category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	113/1237	222/9376	3.85809900442075	RPL22L1/MRPS15/MRPL11/MRPL51/RPS26/RPL29/RPL36/RPSA/RPL22/RPL38/RPL5/RPL14/RPL35/RPS5/RPL35A/RPL24/RPL6/RPS7/RPL19/RPL27/RPL21/RPL7A/RPL36AL/RPL23A/RPS27/RPL32/RPS3A/RPL37/RPL39/RPL7/RPS13/RPL37A/RPS23/RPS4X/RPS15/RPL18/RPL15/RPL12/RPLP0/RPS6/RPS3/RPL18A/RPS19/RPS27A/RPS24/RPL3/RPL8/RPLP2/RPS14/RPL11/RPL28/RPS2/RPS18/RPL13/RPL30/RPL10/MRPL23/MRPS6/RPS9/RPS25/UBA52/RPL4/MRPL13/RPS29/RPL23/MRPL20/MRPS33/MRPL40/MRPS16/MRPL16/MRPL22/MRPS7/MRPL41/MRPL14/MRPL37/MRPL27/MRPS21/MRPS12/RPL26L1/MRPS18C/MRPL52/MRPL17/MRPL47/MRPL21/DAP3/MRPS9/MRPL12/MRPL35/MRPL42/MRPL9/MRPS31/MRPL39/MRPL24/MRPS23/RSL24D1/MRPS14/MRPS26/MRPL3/MRPL4/MRPS5/MRPS22/MRPS34/MRPL50/MRPL49/MRPL15/MRPS28/MRPL54/MRPL18/MRPL32/MRPL19/MRPL44/MRPS30/MRPL45	16.8009278045228
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	100/1237	268/9376	2.82821945245478	NDUFV3/CALM3/HSPA5/TUBB/TUBA1B/TUBB6/TUBA1C/NDUFA4/PSMB2/TUBB4B/UQCRH/CALM1/TXN2/COX5B/PSMA7/COX6C/PSMA4/MT-CO3/PSMB1/COX5A/RPS27A/MT-CO1/MT-CO2/PARK7/NDUFV2/UBE2L3/PSMB6/NDUFC1/NDUFS5/SLC39A10/COX7C/UBA52/COX8C/PSMB3/VDAC1/PSMB5/NDUFA6/PSMA1/VDAC2/COX6B1/NDUFB2/PSMD11/PSMA3/NDUFB11/NDUFB4/NDUFC2/SLC25A6/PSMD4/GNAI1/NDUFS8/SLC25A5/ADRM1/NDUFS2/PSMC3/NDUFA3/PSMB4/PSMD3/NDUFAB1/COX7B/PSMD2/NDUFB3/COX7A1/PSMD7/PSMD12/NDUFA4L2/VDAC3/EIF2S1/PSMD14/MAOB/NDUFS4/NDUFB7/PSMC4/UQCRFS1/NDUFS3/NDUFA12/TRAP1/NDUFA9/PSMD13/NDUFB9/GNAI3/PSMB7/MT-ND6/NDUFS7/PSMD6/ADCY5/PSMC5/TP53/NDUFV1/UQCRC1/SLC39A4/CYC1/SNCA/PSMC1/PSMC6/SLC25A4/UBA1/NDUFA8/KEAP1/PSMD1/PSMC2	11.8377503125847
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	66/1237	158/9376	3.16617377690001	CCNB1/PTTG1/CDC20/CCNE1/CCNB2/SKP2/CDK7/MAD2L1/YWHAE/CDK1/ANAPC11/CHEK1/MCM7/CCNA2/SMC1A/RAD21/WEE1/AURKB/CDT1/ORC6/CCND3/CDC6/YWHAQ/MYC/TGFB1/PKMYT1/CDC45/PLK1/MCM6/NDC80/SFN/MCM5/TRIP13/PRKDC/CDCA5/PPP2R1A/BUB3/DBF4/FBXO5/CDK2/CCND2/BUB1/BUB1B/TTK/TP53/TFDP1/CDC25C/PPP2R1B/E2F1/ORC1/CHEK2/CDC25A/CDKN2C/ESCO2/TICRR/HDAC8/PCNA/TFDP2/CUL1/PDS5B/E2F3/CDKN1B/ESPL1/E2F5/CCNE2/ANAPC1	10.7050438215776
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	90/1237	275/9376	2.48060557066216	CYBA/NDUFV3/CAV1/HSPA5/TUBB/TUBA1B/TUBB6/TUBA1C/NDUFA4/PSMB2/TUBB4B/UQCRH/COX5B/PSMA7/COX6C/PSMA4/MT-CO3/PSMB1/COX5A/MT-CO1/MT-CO2/NDUFV2/PSMB6/NDUFC1/NDUFS5/COX7C/COX8C/PSMB3/VDAC1/PSMB5/NDUFA6/PSMA1/VDAC2/COX6B1/NDUFB2/PSMD11/PSMA3/NDUFB11/NDUFB4/NDUFC2/SLC25A6/PSMD4/NDUFS8/SLC25A5/ADRM1/NDUFS2/PSMC3/NDUFA3/PSMB4/PSMD3/NDUFAB1/COX7B/PSMD2/NDUFB3/COX7A1/PSMD7/PSMD12/NDUFA4L2/VDAC3/EIF2S1/PSMD14/NDUFS4/NDUFB7/PSMC4/UQCRFS1/STIP1/NDUFS3/NDUFA12/MAPK12/NDUFA9/PSMD13/NDUFB9/CREB3L1/PSMB7/MT-ND6/NDUFS7/PSMD6/FYN/PSMC5/NDUFV1/UQCRC1/CYC1/PSMC1/PSMC6/SLC25A4/NDUFA8/PSMD1/PSMC2/PRKCD/CSNK2A1	9.71507443780646
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	96/1237	308/9376	2.36248149586872	NDUFV3/TUBB/TUBA1B/TUBB6/TUBA1C/NDUFA4/PSMB2/TUBB4B/UQCRH/COX5B/PSMA7/COX6C/PSMA4/MT-CO3/PSMB1/COX5A/MT-CO1/MT-CO2/NDUFV2/PSMB6/NDUFC1/NDUFS5/COX7C/COX8C/PSMB3/VDAC1/PSMB5/NDUFA6/PSMA1/VDAC2/COX6B1/NDUFB2/PSMD11/TGM2/PSMA3/NDUFB11/NDUFB4/POLR2I/NDUFC2/SLC25A6/PSMD4/POLR2H/NDUFS8/SLC25A5/SLC1A2/ADRM1/NDUFS2/PSMC3/NDUFA3/PSMB4/PSMD3/NDUFAB1/COX7B/PSMD2/NDUFB3/COX7A1/PPARG/PSMD7/PSMD12/POLR2F/NDUFA4L2/VDAC3/IFT57/PSMD14/NDUFS4/NDUFB7/PSMC4/UQCRFS1/NDUFS3/POLR2L/NDUFA12/NDUFA9/TFAM/PSMD13/NDUFB9/CREB3L1/PSMB7/MT-ND6/NDUFS7/PSMD6/PLCB3/PSMC5/TP53/NDUFV1/UQCRC1/POLR2E/CYC1/PSMC1/PSMC6/SLC25A4/NDUFA8/PSMD1/PSMC2/POLR2G/NRBF2/DCTN5	9.47840319823143
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	29/1237	46/9376	4.77846121401708	PSMB2/PSMA7/PSMA4/PSMB1/POMP/PSMB6/PSMB3/PSMB5/PSMA1/PSMD11/PSMA3/PSMD4/ADRM1/PSMC3/PSMB4/PSMD3/PSMD2/PSMD7/PSMD12/PSMD14/PSMC4/PSMD13/PSMB7/PSMD6/PSMC5/PSMC1/PSMC6/PSMD1/PSMC2	10.0147018946281
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	105/1237	388/9376	2.05118802556901	NDUFV3/CALM3/TUBB/TUBA1B/TUBB6/HSD17B10/DKK1/TUBA1C/NDUFA4/PSMB2/TUBB4B/UQCRH/CALM1/COX5B/PSMA7/COX6C/GAPDH/PSMA4/MT-CO3/PSMB1/COX5A/MT-CO1/MT-CO2/NDUFV2/PSMB6/NDUFC1/NDUFS5/SLC39A10/COX7C/APP/COX8C/PSMB3/VDAC1/PSMB5/NDUFA6/PSMA1/VDAC2/COX6B1/NDUFB2/PSMD11/PSMA3/NDUFB11/NDUFB4/NDUFC2/WNT10B/SLC25A6/PSMD4/NDUFS8/SLC25A5/ADRM1/NDUFS2/PSMC3/CTNNB1/NDUFA3/PSMB4/PSMD3/NDUFAB1/COX7B/PSMD2/NDUFB3/COX7A1/PSMD7/PSMD12/NDUFA4L2/VDAC3/WNT3A/CSNK1E/AKT1/EIF2S1/PSMD14/NDUFS4/NDUFB7/PSMC4/UQCRFS1/NDUFS3/WNT2/NDUFA12/HRAS/NDUFA9/PSMD13/NDUFB9/PSMB7/MT-ND6/NDUFS7/CAPN1/PSMD6/PLCB3/PSMC5/NDUFV1/UQCRC1/SLC39A4/MAP2K2/CYC1/SNCA/PSMC1/PSMC6/LRP6/SLC25A4/NDUFA8/PSMD1/AXIN1/PSMC2/NRBF2/NAE1/CSNK2A1	8.24422241428756
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	68/1237	205/9376	2.51421811227005	COL1A1/COL3A1/CYBA/COL1A2/MMP2/NDUFV3/NDUFA4/UQCRH/COX5B/COX6C/GAPDH/MT-CO3/COX5A/MT-CO1/MT-CO2/NDUFV2/NDUFC1/NDUFS5/COX7C/PPP1CA/SLC2A1/COX8C/VDAC1/NDUFA6/VDAC2/COX6B1/NDUFB2/NDUFB11/NDUFB4/REN/NDUFC2/SLC25A6/PTEN/PARP1/TGFB1/NDUFS8/SLC25A5/NDUFS2/NDUFA3/NDUFAB1/COX7B/NDUFB3/COX7A1/NDUFA4L2/PDHA1/VDAC3/AKT1/GYS1/NDUFS4/NDUFB7/UQCRFS1/NDUFS3/NDUFA12/MAPK12/NDUFA9/PRKCZ/NDUFB9/MT-ND6/NDUFS7/PLCB3/NDUFV1/UQCRC1/PPP1CB/CYC1/SLC25A4/NDUFA8/PDHB/PRKCD	8.54558865883451
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	100/1237	368/9376	2.05968155776598	NDUFV3/HSPA5/TUBB/TUBA1B/TUBB6/TUBA1C/NDUFA4/PSMB2/TUBB4B/UQCRH/COX5B/PSMA7/HNRNPA3/COX6C/PFN1/ACTG1/PSMA4/MT-CO3/PSMB1/COX5A/HNRNPA2B1/MT-CO1/MT-CO2/ACTB/HNRNPA1/NDUFV2/ALYREF/PSMB6/NDUFC1/NDUFS5/COX7C/COX8C/PSMB3/VDAC1/PSMB5/NDUFA6/PSMA1/NUP37/COX6B1/NDUFB2/PSMD11/PSMA3/NDUFB11/NDUFB4/NDUFC2/PSMD4/SRSF3/VCP/SRSF7/NDUFS8/SLC1A2/ADRM1/NDUFS2/PSMC3/NDUFA3/PSMB4/PSMD3/NDUFAB1/COX7B/PSMD2/NDUFB3/COX7A1/PSMD7/PSMD12/NDUFA4L2/TOMM40/EIF2S1/PSMD14/NDUFS4/NDUFB7/PSMC4/UQCRFS1/NDUFS3/NDUFA12/MAPK12/NDUFA9/PSMD13/NDUFB9/PSMB7/MT-ND6/NDUFS7/PSMD6/PSMC5/TP53/NDUFV1/UQCRC1/CYC1/PSMC1/MAP2K6/PSMC6/NDUFA8/PSMD1/VAPB/PSMC2/NRBF2/MAP1LC3A/NRG4/NDC1/DERL1/DCTN5	8.08481451286803
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	116/1237	480/9376	1.83174346537321	NDUFV3/CALM3/HSPA5/TUBB/TUBA1B/TUBB6/HSD17B10/DKK1/TUBA1C/NDUFA4/PSMB2/TUBB4B/UQCRH/CALM1/COX5B/PSMA7/COX6C/PSMA4/MT-CO3/PSMB1/COX5A/RPS27A/MT-CO1/MT-CO2/PARK7/NDUFV2/UBE2L3/PSMB6/NDUFC1/NDUFS5/COX7C/UBA52/APP/COX8C/PSMB3/VDAC1/PSMB5/NDUFA6/PSMA1/VDAC2/COX6B1/NDUFB2/PSMD11/PSMA3/NDUFB11/NDUFB4/NDUFC2/WNT10B/SLC25A6/PSMD4/VCP/NDUFS8/SLC25A5/ADRM1/NDUFS2/PSMC3/CTNNB1/NDUFA3/PSMB4/PSMD3/NDUFAB1/COX7B/PSMD2/NDUFB3/COX7A1/PSMD7/PSMD12/NDUFA4L2/VDAC3/TOMM40/WNT3A/IFT57/CSNK1E/EIF2S1/PSMD14/NDUFS4/NDUFB7/PSMC4/UQCRFS1/NDUFS3/WNT2/NDUFA12/TRAP1/MAPK12/HRAS/NDUFA9/PSMD13/NDUFB9/PSMB7/MT-ND6/NDUFS7/CAPN1/PSMD6/PLCB3/PSMC5/NDUFV1/UQCRC1/MAP2K2/CYC1/SNCA/PSMC1/MAP2K6/PSMC6/LRP6/SLC25A4/UBA1/NDUFA8/PSMD1/VAPB/AXIN1/PSMC2/NRBF2/MAP1LC3A/DERL1/CSNK2A1/DCTN5	7.29285523583788
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	66/1237	235/9376	2.12874662446895	NDUFV3/NDUFA4/GRB2/UQCRH/COX5B/COX6C/ACTG1/MT-CO3/RPS6/COX5A/MT-CO1/MT-CO2/ACTB/NDUFV2/NDUFC1/NDUFS5/COX7C/COX8C/NDUFA6/COX6B1/SMARCA2/NDUFB2/NDUFB11/NDUFB4/COX20/CPT1C/NDUFC2/NDUFAF2/KDM1A/NDUFS8/NDUFS2/NDUFA3/NDUFAB1/COX7B/NDUFB3/COX7A1/PPARG/COA6/NDUFA4L2/NDUFAF3/NDUFAF4/NDUFS4/NDUFB7/UQCRFS1/NDUFS3/NDUFA12/MAPK12/HRAS/NDUFA9/NPR1/NDUFAF1/NDUFB9/CREB3L1/MT-ND6/NDUFS7/ADCY5/NDUFV1/MLST8/UQCRC1/CYC1/DPF3/NDUFA8/ACTL6A/COX16/COA3/COX10	6.83153826089076
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	46/1237	138/9376	2.52654271085961	NDUFV3/PPA1/NDUFA4/UQCRH/COX5B/COX6C/MT-CO3/COX5A/MT-CO1/MT-CO2/NDUFV2/NDUFC1/NDUFS5/COX7C/ATP6V1B1/COX8C/NDUFA6/COX6B1/NDUFB2/NDUFB11/NDUFB4/NDUFC2/NDUFS8/NDUFS2/NDUFA3/NDUFAB1/COX7B/NDUFB3/COX7A1/NDUFA4L2/PPA2/NDUFS4/NDUFB7/UQCRFS1/NDUFS3/ATP6V1C2/NDUFA12/NDUFA9/NDUFB9/MT-ND6/NDUFS7/NDUFV1/UQCRC1/CYC1/NDUFA8/COX10	7.0427859289695
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	66/1237	238/9376	2.10191368382438	RPL22L1/C1R/RPS26/RPL29/RPL36/RPSA/RPL22/RPL38/RPL5/RPL14/RPL35/RPS5/RPL35A/RPL24/RPL6/RPS7/RPL19/RPL27/RPL21/RPL7A/RPL36AL/RPL23A/RPS27/RPL32/RPS3A/RPL37/RPL39/RPL7/RPS13/RPL37A/RPS23/RPS4X/RPS15/RPL18/RPL15/RPL12/RPLP0/RPS6/RPS3/RPL18A/RPS19/RPS27A/RPS24/RPL3/RPL8/RPLP2/RPS14/RPL11/RPL28/RPS2/RPS18/RPL13/RPL30/RPL10/RPS9/RPS25/UBA52/RPL4/RPS29/RPL23/C1S/CFD/MMP3/RPL26L1/RSL24D1/MAPK12	6.71267222962854
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	63/1237	227/9376	2.10359723503289	MGST1/CYBA/NDUFV3/NDUFA4/GRB2/UQCRH/MGST3/COX5B/COX6C/MT-CO3/COX5A/MT-CO1/MT-CO2/ACP1/NDUFV2/NDUFC1/NDUFS5/COX7C/COX8C/VDAC1/NDUFA6/VDAC2/COX6B1/NDUFB2/GSTA4/NDUFB11/NDUFB4/NDUFC2/SLC25A6/PTEN/CBR1/NDUFS8/SLC25A5/NDUFS2/NDUFA3/NDUFAB1/COX7B/NDUFB3/COX7A1/SLC26A1/NDUFA4L2/VDAC3/AKT1/NDUFS4/NDUFB7/UQCRFS1/NDUFS3/NDUFA12/MAPK12/HRAS/NDUFA9/NDUFB9/NQO1/MT-ND6/NDUFS7/NDUFV1/UQCRC1/MAP2K2/CYC1/SLC25A4/NDUFA8/KEAP1/PRKCD	6.56178025388112
