ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 108/2209 175/18639 0.617142857142857 5.20730000646705 6.94856616165862e-56 8.5814792096484e-53 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 35/2209 68/18639 0.514705882352941 4.34296194711474 1.55986311538322e-15 9.63215473749138e-13 GO:0009055 electron transfer activity 46/2209 116/18639 0.396551724137931 3.34600615038791 1.78436467030112e-14 7.34563455940627e-12 GO:0045296 cadherin binding 85/2209 334/18639 0.254491017964072 2.14733276769232 3.83025638421343e-12 1.1825916586259e-09 GO:0019843 rRNA binding 30/2209 65/18639 0.461538461538462 3.89434829543476 6.17815159313915e-12 1.52600344350537e-09 GO:0003954 NADH dehydrogenase activity 24/2209 44/18639 0.545454545454545 4.60241162187744 8.54266741703925e-12 1.75836571000725e-09 GO:0008137 NADH dehydrogenase (ubiquinone) activity 23/2209 41/18639 0.560975609756098 4.73337455420729 1.06322769388355e-11 1.8758374313517e-09 GO:0051082 unfolded protein binding 42/2209 121/18639 0.347107438016529 2.92880739574019 4.13587496385743e-11 6.38475697545491e-09 GO:0022853 active monoatomic ion transmembrane transporter activity 41/2209 118/18639 0.347457627118644 2.93176220546148 6.78336242440095e-11 9.30828066015019e-09 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 25/2209 58/18639 0.431034482758621 3.63696320694338 2.10342542321348e-09 2.59773039766865e-07 GO:0030515 snoRNA binding 17/2209 32/18639 0.53125 4.48255715255772 1.6497822254306e-08 1.85225549855162e-06 GO:0016887 ATP hydrolysis activity 88/2209 417/18639 0.211031175059952 1.78062927656969 3.930229294782e-08 4.04486098254648e-06 GO:0015399 primary active transmembrane transporter activity 45/2209 166/18639 0.271084337349398 2.28734312533066 5.94135591799151e-08 5.64428812209194e-06 GO:0044183 protein folding chaperone 26/2209 75/18639 0.346666666666667 2.92508827523766 2.11801868218144e-07 1.84912052783932e-05 GO:0016860 intramolecular oxidoreductase activity 21/2209 53/18639 0.39622641509434 3.34326127249588 2.33387605119462e-07 1.84912052783932e-05 GO:0031625 ubiquitin protein ligase binding 67/2209 302/18639 0.221854304635762 1.87195218836847 2.39562173647199e-07 1.84912052783932e-05 GO:0016853 isomerase activity 46/2209 180/18639 0.255555555555556 2.15631507469443 2.83790202992178e-07 2.02273525471327e-05 GO:0044389 ubiquitin-like protein ligase binding 70/2209 322/18639 0.217391304347826 1.83429448698014 2.9481161607157e-07 2.02273525471327e-05 GO:0003697 single-stranded DNA binding 35/2209 121/18639 0.289256198347107 2.44067282978349 3.14770329064802e-07 2.04600713892121e-05 GO:0055105 ubiquitin-protein transferase inhibitor activity 10/2209 15/18639 0.666666666666667 5.62516976007243 9.15131017144967e-07 5.65093403087017e-05 GO:0140662 ATP-dependent protein folding chaperone 17/2209 40/18639 0.425 3.58604572204617 1.01512704653982e-06 5.70865077683281e-05 GO:0055106 ubiquitin-protein transferase regulator activity 16/2209 36/18639 0.444444444444444 3.75011317338162 1.01692564445605e-06 5.70865077683281e-05 GO:0043021 ribonucleoprotein complex binding 44/2209 177/18639 0.248587570621469 2.09752092748464 1.15571078529158e-06 6.20566443406565e-05 GO:0031720 haptoglobin binding 8/2209 10/18639 0.8 6.75020371208692 1.38754561908062e-06 6.95872343422066e-05 GO:0140104 molecular carrier activity 56/2209 249/18639 0.224899598393574 1.89764762990395 1.44609671698532e-06 6.95872343422066e-05 GO:0051540 metal cluster binding 25/2209 77/18639 0.324675324675325 2.739530727308 1.46499440720435e-06 6.95872343422066e-05 GO:0008135 translation factor activity, RNA binding 26/2209 83/18639 0.313253012048193 2.64315205593765 1.95614651333858e-06 8.65956844661488e-05 GO:0016651 oxidoreductase activity, acting on NAD(P)H 27/2209 88/18639 0.306818181818182 2.58885653730606 1.96330296765358e-06 8.65956844661488e-05 GO:0180051 translation factor activity 26/2209 84/18639 0.30952380952381 2.61168596003363 2.51630920194165e-06 0.000107160064289584 GO:0003743 translation initiation factor activity 19/2209 51/18639 0.372549019607843 3.14347721886401 2.62375212567503e-06 0.000108011129173622 GO:0015078 proton transmembrane transporter activity 44/2209 185/18639 0.237837837837838 2.00681731980962 4.0797143664479e-06 0.000158137910175421 GO:0051536 iron-sulfur cluster binding 24/2209 76/18639 0.315789473684211 2.66455409687641 4.09750050656962e-06 0.000158137910175421 GO:1990948 ubiquitin ligase inhibitor activity 8/2209 11/18639 0.727272727272727 6.13654882916993 4.55494130855359e-06 0.000170465227759506 GO:0048027 mRNA 5'-UTR binding 12/2209 24/18639 0.5 4.21887732005432 5.10062347480582e-06 0.000185272646805447 GO:0051087 protein-folding chaperone binding 34/2209 134/18639 0.253731343283582 2.14092281913204 1.14186190508274e-05 0.000402914129364909 GO:0004601 peroxidase activity 19/2209 57/18639 0.333333333333333 2.81258488003622 1.70882965124783e-05 0.000586223505358632 GO:0017069 snRNA binding 18/2209 54/18639 0.333333333333333 2.81258488003622 2.83106190570905e-05 0.000944962555013697 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 19/2209 59/18639 0.322033898305085 2.717243019696 2.96744422012395e-05 0.000964419371540285 GO:0070182 DNA polymerase binding 10/2209 21/18639 0.476190476190476 4.01797840005174 5.46932980007497e-05 0.00173195443669041 GO:0005344 oxygen carrier activity 8/2209 14/18639 0.571428571428571 4.82157408006208 5.95528694687973e-05 0.00183869484484912 GO:0015035 protein-disulfide reductase activity 13/2209 34/18639 0.382352941176471 3.22620030357095 7.29093664275496e-05 0.00219617237897619 GO:0140097 catalytic activity, acting on DNA 64/2209 336/18639 0.19047619047619 1.60719136002069 7.851031546224e-05 0.00230857713323491 GO:0098641 cadherin binding involved in cell-cell adhesion 9/2209 18/18639 0.5 4.21887732005432 8.08304465781351e-05 0.00232152561683714 GO:0003678 DNA helicase activity 21/2209 74/18639 0.283783783783784 2.39449793840921 9.42545396061771e-05 0.0025497967303192 GO:0003684 damaged DNA binding 21/2209 74/18639 0.283783783783784 2.39449793840921 9.42545396061771e-05 0.0025497967303192 GO:0015631 tubulin binding 71/2209 385/18639 0.184415584415584 1.55605345311095 9.4972185906626e-05 0.0025497967303192 GO:0019838 growth factor binding 32/2209 136/18639 0.235294117647059 1.98535403296674 9.92887602599352e-05 0.00260897061534085 GO:0008094 ATP-dependent activity, acting on DNA 44/2209 210/18639 0.20952380952381 1.76791049602276 0.000110517735563159 0.0028435292379271 GO:0004129 cytochrome-c oxidase activity 8/2209 15/18639 0.533333333333333 4.50013580805794 0.000114332326195761 0.00288164128268908 GO:0005201 extracellular matrix structural constituent 37/2209 168/18639 0.220238095238095 1.85831501002393 0.00013088768976787 0.00320256403723213 GO:0008017 microtubule binding 54/2209 276/18639 0.195652173913043 1.65086503828213 0.000134967027914656 0.00320256403723213 GO:0003756 protein disulfide isomerase activity 9/2209 19/18639 0.473684210526316 3.99683114531462 0.000137437970828585 0.00320256403723213 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 9/2209 19/18639 0.473684210526316 3.99683114531462 0.000137437970828585 0.00320256403723213 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/2209 16/18639 0.5 4.21887732005432 0.00020490527821603 0.00468625960364439 GO:0001091 RNA polymerase II general transcription initiation factor binding 10/2209 24/18639 0.416666666666667 3.51573110004527 0.000217329987659191 0.00488004608652912 GO:0004386 helicase activity 34/2209 155/18639 0.219354838709677 1.85086230815286 0.000260184859693729 0.00573800538788849 GO:0017116 single-stranded DNA helicase activity 17/2209 58/18639 0.293103448275862 2.4731349807215 0.000279162477069871 0.00604852033651388 GO:0140597 protein carrier chaperone 39/2209 188/18639 0.207446808510638 1.75038527108637 0.000325918027645837 0.00693980627832085 GO:0004029 aldehyde dehydrogenase (NAD+) activity 8/2209 17/18639 0.470588235294118 3.97070806593348 0.000346893526255968 0.00726124584620542 GO:0001094 TFIID-class transcription factor complex binding 6/2209 10/18639 0.6 5.06265278406519 0.000377852205508919 0.00777745789672525 GO:0015036 disulfide oxidoreductase activity 13/2209 40/18639 0.325 2.74227025803531 0.000477240627571664 0.0094941915196768 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 13/2209 40/18639 0.325 2.74227025803531 0.000477240627571664 0.0094941915196768 GO:0051539 4 iron, 4 sulfur cluster binding 14/2209 45/18639 0.311111111111111 2.62507922136713 0.000484319081570557 0.0094941915196768 GO:0043022 ribosome binding 26/2209 112/18639 0.232142857142857 1.95876447002522 0.000533664977157867 0.0102980663560932 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 8/2209 18/18639 0.444444444444444 3.75011317338162 0.000559743989998233 0.0105293908974301 GO:0003727 single-stranded RNA binding 22/2209 89/18639 0.247191011235955 2.08573710204933 0.000562704290874809 0.0105293908974301 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 14/2209 46/18639 0.304347826086957 2.5680122817722 0.000621139465375377 0.0114493617871431 GO:0034511 U3 snoRNA binding 6/2209 11/18639 0.545454545454545 4.60241162187744 0.000747833595723648 0.0131939212959815 GO:0048407 platelet-derived growth factor binding 6/2209 11/18639 0.545454545454545 4.60241162187744 0.000747833595723648 0.0131939212959815 GO:0070990 snRNP binding 6/2209 11/18639 0.545454545454545 4.60241162187744 0.000747833595723648 0.0131939212959815 GO:0017134 fibroblast growth factor binding 9/2209 23/18639 0.391304347826087 3.30173007656425 0.00078106611259509 0.0135861499866892 GO:0140658 ATP-dependent chromatin remodeler activity 33/2209 158/18639 0.208860759493671 1.76231584255434 0.000796873591265526 0.0136685956279573 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 7/2209 15/18639 0.466666666666667 3.9376188320507 0.000880377130203706 0.0147248795661512 GO:0016209 antioxidant activity 21/2209 86/18639 0.244186046511628 2.06038194700327 0.000882300476028495 0.0147248795661512 GO:0004857 enzyme inhibitor activity 71/2209 416/18639 0.170673076923077 1.44009754674931 0.000960059055721267 0.0158089724508769 GO:0036121 double-stranded DNA helicase activity 14/2209 48/18639 0.291666666666667 2.46101177003169 0.000994409230697931 0.0160397733132026 GO:0003689 DNA clamp loader activity 33/2209 160/18639 0.20625 1.74028689452241 0.00100005064381911 0.0160397733132026 GO:0042162 telomeric DNA binding 12/2209 38/18639 0.315789473684211 2.66455409687641 0.00104269517516431 0.0165093402734349 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 15/2209 54/18639 0.277777777777778 2.34382073336351 0.00116005509471761 0.0181350385060285 GO:0000217 DNA secondary structure binding 12/2209 39/18639 0.307692307692308 2.59623219695651 0.00134570670896168 0.020521053140478 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 6/2209 12/18639 0.5 4.21887732005432 0.00134591522621759 0.020521053140478 GO:0022804 active transmembrane transporter activity 76/2209 457/18639 0.166301969365427 1.40321521367234 0.00137330446616868 0.0206677856648778 GO:0003779 actin binding 74/2209 443/18639 0.167042889390519 1.40946691505201 0.0013939544759789 0.0206677856648778 GO:0017070 U6 snRNA binding 7/2209 16/18639 0.4375 3.69151765504753 0.00140574412619412 0.0206677856648778 GO:0051015 actin filament binding 40/2209 209/18639 0.191387559808612 1.61488127083419 0.00144758236251503 0.0207913518869123 GO:0140098 catalytic activity, acting on RNA 66/2209 387/18639 0.170542635658915 1.43899691536737 0.00144781883584976 0.0207913518869123 GO:0005518 collagen binding 18/2209 72/18639 0.25 2.10943866002716 0.00150244951363159 0.0213278752797128 GO:0140713 histone chaperone activity 33/2209 164/18639 0.201219512195122 1.69784087270479 0.00154575953962339 0.0216933299026691 GO:0051117 ATPase binding 20/2209 84/18639 0.238095238095238 2.00898920002587 0.00161225032767928 0.0223722376930776 GO:0004532 RNA exonuclease activity 12/2209 40/18639 0.3 2.53132639203259 0.00171790645812883 0.0235734941754344 GO:0043539 protein serine/threonine kinase activator activity 18/2209 73/18639 0.246575342465753 2.08054224002679 0.00177713864571733 0.024118310191878 GO:0048029 monosaccharide binding 18/2209 74/18639 0.243243243243243 2.05242680435075 0.00209295838655214 0.0280956913846944 GO:0000049 tRNA binding 19/2209 80/18639 0.2375 2.0039667270258 0.0021489260600266 0.0285368138078801 GO:0061749 forked DNA-dependent helicase activity 13/2209 47/18639 0.276595744680851 2.33384702811516 0.00252549284845063 0.0331806773174099 GO:0070034 telomerase RNA binding 8/2209 22/18639 0.363636363636364 3.06827441458496 0.00264683079102702 0.0344088002833513 GO:0031072 heat shock protein binding 27/2209 131/18639 0.206106870229008 1.73907920063308 0.00277173487930789 0.035657214332763 GO:0000510 H3-H4 histone complex chaperone activity 30/2209 151/18639 0.198675496688742 1.67637509406132 0.00300584712193254 0.0371222119558669 GO:0140584 chromatin extrusion motor activity 30/2209 151/18639 0.198675496688742 1.67637509406132 0.00300584712193254 0.0371222119558669 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 30/2209 151/18639 0.198675496688742 1.67637509406132 0.00300584712193254 0.0371222119558669 GO:0140849 ATP-dependent H2AZ histone chaperone activity 30/2209 151/18639 0.198675496688742 1.67637509406132 0.00300584712193254 0.0371222119558669 GO:0009378 four-way junction helicase activity 13/2209 48/18639 0.270833333333333 2.28522521502942 0.00309418104933021 0.0378347880784437 GO:0070628 proteasome binding 7/2209 18/18639 0.388888888888889 3.28134902670892 0.0031569730818843 0.0378530267585156 GO:1990381 ubiquitin-specific protease binding 7/2209 18/18639 0.388888888888889 3.28134902670892 0.0031569730818843 0.0378530267585156 GO:0015616 DNA translocase activity 30/2209 152/18639 0.197368421052632 1.66534631054776 0.00333006872437826 0.0390757127529905 GO:0140674 ATP-dependent histone chaperone activity 30/2209 152/18639 0.197368421052632 1.66534631054776 0.00333006872437826 0.0390757127529905 GO:0032356 oxidized DNA binding 5/2209 10/18639 0.5 4.21887732005432 0.00350506786717417 0.0390757127529905 GO:0047429 nucleoside triphosphate diphosphatase activity 5/2209 10/18639 0.5 4.21887732005432 0.00350506786717417 0.0390757127529905 GO:0097177 mitochondrial ribosome binding 5/2209 10/18639 0.5 4.21887732005432 0.00350506786717417 0.0390757127529905 GO:0005347 ATP transmembrane transporter activity 6/2209 14/18639 0.428571428571429 3.61618056004656 0.00354522550060556 0.0390757127529905 GO:0032036 myosin heavy chain binding 6/2209 14/18639 0.428571428571429 3.61618056004656 0.00354522550060556 0.0390757127529905 GO:0001098 basal transcription machinery binding 15/2209 60/18639 0.25 2.10943866002716 0.00359907689562796 0.0390757127529905 GO:0001099 basal RNA polymerase II transcription machinery binding 15/2209 60/18639 0.25 2.10943866002716 0.00359907689562796 0.0390757127529905 GO:0004714 transmembrane receptor protein tyrosine kinase activity 15/2209 60/18639 0.25 2.10943866002716 0.00359907689562796 0.0390757127529905 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 11/2209 38/18639 0.289473684210526 2.44250792213671 0.00360698886950682 0.0390757127529905 GO:0061775 cohesin loader activity 30/2209 153/18639 0.196078431372549 1.65446169413895 0.00368350790035301 0.0395576717994432 GO:0060590 ATPase regulator activity 13/2209 49/18639 0.26530612244898 2.23858796574311 0.00376286611582623 0.0400615487331499 GO:0097718 disordered domain specific binding 9/2209 28/18639 0.321428571428571 2.71213542003492 0.00381187458271016 0.0402364539286072 GO:0004527 exonuclease activity 19/2209 84/18639 0.226190476190476 1.90853974002457 0.00386234433560799 0.0402423183236827 GO:0016829 lyase activity 37/2209 200/18639 0.185 1.5609846084201 0.00387759990325364 0.0402423183236827 GO:0098632 cell-cell adhesion mediator activity 14/2209 55/18639 0.254545454545455 2.14779209020947 0.00405620837888672 0.0417451445660425 GO:0030020 extracellular matrix structural constituent conferring tensile strength 12/2209 44/18639 0.272727272727273 2.30120581093872 0.00414075193060053 0.0422630465643938 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 10/2209 34/18639 0.294117647058824 2.48169254120843 0.00478741156910298 0.0480687259174161 GO:0019825 oxygen binding 10/2209 34/18639 0.294117647058824 2.48169254120843 0.00478741156910298 0.0480687259174161 GO:0000774 adenyl-nucleotide exchange factor activity 6/2209 15/18639 0.4 3.37510185604346 0.00532179108087346 0.0530033224586994 GO:0005536 D-glucose binding 5/2209 11/18639 0.454545454545455 3.8353430182312 0.00580276309338293 0.0564284442545505 GO:0015217 ADP transmembrane transporter activity 5/2209 11/18639 0.454545454545455 3.8353430182312 0.00580276309338293 0.0564284442545505 GO:0050998 nitric-oxide synthase binding 5/2209 11/18639 0.454545454545455 3.8353430182312 0.00580276309338293 0.0564284442545505 GO:0000175 3'-5'-RNA exonuclease activity 10/2209 35/18639 0.285714285714286 2.41078704003104 0.00600342795789545 0.0579236994375069 GO:0008187 poly-pyrimidine tract binding 9/2209 30/18639 0.3 2.53132639203259 0.00634705920573231 0.0607644815432512 GO:0019887 protein kinase regulator activity 44/2209 255/18639 0.172549019607843 1.45592629084228 0.00664277889252039 0.0631063994789437 GO:0098631 cell adhesion mediator activity 17/2209 76/18639 0.223684210526316 1.88739248528746 0.00683498023123142 0.0644366456913801 GO:0004713 protein tyrosine kinase activity 27/2209 