.238095238095238 2.12846865364851 0.0154240401177789 0.122837499355261 GO:0061630 ubiquitin protein ligase activity 53/2085 353/18639 0.15014164305949 1.34220147960951 0.0159094761374982 0.123039857259469 GO:0033192 calmodulin-dependent protein phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0140791 histone H2AXS140 phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:1990439 MAP kinase serine/threonine phosphatase activity 16/2085 81/18639 0.197530864197531 1.76584066080469 0.0164497731476074 0.123039857259469 GO:0005525 GTP binding 56/2085 378/18639 0.148148148148148 1.32438049560352 0.0173307870653621 0.12875960591514 GO:0140597 protein carrier chaperone 31/2085 188/18639 0.164893617021277 1.47407775906934 0.017467183554757 0.128907814634107 GO:0048156 tau protein binding 10/2085 43/18639 0.232558139534884 2.07896938263343 0.0181387461303134 0.131088310831894 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 16/2085 82/18639 0.195121951219512 1.74430601859975 0.0183798033592412 0.131088310831894 GO:0033549 MAP kinase phosphatase activity 16/2085 82/18639 0.195121951219512 1.74430601859975 0.0183798033592412 0.131088310831894 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2085 10/18639 0.4 3.5758273381295 0.0188209683037367 0.131088310831894 GO:0016783 sulfurtransferase activity 4/2085 10/18639 0.4 3.5758273381295 0.0188209683037367 0.131088310831894 GO:0016868 intramolecular phosphotransferase activity 4/2085 10/18639 0.4 3.5758273381295 0.0188209683037367 0.131088310831894 GO:0047429 nucleoside triphosphate diphosphatase activity 4/2085 10/18639 0.4 3.5758273381295 0.0188209683037367 0.131088310831894 GO:0098505 G-rich strand telomeric DNA binding 4/2085 10/18639 0.4 3.5758273381295 0.0188209683037367 0.131088310831894 GO:0061608 nuclear import signal receptor activity 6/2085 20/18639 0.3 2.68187050359712 0.0188912032906796 0.131088310831894 GO:0003714 transcription corepressor activity 33/2085 204/18639 0.161764705882353 1.44610664409649 0.0189468199937697 0.131088310831894 GO:0000774 adenyl-nucleotide exchange factor activity 5/2085 15/18639 0.333333333333333 2.97985611510791 0.0200078135461948 0.135881285862808 GO:0004129 cytochrome-c oxidase activity 5/2085 15/18639 0.333333333333333 2.97985611510791 0.0200078135461948 0.135881285862808 GO:0042809 nuclear vitamin D receptor binding 5/2085 15/18639 0.333333333333333 2.97985611510791 0.0200078135461948 0.135881285862808 GO:0042162 telomeric DNA binding 9/2085 38/18639 0.236842105263158 2.11726618705036 0.0217544368473063 0.146295841108211 GO:0140142 nucleocytoplasmic carrier activity 8/2085 32/18639 0.25 2.23489208633094 0.0218056131733106 0.146295841108211 GO:0016504 peptidase activator activity 12/2085 57/18639 0.210526315789474 1.88201438848921 0.0219982813774769 0.146699382438957 GO:0004860 protein kinase inhibitor activity 16/2085 84/18639 0.19047619047619 1.70277492291881 0.0227546582575067 0.149936944589642 GO:0017018 myosin phosphatase activity 16/2085 84/18639 0.19047619047619 1.70277492291881 0.0227546582575067 0.149936944589642 GO:0019001 guanyl nucleotide binding 58/2085 400/18639 0.145 1.29623741007194 0.0232904842285529 0.151256832931733 GO:0032561 guanyl ribonucleotide binding 58/2085 400/18639 0.145 1.29623741007194 0.0232904842285529 0.151256832931733 GO:0030544 Hsp70 protein binding 11/2085 51/18639 0.215686274509804 1.92814219212865 0.0233648766317312 0.151256832931733 GO:0106310 protein serine kinase activity 53/2085 361/18639 0.146814404432133 1.31245740249905 0.0235496725050956 0.1515667875764 GO:0019783 ubiquitin-like protein peptidase activity 22/2085 127/18639 0.173228346456693 1.54858664249703 0.0245875867239483 0.157332130077519 GO:0001671 ATPase activator activity 7/2085 27/18639 0.259259259259259 2.31766586730615 0.0257117424897195 0.163334230595413 GO:0004518 nuclease activity 33/2085 209/18639 0.157894736842105 1.41151079136691 0.0260876691607034 0.163334230595413 GO:0160215 deacylase activity 13/2085 65/18639 0.2 1.78791366906475 0.0261999298545691 0.163334230595413 GO:0005159 insulin-like growth factor receptor binding 5/2085 16/18639 0.3125 2.79361510791367 0.026480771832017 0.163334230595413 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/2085 16/18639 0.3125 2.79361510791367 0.026480771832017 0.163334230595413 GO:0030275 LRR domain binding 5/2085 16/18639 0.3125 2.79361510791367 0.026480771832017 0.163334230595413 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/2085 11/18639 0.363636363636364 3.25075212557227 0.0270010516702445 0.163334230595413 GO:0032794 GTPase activating protein binding 4/2085 11/18639 0.363636363636364 3.25075212557227 0.0270010516702445 0.163334230595413 GO:0043522 leucine zipper domain binding 4/2085 11/18639 0.363636363636364 3.25075212557227 0.0270010516702445 0.163334230595413 GO:0070990 snRNP binding 4/2085 11/18639 0.363636363636364 3.25075212557227 0.0270010516702445 0.163334230595413 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 21/2085 122/18639 0.172131147540984 1.53877815780163 0.0293959544961452 0.176855008843656 GO:0034212 protein N-acetyltransferase activity 11/2085 53/18639 0.207547169811321 1.85538210940681 0.0304409419019583 0.181813610389321 GO:0000049 tRNA binding 15/2085 80/18639 0.1875 1.6761690647482 0.0305486283038967 0.181813610389321 GO:0016410 N-acyltransferase activity 17/2085 94/18639 0.180851063829787 1.61673044543089 0.030719361356641 0.181852048244928 GO:0004857 enzyme inhibitor activity 59/2085 416/18639 0.141826923076923 1.26787147205313 0.0329784942848826 0.194187197730665 GO:0032183 SUMO binding 5/2085 17/18639 0.294117647058824 2.62928480744816 0.0341474312619232 0.198911403943261 GO:0032977 membrane insertase activity 5/2085 17/18639 0.294117647058824 2.62928480744816 0.0341474312619232 0.198911403943261 GO:0003925 G protein activity 11/2085 54/18639 0.203703703703704 1.82102318145484 0.0344995388953082 0.198911403943261 GO:0050661 NADP binding 11/2085 54/18639 0.203703703703704 1.82102318145484 0.0344995388953082 0.198911403943261 GO:0140101 catalytic activity, acting on a tRNA 23/2085 139/18639 0.165467625899281 1.47920915066508 0.0353788225107793 0.201725694421773 GO:0008017 microtubule binding 41/2085 276/18639 0.148550724637681 1.32797935564592 0.035804902484351 0.201725694421773 GO:0140566 histone reader activity 8/2085 35/18639 0.228571428571429 2.04332990750257 0.036168032037622 0.201725694421773 GO:0030145 manganese ion binding 13/2085 68/18639 0.191176470588235 1.7090351248413 0.0366313132923913 0.201725694421773 GO:1990841 promoter-specific chromatin binding 13/2085 68/18639 0.191176470588235 1.7090351248413 0.0366313132923913 0.201725694421773 GO:0003995 acyl-CoA dehydrogenase activity 4/2085 12/18639 0.333333333333333 2.97985611510791 0.0369921553456367 0.201725694421773 GO:0004859 phospholipase inhibitor activity 4/2085 12/18639 0.333333333333333 2.97985611510791 0.0369921553456367 0.201725694421773 GO:0043047 single-stranded telomeric DNA binding 4/2085 12/18639 0.333333333333333 2.97985611510791 0.0369921553456367 0.201725694421773 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/2085 12/18639 0.333333333333333 2.97985611510791 0.0369921553456367 0.201725694421773 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/2085 12/18639 0.333333333333333 2.97985611510791 0.0369921553456367 0.201725694421773 GO:0097371 MDM2/MDM4 family protein binding 4/2085 12/18639 0.333333333333333 2.97985611510791 0.0369921553456367 0.201725694421773 GO:0019210 kinase inhibitor activity 16/2085 90/18639 0.177777777777778 1.58925659472422 0.0405988485267109 0.220308457446417 GO:0005200 structural constituent of cytoskeleton 19/2085 112/18639 0.169642857142857 1.51653391572456 0.0420433636307226 0.227034163605902 GO:0140713 histone chaperone activity 26/2085 164/18639 0.158536585365854 1.4172486401123 0.042388812483998 0.227788424367892 GO:0003746 translation elongation factor activity 5/2085 18/18639 0.277777777777778 2.48321342925659 0.0430532414488884 0.22978668219879 GO:0042826 histone deacetylase binding 21/2085 127/18639 0.165354330708661 1.47819634056534 0.0431758174321122 0.22978668219879 GO:0097110 scaffold protein binding 13/2085 70/18639 0.185714285714286 1.66020554984584 0.0450482331912769 0.238604756663845 GO:0140030 modification-dependent protein binding 27/2085 173/18639 0.15606936416185 1.39519274753608 0.0463812669963908 0.244495536023832 GO:0004674 protein serine/threonine kinase activity 60/2085 433/18639 0.138568129330254 1.23873926263147 0.047021351067115 0.246694955598561 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/2085 13/18639 0.307692307692308 2.75063641394577 0.0488253581453746 0.250229960495045 GO:0004535 poly(A)-specific ribonuclease activity 4/2085 13/18639 0.307692307692308 2.75063641394577 0.0488253581453746 0.250229960495045 GO:0009982 pseudouridine synthase activity 4/2085 13/18639 0.307692307692308 2.75063641394577 0.0488253581453746 0.250229960495045 GO:0019104 DNA N-glycosylase activity 4/2085 13/18639 0.307692307692308 2.75063641394577 0.0488253581453746 0.250229960495045 GO:0097157 pre-mRNA intronic binding 4/2085 13/18639 0.307692307692308 2.75063641394577 0.0488253581453746 0.250229960495045 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 20/2085 122/18639 0.163934426229508 1.46550300743012 0.0513439122203414 0.261924934690866 GO:0004721 phosphoprotein phosphatase activity 27/2085 175/18639 0.154285714285714 1.37924768756423 0.0522977154825345 0.265566839629201 GO:1990380 K48-linked deubiquitinase activity 5/2085 19/18639 0.263157894736842 2.35251798561151 0.0532245461718457 0.265946483291948 GO:0017056 structural constituent of nuclear pore 6/2085 25/18639 0.24 2.1454964028777 0.0533334410937782 0.265946483291948 GO:0019211 phosphatase activator activity 6/2085 25/18639 0.24 2.1454964028777 0.0533334410937782 0.265946483291948 GO:0047617 fatty acyl-CoA hydrolase activity 6/2085 25/18639 0.24 2.1454964028777 0.0533334410937782 0.265946483291948 GO:0035402 histone H3T11 kinase activity 36/2085 247/18639 0.145748987854251 1.30293303818484 0.0587715115478198 0.291749162705993 GO:0140767 enzyme-substrate adaptor activity 22/2085 139/18639 0.158273381294964 1.41489570933182 0.0590360758059115 0.291754178201536 GO:0031369 translation initiation factor binding 7/2085 32/18639 0.21875 1.95553057553957 0.0597544605113775 0.293991945715977 GO:0036002 pre-mRNA binding 11/2085 59/18639 0.186440677966102 1.66669918302646 0.0605352471735904 0.296515569120197 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 21/2085 132/18639 0.159090909090909 1.42220405493787 0.0611401994279316 0.298159474743261 GO:0016530 metallochaperone activity 4/2085 14/18639 0.285714285714286 2.55416238437821 0.0624898294445351 0.302079655873801 GO:0061665 SUMO ligase activity 4/2085 14/18639 0.285714285714286 2.55416238437821 0.0624898294445351 0.302079655873801 GO:0016289 acyl-CoA hydrolase activity 6/2085 26/18639 0.230769230769231 2.06297731045932 0.0630275890881719 0.303354526611331 GO:0019209 kinase activator activity 23/2085 148/18639 0.155405405405405 1.38925724285437 0.0645739231868003 0.308571448859412 GO:0000339 RNA cap binding 5/2085 20/18639 0.25 2.23489208633094 0.0646689937989011 0.308571448859412 GO:0019003 GDP binding 13/2085 75/18639 0.173333333333333 1.54952517985612 0.0717297676624244 0.34079335966654 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2085 40/18639 0.2 1.78791366906475 0.0720885451265149 0.341034271175436 GO:0061733 protein-lysine-acetyltransferase activity 9/2085 47/18639 0.191489361702128 1.71183223633859 0.0736750181916427 0.347056362289994 GO:0070182 DNA polymerase binding 5/2085 21/18639 0.238095238095238 2.12846865364851 0.0773764243338297 0.357996612426992 GO:0072542 protein phosphatase activator activity 5/2085 21/18639 0.238095238095238 2.12846865364851 0.0773764243338297 0.357996612426992 GO:0140312 cargo adaptor activity 5/2085 21/18639 0.238095238095238 2.12846865364851 0.0773764243338297 0.357996612426992 GO:0016846 carbon-sulfur lyase activity 4/2085 15/18639 0.266666666666667 2.38388489208633 0.0779378352257498 0.357996612426992 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/2085 15/18639 0.266666666666667 2.38388489208633 0.0779378352257498 0.357996612426992 GO:0061578 K63-linked deubiquitinase activity 4/2085 15/18639 0.266666666666667 2.38388489208633 0.0779378352257498 0.357996612426992 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/2085 34/18639 0.205882352941176 1.84049936521371 0.0786844038379741 0.359149512298387 GO:0002020 protease binding 21/2085 136/18639 0.154411764705882 1.38037452391028 0.0788376978215971 0.359149512298387 GO:0016874 ligase activity 25/2085 167/18639 0.149700598802395 1.3382587343299 0.0796256190899593 0.36125229644502 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/2085 41/18639 0.195121951219512 1.74430601859975 0.0811932829148671 