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	19/1237	36/9376	4.00035929219438	RPA3/SSBP1/RNASEH2A/RNASEH2C/MCM7/POLD2/FEN1/MCM6/MCM5/POLD3/PRIM1/RFC5/RFC4/POLE4/RPA2/POLA2/POLE2/PCNA/DNA2	7.03130667720604
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/1237	157/9376	2.26906065115417	LEP/NDUFV3/NDUFA4/UQCRH/COX5B/COX6C/MT-CO3/COX5A/MT-CO1/MT-CO2/NDUFV2/NDUFC1/NDUFS5/COX7C/COX8C/NDUFA6/COX6B1/CDC42/NDUFB2/NDUFB11/NDUFB4/NDUFC2/TGFB1/NDUFS8/NDUFS2/NDUFA3/NDUFAB1/COX7B/NDUFB3/COX7A1/PPARG/NDUFA4L2/AKT1/EIF2S1/NDUFS4/NDUFB7/UQCRFS1/NDUFS3/NDUFA12/MAPK12/NDUFA9/NDUFB9/NDUFS7/NDUFV1/UQCRC1/CYC1/NDUFA8	6.25137081603669
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	35/1237	116/9376	2.28695676414016	GPT2/PFKP/TKT/ADH5/PKM/PGK1/ENO1/TALDO1/TPI1/GAPDH/ALDOA/ACAT2/PGAM1/PHGDH/MDH2/PRPS2/GPI/MDH1/ALDOC/IDH2/PDHA1/RPIA/PFKM/ACAT1/HK2/FH/PSAT1/PGLS/ECHS1/PGP/ALDH6A1/PDHB/ACO2/SUCLG1/PCCB	5.43716386426673
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	26/1237	75/9376	2.62760441929399	CBS/GPT2/PFKP/TKT/PKM/PGK1/ENO1/TALDO1/TPI1/GAPDH/ALDOA/PGAM1/PHGDH/PRPS2/ARG2/ALDOC/IDH2/RPIA/PFKM/CTH/ASNS/PSAT1/ASL/PYCR2/BCAT2/ACO2	5.51695744021409
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	40/1237	144/9376	2.10545225904967	PSMB2/PSMA7/PSMA4/PSMB1/PSMB6/PSMB3/VDAC1/PSMB5/PSMA1/VDAC2/PSMD11/NOP56/PSMA3/SLC25A6/PSMD4/SLC25A5/ADRM1/PSMC3/PSMB4/PSMD3/PSMD2/PSMD7/PSMD12/VDAC3/AKT1/PSMD14/PSMC4/PSMD13/PSMB7/PSMD6/PLCB3/PSMC5/RORA/PSMC1/PSMC6/SLC25A4/PSMD1/PSMC2/NRBF2/OMA1	5.21144673672262
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	26/1237	78/9376	2.52654271085961	PFKP/LSM5/HSPD1/ENO1/LSM3/LSM2/LSM4/DCPS/EXOSC5/EXOSC8/EXOSC3/LSM6/EXOSC9/LSM7/PFKM/PABPC4/EXOSC7/NUDT16/DCP1A/BTG3/PNPT1/EXOSC2/HSPA9/CNOT10/DIS3/MPHOSPH6	5.27772131572012
Genetic Information Processing	Transcription	hsa03040	Spliceosome	57/1237	243/9376	1.7779374631975	LSM5/SNRPF/SNRPD1/RBM8A/SNRPD2/U2AF1/SNRPB/HNRNPA3/SNRPG/SRSF9/HNRNPA1/ALYREF/SNRPD3/HNRNPC/LSM3/LSM2/SNRPE/LSM4/HNRNPM/SNRPA1/MAGOH/SRSF3/THOC7/SRSF7/SNRPA/TXNL4A/RBM25/LSM6/EIF4A3/HNRNPU/THOC3/LSM7/PPIH/SRSF2/CWC15/SNRNP40/SNRNP70/MAGOHB/PRPF40A/RBMX/BCAS2/U2SURP/PRPF38A/SNRPB2/RBM17/DDX46/DDX23/EFTUD2/GPKOW/PUF60/SF3B4/SNRPC/SF3B3/TCERG1/PPIE/PRPF4/SF3B2	4.78989571481158
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	54/1237	233/9376	1.75665201355904	COL1A1/COL3A1/TPM2/COL1A2/MYL9/DCN/COL6A2/LMNB2/DSC2/COL6A3/TPM4/ENO1/ACTG1/ACTB/MYL4/DSP/LMNB1/COL5A2/DIAPH3/ATP1B3/TNNT1/MYL3/FLNC/SPTBN1/NID1/TLN1/VCAN/SGCB/TPM3/COL6A1/CSRP1/CAPZB/COL9A3/LMOD1/MYH10/TNNC1/TMOD1/NID2/LAMA2/LBR/SYNPO2/SDC1/DSG2/THBS1/PDLIM1/PDLIM2/DES/TNNT2/VCL/SNTA1/LAMA1/COL4A5/DMD/PDLIM7	4.55947413657541
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1237	85/9376	2.31847448761234	RRM2/TYMS/TK1/ADA/NME1/IMPDH2/HDDC2/DTYMK/DUT/NME2/GMPS/AK1/AK2/APRT/IMPDH1/AK4/PNP/ENPP1/ADK/RRM1/NTPCR/ADSL/NUDT16/DCTPP1/NT5M/NT5C	4.76030661909982
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	40/1237	157/9376	1.93111544779078	CCNB1/HLA-C/HLA-G/CCNE1/CALM3/CALM1/CCNB2/PPP1CA/VDAC1/CDK1/VDAC2/CHEK1/CCNA2/MYBL2/SLC25A6/EIF4EBP1/CCND3/PTEN/MYC/TGFB1/SLC25A5/VDAC3/AKT1/MAPK12/HRAS/CDK2/CCND2/CAPN1/TP53/E2F1/PPP1CB/CHEK2/CDC25A/MAP2K2/MAP2K6/FOXM1/SLC25A4/E2F3/E2F5/CCNE2	4.58665858986838
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/1237	71/9376	2.45537249365229	LDHB/PFKP/LDHA/SLC16A3/PKM/PGAM1/SLC2A1/PTEN/MYC/SLC7A5/IDH2/PDHA1/PDGFRA/AKT1/PFKM/HK2/HRAS/FGFR3/TP53/PDGFRB/RET/MAP2K2/PDHB	4.79877195357953
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	22/1237	67/9376	2.48883311816021	LDHB/PFKP/ADH5/LDHA/PKM/PGK1/ENO1/TPI1/GAPDH/ALDOA/PGAM1/ALDH7A1/GPI/ALDH2/ALDOC/PDHA1/PFKM/HK2/ALDH1B1/PDHB/PGM1/ALDH3B2	4.76778728182319
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	42/1237	174/9376	1.82956541131213	TUSC3/HSPA5/PDIA6/CALR/MAN1A2/PDIA3/OSTC/PDIA4/LMAN1/SSR2/HSP90B1/SSR3/DAD1/LMAN2/SEC61B/HSP90AB1/ERP29/DNAJB11/DNAJC3/VCP/TMEM258/SAR1A/STT3B/KRTCAP2/CKAP4/EDEM2/EIF2S1/SIL1/BAG2/DERL2/CAPN1/ERLEC1/STT3A/UBXN1/UGGT1/RAD23A/CUL1/PREB/NSFL1C/DNAJB12/HSPBP1/DERL1	4.30595125683979
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/1237	63/9376	2.40623115319962	RPA3/CDK7/POLD2/POLR2I/POLR2H/POLR2F/GTF2H5/POLR2L/POLD3/RFC5/RFC4/POLE4/POLR2E/RPA2/MNAT1/POLE2/PCNA/RAD23A/POLR2G/ERCC2	4.3658333288211
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/1237	87/9376	2.09093189864243	TPM2/TPM4/UQCRH/COX5B/COX6C/MT-CO3/COX5A/MT-CO1/MT-CO2/MYL4/COX7C/COX8C/COX6B1/ATP1B3/MYL3/TPM3/COX7B/COX7A1/TNNC1/UQCRFS1/SLC8A3/UQCRC1/CYC1/TNNT2	3.98526999370635
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/1237	23/9376	3.29549049242557	RPA3/SSBP1/POLD2/POLD3/RFC5/RFC4/RPA2/EXO1/PCNA/MSH2	4.29683733487343
Cellular Processes	Cell motility	hsa04814	Motor proteins	43/1237	194/9376	1.68002066856128	TPM2/MYO1B/MYL9/TUBB/TUBA1B/TUBB6/TUBA1C/TPM4/TUBB4B/DYNLL1/ACTG1/MYL6/ACTB/MYL4/CENPE/ACTA2/MYO10/MYL12A/MYL6B/TNNT1/MYL3/TPM3/CAPZB/TUBG1/KIFC1/MYH10/KIF20B/TNNC1/KIF4A/KIF23/KIF2C/KIF11/KIF14/TNNT2/KIF22/KIF15/KIFAP3/MYO5C/MYO1E/DYNC1LI1/KIF18A/DYNC2LI1/DCTN5	3.73112069050903
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/1237	128/9376	1.83569118835893	RRM2/ADA/PAICS/NME1/PDE4D/PRPS2/IMPDH2/HDDC2/NME2/GMPS/AK1/AK2/APRT/IMPDH1/AK4/PNP/ENPP1/ADK/ATIC/NPR1/RRM1/NTPCR/ADSL/ADCY5/PPAT/NUDT16/GART/NT5M/NT5C/PGM1/PFAS	3.71117864932657
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	47/1237	224/9376	1.59036840281788	PTTG1/HLA-C/HLA-G/CDC20/CCNE1/RANBP1/CALR/RAN/CCNB2/SLC2A1/MAD2L1/VDAC1/VDAC2/ANAPC11/CHEK1/FDPS/CCNA2/TLN1/SLC25A6/CCND3/PTEN/MYC/TGFB1/SLC25A5/VDAC3/AKT1/STAT5B/BUB3/HRAS/CREB3L1/CDK2/CCND2/XPO1/ADCY5/BUB1B/TP53/E2F1/CHEK2/NFYB/MAP2K2/CDKN2C/MSX2/SLC25A4/E2F3/ESPL1/CCNE2/ANAPC1	3.48637479157521
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	32/1237	138/9376	1.75759492929364	CCNB1/PTTG1/CDC20/CCNE1/CALM3/CALM1/CCNB2/PPP1CA/MAD2L1/YWHAE/CDK1/ANAPC11/SMC1A/AURKA/YWHAQ/IGF1/PKMYT1/PLK1/PPP2R1A/MAPK12/FBXO5/CDK2/BUB1/SPDYC/ADCY5/CDC25C/PPP2R1B/PPP1CB/CUL1/ESPL1/CCNE2/ANAPC1	3.49520447081588
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	37/1237	170/9376	1.64968377003186	JAM3/MYL9/CLDN6/CLDN10/TUBA1B/TUBA1C/ACTN1/ACTG1/MYL6/ACTB/MYL12A/ACTN4/MYL6B/CDC42/ARPC3/ACTR3/ARPC5/ARPC1A/RAB13/MYH10/CLDN7/PPP2R1A/PRKCZ/CLDN3/CTTN/IGSF5/HSPA4/PPP2R1B/RDX/MAGI1/MPDZ/PCNA/LLGL1/CRB3/MARVELD2/ACTR3B/DLG3	3.33254449616649
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	20/1237	75/9376	2.02123416868768	CCNB1/RRM2/CCNE1/PERP/SIVA1/CCNB2/CDK1/CHEK1/CCND3/PTEN/EI24/IGF1/GTSE1/SFN/CDK2/CCND2/THBS1/TP53/CHEK2/CCNE2	3.46159384820686
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/1237	31/9376	2.68954546639894	PFKP/TKT/TALDO1/ALDOA/PRPS2/GPI/ALDOC/RPIA/PFKM/PGLS/PGM1	3.67321239508432
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	33/1237	149/9376	1.67870958641007	NDUFV3/NDUFA4/NDUFV2/NDUFC1/NDUFS5/NDUFA6/GNG11/NDUFB2/NDUFB11/NDUFB4/NDUFC2/GNAI1/NDUFS8/NDUFS2/NDUFA3/NDUFAB1/NDUFB3/NDUFA4L2/NDUFS4/NDUFB7/NDUFS3/NDUFA12/MAPK12/NDUFA9/NDUFB9/GNAI3/GNB2/MT-ND6/NDUFS7/ADCY5/PLCB3/NDUFV1/NDUFA8	3.25560585669119
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	14/1237	47/9376	2.25776157140646	LDHB/ADH5/LDHA/PKM/ACAT2/ALDH7A1/MDH2/MDH1/ALDH2/PDHA1/ACAT1/ALDH1B1/FH/PDHB	3.36988179728053
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1237	20/9376	3.03185125303153	EBP/SQLE/LBR/HSD17B7/SC5D/CYP51A1/DHCR7/TM7SF2	3.54606560520086
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	31/1237	142/9376	1.65470755007002	MGST1/CYBA/MMP2/CALM3/CAV1/HSP90B1/MGST3/CALM1/TXN2/GSTP1/ACTG1/ACTB/HSP90AB1/GSTA4/RAC3/CDH5/GPC1/BMP4/CTNNB1/AKT1/NPPC/MAPK12/PRKCZ/NQO1/SDC1/TP53/PLAT/MAP2K6/MAPK7/KEAP1/SUMO1	3.06465470838526
NA	NA	hsa04518	Integrin signaling	33/1237	154/9376	1.62420602840975	COL1A1/COL1A2/COL6A2/LAMA4/PGF/COL6A3/ACTN1/FERMT2/ACTG1/ACTB/ACTN4/CDC42/RAC3/TLN1/CDH1/CCND3/COL6A1/TGFB1/FLT4/CTNNB1/IGF1/COL9A3/PDGFRA/AKT1/TNXB/LAMA2/CCND2/THBS1/LAMC3/PDGFRB/VCL/LAMA1/COL4A5	3.04481369201311
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/1237	203/9376	1.53086085436321	COL1A1/COL1A2/MYL9/COL6A2/LAMA4/PGF/CAV1/COL6A3/ACTN1/GRB2/ACTG1/ACTB/PPP1CA/MYL12A/ACTN4/CDC42/RAC3/TLN1/CCND3/PTEN/COL6A1/FLT4/CTNNB1/IGF1/PAK4/COL9A3/ARHGAP5/PDGFRA/AKT1/TNXB/HRAS/LAMA2/CCND2/THBS1/FYN/LAMC3/PDGFRB/PPP1CB/VCL/LAMA1/COL4A5	2.98097262389927
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/1237	54/9376	2.10545225904967	LDHB/CBS/LDHA/PHGDH/SRM/MDH2/MDH1/AHCY/CISD1/ADI1/SMS/CTH/GCLM/PSAT1/BCAT2	3.17590341240589
