category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	88/1729	158/9376	3.02028684173921	CCNE1/CCNB1/PTTG1/CDC20/CCNB2/CCNA2/CDK1/AURKB/MAD2L1/PLK1/DBF4/SMC1A/ANAPC11/YWHAQ/BUB3/CDCA5/YWHAB/NDC80/FBXO5/TFDP1/RAD21/BUB1/ORC6/TTK/CDT1/CDC25C/ANAPC5/PRKDC/CDC25A/E2F5/CHEK1/ESCO2/CDC6/BUB1B/HDAC1/TRIP13/PPP2R1A/CHEK2/YWHAE/CDC25B/CDK4/MCM7/PPP2R5C/PDS5B/CDC27/CDC45/TICRR/E2F1/PKMYT1/CDC14B/ORC1/HDAC2/TGFB1/CCND3/E2F2/PPP2R1B/ANAPC7/ABL1/CDKN1B/CDC26/SMC3/MCM5/E2F3/ANAPC10/ATRX/DDX11/CUL1/PDS5A/ORC2/MCM6/MAD2L2/STAG2/RBL1/ESPL1/CDC7/NIPBL/ANAPC1/MYC/CCNH/MTBP/ATM/STAG1/CCNE2/ORC4/ORC5/CCND2/CDC16/CDKN2C	12.1775751001707
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	61/1729	108/9376	3.06287085234454	KPNA2/RBM8A/RAN/KPNB1/ALYREF/IPO5/NUP37/CSE1L/PNN/XPO1/UPF3B/SUMO2/IPO7/EIF4A3/MAGOHB/NCBP2/SEH1L/NDC1/THOC1/NUP62/NUP88/THOC2/THOC3/NUP205/RAE1/NUP54/NUP210/NUP50/ACIN1/TNPO3/SEC13/IPO9/POM121/POM121C/NUP155/NMD3/NUP153/NUP98/NUP160/AHCTF1/CASC3/NCBP1/NUP107/RANGAP1/KPNA4/TNPO1/PHAX/THOC5/NUP188/DDX39B/AAAS/TMEM33/NUP43/IPO4/NUP35/XPO7/XPO5/RANBP2/IPO8/RANBP17/XPO4	10.2524696987955
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	25/1729	36/9376	3.7658248184564	RNASEH2C/SSBP1/RNASEH2A/POLD2/RPA3/POLE4/RNASEH1/FEN1/PRIM1/POLA2/RFC4/MCM7/RNASEH2B/RFC3/RFC5/RFC2/LIG1/DNA2/POLD1/RPA2/POLE/POLE2/MCM5/POLD3/MCM6	7.90569529144802
Genetic Information Processing	Translation	hsa03010	Ribosome	82/1729	222/9376	2.00301168722221	MRPL23/MRPS15/RPL36/RPS9/RPSA/RPL29/RPL5/RPS5/RPL28/RPL7A/RPL15/RPS6/RPL19/RPS15/RPL18A/RPLP0/RPS3A/RPL8/RPS18/MRPL41/MRPL11/RPL6/RPL14/RPL22L1/RPL13A/RPL4/RPS13/RPS19/RPL3/MRPS16/RPS7/MRPL51/RPL35A/MRPL4/RPL22/MRPS9/MRPL37/MRPL3/MRPL12/MRPS5/MRPS12/MRPS35/MRPL32/MRPL47/MRPL52/MRPS27/MRPS2/MRPS14/MRPL35/MRPL40/MRPL14/MRPS7/MRPS22/MRPL20/MRPS31/MRPL22/RSL24D1/MRPL50/MRPL21/MRPS25/MRPL9/MRPL42/MRPL19/MRPL18/RPL26L1/MRPS6/MRPS30/MRPL15/MRPL45/MRPL36/MRPL24/DAP3/MRPL16/MRPL13/MRPS26/MRPL2/MRPL54/MRPL39/MRPS18A/MRPS23/MRPL28/MRPL49	7.19141938505796
Genetic Information Processing	Transcription	hsa03040	Spliceosome	85/1729	243/9376	1.89685990855582	SRSF3/RBM8A/HNRNPA3/SRSF7/LSM4/HNRNPA1/TXNL4A/SRSF2/HNRNPC/HSPA8/SNRPD1/HNRNPM/RBMX/ALYREF/SNRPA/HNRNPU/LSM5/FUS/SNRPF/SNRPE/LSM7/SRSF9/LSM2/SNRPD2/U2AF1/SRSF5/SRSF1/SNRPB/PRPF40A/PPIH/SNRNP70/RBM25/TRA2B/DDX5/SNRPG/TRA2A/SRSF6/SF3B5/EIF4A3/MAGOHB/SRSF4/HNRNPK/SNRNP40/LSM6/SRSF10/LSM3/NCBP2/U2SURP/PRPF38B/DDX46/PRPF4/SNRPD3/PPIL1/THOC1/RBM17/PUF60/BCAS2/TCERG1/THOC2/THOC3/SF3B1/PRPF38A/RBMX2/SF1/HNRNPA1L2/RBM22/U2AF2/PRPF19/SF3A3/PRPF31/ACIN1/PLRG1/CASC3/NCBP1/PQBP1/RBMXL1/DDX23/WBP11/THOC5/DDX39B/DHX15/PRPF8/EFTUD2/SF3B3/SNRNP200	6.73532580224324
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	50/1729	116/9376	2.33740850800742	PKM/ENO1/PHGDH/ACAT2/TPI1/GAPDH/ACAT1/GPI/PGAM1/PGLS/PCCA/MDH2/PGK1/RPIA/SHMT1/GPT2/PRPS2/IDH3G/FH/TKT/MDH1/SUCLG2/ESD/SHMT2/CS/SDHA/PCCB/ADH5/PGP/IDH3A/HK1/PDHB/ACSS2/PFKL/PC/DLD/G6PD/SDHB/GOT1/DLAT/PSPH/GLDC/PSAT1/PRPS1/RPE/SUCLA2/GLYCTK/DLST/ACO2/PFKP	6.89168109404442
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	65/1729	174/9376	2.0257540402731	HSPA5/PDIA6/CALR/HSP90AB1/SSR4/OSTC/LMAN1/HSP90B1/HSPA8/SSR3/HSP90AA1/PDIA4/CANX/MAN1A2/STT3B/PDIA3/CRYAB/SAR1A/RRBP1/UBXN4/DNAJB11/LMAN2/P4HB/EIF2S1/RPN2/SSR2/SEC61G/SEC61B/GANAB/HSPBP1/XBP1/SSR1/UBE2D2/ERP29/PRKCSH/DNAJC3/SAR1B/STT3A/SEC61A1/DNAJC10/MAGT1/BAK1/CKAP4/DAD1/KRTCAP2/DERL2/UBE2J2/DERL1/SEC63/SEC13/UGGT1/RPN1/UBE2G2/HYOU1/CUL1/ERN1/PLAA/ATXN3/SEC23B/NGLY1/UBE4B/DNAJC1/BCAP29/UBE2G1/EDEM2	6.49403067440293
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	44/1729	103/9376	2.31653068444075	RBM8A/PPP1CC/PABPC4/ALYREF/FUS/PPP1CB/PPP1CA/PNN/PAPOLA/DAZAP1/PABPC1/GSPT1/UPF3B/EIF4A3/MAGOHB/NCBP2/ETF1/PPP2R1A/CPSF6/PABPN1/TARDBP/MSI2/PPP2R5C/FIP1L1/WDR33/NUDT21/PPP2R1B/CPSF3/ACIN1/CASC3/NCBP1/DDX39B/CSTF1/SMG6/CPSF4/CPSF2/CSTF2/CSTF3/SMG7/CPSF1/RNGTT/PCF11/CPSF7/PPP2R3C	6.38817872195407
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	109/1729	368/9376	1.60620615082858	GPX3/TUBA1C/TUBB/CHCHD10/TUBA1B/HSPA5/SRSF3/HNRNPA3/SRSF7/NDUFA4/UQCRH/ACTG1/HNRNPA1/TUBB4B/NDUFV3/COX5A/CYC1/TOMM40/CYCS/HNRNPA2B1/ALYREF/NDUFC1/NDUFA6/VDAC1/FUS/UQCRFS1/PSMA7/COX8A/COX8C/NDUFS7/NUP37/NDUFA3/SLC1A2/COX7B/TUBB6/NDUFV2/NDUFB11/COX5B/NDUFS6/MAPK13/EIF2S1/SIGMAR1/NDUFS2/PSMA4/NDUFA12/NDUFA9/PSMC5/SEH1L/XBP1/PSMC4/NDC1/KIF5B/COX6A1/NDUFC2/SDHA/PSMD11/TARDBP/UQCRC1/NUP62/PSMD14/NUP88/NDUFS8/PSMD2/NUP205/RAE1/NDUFS3/PSMC3/COX7A2L/PSMD12/NUP54/NUP210/MATR3/DNALI1/HNRNPA1L2/NUP50/DERL1/NDUFA8/PSMD3/NDUFV1/SEC13/POM121/NRG4/POM121C/NUP155/SDHB/NUP153/NUP98/NOS2/NUP160/MAP2K6/GPX7/NCBP1/NUP107/PPP3CA/DCTN2/ERN1/GRIN2D/NUP188/VAPB/NUP43/WDR41/NUP35/CCS/DCTN5/MAPK14/RANBP2/CASP3/MTOR/NDUFS1	5.64115001310351
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	24/1729	44/9376	2.95788422104212	HMGB1/POLD2/APEX1/NTHL1/SMUG1/POLE4/FEN1/RFC4/RFC3/RFC5/RFC2/LIG1/LIG3/POLD1/POLE/NEIL3/POLE2/TDP1/POLD3/MBD4/PNKP/POLG2/OGG1/PARP2	6.18961404421416
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	28/1729	56/9376	2.71139386928861	OSTC/MAN1A2/STT3B/RPN2/SRD5A3/DHRSX/GANAB/STT3A/ALG8/MAGT1/DAD1/KRTCAP2/B4GALT1/MAN2A1/ALG3/DOLPP1/ALG9/DPAGT1/RPN1/DPM1/B4GALT2/ALG6/MGAT1/ALG2/ALG12/DOLK/ALG14/B4GALT3	6.10764264742048
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	16/1729	23/9376	3.77237407901023	SSBP1/POLD2/RPA3/RFC4/RFC3/RFC5/RFC2/LIG1/MSH2/EXO1/POLD1/RPA2/MSH6/POLD3/MLH1/MSH3	6.3296233869067
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	22/1729	41/9376	2.90978854265119	SSBP1/POLD2/RPA3/XRCC2/RAD51C/RAD51/BRCA1/POLD1/RPA2/XRCC3/RAD54L/BLM/EME1/POLD3/BRCA2/RAD51D/BARD1/BRCC3/RAD54B/ATM/RAD52/BRIP1	5.82716935965929
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	18/1729	30/9376	3.25367264314633	MDH2/IDH3G/FH/MDH1/SUCLG2/CS/SDHA/IDH3A/PDHB/PC/DLD/SDHB/ACLY/DLAT/PCK2/SUCLA2/DLST/ACO2	5.87863047441782
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	32/1729	75/9376	2.31372276845961	PKM/ENO1/PHGDH/TPI1/GAPDH/PGAM1/CBS/PGK1/RPIA/SHMT1/GPT2/ASL/PRPS2/IDH3G/TKT/ASNS/SHMT2/CS/MAT2A/IDH3A/ARG2/PFKL/PYCR1/PC/GOT1/ALDH18A1/PSPH/PSAT1/PRPS1/RPE/ACO2/PFKP	5.43134169792096
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	18/1729	31/9376	3.14871546110935	HSPA5/SEC11A/SRP9/SPCS3/SRP72/SEC11C/SRPRB/SEC61G/SEC61B/OXA1L/UBL4A/SEC61A1/SPCS2/IMMP1L/SRP19/SEC63/SGTA/SRP68	5.69780645134966
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	13/1729	20/9376	3.52481203007519	SQLE/EBP/LBR/DHCR24/FDFT1/DHCR7/MSMO1/TM7SF2/HSD17B7/CYP51A1/SC5D/NSDHL/LSS	5.37448099931922
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	27/1729	63/9376	2.32405188796166	POLR2H/POLD2/POLR2I/RPA3/POLR2L/POLE4/POLR2D/RFC4/GTF2H3/RFC3/RFC5/RFC2/LIG1/POLR2E/POLD1/RPA2/POLE/ERCC2/POLE2/POLD3/CUL4A/POLR2J3/CCNH/POLR2A/GTF2H2C/CUL4B/ERCC8	5.01381225923844
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	78/1729	268/9376	1.57827404331725	TUBA1C/TUBB/CALM3/TUBA1B/HSPA5/NDUFA4/CALM1/UQCRH/TUBB4B/NDUFV3/COX5A/CYC1/CYCS/PPIF/NDUFC1/NDUFA6/VDAC1/UQCRFS1/PSMA7/COX8A/UBE2L3/TXN2/COX8C/NDUFS7/NDUFA3/COX7B/PARK7/VDAC3/TUBB6/NDUFV2/NDUFB11/COX5B/NDUFS6/SLC39A4/EIF2S1/NDUFS2/PSMA4/ADCY5/NDUFA12/NDUFA9/UBA1/PSMC5/XBP1/SLC25A6/PSMC4/HTRA2/KIF5B/COX6A1/NDUFC2/SDHA/PSMD11/UQCRC1/VDAC2/PSMD14/GNAI3/SLC39A1/NDUFS8/PSMD2/SLC39A10/NDUFS3/UBE2J2/PSMC3/COX7A2L/PSMD12/NDUFA8/PSMD3/NDUFV1/SDHB/UBE2G2/ERN1/SNCA/MFN1/SLC39A3/SLC39A6/GNAI1/CASP3/UBE2G1/NDUFS1	4.56695965034548
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	62/1729	205/9376	1.64006263313067	MMP2/NDUFA4/UQCRH/GAPDH/NDUFV3/PPP1CC/COX5A/CYC1/PPIF/COL1A1/SLC2A1/NDUFC1/NDUFA6/VDAC1/UQCRFS1/PPP1CB/PPP1CA/COX8A/COX8C/NDUFS7/CYBA/PDK3/NDUFA3/COX7B/VDAC3/NDUFV2/NDUFB11/COX5B/NDUFS6/COL3A1/MAPK13/NDUFS2/NDUFA12/NDUFA9/COL1A2/SLC25A6/COX6A1/NDUFC2/SDHA/UQCRC1/VDAC2/NDUFS8/PTEN/NDUFS3/PDHB/COX7A2L/AKT1/TGFB1/NDUFA8/ATP2A2/PRKCA/NDUFV1/G6PD/SDHB/PRKCZ/MAPK14/AKT2/GYS1/PIK3CB/MTOR/PLCB3/NDUFS1	4.40583924781198
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	49/1729	154/9376	1.72543246227457	ALAS2/NME1/AK2/DHFR/UROS/AK1/NME2/MTHFD1L/VKORC1/ADSL/HMBS/SHMT1/RDH11/MMAB/AK5/GGCX/SHMT2/COQ3/NME1-NME2/MAT2A/COQ2/MTHFD2/GGH/ALDH2/GCH1/LIAS/VKORC1L1/NME6/ALDH1B1/ALDH3A2/MTHFD1/MTHFD2L/PDXK/UGDH/UMPS/DLD/PANK3/TPK1/GUSB/AK4/CTPS1/DHODH/PSAT1/PPCDC/CAD/CPOX/FLAD1/MPI/PHOSPHO2	4.31600935231951
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	13/1729	23/9376	3.06505393919582	ACAT2/ACAT1/HMGCR/FDPS/MVD/HMGCS1/IDI1/PDSS1/NUS1/PDSS2/ZMPSTE24/MVK/ICMT	4.71473666115943
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	49/1729	157/9376	1.69246241522473	HLA-G/CCNE1/CCNB1/CALM3/HLA-C/CCNB2/CALM1/CCNA2/CDK1/PPP1CC/VDAC1/EIF4EBP1/PPP1CB/PPP1CA/MAP2K2/VDAC3/MYBL2/MAPK13/FOXM1/CDC25A/E2F5/CHEK1/SLC25A6/CHEK2/VDAC2/PPID/CDK4/PTEN/E2F1/AKT1/TGFB1/CCND3/E2F2/HUS1/E2F3/MAP2K6/PPP3CA/RBL1/MYC/RAF1/MAPK14/AKT2/ATM/CCNE2/PIK3CB/LIN54/MTOR/CCND2/LIN9	4.1604634843592
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	29/1729	78/9376	2.01616467203512	ENO1/LSM4/EXOSC8/HSPD1/PABPC4/LSM5/LSM7/LSM2/DCPS/EXOSC5/EXOSC3/PABPC1/HSPA9/EXOSC2/EXOSC9/PNPT1/LSM6/LSM3/EXOSC7/NUDT16/PFKL/DCP1A/TOB2/CNOT3/EXOSC10/EXOSC4/ZCCHC7/CNOT10/PFKP	4.2850334090167