0.3650856740153 GO:0140313 molecular sequestering activity 10/2085 55/18639 0.181818181818182 1.62537606278613 0.0819582171655203 0.3650856740153 GO:0035591 signaling adaptor activity 20/2085 129/18639 0.155038759689922 1.38597958842229 0.0820026660366236 0.3650856740153 GO:0140693 molecular condensate scaffold activity 9/2085 48/18639 0.1875 1.6761690647482 0.0821042387160702 0.3650856740153 GO:0019789 SUMO transferase activity 6/2085 28/18639 0.214285714285714 1.91562178828366 0.0853124394504005 0.3650856740153 GO:0051537 2 iron, 2 sulfur cluster binding 6/2085 28/18639 0.214285714285714 1.91562178828366 0.0853124394504005 0.3650856740153 GO:0140097 catalytic activity, acting on DNA 46/2085 336/18639 0.136904761904762 1.22386947584789 0.0861198479376931 0.3650856740153 GO:0004679 AMP-activated protein kinase activity 35/2085 248/18639 0.141129032258065 1.26163262938037 0.0882576123288634 0.3650856740153 GO:0001221 transcription coregulator binding 18/2085 115/18639 0.156521739130435 1.39923678448546 0.0886711948812485 0.3650856740153 GO:0004402 histone acetyltransferase activity 8/2085 42/18639 0.19047619047619 1.70277492291881 0.0909463782715089 0.3650856740153 GO:0051879 Hsp90 protein binding 8/2085 42/18639 0.19047619047619 1.70277492291881 0.0909463782715089 0.3650856740153 GO:0004407 histone deacetylase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0031683 G-protein beta/gamma-subunit complex binding 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0032931 histone H3K56 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0033558 protein lysine deacetylase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0043992 histone H3K9 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0043993 histone H3K18 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0043994 histone H3K23 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0043999 histone H2AK5 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0044012 histone H2AK9 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0044014 histone H2BK5 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0044015 histone H2BK12 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0044016 histone H3K4 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0044017 histone H3K27 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0044018 histone H3K36 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0046972 histone H4K16 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0140517 protein-RNA adaptor activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0140908 histone H3K122 acetyltransferase activity 5/2085 22/18639 0.227272727272727 2.03172007848267 0.0913201259063738 0.3650856740153 GO:0005522 profilin binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0008140 cAMP response element binding protein binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0030957 Tat protein binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0031996 thioesterase binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0033204 ribonuclease P RNA binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0097177 mitochondrial ribosome binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0099122 RNA polymerase II C-terminal domain binding 3/2085 10/18639 0.3 2.68187050359712 0.0920134625567016 0.3650856740153 GO:0051219 phosphoprotein binding 15/2085 93/18639 0.161290322580645 1.44186586214899 0.0926852176578888 0.366437628383153 GO:0030295 protein kinase activator activity 21/2085 139/18639 0.151079136690647 1.35058226799855 0.0941611989544213 0.37094821082756 GO:0043023 ribosomal large subunit binding 4/2085 16/18639 0.25 2.23489208633094 0.0950901896903272 0.371960565325768 GO:0055102 lipase inhibitor activity 4/2085 16/18639 0.25 2.23489208633094 0.0950901896903272 0.371960565325768 GO:0004386 helicase activity 23/2085 155/18639 0.148387096774194 1.32651659317707 0.0966015995136417 0.376542150216906 GO:0008234 cysteine-type peptidase activity 27/2085 187/18639 0.144385026737968 1.29073981456546 0.0994510769306938 0.386288919867642 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 34/2085 243/18639 0.139917695473251 1.25080380140332 0.100347529366835 0.388408094437363 GO:0004712 protein serine/threonine/tyrosine kinase activity 8/2085 43/18639 0.186046511627907 1.66317550610674 0.101342967094978 0.39089430165206 GO:0044013 histone H2B acetyltransferase activity 5/2085 23/18639 0.217391304347826 1.94338442289647 0.106458362296989 0.394438623712116 GO:0048306 calcium-dependent protein binding 13/2085 80/18639 0.1625 1.45267985611511 0.10700943069021 0.394438623712116 GO:0004676 3-phosphoinositide-dependent protein kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0004711 ribosomal protein S6 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0035175 histone H3S10 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0035979 histone H2AXS139 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0044022 histone H3S28 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0044023 histone H4S1 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0044024 histone H2AS1 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0044025 histone H2BS14 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0072354 histone H3T3 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0072371 histone H2AS121 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0072518 Rho-dependent protein serine/threonine kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0140823 histone H2BS36 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0140855 histone H3S57 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0140995 histone H2A kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0140997 histone H4 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0140998 histone H2B kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:1990244 histone H2AT120 kinase activity 34/2085 245/18639 0.138775510204082 1.24059315812656 0.10903181468465 0.394438623712116 GO:0004521 RNA endonuclease activity 12/2085 73/18639 0.164383561643836 1.46951808416281 0.110806117392645 0.399551700174783 GO:0051721 protein phosphatase 2A binding 6/2085 30/18639 0.2 1.78791366906475 0.111372925129255 0.400072638377161 GO:0001046 core promoter sequence-specific DNA binding 8/2085 44/18639 0.181818181818182 1.62537606278613 0.112374123411929 0.400072638377161 GO:0019213 deacetylase activity 7/2085 37/18639 0.189189189189189 1.69126968695314 0.112855801079817 0.400072638377161 GO:0004677 DNA-dependent protein kinase activity 34/2085 246/18639 0.138211382113821 1.23555009650816 0.113550717817712 0.400072638377161 GO:0140857 histone H3T45 kinase activity 34/2085 246/18639 0.138211382113821 1.23555009650816 0.113550717817712 0.400072638377161 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/2085 17/18639 0.235294117647059 2.10342784595853 0.113841807668298 0.400072638377161 GO:0070402 NADPH binding 4/2085 17/18639 0.235294117647059 2.10342784595853 0.113841807668298 0.400072638377161 GO:1990226 histone methyltransferase binding 4/2085 17/18639 0.235294117647059 2.10342784595853 0.113841807668298 0.400072638377161 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/2085 11/18639 0.272727272727273 2.4380640941792 0.116393116639123 0.401393084484452 GO:0005536 D-glucose binding 3/2085 11/18639 0.272727272727273 2.4380640941792 0.116393116639123 0.401393084484452 GO:0008526 phosphatidylinositol transfer activity 3/2085 11/18639 0.272727272727273 2.4380640941792 0.116393116639123 0.401393084484452 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2085 11/18639 0.272727272727273 2.4380640941792 0.116393116639123 0.401393084484452 GO:0034511 U3 snoRNA binding 3/2085 11/18639 0.272727272727273 2.4380640941792 0.116393116639123 0.401393084484452 GO:0048407 platelet-derived growth factor binding 3/2085 11/18639 0.272727272727273 2.4380640941792 0.116393116639123 0.401393084484452 GO:0035403 histone H3T6 kinase activity 34/2085 247/18639 0.137651821862348 1.23054786939679 0.118187761327101 0.406316309904039 GO:0005080 protein kinase C binding 9/2085 52/18639 0.173076923076923 1.54723298284449 0.121346642523678 0.415884623138425 GO:0043998 histone H2A acetyltransferase activity 5/2085 24/18639 0.208333333333333 1.86241007194245 0.122736083696719 0.419348285963789 GO:0016829 lyase activity 28/2085 200/18639 0.14 1.25153956834532 0.125259145209058 0.426651919219777 GO:0003924 GTPase activity 44/2085 331/18639 0.132930513595166 1.18834141146297 0.128446048268458 0.435479171117299 GO:0044183 protein folding chaperone 12/2085 75/18639 0.16 1.4303309352518 0.128637478731126 0.435479171117299 GO:0008525 phosphatidylcholine transporter activity 4/2085 18/18639 0.222222222222222 1.98657074340528 0.134067112302415 0.4497342221781 GO:0035615 clathrin adaptor activity 4/2085 18/18639 0.222222222222222 1.98657074340528 0.134067112302415 0.4497342221781 GO:0070064 proline-rich region binding 4/2085 18/18639 0.222222222222222 1.98657074340528 0.134067112302415 0.4497342221781 GO:0030291 protein serine/threonine kinase inhibitor activity 8/2085 46/18639 0.173913043478261 1.55470753831717 0.13628502906674 0.455793133464897 GO:0019888 protein phosphatase regulator activity 16/2085 107/18639 0.149532710280374 1.3367578834129 0.139594737346911 0.4570697538636 GO:0017124 SH3 domain binding 17/2085 115/18639 0.147826086956522 1.3215014075696 0.141043128696264 0.4570697538636 GO:0101005 deubiquitinase activity 17/2085 115/18639 0.147826086956522 1.3215014075696 0.141043128696264 0.4570697538636 GO:0051117 ATPase binding 13/2085 84/18639 0.154761904761905 1.38350462487153 0.14151286625453 0.4570697538636 GO:0000340 RNA 7-methylguanosine cap binding 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0004032 aldose reductase (NADPH) activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0004526 ribonuclease P activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0016273 arginine N-methyltransferase activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0016274 protein-arginine N-methyltransferase activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0016801 hydrolase activity, acting on ether bonds 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0016803 ether hydrolase activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0016840 carbon-nitrogen lyase activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0034452 dynactin binding 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/2085 12/18639 0.25 2.23489208633094 0.142860103736952 0.4570697538636 GO:0140463 chromatin-protein adaptor activity 9/2085 54/18639 0.166666666666667 1.48992805755396 0.144179319560811 0.459961114564316 GO:0003779 actin binding 57/2085 443/18639 0.128668171557562 1.15023791350667 0.145047903985511 0.461402384229773 GO:0004843 cysteine-type deubiquitinase activity 16/2085 108/18639 0.148148148148148 1.32438049560352 0.147842674822576 0.468945103233788 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 31/2085 229/18639 0.135371179039301 1.21015990700889 0.151560957359832 0.479365656563812 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/2085 40/18639 0.175 1.56442446043165 0.153579891673946 0.482991307054143 GO:0071949 FAD binding 7/2085 40/18639 0.175 1.56442446043165 0.153579891673946 0.482991307054143 GO:0031420 alkali metal ion binding 4/2085 19/18639 0.210526315789474 1.88201438848921 0.155625129937233 0.485287377015541 GO:0120227 acyl-CoA binding 4/2085 19/18639 0.210526315789474 1.88201438848921 0.155625129937233 0.485287377015541 GO:0140036 ubiquitin-modified protein reader activity 4/2085 19/18639 0.210526315789474 1.88201438848921 0.155625129937233 0.485287377015541 GO:0098632 cell-cell adhesion mediator activity 9/2085 55/18639 0.163636363636364 1.46283845650752 0.156353013507715 0.486187600991688 GO:0019208 phosphatase regulator activity 17/2085 117/18639 0.145299145299145 1.29891163991883 0.157265079797988 0.487653902903004 GO:0050681 nuclear androgen receptor binding 5/2085 26/18639 0.192307692307692 1.7191477587161 0.158434162266331 0.488542110386708 GO:0097602 cullin family protein binding 5/2085 26/18639 0.192307692307692 1.7191477587161 0.158434162266331 0.488542110386708 GO:0140658 ATP-dependent chromatin remodeler activity 22/2085 158/18639 0.139240506329114 1.2447500227666 0.165277573110898 0.508228537316013 GO:0016741 transferase activity, transferring one-carbon groups 29/2085 215/18639 0.134883720930233 1.20580224192739 0.16576216099658 0.508306682058763 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2085 13/18639 0.230769230769231 2.06297731045932 0.171070527414425 0.51883581876101 GO:0030955 potassium ion binding 3/2085 13/18639 0.230769230769231 2.06297731045932 0.171070527414425 0.51883581876101 GO:0051011 microtubule minus-end binding 3/2085 13/18639 0.230769230769231 2.06297731045932 0.171070527414425 0.51883581876101 GO:0140666 