140/18639 0.192857142857143 1.62728125202095 0.00710585281134913 0.0664827895607286 GO:1990518 single-stranded 3'-5' DNA helicase activity 12/2209 47/18639 0.25531914893617 2.15432033364476 0.00733798762803783 0.0681384565460656 GO:0003688 DNA replication origin binding 6/2209 16/18639 0.375 3.16415799004074 0.00767141925368105 0.0688465598663222 GO:0097027 ubiquitin-protein transferase activator activity 6/2209 16/18639 0.375 3.16415799004074 0.00767141925368105 0.0688465598663222 GO:0005003 ephrin receptor activity 13/2209 53/18639 0.245283018867925 2.06963793059269 0.0076929759202854 0.0688465598663222 GO:0005005 transmembrane-ephrin receptor activity 13/2209 53/18639 0.245283018867925 2.06963793059269 0.0076929759202854 0.0688465598663222 GO:0140296 general transcription initiation factor binding 13/2209 53/18639 0.245283018867925 2.06963793059269 0.0076929759202854 0.0688465598663222 GO:0035401 histone H3Y41 kinase activity 23/2209 115/18639 0.2 1.68755092802173 0.00795825798207514 0.0702032043418771 GO:0140801 histone H2AXY142 kinase activity 23/2209 115/18639 0.2 1.68755092802173 0.00795825798207514 0.0702032043418771 GO:0070006 metalloaminopeptidase activity 8/2209 26/18639 0.307692307692308 2.59623219695651 0.00839617879123762 0.0735409986324713 GO:0019207 kinase regulator activity 48/2209 287/18639 0.167247386759582 1.41119241367671 0.00857604151245636 0.074587403294955 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 12/2209 48/18639 0.25 2.10943866002716 0.00875258982094037 0.0750656140893149 GO:0043138 3'-5' DNA helicase activity 12/2209 48/18639 0.25 2.10943866002716 0.00875258982094037 0.0750656140893149 GO:0016423 tRNA (guanine) methyltransferase activity 5/2209 12/18639 0.416666666666667 3.51573110004527 0.00898622585564389 0.0765378547015186 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 14/2209 60/18639 0.233333333333333 1.96880941602535 0.00919514406306066 0.077780841903287 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 11/2209 43/18639 0.255813953488372 2.15849537305105 0.00990416866351401 0.0832084918329238 GO:0016835 carbon-oxygen lyase activity 17/2209 79/18639 0.215189873417722 1.81571935293477 0.0101548725196849 0.0847382943365599 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 14/2209 61/18639 0.229508196721311 1.93653385182821 0.010665121608742 0.0883988267570225 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/2209 22/18639 0.318181818181818 2.68474011276184 0.0110597744224814 0.0904557709388382 GO:0140517 protein-RNA adaptor activity 7/2209 22/18639 0.318181818181818 2.68474011276184 0.0110597744224814 0.0904557709388382 GO:0030145 manganese ion binding 15/2209 68/18639 0.220588235294118 1.86126940590632 0.0121351657212121 0.0979259131274162 GO:0005006 epidermal growth factor receptor activity 12/2209 50/18639 0.24 2.02506111362608 0.0122110045519207 0.0979259131274162 GO:0005007 fibroblast growth factor receptor activity 12/2209 50/18639 0.24 2.02506111362608 0.0122110045519207 0.0979259131274162 GO:0031994 insulin-like growth factor I binding 5/2209 13/18639 0.384615384615385 3.24529024619563 0.0131964053486872 0.103806118507189 GO:0043560 insulin receptor substrate binding 5/2209 13/18639 0.384615384615385 3.24529024619563 0.0131964053486872 0.103806118507189 GO:0045159 myosin II binding 5/2209 13/18639 0.384615384615385 3.24529024619563 0.0131964053486872 0.103806118507189 GO:0000287 magnesium ion binding 39/2209 230/18639 0.169565217391304 1.43074969984451 0.0133576073447354 0.104409146017394 GO:0051537 2 iron, 2 sulfur cluster binding 8/2209 28/18639 0.285714285714286 2.41078704003104 0.0134780824427795 0.104688250420331 GO:0003746 translation elongation factor activity 6/2209 18/18639 0.333333333333333 2.81258488003622 0.0144486711911951 0.11147206963823 GO:0004540 RNA nuclease activity 23/2209 121/18639 0.190082644628099 1.60387071671487 0.0145319864062794 0.11147206963823 GO:0004177 aminopeptidase activity 10/2209 40/18639 0.25 2.10943866002716 0.0160255436366241 0.122170039452042 GO:0008408 3'-5' exonuclease activity 13/2209 58/18639 0.224137931034483 1.89122086761056 0.0165028799776822 0.125037158113114 GO:0043236 laminin binding 8/2209 29/18639 0.275862068965517 2.32765645244376 0.0167249583760343 0.12594709508782 GO:0005540 hyaluronic acid binding 7/2209 24/18639 0.291666666666667 2.46101177003169 0.0181764578718854 0.135476749009478 GO:0016229 steroid dehydrogenase activity 9/2209 35/18639 0.257142857142857 2.16970833602794 0.0182098302312335 0.135476749009478 GO:0061650 ubiquitin-like protein conjugating enzyme activity 10/2209 41/18639 0.24390243902439 2.05798893661186 0.0190055437355595 0.138346584965338 GO:0005346 purine ribonucleotide transmembrane transporter activity 6/2209 19/18639 0.315789473684211 2.66455409687641 0.0190436594689129 0.138346584965338 GO:0005520 insulin-like growth factor binding 6/2209 19/18639 0.315789473684211 2.66455409687641 0.0190436594689129 0.138346584965338 GO:0008301 DNA binding, bending 6/2209 19/18639 0.315789473684211 2.66455409687641 0.0190436594689129 0.138346584965338 GO:0019199 transmembrane receptor protein kinase activity 16/2209 78/18639 0.205128205128205 1.73082146463767 0.019295139892363 0.139353788111511 GO:0140101 catalytic activity, acting on a tRNA 25/2209 139/18639 0.179856115107914 1.51758176980371 0.0215959345519829 0.155063832393598 GO:0005200 structural constituent of cytoskeleton 21/2209 112/18639 0.1875 1.58207899502037 0.0218213452406677 0.155776655330778 GO:0051879 Hsp90 protein binding 10/2209 42/18639 0.238095238095238 2.00898920002587 0.0223722193971228 0.157237496056841 GO:0005522 profilin binding 4/2209 10/18639 0.4 3.37510185604346 0.0229172059030213 0.157237496056841 GO:0005528 FK506 binding 4/2209 10/18639 0.4 3.37510185604346 0.0229172059030213 0.157237496056841 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2209 10/18639 0.4 3.37510185604346 0.0229172059030213 0.157237496056841 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/2209 10/18639 0.4 3.37510185604346 0.0229172059030213 0.157237496056841 GO:0051880 G-quadruplex DNA binding 4/2209 10/18639 0.4 3.37510185604346 0.0229172059030213 0.157237496056841 GO:0098505 G-rich strand telomeric DNA binding 4/2209 10/18639 0.4 3.37510185604346 0.0229172059030213 0.157237496056841 GO:0005525 GTP binding 58/2209 378/18639 0.153439153439153 1.29468192890556 0.0234287403544138 0.159809069980629 GO:0008173 RNA methyltransferase activity 14/2209 67/18639 0.208955223880597 1.76311290987345 0.0236802103695993 0.159809069980629 GO:0050840 extracellular matrix binding 14/2209 67/18639 0.208955223880597 1.76311290987345 0.0236802103695993 0.159809069980629 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/2209 20/18639 0.3 2.53132639203259 0.024541904553118 0.161760620240601 GO:0030742 GTP-dependent protein binding 6/2209 20/18639 0.3 2.53132639203259 0.024541904553118 0.161760620240601 GO:0043024 ribosomal small subunit binding 6/2209 20/18639 0.3 2.53132639203259 0.024541904553118 0.161760620240601 GO:0031386 protein tag activity 5/2209 15/18639 0.333333333333333 2.81258488003622 0.0251763623559954 0.161760620240601 GO:0141047 molecular tag activity 5/2209 15/18639 0.333333333333333 2.81258488003622 0.0251763623559954 0.161760620240601 GO:0005004 GPI-linked ephrin receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0005008 hepatocyte growth factor receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0005009 insulin receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0005011 macrophage colony-stimulating factor receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0005018 platelet-derived growth factor alpha-receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0005020 stem cell factor receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0008288 boss receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0036332 placental growth factor receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0038062 protein tyrosine kinase collagen receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0060175 brain-derived neurotrophic factor receptor activity 11/2209 49/18639 0.224489795918367 1.89418981716725 0.0259340913422179 0.161760620240601 GO:0003713 transcription coactivator activity 41/2209 256/18639 0.16015625 1.3513591415799 0.0275341875898322 0.170877998359009 GO:0031369 translation initiation factor binding 8/2209 32/18639 0.25 2.10943866002716 0.0297817804918952 0.180435349867284 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/2209 32/18639 0.25 2.10943866002716 0.0297817804918952 0.180435349867284 GO:0070717 poly-purine tract binding 8/2209 32/18639 0.25 2.10943866002716 0.0297817804918952 0.180435349867284 GO:0005017 platelet-derived growth factor receptor activity 11/2209 50/18639 0.22 1.8563060208239 0.0298047055651223 0.180435349867284 GO:0005019 platelet-derived growth factor beta-receptor activity 11/2209 50/18639 0.22 1.8563060208239 0.0298047055651223 0.180435349867284 GO:0019001 guanyl nucleotide binding 60/2209 400/18639 0.15 1.2656631960163 0.0323020354805529 0.192288838443016 GO:0032561 guanyl ribonucleotide binding 60/2209 400/18639 0.15 1.2656631960163 0.0323020354805529 0.192288838443016 GO:0004523 RNA-DNA hybrid ribonuclease activity 4/2209 11/18639 0.363636363636364 3.06827441458496 0.032696887508529 0.192288838443016 GO:0015173 aromatic amino acid transmembrane transporter activity 4/2209 11/18639 0.363636363636364 3.06827441458496 0.032696887508529 0.192288838443016 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/2209 11/18639 0.363636363636364 3.06827441458496 0.032696887508529 0.192288838443016 GO:0034713 type I transforming growth factor beta receptor binding 4/2209 11/18639 0.363636363636364 3.06827441458496 0.032696887508529 0.192288838443016 GO:0008142 oxysterol binding 5/2209 16/18639 0.3125 2.63679832503395 0.0331331546752292 0.193016254829755 GO:0043023 ribosomal large subunit binding 5/2209 16/18639 0.3125 2.63679832503395 0.0331331546752292 0.193016254829755 GO:0001671 ATPase activator activity 7/2209 27/18639 0.259259259259259 2.18756601780595 0.034059692794893 0.193905739520732 GO:0008266 poly(U) RNA binding 7/2209 27/18639 0.259259259259259 2.18756601780595 0.034059692794893 0.193905739520732 GO:0005010 insulin-like growth factor receptor activity 11/2209 51/18639 0.215686274509804 1.81990786355285 0.0340708870251003 0.193905739520732 GO:0005021 vascular endothelial growth factor receptor activity 11/2209 51/18639 0.215686274509804 1.81990786355285 0.0340708870251003 0.193905739520732 GO:0005030 neurotrophin receptor activity 11/2209 51/18639 0.215686274509804 1.81990786355285 0.0340708870251003 0.193905739520732 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/2209 33/18639 0.242424242424242 2.04551627638998 0.0353603010163348 0.200320971354007 GO:0003774 cytoskeletal motor activity 26/2209 153/18639 0.169934640522876 1.43386680158709 0.0369185871701866 0.208193859156075 GO:0034062 5'-3' RNA polymerase activity 6/2209 22/18639 0.272727272727273 2.30120581093872 0.0384851400594613 0.215064017979343 GO:0097747 RNA polymerase activity 6/2209 22/18639 0.272727272727273 2.30120581093872 0.0384851400594613 0.215064017979343 GO:0016866 intramolecular transferase activity 7/2209 28/18639 0.25 2.10943866002716 0.0409202295789308 0.22764181770261 GO:0008175 tRNA methyltransferase activity 8/2209 34/18639 0.235294117647059 1.98535403296674 0.0416031502289817 0.229374511307109 GO:0090482 vitamin transmembrane transporter activity 8/2209 34/18639 0.235294117647059 1.98535403296674 0.0416031502289817 0.229374511307109 GO:0004550 nucleoside diphosphate kinase activity 5/2209 17/18639 0.294117647058824 2.48169254120843 0.0424866475309811 0.232172609295406 GO:0032977 membrane insertase activity 5/2209 17/18639 0.294117647058824 2.48169254120843 0.0424866475309811 0.232172609295406 GO:0038064 collagen receptor activity 11/2209 53/18639 0.207547169811321 1.75123209511689 0.0438583052265525 0.238612365439614 GO:0005049 nuclear export signal receptor activity 4/2209 12/18639 0.333333333333333 2.81258488003622 0.0445522183349716 0.239226041929086 GO:0005527 macrolide binding 4/2209 12/18639 0.333333333333333 2.81258488003622 0.0445522183349716 0.239226041929086 GO:0043047 single-stranded telomeric DNA binding 4/2209 12/18639 0.333333333333333 2.81258488003622 0.0445522183349716 0.239226041929086 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 22/2209 128/18639 0.171875 1.45023907876867 0.0464248192528655 0.248201955745839 GO:0000295 adenine nucleotide transmembrane transporter activity 6/2209 23/18639 0.260869565217391 2.20115338437617 0.0470192746088211 0.249222335372936 GO:0004602 glutathione peroxidase activity 6/2209 23/18639 0.260869565217391 2.20115338437617 0.0470192746088211 0.249222335372936 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/2209 41/18639 0.219512195121951 1.85219004295068 0.0474661955327206 0.250516031978247 GO:0051287 NAD binding 11/2209 54/18639 0.203703703703704 1.71880187113324 0.049409884928209 0.25966471440995 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 21/2209 122/18639 0.172131147540984 1.45240038887116 0.0500940646504976 0.262144787471883 GO:0031491 nucleosome binding 14/2209 74/18639 0.189189189189189 1.59633195893947 0.0507100779494969 0.264248718428813 GO:0000400 four-way junction DNA binding 5/2209 18/18639 0.277777777777778 2.34382073336351 0.0532704845847449 0.274121035259 GO:0008308 voltage-gated monoatomic anion channel activity 5/2209 18/18639 0.277777777777778 2.34382073336351 0.0532704845847449 0.274121035259 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/2209 18/18639 0.277777777777778 2.34382073336351 0.0532704845847449 0.274121035259 GO:0016859 cis-trans isomerase activity 9/2209 42/18639 0.214285714285714 1.80809028002328 0.0543100072060655 0.278310617840211 GO:0042393 histone binding 38/2209 247/18639 0.153846153846154 1.29811609847825 0.055316369739578 0.282010013662691 GO:0003725 double-stranded RNA binding 14/2209 75/18639 0.186666666666667 1.57504753282028 0.0558279171199475 0.282010013662691 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/2209 36/18639 0.222222222222222 1.87505658669081 0.0561736545433376 0.282010013662691 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/2209 36/18639 0.222222222222222 1.87505658669081 0.0561736545433376 0.282010013662691 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/2209 36/18639 0.222222222222222 1.87505658669081 0.0561736545433376 0.282010013662691 GO:0050699 WW domain binding 6/2209 24/18639 0.25 2.10943866002716 0.0566335468544663 0.283167734272332 GO:0015215 nucleotide transmembrane transporter activity 7/2209 30/18639 0.233333333333333 1.96880941602535 0.057176981287068 0.283588642126622 GO:0035925 mRNA 3'-UTR AU-rich region binding 7/2209 30/18639 0.233333333333333 1.96880941602535 0.057176981287068 0.283588642126622 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/2209 13/18639 0.307692307692308 2.59623219695651 0.0584881352177646 0.284381287377714 GO:0008253 5'-nucleotidase activity 4/2209 13/18639 0.307692307692308 2.59623219695651 0.0584881352177646 0.284381287377714 GO:0009982 pseudouridine synthase activity 4/2209 13/18639 0.307692307692308 2.59623219695651 0.0584881352177646 0.284381287377714 GO:0019855 calcium channel inhibitor activity 4/2209 13/18639 0.307692307692308 2.59623219695651 0.0584881352177646 0.284381287377714 GO:0140666 annealing activity 4/2209 13/18639 0.307692307692308 2.59623219695651 0.0584881352177646 0.284381287377714 GO:0030295 protein kinase activator activity 23/2209 139/18639 0.165467625899281 1.39617522821942 0.061028486491066 0.295569336535163 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 22/2209 132/18639 0.166666666666667 1.40629244001811 0.0616692528468556 0.297505965882291 GO:0019210 kinase inhibitor activity 16/2209 90/18639 0.177777777777778 1.50004526935265 0.0627908213044398 0.30173799342795 GO:0005507 copper ion binding 12/2209 63/18639 0.19047619047619 1.60719136002069 0.0642607306415738 0.307604660241642 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/2209 19/18639 0.263157894736842 2.22046174739701 0.0654943506975419 0.311098165813324 GO:0008574 plus-end-directed microtubule motor activity 5/2209 19/18639 0.263157894736842 2.22046174739701 0.0654943506975419 0.311098165813324 GO:0015605 organophosphate ester transmembrane transporter activity 10/2209 50/18639 0.2 1.68755092802173 0.0658683923134313 0.311676109222558 GO:0008237 metallopeptidase activity 29/2209 184/18639 0.157608695652174 1.3298635030606 0.0665907740379243 0.313891625713116 GO:0004860 protein kinase inhibitor activity 15/2209 84/18639 0.178571428571429 1.5067419000194 0.0678063032627507 0.318406024826985 GO:0015932 nucleobase-containing compound transmembrane transporter activity 11/2209 57/18639 0.192982456140351 1.62833861475781 0.0688407535774204 0.322039131318615 GO:0016741 transferase activity, transferring one-carbon groups 33/2209 215/18639 0.153488372093023 1.29509722383063 0.0718243745544224 0.334728688961176 GO:0032182 ubiquitin-like protein binding 20/2209 120/18639 0.166666666666667 1.40629244001811 0.072144676037162 0.334957424458252 GO:0005109 frizzled binding 8/2209 38/18639 0.210526315789474 1.77636939791761 0.0736266512967786 0.339286993848961 GO:0043531 ADP binding 8/2209 38/18639 0.210526315789474 1.77636939791761 0.0736266512967786 0.339286993848961 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 4/2209 14/18639 0.285714285714286 2.41078704003104 