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	39/1729	117/9376	1.80759591285907	ACTG1/RUVBL2/RUVBL1/ACTR6/HDAC1/SMARCC1/CDK2AP2/BAZ1B/SMARCA4/GATAD2A/SMARCB1/CHRAC1/BPTF/MRGBP/MTA3/UCHL5/BRD9/HDAC2/CHD4/CDK2AP1/CECR2/MBD2/ACTL6A/DPF3/CHD3/MTA1/MCRS1/SMARCA2/SS18/SMARCA5/YEATS4/PHF6/NFRKB/SMARCD1/ARID2/MTA2/ARID1A/PBRM1/INO80	4.17967574478311
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	45/1729	142/9376	1.71848907208433	UBE2S/UBE2C/CDC20/SAE1/ANAPC11/UBE2L3/CBLB/UBE2E3/UBA2/ANAPC5/UBA1/UBE2D2/UBE2N/UBE2M/UBE2K/UBE2F/HERC3/CDC27/UBE2J2/BRCA1/FBXW7/PRPF19/ANAPC7/CDC26/RCHY1/UBR5/ANAPC10/UBE2G2/CUL1/HUWE1/UBE2O/CBLC/CUL4A/ANAPC1/ITCH/FBXO4/CUL2/UBE4B/UBE4A/UBE2Z/VHL/CUL4B/CDC16/UBE2G1/ERCC8	4.10210708997494
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	20/1729	47/9376	2.30756925045839	LDHA/PKM/ACAT2/ACAT1/MDH2/GLO1/FH/MDH1/ADH5/ALDH2/PDHB/ALDH1B1/ALDH3A2/ACSS2/ALDH9A1/ACACA/PC/DLD/DLAT/PCK2	4.27300765734083
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	19/1729	44/9376	2.34165834165834	OSTC/MAN1A2/STT3B/RPN2/STT3A/MAGT1/DAD1/KRTCAP2/B4GALT1/MAN2A1/ALG3/ALG9/RPN1/B4GALT2/MGAT1/ALG2/ALG12/ALG14/B4GALT3	4.24149049510467
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	15/1729	31/9376	2.62392955092446	ACAT2/ACAT1/PCCA/MDH2/SHMT1/MDH1/SHMT2/CS/PCCB/PGP/ACSS2/DLD/GLDC/GLYCTK/ACO2	4.30621757010937
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	48/1729	157/9376	1.65792236593443	LEP/NDUFA4/UQCRH/NDUFV3/COX5A/CYC1/CYCS/NDUFC1/NDUFA6/CDC42/UQCRFS1/COX8A/COX8C/NDUFS7/NDUFA3/COX7B/NDUFV2/NDUFB11/COX5B/NDUFS6/MAPK13/PPARG/EIF2S1/NDUFS2/NDUFA12/NDUFA9/XBP1/COX6A1/NDUFC2/SDHA/UQCRC1/NDUFS8/NDUFS3/COX7A2L/AKT1/TGFB1/NDUFA8/MLX/NDUFV1/SDHB/ERN1/ITCH/MAPK14/ADIPOR2/AKT2/CASP3/PIK3CB/NDUFS1	3.95293942144869
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	43/1729	138/9376	1.68970922289	CCNE1/CCNB1/PTTG1/CALM3/CDC20/CCNB2/CALM1/AURKA/CDK1/MAD2L1/PPP1CC/PLK1/SMC1A/ANAPC11/PPP1CB/PPP1CA/YWHAQ/YWHAB/FBXO5/BUB1/MAPK13/CDC25C/ADCY5/ANAPC5/PPP2R1A/YWHAE/IGF1/PPP2R5C/CDC27/PKMYT1/PPP2R1B/ANAPC7/CDC26/SMC3/ANAPC10/CUL1/PPP3CA/MAD2L2/ESPL1/ANAPC1/MAPK14/CCNE2/CDC16	3.881094232299
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	17/1729	39/9376	2.36377927066186	AHCY/TYMS/DHFR/CBS/MTHFD1L/SHMT1/AHCYL1/SHMT2/MAT2A/MTHFD2/GART/ATIC/MTHFD1/MTHFD2L/DLD/CHDH/GLDC	4.05798370495639
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	21/1729	54/9376	2.10886189833558	UBE2T/FANCI/RPA3/RAD51C/RAD51/FANCG/BRCA1/RPA2/FANCD2/USP1/BLM/FANCA/FANCB/EME1/BRCA2/RMI1/FANCE/MLH1/FANCM/BRIP1/REV3L	3.88559365488965
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	29/1729	85/9376	1.85012758139693	RRM2/TK1/DTYMK/NME1/IMPDH2/TYMS/GMPS/AK2/NT5C/DUT/AK1/NT5C3B/HDDC2/NME2/ADSL/ADK/RRM1/ADA/AK5/HPRT1/ITPA/NME1-NME2/NUDT16/IMPDH1/NME6/UCK1/NT5M/AK4/CTPS1	3.74369042910706
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	35/1729	110/9376	1.72543246227457	CCNB1/CCNB2/CCNA2/AURKA/HSP90AB1/CDK1/MAD2L1/HSP90AA1/PLK1/ANAPC11/BUB1/MAPK13/CDC25C/ADCY5/ANAPC5/CDC25A/IGF1/CDC25B/GNAI3/CDC27/KIF22/PKMYT1/AKT1/ANAPC7/CDC26/ANAPC10/BRAF/MAD2L2/ANAPC1/RAF1/MAPK14/AKT2/GNAI1/PIK3CB/CDC16	3.63902274652523
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	64/1729	235/9376	1.47684432029337	NDUFA4/UQCRH/ACTG1/RPS6/NDUFV3/COX5A/CYC1/NDUFC1/NDUFA6/GRB2/UQCRFS1/COX8A/COX8C/NDUFAF2/NDUFS7/NDUFA3/COX7B/NDUFV2/NDUFB11/COX5B/NDUFS6/COA1/MAPK13/PPARG/NDUFS2/COA4/ADCY5/NDUFA12/FGFR1/CPT1C/NDUFA9/RPS6KB2/COA6/KDM1A/SMARCC1/COX6A1/NDUFAF4/NDUFC2/SDHA/UQCRC1/SMARCA4/SMARCB1/NDUFS8/NDUFS3/COX7A2L/NDUFA8/COA7/ACTL6A/NDUFV1/DPF3/NDUFAF6/NDUFAF1/SDHB/SMARCA2/ACSL4/COX11/CREB1/SMARCD1/NDUFAF7/MAPK14/RPS6KB1/ARID1A/MTOR/NDUFS1	3.52006984262682
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	80/1729	308/9376	1.40851629573434	GPX3/TUBA1C/TUBB/TUBA1B/NDUFA4/UQCRH/TUBB4B/NDUFV3/COX5A/CYC1/CYCS/POLR2H/PPIF/NDUFC1/NDUFA6/VDAC1/UQCRFS1/PSMA7/COX8A/POLR2I/COX8C/NDUFS7/TFAM/NDUFA3/SLC1A2/COX7B/VDAC3/TUBB6/NDUFV2/NDUFB11/COX5B/NDUFS6/POLR2L/PPARG/NDUFS2/TAF4B/PSMA4/NDUFA12/POLR2D/NDUFA9/PSMC5/SLC25A6/PSMC4/HDAC1/KIF5B/COX6A1/NDUFC2/SDHA/PSMD11/UQCRC1/VDAC2/PSMD14/NDUFS8/PSMD2/NDUFS3/PSMC3/TBPL1/COX7A2L/PSMD12/DNALI1/HDAC2/NDUFA8/POLR2E/PSMD3/NDUFV1/IFT57/SDHB/AP2A1/REST/GPX7/CREB1/DCTN2/ERN1/DCTN5/POLR2J3/POLR2A/CASP3/MTOR/PLCB3/NDUFS1	3.46630343482157
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	24/1729	67/9376	1.94249113023661	LDHA/PKM/ENO1/TPI1/GAPDH/GPI/PGAM1/PGK1/G6PC3/ADH5/ALDH2/HK1/PGM1/PDHB/ALDH1B1/ALDH3A2/ACSS2/ALDH9A1/PFKL/DLD/DLAT/PCK2/ALDH3B2/PFKP	3.68129607431462
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	61/1729	224/9376	1.47674130380897	HLA-G/CCNE1/PTTG1/HLA-C/CALR/CDC20/RAN/RANBP1/CCNB2/CCNA2/MAD2L1/SLC2A1/CANX/VDAC1/ANAPC11/BUB3/MAP2K2/VDAC3/XPO1/FDPS/NFYB/IL1R1/ADCY5/ANAPC5/CHEK1/BUB1B/SLC25A6/CHEK2/VDAC2/TSPO/CDK4/PTEN/CDC27/E2F1/TBPL1/AKT1/TGFB1/CRTC3/CCND3/E2F2/ANAPC7/CDC26/TLN1/IL2RB/E2F3/ANAPC10/PPP3CA/CREB1/ESPL1/TCF3/ANAPC1/MYC/DLG1/AKT2/ATM/CCNE2/KAT2A/PIK3CB/CCND2/CDC16/CDKN2C	3.43388995286268
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	24/1729	71/9376	1.83305501022328	LDHA/PKM/SLC16A3/SLC2A1/PGAM1/SLC1A5/MAP2K2/FGFR1/HK1/PTEN/PDHB/AKT1/PDK1/PFKL/FGFR3/G6PD/ERBB2/SCO2/MYC/RAF1/AKT2/PIK3CB/MTOR/PFKP	3.35028888152111
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/1729	48/9376	2.03354540196645	ACAT2/ACAT1/PCCA/HSD17B10/HADH/HMGCS1/MCCC2/PCCB/ALDH2/AACS/ALDH1B1/ALDH3A2/ALDH9A1/OXCT1/DLD/IVD/ACAA1/ACSF3	3.41344963246411
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	20/1729	57/9376	1.90273253985165	ACAT2/ACAT1/HSD17B12/SCD/ELOVL6/HADH/FADS1/ELOVL5/CPT1C/ELOVL1/CBR4/FASN/ACACA/ELOVL2/FADS2/ACSL4/ACAA1/MCAT/PPT2/ACSF3	3.2504946757574
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	18/1729	50/9376	1.9522035858878	SRM/ODC1/AMD1/GAMT/CKB/P4HA2/ALDH2/SAT2/ALDH1B1/ALDH3A2/ALDH9A1/CKMT1A/ARG2/PYCR1/P4HA1/NOS2/GOT1/ALDH18A1	3.20999753567031
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	39/1729	138/9376	1.53252696959791	PPA1/NDUFA4/UQCRH/NDUFV3/COX5A/CYC1/CYCS/NDUFC1/NDUFA6/UQCRFS1/COX8A/COX8C/NDUFS7/NDUFA3/COX7B/NDUFV2/NDUFB11/COX5B/NDUFS6/NDUFS2/NDUFA12/NDUFA9/PPA2/ATP6V0B/COX6A1/NDUFC2/SDHA/UQCRC1/NDUFS8/NDUFS3/ATP6V0A4/COX7A2L/NDUFA8/NDUFV1/ATP6V1A/SDHB/COX11/ATP6V0E2/NDUFS1	2.99660680422673
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	24/1729	75/9376	1.73529207634471	BIRC5/TOP2A/MGST1/CYCS/MGST3/GSTA4/GSTO1/BAK1/TOP2B/AKT1/MSH2/BRCA1/SLC31A1/MSH6/ERBB2/MLH1/AKT2/ATM/CASP3/PIK3CB/ATP7B/GSTO2/REV3L/MSH3	3.03992791347034
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	20/1729	59/9376	1.83823313172109	RRM2/TK1/DTYMK/NME1/TYMS/NT5C/DUT/NT5C3B/HDDC2/NME2/RRM1/NME1-NME2/NME6/UCK1/UMPS/NT5M/CTPS1/DHODH/CDADC1/CAD	3.07107463069588
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	21/1729	63/9376	1.80759591285907	ACAT2/ACAT1/EZH2/HYKK/DHTKD1/HADH/PLOD1/GCDH/AADAT/ALDH2/COLGALT1/ALDH1B1/ALDH3A2/ALDH9A1/DLD/CAMKMT/SUV39H2/SMYD3/AASS/DLST/SETD2	3.05813867660216
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/1729	110/9376	1.57753825122246	LDHA/ENO1/GAPDH/RPS6/TIMP1/SLC2A1/EIF4EBP1/MAP2K2/PGK1/EGLN3/EIF4E/RPS6KB2/IGF1/MKNK1/HK1/PDHB/AKT1/PDK1/PRKCA/PFKL/CDKN1B/EGLN1/ERBB2/NOS2/CUL2/AKT2/VHL/PIK3CB/RPS6KB1/MTOR/ARNT/PFKP	2.89713369952761
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	58/1729	227/9376	1.38555810060563	NDUFA4/UQCRH/NDUFV3/MGST1/COX5A/CYC1/PPIF/NDUFC1/NDUFA6/GRB2/ACP1/VDAC1/UQCRFS1/COX8A/COX8C/MGST3/NDUFS7/CYBA/NDUFA3/COX7B/MAP2K2/VDAC3/GSTA4/NDUFV2/NDUFB11/COX5B/NDUFS6/MAPK13/NDUFS2/GSTO1/NDUFA12/NDUFA9/SLC25A6/COX6A1/NDUFC2/SDHA/UQCRC1/VDAC2/NDUFS8/PTEN/NDUFS3/CBR1/COX7A2L/AKT1/NDUFA8/NDUFV1/ABL1/SDHB/BRAF/PRKD3/RAF1/MAPK14/AKT2/SLC26A6/PIK3CB/ARNT/GSTO2/NDUFS1	2.79610538983426
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	36/1729	128/9376	1.52515905147484	RRM2/NME1/IMPDH2/GMPS/PAICS/AK2/NT5C/AK1/PDE4D/HDDC2/NME2/ADSL/ADK/NUDT5/ADCY5/PRPS2/RRM1/ADA/AK5/HPRT1/ITPA/NME1-NME2/GART/ATIC/NUDT16/PGM1/IMPDH1/NME6/PPAT/PFAS/NT5M/PDE6H/PAPSS1/AK4/PDE4C/PRPS1	2.84452345570719
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	68/1729	275/9376	1.34090751353909	TUBA1C/TUBB/TUBA1B/HSPA5/CAV1/NDUFA4/UQCRH/TUBB4B/NDUFV3/COX5A/CYC1/HSPA8/CYCS/PPIF/NDUFC1/NDUFA6/STIP1/VDAC1/UQCRFS1/PSMA7/COX8A/COX8C/NDUFS7/CYBA/NDUFA3/COX7B/VDAC3/TUBB6/NDUFV2/NDUFB11/COX5B/NDUFS6/MAPK13/EIF2S1/NDUFS2/PSMA4/NDUFA12/NDUFA9/PSMC5/SLC25A6/PSMC4/KIF5B/COX6A1/NDUFC2/SDHA/PSMD11/UQCRC1/VDAC2/PSMD14/NDUFS8/PSMD2/NDUFS3/PSMC3/COX7A2L/PSMD12/NDUFA8/PSMD3/FYN/NDUFV1/SDHB/PPP3CA/CREB1/GRIN2D/CSNK2A1/MAPK14/CASP3/PIK3CB/NDUFS1	2.72832405796988
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	13/1729	34/9376	2.0734188412207	POLR2H/POLR2I/POLR2L/POLR1D/POLR2D/POLR1E/POLR3G/POLR2E/POLR3H/POLR1A/POLR2J3/POLR2A/POLR1B	2.98144176407266
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	11/1729	27/9376	2.20928389349442	HSD17B12/SCD/ELOVL6/ACOT4/FADS1/ELOVL5/ELOVL1/ELOVL2/FADS2/ACAA1/ACOT7	2.9920246037263