annealing activity 3/2085 13/18639 0.230769230769231 2.06297731045932 0.171070527414425 0.51883581876101 GO:0000510 H3-H4 histone complex chaperone activity 21/2085 151/18639 0.139072847682119 1.2432512268331 0.173395984697585 0.520003690647138 GO:0140584 chromatin extrusion motor activity 21/2085 151/18639 0.139072847682119 1.2432512268331 0.173395984697585 0.520003690647138 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 21/2085 151/18639 0.139072847682119 1.2432512268331 0.173395984697585 0.520003690647138 GO:0140849 ATP-dependent H2AZ histone chaperone activity 21/2085 151/18639 0.139072847682119 1.2432512268331 0.173395984697585 0.520003690647138 GO:0016831 carboxy-lyase activity 6/2085 34/18639 0.176470588235294 1.5775708844689 0.173804304913677 0.520003690647138 GO:0001222 transcription corepressor binding 8/2085 49/18639 0.163265306122449 1.45952136250184 0.176472998618454 0.526564985096034 GO:0004364 glutathione transferase activity 5/2085 27/18639 0.185185185185185 1.6554756195044 0.177694367430298 0.528784045014355 GO:0016505 peptidase activator activity involved in apoptotic process 4/2085 20/18639 0.2 1.78791366906475 0.178364163971816 0.529354234629492 GO:0051015 actin filament binding 28/2085 209/18639 0.133971291866029 1.19764551994768 0.180095936961892 0.533064711809664 GO:0015616 DNA translocase activity 21/2085 152/18639 0.138157894736842 1.23507194244604 0.181254019437225 0.533638828502682 GO:0140674 ATP-dependent histone chaperone activity 21/2085 152/18639 0.138157894736842 1.23507194244604 0.181254019437225 0.533638828502682 GO:0019903 protein phosphatase binding 20/2085 144/18639 0.138888888888889 1.2416067146283 0.182026002775715 0.534490146081475 GO:0140789 histone phosphatase activity 19/2085 136/18639 0.139705882352941 1.24891028353788 0.182657637909973 0.534866838692085 GO:0031490 chromatin DNA binding 18/2085 128/18639 0.140625 1.25712679856115 0.183120624990334 0.534866838692085 GO:0008094 ATP-dependent activity, acting on DNA 28/2085 210/18639 0.133333333333333 1.19194244604317 0.186882989137437 0.544419655197745 GO:0061775 cohesin loader activity 21/2085 153/18639 0.137254901960784 1.22699957680914 0.189292420167805 0.549991362534805 GO:0036408 histone H3K14 acetyltransferase activity 5/2085 28/18639 0.178571428571429 1.59635149023638 0.197777395252015 0.570799656798111 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2085 43/18639 0.162790697674419 1.4552785678434 0.200060668187382 0.570799656798111 GO:0030983 mismatched DNA binding 3/2085 14/18639 0.214285714285714 1.91562178828366 0.200683445042577 0.570799656798111 GO:0034236 protein kinase A catalytic subunit binding 3/2085 14/18639 0.214285714285714 1.91562178828366 0.200683445042577 0.570799656798111 GO:0044548 S100 protein binding 3/2085 14/18639 0.214285714285714 1.91562178828366 0.200683445042577 0.570799656798111 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/2085 14/18639 0.214285714285714 1.91562178828366 0.200683445042577 0.570799656798111 GO:0071933 Arp2/3 complex binding 3/2085 14/18639 0.214285714285714 1.91562178828366 0.200683445042577 0.570799656798111 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/2085 21/18639 0.19047619047619 1.70277492291881 0.202125985063107 0.570799656798111 GO:0035613 RNA stem-loop binding 4/2085 21/18639 0.19047619047619 1.70277492291881 0.202125985063107 0.570799656798111 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/2085 21/18639 0.19047619047619 1.70277492291881 0.202125985063107 0.570799656798111 GO:0051010 microtubule plus-end binding 4/2085 21/18639 0.19047619047619 1.70277492291881 0.202125985063107 0.570799656798111 GO:0004033 aldo-keto reductase (NADPH) activity 6/2085 36/18639 0.166666666666667 1.48992805755396 0.209400424762105 0.589837837688677 GO:0001223 transcription coactivator binding 7/2085 44/18639 0.159090909090909 1.42220405493787 0.216650014496252 0.608709558495815 GO:0003785 actin monomer binding 5/2085 29/18639 0.172413793103448 1.54130488712478 0.218588991713298 0.609875617486029 GO:0010484 histone H3 acetyltransferase activity 5/2085 29/18639 0.172413793103448 1.54130488712478 0.218588991713298 0.609875617486029 GO:0016791 phosphatase activity 35/2085 273/18639 0.128205128205128 1.14609850581074 0.218717814039705 0.609875617486029 GO:0008649 rRNA methyltransferase activity 4/2085 22/18639 0.181818181818182 1.62537606278613 0.226749509320159 0.629102022098787 GO:0140035 ubiquitin-like protein reader activity 4/2085 22/18639 0.181818181818182 1.62537606278613 0.226749509320159 0.629102022098787 GO:0005523 tropomyosin binding 3/2085 15/18639 0.2 1.78791366906475 0.231369847496784 0.632410916491209 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2085 15/18639 0.2 1.78791366906475 0.231369847496784 0.632410916491209 GO:0050700 CARD domain binding 3/2085 15/18639 0.2 1.78791366906475 0.231369847496784 0.632410916491209 GO:0050780 dopamine receptor binding 3/2085 15/18639 0.2 1.78791366906475 0.231369847496784 0.632410916491209 GO:0141050 histone H3K deacetylase activity 3/2085 15/18639 0.2 1.78791366906475 0.231369847496784 0.632410916491209 GO:0141051 histone H4K deacetylase activity 3/2085 15/18639 0.2 1.78791366906475 0.231369847496784 0.632410916491209 GO:0051018 protein kinase A binding 8/2085 53/18639 0.150943396226415 1.34936880684132 0.23697174357112 0.64182524388485 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 22/2085 167/18639 0.131736526946108 1.17766768621031 0.238383448803791 0.64182524388485 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0008187 poly-pyrimidine tract binding 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0031210 phosphatidylcholine binding 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0031624 ubiquitin conjugating enzyme binding 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0043995 histone H4K5 acetyltransferase activity 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0043996 histone H4K8 acetyltransferase activity 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0043997 histone H4K12 acetyltransferase activity 5/2085 30/18639 0.166666666666667 1.48992805755396 0.240032205030107 0.64182524388485 GO:0003689 DNA clamp loader activity 21/2085 160/18639 0.13125 1.17331834532374 0.250231296273252 0.667484445721663 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/2085 46/18639 0.152173913043478 1.36036909602753 0.251199066943463 0.667573864083291 GO:0004602 glutathione peroxidase activity 4/2085 23/18639 0.173913043478261 1.55470753831717 0.252073961325037 0.667573864083291 GO:0140102 catalytic activity, acting on a rRNA 4/2085 23/18639 0.173913043478261 1.55470753831717 0.252073961325037 0.667573864083291 GO:0051287 NAD binding 8/2085 54/18639 0.148148148148148 1.32438049560352 0.253109556442479 0.668716656281203 GO:0016779 nucleotidyltransferase activity 18/2085 136/18639 0.132352941176471 1.18317816335167 0.259265170017592 0.67976783229717 GO:0005164 tumor necrosis factor receptor binding 5/2085 31/18639 0.161290322580645 1.44186586214899 0.262008846166128 0.67976783229717 GO:0008327 methyl-CpG binding 5/2085 31/18639 0.161290322580645 1.44186586214899 0.262008846166128 0.67976783229717 GO:0000062 fatty-acyl-CoA binding 3/2085 16/18639 0.1875 1.6761690647482 0.262818999298273 0.67976783229717 GO:0003688 DNA replication origin binding 3/2085 16/18639 0.1875 1.6761690647482 0.262818999298273 0.67976783229717 GO:0004708 MAP kinase kinase activity 3/2085 16/18639 0.1875 1.6761690647482 0.262818999298273 0.67976783229717 GO:0008296 3'-5'-DNA exonuclease activity 3/2085 16/18639 0.1875 1.6761690647482 0.262818999298273 0.67976783229717 GO:0017070 U6 snRNA binding 3/2085 16/18639 0.1875 1.6761690647482 0.262818999298273 0.67976783229717 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2085 16/18639 0.1875 1.6761690647482 0.262818999298273 0.67976783229717 GO:0016835 carbon-oxygen lyase activity 11/2085 79/18639 0.139240506329114 1.2447500227666 0.26616452056778 0.68521889364775 GO:0046332 SMAD binding 11/2085 79/18639 0.139240506329114 1.2447500227666 0.26616452056778 0.68521889364775 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2085 39/18639 0.153846153846154 1.37531820697288 0.266906367794325 0.685534452780321 GO:0008168 methyltransferase activity 26/2085 204/18639 0.127450980392157 1.1393567498942 0.268724589632056 0.687877744999999 GO:0043495 protein-membrane adaptor activity 7/2085 47/18639 0.148936170212766 1.33142507270779 0.269061484719964 0.687877744999999 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/2085 24/18639 0.166666666666667 1.48992805755396 0.2779415368507 0.704076158566876 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/2085 24/18639 0.166666666666667 1.48992805755396 0.2779415368507 0.704076158566876 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/2085 24/18639 0.166666666666667 1.48992805755396 0.2779415368507 0.704076158566876 GO:0050699 WW domain binding 4/2085 24/18639 0.166666666666667 1.48992805755396 0.2779415368507 0.704076158566876 GO:0030331 nuclear estrogen receptor binding 6/2085 40/18639 0.15 1.34093525179856 0.286905157697922 0.719039330997827 GO:0061791 GTPase motor activity 6/2085 40/18639 0.15 1.34093525179856 0.286905157697922 0.719039330997827 GO:0140662 ATP-dependent protein folding chaperone 6/2085 40/18639 0.15 1.34093525179856 0.286905157697922 0.719039330997827 GO:1990606 membrane scission GTPase motor activity 6/2085 40/18639 0.15 1.34093525179856 0.286905157697922 0.719039330997827 GO:0016879 ligase activity, forming carbon-nitrogen bonds 7/2085 48/18639 0.145833333333333 1.30368705035971 0.287249294919699 0.719039330997827 GO:0035173 histone kinase activity 44/2085 360/18639 0.122222222222222 1.0926139088729 0.287745640137342 0.719039330997827 GO:0004549 tRNA-specific ribonuclease activity 3/2085 17/18639 0.176470588235294 1.5775708844689 0.294742683218983 0.722577970615853 GO:0016018 cyclosporin A binding 3/2085 17/18639 0.176470588235294 1.5775708844689 0.294742683218983 0.722577970615853 GO:1901567 fatty acid derivative binding 3/2085 17/18639 0.176470588235294 1.5775708844689 0.294742683218983 0.722577970615853 GO:0070279 vitamin B6 binding 8/2085 57/18639 0.140350877192982 1.25467625899281 0.30335598922115 0.722577970615853 GO:0008139 nuclear localization sequence binding 4/2085 25/18639 0.16 1.4303309352518 0.304199592565604 0.722577970615853 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/2085 25/18639 0.16 1.4303309352518 0.304199592565604 0.722577970615853 GO:0016763 pentosyltransferase activity 7/2085 49/18639 0.142857142857143 1.27708119218911 0.305712010969906 0.722577970615853 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2085 33/18639 0.151515151515152 1.35448005232178 0.307171229561054 0.722577970615853 GO:0071889 14-3-3 protein binding 5/2085 33/18639 0.151515151515152 1.35448005232178 0.307171229561054 0.722577970615853 GO:0001094 TFIID-class transcription factor complex binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0008190 eukaryotic initiation factor 4E binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0008239 dipeptidyl-peptidase activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0035374 chondroitin sulfate binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0042975 peroxisome proliferator activated receptor binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0045322 unmethylated CpG binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0050815 phosphoserine residue binding 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0140940 histone H2A methyltransferase activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0141109 transporter activator activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:1990259 histone H2AQ104 methyltransferase activity 2/2085 10/18639 0.2 1.78791366906475 0.310049264717733 0.722577970615853 GO:0035064 methylated histone binding 10/2085 74/18639 0.135135135135135 1.2080497763951 0.312367656889736 0.726451672640625 GO:0032813 tumor necrosis factor receptor superfamily binding 7/2085 50/18639 0.14 1.25153956834532 0.324399179619756 0.750179415304388 GO:0140996 histone H3 kinase activity 43/2085 357/18639 0.120448179271709 1.07675473066925 0.325672238926388 0.750179415304388 GO:0000400 four-way junction DNA binding 3/2085 18/18639 0.166666666666667 1.48992805755396 0.326877797402296 0.750179415304388 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2085 18/18639 0.166666666666667 1.48992805755396 0.326877797402296 0.750179415304388 GO:1901611 phosphatidylglycerol binding 3/2085 18/18639 0.166666666666667 1.48992805755396 0.326877797402296 0.750179415304388 GO:0008307 structural constituent of muscle 6/2085 42/18639 0.142857142857143 1.27708119218911 0.327742054660198 0.750179415304388 GO:0008175 tRNA methyltransferase activity 5/2085 34/18639 0.147058823529412 1.31464240372408 0.33016552691405 0.750179415304388 