0.0744601205324886 0.339329331577946 GO:0098847 sequence-specific single stranded DNA binding 4/2209 14/18639 0.285714285714286 2.41078704003104 0.0744601205324886 0.339329331577946 GO:1990825 sequence-specific mRNA binding 4/2209 14/18639 0.285714285714286 2.41078704003104 0.0744601205324886 0.339329331577946 GO:0140142 nucleocytoplasmic carrier activity 7/2209 32/18639 0.21875 1.84575882752377 0.0769205322622163 0.349253151999401 GO:0004518 nuclease activity 32/2209 209/18639 0.15311004784689 1.29190501666735 0.0772826859231167 0.349612150604576 GO:0008143 poly(A) binding 6/2209 26/18639 0.230769230769231 1.94717414771738 0.0791405509363962 0.3528674372115 GO:0015216 purine nucleotide transmembrane transporter activity 6/2209 26/18639 0.230769230769231 1.94717414771738 0.0791405509363962 0.3528674372115 GO:0050750 low-density lipoprotein particle receptor binding 6/2209 26/18639 0.230769230769231 1.94717414771738 0.0791405509363962 0.3528674372115 GO:0000339 RNA cap binding 5/2209 20/18639 0.25 2.10943866002716 0.0791451660790166 0.3528674372115 GO:0002020 protease binding 22/2209 136/18639 0.161764705882353 1.36493089766463 0.0801004944349131 0.355842124557977 GO:0003924 GTPase activity 48/2209 331/18639 0.145015105740181 1.22360188134506 0.0806684114382255 0.357080602602898 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/2209 39/18639 0.205128205128205 1.73082146463767 0.0834528149244926 0.36808652297053 GO:0070063 RNA polymerase binding 11/2209 59/18639 0.186440677966102 1.57314069561348 0.0841885888414958 0.370010345975969 GO:0008235 metalloexopeptidase activity 12/2209 66/18639 0.181818181818182 1.53413720729248 0.0856041836892928 0.374897754809492 GO:0008168 methyltransferase activity 31/2209 204/18639 0.151960784313725 1.28220781295769 0.0874306955052499 0.381543847876267 GO:0004364 glutathione transferase activity 6/2209 27/18639 0.222222222222222 1.87505658669081 0.0920207961196828 0.39477901944817 GO:0008320 protein transmembrane transporter activity 6/2209 27/18639 0.222222222222222 1.87505658669081 0.0920207961196828 0.39477901944817 GO:0004559 alpha-mannosidase activity 4/2209 15/18639 0.266666666666667 2.25006790402897 0.0923814871421224 0.39477901944817 GO:0005523 tropomyosin binding 4/2209 15/18639 0.266666666666667 2.25006790402897 0.0923814871421224 0.39477901944817 GO:0008252 nucleotidase activity 4/2209 15/18639 0.266666666666667 2.25006790402897 0.0923814871421224 0.39477901944817 GO:0051371 muscle alpha-actinin binding 4/2209 15/18639 0.266666666666667 2.25006790402897 0.0923814871421224 0.39477901944817 GO:0016500 protein-hormone receptor activity 12/2209 67/18639 0.17910447761194 1.51123963703438 0.0935918720173909 0.39857228255682 GO:0019208 phosphatase regulator activity 19/2209 117/18639 0.162393162393162 1.37023365950482 0.0954925879372189 0.405269230592665 GO:0005506 iron ion binding 24/2209 154/18639 0.155844155844156 1.31497474910784 0.0975723642726477 0.412677636564109 GO:0030332 cyclin binding 7/2209 34/18639 0.205882352941176 1.7371847788459 0.100167111416872 0.419409245488866 GO:0003925 G protein activity 10/2209 54/18639 0.185185185185185 1.56254715557568 0.100182775238231 0.419409245488866 GO:0140463 chromatin-protein adaptor activity 10/2209 54/18639 0.185185185185185 1.56254715557568 0.100182775238231 0.419409245488866 GO:0016836 hydro-lyase activity 11/2209 61/18639 0.180327868852459 1.52156231215074 0.101486131614886 0.423430312649946 GO:0019003 GDP binding 13/2209 75/18639 0.173333333333333 1.46254413761883 0.10197518784372 0.424038239013448 GO:0019209 kinase activator activity 23/2209 148/18639 0.155405405405405 1.31127268055742 0.105473672918131 0.424861308830985 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:0005345 purine nucleobase transmembrane transporter activity 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:0033204 ribonuclease P RNA binding 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:0050815 phosphoserine residue binding 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:0140940 histone H2A methyltransferase activity 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:1990259 histone H2AQ104 methyltransferase activity 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:1990757 ubiquitin ligase activator activity 3/2209 10/18639 0.3 2.53132639203259 0.105503646804654 0.424861308830985 GO:0046625 sphingolipid binding 6/2209 28/18639 0.214285714285714 1.80809028002328 0.105957314267161 0.424861308830985 GO:0051393 alpha-actinin binding 6/2209 28/18639 0.214285714285714 1.80809028002328 0.105957314267161 0.424861308830985 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/2209 48/18639 0.1875 1.58207899502037 0.108408822804294 0.433284453602921 GO:0140035 ubiquitin-like protein reader activity 5/2209 22/18639 0.227272727272727 1.9176715091156 0.110572246640873 0.440505563230575 GO:0000062 fatty-acyl-CoA binding 4/2209 16/18639 0.25 2.10943866002716 0.112130931297754 0.441024522779381 GO:0015923 mannosidase activity 4/2209 16/18639 0.25 2.10943866002716 0.112130931297754 0.441024522779381 GO:0070411 I-SMAD binding 4/2209 16/18639 0.25 2.10943866002716 0.112130931297754 0.441024522779381 GO:0140328 floppase activity 4/2209 16/18639 0.25 2.10943866002716 0.112130931297754 0.441024522779381 GO:0061631 ubiquitin conjugating enzyme activity 7/2209 35/18639 0.2 1.68755092802173 0.113075263195493 0.441923892552007 GO:0140566 histone reader activity 7/2209 35/18639 0.2 1.68755092802173 0.113075263195493 0.441923892552007 GO:0008307 structural constituent of muscle 8/2209 42/18639 0.19047619047619 1.60719136002069 0.117291474992487 0.456955746421835 GO:0097110 scaffold protein binding 12/2209 70/18639 0.171428571428571 1.44647222401862 0.120177659722105 0.466727703637733 GO:0004712 protein serine/threonine/tyrosine kinase activity 8/2209 43/18639 0.186046511627907 1.5698148167644 0.129983465508022 0.489455572653113 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 25/2209 167/18639 0.149700598802395 1.26313692217195 0.130079564599734 0.489455572653113 GO:0043130 ubiquitin binding 16/2209 100/18639 0.16 1.35004074241738 0.130385854238933 0.489455572653113 GO:0000099 sulfur amino acid transmembrane transporter activity 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0002162 dystroglycan binding 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0005225 volume-sensitive anion channel activity 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0010854 adenylate cyclase regulator activity 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0015205 nucleobase transmembrane transporter activity 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0032404 mismatch repair complex binding 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0032794 GTPase activating protein binding 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0050786 RAGE receptor binding 3/2209 11/18639 0.272727272727273 2.30120581093872 0.132806181540701 0.489455572653113 GO:0004549 tRNA-specific ribonuclease activity 4/2209 17/18639 0.235294117647059 1.98535403296674 0.13355994168753 0.489455572653113 GO:0030169 low-density lipoprotein particle binding 4/2209 17/18639 0.235294117647059 1.98535403296674 0.13355994168753 0.489455572653113 GO:0051787 misfolded protein binding 4/2209 17/18639 0.235294117647059 1.98535403296674 0.13355994168753 0.489455572653113 GO:0070492 oligosaccharide binding 4/2209 17/18639 0.235294117647059 1.98535403296674 0.13355994168753 0.489455572653113 GO:1901567 fatty acid derivative binding 4/2209 17/18639 0.235294117647059 1.98535403296674 0.13355994168753 0.489455572653113 GO:1990226 histone methyltransferase binding 4/2209 17/18639 0.235294117647059 1.98535403296674 0.13355994168753 0.489455572653113 GO:1901681 sulfur compound binding 39/2209 275/18639 0.141818181818182 1.19662702168814 0.134277720522766 0.490630132679336 GO:0001968 fibronectin binding 6/2209 30/18639 0.2 1.68755092802173 0.136849763590061 0.497086641275662 GO:0016769 transferase activity, transferring nitrogenous groups 6/2209 30/18639 0.2 1.68755092802173 0.136849763590061 0.497086641275662 GO:0046332 SMAD binding 13/2209 79/18639 0.164556962025316 1.3884912698913 0.137910931779963 0.499472142956758 GO:0042805 actinin binding 7/2209 37/18639 0.189189189189189 1.59633195893947 0.141341056368871 0.510398259109812 GO:0038024 cargo receptor activity 11/2209 65/18639 0.169230769230769 1.42792770832608 0.141850519493724 0.510744581850582 GO:0019205 nucleobase-containing compound kinase activity 8/2209 44/18639 0.181818181818182 1.53413720729248 0.143349038351637 0.514639716175208 GO:0016830 carbon-carbon lyase activity 9/2209 51/18639 0.176470588235294 1.48901552472506 0.14377907891288 0.514687427412772 GO:0070300 phosphatidic acid binding 5/2209 24/18639 0.208333333333333 1.75786555002263 0.147065929753805 0.524722417562365 GO:0008238 exopeptidase activity 16/2209 102/18639 0.156862745098039 1.32356935531116 0.147593182735857 0.524722417562365 GO:0048306 calcium-dependent protein binding 13/2209 80/18639 0.1625 1.37113512901765 0.147857005110691 0.524722417562365 GO:0004521 RNA endonuclease activity 12/2209 73/18639 0.164383561643836 1.38702816001786 0.150607164006047 0.532950852571541 GO:0017147 Wnt-protein binding 6/2209 31/18639 0.193548387096774 1.63311380131135 0.153707563576685 0.54082290888093 GO:0070325 lipoprotein particle receptor binding 6/2209 31/18639 0.193548387096774 1.63311380131135 0.153707563576685 0.54082290888093 GO:0000146 microfilament motor activity 7/2209 38/18639 0.184210526315789 1.55432322317791 0.156631405901279 0.54802497651554 GO:0004722 protein serine/threonine phosphatase activity 16/2209 103/18639 0.155339805825243 1.31071916739552 0.156641956850191 0.54802497651554 GO:0001618 virus receptor activity 13/2209 81/18639 0.160493827160494 1.35420753483225 0.158173711950924 0.548895476865182 GO:0004526 ribonuclease P activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0008179 adenylate cyclase binding 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0015368 calcium:monoatomic cation antiporter activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0016801 hydrolase activity, acting on ether bonds 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0016803 ether hydrolase activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0016840 carbon-nitrogen lyase activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0017166 vinculin binding 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0035251 UDP-glucosyltransferase activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0036009 protein-glutamine N-methyltransferase activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0097371 MDM2/MDM4 family protein binding 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/2209 12/18639 0.25 2.10943866002716 0.162224169275945 0.548895476865182 GO:0019211 phosphatase activator activity 5/2209 25/18639 0.2 1.68755092802173 0.166997246376973 0.563501637364921 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 10/2209 60/18639 0.166666666666667 1.40629244001811 0.167726084221949 0.564418839275494 GO:0140272 exogenous protein binding 13/2209 82/18639 0.158536585365854 1.33769280879771 0.168851523108509 0.566662040866872 GO:1901505 carbohydrate derivative transmembrane transporter activity 9/2209 53/18639 0.169811320754717 1.43282625964109 0.17021346384261 0.56759556284673 GO:0019842 vitamin binding 22/2209 150/18639 0.146666666666667 1.23753734721593 0.171357798227417 0.56759556284673 GO:0022884 macromolecule transmembrane transporter activity 6/2209 32/18639 0.1875 1.58207899502037 0.171427647726178 0.56759556284673 GO:0071813 lipoprotein particle binding 6/2209 32/18639 0.1875 1.58207899502037 0.171427647726178 0.56759556284673 GO:0071814 protein-lipid complex binding 6/2209 32/18639 0.1875 1.58207899502037 0.171427647726178 0.56759556284673 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/2209 39/18639 0.179487179487179 1.51446878155796 0.172639222677451 0.570078716595325 GO:0003777 microtubule motor activity 11/2209 68/18639 0.161764705882353 1.36493089766463 0.176902503202429 0.582598910546668 GO:0008381 mechanosensitive monoatomic ion channel activity 4/2209 19/18639 0.210526315789474 1.77636939791761 0.180767902807772 0.585953700702359 GO:0030506 ankyrin binding 4/2209 19/18639 0.210526315789474 1.77636939791761 0.180767902807772 0.585953700702359 GO:0070003 threonine-type peptidase activity 4/2209 19/18639 0.210526315789474 1.77636939791761 0.180767902807772 0.585953700702359 GO:0097001 ceramide binding 4/2209 19/18639 0.210526315789474 1.77636939791761 0.180767902807772 0.585953700702359 GO:0120227 acyl-CoA binding 4/2209 19/18639 0.210526315789474 1.77636939791761 0.180767902807772 0.585953700702359 GO:0140036 ubiquitin-modified protein reader activity 4/2209 19/18639 0.210526315789474 1.77636939791761 0.180767902807772 0.585953700702359 GO:0044325 transmembrane transporter binding 20/2209 136/18639 0.147058823529412 1.24084627060421 0.181984009436206 0.588351444119671 GO:0005160 transforming growth factor beta receptor binding 5/2209 26/18639 0.192307692307692 1.62264512309782 0.187915507196158 0.604153912053315 GO:0008514 organic anion transmembrane transporter activity 37/2209 269/18639 0.137546468401487 1.1605833519852 0.188463062889268 0.604153912053315 GO:0050997 quaternary ammonium group binding 7/2209 40/18639 0.175 1.47660706201901 0.189317865558407 0.604153912053315 GO:0061791 GTPase motor activity 7/2209 40/18639 0.175 1.47660706201901 0.189317865558407 0.604153912053315 GO:1990606 membrane scission GTPase motor activity 7/2209 40/18639 0.175 1.47660706201901 0.189317865558407 0.604153912053315 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2209 13/18639 0.230769230769231 1.94717414771738 0.193344979493399 0.60758536812811 GO:0008035 high-density lipoprotein particle binding 3/2209 13/18639 0.230769230769231 1.94717414771738 0.193344979493399 0.60758536812811 GO:0019104 DNA N-glycosylase activity 3/2209 13/18639 0.230769230769231 1.94717414771738 0.193344979493399 0.60758536812811 GO:0039706 co-receptor binding 3/2209 13/18639 0.230769230769231 1.94717414771738 0.193344979493399 0.60758536812811 GO:0070700 BMP receptor binding 3/2209 13/18639 0.230769230769231 1.94717414771738 0.193344979493399 0.60758536812811 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/2209 13/18639 0.230769230769231 1.94717414771738 0.193344979493399 0.60758536812811 GO:0019888 protein phosphatase regulator activity 16/2209 107/18639 0.149532710280374 1.26172032001625 0.195660778235507 0.613302185585917 GO:0001221 transcription coregulator binding 17/2209 115/18639 0.147826086956522 1.2473202511465 0.199660621389173 0.622678958120274 GO:0017124 SH3 domain binding 17/2209 115/18639 0.147826086956522 1.2473202511465 0.199660621389173 0.622678958120274 GO:0016004 phospholipase activator activity 4/2209 20/18639 0.2 1.68755092802173 0.206173586989961 0.634755253501721 GO:0042288 MHC class I protein binding 4/2209 20/18639 0.2 1.68755092802173 0.206173586989961 0.634755253501721 GO:0052745 inositol phosphate phosphatase activity 4/2209 20/18639 0.2 1.68755092802173 0.206173586989961 0.634755253501721 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/2209 41/18639 0.170731707317073 1.44059225562831 0.206616689803799 0.634755253501721 GO:0016877 ligase activity, forming carbon-sulfur bonds 7/2209 41/18639 0.170731707317073 1.44059225562831 0.206616689803799 0.634755253501721 GO:0140318 protein transporter activity 7/2209 41/18639 0.170731707317073 1.44059225562831 0.206616689803799 0.634755253501721 GO:1901682 sulfur compound transmembrane transporter activity 10/2209 63/18639 0.158730158730159 1.33932613335058 0.208000757209986 0.637421675320925 GO:0016831 carboxy-lyase activity 6/2209 34/18639 0.176470588235294 1.48901552472506 0.209180349656202 0.639449831251012 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/2209 27/18639 0.185185185185185 1.56254715557568 0.209709759713538 0.639485316657332 GO:0035173 histone kinase activity 48/2209 360/18639 0.133333333333333 1.12503395201449 0.210813844484191 0.641268714132946 GO:0019212 phosphatase inhibitor activity 9/2209 56/18639 0.160714285714286 1.35606771001746 0.213670177475155 0.646771247994647 GO:0030170 pyridoxal phosphate binding 9/2209 56/18639 0.160714285714286 1.35606771001746 0.213670177475155 0.646771247994647 GO:0140299 molecular sensor activity 11/2209 71/18639 0.154929577464789 1.30725776114359 0.215613231658895 0.651057068701065 GO:0061134 peptidase regulator activity 31/2209 226/18639 0.13716814159292 1.15739112320074 0.217679274108486 0.655692447619463 GO:0005539 glycosaminoglycan binding 33/2209 242/18639 0.136363636363636 1.15060290546936 0.219149123795708 0.658513790481021 GO:0019894 kinesin binding 7/2209 42/18639 0.166666666666667 1.40629244001811 0.224481732766062 0.665450195024515 GO:0042056 chemoattractant activity 7/2209 42/18639 0.166666666666667 1.40629244001811 0.224481732766062 0.665450195024515 GO:0048487 beta-tubulin binding 7/2209 42/18639 0.166666666666667 1.40629244001811 0.224481732766062 0.665450195024515 GO:0008174 mRNA methyltransferase activity 3/2209 14/18639 0.214285714285714 1.80809028002328 0.225768122846374 0.665450195024515 GO:0008191 metalloendopeptidase inhibitor activity 3/2209 14/18639 0.214285714285714 1.80809028002328 0.225768122846374 0.665450195024515 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/2209 14/18639 0.214285714285714 1.80809028002328 0.225768122846374 