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	12/1729	31/9376	2.09914364073957	GPI/PGLS/RPIA/PRPS2/TKT/PGM1/PFKL/G6PD/PRPS1/RPE/GLYCTK/PFKP	2.91462868886908
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	91/1729	388/9376	1.27183939229517	TUBA1C/TUBB/CALM3/TUBA1B/NDUFA4/CALM1/UQCRH/GAPDH/TUBB4B/NDUFV3/COX5A/CYC1/CYCS/PPIF/NDUFC1/NDUFA6/VDAC1/UQCRFS1/PSMA7/COX8A/COX8C/NDUFS7/NDUFA3/COX7B/MAP2K2/BACE2/VDAC3/TUBB6/NDUFV2/NDUFB11/COX5B/NDUFS6/SLC39A4/HSD17B10/DKK1/EIF2S1/NDUFS2/FZD3/PSMA4/NDUFA12/NDUFA9/PSMC5/XBP1/SLC25A6/PSMC4/KIF5B/COX6A1/NDUFC2/SDHA/PSMD11/UQCRC1/VDAC2/PPID/PSMD14/SLC39A1/NDUFS8/PSMD2/SLC39A10/NDUFS3/PSMC3/COX7A2L/AKT1/PSMD12/LRP6/NDUFA8/PSMD3/ATP2A2/NDUFV1/CSNK1E/SDHB/NOS2/BRAF/DVL3/PPP3CA/ERN1/SNCA/GRIN2D/FRAT2/IDE/CSNK2A1/SLC39A3/SLC39A6/RAF1/AXIN2/AKT2/CASP3/PIK3CB/MTOR/PLCB3/NDUFS1/APH1B	2.60036499615948
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	22/1729	73/9376	1.63426479792738	RAN/PPIA/XPO1/CHMP4A/PIN1/NELFCD/CPSF6/SMARCB1/MAP1B/NELFE/TNPO3/NUP153/CCNT1/NELFB/TRIM5/RANBP2/FURIN/CHMP6/BICD2/KAT2A/NELFA/CPSF7	2.58677180000588
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	12/1729	33/9376	1.97192281402808	DHTKD1/GPT2/IDH3G/CS/AADAT/IDH3A/PDHB/DLD/GOT1/DLAT/DLST/ACO2	2.65939692181065
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	33/1729	122/9376	1.46681963420531	LEP/CCNA2/EEF2/SCD/EIF4EBP1/HMGCR/PPARG/CPT1C/CAB39L/RPS6KB2/G6PC3/PPP2R1A/IGF1/PPP2R5C/ELAVL1/FASN/AKT1/EEF2K/RAB10/PPP2R1B/ACACA/PFKL/PFKFB4/CREB1/PCK2/ADIPOR2/AKT2/GYS1/PIK3CB/RPS6KB1/MTOR/PFKP/PPP2R3C	2.46775403941747
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	14/1729	41/9376	1.85168361805076	PHGDH/ALAS2/PGAM1/CBS/SHMT1/GAMT/SHMT2/GCAT/DLD/CHDH/PSPH/GLDC/PSAT1/GLYCTK	2.59866711543864
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	108/1729	480/9376	1.22012724117987	GPX3/TUBA1C/TUBB/CALM3/TUBA1B/HSPA5/NDUFA4/CALM1/UQCRH/TUBB4B/NDUFV3/COX5A/CYC1/TOMM40/CYCS/PPIF/NDUFC1/NDUFA6/VDAC1/FUS/UQCRFS1/PSMA7/COX8A/UBE2L3/COX8C/NDUFS7/NDUFA3/COX7B/MAP2K2/PARK7/VDAC3/TUBB6/NDUFV2/NDUFB11/COX5B/NDUFS6/HSD17B10/MAPK13/DKK1/EIF2S1/SIGMAR1/NDUFS2/FZD3/PSMA4/NDUFA12/NDUFA9/UBA1/PSMC5/XBP1/SLC25A6/PSMC4/HTRA2/KIF5B/COX6A1/NDUFC2/SDHA/PSMD11/TARDBP/UQCRC1/VDAC2/PPID/BAK1/PSMD14/NDUFS8/PSMD2/NDUFS3/UBE2J2/PSMC3/COX7A2L/PSMD12/DNALI1/DERL1/LRP6/NDUFA8/PSMD3/ATP2A2/PRKCA/NDUFV1/CSNK1E/IFT57/SDHB/NOS2/UBE2G2/MAP2K6/BRAF/DVL3/GPX7/PPP3CA/DCTN2/ERN1/SNCA/GRIN2D/MFN1/VAPB/FRAT2/WDR41/ATXN3/CSNK2A1/CCS/DCTN5/RAF1/MAPK14/AXIN2/CASP3/MTOR/PLCB3/UBE2G1/NDUFS1	2.3541526048449
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1729	87/9376	1.55827233867161	BIRC5/CYCS/GRB2/MAP2K2/RHOA/RAC3/RPS6KB2/BAK1/RALB/AKT1/MSH2/TGFB1/RALA/MSH6/BRAF/MYC/RAF1/MLH1/AXIN2/AKT2/CASP3/PIK3CB/RPS6KB1/MTOR/MSH3	2.48747568677855
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/1729	75/9376	1.59068440331598	CCNE1/CCNB1/RRM2/CCNB2/CDK1/CYCS/SIVA1/GTSE1/EI24/CHEK1/CHEK2/IGF1/CDK4/PTEN/CCNG1/CCND3/RCHY1/TP53I3/ATM/CASP3/CCNE2/CCND2	2.44207446735768
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/1729	54/9376	1.70717391770023	LDHA/SRM/PHGDH/AHCY/MPST/CBS/MDH2/TST/AMD1/MDH1/ADI1/DNMT3B/AHCYL1/MAT2A/GOT1/PSAT1/MRI1	2.47802768915043
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/1729	93/9376	1.51604818497858	CCNE1/CKS1B/CYCS/LAMA4/CKS2/LAMA1/COL4A1/BAK1/CDK4/PTEN/COL4A2/E2F1/AKT1/E2F2/TRAF4/CDKN1B/LAMB1/E2F3/NOS2/ITGAV/TRAF5/MYC/AKT2/CASP3/CCNE2/PIK3CB	2.3780727898581
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	36/1729	138/9376	1.41464027962884	CALM3/CALM1/PYGL/RPS6/PPP1CC/GRB2/EIF4EBP1/PPP1CB/PPP1CA/MAP2K2/CBLB/EIF4E/RPS6KB2/SH2B2/G6PC3/MKNK1/HK1/FASN/AKT1/PRKAR2A/ACACA/PRKCZ/BRAF/PRKAR1A/PCK2/CRK/CRKL/RAF1/INPP5A/PPP1R3B/AKT2/GYS1/PIK3CB/PHKG2/RPS6KB1/MTOR	2.33324123317252
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	22/1729	77/9376	1.54936792530777	RALBP1/CDC42/RAC3/RPS6KB2/BAK1/CDK4/RALB/E2F1/AKT1/RAD51/TGFB1/E2F2/RALA/ERBB2/E2F3/BRAF/BRCA2/RAF1/AKT2/PIK3CB/RPS6KB1/MTOR	2.30159088069964
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	22/1729	77/9376	1.54936792530777	GRB2/MAP2K2/HDAC1/BAK1/CDK4/E2F1/AKT1/HDAC2/TGFB1/E2F2/ABL1/CDKN1B/E2F3/BRAF/CTBP2/CRK/CTBP1/MYC/CRKL/RAF1/AKT2/PIK3CB	2.30159088069964
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	23/1729	82/9376	1.52102582911312	RRM2/TK1/NME1/MGST1/IMPDH2/GMPS/DUT/MGST3/GSTA4/NME2/GSTO1/RRM1/HPRT1/ITPA/NME1-NME2/IMPDH1/NME6/UCK1/UMPS/GUSB/TPMT/CDADC1/GSTO2	2.25321397007555
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1729	28/9376	1.93670990663472	HSD17B12/ELOVL6/HADH/THEM4/ACOT4/ELOVL5/ELOVL1/ELOVL2/ACOT7/PPT2	2.36027369855269
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/1729	10/9376	2.71139386928861	MPST/TST/SELENBP1/PAPSS1/SUOX	2.57460426827233
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/1729	70/9376	1.54936792530777	SLC2A1/GRB2/CDC42/MAP2K2/EGLN3/FH/AKT1/TGFB1/EGLN1/BRAF/CRK/PRCC/CRKL/RAF1/CUL2/PAK4/AKT2/VHL/PIK3CB/ARNT	2.19365529784138
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1729	21/9376	2.06582390041037	DSEL/CHSY1/CHST12/B4GALT7/XYLT1/B3GALT6/CSGALNACT1/XYLT2	2.32493489554349
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1729	14/9376	2.32405188796166	B4GALT1/B3GNT7/ST3GAL1/B4GALT2/B4GALT3/B4GALT4	2.35734037233998
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	48/1729	203/9376	1.28223552439264	CAV1/ACTG1/PPP1CC/LAMA4/COL1A1/PGF/GRB2/CDC42/PPP1CB/PPP1CA/LAMA1/COL6A2/RHOA/COL6A3/COL6A1/RAC3/COL1A2/COL4A1/IGF1/FLT4/COL9A3/ITGA5/PTEN/PARVA/COL4A2/AKT1/VCL/MYL5/CCND3/FYN/PRKCA/PPP1R12A/ITGB5/LAMB1/ERBB2/TLN1/ITGAV/BRAF/CRK/ITGB8/CRKL/RAF1/PAK4/AKT2/PIK3CB/PXN/CCND2/DOCK1	1.9330433277854
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	41/1729	170/9376	1.30784880753921	ACTG1/MGST1/GRB2/MGST3/MAP2K2/GSTA4/FZD3/GSTO1/RPS6KB2/SMARCC1/BAK1/CDK4/SMARCA4/SMARCB1/PTEN/E2F1/AKT1/TGFB1/LRP6/E2F2/ACTL6A/PRKCA/DPF3/SMARCA2/E2F3/BRAF/DVL3/TXNRD1/FRAT2/SMARCD1/MYC/RAF1/AXIN2/AKT2/ARID2/PIK3CB/RPS6KB1/ARID1A/MTOR/PBRM1/GSTO2	1.92603440551352
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1729	30/9376	1.80759591285907	GPAA1/PIGF/PIGW/PIGH/PIGX/PIGK/PIGT/PIGU/PIGS/PGAP1	2.10658720057967
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1729	30/9376	1.80759591285907	TYMS/ABCG2/DHFR/SLC19A1/SHMT1/SHMT2/GART/ATIC/GGH/ABCC5	2.10658720057967
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/1729	15/9376	2.16911509543089	AK2/ACP1/AK1/AK5/TPK1/AK4	2.15466305331666
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	7/1729	19/9376	1.99786916684424	DHTKD1/LIAS/PDHB/DLD/DLAT/GLDC/DLST	2.07023515458353
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	13/1729	44/9376	1.60218728639781	TAF4B/TAF9/GTF2H3/TBPL1/GTF2F2/TAF15/TAF12/ERCC2/GTF2F1/CCNH/GTF2H2C/TAF9B/TAF8	1.90374223617329
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/1729	12/9376	2.25949489107384	VKORC1/GGCX/COQ3/COQ2/VKORC1L1	2.07584021126704
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1729	24/9376	1.80759591285907	HS3ST3B1/HS6ST2/EXTL2/B4GALT7/XYLT1/HS2ST1/B3GALT6/XYLT2	1.88358435214319
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/1729	59/9376	1.47058650537687	GPX3/SRM/RRM2/MGST1/ODC1/MGST3/GSTA4/GSTO1/RRM1/GGCT/ANPEP/TXNDC12/G6PD/GPX7/LANCL1/GSTO2	1.72411018309834
NA	NA	hsa04518	Integrin signaling	36/1729	154/9376	1.26766466616091	ACTG1/LAMA4/COL1A1/PGF/CDC42/LAMA1/ITGAE/COL6A2/COL6A3/COL6A1/LIMS1/RAC3/COL1A2/COL4A1/IGF1/FRAS1/FLT4/COL9A3/ITGA5/PARVA/COL4A2/AKT1/VCL/TGFB1/CCND3/ITGB5/LAMB1/ERBB2/TLN1/ITGAV/ITGB8/AKT2/PIK3CB/MTOR/PXN/CCND2	1.59248898072982
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/1729	42/9376	1.54936792530777	ACAT2/ACAT1/DHTKD1/HADH/GCDH/AADAT/ALDH2/ALDH1B1/ALDH3A2/ALDH9A1/DLD/DLST	1.69664755788808
Cellular Processes	Cell motility	hsa04814	Motor proteins	44/1729	194/9376	1.2299106211206	TUBA1C/TUBB/DYNLL1/TUBA1B/ACTG1/TPM2/MYL4/TUBB4B/MYO1B/TNNI2/MYO10/CENPE/KIF2C/TPM1/KIF11/TUBB6/TPM4/KIF23/MYL6B/KIFC1/KIF4A/KIF20B/KIF20A/TPM3/KIF15/MYO7A/KIF5B/KIF14/DYNC1LI1/MYO19/KIF18A/TUBG1/KIF22/DNALI1/KIF18B/MYL5/KIF2A/ACTA2/DCTN2/KIF9/DYNLT3/MYO1E/DCTN5/TUBD1	1.53861104321003
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	48/1729	214/9376	1.21632622173694	HLA-G/CCNB1/CALM3/HLA-C/CALR/CCNB2/CALM1/CDK1/CYCS/PDIA3/MAP2K2/MAPK13/GNB2/CDC25C/CHEK1/RAC3/RPS6KB2/BAK1/GNB1/GNAI3/GNB5/AKT1/GNG12/PRKCA/AP1S1/MAP2K6/IRAK1/GNG11/CUL1/PPP3CA/CFL2/CUL4A/CRK/TRAF5/CRKL/RAF1/MAPK14/TRIM5/PAK4/AKT2/ATM/GNAI1/CASP3/PIK3CB/CUL4B/RPS6KB1/MTOR/PXN	1.52215366548803
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1729	43/9376	1.51333611309131	ACAT2/ACAT1/HADH/CPT1C/GCDH/ADH5/ALDH2/ALDH1B1/ALDH3A2/ALDH9A1/ACSL4/ACAA1	1.60421658704497
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	24/1729	99/9376	1.31461520935205	MMP2/GRB2/MAP2K2/MAPK13/ADCY5/RPS6KB2/IGF1/CDK4/E2F1/AKT1/E2F2/DLL1/CDKN1B/CARM1/ERBB2/E2F3/BRAF/RAF1/MAPK14/AKT2/PIK3CB/RPS6KB1/MTOR/CDKN2C	1.49634288351546