GO:0004529 DNA exonuclease activity 4/2085 26/18639 0.153846153846154 1.37531820697288 0.330702398074563 0.750179415304388 GO:0005160 transforming growth factor beta receptor binding 4/2085 26/18639 0.153846153846154 1.37531820697288 0.330702398074563 0.750179415304388 GO:0034237 protein kinase A regulatory subunit binding 4/2085 26/18639 0.153846153846154 1.37531820697288 0.330702398074563 0.750179415304388 GO:0052742 phosphatidylinositol kinase activity 4/2085 26/18639 0.153846153846154 1.37531820697288 0.330702398074563 0.750179415304388 GO:0120014 phospholipid transfer activity 4/2085 26/18639 0.153846153846154 1.37531820697288 0.330702398074563 0.750179415304388 GO:0008173 RNA methyltransferase activity 9/2085 67/18639 0.134328358208955 1.20083753892408 0.332744359965856 0.751730625473882 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9/2085 67/18639 0.134328358208955 1.20083753892408 0.332744359965856 0.751730625473882 GO:0045309 protein phosphorylated amino acid binding 8/2085 59/18639 0.135593220338983 1.21214486038288 0.337989239420583 0.762024619223188 GO:0098631 cell adhesion mediator activity 10/2085 76/18639 0.131578947368421 1.17625899280576 0.342936991512339 0.762410654314692 GO:0140034 methylation-dependent protein binding 10/2085 76/18639 0.131578947368421 1.17625899280576 0.342936991512339 0.762410654314692 GO:0005048 signal sequence binding 7/2085 51/18639 0.137254901960784 1.22699957680914 0.34326076452442 0.762410654314692 GO:0016830 carbon-carbon lyase activity 7/2085 51/18639 0.137254901960784 1.22699957680914 0.34326076452442 0.762410654314692 GO:0004519 endonuclease activity 16/2085 127/18639 0.125984251968504 1.12624483090693 0.345899693673455 0.762410654314692 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0008172 S-methyltransferase activity 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0008432 JUN kinase binding 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0010854 adenylate cyclase regulator activity 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0015173 aromatic amino acid transmembrane transporter activity 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0015217 ADP transmembrane transporter activity 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0019206 nucleoside kinase activity 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0032404 mismatch repair complex binding 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0034713 type I transforming growth factor beta receptor binding 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0050786 RAGE receptor binding 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0050998 nitric-oxide synthase binding 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/2085 11/18639 0.181818181818182 1.62537606278613 0.353083964290757 0.762410654314692 GO:0010485 histone H4 acetyltransferase activity 5/2085 35/18639 0.142857142857143 1.27708119218911 0.353312254438516 0.762410654314692 GO:0043015 gamma-tubulin binding 5/2085 35/18639 0.142857142857143 1.27708119218911 0.353312254438516 0.762410654314692 GO:0030159 signaling receptor complex adaptor activity 7/2085 52/18639 0.134615384615385 1.20340343110127 0.36224749802701 0.780171167929766 GO:0141003 histone H2AX kinase activity 42/2085 354/18639 0.11864406779661 1.06062675283502 0.366001992892611 0.786726613848777 GO:0019205 nucleobase-containing compound kinase activity 6/2085 44/18639 0.136363636363636 1.2190320470896 0.369257217494636 0.792185542183259 GO:0008276 protein methyltransferase activity 12/2085 95/18639 0.126315789473684 1.12920863309353 0.373285882812531 0.799279443468998 GO:0019902 phosphatase binding 23/2085 190/18639 0.121052631578947 1.0821582733813 0.376364927197018 0.804316552909457 GO:0005544 calcium-dependent phospholipid binding 7/2085 53/18639 0.132075471698113 1.18069770598615 0.381311199792037 0.813316952157582 GO:0046875 ephrin receptor binding 4/2085 28/18639 0.142857142857143 1.27708119218911 0.383901672878606 0.815698947939764 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2085 28/18639 0.142857142857143 1.27708119218911 0.383901672878606 0.815698947939764 GO:0016004 phospholipase activator activity 3/2085 20/18639 0.15 1.34093525179856 0.390862409360263 0.817584133077534 GO:0030742 GTP-dependent protein binding 3/2085 20/18639 0.15 1.34093525179856 0.390862409360263 0.817584133077534 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0003720 telomerase activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0005049 nuclear export signal receptor activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0005078 MAP-kinase scaffold activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0005095 GTPase inhibitor activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0010853 cyclase activator activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0015368 calcium:monoatomic cation antiporter activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0017166 vinculin binding 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0035259 nuclear glucocorticoid receptor binding 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0036009 protein-glutamine N-methyltransferase activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0070008 serine-type exopeptidase activity 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:1990459 transferrin receptor binding 2/2085 12/18639 0.166666666666667 1.48992805755396 0.395128736401518 0.817584133077534 GO:0004197 cysteine-type endopeptidase activity 11/2085 88/18639 0.125 1.11744604316547 0.396009979384196 0.81787881936251 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2085 29/18639 0.137931034482759 1.23304390969983 0.410351701865055 0.844348204395197 GO:0097472 cyclin-dependent protein kinase activity 4/2085 29/18639 0.137931034482759 1.23304390969983 0.410351701865055 0.844348204395197 GO:0020037 heme binding 17/2085 142/18639 0.119718309859155 1.07023001317256 0.421663504582129 0.862558224067592 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2085 21/18639 0.142857142857143 1.27708119218911 0.422318480076454 0.862558224067592 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2085 21/18639 0.142857142857143 1.27708119218911 0.422318480076454 0.862558224067592 GO:0019200 carbohydrate kinase activity 3/2085 21/18639 0.142857142857143 1.27708119218911 0.422318480076454 0.862558224067592 GO:0140938 histone H3 methyltransferase activity 6/2085 47/18639 0.127659574468085 1.14122149089239 0.431710723408506 0.873898832595992 GO:0003964 RNA-directed DNA polymerase activity 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0005172 vascular endothelial growth factor receptor binding 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0005542 folic acid binding 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0019855 calcium channel inhibitor activity 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0045159 myosin II binding 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0070700 BMP receptor binding 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0140852 histone ubiquitin ligase activity 2/2085 13/18639 0.153846153846154 1.37531820697288 0.43586659258099 0.873898832595992 GO:0046906 tetrapyrrole binding 18/2085 152/18639 0.118421052631579 1.05863309352518 0.436130557672797 0.873898832595992 GO:0016769 transferase activity, transferring nitrogenous groups 4/2085 30/18639 0.133333333333333 1.19194244604317 0.436554701378124 0.873898832595992 GO:0030170 pyridoxal phosphate binding 7/2085 56/18639 0.125 1.11744604316547 0.438504363167866 0.876217202214491 GO:0000217 DNA secondary structure binding 5/2085 39/18639 0.128205128205128 1.14609850581074 0.4457417005861 0.88747493264175 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/2085 39/18639 0.128205128205128 1.14609850581074 0.4457417005861 0.88747493264175 GO:0016881 acid-amino acid ligase activity 3/2085 22/18639 0.136363636363636 1.2190320470896 0.453197791248501 0.897477557982273 GO:0050321 tau-protein kinase activity 3/2085 22/18639 0.136363636363636 1.2190320470896 0.453197791248501 0.897477557982273 GO:0070034 telomerase RNA binding 3/2085 22/18639 0.136363636363636 1.2190320470896 0.453197791248501 0.897477557982273 GO:0016878 acid-thiol ligase activity 4/2085 31/18639 0.129032258064516 1.15349268971919 0.462413346594717 0.910839100854718 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2085 31/18639 0.129032258064516 1.15349268971919 0.462413346594717 0.910839100854718 GO:0072349 modified amino acid transmembrane transporter activity 4/2085 31/18639 0.129032258064516 1.15349268971919 0.462413346594717 0.910839100854718 GO:0004177 aminopeptidase activity 5/2085 40/18639 0.125 1.11744604316547 0.468432635284412 0.917796331433352 GO:0032451 demethylase activity 5/2085 40/18639 0.125 1.11744604316547 0.468432635284412 0.917796331433352 GO:0050997 quaternary ammonium group binding 5/2085 40/18639 0.125 1.11744604316547 0.468432635284412 0.917796331433352 GO:0005347 ATP transmembrane transporter activity 2/2085 14/18639 0.142857142857143 1.27708119218911 0.475063783837392 0.922623874926303 GO:0031404 chloride ion binding 2/2085 14/18639 0.142857142857143 1.27708119218911 0.475063783837392 0.922623874926303 GO:0070742 C2H2 zinc finger domain binding 2/2085 14/18639 0.142857142857143 1.27708119218911 0.475063783837392 0.922623874926303 GO:1901612 cardiolipin binding 2/2085 14/18639 0.142857142857143 1.27708119218911 0.475063783837392 0.922623874926303 GO:1990825 sequence-specific mRNA binding 2/2085 14/18639 0.142857142857143 1.27708119218911 0.475063783837392 0.922623874926303 GO:0042054 histone methyltransferase activity 8/2085 67/18639 0.119402985074627 1.0674111457103 0.478965682091848 0.928572697155299 GO:0005158 insulin receptor binding 3/2085 23/18639 0.130434782608696 1.16603065373788 0.483366365737021 0.928969734150838 GO:0017134 fibroblast growth factor binding 3/2085 23/18639 0.130434782608696 1.16603065373788 0.483366365737021 0.928969734150838 GO:0070577 lysine-acetylated histone binding 3/2085 23/18639 0.130434782608696 1.16603065373788 0.483366365737021 0.928969734150838 GO:0099186 structural constituent of postsynapse 3/2085 23/18639 0.130434782608696 1.16603065373788 0.483366365737021 0.928969734150838 GO:0140103 catalytic activity, acting on a glycoprotein 3/2085 23/18639 0.130434782608696 1.16603065373788 0.483366365737021 0.928969734150838 GO:0008378 galactosyltransferase activity 4/2085 32/18639 0.125 1.11744604316547 0.48784085226496 0.934324954078393 GO:0043425 bHLH transcription factor binding 4/2085 32/18639 0.125 1.11744604316547 0.48784085226496 0.934324954078393 GO:0042169 SH2 domain binding 5/2085 41/18639 0.121951219512195 1.09019126162485 0.49082521017084 0.938417111673781 GO:0001786 phosphatidylserine binding 7/2085 59/18639 0.11864406779661 1.06062675283502 0.494813315349223 0.944410931192397 GO:0005085 guanyl-nucleotide exchange factor activity 26/2085 230/18639 0.11304347826087 1.01055989990616 0.508524570758915 0.952583668108961 GO:0008242 omega peptidase activity 2/2085 15/18639 0.133333333333333 1.19194244604317 0.512555158659024 0.952583668108961 GO:0015116 sulfate transmembrane transporter activity 2/2085 15/18639 0.133333333333333 1.19194244604317 0.512555158659024 0.952583668108961 GO:0120283 protein serine/threonine kinase binding 2/2085 15/18639 0.133333333333333 1.19194244604317 0.512555158659024 0.952583668108961 GO:0004622 lysophospholipase activity 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0005315 phosphate transmembrane transporter activity 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0005540 hyaluronic acid binding 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0060229 lipase activator activity 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0070300 phosphatidic acid binding 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0140033 acetylation-dependent protein binding 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0140612 DNA damage sensor activity 3/2085 24/18639 0.125 1.11744604316547 0.512712769863638 0.952583668108961 GO:0140311 protein sequestering activity 4/2085 33/18639 0.121212121212121 1.08358404185742 0.51276080022412 0.952583668108961 GO:0140416 transcription regulator inhibitor activity 4/2085 33/18639 0.121212121212121 1.08358404185742 0.51276080022412 0.952583668108961 GO:0035198 miRNA binding 5/2085 42/18639 0.119047619047619 1.06423432682425 0.512863474429034 0.952583668108961 GO:0048487 beta-tubulin binding 5/2085 42/18639 0.119047619047619 1.06423432682425 0.512863474429034 0.952583668108961 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2085 52/18639 0.115384615384615 1.03148865522966 0.53268377734714 0.987740270558264 GO:0008200 ion channel inhibitor activity 5/2085 43/18639 0.116279069767442 1.03948469131671 0.534497202069895 0.989445489450459 GO:0030332 cyclin binding 4/2085 34/18639 