0.665450195024515 GO:0044548 S100 protein binding 3/2209 14/18639 0.214285714285714 1.80809028002328 0.225768122846374 0.665450195024515 GO:1901474 azole transmembrane transporter activity 3/2209 14/18639 0.214285714285714 1.80809028002328 0.225768122846374 0.665450195024515 GO:0004222 metalloendopeptidase activity 16/2209 110/18639 0.145454545454545 1.22730976583398 0.227661863068714 0.668780705438225 GO:0016504 peptidase activator activity 9/2209 57/18639 0.157894736842105 1.33227704843821 0.229052013200939 0.668780705438225 GO:0070279 vitamin B6 binding 9/2209 57/18639 0.157894736842105 1.33227704843821 0.229052013200939 0.668780705438225 GO:0034061 DNA polymerase activity 6/2209 35/18639 0.171428571428571 1.44647222401862 0.229064160648072 0.668780705438225 GO:0046875 ephrin receptor binding 5/2209 28/18639 0.178571428571429 1.5067419000194 0.232264639158403 0.670948218904574 GO:0019200 carbohydrate kinase activity 4/2209 21/18639 0.19047619047619 1.60719136002069 0.232522945498913 0.670948218904574 GO:0051010 microtubule plus-end binding 4/2209 21/18639 0.19047619047619 1.60719136002069 0.232522945498913 0.670948218904574 GO:0072542 protein phosphatase activator activity 4/2209 21/18639 0.19047619047619 1.60719136002069 0.232522945498913 0.670948218904574 GO:1904047 S-adenosyl-L-methionine binding 4/2209 21/18639 0.19047619047619 1.60719136002069 0.232522945498913 0.670948218904574 GO:0020037 heme binding 20/2209 142/18639 0.140845070422535 1.18841614649418 0.237904556722042 0.684876754199818 GO:0004175 endopeptidase activity 53/2209 405/18639 0.130864197530864 1.10419998994014 0.239052870067673 0.686582080310643 GO:0048156 tau protein binding 7/2209 43/18639 0.162790697674419 1.37358796466885 0.242856395844014 0.69588781639758 GO:0015101 organic cation transmembrane transporter activity 12/2209 81/18639 0.148148148148148 1.25003772446054 0.248368896048547 0.703660522438899 GO:0000993 RNA polymerase II complex binding 6/2209 36/18639 0.166666666666667 1.40629244001811 0.249514965927794 0.703660522438899 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/2209 36/18639 0.166666666666667 1.40629244001811 0.249514965927794 0.703660522438899 GO:0140297 DNA-binding transcription factor binding 63/2209 488/18639 0.129098360655738 1.08930029165337 0.250910969256341 0.703660522438899 GO:0005048 signal sequence binding 8/2209 51/18639 0.156862745098039 1.32356935531116 0.253109197256213 0.703660522438899 GO:0030544 Hsp70 protein binding 8/2209 51/18639 0.156862745098039 1.32356935531116 0.253109197256213 0.703660522438899 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 5/2209 29/18639 0.172413793103448 1.45478528277735 0.255462437497766 0.703660522438899 GO:0051861 glycolipid binding 5/2209 29/18639 0.172413793103448 1.45478528277735 0.255462437497766 0.703660522438899 GO:0097472 cyclin-dependent protein kinase activity 5/2209 29/18639 0.172413793103448 1.45478528277735 0.255462437497766 0.703660522438899 GO:0106222 lncRNA binding 5/2209 29/18639 0.172413793103448 1.45478528277735 0.255462437497766 0.703660522438899 GO:0033218 amide binding 33/2209 247/18639 0.133603238866397 1.12731134867848 0.25657184288361 0.703660522438899 GO:0019903 protein phosphatase binding 20/2209 144/18639 0.138888888888889 1.17191036668176 0.258019428931441 0.703660522438899 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0005041 low-density lipoprotein particle receptor activity 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0016846 carbon-sulfur lyase activity 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0031005 filamin binding 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0033130 acetylcholine receptor binding 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0061578 K63-linked deubiquitinase activity 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0120283 protein serine/threonine kinase binding 3/2209 15/18639 0.2 1.68755092802173 0.259114781772437 0.703660522438899 GO:0046906 tetrapyrrole binding 21/2209 152/18639 0.138157894736842 1.16574241738343 0.259312559642797 0.703660522438899 GO:0008649 rRNA methyltransferase activity 4/2209 22/18639 0.181818181818182 1.53413720729248 0.2596231008007 0.703660522438899 GO:0061133 endopeptidase activator activity 4/2209 22/18639 0.181818181818182 1.53413720729248 0.2596231008007 0.703660522438899 GO:0140784 metal ion sensor activity 4/2209 22/18639 0.181818181818182 1.53413720729248 0.2596231008007 0.703660522438899 GO:0004879 nuclear receptor activity 9/2209 59/18639 0.152542372881356 1.28711511459284 0.260958817516389 0.703660522438899 GO:0031593 polyubiquitin modification-dependent protein binding 9/2209 59/18639 0.152542372881356 1.28711511459284 0.260958817516389 0.703660522438899 GO:0043014 alpha-tubulin binding 7/2209 44/18639 0.159090909090909 1.34237005638092 0.261682112126355 0.703660522438899 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 12/2209 82/18639 0.146341463414634 1.23479336196712 0.262000445695411 0.703660522438899 GO:0004252 serine-type endopeptidase activity 24/2209 176/18639 0.136363636363636 1.15060290546936 0.262092178398294 0.703660522438899 GO:0141003 histone H2AX kinase activity 46/2209 354/18639 0.129943502824859 1.09643139391242 0.273630045189399 0.733043613468347 GO:0098531 ligand-modulated transcription factor activity 9/2209 60/18639 0.15 1.2656631960163 0.277411652803643 0.741565781845236 GO:0046915 transition metal ion transmembrane transporter activity 7/2209 45/18639 0.155555555555556 1.31253961068357 0.280898990671412 0.748699574508559 GO:0008236 serine-type peptidase activity 26/2209 194/18639 0.134020618556701 1.13083309609704 0.281292795604835 0.748699574508559 GO:0017022 myosin binding 11/2209 76/18639 0.144736842105263 1.22125396106836 0.286747281097806 0.754888967449868 GO:0003887 DNA-directed DNA polymerase activity 4/2209 23/18639 0.173913043478261 1.46743558958411 0.287285679920193 0.754888967449868 GO:0005158 insulin receptor binding 4/2209 23/18639 0.173913043478261 1.46743558958411 0.287285679920193 0.754888967449868 GO:0008171 O-methyltransferase activity 4/2209 23/18639 0.173913043478261 1.46743558958411 0.287285679920193 0.754888967449868 GO:0043274 phospholipase binding 4/2209 23/18639 0.173913043478261 1.46743558958411 0.287285679920193 0.754888967449868 GO:0140102 catalytic activity, acting on a rRNA 4/2209 23/18639 0.173913043478261 1.46743558958411 0.287285679920193 0.754888967449868 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2209 16/18639 0.1875 1.58207899502037 0.293034131881979 0.761888742893146 GO:0004708 MAP kinase kinase activity 3/2209 16/18639 0.1875 1.58207899502037 0.293034131881979 0.761888742893146 GO:0005159 insulin-like growth factor receptor binding 3/2209 16/18639 0.1875 1.58207899502037 0.293034131881979 0.761888742893146 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/2209 16/18639 0.1875 1.58207899502037 0.293034131881979 0.761888742893146 GO:0022858 alanine transmembrane transporter activity 3/2209 16/18639 0.1875 1.58207899502037 0.293034131881979 0.761888742893146 GO:0140996 histone H3 kinase activity 46/2209 357/18639 0.128851540616246 1.08721768471988 0.293927250160222 0.762605365436712 GO:0008201 heparin binding 23/2209 172/18639 0.133720930232558 1.12830439954941 0.300370503181141 0.776258035319657 GO:0030291 protein serine/threonine kinase inhibitor activity 7/2209 46/18639 0.152173913043478 1.2840061408861 0.300446429864612 0.776258035319657 GO:0003724 RNA helicase activity 11/2209 77/18639 0.142857142857143 1.20539352001552 0.301749132756791 0.777996198235149 GO:0015485 cholesterol binding 8/2209 54/18639 0.148148148148148 1.25003772446054 0.306619405941474 0.78890617987025 GO:0050431 transforming growth factor beta binding 4/2209 24/18639 0.166666666666667 1.40629244001811 0.31532962995347 0.797906881163239 GO:0060229 lipase activator activity 4/2209 24/18639 0.166666666666667 1.40629244001811 0.31532962995347 0.797906881163239 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/2209 24/18639 0.166666666666667 1.40629244001811 0.31532962995347 0.797906881163239 GO:0017171 serine hydrolase activity 26/2209 198/18639 0.131313131313131 1.10798798304457 0.318678220850833 0.797906881163239 GO:0140313 molecular sequestering activity 8/2209 55/18639 0.145454545454545 1.22730976583398 0.324986067638944 0.797906881163239 GO:0030246 carbohydrate binding 36/2209 280/18639 0.128571428571429 1.08485416801397 0.326356821854744 0.797906881163239 GO:0004659 prenyltransferase activity 3/2209 17/18639 0.176470588235294 1.48901552472506 0.327207172637934 0.797906881163239 GO:0016018 cyclosporin A binding 3/2209 17/18639 0.176470588235294 1.48901552472506 0.327207172637934 0.797906881163239 GO:0032183 SUMO binding 3/2209 17/18639 0.176470588235294 1.48901552472506 0.327207172637934 0.797906881163239 GO:0048038 quinone binding 3/2209 17/18639 0.176470588235294 1.48901552472506 0.327207172637934 0.797906881163239 GO:0008378 galactosyltransferase activity 5/2209 32/18639 0.15625 1.31839916251698 0.327738871972078 0.797906881163239 GO:0004721 phosphoprotein phosphatase activity 23/2209 175/18639 0.131428571428571 1.10896203841428 0.330819407702509 0.797906881163239 GO:0016874 ligase activity 22/2209 167/18639 0.131736526946108 1.11156049151132 0.33158975967342 0.797906881163239 GO:0008186 ATP-dependent activity, acting on RNA 11/2209 79/18639 0.139240506329114 1.17487722836956 0.332318459560285 0.797906881163239 GO:0004519 endonuclease activity 17/2209 127/18639 0.133858267716535 1.1294632195421 0.334369712443581 0.797906881163239 GO:0042826 histone deacetylase binding 17/2209 127/18639 0.133858267716535 1.1294632195421 0.334369712443581 0.797906881163239 GO:0030331 nuclear estrogen receptor binding 6/2209 40/18639 0.15 1.2656631960163 0.335364543788116 0.797906881163239 GO:0004090 carbonyl reductase (NADPH) activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0008190 eukaryotic initiation factor 4E binding 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0008519 ammonium channel activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0016783 sulfurtransferase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0016868 intramolecular phosphotransferase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0030957 Tat protein binding 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0031996 thioesterase binding 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0099122 RNA polymerase II C-terminal domain binding 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0140135 mechanosensitive monoatomic cation channel activity 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2209 10/18639 0.2 1.68755092802173 0.335960792068732 0.797906881163239 GO:0003712 transcription coregulator activity 62/2209 495/18639 0.125252525252525 1.05685007613482 0.339524699926003 0.804628425789935 GO:0061135 endopeptidase regulator activity 24/2209 184/18639 0.130434782608696 1.10057669218808 0.340093958107163 0.804628425789935 GO:0005537 D-mannose binding 4/2209 25/18639 0.16 1.35004074241738 0.343583417301375 0.805171765402653 GO:0008483 transaminase activity 4/2209 25/18639 0.16 1.35004074241738 0.343583417301375 0.805171765402653 GO:0015662 P-type ion transporter activity 4/2209 25/18639 0.16 1.35004074241738 0.343583417301375 0.805171765402653 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/2209 25/18639 0.16 1.35004074241738 0.343583417301375 0.805171765402653 GO:0140358 P-type transmembrane transporter activity 4/2209 25/18639 0.16 1.35004074241738 0.343583417301375 0.805171765402653 GO:0016779 nucleotidyltransferase activity 18/2209 136/18639 0.132352941176471 1.11676164354379 0.345826504471967 0.808893433755454 GO:0071889 14-3-3 protein binding 5/2209 33/18639 0.151515151515152 1.27844767274373 0.352345327792329 0.819115650797826 GO:0140416 transcription regulator inhibitor activity 5/2209 33/18639 0.151515151515152 1.27844767274373 0.352345327792329 0.819115650797826 GO:0030414 peptidase inhibitor activity 22/2209 169/18639 0.130177514792899 1.0984059294816 0.35284502432507 0.819115650797826 GO:0001530 lipopolysaccharide binding 6/2209 41/18639 0.146341463414634 1.23479336196712 0.357435604471142 0.819115650797826 GO:0042169 SH2 domain binding 6/2209 41/18639 0.146341463414634 1.23479336196712 0.357435604471142 0.819115650797826 GO:0001222 transcription corepressor binding 7/2209 49/18639 0.142857142857143 1.20539352001552 0.360467241779618 0.819115650797826 GO:0016763 pentosyltransferase activity 7/2209 49/18639 0.142857142857143 1.20539352001552 0.360467241779618 0.819115650797826 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2209 18/18639 0.166666666666667 1.40629244001811 0.361348649850712 0.819115650797826 GO:0008409 5'-3' exonuclease activity 3/2209 18/18639 0.166666666666667 1.40629244001811 0.361348649850712 0.819115650797826 GO:0030228 lipoprotein particle receptor activity 3/2209 18/18639 0.166666666666667 1.40629244001811 0.361348649850712 0.819115650797826 GO:0034185 apolipoprotein binding 3/2209 18/18639 0.166666666666667 1.40629244001811 0.361348649850712 0.819115650797826 GO:0070064 proline-rich region binding 3/2209 18/18639 0.166666666666667 1.40629244001811 0.361348649850712 0.819115650797826 GO:0033192 calmodulin-dependent protein phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0140791 histone H2AXS140 phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/2209 81/18639 0.135802469135802 1.14586791408883 0.363461843430938 0.819115650797826 GO:0008083 growth factor activity 21/2209 162/18639 0.12962962962963 1.09378300890297 0.36512811306239 0.821371984757835 GO:0004529 DNA exonuclease activity 4/2209 26/18639 0.153846153846154 1.29811609847825 0.371886673684142 0.82428411983814 GO:0008198 ferrous iron binding 4/2209 26/18639 0.153846153846154 1.29811609847825 0.371886673684142 0.82428411983814 GO:0050681 nuclear androgen receptor binding 4/2209 26/18639 0.153846153846154 1.29811609847825 0.371886673684142 0.82428411983814 GO:0008376 acetylgalactosaminyltransferase activity 5/2209 34/18639 0.147058823529412 1.24084627060421 0.377028944712351 0.82428411983814 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 5/2209 34/18639 0.147058823529412 1.24084627060421 0.377028944712351 0.82428411983814 GO:0033549 MAP kinase phosphatase activity 11/2209 82/18639 0.134146341463415 1.13189391513653 0.379181214911091 0.82428411983814 GO:0031492 nucleosomal DNA binding 6/2209 42/18639 0.142857142857143 1.20539352001552 0.379594583088655 0.82428411983814 GO:0043175 RNA polymerase core enzyme binding 6/2209 42/18639 0.142857142857143 1.20539352001552 0.379594583088655 0.82428411983814 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0019206 nucleoside kinase activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0019215 intermediate filament binding 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0034056 estrogen response element binding 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0035252 UDP-xylosyltransferase activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0042285 xylosyltransferase activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0045294 alpha-catenin binding 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0047676 arachidonate-CoA ligase activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0048185 activin binding 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0180030 inositol phosphate kinase activity 2/2209 11/18639 0.181818181818182 1.53413720729248 0.381106261074962 0.82428411983814 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 11/2209 83/18639 0.132530120481928 1.11825663905054 0.394963341332082 0.842972904667978 GO:0015245 fatty acid transmembrane transporter activity 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0022840 leak channel activity 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0022842 narrow pore channel activity 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0034987 immunoglobulin receptor binding 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0046527 glucosyltransferase activity 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0046624 sphingolipid transporter activity 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0050145 nucleoside monophosphate kinase activity 3/2209 19/18639 0.157894736842105 1.33227704843821 0.395207539921262 0.842972904667978 GO:0036002 pre-mRNA binding 8/2209 59/18639 0.135593220338983 1.14410232408253 0.39984735892356 0.845740029272882 GO:0045309 protein phosphorylated amino acid binding 8/2209 59/18639 0.135593220338983 1.14410232408253 0.39984735892356 0.845740029272882 GO:0070888 E-box binding 8/2209 59/18639 0.135593220338983 1.14410232408253 0.39984735892356 0.845740029272882 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/2209 27/18639 0.148148148148148 1.25003772446054 0.400091354374682 0.845740029272882 GO:0005154 epidermal growth factor receptor binding 5/2209 35/18639 0.142857142857143 1.20539352001552 0.401689742056398 0.845740029272882 GO:0043015 gamma-tubulin binding 5/2209 35/18639 0.142857142857143 1.20539352001552 0.401689742056398 0.845740029272882 GO:0008200 ion channel inhibitor activity 6/2209 43/18639 0.13953488372093 1.1773611125733 0.401768343182381 0.845740029272882 GO:0019902 phosphatase binding 24/2209 190/18639 0.126315789473684 1.06582163875057 0.401983317557232 0.845740029272882 GO:0016791 phosphatase activity 34/2209 273/18639 0.124542124542125 1.0508558892443 0.405866528664677 0.852457760035504 GO:0005516 calmodulin binding 