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/1237	44/9376	2.23943558462556	HMGB1/POLD2/APEX1/PARP1/FEN1/POLD3/RFC5/NTHL1/RFC4/POLE4/POLE2/PCNA/TDP1	3.21253522019284
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1237	50/9376	2.12229587712207	ODC1/CKMT1A/ALDH7A1/SRM/ALDH2/ARG2/CKB/P4HA2/SMS/MAOB/CKMT1B/ALDH1B1/GAMT/PYCR2	3.10191310695056
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/1237	106/9376	1.71614221869709	CCNE1/GRB2/HSP90B1/GSTP1/HSP90AB1/MMP3/PTEN/CTNNB1/IGF1/ZEB1/PDGFRA/AKT1/HRAS/CREB3L1/CDK2/TP53/PDGFRB/E2F1/ETV5/MAP2K2/PLAT/E2F3/CDKN1B/CCNE2	2.89066195609338
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1237	59/9376	1.92702410150309	MGST1/RRM2/ODC1/PRDX6/MGST3/GSTP1/SRM/GSTA4/GGCT/IDH2/TXNDC12/SMS/RRM1/GCLM/LANCL1	2.78460723550381
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/1237	15/9376	3.03185125303153	ACP1/AK1/AK2/AK4/NTPCR/TPK1	3.07016263450827
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	31/1237	154/9376	1.52576929941522	GGH/NME1/ALAS2/MTHFD1L/ALDH2/VKORC1/NME2/AK1/AK2/DHFR/GCH1/AK4/COQ3/HMBS/ALDH1B1/NQO1/ALAD/ADSL/GCLM/UMPS/PSAT1/UROD/MMAB/MTHFD1/BCAT2/GMPPA/LIAS/HSD17B6/GGCX/TPK1/COX10	2.56464931262845
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1237	34/9376	2.22930239193495	POLR1D/POLR2I/POLR2H/POLR2F/POLR3G/POLR2L/POLR1E/POLR2E/POLR3F/POLR2G	2.79938877914225
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/1237	56/9376	1.8949070331447	TUSC3/MAN1A2/OSTC/DAD1/SRD5A3/ALG9/B4GALT1/TMEM258/STT3B/KRTCAP2/MGAT3/STT3A/DOLPP1/DPAGT1	2.61847807816302
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	23/1237	108/9376	1.61418006527142	KPNA2/RAN/RBM8A/ALYREF/NUP37/MAGOH/THOC7/SAP18/EIF4A3/KPNB1/THOC3/PNN/MAGOHB/XPO1/UPF3B/UPF1/CSE1L/IPO8/IPO5/NMD3/NDC1/SUMO1/AAAS	2.50264670489425
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1237	110/9376	1.58483133681193	LDHB/PFKP/TIMP1/ANGPT4/LDHA/PGK1/ENO1/GAPDH/ALDOA/RPS6/SLC2A1/EIF4EBP1/ALDOC/IGF1/PDHA1/AKT1/PFKM/HK2/EPO/MAP2K2/PDHB/CDKN1B/EGLN1	2.40528085026677
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1237	110/9376	1.58483133681193	CCNB1/CCNB2/MAD2L1/CDK1/HSP90AB1/ANAPC11/CCNA2/AURKA/GNAI1/IGF1/PKMYT1/PLK1/AKT1/MAPK12/GNAI3/CDK2/BUB1/SPDYC/ADCY5/CDC25C/CDC25A/KIF22/ANAPC1	2.40528085026677
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1237	31/9376	2.20053719978095	SEC11C/HSPA5/SPCS3/SEC11A/SRP14/SEC61B/SPCS1/SRP72/SGTA	2.61006774348264
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1237	59/9376	1.79855582806955	RRM2/TYMS/TK1/NME1/HDDC2/DTYMK/DUT/NME2/ENPP1/RRM1/UMPS/DCTPP1/NT5M/NT5C	2.39871253961005
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1237	28/9376	2.16560803787966	GGH/AKR1B1/CBR1/DHFR/GCH1/PCBD2/MOCOS/PCBD1	2.40800376263475
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/1237	39/9376	1.94349439296893	CBS/TYMS/MTHFD1L/ALDH7A1/AHCY/DHFR/CTH/ATIC/GART/MTHFD1	2.30172222632826
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/1237	205/9376	1.36803044344106	HLA-C/HLA-G/CCNE1/CALR/PDIA3/SKP2/PSMD11/CCNA2/PSMD4/CCND3/MYC/ADRM1/PSMC3/PSMD3/PSMD2/PSMD7/PSMD12/AKT1/PSMD14/PSMC4/MAPK12/PSMD13/CDK2/CCND2/PSMD6/PSMC5/TP53/E2F1/PSMC1/MAP2K6/PSMC6/PSMD1/TAB1/E2F3/CDKN1B/PSMC2/CCNE2	2.07700380684314
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/1237	116/9376	1.50285730214925	CYBA/JAM3/MYL9/MMP2/CLDN6/CLDN10/ACTN1/ACTG1/ACTB/THY1/MYL12A/ACTN4/CDC42/CDH5/GNAI1/CTNNB1/CXCL12/ARHGAP5/CLDN7/MAPK12/CLDN3/GNAI3/VCL	2.12448283292195
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	38/1237	212/9376	1.35861258980186	PGF/CALM3/ANGPT4/CALM1/PFN1/ACTG1/ACTB/CDC42/ID1/RAC3/RALB/ENAH/TLN1/CDH1/GNAI1/FLT4/CTNNB1/IGF1/PDGFRA/EPHA2/AKT1/MAPK12/HRAS/PRKCZ/GNAI3/SIPA1L2/FGFR4/FGFR3/EFNA3/THBS1/FGF7/ADCY5/PLCB3/PDGFRB/MAP2K2/MAP2K6/MAGI1/EFNA4	2.05890299915476
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/1237	63/9376	1.68436180723974	ACAT2/ALDH7A1/ALDH2/PLOD1/ACAT1/DHTKD1/GCDH/ALDH1B1/EZH2/HYKK/ECHS1/SMYD2/AASS/COLGALT1	2.12469307070979
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1237	93/9376	1.54852617762363	MYL9/ACTN1/ACTG1/ACTB/ACP1/MYL12A/ACTN4/CDC42/RAC3/CDH1/CDH5/CTNNB1/HEG1/SNAI2/RASIP1/FYN/ARHGAP29/VCL/CSNK2A1	2.07242881133759
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	19/1237	93/9376	1.54852617762363	LAMA4/CCNE1/SKP2/PTEN/CKS2/MYC/CKS1B/AKT1/TRAF4/LAMA2/CDK2/TP53/LAMC3/E2F1/LAMA1/COL4A5/E2F3/CDKN1B/CCNE2	2.07242881133759
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1237	30/9376	2.02123416868768	MDH2/MDH1/IDH2/PDHA1/FH/PDHB/ACO2/SUCLG1	2.18402718538946
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1237	41/9376	1.84868978843386	CBS/ALAS2/PGAM1/ALDH7A1/PHGDH/MAOB/CTH/GAMT/PSAT1/GCAT	2.12309148099458
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/1237	41/9376	1.84868978843386	RPA3/SSBP1/POLD2/RAD51/POLD3/RAD54L/RPA2/BRCA1/BRCC3/BLM	2.12309148099458
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1237	41/9376	1.84868978843386	MMP2/CDH1/MYC/HRAS/FGFR3/THBS1/TP53/E2F1/MAP2K2/E2F3	2.12309148099458
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/1237	48/9376	1.73699811371598	HSD17B10/ACAT2/ALDH7A1/ALDH2/ACAT1/ALDH1B1/ECHS1/ALDH6A1/BCAT2/OXCT1/PCCB	1.99561927539708
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/1237	103/9376	1.47177245292793	RBM8A/ALYREF/PPP1CA/MAGOH/PAPOLA/SAP18/EIF4A3/PNN/PABPC4/PPP2R1A/MAGOHB/UPF3B/GSPT1/PPP2R1B/UPF1/PPP1CB/CSTF2/PELO/CPSF3/FIP1L1	1.87683470208131
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1237	37/9376	1.8436933295462	CDH1/TPM3/MYC/CTNNB1/PPARG/HRAS/TP53/RET/MAP2K2	2.00456550930409
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1237	43/9376	1.7627042168788	ADH5/ACAT2/ALDH7A1/CPT1C/ALDH2/ACAT1/GCDH/ALDH1B1/ECI2/ECHS1	1.95418063894393
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1237	27/9376	1.96508877511303	SCD/ELOVL6/ELOVL2/ACOT4/TECR/HSD17B12/FADS1	1.95772429495233
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1237	44/9376	1.72264275740428	TUSC3/MAN1A2/OSTC/DAD1/ALG9/B4GALT1/TMEM258/STT3B/KRTCAP2/STT3A	1.8730423255355
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1237	44/9376	1.72264275740428	CDK7/TAF9/GTF2A2/GTF2H5/TAF10/TAF15/MNAT1/ERCC2/TAF8/GTF2F1	1.8730423255355
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/1237	157/9376	1.35178081345355	BIRC5/ACTG1/ACTB/PPP1CA/YWHAE/ID1/CDH1/WNT10B/CCND3/YWHAQ/MYC/TGFB1/BMP4/CTNNB1/BMP7/WNT3A/CSNK1E/SNAI2/WNT2/TEAD4/PPP2R1A/PRKCZ/CCND2/PPP2R1B/PPP1CB/LLGL1/AXIN1/DLG3	1.73286620215128
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1237	12/9376	2.52654271085961	VKORC1/COQ3/NQO1/GGCX	2.06278442746066
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	58/1237	362/9376	1.21441555715351	COL1A1/COL1A2/COL6A2/LAMA4/CCNE1/PGF/ANGPT4/COL6A3/GRB2/HSP90B1/RPS6/YWHAE/GNG11/HSP90AB1/EIF4EBP1/CCND3/PTEN/YWHAQ/COL6A1/MYC/FLT4/IGF1/COL9A3/PDGFRA/EPHA2/AKT1/TNXB/GYS1/PPP2R1A/CDC37/HRAS/LAMA2/GNB2/CREB3L1/CDK2/CCND2/EPO/FGFR4/FGFR3/EFNA3/THBS1/FGF7/TP53/LAMC3/PDGFRB/RET/PPP2R1B/MLST8/MAP2K2/BRCA1/MAGI1/LAMA1/GHR/PKN3/COL4A5/CDKN1B/EFNA4/CCNE2	1.62194739692561
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1237	13/9376	2.33219327156271	XRCC5/XRCC6/FEN1/PRKDC	1.87377035679642
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1237	35/9376	1.73248643030373	PFKP/TPI1/ALDOA/AKR1B1/ALDOC/PFKM/HK2/GMPPA	1.69247352360177
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1237	54/9376	1.54399832330309	RPA3/UBE2T/RAD51/FANCB/FANCI/RPA2/BRCA1/RMI2/FANCD2/BLM/FANCF	1.56287719996757
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	19/1237	105/9376	1.37155175732379	BNIP3/TOMM20/RPS27A/UBA52/PHB2/VCP/TOMM40/MTX1/EIF2S1/HRAS/USP15/TP53/E2F1/PGAM5/MAP1LC3A/FUNDC1/FKBP8/CSNK2A1/SAMM50	1.49257321080545
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1237	36/9376	1.68436180723974	PYGL/GYG2/GPI/GBE1/ENPP1/GYS1/HK2/PGM1	1.60379383808738
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1237	42/9376	1.62420602840975	ACAT2/ALDH7A1/ALDH2/MAOB/ACAT1/DHTKD1/GCDH/ALDH1B1/ECHS1	1.58053336911812
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	33/1237	200/9376	1.25063864187551	MYO1B/CASP4/CLDN6/CLDN10/TUBB/TUBA1B/TUBB6/TUBA1C/TUBB4B/TMBIM6/NCL/GAPDH/ACTG1/RPS3/TMED10/ACTB/MYO10/CDC42/ARPC3/ACTR3/ARPC5/ARPC1A/MYH10/CLDN7/MAPK12/CLDN3/CTTN/FYN/MYO5C/MYO1E/TAB1/ACTR3B/TIRAP	1.39675838678981
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/1237	248/9376	1.22252066654497	CASP4/MYL9/TUBB/TUBA1B/TUBB6/TUBA1C/TUBB4B/HSP90B1/TXN2/DYNLL1/GAPDH/PFN1/ACTG1/ANXA2/RPS3/ACTB/MYL12A/CDC42/HSP90AB1/ARPC3/ACTR3/ARPC5/ARPC1A/MYC/CTNNB1/PIK3C2G/AKT1/ELMO1/MAPK12/HRAS/MAP2K2/MAP2K6/FBXO22/CSE1L/TAB1/DYNC1LI1/DYNC2LI1/DCTN5/ACTR3B/TIRAP	1.38450121322907