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	26/1729	109/9376	1.29350900186245	PYGL/PPP1CC/SLC2A1/PPP1CB/PPP1CA/SLC27A2/RPS6KB2/G6PC3/SLC27A5/PTEN/AKT1/MLX/PRKCZ/CREB1/PCK2/SLC27A6/PPP1R3B/AKT2/TRIB3/GYS1/PIK3CB/SLC27A4/RPS6KB1/OGT/NR1H2/MTOR	1.46555689393614
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1729	18/9376	1.80759591285907	CBR4/FASN/ACACA/ACSL4/MCAT/ACSF3	1.63070887280044
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	21/1729	86/9376	1.3241690989549	GRB2/EIF4EBP1/MAP2K2/CBLB/RPS6KB2/AKT1/PRKCA/ABL1/CDKN1B/NRG4/ERBB2/BRAF/CRK/MYC/CRKL/RAF1/PAK4/AKT2/PIK3CB/RPS6KB1/MTOR	1.43598721154728
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1729	110/9376	1.28174982911825	ID1/BMP4/ID3/ID2/RHOA/TFDP1/LRRC32/DCN/E2F5/ID4/RPS6KB2/GREM2/HDAC1/PPP2R1A/TGIF2/HDAC2/TGFB1/PPP2R1B/CUL1/ZFYVE16/SMAD5/RBL1/ACVR2B/MYC/ACVR1/RPS6KB1	1.41335560553237
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	29/1729	125/9376	1.25808675534991	MAP2K2/RHOA/MAPK13/CERS4/ORMDL2/RAC3/S1PR1/PPP2R1A/S1PR3/PPP2R5C/GNAI3/PTEN/AKT1/PPP2R1B/FYN/PRKCA/CERS5/SMPD2/DEGS2/PRKCZ/SGPP1/RAF1/MAPK14/AKT2/GNAI1/SPTLC1/PIK3CB/PLCB3/PPP2R3C	1.38122354680606
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	30/1729	130/9376	1.25141255505628	MMP2/COL1A1/GRB2/MAP2K2/COL3A1/MAPK13/GNB2/ADCY5/COL1A2/COL4A1/RLN2/GNB1/GNAI3/COL4A2/GNB5/AKT1/TGFB1/GNG12/PRKCA/PRKCZ/NOS2/ACTA2/GNG11/CREB1/RAF1/MAPK14/AKT2/GNAI1/PIK3CB/PLCB3	1.37252190084981
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/1729	27/9376	1.6067519225414	ACAT2/ACAT1/HADH/HMGCS1/AACS/OXCT1/L2HGDH/ACSM3	1.50123282908875
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	76/1729	362/9376	1.1384858235687	CCNE1/HSP90AB1/RPS6/HSP90B1/HSP90AA1/LAMA4/COL1A1/EIF4B/PGF/GRB2/EIF4EBP1/YWHAQ/LAMA1/YWHAB/MAP2K2/COL6A2/COL6A3/COL6A1/THEM4/GNB2/FGFR1/EIF4E/FGF7/RPS6KB2/COL1A2/SGK2/G6PC3/COL4A1/PPP2R1A/YWHAE/IGF1/FLT4/COL9A3/CDK4/ITGA5/MAGI1/GNB1/PPP2R5C/PTEN/COL4A2/GNB5/DDIT4/AKT1/PKN3/BRCA1/CCND3/PPP2R1B/GNG12/PRKCA/FGFR3/CDKN1B/ITGB5/LAMB1/ERBB2/IL2RB/ITGAV/GNG11/NR4A1/PRLR/CREB1/EFNA3/PCK2/EPOR/ITGB8/PHLPP1/MYC/RAF1/AKT2/GHR/CCNE2/GYS1/PIK3CB/RPS6KB1/MTOR/CCND2/PPP2R3C	1.27772801249071
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1729	83/9376	1.30669584062102	AURKB/EZH2/TFDP1/SUZ12/WDR5/CBX3/PCGF6/UBE2D2/HDAC1/RNF2/HDAC2/MTF2/RYBP/DCAF7/HCFC1/ASXL1/L3MBTL2/PCGF3/FBRSL1/OGT	1.33446305130775
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	11/1729	41/9376	1.45489427132559	MMP2/MAP2K2/CDK4/E2F1/E2F2/FGFR3/ERBB2/E2F3/BRAF/MYC/RAF1	1.3879787738559
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/1729	32/9376	1.52515905147484	AKR1B1/G6PC3/HK1/PGM1/B4GALT1/PFKL/B4GALT2/PFKP/GLA	1.41493672604965
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1729	46/9376	1.41464027962884	PSMA7/PSMA4/PSMC5/PSMC4/PSMD11/PSMD14/PSMD2/PSMC3/PSMF1/PSMD12/PSMD3/PSME3	1.3404393620542
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/1729	37/9376	1.46561830772357	ADSL/GPT2/ASL/ASNS/ASRGL1/RIMKLA/PPAT/RIMKLB/GOT1/CAD	1.34933042223512
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1729	37/9376	1.46561830772357	GPI/GNPNAT1/NAGK/PGM3/HK1/PGM1/UGDH/NANS/GNE/MPI	1.34933042223512
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/1729	51/9376	1.38227922748047	ACTG1/KDELR2/PDIA4/KDELR1/SEC61G/SEC61B/ATP6V0B/SEC61A1/ATP6V0A4/KDELR3/PRKCA/ATP6V1A/ATP6V0E2	1.30160424779791
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	40/1729	183/9376	1.18530879531742	RAN/FBL/RRP7A/NOP56/GNL3/DKC1/IMP4/NOP58/XPO1/POP5/RBM28/WDR43/NOP10/GAR1/POP7/TCOF1/MPHOSPH10/MDN1/RPP30/GTPBP4/EMG1/WDR75/RPP25L/RPP40/NMD3/POP1/WDR3/GNL2/UTP6/NAT10/HEATR1/UTP14A/CSNK2A1/UTP15/PWP2/RIOK1/BMS1/NVL/NOL6/RIOK2	1.20373402702458
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1729	80/9376	1.28791208791209	RPS6/GRB2/EIF4EBP1/MAP2K2/EIF4E/RPS6KB2/IGF1/PTEN/AKT1/PRKCA/FGFR3/ERBB2/BRAF/RAF1/NF1/AKT2/PIK3CB/RPS6KB1/MTOR	1.22968655525168
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	32/1729	144/9376	1.20506394190605	CYCS/PPIF/NOP56/VDAC1/PSMA7/VDAC3/PSMA4/PSMC5/XBP1/SLC25A6/PSMC4/PSMD11/VDAC2/PSMD14/AFG3L2/PSMD2/PSMC3/TBPL1/AKT1/PSMD12/PSMD3/ATP2A2/PRKCA/ATXN10/OPA1/ERN1/GRIN2D/ATXN3/AKT2/PIK3CB/MTOR/PLCB3	1.17912606407089
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/1729	76/9376	1.28434446439987	CALM3/CALM1/GRB2/MAP2K2/IGF1/BAK1/CDK4/PTEN/E2F1/AKT1/E2F2/PRKCA/E2F3/BRAF/RAF1/AKT2/PIK3CB/MTOR	1.18344393817843
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/1729	106/9376	1.22780099741371	CCNE1/ETV5/HSP90AB1/HSP90B1/HSP90AA1/GRB2/MAP2K2/SLC19A1/FGFR1/IGF1/PTEN/E2F1/AKT1/E2F2/CDKN1B/ERBB2/E2F3/BRAF/CREB1/RAF1/AKT2/CCNE2/PIK3CB/MTOR	1.12151807314105
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/1729	87/9376	1.24661787093729	UQCRH/TPM2/MYL4/COX5A/CYC1/FXYD2/UQCRFS1/TPM1/COX8A/COX8C/ATP1A1/COX7B/TPM4/COX5B/TPM3/COX6A1/ATP1B3/UQCRC1/COX7A2L/ATP2A2	1.09884713138626
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	34/1729	157/9376	1.17436167587022	CALR/SLC2A1/UQCRFS1/BSG/ODC1/SLC16A1/MAP2K2/MAPK13/PPARG/XKR8/ATP11B/CPT1C/S1PR1/PPARD/TGFB1/ATP2A2/ARG2/TYRO3/ITGB5/MFGE8/ITGAV/CREB1/ELMO1/CRK/EPOR/CRKL/MAPK14/CASP3/VPS33A/VPS16/NR1H2/ATP11A/ARNT/DOCK1	1.04760254070152
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	27/1729	122/9376	1.20012515525889	ACTG1/SLC2A1/BMP4/FXYD2/DIO2/ATP1A1/MAP2K2/MED30/HDAC1/ATP1B3/MED12L/AKT1/HDAC2/ATP2A2/PRKCA/PFKL/HDAC3/ITGAV/MYC/RAF1/AKT2/MED27/KAT2A/PIK3CB/MTOR/PLCB3/PFKP	1.05792392627165
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/1729	78/9376	1.25141255505628	CAV1/ACTG1/CDC42/RHOA/ARPC1A/ACTR2/ARPC4/ITGA5/VCL/DNM2/ARHGAP10/ELMO1/MAD2L2/CRK/CRKL/PIK3CB/PXN/DOCK1	1.06017383551116
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1729	49/9376	1.32802965026381	GXYLT1/COLGALT1/B4GALT1/GALNT2/GALNT1/B4GALT2/POFUT1/XXYLT1/POGLUT1/OGT/B4GALT3/RFNG	1.09465620276608
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/1729	83/9376	1.24136104858996	PXMP4/SLC27A2/CRAT/MPV17L2/ABCD3/MPV17/FAR1/PECR/NOS2/ACSL4/PEX19/DHRS4/MVK/PEX13/ACAA1/AGPS/ABCD4/PEX10/PEX1	1.0501850977699
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1729	35/9376	1.394431132777	AKR1B1/TPI1/ENOSF1/HK1/PFKL/PFKFB4/SORD/MPI/PFKP	1.111593792124
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/1729	133/9376	1.18241236405067	CCNB1/CCNB2/GRB2/PLK1/BNIP3/MAP2K2/PRMT1/MAPK13/ATG12/S1PR1/SGK2/G6PC3/IGF1/PTEN/AKT1/TGFB1/PLK4/CDKN1B/CSNK1E/BRAF/PCK2/NLK/RAF1/MAPK14/AKT2/ATM/PIK3CB/CCND2/HOMER1	1.00742147760829
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	43/1729	204/9376	1.143038591955	CAV1/MMP2/ACTG1/RPS6/PPP1CC/COL1A1/EIF4B/GRB2/CDC42/PPP1CB/PPP1CA/MAP2K2/CD63/RHOA/MAPK13/FZD3/DDX5/DCN/FGFR1/IQGAP1/RPS6KB2/COL1A2/LUM/IGF1/ITGA5/AKT1/TGFB1/PRKCA/PPP1R12A/ITGB5/ANK3/ERBB2/ITGAV/BRAF/MYC/RAF1/MAPK14/AKT2/CASP3/PIK3CB/RPS6KB1/MTOR/PXN	0.982141080304942
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	68/1729	333/9376	1.10735605472448	HLA-G/CCNE1/PKM/HLA-C/CCNA2/LAMA4/COL1A1/GRB2/CDC42/EIF4EBP1/LAMA1/MAP2K2/ISG15/COL6A2/COL6A3/COL6A1/FZD3/RPS6KB2/COL1A2/ATP6V0B/HDAC1/COL4A1/PPP2R1A/COL9A3/BAK1/CDK4/ITGA5/MAGI1/PPP2R5C/PTEN/COL4A2/ATP6V0A4/E2F1/TUBG1/TBPL1/AKT1/HES6/HDAC2/HEY1/CCND3/CHD4/PPP2R1B/ATP6V1A/CDKN1B/ITGB5/DLG3/LAMB1/PRKCZ/ITGAV/DVL3/CREB1/ATP6V0E2/RBL1/ITGB8/RAF1/AXIN2/DLG1/AKT2/ATM/CASP3/CCNE2/PIK3CB/RPS6KB1/MTOR/PXN/CCND2/PPP2R3C/RFNG	0.948483945290373
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1729	144/9376	1.16740569372148	ID1/BMP4/GRB2/MAP2K2/ID3/ID2/MAPK13/FZD3/FGFR1/ID4/PCGF6/IGF1/AKT1/TBX3/FGFR3/RIF1/LIFR/DVL3/REST/MEIS1/SMAD5/PCGF3/TCF3/ACVR2B/MYC/RAF1/MAPK14/AXIN2/AKT2/ACVR1/PIK3CB	0.962589594767991
NA	NA	hsa04981	Folate transport and metabolism	8/1729	31/9376	1.39942909382638	TYMS/ABCG2/DHFR/SLC19A1/SHMT1/SHMT2/MTHFD1/ABCC5	1.05917684721535
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1729	13/9376	1.66855007340837	XRCC5/XRCC6/PRKDC/FEN1	1.14692678443356
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	47/1729	227/9376	1.12277984014594	HLA-G/CALM3/HLA-C/CALR/CALM1/CYCS/GRB2/EIF4EBP1/PDIA3/MAP2K2/RHOA/MAPK13/IL1R1/GNB2/ADCY5/RAC3/RPS6KB2/BAK1/CDK4/GNB1/GNAI3/E2F1/GNB5/AKT1/E2F2/GNG12/PRKCA/E2F3/ITGAV/MAP2K6/GNG11/PPP3CA/CREB1/CRK/TRAF5/MYC/CRKL/RAF1/MAPK14/AKT2/GNAI1/CASP3/PIK3CB/RPS6KB1/MTOR/PXN/PLCB3	0.89041151581512
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1729	32/9376	1.3556969346443	LDHA/PCCA/SUCLG2/PCCB/ACSS2/ACACA/DLD/SUCLA2	0.958354720837594
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1729	18/9376	1.50632992738256	CD320/MMAB/HCFC1/ABCD4/ZNF143	1.02238841480024
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1729	142/9376	1.14565938138955	CALM3/CAV1/MMP2/CALM1/ACTG1/HSP90AB1/MGST1/HSP90B1/HSP90AA1/BMP4/TXN2/MGST3/CYBA/GSTA4/RHOA/MAPK13/IL1R1/GSTO1/SUMO2/RAC3/AKT1/PRKCZ/ITGAV/MAP2K6/ACVR2B/MAPK14/AKT2/ACVR1/PIK3CB/GSTO2	0.831620694502805
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1729	42/9376	1.29113993775648	CP/PCBP2/VDAC3/SLC7A11/SLC3A2/VDAC2/NCOA4/SAT2/ACSL4/ATG5	0.89914580309996
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/1729	23/9376	1.41464027962884	GPT2/ASL/ARG2/NOS2/GOT1/CAD	0.946667634415774