26/2209 207/18639 0.1256038647343 1.05981459247741 0.407170603787491 0.853676764350796 GO:0052689 carboxylic ester hydrolase activity 12/2209 92/18639 0.130434782608696 1.10057669218808 0.408221550705662 0.853676764350796 GO:0017018 myosin phosphatase activity 11/2209 84/18639 0.130952380952381 1.10494406001423 0.410781888367453 0.853676764350796 GO:0032934 sterol binding 9/2209 68/18639 0.132352941176471 1.11676164354379 0.416026083991521 0.853676764350796 GO:0005080 protein kinase C binding 7/2209 52/18639 0.134615384615385 1.13585158616847 0.421325693005389 0.853676764350796 GO:0051219 phosphoprotein binding 12/2209 93/18639 0.129032258064516 1.08874253420757 0.423327489248435 0.853676764350796 GO:0016248 channel inhibitor activity 6/2209 44/18639 0.136363636363636 1.15060290546936 0.423887221770175 0.853676764350796 GO:0030547 signaling receptor inhibitor activity 6/2209 44/18639 0.136363636363636 1.15060290546936 0.423887221770175 0.853676764350796 GO:0000340 RNA 7-methylguanosine cap binding 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0003720 telomerase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0003995 acyl-CoA dehydrogenase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0004300 enoyl-CoA hydratase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0004859 phospholipase inhibitor activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0005095 GTPase inhibitor activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0010853 cyclase activator activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0015132 prostaglandin transmembrane transporter activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0016208 AMP binding 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0016273 arginine N-methyltransferase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0016274 protein-arginine N-methyltransferase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0031543 peptidyl-proline dioxygenase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0035497 cAMP response element binding 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0045295 gamma-catenin binding 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0070008 serine-type exopeptidase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:1990817 poly(A) RNA polymerase activity 2/2209 12/18639 0.166666666666667 1.40629244001811 0.424882679434765 0.853676764350796 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2209 36/18639 0.138888888888889 1.17191036668176 0.426234060786818 0.853676764350796 GO:0051019 mitogen-activated protein kinase binding 4/2209 28/18639 0.142857142857143 1.20539352001552 0.428062473577394 0.853676764350796 GO:0010851 cyclase regulator activity 3/2209 20/18639 0.15 1.2656631960163 0.428566472791493 0.853676764350796 GO:0016408 C-acyltransferase activity 3/2209 20/18639 0.15 1.2656631960163 0.428566472791493 0.853676764350796 GO:0031418 L-ascorbic acid binding 3/2209 20/18639 0.15 1.2656631960163 0.428566472791493 0.853676764350796 GO:0061608 nuclear import signal receptor activity 3/2209 20/18639 0.15 1.2656631960163 0.428566472791493 0.853676764350796 GO:0002039 p53 binding 9/2209 69/18639 0.130434782608696 1.10057669218808 0.43366279587567 0.861340604057201 GO:0015297 antiporter activity 17/2209 135/18639 0.125925925925926 1.06253206579146 0.433808790059578 0.861340604057201 GO:0004864 protein phosphatase inhibitor activity 7/2209 53/18639 0.132075471698113 1.11442042416529 0.441540413438291 0.872483856954063 GO:0005544 calcium-dependent phospholipid binding 7/2209 53/18639 0.132075471698113 1.11442042416529 0.441540413438291 0.872483856954063 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/2209 53/18639 0.132075471698113 1.11442042416529 0.441540413438291 0.872483856954063 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/2209 45/18639 0.133333333333333 1.12503395201449 0.445885411169984 0.876475451640847 GO:0141110 transporter inhibitor activity 6/2209 45/18639 0.133333333333333 1.12503395201449 0.445885411169984 0.876475451640847 GO:0004866 endopeptidase inhibitor activity 20/2209 161/18639 0.124223602484472 1.04816827827437 0.447107792673158 0.876475451640847 GO:0005178 integrin binding 20/2209 161/18639 0.124223602484472 1.04816827827437 0.447107792673158 0.876475451640847 GO:0022829 wide pore channel activity 5/2209 37/18639 0.135135135135135 1.1402371135282 0.450575030964621 0.876475451640847 GO:0016782 transferase activity, transferring sulphur-containing groups 9/2209 70/18639 0.128571428571429 1.08485416801397 0.451249062438612 0.876475451640847 GO:0008276 protein methyltransferase activity 12/2209 95/18639 0.126315789473684 1.06582163875057 0.453508353091436 0.876475451640847 GO:0003785 actin monomer binding 4/2209 29/18639 0.137931034482759 1.16382822622188 0.455678479350135 0.876475451640847 GO:0004629 phospholipase C activity 4/2209 29/18639 0.137931034482759 1.16382822622188 0.455678479350135 0.876475451640847 GO:0035250 UDP-galactosyltransferase activity 4/2209 29/18639 0.137931034482759 1.16382822622188 0.455678479350135 0.876475451640847 GO:0015179 L-amino acid transmembrane transporter activity 8/2209 62/18639 0.129032258064516 1.08874253420757 0.456200382462717 0.876475451640847 GO:0016922 nuclear receptor binding 17/2209 137/18639 0.124087591240876 1.04702064877261 0.458934902158335 0.876475451640847 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2209 21/18639 0.142857142857143 1.20539352001552 0.461240394006922 0.876475451640847 GO:0009975 cyclase activity 3/2209 21/18639 0.142857142857143 1.20539352001552 0.461240394006922 0.876475451640847 GO:0015174 basic amino acid transmembrane transporter activity 3/2209 21/18639 0.142857142857143 1.20539352001552 0.461240394006922 0.876475451640847 GO:0035613 RNA stem-loop binding 3/2209 21/18639 0.142857142857143 1.20539352001552 0.461240394006922 0.876475451640847 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/2209 21/18639 0.142857142857143 1.20539352001552 0.461240394006922 0.876475451640847 GO:0061891 calcium ion sensor activity 3/2209 21/18639 0.142857142857143 1.20539352001552 0.461240394006922 0.876475451640847 GO:0002161 aminoacyl-tRNA editing activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0003964 RNA-directed DNA polymerase activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0005172 vascular endothelial growth factor receptor binding 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0005542 folic acid binding 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0008417 fucosyltransferase activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0030955 potassium ion binding 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0031432 titin binding 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0061459 L-arginine transmembrane transporter activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0071714 icosanoid transmembrane transporter activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0071837 HMG box domain binding 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0140333 glycerophospholipid flippase activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/2209 13/18639 0.153846153846154 1.29811609847825 0.466980443060467 0.876475451640847 GO:0004197 cysteine-type endopeptidase activity 11/2209 88/18639 0.125 1.05471933001358 0.473912880744053 0.888137189254788 GO:0031210 phosphatidylcholine binding 4/2209 30/18639 0.133333333333333 1.12503395201449 0.482831326591802 0.902112992951399 GO:0033612 receptor serine/threonine kinase binding 4/2209 30/18639 0.133333333333333 1.12503395201449 0.482831326591802 0.902112992951399 GO:0005504 fatty acid binding 6/2209 47/18639 0.127659574468085 1.07716016682238 0.489277487335788 0.912775977129453 GO:0016757 glycosyltransferase activity 32/2209 267/18639 0.119850187265918 1.01126647372089 0.501477328904844 0.932098784360732 GO:0004065 arylsulfatase activity 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0004705 JUN kinase activity 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0005161 platelet-derived growth factor receptor binding 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0005545 1-phosphatidylinositol binding 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0008559 ABC-type xenobiotic transporter activity 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0030983 mismatched DNA binding 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0046030 inositol trisphosphate phosphatase activity 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0070742 C2H2 zinc finger domain binding 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0071933 Arp2/3 complex binding 2/2209 14/18639 0.142857142857143 1.20539352001552 0.507182496429483 0.932098784360732 GO:0072341 modified amino acid binding 11/2209 91/18639 0.120879120879121 1.01994836309006 0.520446880127551 0.953904787808279 GO:0005496 steroid binding 13/2209 108/18639 0.12037037037037 1.01565565112419 0.520592572455692 0.953904787808279 GO:0032451 demethylase activity 5/2209 40/18639 0.125 1.05471933001358 0.521616657056536 0.954365291058995 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/2209 23/18639 0.130434782608696 1.10057669218808 0.523943056991587 0.954380052189691 GO:0099186 structural constituent of postsynapse 3/2209 23/18639 0.130434782608696 1.10057669218808 0.523943056991587 0.954380052189691 GO:0140103 catalytic activity, acting on a glycoprotein 3/2209 23/18639 0.130434782608696 1.10057669218808 0.523943056991587 0.954380052189691 GO:0042910 xenobiotic transmembrane transporter activity 4/2209 32/18639 0.125 1.05471933001358 0.535381649045733 0.967677081717313 GO:0043425 bHLH transcription factor binding 4/2209 32/18639 0.125 1.05471933001358 0.535381649045733 0.967677081717313 GO:0051059 NF-kappaB binding 4/2209 32/18639 0.125 1.05471933001358 0.535381649045733 0.967677081717313 GO:0043178 alcohol binding 11/2209 92/18639 0.119565217391304 1.00886196783908 0.535687356962622 0.967677081717313 GO:0004674 protein serine/threonine kinase activity 51/2209 433/18639 0.117782909930716 0.993823294793397 0.541743159848658 0.967677081717313 GO:0140828 metal cation:monoatomic cation antiporter activity 5/2209 41/18639 0.121951219512195 1.02899446830593 0.544419581026729 0.967677081717313 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0010181 FMN binding 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0015116 sulfate transmembrane transporter activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0034483 heparan sulfate sulfotransferase activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0042809 nuclear vitamin D receptor binding 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0045504 dynein heavy chain binding 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0048531 beta-1,3-galactosyltransferase activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0050780 dopamine receptor binding 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0140776 protein-containing complex destabilizing activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0141050 histone H3K deacetylase activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0141051 histone H4K deacetylase activity 2/2209 15/18639 0.133333333333333 1.12503395201449 0.545346760222875 0.967677081717313 GO:0140789 histone phosphatase activity 16/2209 136/18639 0.117647058823529 0.99267701648337 0.552326677311815 0.97557067660166 GO:0015149 hexose transmembrane transporter activity 3/2209 24/18639 0.125 1.05471933001358 0.55374497513989 0.97557067660166 GO:0015295 solute:proton symporter activity 3/2209 24/18639 0.125 1.05471933001358 0.55374497513989 0.97557067660166 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2209 24/18639 0.125 1.05471933001358 0.55374497513989 0.97557067660166 GO:0055056 D-glucose transmembrane transporter activity 3/2209 24/18639 0.125 1.05471933001358 0.55374497513989 0.97557067660166 GO:0015171 amino acid transmembrane transporter activity 12/2209 102/18639 0.117647058823529 0.99267701648337 0.556683871761265 0.9793512558763 GO:0001786 phosphatidylserine binding 7/2209 59/18639 0.11864406779661 1.00108953357221 0.558783669949065 0.981646987748358 GO:0140311 protein sequestering activity 4/2209 33/18639 0.121212121212121 1.02275813819499 0.560628038184134 0.983488106757678 GO:0140223 general transcription initiation factor activity 8/2209 68/18639 0.117647058823529 0.99267701648337 0.564836341329344 0.988063571588867 GO:1990841 promoter-specific chromatin binding 8/2209 68/18639 0.117647058823529 0.99267701648337 0.564836341329344 0.988063571588867 GO:0004520 DNA endonuclease activity 5/2209 42/18639 0.119047619047619 1.00449460001293 0.566693229396739 0.988511494781035 GO:0035198 miRNA binding 5/2209 42/18639 0.119047619047619 1.00449460001293 0.566693229396739 0.988511494781035 GO:0005253 monoatomic anion channel activity 12/2209 103/18639 0.116504854368932 0.983039375546638 0.570868278888184 0.99072749476224 GO:0050660 flavin adenine dinucleotide binding 10/2209 86/18639 0.116279069767442 0.98113426047775 0.575521226677778 0.99072749476224 GO:0004867 serine-type endopeptidase inhibitor activity 11/2209 95/18639 0.115789473684211 0.977003168854685 0.580331929008739 0.99072749476224 GO:0004707 MAP kinase activity 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0005149 interleukin-1 receptor binding 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0008296 3'-5'-DNA exonuclease activity 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0016722 oxidoreductase activity, acting on metal ions 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0030275 LRR domain binding 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0055102 lipase inhibitor activity 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0140327 flippase activity 2/2209 16/18639 0.125 1.05471933001358 0.581391421414431 0.99072749476224 GO:0008139 nuclear localization sequence binding 3/2209 25/18639 0.12 1.01253055681304 0.582403369390596 0.99072749476224 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2209 25/18639 0.12 1.01253055681304 0.582403369390596 0.99072749476224 GO:0017025 TBP-class protein binding 3/2209 25/18639 0.12 1.01253055681304 0.582403369390596 0.99072749476224 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/2209 25/18639 0.12 1.01253055681304 0.582403369390596 0.99072749476224 GO:0019707 protein-cysteine S-acyltransferase activity 3/2209 25/18639 0.12 1.01253055681304 0.582403369390596 0.99072749476224 GO:0042974 nuclear retinoic acid receptor binding 3/2209 25/18639 0.12 1.01253055681304 0.582403369390596 0.99072749476224 GO:0070851 growth factor receptor binding 16/2209 139/18639 0.115107913669065 0.971252332674377 0.588989031303176 0.999999999999882 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2209 52/18639 0.115384615384615 0.97358707385869 0.591879941160787 0.999999999999882 GO:0005179 hormone activity 15/2209 132/18639 0.113636363636364 0.958835754557801 0.609393297074586 0.999999999999882 GO:0001046 core promoter sequence-specific DNA binding 5/2209 44/18639 0.113636363636364 0.958835754557801 0.609484468543977 0.999999999999882 GO:0001223 transcription coactivator binding 5/2209 44/18639 0.113636363636364 0.958835754557801 0.609484468543977 0.999999999999882 GO:0004435 phosphatidylinositol phospholipase C activity 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0015145 monosaccharide transmembrane transporter activity 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0030507 spectrin binding 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0034237 protein kinase A regulatory subunit binding 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0070412 R-SMAD binding 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0097602 cullin family protein binding 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0120014 phospholipid transfer activity 3/2209 26/18639 0.115384615384615 0.97358707385869 0.609862068830568 0.999999999999882 GO:0008146 sulfotransferase activity 6/2209 53/18639 0.113207547169811 0.955217506427394 0.611072221295574 0.999999999999882 GO:0017046 peptide hormone binding 6/2209 53/18639 0.113207547169811 0.955217506427394 0.611072221295574 0.999999999999882 GO:0051018 protein kinase A binding 6/2209 53/18639 0.113207547169811 0.955217506427394 0.611072221295574 0.999999999999882 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0008429 phosphatidylethanolamine binding 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0008484 sulfuric ester hydrolase activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0015278 intracellularly gated calcium channel activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0017110 nucleoside diphosphate phosphatase activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0030548 acetylcholine receptor regulator activity 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0031489 myosin V binding 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0046965 nuclear retinoid X receptor binding 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0070402 NADPH binding 2/2209 17/18639 0.117647058823529 0.99267701648337 0.615282654584631 0.999999999999882 GO:0008170 N-methyltransferase activity 11/2209 98/18639 0.112244897959184 0.947094908583624 0.62302398208575 0.999999999999882 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/2209 54/18639 0.111111111111111 0.937528293345405 0.629751870010507 0.999999999999882 GO:0140303 intramembrane lipid transporter activity 5/2209 45/18639 0.111111111111111 