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1237	14/9376	2.16560803787966	ST3GAL1/B4GALT1/CHST2/B4GALT4	1.7014421868399
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1237	31/9376	1.71152893316296	ACAT2/MDH2/MDH1/ACAT1/PGP/ACO2/PCCB	1.54692309188096
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	52/1237	333/9376	1.18360559427657	COL1A1/COL1A2/HLA-C/COL6A2/HLA-G/LAMA4/CCNE1/COL6A3/PKM/GRB2/ATP6V1B1/CDC42/CCNA2/WNT10B/EIF4EBP1/CCND3/PTEN/HEY1/COL6A1/CTNNB1/TUBG1/COL9A3/WNT3A/AKT1/TNXB/ATP6V1C2/WNT2/PPP2R1A/HRAS/LAMA2/PRKCZ/CREB3L1/CDK2/CCND2/THBS1/TP53/LAMC3/PDGFRB/PPP2R1B/E2F1/MAP2K2/PSMC1/MAGI1/LLGL1/LAMA1/MAML3/AXIN1/COL4A5/CDKN1B/CRB3/CCNE2/DLG3	1.32995432059698
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/1237	101/9376	1.35082481570712	COL1A1/COL3A1/COL1A2/MMP2/CDC42/PLCD4/TGFB1/AKT1/STAT5B/MAPK12/HRAS/PRKCZ/PLCB3/PLCD1/F3/COL4A5/CDKN1B/PRKCD	1.3819075744214
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/1237	142/9376	1.28106390973163	UBE2C/CDC20/RPS27A/SKP2/UBE2L3/UBA52/UBE2F/ANAPC11/CBLB/FBXW7/UBE2E3/UBE2N/UBE2S/HERC3/RNF7/UBE2U/BRCA1/UBE2M/RHOBTB1/UBA1/KEAP1/SAE1/CUL1/ANAPC1	1.31564671008313
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1237	122/9376	1.30469008839471	PFKP/ACTG1/ACTB/SLC2A1/ATP1B3/PLCD4/MYC/BMP4/CTNNB1/DIO3/AKT1/PFKM/MED12L/HRAS/PLCB3/MED30/TP53/MAP2K2/PLCD1/HDAC3/SLC16A2	1.320560973182
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1237	89/9376	1.36262977664338	TUBB/TUBA1B/TUBB6/TUBA1C/GRB2/TUBB4B/CDK1/GNAI1/PDGFRA/HRAS/GNAI3/ADCY5/PLCB3/PDGFRB/MAP2K2/MAPK7	1.34000280294124
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	28/1237	170/9376	1.24840933948357	MGST1/GRB2/MGST3/GSTP1/ACTG1/ACTB/SMARCA2/GSTA4/WNT10B/PTEN/MYC/TGFB1/CTNNB1/WNT3A/AKT1/WNT2/HRAS/NQO1/TP53/E2F1/MAP2K2/LRP6/DPF3/KEAP1/AXIN1/E2F3/TXNRD1/ACTL6A	1.27421249425967
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/1237	70/9376	1.40764522462178	HLA-C/HLA-G/CAV1/CD55/ACTG1/ACTB/RAC3/SGCB/LAMA2/FYN/SNTA1/LAMA1/DMD	1.33454990531145
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1237	33/9376	1.60779990691066	GPT2/IDH2/PDHA1/DHTKD1/BCAT2/PDHB/ACO2	1.36351333145187
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1237	52/9376	1.4576207947267	CGA/CYP11A1/IGF1/ACOT4/CYP19A1/HSD3B1/LHB/ADCY5/HSD17B7/CYP2J2	1.2900045857826
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1237	78/9376	1.36044607507825	CAV1/ACTG1/ACTB/CDC42/ARPC3/ACTR3/ARPC5/ARPC1A/CDH1/CTNNB1/ELMO1/CTTN/VCL/ACTR3B	1.24617144353394
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/1237	105/9376	1.2993648227278	TPM2/TPM4/ACTG1/ACTB/MYL3/SGCB/TPM3/TGFB1/IGF1/TNNC1/LAMA2/SLC8A3/ADCY5/DES/TNNT2/SNTA1/LAMA1/DMD	1.20258861882236
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1237	99/9376	1.30155230559434	TPM2/TPM4/ACTG1/ACTB/MYL3/SGCB/TPM3/TGFB1/IGF1/TNNC1/LAMA2/SLC8A3/DES/TNNT2/SNTA1/LAMA1/DMD	1.17587575559336
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1237	28/9376	1.62420602840975	ELOVL6/ELOVL2/ACOT4/TECR/HSD17B12/ECHS1	1.2895333733321
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1237	22/9376	1.72264275740428	ALDH7A1/ALDH2/MAOB/ALDH1B1/ALDH3B2	1.3228825134828
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1237	93/9376	1.30402204431464	MMP2/CALM3/CGA/GRB2/CALM1/CDC42/MMP14/MAPK12/HRAS/LHB/ADCY5/PLCB3/MAP2K2/MAP2K6/MAPK7/PRKCD	1.14864899729858
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/1237	107/9376	1.27507762977961	LDHB/PYGL/PFKP/CALM3/LDHA/PKM/CALM1/PGAM1/SLC2A1/CPT1C/PRMT1/PDHA1/AKT1/PFKM/GYS1/CREB3L1/PLCB3/PDHB	1.11561844261534
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1237	253/9376	1.16840117458725	CASP4/BNIP3/MYL9/ACTN1/U2AF1/PFN1/ACTG1/RPS27A/ACTB/UBA52/VDAC1/MYL12A/ACTN4/CDC42/ARPC3/ACTR3/ARPC5/ARPC1A/TLN1/PLCD4/UBE2N/CBX3/AKT1/HK2/GLMN/ELMO1/MAPK12/CTTN/CAPN1/PLCB3/TP53/PLCD1/VCL/CUL1/TAB1/MAP1LC3A/PRKCD/ACTR3B/SHARPIN	1.05857468334038
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/1237	204/9376	1.18896127569864	COL1A1/COL1A2/DCN/MMP2/LUM/CAV1/GRB2/ACTG1/RPS6/ACTB/PPP1CA/CDC42/WNT10B/GPC1/MYC/TGFB1/ANK1/CTNNB1/IGF1/WNT3A/AKT1/WNT2/TWIST1/MAPK12/HRAS/CTTN/SDC1/THBS1/TP53/RDX/PPP1CB/MAP2K2	1.06375309507127
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1237	23/9376	1.64774524621279	ACAT2/FDPS/ACAT1/NUS1/ZMPSTE24	1.21248855815251
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1237	42/9376	1.44373869191977	VDAC2/VDAC3/SLC3A2/GCLM/SLC40A1/TP53/MAP1LC3A/CP	1.12357743730032
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1237	82/9376	1.2940828519037	MGST1/RRM2/TK1/NME1/MGST3/GSTP1/GSTA4/IMPDH2/DUT/NME2/GMPS/IMPDH1/RRM1/UMPS	1.04270212168847
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1237	130/9376	1.22440146757042	COL1A1/COL3A1/COL1A2/MMP2/GRB2/ACTA2/GNG11/GNAI1/TGFB1/AKT1/MAPK12/HRAS/PRKCZ/RLN2/GNAI3/GNB2/CREB3L1/ADCY5/PLCB3/MAP2K2/COL4A5	1.00439695689821
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/1237	89/9376	1.27746541560317	COL1A1/COL1A2/COL6A2/LAMA4/COL6A3/HMMR/COL6A1/COL9A3/TNXB/LAMA2/SDC1/THBS1/LAMC3/LAMA1/COL4A5	1.02530034369777
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1237	30/9376	1.51592562651576	ABCG2/TYMS/GGH/DHFR/ATIC/GART	1.10336652307422
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/1237	76/9376	1.29651533846743	CALM3/GRB2/CALM1/PTEN/IGF1/PDGFRA/AKT1/HRAS/TP53/PDGFRB/E2F1/MAP2K2/E2F3	1.0118064639337
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1237	37/9376	1.43398370075816	GNPNAT1/GPI/NAGK/HK2/CMAS/GMPPA/PGM1	1.03111963514974
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1237	57/9376	1.32975932150506	ACAT2/SCD/ELOVL6/CPT1C/ELOVL2/TECR/ACAT1/HSD17B12/ECHS1/FADS1	0.973497446281717
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1237	31/9376	1.46702479985397	ALDH7A1/ALDH2/ALDH1B1/ECHS1/ALDH6A1/ALDH3B2	1.01535076608012
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	24/1237	154/9376	1.18124074793436	TPM2/CALM3/TPM4/CALM1/MYL4/PPP1CA/ATP1B3/MYL3/GNAI1/CREM/TPM3/ATP2B4/TNNC1/AKT1/PPP2R1A/MAPK12/GNAI3/CREB3L1/SLC8A3/ADCY5/PLCB3/PPP2R1B/PPP1CB/TNNT2	0.884073984782142
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/1237	155/9376	1.17361983988317	CCNE1/CYP11A1/WNT10B/GNAI1/CTNNB1/WDR5/WNT3A/HSD3B1/WNT2/PBX1/GNAI3/CREB3L1/CDK2/FH/ADCY5/PLCB3/E2F1/MAP2K2/CDKN2C/AXIN1/E2F3/CDKN1B/ASH2L/CCNE2	0.849691264168841
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1237	19/9376	1.59571118580607	PDHA1/DHTKD1/PDHB/LIAS	1.01327937903212
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1237	32/9376	1.42118027485853	PFKP/AKR1B1/B4GALT1/PFKM/HK2/PGM1	0.930382561635705
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1237	32/9376	1.42118027485853	LDHB/LDHA/ECHS1/ALDH6A1/SUCLG1/PCCB	0.930382561635705
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1237	59/9376	1.28468273433539	GRB2/CDH1/PTEN/MYC/CTNNB1/AKT1/HRAS/TP53/MAP2K2/AXIN1	0.855133756035038
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	11/1237	66/9376	1.2632713554298	CYP11A1/SRD5A3/STS/CYP19A1/HSD3B1/HSD17B12/HSD11B2/HSD17B7/DHRS9/HSD17B6/DHRS11	0.836730693641108
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1237	73/9376	1.24596626836912	CDH1/PTEN/IGF1/PDGFRA/AKT1/HRAS/FGF7/TP53/PDGFRB/E2F1/MAP2K2/E2F3	0.822451762679644
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1237	27/9376	1.40363483936645	ACAT2/ACAT1/ECHS1/L2HGDH/OXCT1	0.818790718215875
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1237	103/9376	1.17741796234234	COL1A1/COL3A1/COL1A2/COL6A2/COL6A3/SLC6A19/COL5A2/COL14A1/ATP1B3/COL18A1/COL6A1/COL9A3/SLC3A2/COL15A1/SLC8A3/COL4A5	0.705815242984378
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1237	21/9376	1.44373869191977	CHSY1/DSEL/XYLT2/CHST3	0.793596993814151
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1237	21/9376	1.44373869191977	ALDH2/ENPP1/ALDH1B1/BCAT2	0.793596993814151
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	30/1237	205/9376	1.10921387306031	HLA-C/HLA-G/CDC20/CCNE1/RANBP1/ACTN1/PKM/GRB2/SKP2/YWHAE/CDK1/ACTN4/CDC42/CHEK1/CCNA2/CCND3/YWHAQ/GTF2A2/VDAC3/STAT5B/HRAS/CREB3L1/CDK2/CCND2/TP53/PSMC1/HDAC8/HDAC3/CDKN1B/CCNE2	0.616355614457988
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/1237	134/9376	1.13128778098191	MYL9/CALM3/PLA2G2A/CALM1/MYL6/ACTA2/PPP1CA/MYL6B/RAMP1/PPP1R14A/RAMP2/MYH10/NPPC/NPR1/PLA2G10/ADCY5/PLCB3/PPP1CB/MAP2K2/PRKCD	0.596731122197765
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/1237	70/9376	1.19108442083381	GRB2/SLC2A1/CDC42/TGFB1/PAK4/AKT1/HRAS/FH/MAP2K2/PRCC/EGLN1	0.625572631120268