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/1729	23/9376	1.41464027962884	B3GALNT2/FUT4/B4GALT1/B4GALT2/CHST10/B4GALT3	0.946667634415774
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/1729	23/9376	1.41464027962884	FXYD2/CA2/ATP1A1/MDH1/ATP1B3/PCK2	0.946667634415774
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1729	52/9376	1.25141255505628	VDAC1/VDAC3/LDLR/PLTP/VDAC2/TSPO/LRP2/SORT1/LIPG/STARD3NL/VAPB/LDLRAP1	0.864420565864597
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1729	62/9376	1.22450045709808	HSPA8/CRYAB/CLPB/ADCY5/RPS6KB2/HDAC1/IGF1/AKT1/HDAC2/ATG5/AKT2/PIK3CB/RPS6KB1/MTOR	0.843300867892331
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	31/1729	148/9376	1.13585418848577	GRB2/MAP2K2/FZD3/FGFR1/FGF7/RPS6KB2/IGF1/FLT4/BAK1/CDK4/PTEN/E2F1/AKT1/HEY1/BRCA1/LRP6/E2F2/DLL1/ERBB2/E2F3/BRAF/DVL3/BRCA2/FRAT2/MYC/RAF1/AXIN2/AKT2/PIK3CB/RPS6KB1/MTOR	0.792113996210583
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1729	28/9376	1.3556969346443	ST3GAL4/FUT4/B4GALT1/B4GALT2/B3GNT5/B4GALT3/B4GALT4	0.896266937661578
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1729	28/9376	1.3556969346443	AKR1B1/DHFR/PCBD2/GGH/GCH1/CBR1/QDPR	0.896266937661578
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1729	38/9376	1.28434446439987	GPI/GNPNAT1/NAGK/PGM3/HK1/PGM1/UGDH/GNE/MPI	0.835116820488586
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	15/1729	68/9376	1.19620317762733	CCNA2/GRB2/EIF4EBP1/MAP2K2/DUSP6/RPS6KB2/AKT1/PPARD/BRAF/MYC/RAF1/AKT2/PIK3CB/RPS6KB1/MTOR	0.772093498682142
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/1729	248/9376	1.09330397955186	TUBA1C/TUBB/DYNLL1/TUBA1B/ACTG1/HSP90AB1/GAPDH/TUBB4B/HSP90B1/CYCS/HSP90AA1/PYCARD/CDC42/TXN2/MAP2K2/CSE1L/TUBB6/RHOA/MAPK13/ARPC1A/FBXO22/ACTR2/ARPC4/KIF5B/DYNC1LI1/BRK1/BAK1/AKT1/MYL5/DNM2/RALA/PIK3C2G/MAP2K6/IRAK1/KPNA4/DCTN2/GSDMD/DYNLT3/ELMO1/NCKAP1/PIK3C2A/DCTN5/MYC/RAF1/MAPK14/AKT2/CASP3/VPS33A/VPS16/PIK3CB	0.708069327631267
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1729	59/9376	1.19485153561871	GRB2/MAP2K2/BAK1/PTEN/AKT1/ERBB2/BRAF/MYC/RAF1/MLH1/AXIN2/AKT2/PIK3CB	0.713886847400179
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	16/1729	75/9376	1.15686138422981	GPX3/CGA/HSPA5/HSP90B1/PDIA4/CANX/FXYD2/ATP1A1/ADCY5/ATP1B3/LRP2/PRKCA/GPX7/CREB1/TTF2/PLCB3	0.648514129019707
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1729	70/9376	1.16202594398083	HLA-G/HLA-C/CAV1/ACTG1/CYCS/LAMA1/RAC3/CD55/EIF4G1/SGCB/FYN/DAG1/ABL1/CASP3/EIF4G3	0.646978198084966
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1729	20/9376	1.3556969346443	UGDH/NANS/CYB5RL/GNE/CYB5R3	0.757159897049829
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1729	65/9376	1.16798505138586	AKR1B1/AGPAT5/AGPAT4/ALDH2/ALDH1B1/ALDH3A2/GPAM/ALDH9A1/LCLAT1/LIPG/DGKD/GLYCTK/DGKZ/GLA	0.646199683976127
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	41/1729	205/9376	1.08455754771544	HLA-G/CCNE1/PKM/HLA-C/CDC20/RANBP1/CCNA2/CDK1/GRB2/CDC42/YWHAQ/YWHAB/VDAC3/RHOA/HNRNPK/CHEK1/HDAC1/YWHAE/BAK1/CDK4/GTF2H3/TBPL1/DDX3X/HDAC2/CCND3/CHD4/REL/CDKN1B/HDAC3/CREB1/RBL1/TRAF5/HDAC5/DLG1/GTF2H2C/CASP3/CCNE2/KAT2A/PIK3CB/PXN/CCND2	0.582047667118501
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1729	107/9376	1.11496570325887	LDHA/CALM3/PKM/CALM1/PYGL/SLC2A1/PGAM1/PRMT1/CPT1C/G6PC3/PDHB/AKT1/ACACA/PFKL/PPP3CA/CREB1/PCK2/AKT2/GYS1/PHKG2/PLCB3/PFKP	0.568697524494441
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	36/1729	180/9376	1.08455754771544	HLA-G/HLA-C/CALR/SRSF3/SRSF7/PPP1CC/SRSF2/CYCS/ALYREF/EIF4EBP1/PPP1CB/PPP1CA/PDIA3/SRSF9/SRSF5/SRSF1/EIF2S1/SRSF6/SRPK1/SRSF4/BAK1/ITGA5/AKT1/EIF2B2/IRAK1/EIF2B5/HCFC1/TRAF5/EIF2B3/AKT2/CASP3/POU2F1/PIK3CB/MTOR/OAS3/ZC3HAV1	0.544661578471675
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	27/1729	133/9376	1.10086668377131	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/MAPK13/GNB2/ADCY5/COMT/KIF5B/PPP2R1A/GNB1/PPP2R5C/GNAI3/GNB5/AKT1/PPP2R1B/GNG12/PRKCA/GNG11/PPP3CA/CREB1/MAPK14/AKT2/GNAI1/PLCB3/PPP2R3C	0.557063465161379
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1729	149/9376	1.09183645743165	NDUFA4/NDUFV3/NDUFC1/NDUFA6/NDUFS7/NDUFA3/NDUFV2/NDUFB11/NDUFS6/MAPK13/GNB2/NDUFS2/ADCY5/NDUFA12/NDUFA9/NDUFC2/GNB1/GNAI3/NDUFS8/NDUFS3/GNB5/NDUFA8/GNG12/PRKCA/NDUFV1/GNG11/MAPK14/GNAI1/PLCB3/NDUFS1	0.53729844814723
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1729	61/9376	1.15567607543449	MT1G/MT1E/FXYD2/ATP1A1/SLC39A4/MT1H/ATP2B1/ATP1B3/SLC31A1/MT1F/SLC26A6/MT1M/ATP7B	0.580006622306559
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1729	36/9376	1.20506394190605	PYGL/GPI/GYG2/G6PC3/HK1/PGM1/GYG1/GYS1	0.586144512535389
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	21/1729	103/9376	1.10561691757399	COL1A1/FXYD2/SLC1A5/ATP1A1/COL6A2/COL3A1/COL6A3/COL6A1/COL27A1/COL18A1/COL1A2/COL4A1/ATP1B3/SLC3A2/COL9A3/SLC36A4/COL4A2/COL21A1/SLC7A8/KCNK5/COL16A1	0.512483114520931
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1729	21/9376	1.29113993775648	ALDH2/ALDH1B1/ALDH3A2/PANK3/PPCDC	0.635078084208642
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1729	62/9376	1.13703613873393	HDAC1/HDAC2/HEY1/DLL1/DVL3/CTBP2/CTBP1/TLE3/ITCH/KAT2A/NCOR2/RFNG/APH1B	0.514754830438724
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1729	73/9376	1.1142714531323	MAP2K2/FGFR1/FGF7/IGF1/BAK1/CDK4/PTEN/E2F1/AKT1/E2F2/E2F3/BRAF/RAF1/AKT2/PIK3CB	0.466042216869462
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1729	73/9376	1.1142714531323	GRB2/MAP2K2/KIF5B/BAK1/CDK4/E2F1/AKT1/E2F2/PRKCA/ERBB2/E2F3/BRAF/RAF1/AKT2/PIK3CB	0.466042216869462
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	31/1729	157/9376	1.07074152799932	BIRC5/ACTG1/PPP1CC/ID1/BMP4/TEAD4/PPP1CB/PPP1CA/YWHAQ/YWHAB/ID2/FZD3/PPP2R1A/YWHAE/TGFB1/WWTR1/CCND3/PPP2R1B/DLG5/DLG3/CSNK1E/PRKCZ/MOB1A/DVL3/MYC/NF2/MOB1B/AXIN2/DLG1/TP53BP2/CCND2	0.425030351969983
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	40/1729	205/9376	1.05810492460043	HLA-G/CCNE1/HLA-C/CALR/CCNA2/CYCS/PDIA3/ISG15/MAPK13/PSMC5/PSMC4/HDAC1/PSMD11/BAK1/CDK4/PSMD14/PSMD2/E2F1/PSMC3/SAP30/AKT1/PSMD12/HDAC2/CCND3/E2F2/PSMD3/CDKN1B/E2F3/MAP2K6/IRAK1/TRAF5/MYC/MAPK14/AKT2/CASP3/CCNE2/PIK3CB/NCOR2/OAS3/CCND2	0.399962353752145
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/1729	89/9376	1.09674358757741	HMMR/LAMA4/COL1A1/LAMA1/COL6A2/COL6A3/COL6A1/COL1A2/COL4A1/FRAS1/COL9A3/ITGA5/COL4A2/DAG1/ITGB5/LAMB1/ITGAV/ITGB8	0.436030690601997
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1729	32/9376	1.18623481781377	ATG12/ATG10/ATG5/ATG4B/ATG9A/ATG4C/MTOR	0.501772715625537
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1729	22/9376	1.23245175876755	ALDH2/ALDH1B1/ALDH3A2/ALDH9A1/ALDH3B2	0.519018793556497
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1729	48/9376	1.12974744553692	CLDN10/EPCAM/CLDN6/CLDN7/CD63/CLDN3/CHMP4A/LDLR/TGOLN2/CHMP7	0.428511770686131
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/1729	48/9376	1.12974744553692	FXYD2/ATP1A1/G6PC3/ATP1B3/SLC37A4/HK1/AKT1/AKT2/PIK3CB/PLCB3	0.428511770686131
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1729	60/9376	1.08455754771544	CDC42/MAP2K2/MAPK13/RAC3/AKT1/PRKCA/PPP3CA/RAF1/MAPK14/AKT2/PIK3CB/PXN	0.312428651516785
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1729	76/9376	1.07028705366656	SCD/PPARG/FABP7/HMGCS1/SLC27A2/CPT1C/PLTP/SLC27A5/PPARD/FADS2/ACSL4/PCK2/ACAA1/SLC27A6/SLC27A4	0.292535280296969
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/1729	82/9376	1.05810492460043	HLA-G/HSPA5/HLA-C/CALR/HSP90AB1/HSPA8/HSP90AA1/CANX/PDIA3/NFYB/HSPA2/HSPA4/PSME3/RFXANK/CREB1/RFXAP	0.251278958785466
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1729	29/9376	1.12195608384356	TEAD4/WWTR1/CSNK1E/MOB1A/NF2/MOB1B	0.312754766730197
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	44/1729	233/9376	1.02404575320771	ENO1/ACTG1/TPM2/MYL4/LMNB1/LMNB2/COL1A1/LBR/TNNI2/TPM1/LAMA1/NID1/ATP1A1/DSC2/TPM4/COL6A2/VCAN/COL3A1/COL6A3/COL6A1/COL27A1/DCN/DSP/TPM3/COL1A2/DIAPH3/COL4A1/ATP1B3/COL9A3/ITGA5/COL4A2/SGCB/DSG2/VCL/MYL5/DAG1/SYNE2/ITGB5/ANK3/TLN1/ITGAV/SPTBN1/INF2/ITGB8	0.176729714474766
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	20/1729	104/9376	1.04284379588023	PLA2G2A/AGPAT5/CHPT1/AGPAT4/LYPLA1/PTDSS2/CHKA/PLA2G12A/PISD/GPAM/PLA2G10/LCLAT1/GPD1L/PEMT/DGKD/ETNK1/PHOSPHO1/ETNK2/LPGAT1/DGKZ	0.208908201130574
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	15/1729	78/9376	1.04284379588023	CALM3/CALM1/PYCARD/C1R/RHOA/MAPK13/ITGA5/GNAI3/C1S/NOS2/IRAK1/CFL2/MAPK14/GNAI1/CASP3	0.180666679100557
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1729	46/9376	1.06098020972163	ALAS2/UROS/CP/HMBS/BLVRB/MMAB/GUSB/CPOX/HCCS	0.197135390440987
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	29/1729	154/9376	1.0211743144074	CALM3/CALM1/TPM2/MYL4/PPP1CC/FXYD2/PPP1CB/PPP1CA/TPM1/ATP1A1/TPM4/MAPK13/ADCY5/TPM3/ATP2B1/PPP2R1A/ATP1B3/PPP2R5C/GNAI3/AKT1/PPP2R1B/ATP2A2/PRKCA/CREB1/MAPK14/AKT2/GNAI1/PLCB3/PPP2R3C	0.125978011412302