0.937528293345405 0.629934350715726 0.999999999999882 GO:0005385 zinc ion transmembrane transporter activity 3/2209 27/18639 0.111111111111111 0.937528293345405 0.636083408137554 0.999999999999882 GO:0023026 MHC class II protein complex binding 3/2209 27/18639 0.111111111111111 0.937528293345405 0.636083408137554 0.999999999999882 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2209 27/18639 0.111111111111111 0.937528293345405 0.636083408137554 0.999999999999882 GO:0106310 protein serine kinase activity 41/2209 361/18639 0.113573407202216 0.958304543613447 0.639844319427404 0.999999999999882 GO:0008525 phosphatidylcholine transporter activity 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:0016854 racemase and epimerase activity 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:0031690 adrenergic receptor binding 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:0035615 clathrin adaptor activity 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:0099602 neurotransmitter receptor regulator activity 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:1901611 phosphatidylglycerol binding 2/2209 18/18639 0.111111111111111 0.937528293345405 0.647024405176371 0.999999999999882 GO:0004536 DNA nuclease activity 7/2209 64/18639 0.109375 0.922879413761883 0.647264389852968 0.999999999999882 GO:0016758 hexosyltransferase activity 22/2209 197/18639 0.111675126903553 0.942287320215179 0.650225380594117 0.999999999999882 GO:0043394 proteoglycan binding 4/2209 37/18639 0.108108108108108 0.912189690822556 0.653533863811428 0.999999999999882 GO:0042578 phosphoric ester hydrolase activity 41/2209 363/18639 0.112947658402204 0.953024628772602 0.65414878164403 0.999999999999882 GO:0046966 nuclear thyroid hormone receptor binding 3/2209 28/18639 0.107142857142857 0.904045140011641 0.661045920284773 0.999999999999882 GO:0050698 proteoglycan sulfotransferase activity 3/2209 28/18639 0.107142857142857 0.904045140011641 0.661045920284773 0.999999999999882 GO:0051119 sugar transmembrane transporter activity 3/2209 28/18639 0.107142857142857 0.904045140011641 0.661045920284773 0.999999999999882 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/2209 28/18639 0.107142857142857 0.904045140011641 0.661045920284773 0.999999999999882 GO:0030165 PDZ domain binding 9/2209 83/18639 0.108433734939759 0.914937250132263 0.66256053561113 0.999999999999882 GO:0170055 lipid transmembrane transporter activity 6/2209 56/18639 0.107142857142857 0.904045140011641 0.665491447354837 0.999999999999882 GO:0031490 chromatin DNA binding 14/2209 128/18639 0.109375 0.922879413761883 0.666469718156944 0.999999999999882 GO:0043495 protein-membrane adaptor activity 5/2209 47/18639 0.106382978723404 0.897633472351984 0.668819039272707 0.999999999999882 GO:0140938 histone H3 methyltransferase activity 5/2209 47/18639 0.106382978723404 0.897633472351984 0.668819039272707 0.999999999999882 GO:0005501 retinoid binding 4/2209 38/18639 0.105263157894737 0.888184698958805 0.674581037626951 0.999999999999882 GO:0019840 isoprenoid binding 4/2209 38/18639 0.105263157894737 0.888184698958805 0.674581037626951 0.999999999999882 GO:0042887 amide transmembrane transporter activity 4/2209 38/18639 0.105263157894737 0.888184698958805 0.674581037626951 0.999999999999882 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0016918 retinal binding 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0031420 alkali metal ion binding 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0042800 histone H3K4 methyltransferase activity 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0141147 intracellularly calcium-gated channel activity 2/2209 19/18639 0.105263157894737 0.888184698958805 0.676649918735795 0.999999999999882 GO:0016417 S-acyltransferase activity 3/2209 29/18639 0.103448275862069 0.872871169666412 0.684742163469539 0.999999999999882 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/2209 29/18639 0.103448275862069 0.872871169666412 0.684742163469539 0.999999999999882 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 14/2209 130/18639 0.107692307692308 0.908681268934777 0.689178952968972 0.999999999999882 GO:0042562 hormone binding 10/2209 94/18639 0.106382978723404 0.897633472351984 0.689489871094313 0.999999999999882 GO:0042054 histone methyltransferase activity 7/2209 67/18639 0.104477611940299 0.881556454936724 0.694986681267378 0.999999999999882 GO:0061980 regulatory RNA binding 6/2209 58/18639 0.103448275862069 0.872871169666412 0.698973182815419 0.999999999999882 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/2209 20/18639 0.1 0.843775464010865 0.70421474606294 0.999999999999882 GO:0005326 neurotransmitter transmembrane transporter activity 2/2209 20/18639 0.1 0.843775464010865 0.70421474606294 0.999999999999882 GO:0015095 magnesium ion transmembrane transporter activity 2/2209 20/18639 0.1 0.843775464010865 0.70421474606294 0.999999999999882 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2209 20/18639 0.1 0.843775464010865 0.70421474606294 0.999999999999882 GO:0140664 ATP-dependent DNA damage sensor activity 2/2209 20/18639 0.1 0.843775464010865 0.70421474606294 0.999999999999882 GO:0140939 histone H4 methyltransferase activity 2/2209 20/18639 0.1 0.843775464010865 0.70421474606294 0.999999999999882 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0022839 monoatomic ion-gated channel activity 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0031624 ubiquitin conjugating enzyme binding 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0048019 receptor antagonist activity 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0051721 protein phosphatase 2A binding 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0098918 structural constituent of synapse 3/2209 30/18639 0.1 0.843775464010865 0.707176700900399 0.999999999999882 GO:0005548 phospholipid transporter activity 7/2209 68/18639 0.102941176470588 0.868592389422949 0.7099219661783 0.999999999999882 GO:0003714 transcription corepressor activity 22/2209 204/18639 0.107843137254902 0.909953931776423 0.713897795750332 0.999999999999882 GO:0015144 carbohydrate transmembrane transporter activity 4/2209 40/18639 0.1 0.843775464010865 0.713957510989248 0.999999999999882 GO:0071949 FAD binding 4/2209 40/18639 0.1 0.843775464010865 0.713957510989248 0.999999999999882 GO:0016407 acetyltransferase activity 10/2209 96/18639 0.104166666666667 0.878932775011317 0.714835812321015 0.999999999999882 GO:0000182 rDNA binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0004955 prostaglandin receptor activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0005337 nucleoside transmembrane transporter activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0005381 iron ion transmembrane transporter activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0008140 cAMP response element binding protein binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0008239 dipeptidyl-peptidase activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0015187 glycine transmembrane transporter activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0015203 polyamine transmembrane transporter activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0019531 oxalate transmembrane transporter activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0031419 cobalamin binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0032052 bile acid binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0035256 G protein-coupled glutamate receptor binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0035374 chondroitin sulfate binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0042975 peroxisome proliferator activated receptor binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0043208 glycosphingolipid binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0043295 glutathione binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0045322 unmethylated CpG binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0140999 histone H3K4 trimethyltransferase activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0141109 transporter activator activity 1/2209 10/18639 0.1 0.843775464010865 0.716855240491305 0.999999999999882 GO:0005319 lipid transporter activity 19/2209 178/18639 0.106741573033708 0.900659203157665 0.721043088136858 0.999999999999882 GO:0008013 beta-catenin binding 11/2209 106/18639 0.10377358490566 0.875616047558444 0.724916411628348 0.999999999999882 GO:0005164 tumor necrosis factor receptor binding 3/2209 31/18639 0.0967741935483871 0.816556900655675 0.728364243649206 0.999999999999882 GO:0005452 solute:inorganic anion antiporter activity 3/2209 31/18639 0.0967741935483871 0.816556900655675 0.728364243649206 0.999999999999882 GO:0008327 methyl-CpG binding 3/2209 31/18639 0.0967741935483871 0.816556900655675 0.728364243649206 0.999999999999882 GO:0016878 acid-thiol ligase activity 3/2209 31/18639 0.0967741935483871 0.816556900655675 0.728364243649206 0.999999999999882 GO:0047499 calcium-independent phospholipase A2 activity 3/2209 31/18639 0.0967741935483871 0.816556900655675 0.728364243649206 0.999999999999882 GO:0140457 protein demethylase activity 3/2209 31/18639 0.0967741935483871 0.816556900655675 0.728364243649206 0.999999999999882 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/2209 21/18639 0.0952380952380952 0.803595680010347 0.729790993647784 0.999999999999882 GO:0001846 opsonin binding 2/2209 21/18639 0.0952380952380952 0.803595680010347 0.729790993647784 0.999999999999882 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2209 21/18639 0.0952380952380952 0.803595680010347 0.729790993647784 0.999999999999882 GO:0008373 sialyltransferase activity 2/2209 21/18639 0.0952380952380952 0.803595680010347 0.729790993647784 0.999999999999882 GO:0051428 peptide hormone receptor binding 2/2209 21/18639 0.0952380952380952 0.803595680010347 0.729790993647784 0.999999999999882 GO:0140312 cargo adaptor activity 2/2209 21/18639 0.0952380952380952 0.803595680010347 0.729790993647784 0.999999999999882 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/2209 60/18639 0.1 0.843775464010865 0.730127720790428 0.999999999999882 GO:0004812 aminoacyl-tRNA ligase activity 4/2209 41/18639 0.0975609756097561 0.823195574644746 0.73228593585006 0.999999999999882 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/2209 41/18639 0.0975609756097561 0.823195574644746 0.73228593585006 0.999999999999882 GO:0042287 MHC protein binding 4/2209 41/18639 0.0975609756097561 0.823195574644746 0.73228593585006 0.999999999999882 GO:0033293 monocarboxylic acid binding 8/2209 79/18639 0.10126582278481 0.854456166086952 0.733431500749913 0.999999999999882 GO:0015291 secondary active transmembrane transporter activity 31/2209 287/18639 0.10801393728223 0.91139510049954 0.736735909783377 0.999999999999882 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 38/2209 349/18639 0.108882521489971 0.918724000928735 0.736806092879762 0.999999999999882 GO:0008028 monocarboxylic acid transmembrane transporter activity 7/2209 70/18639 0.1 0.843775464010865 0.738298618398671 0.999999999999882 GO:0042626 ATPase-coupled transmembrane transporter activity 10/2209 98/18639 0.102040816326531 0.860995371439658 0.738812035186264 0.999999999999882 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 19/2209 181/18639 0.104972375690608 0.885731150066653 0.747391756729581 0.999999999999882 GO:0015106 bicarbonate transmembrane transporter activity 3/2209 32/18639 0.09375 0.791039497510186 0.748327960332325 0.999999999999882 GO:0047498 calcium-dependent phospholipase A2 activity 3/2209 32/18639 0.09375 0.791039497510186 0.748327960332325 0.999999999999882 GO:0120015 sterol transfer activity 3/2209 32/18639 0.09375 0.791039497510186 0.748327960332325 0.999999999999882 GO:0008194 UDP-glycosyltransferase activity 15/2209 145/18639 0.103448275862069 0.872871169666412 0.750263818245597 0.999999999999882 GO:0004016 adenylate cyclase activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0004954 prostanoid receptor activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0005114 type II transforming growth factor beta receptor binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0008046 axon guidance receptor activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0008199 ferric iron binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0008432 JUN kinase binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0008526 phosphatidylinositol transfer activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0031731 CCR6 chemokine receptor binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0042608 T cell receptor binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0043522 leucine zipper domain binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0070697 activin receptor binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0097493 structural molecule activity conferring elasticity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0140031 phosphorylation-dependent protein binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0140537 transcription regulator activator activity 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:1900750 oligopeptide binding 1/2209 11/18639 0.0909090909090909 0.767068603646241 0.750430138432939 0.999999999999882 GO:0004407 histone deacetylase activity 2/2209 22/18639 0.0909090909090909 0.767068603646241 0.753462622666509 0.999999999999882 GO:0008093 cytoskeletal anchor activity 2/2209 22/18639 0.0909090909090909 0.767068603646241 0.753462622666509 0.999999999999882 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/2209 22/18639 0.0909090909090909 0.767068603646241 0.753462622666509 0.999999999999882 GO:0016881 acid-amino acid ligase activity 2/2209 22/18639 0.0909090909090909 0.767068603646241 0.753462622666509 0.999999999999882 GO:0031683 G-protein beta/gamma-subunit complex binding 2/2209 22/18639 0.0909090909090909 0.767068603646241 0.753462622666509 0.999999999999882 GO:0033558 protein lysine deacetylase activity 2/2209 22/18639 0.0909090909090909 0.767068603646241 0.753462622666509 0.999999999999882 GO:0030971 receptor tyrosine kinase binding 8/2209 81/18639 0.0987654320987654 0.833358482973693 0.758666386368031 0.999999999999882 GO:0005246 calcium channel regulator activity 5/2209 53/18639 0.0943396226415094 0.796014588689495 0.768594885095816 0.999999999999882 GO:0034212 protein N-acetyltransferase activity 5/2209 53/18639 0.0943396226415094 0.796014588689495 0.768594885095816 0.999999999999882 GO:0035591 signaling adaptor activity 13/2209 129/18639 0.10077519379845 0.850316359080716 0.772688301297129 0.999999999999882 GO:0005283 amino acid:sodium symporter activity 2/2209 23/18639 0.0869565217391304 0.733717794792056 0.775321628921264 0.999999999999882 GO:0016849 phosphorus-oxygen lyase activity 2/2209 23/18639 0.0869565217391304 0.733717794792056 0.775321628921264 0.999999999999882 GO:0031681 G-protein beta-subunit binding 2/2209 23/18639 0.0869565217391304 0.733717794792056 0.775321628921264 0.999999999999882 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2209 23/18639 0.0869565217391304 0.733717794792056 0.775321628921264 0.999999999999882 GO:0070577 lysine-acetylated histone binding 2/2209 23/18639 0.0869565217391304 0.733717794792056 0.775321628921264 0.999999999999882 GO:0071617 lysophospholipid acyltransferase activity 2/2209 23/18639 0.0869565217391304 0.733717794792056 0.775321628921264 0.999999999999882 GO:1902936 phosphatidylinositol bisphosphate binding 11/2209 111/18639 0.0990990990990991 0.83617388325401 0.778641018587585 0.999999999999882 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0004000 adenosine deaminase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0004032 aldose reductase (NADPH) activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0004126 cytidine deaminase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0004875 complement receptor activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0005025 transforming growth factor beta receptor activity, type I 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0005026 transforming growth factor beta receptor activity, type II 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0005078 MAP-kinase scaffold activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0005165 neurotrophin receptor binding 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0005247 voltage-gated chloride channel activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0015166 polyol transmembrane transporter activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0016361 activin receptor activity, type I 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0016362 activin receptor activity, type II 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0017002 activin receptor activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0034452 dynactin binding 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0035259 nuclear glucocorticoid receptor binding 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0042301 phosphate ion binding 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0097677 STAT family protein binding 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:1990459 transferrin receptor binding 1/2209 12/18639 0.0833333333333333 0.703146220009054 0.780025361978228 0.999999999999882 GO:0050661 NADP binding 5/2209 54/18639 0.0925925925925926 0.781273577787838 0.782762539696358 0.999999999999882 