0.117647058823529 1.05171392297926 0.537106836665463 0.99016371593282 GO:0000030 mannosyltransferase activity 3/2085 25/18639 0.12 1.07274820143885 0.541146384949735 0.99016371593282 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2085 25/18639 0.12 1.07274820143885 0.541146384949735 0.99016371593282 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/2085 25/18639 0.12 1.07274820143885 0.541146384949735 0.99016371593282 GO:0019707 protein-cysteine S-acyltransferase activity 3/2085 25/18639 0.12 1.07274820143885 0.541146384949735 0.99016371593282 GO:0042974 nuclear retinoic acid receptor binding 3/2085 25/18639 0.12 1.07274820143885 0.541146384949735 0.99016371593282 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/2085 25/18639 0.12 1.07274820143885 0.541146384949735 0.99016371593282 GO:0008170 N-methyltransferase activity 11/2085 98/18639 0.112244897959184 1.00342093672001 0.542805054682942 0.991090195418132 GO:0046982 protein heterodimerization activity 41/2085 369/18639 0.111111111111111 0.993285371702638 0.543443314018795 0.991090195418132 GO:0015562 efflux transmembrane transporter activity 2/2085 16/18639 0.125 1.11744604316547 0.548231752853418 0.996539491639956 GO:0022858 alanine transmembrane transporter activity 2/2085 16/18639 0.125 1.11744604316547 0.548231752853418 0.996539491639956 GO:0004864 protein phosphatase inhibitor activity 6/2085 53/18639 0.113207547169811 1.01202660513099 0.552007936183961 1 GO:0016248 channel inhibitor activity 5/2085 44/18639 0.113636363636364 1.01586003924133 0.55568181547698 1 GO:0005154 epidermal growth factor receptor binding 4/2085 35/18639 0.114285714285714 1.02166495375128 0.560822266630231 1 GO:0034061 DNA polymerase activity 4/2085 35/18639 0.114285714285714 1.02166495375128 0.560822266630231 1 GO:0001618 virus receptor activity 9/2085 81/18639 0.111111111111111 0.993285371702638 0.56092818188242 1 GO:0016887 ATP hydrolysis activity 46/2085 417/18639 0.11031175059952 0.98613943377672 0.564036259612683 1 GO:1901682 sulfur compound transmembrane transporter activity 7/2085 63/18639 0.111111111111111 0.993285371702638 0.566829317294 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/2085 26/18639 0.115384615384615 1.03148865522966 0.568595600629105 1 GO:0008198 ferrous iron binding 3/2085 26/18639 0.115384615384615 1.03148865522966 0.568595600629105 1 GO:0030507 spectrin binding 3/2085 26/18639 0.115384615384615 1.03148865522966 0.568595600629105 1 GO:0050750 low-density lipoprotein particle receptor binding 3/2085 26/18639 0.115384615384615 1.03148865522966 0.568595600629105 1 GO:0051139 metal cation:proton antiporter activity 3/2085 26/18639 0.115384615384615 1.03148865522966 0.568595600629105 1 GO:0072341 modified amino acid binding 10/2085 91/18639 0.10989010989011 0.982370147837774 0.573322427477764 1 GO:0140272 exogenous protein binding 9/2085 82/18639 0.109756097560976 0.981172135462362 0.576257667479053 1 GO:0141110 transporter inhibitor activity 5/2085 45/18639 0.111111111111111 0.993285371702638 0.576378254275571 1 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0004550 nucleoside diphosphate kinase activity 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0017110 nucleoside diphosphate phosphatase activity 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0030548 acetylcholine receptor regulator activity 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0031489 myosin V binding 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0051787 misfolded protein binding 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0070403 NAD+ binding 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0070492 oligosaccharide binding 2/2085 17/18639 0.117647058823529 1.05171392297926 0.582030295471342 1 GO:0016409 palmitoyltransferase activity 4/2085 36/18639 0.111111111111111 0.993285371702638 0.583859569975235 1 GO:0052689 carboxylic ester hydrolase activity 10/2085 92/18639 0.108695652173913 0.971692211448233 0.58769213359946 1 GO:0008266 poly(U) RNA binding 3/2085 27/18639 0.111111111111111 0.993285371702638 0.595005989412677 1 GO:0008320 protein transmembrane transporter activity 3/2085 27/18639 0.111111111111111 0.993285371702638 0.595005989412677 1 GO:0023026 MHC class II protein complex binding 3/2085 27/18639 0.111111111111111 0.993285371702638 0.595005989412677 1 GO:0051213 dioxygenase activity 10/2085 93/18639 0.10752688172043 0.961243908099327 0.601838023805953 1 GO:0022829 wide pore channel activity 4/2085 37/18639 0.108108108108108 0.96643982111608 0.606179860008582 1 GO:0042805 actinin binding 4/2085 37/18639 0.108108108108108 0.96643982111608 0.606179860008582 1 GO:0019212 phosphatase inhibitor activity 6/2085 56/18639 0.107142857142857 0.957810894141829 0.607626399063612 1 GO:0015172 acidic amino acid transmembrane transporter activity 2/2085 18/18639 0.111111111111111 0.993285371702638 0.613924357729973 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/2085 18/18639 0.111111111111111 0.993285371702638 0.613924357729973 1 GO:0016854 racemase and epimerase activity 2/2085 18/18639 0.111111111111111 0.993285371702638 0.613924357729973 1 GO:0017075 syntaxin-1 binding 2/2085 18/18639 0.111111111111111 0.993285371702638 0.613924357729973 1 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/2085 18/18639 0.111111111111111 0.993285371702638 0.613924357729973 1 GO:0099602 neurotransmitter receptor regulator activity 2/2085 18/18639 0.111111111111111 0.993285371702638 0.613924357729973 1 GO:0001784 phosphotyrosine residue binding 5/2085 47/18639 0.106382978723404 0.951017909076994 0.616176855171138 1 GO:0019842 vitamin binding 16/2085 150/18639 0.106666666666667 0.953553956834532 0.618891015523375 1 GO:0141052 histone H3 demethylase activity 3/2085 28/18639 0.107142857142857 0.957810894141829 0.620338507396766 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2085 57/18639 0.105263157894737 0.941007194244604 0.625297135951048 1 GO:0017022 myosin binding 8/2085 76/18639 0.105263157894737 0.941007194244604 0.626619393144922 1 GO:0042887 amide transmembrane transporter activity 4/2085 38/18639 0.105263157894737 0.941007194244604 0.627752303089836 1 GO:0003730 mRNA 3'-UTR binding 28/2085 262/18639 0.106870229007634 0.95537371629414 0.631124734593861 1 GO:0042578 phosphoric ester hydrolase activity 39/2085 363/18639 0.107438016528926 0.960449491646352 0.631416204895062 1 GO:0061980 regulatory RNA binding 6/2085 58/18639 0.103448275862069 0.92478293227487 0.642499835977792 1 GO:0003756 protein disulfide isomerase activity 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0008574 plus-end-directed microtubule motor activity 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0042800 histone H3K4 methyltransferase activity 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0046624 sphingolipid transporter activity 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0050145 nucleoside monophosphate kinase activity 2/2085 19/18639 0.105263157894737 0.941007194244604 0.643916908927382 1 GO:0016417 S-acyltransferase activity 3/2085 29/18639 0.103448275862069 0.92478293227487 0.644567754188886 1 GO:0035250 UDP-galactosyltransferase activity 3/2085 29/18639 0.103448275862069 0.92478293227487 0.644567754188886 1 GO:0043236 laminin binding 3/2085 29/18639 0.103448275862069 0.92478293227487 0.644567754188886 1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/2085 29/18639 0.103448275862069 0.92478293227487 0.644567754188886 1 GO:0001968 fibronectin binding 3/2085 30/18639 0.1 0.893956834532374 0.667680315612304 1 GO:0015215 nucleotide transmembrane transporter activity 3/2085 30/18639 0.1 0.893956834532374 0.667680315612304 1 GO:0032452 histone demethylase activity 3/2085 30/18639 0.1 0.893956834532374 0.667680315612304 1 GO:0033612 receptor serine/threonine kinase binding 3/2085 30/18639 0.1 0.893956834532374 0.667680315612304 1 GO:0098918 structural constituent of synapse 3/2085 30/18639 0.1 0.893956834532374 0.667680315612304 1 GO:0004725 protein tyrosine phosphatase activity 10/2085 98/18639 0.102040816326531 0.912200851563647 0.668800312221652 1 GO:0015605 organophosphate ester transmembrane transporter activity 5/2085 50/18639 0.1 0.893956834532374 0.671531801244023 1 GO:0010851 cyclase regulator activity 2/2085 20/18639 0.1 0.893956834532374 0.672034075545951 1 GO:0016408 C-acyltransferase activity 2/2085 20/18639 0.1 0.893956834532374 0.672034075545951 1 GO:0042288 MHC class I protein binding 2/2085 20/18639 0.1 0.893956834532374 0.672034075545951 1 GO:0140939 histone H4 methyltransferase activity 2/2085 20/18639 0.1 0.893956834532374 0.672034075545951 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/2085 60/18639 0.1 0.893956834532374 0.675442359014181 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 28/2085 268/18639 0.104477611940299 0.93398475249651 0.678955101180857 1 GO:0016278 lysine N-methyltransferase activity 7/2085 70/18639 0.1 0.893956834532374 0.67980306506816 1 GO:0016782 transferase activity, transferring sulphur-containing groups 7/2085 70/18639 0.1 0.893956834532374 0.67980306506816 1 GO:0001727 lipid kinase activity 4/2085 41/18639 0.0975609756097561 0.872153009299877 0.687782268639801 1 GO:0004812 aminoacyl-tRNA ligase activity 4/2085 41/18639 0.0975609756097561 0.872153009299877 0.687782268639801 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/2085 41/18639 0.0975609756097561 0.872153009299877 0.687782268639801 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/2085 41/18639 0.0975609756097561 0.872153009299877 0.687782268639801 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/2085 31/18639 0.0967741935483871 0.865119517289394 0.689673205149903 1 GO:0047499 calcium-independent phospholipase A2 activity 3/2085 31/18639 0.0967741935483871 0.865119517289394 0.689673205149903 1 GO:0070325 lipoprotein particle receptor binding 3/2085 31/18639 0.0967741935483871 0.865119517289394 0.689673205149903 1 GO:0140457 protein demethylase activity 3/2085 31/18639 0.0967741935483871 0.865119517289394 0.689673205149903 1 GO:0016836 hydro-lyase activity 6/2085 61/18639 0.0983606557377049 0.879301804458073 0.691160067025793 1 GO:0140299 molecular sensor activity 7/2085 71/18639 0.0985915492957746 0.881365893200932 0.694318158554737 1 GO:0000182 rDNA binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0004090 carbonyl reductase (NADPH) activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0005031 tumor necrosis factor receptor activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0005337 nucleoside transmembrane transporter activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0005345 purine nucleobase transmembrane transporter activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0005381 iron ion transmembrane transporter activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0005528 FK506 binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0031419 cobalamin binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0032356 oxidized DNA binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0035256 G protein-coupled glutamate receptor binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0043121 neurotrophin binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0043295 glutathione binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0043422 protein kinase B binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0051880 G-quadruplex DNA binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0070097 delta-catenin binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0070513 death domain binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0070739 protein-glutamic acid ligase activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0070740 tubulin-glutamic acid ligase activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:1905394 retromer complex binding 1/2085 10/18639 0.1 0.893956834532374 0.694739004806923 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2085 21/18639 0.0952380952380952 0.851387461459404 0.698319927700635 1 GO:0005123 death receptor binding 2/2085 21/18639 0.0952380952380952 0.851387461459404 0.698319927700635 1 GO:0008373 sialyltransferase activity 2/2085 21/18639 0.0952380952380952 0.851387461459404 0.698319927700635 1 GO:0051428 peptide hormone receptor binding 2/2085 21/18639 0.0952380952380952 0.851387461459404 0.698319927700635 1 GO:1904047 S-adenosyl-L-methionine binding 2/2085 21/18639 0.0952380952380952 0.851387461459404 0.698319927700635 1 GO:0022804 active transmembrane transporter activity 48/2085 457/18639 0.105032822757112 0.938948097539474 0.702259899089522 1 GO:0019894 kinesin binding 4/2085 42/18639 0.0952380952380952 0.851387461459404 0.706194773293566 1 GO:0015179 L-amino acid transmembrane transporter activity 6/2085 62/18639 0.0967741935483871 0.865119517289394 0.706365181306027 1 GO:0022884 macromolecule transmembrane transporter activity 3/2085 