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1729	101/9376	1.02012838646502	MMP2/COL1A1/CDC42/COL3A1/MAPK13/COL1A2/COL4A1/CDK4/COL4A2/AKT1/TGFB1/PRKCA/CDKN1B/PRKCZ/MAPK14/AKT2/CASP3/PIK3CB/PLCB3	0.0967053007233587
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7/1729	36/9376	1.05443094916779	AKR1B1/DCXR/UGDH/GUSB/CRYL1/RPE/SORD	0.155582702011117
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	6/1729	31/9376	1.04957182036978	ALDH2/ALDH1B1/ALDH3A2/UGDH/ALDH9A1/GUSB	0.13145092638849
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/1729	212/9376	0.997588310398638	CALM3/CALM1/ACTG1/ID1/PGF/CDC42/MAP2K2/RHOA/MAPK13/ENAH/ADCY5/FGFR1/FGF7/RAC3/IGF1/FLT4/MAGI1/RALB/GNAI3/AKT1/EVL/SIPA1L2/PRKCA/FGFR3/RALA/TLN1/PRKCZ/MAP2K6/BRAF/PRKD3/EFNA3/CRK/CRKL/RAF1/MAPK14/AKT2/GNAI1/PIK3CB/PLCB3	-0.0168882399465201
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1729	37/9376	1.0259328154065	MIF/GSTZ1/COMT/ADH5/FAH/GOT1/ALDH3B2	0.0751515483428362
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1729	37/9376	1.0259328154065	HBA2/HBA1/LAMA4/HBB/THOP1/PRKCA/PLCB3	0.0751515483428362
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1729	37/9376	1.0259328154065	MAP2K2/PPARG/TPM3/NCOA4/BAK1/BRAF/MYC	0.0751515483428362
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1729	26/9376	1.04284379588023	PLA2G2A/PLA2G12A/PLA2G10/FADS2/ACAA1	0.104017497194355
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1729	15/9376	1.08455754771544	ST3GAL1/SLC33A1/ST6GALNAC4	0.155838398335261
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	29/1729	158/9376	0.995321800118602	RPS6/EIF4B/GRB2/EIF4EBP1/MAP2K2/RHOA/FZD3/EIF4E/CAB39L/RPS6KB2/SEH1L/SLC3A2/IGF1/PTEN/DDIT4/AKT1/LRP6/PRKCA/SEC13/ATP6V1A/BRAF/DVL3/FNIP2/RAF1/AKT2/TTI1/PIK3CB/RPS6KB1/MTOR	-0.0281985355803674
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/1729	98/9376	0.996022237697855	MYO10/CDC42/ARPC1A/MARCKSL1/ACTR2/RPS6KB2/ARPC4/AKT1/DNM2/PRKCA/CFL2/CRK/CRKL/RAF1/AKT2/PIK3CB/RPS6KB1/DOCK1	-0.0188218483992305
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1729	126/9376	0.989873952279967	ACTG1/PPP1CC/COL1A1/PPP1CB/PPP1CA/RHOA/COL3A1/MAPK13/ADCY5/COL1A2/GNAI3/AKT1/FYN/PPP1R12A/ORAI1/TLN1/PRKCZ/MAPK14/AKT2/GNAI1/PIK3CB/PLCB3/STIM1	-0.0544116587481034
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	31/1729	170/9376	0.988861293505256	TUBA1C/TUBA1B/CLDN10/ACTG1/JAM3/CLDN6/CDC42/CLDN7/RAB13/RHOA/MYL6B/CLDN3/ARPC1A/EPB41L4B/ACTR2/ARPC4/PPP2R1A/RAB8B/CDK4/MAGI1/CGNL1/HSPA4/ARHGAP17/PPP2R1B/DLG3/ERBB2/PRKCZ/RAP2C/NF2/DLG1/MARVELD3	-0.0696885335151437
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/1729	99/9376	0.985961407014039	GRB2/EIF4EBP1/MAP2K2/CHPT1/LYPLA1/SLC44A1/RAC3/RPS6KB2/CHKA/AKT1/PRKCA/DGKD/RAF1/AKT2/PIK3CB/RPS6KB1/DGKZ/MTOR	-0.0667690184221429
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1729	55/9376	0.985961407014039	CERS4/GM2A/SMPD4/CERS5/SMPD2/DEGS2/KDSR/SGPP1/SPTLC1/GLA	-0.0496490866337963
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1729	16/9376	1.01677270098323	MIF/GOT1/ALDH3B2	0.0319273344250513
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	27/1729	150/9376	0.976101792943898	CCNE1/GRB2/MAP2K2/FZD3/FGF7/RPS6KB2/BAK1/E2F1/AKT1/TGFB1/LRP6/E2F2/CDKN1B/ERBB2/E2F3/BRAF/DVL3/FRAT2/MYC/RAF1/MLH1/AXIN2/AKT2/CCNE2/PIK3CB/RPS6KB1/MTOR	-0.140294877343466
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/1729	200/9376	0.976101792943898	TUBA1C/TUBB/TUBA1B/TMBIM6/CLDN10/ACTG1/GAPDH/TUBB4B/NCL/CYCS/MYO1B/PYCARD/MYO10/CLDN6/CDC42/CLDN7/TMED10/TUBB6/RHOA/CLDN3/MAPK13/IL1R1/ARPC1A/ACTR2/ARPC4/BAIAP2L1/BRK1/BAK1/ABCF2/FYN/ABL1/IRAK1/NCKAP1/MYO1E/MAPK14/CASP3	-0.162439335677059
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/1729	67/9376	0.971245565118307	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/MAP2K2/PRKCA/BRAF/PPP3CA/GRIN2D/RAF1/PLCB3	-0.112312556429617
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	32/1729	178/9376	0.974883188957701	CACYBP/RHOA/DKK1/RUVBL1/FZD3/RAC3/APCDD1/LGR4/PPARD/CCND3/LRP6/PRKCA/RNF43/CSNK1E/DVL3/CTBP2/CUL1/PPP3CA/FRAT2/LGR5/CSNK2A1/CTBP1/TLE3/NLK/MYC/PRICKLE3/AXIN2/GPC4/CHD8/PLCB3/CCND2/FRZB	-0.160866416181432
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	28/1729	156/9376	0.973320876154884	CLDN10/CYCS/GRB2/CLDN6/CLDN7/YWHAQ/YWHAB/MAP2K2/CLDN3/LDLR/EIF2S1/PPP2R1A/YWHAE/BAK1/CDK4/E2F1/AKT1/E2F2/PPP2R1B/PSME3/E2F3/BRAF/MYC/RAF1/AKT2/CASP3/PIK3CB/OAS3	-0.159773957099521
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1729	45/9376	0.964051153524838	ABCG2/ABCA7/ABCD3/ABCB10/ABCB7/DEFB1/ABCD4/ABCC5	-0.114938284608917
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1729	17/9376	0.956962542101861	SEPHS1/TXNRD1/PAPSS1	-0.0844488884627985
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1729	23/9376	0.943093519752559	THOP1/ANPEP/NLN/ENPEP	-0.129923516082412
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1729	69/9376	0.943093519752559	GRB2/MAP2K2/MAPK13/RAC3/AKT1/FYN/PRKCA/MAP2K6/RAF1/MAPK14/AKT2/PIK3CB	-0.225589562930517
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1729	69/9376	0.943093519752559	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/ADCY5/HDAC1/HDAC2/PRKCA/PPP3CA/CREB1/GRIN2D	-0.225589562930517
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1729	103/9376	0.947671643634853	LAMA4/COL1A1/LAMA1/SERPINB9/COL3A1/IL1R1/COL1A2/COL4A1/COL4A2/VCL/TGFB1/PRKCA/ARG2/LAMB1/NOS2/CASP3/PIK3CB/PLCB3	-0.253911964709478
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	21/1729	120/9376	0.948987854251012	CALM3/CALM1/GRB2/CDC42/MAP2K2/RHOA/MAPK13/SH2B2/YWHAE/AKT1/ABL1/SORT1/ARHGDIA/BRAF/IRAK1/CRK/CRKL/RAF1/MAPK14/AKT2/PIK3CB	-0.267417689185141
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/1729	137/9376	0.949977414057322	TUBA1C/TUBA1B/BIRC5/ACTG1/CYCS/LMNB1/LMNB2/MAP2K2/EIF2S1/HTRA2/BAK1/CASP6/ENDOG/CTSV/DFFA/AKT1/AIFM1/ERN1/RAF1/AKT2/ATM/CASP3/PARP2/PIK3CB	-0.280447471516446
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	41/1729	232/9376	0.958337488283042	ACTG1/PPP1CC/CDC42/PPP1CB/PPP1CA/MAP2K2/ITGAE/RHOA/ARPC1A/ENAH/FGFR1/ACTR2/FGF7/IQGAP1/RAC3/ARPC4/DIAPH3/BRK1/ITGA5/AKT1/VCL/MYL5/GNG12/FGFR3/PPP1R12A/ITGB5/ITGAV/BRAF/ABI2/CFL2/NCKAP1/CRK/ITGB8/CRKL/RAF1/PAK4/AKT2/PIK3CB/IQGAP3/PXN/DOCK1	-0.305533561351935
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	17/1729	98/9376	0.940687668936863	CALM3/CALM1/IMPA2/PTEN/PRKCA/PIK3C2G/IP6K2/DGKD/INPP4B/PIK3C2A/PPIP5K2/INPP5A/MTMR4/PIK3CB/DGKZ/PLCB3/MTMR2	-0.280652190522652
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	27/1729	155/9376	0.944614638332805	CCNE1/CYP11A1/MAP2K2/LDLR/FZD3/ADCY5/WDR5/FH/CDK4/GNAI3/E2F1/E2F2/CDKN1B/ORAI1/E2F3/BRAF/DVL3/NR4A1/CREB1/MEN1/AXIN2/GNAI1/CCNE2/PLCB3/ARNT/RBBP5/CDKN2C	-0.3306050048413
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1729	93/9376	0.932952729217585	CALM3/CGA/MMP2/CALM1/GRB2/CDC42/MAP2K2/MAPK13/ADCY5/MAP3K4/PRKCA/MAP2K6/MMP14/RAF1/MAPK14/PLCB3	-0.308969772441945
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1729	53/9376	0.920850748060281	FXYD2/ATP1A1/PTH1R/ATP2B1/ATP1B3/DNM2/PRKCA/AP2A1/PLCB3	-0.274754299374654
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/1729	116/9376	0.934963403202968	MMP2/CLDN10/ACTG1/JAM3/CLDN6/CDC42/CLDN7/CYBA/RHOA/CLDN3/MAPK13/THY1/GNAI3/VCL/MYL5/PRKCA/MAPK14/GNAI1/PIK3CB/PXN	-0.33513431526982
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1729	122/9376	0.933430676312471	GRB2/CDC42/MAP2K2/CBLB/RHOA/MAPK13/MAP3K8/PPP2R1A/CDK4/PPP2R5C/AKT1/PPP2R1B/FYN/PPP3CA/RAF1/MAPK14/PAK4/DLG1/AKT2/PIK3CB/PPP2R3C	-0.351906186874176
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1729	71/9376	0.916527505111641	CGA/GRB2/ELF5/MAP2K2/MAPK13/AKT1/PRLR/RAF1/MAPK14/AKT2/PIK3CB/CCND2	-0.335700485688621
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	24/1729	140/9376	0.929620755184665	CALM3/CALM1/MYL4/RPS6/TFAM/MAP2K2/GNB2/ADCY5/RPS6KB2/GNB1/GNAI3/GNB5/AKT1/GNG12/NOS2/ACTA2/GNG11/RAF1/HDAC5/AKT2/GNAI1/RPS6KB1/MTOR/PLCB3	-0.398936936111286
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1729	60/9376	0.903797956429535	MAP2K2/PPP2R1A/IGF1/GNAI3/PPP2R1B/PRKCA/BRAF/RAF1/GNAI1/PLCB3	-0.355453481775823
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/1729	89/9376	0.913952989647845	TUBA1C/TUBB/TUBA1B/CDK1/TUBB4B/GRB2/MAP2K2/TUBB6/ADCY5/GJA1/GNAI3/PRKCA/RAF1/GNAI1/PLCB3	-0.387820405337613
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/1729	163/9376	0.931521820123693	CCNE1/BIRC5/CCNA2/CYCS/GRB2/YWHAQ/YWHAB/MAP2K2/VDAC3/MAPK13/E2F1/AKT1/DDX3X/TGFB1/E2F2/PRKCA/E2F3/MAP2K6/BRAF/IRAK1/CREB1/MYC/RAF1/MAPK14/AKT2/CASP3/CCNE2/PIK3CB	-0.419356196666891
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1729	31/9376	0.874643183641486	ALDH2/ALDH1B1/ALDH3A2/ALDH9A1/ALDH3B2	-0.332412034024941
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	13/1729	78/9376	0.903797956429535	TPI1/IMPA2/PTEN/PIK3C2G/IP6K2/INPP4B/PIK3C2A/PPIP5K2/INPP5A/MTMR4/PIK3CB/PLCB3/MTMR2	-0.405671425173179
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1729	44/9376	0.862716231137284	DYNLL1/DYNC1LI1/NSF/ARHGDIA/CREB1/DCTN2/DCTN5	-0.434006022758094