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/1237	214/9376	1.09798351453245	CCNB1/HLA-C/HLA-G/CALM3/CALR/PDIA3/CALM1/CCNB2/CFL1/GNG11/CDK1/CHEK1/RAC3/WEE1/GNAI1/PAK4/AKT1/CFL2/AP1M2/MAPK12/HRAS/RNF7/GNAI3/GNB2/CDC25C/MAP2K2/MAP2K6/CUL1/TAB1/TRIM5/AP1S3	0.565261907424738
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1237	49/9376	1.23749030735981	GALNT2/GALNT1/B4GALT1/GXYLT1/C1GALT1C1/POFUT1/FUT10/COLGALT1	0.649767380166231
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1237	178/9376	1.10713669352275	DKK1/LGR4/RUVBL1/RAC3/CACYBP/APCDD1/WNT10B/CCND3/FRZB/MYC/CTNNB1/RSPO3/WNT3A/CSNK1E/WNT2/SERPINF1/CCND2/PLCB3/TP53/LRP6/LZTS2/CUL1/AXIN1/TBL1X/RNF43/CSNK2A1	0.562582866104441
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	23/1237	157/9376	1.1103913824797	ODC1/CALR/SLC2A1/CPT1C/ARG2/TGFB1/BSG/PPARG/RAB17/UQCRFS1/SLC16A1/ELMO1/PBX1/MAPK12/ATP11A/EPO/ATP11B/THBS1/PANX1/MAP2K2/TYRO3/DUSP5/PROS1	0.543786040602486
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1237	78/9376	1.16609663578136	TPI1/IMPA2/PLCD4/PTEN/ITPKB/SYNJ1/PIK3C2G/INPP4B/PLCB3/PLCD1/ALDH6A1/IPPK	0.574246464836246
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1237	50/9376	1.21274050121261	HBA2/HBA1/GYPA/GYPB/GYPC/TGFB1/SDC1/THBS1	0.58799338262102
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1237	158/9376	1.1033635889197	GRB2/RPS6/SKP2/ATP6V1B1/WNT10B/EIF4EBP1/PTEN/CAB39L/SLC7A5/IGF1/WNT3A/AKT1/SLC3A2/ATP6V1C2/WNT2/HRAS/MLST8/MAP2K2/LAMTOR2/PRR5/LRP6/STRADB/NPRL2	0.510813934108489
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1237	86/9376	1.14575774097122	DSC2/ACTG1/ACTB/DSP/SGCB/CTNNB1/LAMA2/SLC8A3/DSG2/DES/SNTA1/LAMA1/DMD	0.529368336737175
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	21/1237	144/9376	1.10536243600108	LIFR/GRB2/ID3/ID1/WNT10B/MYC/BMP4/CTNNB1/IGF1/WNT3A/AKT1/WNT2/MAPK12/HRAS/FGFR4/FGFR3/DLX5/MAP2K2/MEIS1/AXIN1/TBX3	0.496711385567208
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	33/1237	232/9376	1.0781367602375	MYL9/ACTN1/PFN1/ACTG1/ACTB/PPP1CA/CFL1/MYL12A/ACTN4/CDC42/DIAPH3/ARPC3/ACTR3/RAC3/ARPC5/ENAH/ARPC1A/CXCL12/PAK4/MYH10/PDGFRA/AKT1/CFL2/HRAS/FGFR4/FGFR3/FGF7/PDGFRB/RDX/PPP1CB/MAP2K2/VCL/ACTR3B	0.469803499830894
NA	NA	hsa04517	IgSF CAM signaling	42/1237	299/9376	1.06469692832211	JAM3/MYL9/TUBB/TUBA1B/TUBB6/TUBA1C/ACTN1/GRB2/TUBB4B/DYNLL1/ACTG1/MYL6/ACTB/APP/MYL12A/ACTN4/MYL6B/CDC42/ARPC3/ACTR3/ARPC5/SPTBN1/ARPC1A/CDH1/CTNNB1/ROBO1/PAK4/MYH10/AKT1/CNTNAP2/MAPK12/SLIT2/IGSF5/CLMP/FYN/RDX/MAP2K2/MAGI1/VCL/MPDZ/LRFN4/ACTR3B	0.443233984384977
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1237	16/9376	1.42118027485853	MIF/MAOB/ALDH3B2	0.657317287486554
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1237	51/9376	1.18896127569864	PDIA4/ACTG1/ACTB/KDELR2/ATP6V1B1/SEC61B/KDELR1/ATP6V1C2	0.527495117108754
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/1237	87/9376	1.13258811176465	BIRC5/GRB2/RAC3/RALB/MYC/TGFB1/CTNNB1/AKT1/HRAS/TP53/MAP2K2/AXIN1/MSH2	0.484356011585502
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1237	44/9376	1.20584993018299	RAB11A/DYNLL1/AQP2/CREB3L1/DYNC1LI1/DYNC2LI1/DCTN5	0.533549430878158
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1237	37/9376	1.22912888636413	GPT2/NIT2/ADSL/ASNS/PPAT/ASL	0.544396698072562
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	26/1237	183/9376	1.0768870570877	RAN/FBL/NHP2/NOP56/POP7/RRP7A/NOP58/IMP4/EMG1/RBM28/GNL3/XPO1/RPP30/NOB1/GAR1/GTPBP4/DKC1/TBL3/WDR75/RPP40/NMD3/CSNK2A1/LSG1/RPP25L/MPHOSPH10/WDR43	0.409482283833184
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/1237	110/9376	1.10249136473874	DCN/LRRC32/ID3/ID1/MYC/TGFB1/BMP4/BMP7/GREM2/PPP2R1A/THBS1/TFDP1/PPP2R1B/FMOD/CUL1/E2F5	0.421524123976731
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1237	38/9376	1.19678338935455	GNPNAT1/GPI/NAGK/HK2/GMPPA/PGM1	0.473847140088524
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1237	140/9376	1.08280401893983	CALM3/CALM1/RPS6/MYL4/ACTA2/GNG11/MYL3/CDH1/GNAI1/AKT1/HRAS/TFAM/GNAI3/GNB2/SLC8A3/ADCY5/PLCB3/MAP2K2/PLAT/MAP1LC3A	0.384820709093295
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1237	133/9376	1.08280401893983	CCNB1/BNIP3/GRB2/CCNB2/SKP2/PTEN/TGFB1/IGF1/PRMT1/PLK1/CSNK1E/AKT1/MAPK12/HRAS/CDK2/CCND2/MAP2K2/PLK4/CDKN1B	0.374934775770698
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1237	24/9376	1.2632713554298	HS3ST1/XYLT2/EXTL2/HS3ST3B1	0.503433306958555
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1237	17/9376	1.33758143516097	CTH/SEPHS1/TXNRD1	0.543091813064657
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	23/1237	163/9376	1.06951808005713	BIRC5/CCNE1/GRB2/CCNA2/YWHAQ/MYC/TGFB1/VDAC3/AKT1/STAT5B/MAPK12/HRAS/CREB3L1/CDK2/TP53/E2F1/MAP2K2/MAP2K6/PCNA/TAB1/E2F3/CCNE2/TIRAP	0.349040642733855
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/1237	75/9376	1.11167879277823	MGST1/BIRC5/MGST3/GSTP1/TOP2A/GSTA4/AKT1/TP53/BRCA1/ATP7B/MSH2	0.378548460196013
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1237	46/9376	1.15342167234895	ALAS2/HMBS/ALAD/UROD/MMAB/CP/COX10	0.406639694235884
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	21/1237	150/9376	1.06114793856103	CCNE1/GRB2/CDH1/WNT10B/MYC/TGFB1/CTNNB1/WNT3A/AKT1/WNT2/HRAS/CDK2/FGF7/TP53/E2F1/MAP2K2/LRP6/AXIN1/E2F3/CDKN1B/CCNE2	0.294310454040028
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/1237	166/9376	1.0501894400561	MYL9/CALM3/CALM1/PPP1CA/VDAC1/VDAC2/ATP1B3/SLC25A6/GNAI1/ATP2B4/SLC25A5/VDAC3/AKT1/NPPC/NPR1/GNAI3/CREB3L1/SLC8A3/ADCY5/PLCB3/PPP1CB/MAP2K2/SLC25A4	0.254344027005824
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/1237	77/9376	1.08280401893983	GRB2/MYC/TGFB1/AKT1/STAT5B/HRAS/TP53/E2F1/MAP2K2/E2F3/CDKN1B	0.28442228328434
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1237	122/9376	1.05617769060525	LEP/PFKP/SCD/CCNA2/CPT1C/EIF4EBP1/CAB39L/IGF1/PPARG/AKT1/PFKM/GYS1/PPP2R1A/CREB3L1/RAB10/PPP2R1B/STRADB	0.243480403867535
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/1237	184/9376	1.02984077888299	MYL9/CFL1/MYL12A/CDC42/RAC3/ENAH/EPHB4/GNAI1/SEMA6A/BMP7/CXCL12/ROBO1/PAK4/EPHA2/CFL2/HRAS/PRKCZ/SLIT2/GNAI3/FES/EFNA3/FYN/BOC/SEMA4B/EFNA4	0.159367229232013
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1237	34/9376	1.11465119596747	RORB/CSNK1E/NPAS2/RORA/CUL1	0.261085696743335
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/1237	117/9376	1.03653034291676	ACTG1/ACTB/RUVBL1/SMARCA2/INO80C/RUVBL2/ACTR6/MCRS1/DPF3/INO80B/MTA3/ACTL6A/CECR2/SMARCA5/CHRAC1/ACTR8	0.15500638988813
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/1237	125/9376	1.03082942603072	RAC3/ORMDL2/GNAI1/PTEN/AKT1/CERS5/PPP2R1A/MAPK12/HRAS/PRKCZ/GNAI3/PLCB3/FYN/TP53/PPP2R1B/MAP2K2/S1PR3	0.135272983630348
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	20/1237	148/9376	1.02427407197011	GRB2/WNT10B/PTEN/HEY1/MYC/FLT4/CTNNB1/IGF1/WNT3A/AKT1/WNT2/HRAS/FGF7/TP53/E2F1/MAP2K2/BRCA1/LRP6/AXIN1/E2F3	0.116039183373591
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/1237	80/9376	1.04219886822959	GRB2/RPS6/EIF4EBP1/PTEN/IGF1/PDGFRA/AKT1/HRAS/FGFR3/PDGFRB/MAP2K2	0.147768785233014
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/1237	103/9376	1.03024071704955	COL1A1/COL3A1/COL1A2/LAMA4/ACTN1/ACTN4/ARG2/TGFB1/LAMA2/PLCB3/LAMC3/VCL/LAMA1/COL4A5	0.120305513435913
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1237	126/9376	1.02264824010984	COL1A1/COL3A1/COL1A2/ACTG1/ACTB/PPP1CA/MYL12A/TLN1/GNAI1/AKT1/MAPK12/PRKCZ/GNAI3/ADCY5/PLCB3/FYN/PPP1CB	0.0997777785534569
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1237	28/9376	1.08280401893983	B4GALT1/ST3GAL4/B4GALT4/B3GALNT1	0.171062984029438
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1237	36/9376	1.05272612952484	GALNT2/GALNT1/ST3GAL1/C1GALT1C1/GCNT1	0.123563063782293
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1237	75/9376	1.01061708434384	HSPA5/CGA/PDIA4/HSP90B1/ATP1B3/LRP2/CREB3L1/TTR/ADCY5/PLCB3	0.0359878615281412
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1237	52/9376	1.02033455630869	PLTP/VDAC1/VDAC2/VDAC3/LRP2/LRPAP1/VAPB	0.0573218507339189
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1237	60/9376	1.01061708434384	GNAI1/IGF1/PPP2R1A/HRAS/GNAI3/PLCB3/PPP2R1B/MAP2K2	0.0321625975547525
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1237	37/9376	1.02427407197011	ADH5/MIF/MAOB/ALDH3B2/GSTZ1	0.0576737609953862
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1237	37/9376	1.02427407197011	HBA2/HBA1/LAMA4/THOP1/PLCB3	0.0576737609953862
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/1237	68/9376	1.00318607637073	GRB2/CCNA2/EIF4EBP1/MYC/RUNX1T1/AKT1/STAT5B/HRAS/MAP2K2	0.0102793916807664
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1237	99/9376	0.995304704278027	MMP2/GRB2/IGF1/AKT1/MAPK12/HRAS/ADCY5/TP53/E2F1/MAP2K2/CDKN2C/E2F3/CDKN1B	-0.0183088781030135