32/18639 0.09375 0.838084532374101 0.710552414069035 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/2085 32/18639 0.09375 0.838084532374101 0.710552414069035 1 GO:0047498 calcium-dependent phospholipase A2 activity 3/2085 32/18639 0.09375 0.838084532374101 0.710552414069035 1 GO:0061134 peptidase regulator activity 23/2085 226/18639 0.101769911504425 0.909779079391354 0.716554199178281 1 GO:0008238 exopeptidase activity 10/2085 102/18639 0.0980392156862745 0.876428269149386 0.717326118396736 1 GO:0030165 PDZ domain binding 8/2085 83/18639 0.0963855421686747 0.861645141717951 0.723815744110627 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0002162 dystroglycan binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0008199 ferric iron binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0015205 nucleobase transmembrane transporter activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0019107 myristoyltransferase activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0032050 clathrin heavy chain binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0034056 estrogen response element binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0047676 arachidonate-CoA ligase activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0048185 activin binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0180030 inositol phosphate kinase activity 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:1900750 oligopeptide binding 1/2085 11/18639 0.0909090909090909 0.812688031393067 0.72890450885854 1 GO:0005178 integrin binding 16/2085 161/18639 0.0993788819875776 0.888404307609813 0.729249812086905 1 GO:0019956 chemokine binding 3/2085 33/18639 0.0909090909090909 0.812688031393067 0.730331575453526 1 GO:0060589 nucleoside-triphosphatase regulator activity 51/2085 490/18639 0.104081632653061 0.93044486859492 0.730864958746829 1 GO:0004536 DNA nuclease activity 6/2085 64/18639 0.09375 0.838084532374101 0.735221787505513 1 GO:0003678 DNA helicase activity 7/2085 74/18639 0.0945945945945946 0.84563484347657 0.735239764698409 1 GO:0048029 monosaccharide binding 7/2085 74/18639 0.0945945945945946 0.84563484347657 0.735239764698409 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/2085 44/18639 0.0909090909090909 0.812688031393067 0.740617077110715 1 GO:0043014 alpha-tubulin binding 4/2085 44/18639 0.0909090909090909 0.812688031393067 0.740617077110715 1 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0003887 DNA-directed DNA polymerase activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0008171 O-methyltransferase activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0016493 C-C chemokine receptor activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0071617 lysophospholipid acyltransferase activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2085 23/18639 0.0869565217391304 0.777353769158586 0.745638405689546 1 GO:0120013 lipid transfer activity 6/2085 65/18639 0.0923076923076923 0.82519092418373 0.748870929642012 1 GO:0090482 vitamin transmembrane transporter activity 3/2085 34/18639 0.0882352941176471 0.788785442234448 0.749030743723339 1 GO:0001217 DNA-binding transcription repressor activity 28/2085 278/18639 0.100719424460432 0.900388178665701 0.750787608571942 1 GO:0008374 O-acyltransferase activity 5/2085 55/18639 0.0909090909090909 0.812688031393067 0.751403360623884 1 GO:0005506 iron ion binding 15/2085 154/18639 0.0974025974025974 0.870737176492572 0.752710783605979 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/2085 45/18639 0.0888888888888889 0.79462829736211 0.75664037689951 1 GO:0004126 cytidine deaminase activity 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0005165 neurotrophin receptor binding 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0005527 macrolide binding 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0015132 prostaglandin transmembrane transporter activity 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0016423 tRNA (guanine) methyltransferase activity 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0031543 peptidyl-proline dioxygenase activity 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0035497 cAMP response element binding 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0042301 phosphate ion binding 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0097677 STAT family protein binding 1/2085 12/18639 0.0833333333333333 0.744964028776978 0.759247760900087 1 GO:0044325 transmembrane transporter binding 13/2085 136/18639 0.0955882352941176 0.854517562420652 0.765754930060774 1 GO:0004623 phospholipase A2 activity 3/2085 35/18639 0.0857142857142857 0.766248715313464 0.766675288450818 1 GO:0016229 steroid dehydrogenase activity 3/2085 35/18639 0.0857142857142857 0.766248715313464 0.766675288450818 1 GO:0019957 C-C chemokine binding 2/2085 24/18639 0.0833333333333333 0.744964028776978 0.766813463491901 1 GO:0035035 histone acetyltransferase binding 2/2085 24/18639 0.0833333333333333 0.744964028776978 0.766813463491901 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/2085 24/18639 0.0833333333333333 0.744964028776978 0.766813463491901 1 GO:0070840 dynein complex binding 2/2085 24/18639 0.0833333333333333 0.744964028776978 0.766813463491901 1 GO:0030276 clathrin binding 4/2085 46/18639 0.0869565217391304 0.777353769158586 0.771886812927973 1 GO:1990782 protein tyrosine kinase binding 11/2085 117/18639 0.094017094017094 0.84047223759454 0.772010599310878 1 GO:0030695 GTPase regulator activity 50/2085 489/18639 0.102249488752556 0.914066292977888 0.772917643598168 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/2085 36/18639 0.0833333333333333 0.744964028776978 0.783294899221325 1 GO:0005035 death receptor activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0008253 5'-nucleotidase activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0008417 fucosyltransferase activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0031432 titin binding 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0031994 insulin-like growth factor I binding 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0035673 oligopeptide transmembrane transporter activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0043560 insulin receptor substrate binding 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0046974 histone H3K9 methyltransferase activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0046975 histone H3K36 methyltransferase activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0061459 L-arginine transmembrane transporter activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0071714 icosanoid transmembrane transporter activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0071837 HMG box domain binding 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2085 13/18639 0.0769230769230769 0.687659103486442 0.786196191593345 1 GO:0008483 transaminase activity 2/2085 25/18639 0.08 0.715165467625899 0.786436687712959 1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/2085 89/18639 0.0898876404494382 0.80355670519764 0.792328446980138 1 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/2085 89/18639 0.0898876404494382 0.80355670519764 0.792328446980138 1 GO:0016279 protein-lysine N-methyltransferase activity 6/2085 69/18639 0.0869565217391304 0.777353769158586 0.798335115785847 1 GO:0023023 MHC protein complex binding 3/2085 37/18639 0.0810810810810811 0.72482986583706 0.79892269679892 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 12/2085 130/18639 0.0923076923076923 0.82519092418373 0.799535497837487 1 GO:0032266 phosphatidylinositol-3-phosphate binding 4/2085 48/18639 0.0833333333333333 0.744964028776978 0.800111891641914 1 GO:0036121 double-stranded DNA helicase activity 4/2085 48/18639 0.0833333333333333 0.744964028776978 0.800111891641914 1 GO:0140793 histone H2AXY142 phosphatase activity 8/2085 90/18639 0.0888888888888889 0.79462829736211 0.802408207725733 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2085 26/18639 0.0769230769230769 0.687659103486442 0.804590111636614 1 GO:0004950 chemokine receptor activity 2/2085 26/18639 0.0769230769230769 0.687659103486442 0.804590111636614 1 GO:0008157 protein phosphatase 1 binding 2/2085 26/18639 0.0769230769230769 0.687659103486442 0.804590111636614 1 GO:0015216 purine nucleotide transmembrane transporter activity 2/2085 26/18639 0.0769230769230769 0.687659103486442 0.804590111636614 1 GO:0070006 metalloaminopeptidase activity 2/2085 26/18639 0.0769230769230769 0.687659103486442 0.804590111636614 1 GO:0005313 L-glutamate transmembrane transporter activity 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0005545 1-phosphatidylinositol binding 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0008174 mRNA methyltransferase activity 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0008559 ABC-type xenobiotic transporter activity 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0032036 myosin heavy chain binding 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0032454 histone H3K9 demethylase activity 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0042043 neurexin family protein binding 1/2085 14/18639 0.0714285714285714 0.638540596094553 0.810129453728419 1 GO:0005501 retinoid binding 3/2085 38/18639 0.0789473684210526 0.705755395683453 0.813594444831127 1 GO:0019840 isoprenoid binding 3/2085 38/18639 0.0789473684210526 0.705755395683453 0.813594444831127 1 GO:0043531 ADP binding 3/2085 38/18639 0.0789473684210526 0.705755395683453 0.813594444831127 1 GO:0030971 receptor tyrosine kinase binding 7/2085 81/18639 0.0864197530864197 0.772555289102052 0.815337847662058 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/2085 27/18639 0.0740740740740741 0.662190247801759 0.821356841414528 1 GO:0005385 zinc ion transmembrane transporter activity 2/2085 27/18639 0.0740740740740741 0.662190247801759 0.821356841414528 1 GO:0008395 steroid hydroxylase activity 2/2085 27/18639 0.0740740740740741 0.662190247801759 0.821356841414528 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/2085 27/18639 0.0740740740740741 0.662190247801759 0.821356841414528 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/2085 27/18639 0.0740740740740741 0.662190247801759 0.821356841414528 1 GO:0035255 ionotropic glutamate receptor binding 2/2085 27/18639 0.0740740740740741 0.662190247801759 0.821356841414528 1 GO:0003774 cytoskeletal motor activity 14/2085 153/18639 0.0915032679738562 0.817999717872761 0.823197340220743 1 GO:0019905 syntaxin binding 5/2085 61/18639 0.0819672131147541 0.732751503715061 0.826968054092228 1 GO:0061135 endopeptidase regulator activity 17/2085 184/18639 0.0923913043478261 0.825938379730998 0.831038253111285 1 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0004559 alpha-mannosidase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0008020 G protein-coupled photoreceptor activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0008252 nucleotidase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0010181 FMN binding 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0017081 chloride channel regulator activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0031005 filamin binding 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0033130 acetylcholine receptor binding 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0045504 dynein heavy chain binding 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0047372 monoacylglycerol lipase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0048531 beta-1,3-galactosyltransferase activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0051371 muscle alpha-actinin binding 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0140161 monocarboxylate:sodium symporter activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0140776 protein-containing complex destabilizing activity 1/2085 15/18639 0.0666666666666667 0.595971223021583 0.831384760519089 1 GO:0051019 mitogen-activated protein kinase binding 2/2085 28/18639 0.0714285714285714 0.638540596094553 0.836819790185125 1 GO:0051393 alpha-actinin binding 2/2085 28/18639 0.0714285714285714 0.638540596094553 0.836819790185125 1 GO:0015297 antiporter activity 12/2085 135/18639 0.0888888888888889 0.79462829736211 0.838346799029923 1 GO:0005516 calmodulin binding 19/2085 207/18639 0.0917874396135266 0.820540089667397 0.849798475986507 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0005149 interleukin-1 receptor binding 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0005521 lamin binding 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0015923 mannosidase activity 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0070411 I-SMAD binding 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0140328 floppase activity 1/2085 16/18639 0.0625 0.558723021582734 0.850261627696801 1 GO:0004181 metallocarboxypeptidase