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1729	38/9376	0.856229642933244	FXYD2/ATP1A1/ATP1B3/IGF1/PRKCA/PIK3CB	-0.422252086839481
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1729	56/9376	0.871519457985623	HSPA8/CYCS/HSPD1/PYCARD/BNIP3/SAR1A/SAR1B/RAB1B/CASP3	-0.458522875331379
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1729	32/9376	0.847310584152689	BIRC5/CYCS/HTRA2/BAK1/CASP3	-0.411391294798577
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1729	26/9376	0.834275036704187	SLC19A1/SLC5A6/SLC19A2/ABCD4	-0.402352208773597
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	43/1729	253/9376	0.921659576121819	ACTG1/CYCS/PYCARD/BNIP3/CDC42/VDAC1/UBE2V2/RHOA/U2AF1/MAPK13/IL1R1/ARPC1A/CBX3/ACTR2/ATG12/RPS6KB2/ARPC4/UBE2D2/UBE2N/PPID/ITGA5/FNBP1/HK1/AKT1/GLMN/VCL/MYL5/TLN1/CUL1/ELMO1/CRK/TRAF5/CRKL/ATG5/MAPK14/AKT2/ATM/PIK3CB/RPS6KB1/MTOR/PXN/PLCB3/DOCK1	-0.600640939104437
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1729	33/9376	0.821634505845032	VTI1B/STX2/VTI1A/GOSR2/YKT6	-0.488047650766693
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/1729	122/9376	0.888981596488068	GRB2/MAP2K2/MAPK13/ADCY5/IGF1/GNAI3/AKT1/PRKCA/MAP2K6/CREB1/CRK/CRKL/RAF1/MAPK14/AKT2/GHR/GNAI1/PIK3CB/MTOR/PLCB3	-0.586877872398479
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1729	93/9376	0.874643183641486	ACTG1/ACP1/CDC42/RHOA/FGFR1/IQGAP1/RAC3/VCL/MYL5/FYN/HEG1/SNAI1/ERBB2/CSNK2A1/NLK	-0.57767402867195
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1729	52/9376	0.834275036704187	CGA/CYP11A1/LDLR/ACOT4/ADCY5/CYP2J2/IGF1/HSD17B7	-0.569804743911807
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1729	76/9376	0.856229642933244	CALM3/CALM1/ACTG1/GAST/CA2/ATP1A1/ADCY5/ATP1B3/GNAI3/PRKCA/GNAI1/PLCB3	-0.598373377584489
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	40/1729	238/9376	0.911392897239868	RPL36/RPS9/RPSA/RPL29/RPL5/RPS5/RPL28/RPL7A/RPL15/RPS6/RPL19/RPS15/RPL18A/RPLP0/RPS3A/RPL8/RPS18/CFD/RPL6/RPL14/RPL22L1/RPL13A/RPL4/RPS13/RPS19/RPL3/RPS7/RPL35A/RPL22/ISG15/C1R/MAPK13/RSL24D1/RPL26L1/PRKCA/C1S/IRAK1/MAPK14/PIK3CB/OAS3	-0.658368475997065
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/1729	250/9376	0.911028340080972	HLA-G/HLA-C/CAV1/HSPA8/CDC42/SNF8/CBLB/RHOA/SNX5/CHMP4A/LDLR/MVB12A/ARPC1A/ACTR2/VPS29/ARPC4/SPG21/KIF5B/VPS25/VPS28/SH3GL3/RAB10/DNM2/ARF3/FGFR3/ARFGAP2/EPS15L1/EPN1/AP2A1/PSD3/IL2RB/PRKCZ/RAB4A/ZFYVE16/CBLC/ITCH/ACAP2/CHMP6/CHMP7/GRK5/RAB11FIP5/LDLRAP1	-0.677983391327621
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/1729	112/9376	0.871519457985623	HSPA8/CYCS/LAMA4/PPIF/LAMA1/MAPK13/LDLR/GNAI3/AKT1/TGFB1/LAMB1/NOS2/MAP2K6/IRAK1/MAPK14/AKT2/GNAI1/CASP3	-0.650406223124135
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1729	28/9376	0.774683962653887	CA2/ATP6V0A4/ATP6V1A/ATP6V0E2	-0.567739823229529
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	36/1729	217/9376	0.899632988888385	BIRC5/KPNA2/HSP90AB1/MGST1/HSP90B1/HSP90AA1/KPNB1/GRB2/EIF4EBP1/MGST3/PTGES3/MAP2K2/GSTA4/GSTO1/ADCY5/CDC25A/FGF7/RPS6KB2/CDC6/GNAI3/E2F1/AKT1/CCND3/DLL1/PRKCA/CREB1/KPNA4/MYC/RAF1/AKT2/GNAI1/PIK3CB/RPS6KB1/MTOR/ARNT/GSTO2	-0.711269880459799
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	27/1729	166/9376	0.882019692419185	CALM3/CALM1/PPP1CC/PPIF/FXYD2/VDAC1/PPP1CB/PPP1CA/ATP1A1/MAP2K2/VDAC3/RHOA/ADCY5/SLC25A6/ATP2B1/ATP1B3/VDAC2/GNAI3/AKT1/ATP2A2/PPP1R12A/PPP3CA/CREB1/RAF1/AKT2/GNAI1/PLCB3	-0.729241444616865
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/1729	90/9376	0.843544759334233	EIF4EBP1/PPARG/ADCY5/EIF4E/RPS6KB2/IGF1/AKT1/CREB1/ATG5/ADIPOR2/AKT2/PIK3CB/RPS6KB1/MTOR	-0.709144305414721
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/1729	90/9376	0.843544759334233	MAP2K2/MAPK13/RPS6KB2/PTEN/AKT1/MAP2K6/PPP3CA/CSNK2A1/RAF1/MAPK14/AKT2/PIK3CB/RPS6KB1/MTOR	-0.709144305414721
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/1729	138/9376	0.864502393106512	ACTG1/PYCARD/CDC42/MAP2K2/RHOA/MAPK13/ARPC1A/ACTR2/RAC3/ARPC4/ITGA5/AKT1/MAP2K6/IRAK1/ELMO1/CRK/CRKL/MAPK14/AKT2/PIK3CB/PXN/DOCK1	-0.762464765080434
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1729	16/9376	0.677848467322152	ST3GAL1/GLA	-0.613225009474262
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1729	86/9376	0.819723727924462	ACTG1/LAMA1/DSC2/DSP/GJA1/ITGA5/SGCB/DSG2/ATP2A2/DAG1/ITGB5/ITGAV/ITGB8	-0.79857834099698
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/1729	134/9376	0.849839869478518	CALM3/CALM1/PPP1CC/PLA2G2A/PPP1CB/PPP1CA/MAP2K2/RHOA/MYL6B/RAMP1/PPP1R14A/ADCY5/RAMP2/PLA2G12A/PLA2G10/PRKCA/PPP1R12A/BRAF/ACTA2/RAF1/PLCB3	-0.83245668252107
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1729	43/9376	0.756668056545657	ACAT2/PLA2G2A/ACAT1/PLA2G12A/PLA2G10/SLC27A4	-0.760431868891144
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1729	30/9376	0.723038365143628	PLA2G2A/CYP2J2/PLA2G12A/PLA2G10	-0.722445254798939
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1729	105/9376	0.826329560164147	ACTG1/TPM2/TPM1/LAMA1/TPM4/ADCY5/TPM3/IGF1/ITGA5/SGCB/TGFB1/ATP2A2/DAG1/ITGB5/ITGAV/ITGB8	-0.850931994024427
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/1729	99/9376	0.821634505845032	CALM3/CALM1/PPP1CC/PPP1CB/PPP1CA/MAPK13/IL1R1/ADCY5/CYP2J2/IGF1/PRKCA/MAP2K6/MAPK14/PIK3CB/PLCB3	-0.848324969390943
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1729	99/9376	0.821634505845032	ACTG1/TPM2/TPM1/LAMA1/TPM4/TPM3/IGF1/ITGA5/SGCB/TGFB1/ATP2A2/DAG1/ITGB5/ITGAV/ITGB8	-0.848324969390943
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/1729	50/9376	0.75919028340081	HBA2/HBA1/GYPC/GYPA/GYPB/HBB/TGFB1	-0.811799712062786
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1729	63/9376	0.774683962653887	PTGDS/PLA2G2A/PTGES3/CYP2J2/PTGES2/PTGR1/CBR1/PLA2G12A/PLA2G10	-0.853208488670405
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	14/1729	94/9376	0.807649237660436	HSP90AB1/HSP90B1/HSP90AA1/SRSF1/MAPK13/ANAPC5/ELAVL1/IL17D/TRAF4/TRAF5/MAPK6/MAPK14/CASP3/USP25	-0.891198909425431
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1729	17/9376	0.637975028067907	CA2/CA12	-0.710372033306433
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1729	184/9376	0.854678502275756	CDC42/RHOA/FZD3/ENAH/ROBO1/SEMA6A/RAC3/FES/EPHB3/GNAI3/EPHB4/RGS3/MYL5/FYN/PRKCA/ABL1/SEMA4G/BOC/SEMA4B/PLXNA1/PRKCZ/PPP3CA/CFL2/EFNA3/RAF1/PAK4/GNAI1/PIK3CB/SRGAP1	-0.946610589668097
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1729	51/9376	0.744304199412559	PLA2G2A/PAFAH1B3/CHPT1/PLA2G12A/PAFAH1B1/PLA2G10/AGPS	-0.870606395179312
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1729	70/9376	0.774683962653887	LEP/SLC2A1/CPT1C/G6PC3/AKT1/ACSL4/PCK2/ADIPOR2/AKT2/MTOR	-0.899698901671445
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	34/1729	216/9376	0.853586958850117	CALM3/HSPA5/CALM1/HSP90AB1/HSP90B1/HSPA8/CYCS/HSP90AA1/HSPD1/PYCARD/CDC42/CYBA/RHOA/MAPK13/LDLR/PPARG/EIF2S1/XBP1/CYP2J2/HSPA2/CASP6/HSPA4/AKT1/PRKCA/MAP2K6/IRAK1/PPP3CA/ERN1/MAPK14/AKT2/CASP3/POU2F1/PIK3CB/PLCB3	-1.03513380051027
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1729	65/9376	0.750847533033768	CGA/MAP2K2/KISS1R/AKT1/PRKCA/RAF1/AKT2/PIK3CB/PLCB3	-0.958431980031545
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1729	139/9376	0.819270090000874	KRT19/CALM3/MMP2/CALM1/HSP90AB1/HSP90B1/HSPA8/HSP90AA1/GRB2/MAP2K2/KRT10/FKBP4/ADCY5/GNAI3/AKT1/CREB1/RAF1/AKT2/GNAI1/PIK3CB/PLCB3	-1.02072687687569
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	26/1729	169/9376	0.834275036704187	HMGB1/BNIP3/MAP2K2/EIF2S1/ATG12/RPS6KB2/PTEN/DDIT4/AKT1/WDR45B/ATG10/ERN1/WDR41/RAF1/ATG5/MTMR4/AKT2/ATG4B/ATG9A/VPS33A/VPS16/PIK3CB/YKT6/RPS6KB1/ATG4C/MTOR	-1.0337363833998
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/1729	115/9376	0.801629491789675	GCM1/PDE4D/RHOA/ADCY5/FGFR1/PTH1R/GNAI3/LRP6/PRKCA/MMP15/BRAF/CREB1/PDE4C/MMP14/RAF1/GNAI1/PLCB3	-1.01773491463491
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1729	59/9376	0.735293252688436	CGA/ADCY5/GNAI3/ABHD5/AKT1/AKT2/GNAI1/PIK3CB	-0.969818712096747
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/1729	97/9376	0.782670395258567	CALM3/CALM1/GNB2/ADCY5/GNB1/GNAI3/GNB5/GNG12/PRKCA/GNG11/CREB1/GRIN2D/GNAI1/PLCB3	-1.02303798610287
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/1729	79/9376	0.755071710434802	SLC1A2/ATP6V0B/SLC6A11/ATP6V0A4/NSF/DNM2/ATP6V1A/STX2/AP2A1/ATP6V0E2/UNC13B	-1.03948605987362
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/1729	98/9376	0.774683962653887	CALM3/CALM1/CYP11A1/ATP1A1/LDLR/ADCY5/ATP2B1/ATP1B3/PRKCA/ORAI1/NR4A1/CREB1/PRKD3/PLCB3	-1.06614321689292
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	31/1729	201/9376	0.836350347740764	CCNA2/ETV5/FUS/ID2/PPARG/DDX5/DUSP6/EWSR1/ETV4/HDAC1/IGF1/BAK1/MYCN/LMO2/HDAC2/MLF1/TAF15/REL/CDKN1B/SS18/IL2RB/CCNT1/MEIS1/PRCC/TCF3/MYC/MEN1/ATM/SIX4/CCND2/CDKN2C	-1.11518692473614
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1729	19/9376	0.570819761955496	GUSB/HYAL3	-0.890401313092132