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1237	76/9376	0.997319491128792	CALM3/CALM1/ACTG1/ACTB/ATP1B3/GAST/GNAI1/GNAI3/ADCY5/PLCB3	-0.00914676527878092
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1237	61/9376	0.994049591157878	SLC6A19/ATP1B3/ATP2B4/SLC8A3/SLC40A1/MT1A/SLC39A4/ATP7B	-0.0181762906209445
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1237	139/9376	0.981534578319559	MMP2/CALM3/GRB2/HSP90B1/CALM1/HSP90AB1/GNAI1/AKT1/HRAS/GREB1/GNAI3/CREB3L1/ADCY5/PLCB3/TFF1/KRT23/MAP2K2/PRKCD	-0.0855039389102089
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/1237	77/9376	0.984367289945301	RALBP1/CDC42/RAC3/RALB/TGFB1/RAD51/AKT1/TP53/E2F1/E2F3	-0.05369656140616
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1237	38/9376	0.997319491128792	NNMT/PNP/ENPP1/NT5M/NT5C	-0.00645456644877356
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/1237	155/9376	0.978016533235977	CYBA/HLA-C/HLA-G/TUBB/TUBA1B/TUBB6/C1R/CALR/TUBA1C/TUBB4B/ACTG1/ACTB/ATP6V1B1/SEC61B/COLEC11/ATP6V1C2/EEA1/THBS1/DYNC1LI1/COLEC12	-0.10758655046627
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1237	101/9376	0.975595700232917	CALM3/CALM1/WNT10B/GNAI1/CTNNB1/WNT3A/WNT2/HRAS/GNAI3/CREB3L1/ADCY5/PLCB3/MAP2K2	-0.096129136784715
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1237	78/9376	0.971747196484464	CALM3/C1R/CALM1/CFL1/C1S/GNAI1/CFL2/MAPK12/GNAI3/TIRAP	-0.0976785138614508
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/1237	156/9376	0.971747196484464	CLDN6/CLDN10/GRB2/YWHAE/EIF3E/YWHAQ/MYC/CTNNB1/AKT1/EIF2S1/CLDN7/PPP2R1A/HRAS/CLDN3/CDK2/TP53/PPP2R1B/E2F1/MAP2K2/E2F3	-0.138721364376974
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/1237	86/9376	0.969487319283337	GRB2/EIF4EBP1/CBLB/MYC/PAK4/AKT1/STAT5B/HRAS/MAP2K2/CDKN1B/NRG4	-0.110817078617881
NA	NA	hsa04981	Folate transport and metabolism	4/1237	31/9376	0.978016533235977	ABCG2/TYMS/DHFR/MTHFD1	-0.0477938855215559
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1237	23/9376	0.988647147727672	GPT2/ARG2/ASL	-0.0212509525358544
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1237	23/9376	0.988647147727672	REN/ENPEP/THOP1	-0.0212509525358544
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/1237	71/9376	0.960797932298724	CGA/GRB2/AKT1/STAT5B/MAPK12/HRAS/LHB/CCND2/MAP2K2	-0.129260229822755
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1237	15/9376	1.01061708434384	ST3GAL1/SLC33A1	0.0160425993739723
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1237	48/9376	0.947453516572352	CLDN6/CLDN10/EPCAM/CLDN7/CLDN3/CHMP4A	-0.14228364120747
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/1237	73/9376	0.934474701276841	GRB2/AKT1/STAT5B/HRAS/TP53/RET/E2F1/MAP2K2/E2F3	-0.219100764475956
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1237	16/9376	0.947453516572352	ST3GAL1/B3GALNT1	-0.0820069552526411
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/1237	137/9376	0.940537797473284	BIRC5/LMNB2/TUBA1B/TUBA1C/ACTG1/ACTB/LMNB1/CTSV/PARP1/CASP6/DFFA/AKT1/EIF2S1/HRAS/CAPN1/TP53/MAP2K2	-0.273321474882449
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1237	98/9376	0.928117730519855	CALM3/CALM1/IMPA2/PLCD4/PTEN/ITPKB/SYNJ1/PIK3C2G/INPP4B/PLCB3/PLCD1/IPPK	-0.278864093265693
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/1237	138/9376	0.933722306187246	PYGL/CALM3/GRB2/CALM1/RPS6/PPP1CA/EIF4EBP1/CBLB/SH2B2/AKT1/GYS1/HK2/HRAS/PRKCZ/PPP1R3B/PPP1CB/MAP2K2	-0.305775662920147
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	12/1237	99/9376	0.918742803948948	CALM3/CALM1/PPP1CA/IGF1/MAPK12/ADCY5/PLCB3/PPP1CB/CYP2J2/MAP2K6/ASIC1/PRKCD	-0.316855036527108
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	28/1237	227/9376	0.934932104459061	HLA-C/HLA-G/CALM3/CALR/PDIA3/GRB2/CALM1/GNG11/RAC3/EIF4EBP1/GNAI1/MYC/CTNNB1/CXCL12/PDGFRA/AKT1/MAPK12/HRAS/GNAI3/GNB2/CREB3L1/ADCY5/PLCB3/TP53/E2F1/MAP2K2/MAP2K6/E2F3	-0.386881389848178
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1237	43/9376	0.881352108439398	PLA2G2A/ACAT2/AGPAT2/ACAT1/PLA2G10	-0.30399650009552
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/1237	133/9376	0.911834963317753	CALM3/CALM1/PPP1CA/GNG11/GNAI1/AKT1/MAOB/PPP2R1A/MAPK12/GNAI3/GNB2/CREB3L1/ADCY5/PLCB3/PPP2R1B/PPP1CB	-0.399209346146515
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/1237	109/9376	0.903992346087382	PYGL/PPP1CA/SLC2A1/PTEN/SLC27A6/SLC27A2/AKT1/GYS1/PRKCZ/CREB3L1/PPP1R3B/PPP1CB/PRKCD	-0.393037952250822
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1237	69/9376	0.87879746464682	GRB2/RAC3/AKT1/MAPK12/HRAS/FYN/MAP2K2/MAP2K6	-0.393927551650254
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1237	69/9376	0.87879746464682	CALM3/CALM1/REN/GNAI1/NPR1/GNAI3/ADCY5/PLCB3	-0.393927551650254
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/1237	217/9376	0.908158209433407	MGST1/KPNA2/BIRC5/GRB2/HSP90B1/MGST3/HSP90AB1/GSTA4/PTGES3/EIF4EBP1/CCND3/CDC6/GNAI1/MYC/KPNB1/AKT1/STAT5B/HRAS/GNAI3/CREB3L1/FGF7/ADCY5/PAQR7/E2F1/CDC25A/MAP2K2	-0.533618826480757
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1237	19/9376	0.797855592903034	HYAL3/IDUA	-0.343839035053325
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/1237	88/9376	0.861321378702139	PROCR/C1R/TFPI/CD55/C1S/CFD/PLAT/PROS1/F10/F3	-0.50953581044657
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/1237	63/9376	0.842180903619869	WNT10B/BMP4/CTNNB1/WNT3A/WNT2/TP53/AXIN1	-0.489970563753394
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/1237	154/9376	0.885930560950771	MYL9/CALM3/CALM1/ACTG1/MYL6/ACTB/PPP1CA/MYL6B/GNAI1/HRAS/NPR1/GNAI3/ADCY5/PLCB3/PPP1CB/MAP2K2/MAPK7/TRPM2	-0.556419153371835
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/1237	122/9376	0.869793392263143	GRB2/GNAI1/IGF1/AKT1/STAT5B/MAPK12/HRAS/GNAI3/CREB3L1/ADCY5/PLCB3/MAP2K2/MAP2K6/GHR	-0.564330023118313
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1237	38/9376	0.797855592903034	ATP1B3/IGF1/SFN/HSD11B2	-0.486756272986071
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1237	10/9376	0.757962813257882	SELENBP1	-0.298531376482405
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/1237	98/9376	0.850774586309867	CFL1/MYO10/CDC42/ARPC3/ACTR3/ARPC5/ARPC1A/AKT1/CFL2/PRKCD/ACTR3B	-0.578913409132015
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1237	20/9376	0.757962813257882	CMAS/GMPPA	-0.422412684887856
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/1237	73/9376	0.830644178912747	RAN/MAP1B/PSIP1/MAP1A/CHMP4A/XPO1/NELFB/TRIM5	-0.566284940194489
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1237	56/9376	0.812103014204874	CSNK1E/LRP2/CCND2/BOC/CUL1/DISP1	-0.549782402009451
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1237	82/9376	0.831910404795236	HLA-C/HSPA2/HLA-G/HSPA5/CALR/PDIA3/HSP90AB1/HSPA4/NFYB	-0.59597959017058
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1237	65/9376	0.81626764504695	CGA/AKT1/HRAS/LHB/PLCB3/MAP2K2/HCN2	-0.579467549599015
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1237	30/9376	0.757962813257882	PLA2G2A/PLA2G10/CYP2J2	-0.517624470398653
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1237	49/9376	0.77343144209988	GNAI1/MAOB/GNAI3/CREB3L1/ADCY5	-0.619885754207909
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1237	31/9376	0.733512399926983	ALDH7A1/ALDH2/ALDH1B1	-0.579366211322396
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/1237	67/9376	0.791901446687339	CALM3/CALM1/PPP1CA/HRAS/PLCB3/PPP1CB/MAP2K2	-0.666407553504693
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1237	201/9376	0.867320632086134	MYCN/CCNA2/MMP3/MYC/ETV4/IGF1/PPARG/TLX3/ZEB1/RUNX1T1/MLF1/HOXA10/PBX1/CCND2/TP53/TAF15/LMO2/ETV5/CDKN2C/PLAT/MEIS1/PRCC/CDKN1B	-0.741281821275156
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/1237	250/9376	0.879236863379143	HLA-C/HLA-G/CAV1/RAB11A/CDC42/ARPC3/ACTR3/ARPC5/ARPC1A/CBLB/SNX6/SNX2/CHMP2A/CAPZB/SNF8/PDGFRA/EHD2/VPS29/HRAS/PRKCZ/CHMP4A/FGFR4/FGFR3/EEA1/RAB10/ARF5/GRK5/ACTR3B/PSD3	-0.754482412385963
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1237	59/9376	0.770809640601236	CGA/GNAI1/AKT1/NPR1/GNAI3/ADCY5	-0.688445027539976
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/1237	120/9376	0.821126381029372	CALM3/GRB2/CALM1/YWHAE/CDC42/SH2B2/AKT1/MAPK12/HRAS/TP53/MAP2K2/MAPK7/PRKCD	-0.768794393513866
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/1237	60/9376	0.757962813257882	CDC42/RAC3/AKT1/MAPK12/HRAS/MAP2K2	-0.733209267098441
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/1237	69/9376	0.768947781565967	CALM3/CALM1/PPP1CA/MAOB/CREB3L1/ADCY5/PPP1CB	-0.750956524513741