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/2209 34/18639 0.0882352941176471 0.744507762362528 0.784709891440702 0.999999999999882 GO:0051427 hormone receptor binding 3/2209 34/18639 0.0882352941176471 0.744507762362528 0.784709891440702 0.999999999999882 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/2209 34/18639 0.0882352941176471 0.744507762362528 0.784709891440702 0.999999999999882 GO:0051213 dioxygenase activity 9/2209 93/18639 0.0967741935483871 0.816556900655675 0.787378364129949 0.999999999999882 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0005315 phosphate transmembrane transporter activity 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0030215 semaphorin receptor binding 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0030552 cAMP binding 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0070840 dynein complex binding 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0140033 acetylation-dependent protein binding 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0140612 DNA damage sensor activity 2/2209 24/18639 0.0833333333333333 0.703146220009054 0.795464961083207 0.999999999999882 GO:0016410 N-acyltransferase activity 9/2209 94/18639 0.0957446808510638 0.807870125116785 0.797743028098428 0.999999999999882 GO:0004623 phospholipase A2 activity 3/2209 35/18639 0.0857142857142857 0.723236112009312 0.801203808266028 0.999999999999882 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0035325 Toll-like receptor binding 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0035673 oligopeptide transmembrane transporter activity 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0046975 histone H3K36 methyltransferase activity 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0070123 transforming growth factor beta receptor activity, type III 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0097157 pre-mRNA intronic binding 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0140852 histone ubiquitin ligase activity 1/2209 13/18639 0.0769230769230769 0.649058049239127 0.806112438554708 0.999999999999882 GO:0001848 complement binding 2/2209 25/18639 0.08 0.675020371208692 0.813992056012999 0.999999999999882 GO:0003707 nuclear steroid receptor activity 2/2209 25/18639 0.08 0.675020371208692 0.813992056012999 0.999999999999882 GO:0015645 fatty acid ligase activity 2/2209 25/18639 0.08 0.675020371208692 0.813992056012999 0.999999999999882 GO:0047617 fatty acyl-CoA hydrolase activity 2/2209 25/18639 0.08 0.675020371208692 0.813992056012999 0.999999999999882 GO:0120020 cholesterol transfer activity 2/2209 25/18639 0.08 0.675020371208692 0.813992056012999 0.999999999999882 GO:0120515 fatty acid-CoA ligase activity 2/2209 25/18639 0.08 0.675020371208692 0.813992056012999 0.999999999999882 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/2209 86/18639 0.0930232558139535 0.7849074083822 0.81416681776216 0.999999999999882 GO:0004033 aldo-keto reductase (NADPH) activity 3/2209 36/18639 0.0833333333333333 0.703146220009054 0.816623030074891 0.999999999999882 GO:0016409 palmitoyltransferase activity 3/2209 36/18639 0.0833333333333333 0.703146220009054 0.816623030074891 0.999999999999882 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/2209 67/18639 0.0895522388059701 0.755619818517192 0.820895946526407 0.999999999999882 GO:0001784 phosphotyrosine residue binding 4/2209 47/18639 0.0851063829787234 0.718106777881587 0.823980509142571 0.999999999999882 GO:0061733 protein-lysine-acetyltransferase activity 4/2209 47/18639 0.0851063829787234 0.718106777881587 0.823980509142571 0.999999999999882 GO:0140359 ABC-type transporter activity 4/2209 47/18639 0.0851063829787234 0.718106777881587 0.823980509142571 0.999999999999882 GO:0008081 phosphoric diester hydrolase activity 8/2209 87/18639 0.0919540229885057 0.775885484147921 0.823998317216966 0.999999999999882 GO:0140030 modification-dependent protein binding 17/2209 173/18639 0.0982658959537572 0.829143519548249 0.827365744477283 0.999999999999882 GO:0035402 histone H3T11 kinase activity 25/2209 247/18639 0.101214574898785 0.854023748998851 0.827409685923086 0.999999999999882 GO:0005313 L-glutamate transmembrane transporter activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0008392 arachidonate epoxygenase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0008474 palmitoyl-(protein) hydrolase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0008494 translation activator activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0016530 metallochaperone activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0019992 diacylglycerol binding 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0031404 chloride ion binding 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0032454 histone H3K9 demethylase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0061665 SUMO ligase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0098599 palmitoyl hydrolase activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0098821 BMP receptor activity 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:1901612 cardiolipin binding 1/2209 14/18639 0.0714285714285714 0.602696760007761 0.829107049487418 0.999999999999882 GO:0035091 phosphatidylinositol binding 29/2209 284/18639 0.102112676056338 0.861601706208277 0.829661961037704 0.999999999999882 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0005227 calcium-activated cation channel activity 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0008157 protein phosphatase 1 binding 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0016289 acyl-CoA hydrolase activity 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0030247 polysaccharide binding 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0051139 metal cation:proton antiporter activity 2/2209 26/18639 0.0769230769230769 0.649058049239127 0.831002888278202 0.999999999999882 GO:0023023 MHC protein complex binding 3/2209 37/18639 0.0810810810810811 0.684142268116917 0.831013250627549 0.999999999999882 GO:0030551 cyclic nucleotide binding 3/2209 37/18639 0.0810810810810811 0.684142268116917 0.831013250627549 0.999999999999882 GO:1990782 protein tyrosine kinase binding 11/2209 117/18639 0.094017094017094 0.793293171292266 0.832714847349414 0.999999999999882 GO:0004725 protein tyrosine phosphatase activity 9/2209 98/18639 0.0918367346938776 0.774895834295692 0.835451890332771 0.999999999999882 GO:0140693 molecular condensate scaffold activity 4/2209 48/18639 0.0833333333333333 0.703146220009054 0.83641318305294 0.999999999999882 GO:0008080 N-acetyltransferase activity 6/2209 69/18639 0.0869565217391304 0.733717794792056 0.841852035108831 0.999999999999882 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/2209 89/18639 0.0898876404494382 0.758449855290665 0.842444602835401 0.999999999999882 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/2209 89/18639 0.0898876404494382 0.758449855290665 0.842444602835401 0.999999999999882 GO:0015459 potassium channel regulator activity 5/2209 59/18639 0.0847457627118644 0.71506395255158 0.843689983737533 0.999999999999882 GO:0005044 scavenger receptor activity 2/2209 27/18639 0.0740740740740741 0.62501886223027 0.846596446689453 0.999999999999882 GO:0008395 steroid hydroxylase activity 2/2209 27/18639 0.0740740740740741 0.62501886223027 0.846596446689453 0.999999999999882 GO:0016405 CoA-ligase activity 2/2209 27/18639 0.0740740740740741 0.62501886223027 0.846596446689453 0.999999999999882 GO:0004089 carbonate dehydratase activity 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0004953 icosanoid receptor activity 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0008242 omega peptidase activity 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0015250 water channel activity 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0015929 hexosaminidase activity 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0050700 CARD domain binding 1/2209 15/18639 0.0666666666666667 0.562516976007243 0.849375641577742 0.999999999999882 GO:0140793 histone H2AXY142 phosphatase activity 8/2209 90/18639 0.0888888888888889 0.750022634676324 0.851075861402513 0.999999999999882 GO:0005543 phospholipid binding 52/2209 497/18639 0.104627766599598 0.882823423109959 0.851565661324123 0.999999999999882 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 24/2209 243/18639 0.0987654320987654 0.833358482973693 0.856083237252509 0.999999999999882 GO:0008509 monoatomic anion transmembrane transporter activity 14/2209 149/18639 0.0939597315436242 0.792809160815578 0.856377810484247 0.999999999999882 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/2209 39/18639 0.0769230769230769 0.649058049239127 0.856896584396903 0.999999999999882 GO:0032813 tumor necrosis factor receptor superfamily binding 4/2209 50/18639 0.08 0.675020371208692 0.859075905535276 0.999999999999882 GO:0019789 SUMO transferase activity 2/2209 28/18639 0.0714285714285714 0.602696760007761 0.860869564105198 0.999999999999882 GO:0045499 chemorepellent activity 2/2209 28/18639 0.0714285714285714 0.602696760007761 0.860869564105198 0.999999999999882 GO:0046943 carboxylic acid transmembrane transporter activity 18/2209 188/18639 0.0957446808510638 0.807870125116785 0.862373128211546 0.999999999999882 GO:0004676 3-phosphoinositide-dependent protein kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0004711 ribosomal protein S6 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0035175 histone H3S10 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0035979 histone H2AXS139 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0044022 histone H3S28 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0044023 histone H4S1 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0044024 histone H2AS1 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0044025 histone H2BS14 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0072354 histone H3T3 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0072371 histone H2AS121 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0072518 Rho-dependent protein serine/threonine kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0140823 histone H2BS36 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0140855 histone H3S57 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0140995 histone H2A kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0140997 histone H4 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0140998 histone H2B kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:1990244 histone H2AT120 kinase activity 24/2209 245/18639 0.0979591836734694 0.826555556582071 0.86613648437343 0.999999999999882 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0005024 transforming growth factor beta receptor activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0005521 lamin binding 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0008391 arachidonate monooxygenase activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0015385 sodium:proton antiporter activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0015562 efflux transmembrane transporter activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0019841 retinol binding 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0022841 potassium ion leak channel activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0034450 ubiquitin-ubiquitin ligase activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2209 16/18639 0.0625 0.52735966500679 0.867241256255296 0.999999999999882 GO:0005342 organic acid transmembrane transporter activity 18/2209 189/18639 0.0952380952380952 0.803595680010347 0.867934183097148 0.999999999999882 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/2209 40/18639 0.075 0.632831598008148 0.868486238997524 0.999999999999882 GO:0005272 sodium channel activity 4/2209 51/18639 0.0784313725490196 0.66178467765558 0.869365655665498 0.999999999999882 GO:0004677 DNA-dependent protein kinase activity 24/2209 246/18639 0.0975609756097561 0.823195574644746 0.870957838273871 0.999999999999882 GO:0140857 histone H3T45 kinase activity 24/2209 246/18639 0.0975609756097561 0.823195574644746 0.870957838273871 0.999999999999882 GO:0005416 amino acid:monoatomic cation symporter activity 2/2209 29/18639 0.0689655172413793 0.581914113110941 0.873916038226358 0.999999999999882 GO:0099604 ligand-gated calcium channel activity 2/2209 29/18639 0.0689655172413793 0.581914113110941 0.873916038226358 0.999999999999882 GO:0035403 histone H3T6 kinase activity 24/2209 247/18639 0.097165991902834 0.819862799038897 0.875644634939426 0.999999999999882 GO:0001540 amyloid-beta binding 7/2209 83/18639 0.0843373493975904 0.711617861213982 0.87565804022824 0.999999999999882 GO:0030159 signaling receptor complex adaptor activity 4/2209 52/18639 0.0769230769230769 0.649058049239127 0.879001605601338 0.999999999999882 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 22/2209 229/18639 0.0960698689956332 0.810613982892534 0.879228254129102 0.999999999999882 GO:0017080 sodium channel regulator activity 3/2209 41/18639 0.0731707317073171 0.617396680983559 0.879238894509165 0.999999999999882 GO:0004679 AMP-activated protein kinase activity 24/2209 248/18639 0.0967741935483871 0.816556900655675 0.88019869465507 0.999999999999882 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0005092 GDP-dissociation inhibitor activity 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0019198 transmembrane receptor protein phosphatase activity 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0036041 long-chain fatty acid binding 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0038191 neuropilin binding 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0045125 bioactive lipid receptor activity 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0045236 CXCR chemokine receptor binding 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0070403 NAD+ binding 1/2209 17/18639 0.0588235294117647 0.496338508241685 0.882988668859713 0.999999999999882 GO:0019955 cytokine binding 13/2209 144/18639 0.0902777777777778 0.761741738343142 0.88461805113007 0.999999999999882 GO:0042277 peptide binding 24/2209 249/18639 0.0963855421686747 0.813277555673123 0.884621912957363 0.999999999999882 GO:0035064 methylated histone binding 6/2209 74/18639 0.0810810810810811 0.684142268116917 0.885614786487275 0.999999999999882 GO:0001965 G-protein alpha-subunit binding 2/2209 30/18639 0.0666666666666667 0.562516976007243 0.885825990892498 0.999999999999882 GO:0032452 histone demethylase activity 2/2209 30/18639 0.0666666666666667 0.562516976007243 0.885825990892498 0.999999999999882 GO:0070566 adenylyltransferase activity 2/2209 30/18639 0.0666666666666667 0.562516976007243 0.885825990892498 0.999999999999882 GO:0051020 GTPase binding 31/2209 315/18639 0.0984126984126984 0.830382202677359 0.887336045515024 0.999999999999882 GO:0004402 histone acetyltransferase activity 3/2209 42/18639 0.0714285714285714 0.602696760007761 0.889202136620972 0.999999999999882 GO:1901981 phosphatidylinositol phosphate binding 17/2209 185/18639 0.0918918918918919 0.775361237199173 0.896001912501335 0.999999999999882 GO:0005184 neuropeptide hormone activity 2/2209 31/18639 0.0645161290322581 0.544371267103784 0.896685421736863 0.999999999999882 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/2209 31/18639 0.0645161290322581 0.544371267103784 0.896685421736863 0.999999999999882 GO:0016411 acylglycerol O-acyltransferase activity 2/2209 31/18639 0.0645161290322581 0.544371267103784 0.896685421736863 0.999999999999882 GO:0072349 modified amino acid transmembrane transporter activity 2/2209 31/18639 0.0645161290322581 0.544371267103784 0.896685421736863 0.999999999999882 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2209 18/18639 0.0555555555555556 0.468764146672703 0.896868919664615 0.999999999999882 GO:0005372 water transmembrane transporter activity 1/2209 18/18639 0.0555555555555556 0.468764146672703 0.896868919664615 0.999999999999882 GO:0015172 acidic amino acid transmembrane transporter activity 1/2209 18/18639 0.0555555555555556 0.468764146672703 0.896868919664615 0.999999999999882 GO:0015280 ligand-gated sodium channel activity 1/2209 18/18639 0.0555555555555556 0.468764146672703 0.896868919664615 0.999999999999882 GO:0017128 phospholipid scramblase activity 1/2209 18/18639 0.0555555555555556 0.468764146672703 0.896868919664615 0.999999999999882 GO:0120013 lipid transfer activity 5/2209 65/18639 0.0769230769230769 0.649058049239127 0.897439897971156 0.999999999999882 GO:0160215 deacylase activity 5/2209 65/18639 0.0769230769230769 0.649058049239127 0.897439897971156 0.999999999999882 GO:0008375 acetylglucosaminyltransferase activity 3/2209 43/18639 0.0697674418604651 0.58868055628665 0.898422595648093 0.999999999999882 GO:0140034 methylation-dependent protein binding 6/2209 76/18639 0.0789473684210526 0.666138524219104 0.900002338219015 0.999999999999882 GO:0008374 O-acyltransferase activity 4/2209 55/18639 0.0727272727272727 0.613654882916992 0.904292234039763 0.999999999999882 GO:0008234 cysteine-type peptidase activity 17/2209 187/18639 0.0909090909090909 0.767068603646241 0.904950103119612 0.999999999999882 GO:0031406 carboxylic acid binding 17/2209 187/18639 0.0909090909090909 0.767068603646241 0.904950103119612 0.999999999999882 GO:0160041 neuropeptide activity 2/2209 32/18639 0.0625 0.52735966500679 0.906575919163832 0.999999999999882 GO:0016790 thiolester hydrolase activity 3/2209 44/18639 0.0681818181818182 