activity 2/2085 29/18639 0.0689655172413793 0.616521954849913 0.851060681740402 1 GO:0051861 glycolipid binding 2/2085 29/18639 0.0689655172413793 0.616521954849913 0.851060681740402 1 GO:0000149 SNARE binding 9/2085 106/18639 0.0849056603773585 0.759019953848242 0.851612338746434 1 GO:0001530 lipopolysaccharide binding 3/2085 41/18639 0.0731707317073171 0.654114756974908 0.852256697818821 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/2085 41/18639 0.0731707317073171 0.654114756974908 0.852256697818821 1 GO:0140318 protein transporter activity 3/2085 41/18639 0.0731707317073171 0.654114756974908 0.852256697818821 1 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2085 41/18639 0.0731707317073171 0.654114756974908 0.852256697818821 1 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/2085 53/18639 0.0754716981132075 0.67468440342066 0.858391810360759 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7/2085 86/18639 0.0813953488372093 0.7276392839217 0.860018938914159 1 GO:0042056 chemoattractant activity 3/2085 42/18639 0.0714285714285714 0.638540596094553 0.86349223047461 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/2085 17/18639 0.0588235294117647 0.525856961489632 0.867026085960892 1 GO:0009881 photoreceptor activity 1/2085 17/18639 0.0588235294117647 0.525856961489632 0.867026085960892 1 GO:0015278 intracellularly gated calcium channel activity 1/2085 17/18639 0.0588235294117647 0.525856961489632 0.867026085960892 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2085 17/18639 0.0588235294117647 0.525856961489632 0.867026085960892 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2085 17/18639 0.0588235294117647 0.525856961489632 0.867026085960892 1 GO:0046965 nuclear retinoid X receptor binding 1/2085 17/18639 0.0588235294117647 0.525856961489632 0.867026085960892 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/2085 54/18639 0.0740740740740741 0.662190247801759 0.868128320373832 1 GO:0004713 protein tyrosine kinase activity 12/2085 140/18639 0.0857142857142857 0.766248715313464 0.871130053381867 1 GO:0008235 metalloexopeptidase activity 5/2085 66/18639 0.0757575757575758 0.677240026160889 0.874667968309987 1 GO:0005452 solute:inorganic anion antiporter activity 2/2085 31/18639 0.0645161290322581 0.576746344859596 0.876192801677607 1 GO:0016411 acylglycerol O-acyltransferase activity 2/2085 31/18639 0.0645161290322581 0.576746344859596 0.876192801677607 1 GO:0008308 voltage-gated monoatomic anion channel activity 1/2085 18/18639 0.0555555555555556 0.496642685851319 0.881914422915652 1 GO:0008409 5'-3' exonuclease activity 1/2085 18/18639 0.0555555555555556 0.496642685851319 0.881914422915652 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2085 18/18639 0.0555555555555556 0.496642685851319 0.881914422915652 1 GO:0031690 adrenergic receptor binding 1/2085 18/18639 0.0555555555555556 0.496642685851319 0.881914422915652 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/2085 18/18639 0.0555555555555556 0.496642685851319 0.881914422915652 1 GO:0035091 phosphatidylinositol binding 26/2085 284/18639 0.0915492957746479 0.818411186543723 0.885150298314583 1 GO:1902936 phosphatidylinositol bisphosphate binding 9/2085 111/18639 0.0810810810810811 0.72482986583706 0.885650090047978 1 GO:0120015 sterol transfer activity 2/2085 32/18639 0.0625 0.558723021582734 0.887235494184845 1 GO:0003777 microtubule motor activity 5/2085 68/18639 0.0735294117647059 0.65732120186204 0.890356026397362 1 GO:0005548 phospholipid transporter activity 5/2085 68/18639 0.0735294117647059 0.65732120186204 0.890356026397362 1 GO:0046915 transition metal ion transmembrane transporter activity 3/2085 45/18639 0.0666666666666667 0.595971223021583 0.892803792611925 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0005520 insulin-like growth factor binding 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0015245 fatty acid transmembrane transporter activity 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0016918 retinal binding 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0030506 ankyrin binding 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0042834 peptidoglycan binding 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0043395 heparan sulfate proteoglycan binding 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0070003 threonine-type peptidase activity 1/2085 19/18639 0.0526315789473684 0.470503597122302 0.895136507026112 1 GO:0019239 deaminase activity 2/2085 33/18639 0.0606060606060606 0.541792020928712 0.897358327651382 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/2085 46/18639 0.0652173913043478 0.58301532686894 0.901239860961968 1 GO:0017116 single-stranded DNA helicase activity 4/2085 58/18639 0.0689655172413793 0.616521954849913 0.901512614377106 1 GO:0051427 hormone receptor binding 2/2085 34/18639 0.0588235294117647 0.525856961489632 0.906628801646884 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/2085 34/18639 0.0588235294117647 0.525856961489632 0.906628801646884 1 GO:0001972 retinoic acid binding 1/2085 20/18639 0.05 0.446978417266187 0.90687874026191 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2085 20/18639 0.05 0.446978417266187 0.90687874026191 1 GO:0031418 L-ascorbic acid binding 1/2085 20/18639 0.05 0.446978417266187 0.90687874026191 1 GO:0052745 inositol phosphate phosphatase activity 1/2085 20/18639 0.05 0.446978417266187 0.90687874026191 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/2085 20/18639 0.05 0.446978417266187 0.90687874026191 1 GO:0070888 E-box binding 4/2085 59/18639 0.0677966101694915 0.60607243019144 0.90859449463711 1 GO:0061749 forked DNA-dependent helicase activity 3/2085 47/18639 0.0638297872340425 0.570610745446196 0.909071797380205 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/2085 47/18639 0.0638297872340425 0.570610745446196 0.909071797380205 1 GO:0098531 ligand-modulated transcription factor activity 4/2085 60/18639 0.0666666666666667 0.595971223021583 0.915220083405928 1 GO:0009378 four-way junction helicase activity 3/2085 48/18639 0.0625 0.558723021582734 0.916335791096091 1 GO:0038187 pattern recognition receptor activity 3/2085 48/18639 0.0625 0.558723021582734 0.916335791096091 1 GO:0043138 3'-5' DNA helicase activity 3/2085 48/18639 0.0625 0.558723021582734 0.916335791096091 1 GO:0009975 cyclase activity 1/2085 21/18639 0.0476190476190476 0.425693730729702 0.917306680889973 1 GO:0015125 bile acid transmembrane transporter activity 1/2085 21/18639 0.0476190476190476 0.425693730729702 0.917306680889973 1 GO:0015174 basic amino acid transmembrane transporter activity 1/2085 21/18639 0.0476190476190476 0.425693730729702 0.917306680889973 1 GO:0008013 beta-catenin binding 8/2085 106/18639 0.0754716981132075 0.67468440342066 0.917541090935893 1 GO:0070851 growth factor receptor binding 11/2085 139/18639 0.079136690647482 0.707447854665908 0.919412982183252 1 GO:0045505 dynein intermediate chain binding 2/2085 36/18639 0.0555555555555556 0.496642685851319 0.922864711192521 1 GO:0035254 glutamate receptor binding 3/2085 49/18639 0.0612244897959184 0.547320510938188 0.92306674911957 1 GO:0005243 gap junction channel activity 1/2085 22/18639 0.0454545454545455 0.406344015696534 0.926567373249217 1 GO:0008093 cytoskeletal anchor activity 1/2085 22/18639 0.0454545454545455 0.406344015696534 0.926567373249217 1 GO:0008970 phospholipase A1 activity 1/2085 22/18639 0.0454545454545455 0.406344015696534 0.926567373249217 1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/2085 22/18639 0.0454545454545455 0.406344015696534 0.926567373249217 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/2085 22/18639 0.0454545454545455 0.406344015696534 0.926567373249217 1 GO:0140784 metal ion sensor activity 1/2085 22/18639 0.0454545454545455 0.406344015696534 0.926567373249217 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2085 23/18639 0.0434782608695652 0.388676884579293 0.934791417229202 1 GO:0043274 phospholipase binding 1/2085 23/18639 0.0434782608695652 0.388676884579293 0.934791417229202 1 GO:0000146 microfilament motor activity 2/2085 38/18639 0.0526315789473684 0.470503597122302 0.936411149080783 1 GO:0015149 hexose transmembrane transporter activity 1/2085 24/18639 0.0416666666666667 0.372482014388489 0.942094806522129 1 GO:0015295 solute:proton symporter activity 1/2085 24/18639 0.0416666666666667 0.372482014388489 0.942094806522129 1 GO:0055056 D-glucose transmembrane transporter activity 1/2085 24/18639 0.0416666666666667 0.372482014388489 0.942094806522129 1 GO:0038024 cargo receptor activity 4/2085 65/18639 0.0615384615384615 0.550127282789153 0.942314376928367 1 GO:0071855 neuropeptide receptor binding 2/2085 40/18639 0.05 0.446978417266187 0.947679329540916 1 GO:0003707 nuclear steroid receptor activity 1/2085 25/18639 0.04 0.35758273381295 0.94858056147251 1 GO:0004709 MAP kinase kinase kinase activity 1/2085 25/18639 0.04 0.35758273381295 0.94858056147251 1 GO:0005537 D-mannose binding 1/2085 25/18639 0.04 0.35758273381295 0.94858056147251 1 GO:0015645 fatty acid ligase activity 1/2085 25/18639 0.04 0.35758273381295 0.94858056147251 1 GO:0120020 cholesterol transfer activity 1/2085 25/18639 0.04 0.35758273381295 0.94858056147251 1 GO:0120515 fatty acid-CoA ligase activity 1/2085 25/18639 0.04 0.35758273381295 0.94858056147251 1 GO:0035401 histone H3Y41 kinase activity 8/2085 115/18639 0.0695652173913043 0.621883015326869 0.952352803409888 1 GO:0140801 histone H2AXY142 kinase activity 8/2085 115/18639 0.0695652173913043 0.621883015326869 0.952352803409888 1 GO:0017080 sodium channel regulator activity 2/2085 41/18639 0.0487804878048781 0.436076504649939 0.952572797834357 1 GO:0042287 MHC protein binding 2/2085 41/18639 0.0487804878048781 0.436076504649939 0.952572797834357 1 GO:0016757 glycosyltransferase activity 22/2085 267/18639 0.0823970037453183 0.73659364643117 0.954031697060093 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/2085 26/18639 0.0384615384615385 0.343829551743221 0.954340179465946 1 GO:0005112 Notch binding 1/2085 26/18639 0.0384615384615385 0.343829551743221 0.954340179465946 1 GO:0015145 monosaccharide transmembrane transporter activity 1/2085 26/18639 0.0384615384615385 0.343829551743221 0.954340179465946 1 GO:0043548 phosphatidylinositol 3-kinase binding 1/2085 26/18639 0.0384615384615385 0.343829551743221 0.954340179465946 1 GO:0070412 R-SMAD binding 1/2085 26/18639 0.0384615384615385 0.343829551743221 0.954340179465946 1 GO:0015101 organic cation transmembrane transporter activity 5/2085 81/18639 0.0617283950617284 0.551825206501465 0.956570946799173 1 GO:0004520 DNA endonuclease activity 2/2085 42/18639 0.0476190476190476 0.425693730729702 0.957026826202344 1 GO:0170055 lipid transmembrane transporter activity 3/2085 56/18639 0.0535714285714286 0.478905447070915 0.957893951133296 1 GO:0008237 metallopeptidase activity 14/2085 184/18639 0.0760869565217391 0.680184548013763 0.958192206163563 1 GO:0005044 scavenger receptor activity 1/2085 27/18639 0.037037037037037 0.331095123900879 0.959454923237155 1 GO:0015252 proton channel activity 1/2085 27/18639 0.037037037037037 0.331095123900879 0.959454923237155 1 GO:0016405 CoA-ligase activity 1/2085 27/18639 0.037037037037037 0.331095123900879 0.959454923237155 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/2085 27/18639 0.037037037037037 0.331095123900879 0.959454923237155 1 GO:1901981 phosphatidylinositol phosphate binding 14/2085 185/18639 0.0756756756756757 0.676507874781256 0.960319792837037 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 9/2085 130/18639 0.0692307692307692 0.618893193137797 0.961846076134062 1 GO:0045499 chemorepellent activity 1/2085 28/18639 0.0357142857142857 0.319270298047276 0.963996965202045 1 GO:0051119 sugar transmembrane transporter activity 1/2085 28/18639 0.0357142857142857 0.319270298047276 0.963996965202045 1 GO:0051959 dynein light intermediate chain binding 1/2085 28/18639 0.0357142857142857 0.319270298047276 0.963996965202045 1 GO:0004252 serine-type endopeptidase activity 13/2085 176/18639 0.0738636363636364 0.660309025506867 0.96427796785199 1 GO:0004620 phospholipase activity 7/2085 109/18639 0.0642201834862385 0.57410071942446 0.967138250061678 1 GO:0004879 nuclear receptor activity 3/2085 59/18639 0.0508474576271186 0.45455432264358 0.967721987108112 1 GO:0015459 potassium channel regulator activity 3/2085 59/18639 0.0508474576271186 0.45455432264358 0.967721987108112 1 GO:0004629 phospholipase C activity 1/2085 29/18639 0.0344827586206897 0.308260977424957 0.968030403897103 1 GO:0099604 ligand-gated calcium channel activity 1/2085 29/18639 0.0344827586206897 0.308260977424957 0.968030403897103 1 GO:0042626 ATPase-coupled transmembrane transporter activity 6/2085 98/18639 0.0612244897959184 0.547320510938188 0.969453428513942 1 GO:0004180 carboxypeptidase activity 2/2085 