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/1237	138/9376	0.823872623106393	ACTG1/ACTB/CDC42/ARPC3/ACTR3/RAC3/ARPC5/ARPC1A/AKT1/ELMO1/MAPK12/MAP2K2/MAP2K6/TAB1/ACTR3B	-0.81257301408495
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1237	23/9376	0.659098098485115	B4GALT1/CHST10	-0.638120707880037
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1237	23/9376	0.659098098485115	ATP1B3/MDH1	-0.638120707880037
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	27/1237	238/9376	0.859873779746337	PGF/CALM3/ANGPT4/PLA2G2A/RALBP1/GRB2/CALM1/GNG11/CDC42/RAC3/RALB/FLT4/IGF1/PAK4/PDGFRA/EPHA2/AKT1/HRAS/GNB2/FGFR4/FGFR3/EFNA3/PLA2G10/FGF7/PDGFRB/MAP2K2/EFNA4	-0.853625289482741
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1237	53/9376	0.715059257790455	RAB11A/ATP1B3/ATP2B4/SLC8A3/PLCB3	-0.810960325262893
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/1237	115/9376	0.790917718182138	MMP15/GCM1/NACA/PDE4D/GNAI1/MMP14/GNAI3/CREB3L1/ADCY5/PLCB3/OXSR1/LRP6	-0.87947231533019
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/1237	98/9376	0.77343144209988	CALM3/CALM1/CYP11A1/ATP1B3/ATP2B4/HSD3B1/NPR1/CREB3L1/ADCY5/PLCB3	-0.878962724998337
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1237	63/9376	0.721869345959887	PTGDS/PLA2G2A/PTGES3/CBR1/PLA2G10/CYP2J2	-0.863493940105278
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1237	73/9376	0.726813656548654	MGST1/ADH5/MGST3/GSTP1/GSTA4/MAOB/ALDH3B2	-0.913469115913023
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/1237	187/9376	0.810655415249072	CYBA/CASP4/TXN2/YWHAE/VDAC1/TRIP6/VDAC2/SUGT1/HSP90AB1/VDAC3/MAPK12/PLCB3/PANX1/BRCC3/TAB1/DNM1L/TRPM2/MAP1LC3A/PRKCD/SHARPIN	-1.01958756494824
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/1237	65/9376	0.699657981468814	ALDH7A1/AKR1B1/AGPAT5/ALDH2/AGPAT2/ALDH1B1	-0.947239007328681
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1237	65/9376	0.699657981468814	CYP11A1/HSD3B1/PBX1/CREB3L1/ADCY5/PLCB3	-0.947239007328681
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1237	26/9376	0.583048317890678	PLA2G2A/PLA2G10	-0.829949299234559
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1237	26/9376	0.583048317890678	AMN/SLC52A3	-0.829949299234559
NA	NA	hsa04519	Cadherin signaling	46/1237	404/9376	0.863026965590658	MYO1B/DSC2/ACTN1/ACTG1/ACTB/DSP/PPP1CA/YWHAE/ACTN4/CDC42/ARPC3/ACTR3/RAC3/ARPC5/ENAH/ARPC1A/CDH1/WNT10B/CDH5/YWHAQ/FLT4/CTNNB1/CDH11/WNT3A/PDGFRA/TMC6/WNT2/TEAD4/MAPK12/HRAS/PCDH10/DSG2/DES/PDGFRB/PPP1CB/KRT23/MAP2K2/PCDH18/TMC5/VCL/LRP6/MPDZ/AXIN1/MYO1E/DSC3/ACTR3B	-1.09715021060511
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1237	47/9376	0.645074734687559	PKM/HK2/PRKCZ/PRKCD	-0.950940319820633
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/1237	112/9376	0.744427763021134	LAMA4/GNAI1/TGFB1/AKT1/MAPK12/LAMA2/GNAI3/LAMC3/MAP2K6/LAMA1/TAB1	-1.06073860781423
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/1237	76/9376	0.698123643790154	PLTP/SCD/DBI/CPT1C/SLC27A6/PPARG/SLC27A2	-1.03009999449126
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/1237	216/9376	0.807090032635708	CYBA/HSPA2/CALM3/HSPA5/HSPD1/HSP90B1/CALM1/CDC42/HSP90AB1/MMP3/CASP6/PPARG/AKT1/EIF2S1/MAPK12/HRAS/PLCB3/TP53/HSPA4/CYP2J2/MAP2K6/TAB1/TIRAP	-1.11819815171918
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1237	48/9376	0.631635677714902	ATP1B3/AKT1/HK2/PLCB3	-0.997444807849288
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1237	68/9376	0.668790717580484	ADH5/ALDH1A3/ALDH1A2/DHRS9/RETSAT/HSD17B6	-1.06859646353042
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1237	28/9376	0.541402009469916	ATP6V1B1/ATP6V1C2	-0.94740740527322
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1237	168/9376	0.766986180082381	PYGL/HMGB1/VDAC1/VDAC2/HSP90AB1/SLC25A6/PARP1/SLC25A5/CHMP2A/VDAC3/STAT5B/CHMP4A/CAPN1/SLC25A4/PGAM5/DNM1L/SHARPIN	-1.18806069681278
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1237	17/9376	0.445860478386989	CA12	-0.891484560873707
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1237	17/9376	0.445860478386989	MYH10	-0.891484560873707
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1237	29/9376	0.522732974660608	CSNK1E/TEAD4	-1.0034812707761
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1237	29/9376	0.522732974660608	CALM3/CALM1	-1.0034812707761
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1237	79/9376	0.671612619342427	MGST1/ADH5/MGST3/GSTP1/GSTA4/CBR1/ALDH3B2	-1.14265086712952
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/1237	71/9376	0.640531954865816	JAM3/ATP6V1B1/CDC42/ATP6V1C2/MAPK12/IGSF5	-1.1852671262661
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/1237	90/9376	0.673744722895895	EIF4EBP1/IGF1/PPARG/AKT1/HRAS/CREB3L1/ADCY5/TP53	-1.21240976007922
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/1237	90/9376	0.673744722895895	PTEN/AKT1/MAPK12/HRAS/MAP2K2/MAP2K6/CSNK2A1/TIRAP	-1.21240976007922
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1237	18/9376	0.421090451809934	MMAB	-0.958385884264089
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/1237	180/9376	0.757962813257882	HLA-C/HLA-G/CALR/PDIA3/SRSF9/ALYREF/PPP1CA/SRSF3/EIF4EBP1/SRSF7/EIF2B2/AKT1/EIF2S1/SRSF2/TP53/PPP1CB/EIF2B5/TAB1	-1.27821476944934
Human Diseases	Infectious disease: viral	hsa05162	Measles	13/1237	136/9376	0.724523277378858	CCNE1/EIF3H/CBLB/CCND3/AKT1/EIF2S1/STAT5B/CDK2/CCND2/TP53/CDKN1B/CSNK2A1/CCNE2	-1.26154672310524
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/1237	62/9376	0.611260333272485	IGF1/AKT1/HRAS/ADCY5/CLPB	-1.19721334657948
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/1237	83/9376	0.639245746121105	SLC27A2/IDH2/PECR/PXMP4/ECI2/PEX10/NUDT7	-1.28693763712556
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/1237	83/9376	0.639245746121105	POLR1D/POLR2H/POLR2F/POLR3G/POLR2L/POLR2E/POLR3F	-1.28693763712556
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	19/1237	193/9376	0.746181007870454	CXCL14/GRB2/GNG11/CCR7/CDC42/RAC3/GNAI1/CXCL12/AKT1/STAT5B/ELMO1/HRAS/PRKCZ/GNAI3/GNB2/ADCY5/PLCB3/GRK5/PRKCD	-1.38897823788746
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/1237	103/9376	0.662297603817567	CALR/GNAI1/TGFB1/AKT1/PPP2R1A/MAPK12/GNAI3/PLCB3/PPP2R1B	-1.34346881043525
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/1237	122/9376	0.683409093921041	GRB2/CDC42/CBLB/PAK4/AKT1/PPP2R1A/MAPK12/HRAS/FYN/PPP2R1B/MAP2K2	-1.37214045010416
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1237	44/9376	0.516792827221283	HLA-C/HLA-G/HSPD1	-1.25244109533163
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/1237	196/9376	0.734759869994886	HLA-C/HLA-G/CALM3/CALM1/RPS27A/UBA52/GNG11/MYC/CTNNB1/AKT1/MAPK12/HRAS/GNB2/TP53/E2F1/MAP2K2/MAP2K6/E2F3/MAP1LC3A	-1.46295474189073
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1237	45/9376	0.505308542171921	ABCG2/ABCA7/DEFB1	-1.29676576688385
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/1237	56/9376	0.541402009469916	BNIP3/HSPD1/VCP/SAR1A	-1.34184752205257
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/1237	115/9376	0.659098098485115	GNG11/GNAI1/AKT1/HRAS/GNAI3/GNB2/CREB3L1/ADCY5/PLCB3/FYN	-1.43395117950232
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1237	115/9376	0.659098098485115	APP/GNG11/GNAI1/MAOB/HRAS/GNAI3/GNB2/ADCY5/PLCB3/CYP2J2	-1.43395117950232
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/1237	144/9376	0.684271984191143	ADH5/ALDH7A1/SCD/CPT1C/ALDH2/CTNNB1/AKT1/MAPK12/ALDH1B1/MAP2K6/TAB1/IL17RA/TIRAP	-1.48844034123507
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/1237	97/9376	0.625123969697222	CALM3/CALM1/GNG11/GNAI1/GNAI3/GNB2/ADCY5/PLCB3	-1.44679805391756
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/1237	254/9376	0.746026391001852	CALM3/CALM1/VDAC1/VDAC2/SLC25A6/PLCD4/ITPKB/ATP2B4/SLC25A5/FLT4/VDAC3/TNNC1/PDGFRA/TACR3/FGFR4/FGFR3/SLC8A3/FGF7/PLCB3/PDGFRB/RET/SLN/MST1/PLCD1/SLC25A4	-1.59972517182343
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/1237	99/9376	0.612495202632632	GRB2/RAC3/EIF4EBP1/PDGFRA/AKT1/HRAS/PDGFRB/MAP2K2	-1.51103967022348
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1237	70/9376	0.541402009469916	MGST1/MGST3/GSTP1/GSTA4/CBR1	-1.50135919145327
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1237	91/9376	0.583048317890678	PDE4D/GNG11/GNAI1/GNAI3/GNB2/ADCY5/GRK5	-1.55811832794092
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1237	195/9376	0.699657981468814	CYBA/CASP4/HMGB1/ACTG1/ACTB/VDAC1/VDAC2/SLC25A6/SLC25A5/VDAC3/AKT1/MAPK12/PLCB3/MAP2K2/HDAC8/CLCN3/SLC25A4/HDAC3	-1.6522409091165