0.57530145273468 0.906945675498131 0.999999999999882 GO:0043395 heparan sulfate proteoglycan binding 1/2209 19/18639 0.0526315789473684 0.444092349479402 0.909103308605105 0.999999999999882 GO:1990380 K48-linked deubiquitinase activity 1/2209 19/18639 0.0526315789473684 0.444092349479402 0.909103308605105 0.999999999999882 GO:0004620 phospholipase activity 9/2209 109/18639 0.0825688073394495 0.696695337256677 0.911200449958053 0.999999999999882 GO:0046982 protein heterodimerization activity 36/2209 369/18639 0.0975609756097561 0.823195574644746 0.912648124433625 0.999999999999882 GO:0043177 organic acid binding 17/2209 189/18639 0.0899470899470899 0.758951475565328 0.913259810038044 0.999999999999882 GO:0042605 peptide antigen binding 3/2209 45/18639 0.0666666666666667 0.562516976007243 0.914815339961364 0.999999999999882 GO:0019239 deaminase activity 2/2209 33/18639 0.0606060606060606 0.511379069097494 0.915574497655231 0.999999999999882 GO:0019956 chemokine binding 2/2209 33/18639 0.0606060606060606 0.511379069097494 0.915574497655231 0.999999999999882 GO:0030296 protein tyrosine kinase activator activity 2/2209 33/18639 0.0606060606060606 0.511379069097494 0.915574497655231 0.999999999999882 GO:0001972 retinoic acid binding 1/2209 20/18639 0.05 0.421887732005432 0.919886917159956 0.999999999999882 GO:0015464 acetylcholine receptor activity 1/2209 20/18639 0.05 0.421887732005432 0.919886917159956 0.999999999999882 GO:0030627 pre-mRNA 5'-splice site binding 1/2209 20/18639 0.05 0.421887732005432 0.919886917159956 0.999999999999882 GO:0004180 carboxypeptidase activity 3/2209 46/18639 0.0652173913043478 0.550288346094042 0.922073948958835 0.999999999999882 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/2209 46/18639 0.0652173913043478 0.550288346094042 0.922073948958835 0.999999999999882 GO:0016279 protein-lysine N-methyltransferase activity 5/2209 69/18639 0.072463768115942 0.611431495660047 0.923648780301138 0.999999999999882 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/2209 91/18639 0.0769230769230769 0.649058049239127 0.925662989003962 0.999999999999882 GO:0016278 lysine N-methyltransferase activity 5/2209 70/18639 0.0714285714285714 0.602696760007761 0.929194058176194 0.999999999999882 GO:0005248 voltage-gated sodium channel activity 1/2209 21/18639 0.0476190476190476 0.401797840005174 0.929391713335565 0.999999999999882 GO:0036122 BMP binding 1/2209 21/18639 0.0476190476190476 0.401797840005174 0.929391713335565 0.999999999999882 GO:0003730 mRNA 3'-UTR binding 24/2209 262/18639 0.0916030534351145 0.772924089170258 0.931180725198194 0.999999999999882 GO:0005343 organic acid:sodium symporter activity 2/2209 35/18639 0.0571428571428571 0.482157408006208 0.931180791742283 0.999999999999882 GO:0033691 sialic acid binding 1/2209 22/18639 0.0454545454545455 0.38353430182312 0.93776928908171 0.999999999999882 GO:0050321 tau-protein kinase activity 1/2209 22/18639 0.0454545454545455 0.38353430182312 0.93776928908171 0.999999999999882 GO:0004190 aspartic-type endopeptidase activity 2/2209 36/18639 0.0555555555555556 0.468764146672703 0.93791948360507 0.999999999999882 GO:0015293 symporter activity 12/2209 146/18639 0.0821917808219178 0.69351408000893 0.938341344024618 0.999999999999882 GO:0005254 chloride channel activity 6/2209 83/18639 0.072289156626506 0.609958166754842 0.938759546003205 0.999999999999882 GO:0042379 chemokine receptor binding 5/2209 72/18639 0.0694444444444444 0.585955183340878 0.939218092694728 0.999999999999882 GO:0005126 cytokine receptor binding 25/2209 275/18639 0.0909090909090909 0.767068603646241 0.94021516062485 0.999999999999882 GO:0035254 glutamate receptor binding 3/2209 49/18639 0.0612244897959184 0.516597222863795 0.940580708463862 0.999999999999882 GO:0019905 syntaxin binding 4/2209 61/18639 0.0655737704918033 0.553295386236633 0.941238463546376 0.999999999999882 GO:0015294 solute:monoatomic cation symporter activity 9/2209 116/18639 0.0775862068965517 0.654653377249809 0.942042199449525 0.999999999999882 GO:0016247 channel regulator activity 14/2209 168/18639 0.0833333333333333 0.703146220009054 0.943782024496805 0.999999999999882 GO:0019213 deacetylase activity 2/2209 37/18639 0.0540540540540541 0.456094845411278 0.944028411203786 0.999999999999882 GO:0070001 aspartic-type peptidase activity 2/2209 37/18639 0.0540540540540541 0.456094845411278 0.944028411203786 0.999999999999882 GO:0000149 SNARE binding 8/2209 106/18639 0.0754716981132075 0.636811670951596 0.944238115762732 0.999999999999882 GO:0004497 monooxygenase activity 8/2209 106/18639 0.0754716981132075 0.636811670951596 0.944238115762732 0.999999999999882 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/2209 23/18639 0.0434782608695652 0.366858897396028 0.945153273634458 0.999999999999882 GO:0005212 structural constituent of eye lens 1/2209 23/18639 0.0434782608695652 0.366858897396028 0.945153273634458 0.999999999999882 GO:0016493 C-C chemokine receptor activity 1/2209 23/18639 0.0434782608695652 0.366858897396028 0.945153273634458 0.999999999999882 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/2209 23/18639 0.0434782608695652 0.366858897396028 0.945153273634458 0.999999999999882 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/2209 23/18639 0.0434782608695652 0.366858897396028 0.945153273634458 0.999999999999882 GO:0048020 CCR chemokine receptor binding 3/2209 50/18639 0.06 0.506265278406519 0.945783142693346 0.999999999999882 GO:0141108 transporter regulator activity 14/2209 170/18639 0.0823529411764706 0.694873911538359 0.949503112734982 0.999999999999882 GO:0004622 lysophospholipase activity 1/2209 24/18639 0.0416666666666667 0.351573110004527 0.951661461136686 0.999999999999882 GO:0019957 C-C chemokine binding 1/2209 24/18639 0.0416666666666667 0.351573110004527 0.951661461136686 0.999999999999882 GO:0035035 histone acetyltransferase binding 1/2209 24/18639 0.0416666666666667 0.351573110004527 0.951661461136686 0.999999999999882 GO:0016298 lipase activity 10/2209 130/18639 0.0769230769230769 0.649058049239127 0.953295250911831 0.999999999999882 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/2209 130/18639 0.0769230769230769 0.649058049239127 0.953295250911831 0.999999999999882 GO:0000030 mannosyltransferase activity 1/2209 25/18639 0.04 0.337510185604346 0.957397686350173 0.999999999999882 GO:0005251 delayed rectifier potassium channel activity 1/2209 25/18639 0.04 0.337510185604346 0.957397686350173 0.999999999999882 GO:0015271 outward rectifier potassium channel activity 1/2209 25/18639 0.04 0.337510185604346 0.957397686350173 0.999999999999882 GO:0017056 structural constituent of nuclear pore 1/2209 25/18639 0.04 0.337510185604346 0.957397686350173 0.999999999999882 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/2209 25/18639 0.04 0.337510185604346 0.957397686350173 0.999999999999882 GO:0071855 neuropeptide receptor binding 2/2209 40/18639 0.05 0.421887732005432 0.959101843828075 0.999999999999882 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 9/2209 122/18639 0.0737704918032787 0.622457309516212 0.960550048150292 0.999999999999882 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2209 26/18639 0.0384615384615385 0.324529024619563 0.962453478273052 0.999999999999882 GO:0004950 chemokine receptor activity 1/2209 26/18639 0.0384615384615385 0.324529024619563 0.962453478273052 0.999999999999882 GO:0005112 Notch binding 1/2209 26/18639 0.0384615384615385 0.324529024619563 0.962453478273052 0.999999999999882 GO:0043548 phosphatidylinositol 3-kinase binding 1/2209 26/18639 0.0384615384615385 0.324529024619563 0.962453478273052 0.999999999999882 GO:0052742 phosphatidylinositol kinase activity 1/2209 26/18639 0.0384615384615385 0.324529024619563 0.962453478273052 0.999999999999882 GO:0001664 G protein-coupled receptor binding 26/2209 297/18639 0.0875420875420875 0.738658655363047 0.964833994725329 0.999999999999882 GO:0005104 fibroblast growth factor receptor binding 1/2209 27/18639 0.037037037037037 0.312509431115135 0.966909517949344 0.999999999999882 GO:0035255 ionotropic glutamate receptor binding 1/2209 27/18639 0.037037037037037 0.312509431115135 0.966909517949344 0.999999999999882 GO:0005085 guanyl-nucleotide exchange factor activity 19/2209 230/18639 0.0826086956521739 0.697031905052453 0.969022006203244 0.999999999999882 GO:0101005 deubiquitinase activity 8/2209 115/18639 0.0695652173913043 0.586974235833645 0.969743768621846 0.999999999999882 GO:0051959 dynein light intermediate chain binding 1/2209 28/18639 0.0357142857142857 0.30134838000388 0.970836923647276 0.999999999999882 GO:0141052 histone H3 demethylase activity 1/2209 28/18639 0.0357142857142857 0.30134838000388 0.970836923647276 0.999999999999882 GO:0019783 ubiquitin-like protein peptidase activity 9/2209 127/18639 0.0708661417322835 0.597951116228172 0.971721372777821 0.999999999999882 GO:0099106 ion channel regulator activity 12/2209 160/18639 0.075 0.632831598008148 0.972883669549276 0.999999999999882 GO:0004181 metallocarboxypeptidase activity 1/2209 29/18639 0.0344827586206897 0.290957056555471 0.97429838384088 0.999999999999882 GO:0005125 cytokine activity 19/2209 234/18639 0.0811965811965812 0.685116829752412 0.974808006175612 0.999999999999882 GO:0008009 chemokine activity 2/2209 45/18639 0.0444444444444444 0.375011317338162 0.97596920298763 0.999999999999882 GO:0004896 cytokine receptor activity 6/2209 96/18639 0.0625 0.52735966500679 0.977061766767181 0.999999999999882 GO:0030276 clathrin binding 2/2209 46/18639 0.0434782608695652 0.366858897396028 0.978418987261666 0.999999999999882 GO:0001217 DNA-binding transcription repressor activity 23/2209 278/18639 0.0827338129496403 0.698087614109708 0.978873481300567 0.999999999999882 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 22/2209 268/18639 0.082089552238806 0.692651500307426 0.978982997635087 0.999999999999882 GO:0099095 ligand-gated monoatomic anion channel activity 2/2209 47/18639 0.0425531914893617 0.359053388940793 0.980625958338309 0.999999999999882 GO:0015026 coreceptor activity 3/2209 61/18639 0.0491803278688525 0.414971539677474 0.980895428483501 0.999999999999882 GO:0008188 neuropeptide receptor activity 2/2209 48/18639 0.0416666666666667 0.351573110004527 0.982613228916662 0.999999999999882 GO:0038187 pattern recognition receptor activity 2/2209 48/18639 0.0416666666666667 0.351573110004527 0.982613228916662 0.999999999999882 GO:0015085 calcium ion transmembrane transporter activity 10/2209 147/18639 0.0680272108843537 0.573996914293105 0.984640060279256 0.999999999999882 GO:0015020 glucuronosyltransferase activity 1/2209 34/18639 0.0294117647058824 0.248169254120843 0.986336914880485 0.999999999999882 GO:0140767 enzyme-substrate adaptor activity 9/2209 139/18639 0.0647482014388489 0.546329437129337 0.987799269604873 0.999999999999882 GO:0015370 solute:sodium symporter activity 4/2209 79/18639 0.0506329113924051 0.427228083043476 0.987936558897298 0.999999999999882 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/2209 36/18639 0.0277777777777778 0.234382073336351 0.989388858658922 0.999999999999882 GO:0005484 SNAP receptor activity 1/2209 36/18639 0.0277777777777778 0.234382073336351 0.989388858658922 0.999999999999882 GO:0045505 dynein intermediate chain binding 1/2209 36/18639 0.0277777777777778 0.234382073336351 0.989388858658922 0.999999999999882 GO:0015081 sodium ion transmembrane transporter activity 11/2209 164/18639 0.0670731707317073 0.565946957568263 0.989712065847874 0.999999999999882 GO:0015103 inorganic anion transmembrane transporter activity 11/2209 165/18639 0.0666666666666667 0.562516976007243 0.990395535812873 0.999999999999882 GO:0031267 small GTPase binding 22/2209 283/18639 0.0777385159010601 0.655938523259329 0.990420547970673 0.999999999999882 GO:0004843 cysteine-type deubiquitinase activity 6/2209 108/18639 0.0555555555555556 0.468764146672703 0.991343588948501 0.999999999999882 GO:0015108 chloride transmembrane transporter activity 7/2209 121/18639 0.0578512396694215 0.488134565956699 0.991914967310859 0.999999999999882 GO:0060589 nucleoside-triphosphatase regulator activity 42/2209 490/18639 0.0857142857142857 0.723236112009312 0.992596790051504 0.999999999999882 GO:0001216 DNA-binding transcription activator activity 42/2209 491/18639 0.0855397148676171 0.721763126037807 0.992913273722719 0.999999999999882 GO:0099094 ligand-gated monoatomic cation channel activity 8/2209 136/18639 0.0588235294117647 0.496338508241685 0.993635313321515 0.999999999999882 GO:0005096 GTPase activator activity 20/2209 271/18639 0.0738007380073801 0.622712519565214 0.994229333463156 0.999999999999882 GO:0001727 lipid kinase activity 1/2209 41/18639 0.024390243902439 0.205798893661187 0.99436050311922 0.999999999999882 GO:0030695 GTPase regulator activity 41/2209 489/18639 0.0838445807770961 0.707460000499907 0.995024489901686 0.999999999999882 GO:0016755 aminoacyltransferase activity 41/2209 496/18639 0.0826612903225806 0.697475685976723 0.996395992273073 0.999999999999882 GO:0019787 ubiquitin-like protein transferase activity 39/2209 479/18639 0.081419624217119 0.686998812033898 0.996893655726299 0.999999999999882 GO:0004842 ubiquitin-protein transferase activity 36/2209 449/18639 0.0801781737193764 0.676523757336105 0.996958653315067 0.999999999999882 GO:0008528 G protein-coupled peptide receptor activity 6/2209 122/18639 0.0491803278688525 0.414971539677474 0.997401790903101 0.999999999999882 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 39/2209 484/18639 0.0805785123966942 0.679901716868259 0.997561741213172 0.999999999999882 GO:0016597 amino acid binding 1/2209 51/18639 0.0196078431372549 0.165446169413895 0.998407935011397 0.999999999999882 GO:0001653 peptide receptor activity 6/2209 128/18639 0.046875 0.395519748755093 0.998477391500247 0.999999999999882 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/2209 53/18639 0.0188679245283019 0.159202917737899 0.998763861654145 0.999999999999882 GO:0005262 calcium channel activity 6/2209 131/18639 0.0458015267175573 0.386462044585129 0.99883877244661 0.999999999999882 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/2209 56/18639 0.0178571428571429 0.15067419000194 0.999154326209305 0.999999999999882 GO:0015276 ligand-gated monoatomic ion channel activity 10/2209 186/18639 0.0537634408602151 0.453642722586486 0.999172703905442 0.999999999999882 GO:0022834 ligand-gated channel activity 10/2209 188/18639 0.0531914893617021 0.448816736175992 0.999295812345875 0.999999999999882 GO:0005249 voltage-gated potassium channel activity 3/2209 98/18639 0.0306122448979592 0.258298611431897 0.999582082136871 0.999999999999882 GO:0140375 immune receptor activity 7/2209 156/18639 0.0448717948717949 0.378617195389491 0.999595063156738 0.999999999999882 GO:0022824 transmitter-gated monoatomic ion channel activity 1/2209 63/18639 0.0158730158730159 0.133932613335058 0.999651334193905 0.999999999999882 GO:0022835 transmitter-gated channel activity 1/2209 63/18639 0.0158730158730159 0.133932613335058 0.999651334193905 0.999999999999882 GO:0061659 ubiquitin-like protein ligase activity 25/2209 372/18639 0.0672043010752688 0.567053403233108 0.999667084447795 0.999999999999882 GO:0022836 gated channel activity 20/2209 318/18639 0.0628930817610063 0.530676392459663 0.999709349640136 0.999999999999882 GO:0005244 voltage-gated monoatomic ion channel activity 8/2209 173/18639 0.046242774566474 0.390185185669764 0.999709657808424 0.999999999999882 GO:0061630 ubiquitin protein ligase activity 23/2209 353/18639 0.0651558073654391 0.549768715927759 0.999730041837044 0.999999999999882 GO:0022832 voltage-gated channel activity 8/2209 175/18639 0.0457142857142857 0.385725926404967 0.999756669695576 0.999999999999882 GO:0098960 postsynaptic neurotransmitter receptor activity 1/2209 69/18639 0.0144927536231884 0.122286299132009 0.999836896493989 0.999999999999882 GO:0005267 potassium channel activity 4/2209 124/18639 0.032258064516129 0.272185633551892 0.999858775760058 0.999999999999882 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/2209 73/18639 0.0136986301369863 0.115585680001488 0.999901726570531 0.999999999999882 GO:0030527 structural constituent of chromatin 2/2209 98/18639 0.0204081632653061 0.172199074287932 0.999941106795253 0.999999999999882 GO:0005216 monoatomic ion channel activity 27/2209 448/18639 0.0602678571428571 0.508525391256548 0.999990581960505 0.999999999999882 GO:0030594 neurotransmitter receptor activity 1/2209 97/18639 0.0103092783505155 0.0869871612382335 0.999995309590007 0.999999999999882 GO:0003823 antigen binding 5/2209 174/18639 0.028735632183908 0.242464213796225 0.999996054948943 0.999999999999882 GO:0046873 metal ion transmembrane transporter activity 26/2209 450/18639 0.0577777777777778 0.487514712539611 0.999996439698678 0.999999999999882 GO:0015079 potassium ion transmembrane transporter activity 4/2209 160/18639 0.025 0.210943866002716 0.999996979743107 0.999999999999882 GO:0022843 voltage-gated monoatomic cation channel activity 3/2209 143/18639 0.020979020979021 0.177015831610671 0.999997182787894 0.999999999999882 GO:0005261 monoatomic cation channel activity 14/2209 341/18639 0.0410557184750733 0.346418079066044 0.99999987968749 0.999999999999882 GO:0045182 translation regulator activity 10/2209 356/18639 0.0280898876404494 0.237015579778333 0.999999999905017 0.999999999999882 GO:0030371 translation repressor activity 5/2209 329/18639 0.0151975683890578 0.128233353193141 0.999999999999882 0.999999999999882