46/18639 0.0434782608695652 0.388676884579293 0.971148259341358 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2085 30/18639 0.0333333333333333 0.297985611510791 0.971612166813521 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 13/2085 181/18639 0.0718232044198895 0.64206844469176 0.97291132258077 1 GO:0019838 growth factor binding 9/2085 136/18639 0.0661764705882353 0.591589081675836 0.973850967453052 1 GO:0005543 phospholipid binding 43/2085 497/18639 0.0865191146881288 0.77344353893143 0.973857674014877 1 GO:0005504 fatty acid binding 2/2085 47/18639 0.0425531914893617 0.380407163630798 0.973907213206298 1 GO:0140359 ABC-type transporter activity 2/2085 47/18639 0.0425531914893617 0.380407163630798 0.973907213206298 1 GO:0008236 serine-type peptidase activity 14/2085 194/18639 0.0721649484536082 0.645123488837796 0.975554678662652 1 GO:0005096 GTPase activator activity 21/2085 271/18639 0.0774907749077491 0.692734078419921 0.976301504459654 1 GO:0015171 amino acid transmembrane transporter activity 6/2085 102/18639 0.0588235294117647 0.525856961489632 0.977210898484657 1 GO:0005507 copper ion binding 3/2085 63/18639 0.0476190476190476 0.425693730729702 0.977491581383093 1 GO:0015106 bicarbonate transmembrane transporter activity 1/2085 32/18639 0.03125 0.279361510791367 0.977617241935252 1 GO:0042910 xenobiotic transmembrane transporter activity 1/2085 32/18639 0.03125 0.279361510791367 0.977617241935252 1 GO:0008083 growth factor activity 11/2085 162/18639 0.0679012345679012 0.607007727151612 0.978112395374972 1 GO:0030296 protein tyrosine kinase activator activity 1/2085 33/18639 0.0303030303030303 0.270896010464356 0.980125333006623 1 GO:0017171 serine hydrolase activity 14/2085 198/18639 0.0707070707070707 0.632090691083497 0.980446255876128 1 GO:0016298 lipase activity 8/2085 130/18639 0.0615384615384615 0.550127282789153 0.982290492303279 1 GO:0008376 acetylgalactosaminyltransferase activity 1/2085 34/18639 0.0294117647058824 0.262928480744816 0.982352500623585 1 GO:0015020 glucuronosyltransferase activity 1/2085 34/18639 0.0294117647058824 0.262928480744816 0.982352500623585 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2085 34/18639 0.0294117647058824 0.262928480744816 0.982352500623585 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/2085 34/18639 0.0294117647058824 0.262928480744816 0.982352500623585 1 GO:0016597 amino acid binding 2/2085 51/18639 0.0392156862745098 0.350571307659755 0.982602150299126 1 GO:0005343 organic acid:sodium symporter activity 1/2085 35/18639 0.0285714285714286 0.255416238437821 0.984330196737523 1 GO:0050840 extracellular matrix binding 3/2085 67/18639 0.0447761194029851 0.400279179641362 0.984402728482329 1 GO:0004867 serine-type endopeptidase inhibitor activity 5/2085 95/18639 0.0526315789473684 0.470503597122302 0.985368928961894 1 GO:0005496 steroid binding 6/2085 108/18639 0.0555555555555556 0.496642685851319 0.98548690472911 1 GO:0032934 sterol binding 3/2085 68/18639 0.0441176470588235 0.394392721117224 0.985782282384271 1 GO:0030414 peptidase inhibitor activity 11/2085 169/18639 0.0650887573964497 0.581865395257758 0.985808787564003 1 GO:0005246 calcium channel regulator activity 2/2085 53/18639 0.0377358490566038 0.33734220171033 0.985819318198817 1 GO:0008146 sulfotransferase activity 2/2085 53/18639 0.0377358490566038 0.33734220171033 0.985819318198817 1 GO:0004190 aspartic-type endopeptidase activity 1/2085 36/18639 0.0277777777777778 0.248321342925659 0.986086353467381 1 GO:0015485 cholesterol binding 2/2085 54/18639 0.037037037037037 0.331095123900879 0.987202767234522 1 GO:0004222 metalloendopeptidase activity 6/2085 110/18639 0.0545454545454545 0.48761281883584 0.987550312229617 1 GO:0030280 structural constituent of skin epidermis 1/2085 37/18639 0.027027027027027 0.24160995527902 0.987645776841057 1 GO:0043394 proteoglycan binding 1/2085 37/18639 0.027027027027027 0.24160995527902 0.987645776841057 1 GO:0070001 aspartic-type peptidase activity 1/2085 37/18639 0.027027027027027 0.24160995527902 0.987645776841057 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/2085 70/18639 0.0428571428571429 0.383124357656732 0.988198258120999 1 GO:1901681 sulfur compound binding 20/2085 275/18639 0.0727272727272727 0.650150425114454 0.988729523794104 1 GO:0004866 endopeptidase inhibitor activity 10/2085 161/18639 0.062111801242236 0.555252692256133 0.98892307002971 1 GO:0004175 endopeptidase activity 32/2085 405/18639 0.0790123456790123 0.706336264321876 0.988983596145553 1 GO:0005109 frizzled binding 1/2085 38/18639 0.0263157894736842 0.235251798561151 0.989030496510254 1 GO:0016758 hexosyltransferase activity 13/2085 197/18639 0.065989847715736 0.589920753752328 0.989387332332561 1 GO:0005518 collagen binding 3/2085 72/18639 0.0416666666666667 0.372482014388489 0.990216568928585 1 GO:0015144 carbohydrate transmembrane transporter activity 1/2085 40/18639 0.025 0.223489208633094 0.991351890380506 1 GO:0005319 lipid transporter activity 11/2085 178/18639 0.0617977528089888 0.552445234823377 0.992047370573437 1 GO:0016247 channel regulator activity 10/2085 168/18639 0.0595238095238095 0.532117163412127 0.993082284420099 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/2085 91/18639 0.043956043956044 0.39294805913511 0.993530549173698 1 GO:0005126 cytokine receptor binding 19/2085 275/18639 0.0690909090909091 0.617642903858731 0.993829466462788 1 GO:0008375 acetylglucosaminyltransferase activity 1/2085 43/18639 0.0232558139534884 0.207896938263343 0.993946585703067 1 GO:0141108 transporter regulator activity 10/2085 170/18639 0.0588235294117647 0.525856961489632 0.993968638368424 1 GO:0004497 monooxygenase activity 5/2085 106/18639 0.0471698113207547 0.421677752137912 0.994090574542844 1 GO:0030547 signaling receptor inhibitor activity 1/2085 44/18639 0.0227272727272727 0.203172007848267 0.994625299878648 1 GO:0008201 heparin binding 10/2085 172/18639 0.0581395348837209 0.519742345658357 0.994747287775531 1 GO:0033293 monocarboxylic acid binding 3/2085 79/18639 0.0379746835443038 0.339477278936345 0.994973417850858 1 GO:0042605 peptide antigen binding 1/2085 45/18639 0.0222222222222222 0.198657074340528 0.995227948426807 1 GO:0140303 intramembrane lipid transporter activity 1/2085 45/18639 0.0222222222222222 0.198657074340528 0.995227948426807 1 GO:0008514 organic anion transmembrane transporter activity 18/2085 269/18639 0.0669144981412639 0.598186729426867 0.995456783275805 1 GO:0046943 carboxylic acid transmembrane transporter activity 11/2085 188/18639 0.0585106382978723 0.523059849992347 0.995931478788657 1 GO:0005342 organic acid transmembrane transporter activity 11/2085 189/18639 0.0582010582010582 0.520292337558525 0.996200755931817 1 GO:0005539 glycosaminoglycan binding 15/2085 242/18639 0.0619834710743802 0.554105475949819 0.997207696437562 1 GO:0008081 phosphoric diester hydrolase activity 3/2085 87/18639 0.0344827586206897 0.308260977424957 0.99768895706851 1 GO:0005179 hormone activity 6/2085 132/18639 0.0454545454545455 0.406344015696534 0.997881008109513 1 GO:0099106 ion channel regulator activity 8/2085 160/18639 0.05 0.446978417266187 0.998048114802469 1 GO:0005003 ephrin receptor activity 1/2085 53/18639 0.0188679245283019 0.168671100855165 0.998157506191918 1 GO:0005005 transmembrane-ephrin receptor activity 1/2085 53/18639 0.0188679245283019 0.168671100855165 0.998157506191918 1 GO:0043178 alcohol binding 3/2085 92/18639 0.0326086956521739 0.29150766343447 0.998588653532164 1 GO:0042562 hormone binding 3/2085 94/18639 0.0319148936170213 0.285305372723098 0.998843011680955 1 GO:0015370 solute:sodium symporter activity 2/2085 79/18639 0.0253164556962025 0.226318185957563 0.999083435593471 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/2085 60/18639 0.0166666666666667 0.148992805755396 0.999199033524739 1 GO:0042277 peptide binding 14/2085 249/18639 0.0562248995983936 0.502626332668805 0.999212426981058 1 GO:0015291 secondary active transmembrane transporter activity 17/2085 287/18639 0.0592334494773519 0.529521469932068 0.999274089147544 1 GO:0008194 UDP-glycosyltransferase activity 6/2085 145/18639 0.0413793103448276 0.369913172909948 0.999299746865534 1 GO:0015294 solute:monoatomic cation symporter activity 4/2085 116/18639 0.0344827586206897 0.308260977424957 0.999354752268196 1 GO:0001540 amyloid-beta binding 2/2085 83/18639 0.0240963855421687 0.215411285429488 0.999404646461443 1 GO:0005254 chloride channel activity 2/2085 83/18639 0.0240963855421687 0.215411285429488 0.999404646461443 1 GO:0030246 carbohydrate binding 16/2085 280/18639 0.0571428571428571 0.510832476875642 0.999485756483791 1 GO:0005253 monoatomic anion channel activity 3/2085 103/18639 0.029126213592233 0.260375777048264 0.999531304149636 1 GO:0015103 inorganic anion transmembrane transporter activity 7/2085 165/18639 0.0424242424242424 0.379254414650098 0.99957166824902 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 33/2085 484/18639 0.0681818181818182 0.609516023544801 0.999613550699406 1 GO:0033218 amide binding 13/2085 247/18639 0.0526315789473684 0.470503597122302 0.999627221533963 1 GO:0001216 DNA-binding transcription activator activity 33/2085 491/18639 0.0672097759674134 0.600826385734589 0.999736240849659 1 GO:0031406 carboxylic acid binding 8/2085 187/18639 0.0427807486631016 0.382441426537914 0.99977934169593 1 GO:0019955 cytokine binding 5/2085 144/18639 0.0347222222222222 0.310401678657074 0.999799359074047 1 GO:0043177 organic acid binding 8/2085 189/18639 0.0423280423280423 0.378394427315291 0.999813356899509 1 GO:0015293 symporter activity 5/2085 146/18639 0.0342465753424658 0.306149600867251 0.99983348810643 1 GO:0004896 cytokine receptor activity 2/2085 96/18639 0.0208333333333333 0.186241007194245 0.999855464366829 1 GO:0019199 transmembrane receptor protein kinase activity 1/2085 78/18639 0.0128205128205128 0.114609850581074 0.99990610818446 1 GO:0005201 extracellular matrix structural constituent 6/2085 168/18639 0.0357142857142857 0.319270298047276 0.999909453915354 1 GO:0015108 chloride transmembrane transporter activity 3/2085 121/18639 0.0247933884297521 0.221642190379927 0.999926031031039 1 GO:0008509 monoatomic anion transmembrane transporter activity 4/2085 149/18639 0.0268456375838926 0.239988411955 0.999974492067461 1 GO:0030527 structural constituent of chromatin 1/2085 98/18639 0.0102040816326531 0.0912200851563647 0.999991348867175 1 GO:0001664 G protein-coupled receptor binding 13/2085 297/18639 0.0437710437710438 0.391294237337403 0.999991882984079 1 GO:0015085 calcium ion transmembrane transporter activity 3/2085 147/18639 0.0204081632653061 0.182440170312729 0.999995211600521 1 GO:0005262 calcium channel activity 2/2085 131/18639 0.0152671755725191 0.136481959470591 0.999997034695564 1 GO:0099094 ligand-gated monoatomic cation channel activity 2/2085 136/18639 0.0147058823529412 0.131464240372408 0.999998309595966 1 GO:0005267 potassium channel activity 1/2085 124/18639 0.00806451612903226 0.0720932931074495 0.999999611781031 1 GO:0003823 antigen binding 3/2085 174/18639 0.0172413793103448 0.154130488712478 0.999999738552906 1 GO:0001653 peptide receptor activity 1/2085 128/18639 0.0078125 0.0698403776978417 0.999999759278835 1 GO:0140375 immune receptor activity 2/2085 156/18639 0.0128205128205128 0.114609850581074 0.999999823795437 1 GO:0015081 sodium ion transmembrane transporter activity 2/2085 164/18639 0.0121951219512195 0.109019126162485 0.999999929044796 1 GO:0005125 cytokine activity 5/2085 234/18639 0.0213675213675214 0.191016417635123 0.999999972832706 1 GO:0015276 ligand-gated monoatomic ion channel activity 2/2085 186/18639 0.010752688172043 0.0961243908099327 0.999999994258244 1 GO:0015079 potassium ion transmembrane transporter activity 1/2085 160/18639 0.00625 0.0558723021582734 0.999999994760409 1 GO:0022834 ligand-gated channel activity 2/2085 188/18639 0.0106382978723404 0.0951017909076994 0.999999995435348 1 GO:0005244 voltage-gated monoatomic ion channel activity 1/2085 173/18639 0.00578034682080925 0.0516738054642991 0.999999998895545 1 GO:0022832 voltage-gated channel activity 1/2085 175/18639 0.00571428571428571 0.0510832476875642 0.999999999130879 1 GO:0045182 translation regulator activity 10/2085 356/18639 0.0280898876404494 0.251111470374262 0.999999999200063 1 GO:0030371 translation repressor activity 5/2085 329/18639 0.0151975683890578 0.135859701296713 0.999999999998886 1 GO:0005261 monoatomic cation channel activity 4/2085 341/18639 0.0117302052785924 0.104862971792654 0.999999999999973 1 GO:0022836 gated channel activity 3/2085 318/18639 0.00943396226415094 0.0843355504275825 0.999999999999974 1 GO:0046873 metal ion transmembrane transporter activity 9/2085 450/18639 0.02 0.178791366906475 0.999999999999988 1 GO:0005216 monoatomic ion channel activity 7/2085 448/18639 0.015625 0.139680755395683 1 1