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/1237	323/9376	0.750922910967561	CCNE1/GRB2/STMN1/IGF2BP1/PTEN/MYC/PAK4/ZEB1/WNT3A/PDGFRA/TNXB/CDCA5/KIF23/HRAS/EZH2/CCND2/FGFR3/EFNA3/THBS1/TP53/PDGFRB/CDC25C/RDX/E2F1/CDC25A/MAP2K2/BRCA1/MAPK7/E2F3/CDKN1B/EFNA4/CCNE2	-1.7759214232071
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1237	51/9376	0.445860478386989	PLA2G2A/PLA2G10/PAFAH1B3	-1.54690896728504
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1237	39/9376	0.388698878593786	HLA-C/HLA-G	-1.49131291993424
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/1237	94/9376	0.564440392851614	HSP90B1/HSP90AB1/MMP3/TRAF4/MAPK12/MAPK7/IL17RA	-1.65453403731348
NA	NA	hsa04081	Hormone signaling	20/1237	219/9376	0.692203482427289	LEP/CGA/GNG11/RAMP1/GAST/RAMP2/GNAI1/IGF1/STAT5B/NPPC/NPR1/GNAI3/GNB2/LHB/EPO/SLC40A1/ADCY5/PLCB3/GHR/SLC16A2	-1.7967767365034
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/1237	173/9376	0.657193190686025	KPNA2/RAB11A/ACTG1/ACTB/VDAC1/FDPS/DNAJC3/SLC25A6/CCND3/SLC25A5/AKT1/EIF2S1/XPO1/MAP2K2/SLC25A4	-1.77415983971847
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	29/1237	300/9376	0.732697386149286	PGF/ANGPT4/GRB2/STMN1/CDC42/RAC3/MYC/TGFB1/FLT4/IGF1/PDGFRA/EPHA2/AKT1/MAPK12/HRAS/FGFR4/FGFR3/EFNA3/MAP4K4/FGF7/TP53/PDGFRB/RET/MAP2K2/MAP2K6/DUSP5/MAPK7/TAB1/EFNA4	-1.83443172732183
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1237	86/9376	0.528811265063639	SLC2A1/ATP1B3/CREB3L1/ADCY5/PLCB3/TRPM4	-1.71128061700552
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1237	54/9376	0.421090451809934	HLA-C/HLA-G/CGA	-1.66317522490907
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/1237	119/9376	0.573249186497558	MMP3/MMP14/AKT1/MAPK12/CREB3L1/MAP2K6/PGAM5/TAB1/DNM1L	-1.82640745118908
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1237	168/9376	0.631635677714902	LEP/LIFR/GRB2/CCND3/MYC/PDGFRA/AKT1/STAT5B/HRAS/CCND2/EPO/PDGFRB/CNTFR/GHR	-1.87816831452198
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/1237	149/9376	0.610439849603663	GRB2/RALB/AGPAT5/AGPAT2/PDGFRA/AKT1/HRAS/ADCY5/PLCB3/FYN/PDGFRB/MAP2K2	-1.8686258932514
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/1237	89/9376	0.510986166241269	GNG11/GNAI1/GNAI3/GNB2/SLC38A5/ADCY5	-1.80702178949346
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	20/1237	226/9376	0.670763551555648	MYL9/CALM3/CGA/CALM1/PDE4D/PPP1CA/ATP1B3/RAC3/GNAI1/ATP2B4/HCAR3/AKT1/NPR1/GNAI3/LHB/CREB3L1/ADCY5/PPP1CB/MAP2K2/HCN2	-1.95315425694168
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/1237	91/9376	0.499755701049153	GRB2/IFITM1/RAC3/AKT1/HRAS/MAP2K2	-1.86937682251372
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1237	30/9376	0.252654271085961	PIGK	-1.5982851327139
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/1237	102/9376	0.520170558118154	PLA2G2A/RAB11A/ATP1B3/ATP2B4/PLA2G10/ADCY5/PLCB3	-1.89949605632952
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1237	45/9376	0.336872361447948	HLA-C/HLA-G	-1.7382980990298
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/1237	70/9376	0.433121607575933	LEP/SLC2A1/CPT1C/AKT1	-1.85584782854886
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/1237	93/9376	0.489008266617988	CALM3/CALM1/ATP1B3/ATP2B4/ADCY5/PLCB3	-1.93061704949813
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/1237	83/9376	0.456604104372218	AURKB/WDR5/CBX3/EZH2/TFDP1	-1.93848477855429
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/1237	32/9376	0.236863379143088	MLST8	-1.68576034200404
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/1237	32/9376	0.236863379143088	BIRC5	-1.68576034200404
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/1237	105/9376	0.505308542171921	CALM3/CALM1/CBLB/AKT1/MAPK12/HRAS/PRKCD	-1.98724189299162
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/1237	33/9376	0.229685700987237	STX2	-1.72809143958342
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/1237	169/9376	0.583048317890678	BNIP3/HMGB1/RPS27A/UBA52/PTEN/AKT1/EIF2S1/HRAS/MLST8/MAP2K2/NRBF2/MAP1LC3A/PRKCD	-2.13233273805313
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/1237	160/9376	0.568472109943411	JAM3/HLA-C/HLA-G/CLDN6/CLDN10/CDH1/CDH5/VCAN/CLDN7/CNTNAP2/CLDN3/SDC1	-2.1462612859769
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1237	50/9376	0.303185125303153	TGFB1/CXCL12	-1.92592634170852
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1237	191/9376	0.595258753867447	CALM3/GRB2/CALM1/PPP1CA/GNG11/GNAI1/MAOB/HRAS/GNAI3/GNB2/CREB3L1/ADCY5/PPP1CB/HDAC8/HDAC3	-2.20312699302691
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1237	36/9376	0.210545225904967	AKR1B1	-1.85007796862449
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/1237	78/9376	0.388698878593786	CYBA/TGFB1/MAPK12/TAB1	-2.11345344995454
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/1237	79/9376	0.383778639624244	ATP6V1B1/SLC1A2/ATP6V1C2/STX2	-2.14419284433867
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/1237	38/9376	0.199463898225758	ADA	-1.92766139259797
NA	NA	hsa04382	Cornified envelope formation	17/1237	217/9376	0.593795752321843	PADI1/CLDN6/CLDN10/S100A11/DSP/TCHH/CLDN7/PPP2R1A/CLDN3/BLMH/DSG2/CAPN1/PPP2R1B/KRT23/CASP14/S100A16/COL4A5	-2.36012639366334
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/1237	104/9376	0.437286238418009	PLA2G2A/AGPAT5/AGPAT2/PHOSPHO1/PLA2G10/PTDSS1	-2.24958526263932
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1237	116/9376	0.457391352828032	GNG11/GNAI1/SLC1A2/GNAI3/GNB2/ADCY5/PLCB3	-2.2924252088711
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/1237	95/9376	0.398927796451517	ATP6V1B1/MMP3/TGFB1/CXCL12/ATP6V1C2	-2.29549327442486
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/1237	142/9376	0.480398966149362	CYBA/GRB2/TGFB1/PPARG/AKT1/MAPK12/FYN/MAP2K6/TAB1	-2.43222757199286
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/1237	109/9376	0.417227236655715	AKT1/MAPK12/MAP2K2/MAP2K6/TAB1/TIRAP	-2.38576617798477
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1237	99/9376	0.382809501645395	C1R/C1S/CFD/DEFB1/KRT23	-2.40667814549577
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/1237	62/9376	0.244504133308994	HEY1/MAML3	-2.32672354355364
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1237	90/9376	0.336872361447948	ABCG2/SLC2A1/ATP1B3/ADCY5	-2.46427407487497
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/1237	105/9376	0.360934672979944	PARP1/CXCL12/TAB1/CSNK2A1/TIRAP	-2.5672110769578
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/1237	66/9376	0.229685700987237	TGFB1/RORA	-2.44821779673813
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1237	143/9376	0.42403514028413	C1R/SSB/ACTN1/SNRPD1/SNRPB/SNRPD3/ACTN4/C1S	-2.7056869822404
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/1237	133/9376	0.398927796451517	HLA-C/HLA-G/GRB2/RAC3/HRAS/FYN/MAP2K2	-2.72164171189815
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/1237	109/9376	0.347689363879762	HSP90AB1/TGFB1/STAT5B/MAPK12/RORA	-2.67044163880391
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/1237	100/9376	0.303185125303153	GYPA/CD55/CD7/EPO	-2.73100192740125
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/1237	72/9376	0.210545225904967	MAPK12/DHX58	-2.62146230091551
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/1237	55/9376	0.137811420592342	CERS5	-2.49998452513029
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/1237	93/9376	0.244504133308994	STAT5B/MAPK12/MAML3	-2.85439686353714
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/1237	181/9376	0.418763985225349	CALM3/HSPD1/CALM1/TGFB1/AKT1/MAPK12/EEA1/NFYB/HSPA9/TIRAP	-3.07822882602885
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/1237	250/9376	0.485096200485044	LAPTM4B/ATP6V1B1/CTSV/CTSE/HYAL3/IDUA/VPS29/ATP6V1C2/AP1M2/OSBPL6/MLST8/LAMTOR2/BLOC1S5/AP1S3/AP3D1/KXD1	-3.21692423429193
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1237	100/9376	0.227388843977365	CXCL14/CCR7/CXCL12	-3.0280676157315
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1237	86/9376	0.0881352108439398	PLCB3	-3.31174415539316
NA	NA	hsa04082	Neuroactive ligand signaling	8/1237	199/9376	0.304708668646385	GNG11/GNAI1/SLC1A2/TACR3/GNAI3/GNB2/ADCY5/PLCB3	-3.86480824440394
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/1237	298/9376	0.38152490600229	LEP/LIFR/CXCL14/CCR7/TGFB1/BMP4/BMP7/CXCL12/ACVRL1/GDF11/EPO/IL36RN/CNTFR/GHR/IL17RA	-4.22980378873784
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1237	370/9376	0.266311258712229	LEP/CGA/GAL/TMEM97/NPW/TACR3/GZMA/NMB/CHRNA5/RLN2/LHB/GHR/S1PR3	-5.61347391932945
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1237	449/9376	0.0506433950951814	CALM3/CALM1/SLC8A3	-8.03682928128672