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1729	136/9376	0.797468785084884	CCNE1/HSPA8/CYCS/CBLB/EIF2S1/BAK1/CDK4/AKT1/CCND3/CDKN1B/RCHY1/IL2RB/IRAK1/CSNK2A1/AKT2/CASP3/CCNE2/PIK3CB/OAS3/CCND2	-1.13126154974915
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/1729	155/9376	0.804671728950167	HLA-G/TUBA1C/TUBB/TUBA1B/HLA-C/CALR/ACTG1/TUBB4B/CANX/CYBA/TUBB6/C1R/SEC61G/SEC61B/ATP6V0B/DYNC1LI1/SEC61A1/ITGA5/ATP6V0A4/ATP6V1A/ITGB5/ITGAV/ATP6V0E2	-1.16594894485128
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1729	69/9376	0.707320139814419	CALM3/CALM1/ADCY5/GNAI3/ORAI1/PPP3CA/CREB1/GNAI1/PLCB3	-1.16024609940269
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/1729	56/9376	0.677848467322152	LRP2/CSNK1G2/BOC/CSNK1E/CUL1/EVC2/CCND2	-1.14969819351578
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1729	89/9376	0.731162391718276	GNB2/ADCY5/GNB1/GNAI3/SLC38A1/SLC6A11/GNB5/NSF/GNG12/PRKCA/GNG11/GNAI1	-1.21167150127722
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1729	102/9376	0.744304199412559	PLA2G2A/FXYD2/CA2/ATP1A1/RHOA/ADCY5/ATP2B1/ATP1B3/PLA2G12A/ATP2A2/RAB3D/PLA2G10/PRKCA/PLCB3	-1.23460412962848
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1729	83/9376	0.718682712341558	POLR2H/PYCARD/G3BP1/POLR2L/POLR1D/POLR3G/POLR2E/POLR3H/GSDMD/DNASE2/CASP3	-1.22403853053291
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1729	36/9376	0.602531970953024	GALNT2/GALNT1/ST3GAL1/ST6GALNAC4	-1.1361027295617
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1729	29/9376	0.560978041921781	CALM3/CALM1/GNB1	-1.12586601472311
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/1729	103/9376	0.73707794504933	CALR/MAPK13/PPP2R1A/GNAI3/AKT1/TGFB1/PPP2R1B/NOS2/IRAK1/MAPK14/AKT2/GNAI1/PIK3CB/PLCB3	-1.27577207035002
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1729	71/9376	0.687395628833731	JAM3/CDC42/MAPK13/ATP6V0B/ATP6V0A4/ATP6V1A/ATP6V0E2/MAPK14/CASP3	-1.25719782749105
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1729	91/9376	0.715092888603588	PDE4D/GNB2/ADCY5/GNB1/GNAI3/GNB5/GNG12/PRKCA/GNG11/PDE4C/GNAI1/GRK5	-1.29858571580085
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1729	173/9376	0.783639846615204	KPNA2/ACTG1/CYCS/PYCARD/VDAC1/MAP2K2/XPO1/FDPS/EIF2S1/SLC25A6/PABPN1/DNAJC3/BAK1/CDK4/RAE1/AKT1/CCND3/PRKCA/NUP98/CPSF4/RAF1/AKT2/CASP3/PIK3CB/OAS3	-1.36575629506859
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1729	72/9376	0.677848467322152	ISG15/MAPK13/PIN1/ATG12/DDX3X/SIKE1/AZI2/ATG5/MAPK14	-1.3047556585176
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1729	38/9376	0.570819761955496	ADA/ORAI1/RFXANK/RFXAP	-1.26049802505819
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/1729	196/9376	0.774683962653887	HLA-G/CALM3/HLA-C/CALM1/CYCS/MAP2K2/MAPK13/GNB2/BAK1/CDK4/GNB1/E2F1/GNB5/AKT1/E2F2/GNG12/E2F3/MAP2K6/GNG11/PPP3CA/CREB1/MYC/RAF1/MAPK14/AKT2/CASP3/PIK3CB/MTOR	-1.51578075743225
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1729	47/9376	0.576892312614597	PKM/HK1/PRKCZ/PIK3CB/MTOR	-1.38267429235109
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/1729	115/9376	0.707320139814419	GNB2/ADCY5/GNB1/GNAI3/GNB5/AKT1/FYN/GNG12/PRKCA/GNG11/CREB1/AKT2/GNAI1/PIK3CB/PLCB3	-1.50158667842655
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/1729	116/9376	0.701222552402226	SLC1A2/GNB2/ADCY5/GNB1/GNAI3/SLC38A1/GNB5/GNG12/PRKCA/GNG11/PPP3CA/GRIN2D/GNAI1/PLCB3/HOMER1	-1.53960355015553
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	27/1729	193/9376	0.758628336484895	CCR7/CXCL14/GRB2/CDC42/RHOA/GNB2/ADCY5/CCL21/RAC3/GNB1/GNAI3/GNB5/AKT1/GNG12/PRKCZ/BRAF/GNG11/ELMO1/CRK/CRKL/RAF1/AKT2/GNAI1/PIK3CB/GRK5/PXN/PLCB3	-1.61105451238335
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1729	49/9376	0.55334568760992	ADCY5/GNAI3/CREB1/GRIN2D/GNAI1	-1.49051438843048
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	48/1729	323/9376	0.805863193348936	CCNE1/STMN1/IGF2BP1/EZH2/GRB2/TPM1/CDCA5/MAP2K2/KIF23/RHOA/FZD3/CDC25C/HNRNPK/CDC25A/DNMT3B/HDAC1/CDC25B/BAK1/ITGA5/TRIM71/PTEN/E2F1/DDIT4/CCNG1/HDAC2/BRCA1/E2F2/PRKCA/FGFR3/ABL1/CDKN1B/SLC7A1/ERBB2/E2F3/EFNA3/CRK/SPRY2/MYC/CRKL/RAF1/HDAC5/PAK4/ATM/CASP3/CCNE2/PIK3CB/MTOR/CCND2	-1.68830331175018
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1729	34/9376	0.478481271050931	CSNK1E/CUL1/CREB1	-1.44852843971569
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/1729	144/9376	0.715506715506716	SCD/MAPK13/TRA2B/TRA2A/CPT1C/ADH5/ALDH2/FASN/AKT1/ALDH1B1/ALDH3A2/ALDH9A1/ACACA/MAP2K6/IRAK1/MAPK14/ADIPOR2/AKT2/CASP3	-1.63584803686675
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/1729	238/9376	0.774683962653887	CALM3/CALM1/PLA2G2A/PGF/GRB2/RALBP1/CDC42/MAP2K2/RHOA/GNB2/FGFR1/FGF7/RAC3/IGF1/FLT4/GNB1/RALB/PLA2G12A/GNB5/AKT1/GNG12/PLA2G10/PRKCA/REL/FGFR3/ABL1/RALA/GNG11/EFNA3/RAF1/NF1/PAK4/AKT2/PIK3CB	-1.67414317254939
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/1729	105/9376	0.671392767633369	TOMM20/PHB2/TOMM40/BNIP3/EIF2S1/PGAM5/SAMM50/E2F1/OPA1/HUWE1/MFN1/CSNK2A1/ATG9A	-1.6100748506935
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1729	105/9376	0.671392767633369	CALM3/CALM1/PYCARD/CBLB/RHOA/MAPK13/IL17D/AKT1/PPP3CA/RAF1/MAPK14/AKT2/PIK3CB	-1.6100748506935
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1729	79/9376	0.617785944901201	MGST1/MGST3/GSTA4/GSTO1/ADH5/CYP2S1/CBR1/ALDH3B2/GSTO2	-1.62213267756157
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1729	65/9376	0.583992525692931	CYP11A1/LDLR/ADCY5/ORAI1/NR4A1/CREB1/PLCB3	-1.60028464563461
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1729	17/9376	0.318987514033954	SLC27A5	-1.33629517815007
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1729	17/9376	0.318987514033954	DAG1	-1.33629517815007
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1729	101/9376	0.644291612504223	CALM3/CALM1/MAP2K2/FZD3/ADCY5/GNAI3/PRKCA/DVL3/CREB1/RAF1/GNAI1/PLCB3	-1.70897387340907
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1729	115/9376	0.660165463826791	GNB2/ADCY5/CYP2J2/GNB1/GNAI3/GNB5/GNG12/PRKCA/BRAF/GNG11/RAF1/GNAI1/CASP3/PLCB3	-1.74351256032237
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/1729	250/9376	0.75919028340081	LAPTM4B/CD63/VPS29/ATP6V0B/CLN6/GM2A/CD164/SLC36A4/SLC29A2/ATP6V0A4/CTSV/BLOC1S1/AP1S1/ATP6V1A/SORT1/KXD1/OSBPL1A/AP2A1/AP3D1/GUSB/ATP6V0E2/DNASE2/AP4M1/CLN5/SNAPIN/AP3B1/TTI1/VPS33A/VPS16/AP3M2/AP3M1/HYAL3/PPT2/MTOR/GLA	-1.83502239334578
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/1729	149/9376	0.691496423040047	GRB2/AGPAT5/MAP2K2/RHOA/ADCY5/AGPAT4/RALB/AKT1/FYN/DNM2/PRKCA/RALA/DGKD/RAF1/AKT2/PIK3CB/DGKZ/MTOR/PLCB3	-1.80493126351061
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1729	90/9376	0.602531970953024	SLC2A1/ABCG2/FXYD2/CA2/HMGCR/ATP1A1/LDLR/ADCY5/ATP1B3/SLC27A5	-1.80155160149102
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1729	38/9376	0.428114821466622	NT5C/NNMT/NT5M	-1.67962099416755
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	42/1729	300/9376	0.75919028340081	STMN1/HSPA8/PGF/GRB2/CDC42/MAP2K2/MAPK13/IL1R1/ECSIT/DUSP6/FGFR1/FGF7/MAP3K8/RAC3/IGF1/MAP3K4/CDC25B/FLT4/MKNK1/AKT1/TGFB1/GNG12/PRKCA/PPP5C/FGFR3/ERBB2/MAP4K4/MAP2K6/BRAF/IRAK1/NR4A1/PPP3CA/EFNA3/CRK/NLK/MYC/CRKL/RAF1/NF1/MAPK14/AKT2/CASP3	-2.01569574983849
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	19/1729	154/9376	0.669045240473812	CALM3/CALM1/ACTG1/PPP1CC/EEF2/PPP1CB/PPP1CA/MAP2K2/RHOA/MYL6B/ADCY5/GNAI3/EEF2K/PRKCA/PPP1R12A/PPP3CA/RAF1/GNAI1/PLCB3	-1.9690376590413
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1729	86/9376	0.567501042409243	SLC2A1/FXYD2/ATP1A1/TRPM4/ADCY5/ATP1B3/PRKCA/CREB1/PLCB3	-1.91586111726911
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/1729	181/9376	0.68908352479158	CALM3/CALM1/CYCS/HSPD1/RHOA/MAPK13/NFYB/HSPA9/ATP6V0B/ATP6V0A4/AKT1/TGFB1/RFXANK/NOS2/IRAK1/PPP3CA/CREB1/RAF1/MAPK14/AKT2/CASP3/CEBPG/RFXAP	-2.00837471909993
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1729	73/9376	0.519993344795075	MGST1/MGST3/GSTA4/GSTO1/ADH5/ALDH3B2/GSTO2	-1.95764873528644
NA	NA	hsa04517	IgSF CAM signaling	41/1729	299/9376	0.74359296749721	TUBA1C/TUBB/DYNLL1/TUBA1B/ACTG1/TUBB4B/JAM3/GRB2/CDC42/CLMP/MAP2K2/TUBB6/RHOA/MYL6B/MAPK13/ARPC1A/FGFR1/ROBO1/CNTNAP2/ACTR2/IQGAP1/ARPC4/ITGA5/MAGI1/PTPRS/AKT1/VCL/FYN/PRKCA/ABL1/ERC1/ANK3/PLXNA1/SPTBN1/MTSS1/MAPK14/PAK4/AKT2/PIK3CB/SRGAP1/PXN	-2.14255484918908
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1729	66/9376	0.492980703507019	CYP11A1/HSD17B12/SRD5A3/COMT/HSD17B7/DHRS11	-1.9654373521904
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/1729	119/9376	0.592405383205914	MAPK13/MAP3K8/PGAM5/AKT1/MAP2K6/CREB1/TRAF5/MMP14/ITCH/MAPK14/AKT2/CASP3/PIK3CB	-2.12767052913868
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/1729	187/9376	0.666973892980085	HSP90AB1/HSP90AA1/PYCARD/VDAC1/SUGT1/TXN2/CYBA/VDAC3/TRIP6/RHOA/MAPK13/ATG12/YWHAE/VDAC2/DHX33/GSDMD/MFN1/TRAF5/BRCC3/ATG5/MAPK14/OAS3/PLCB3	-2.18727076321635
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1729	91/9376	0.536319666452691	GRB2/MAP2K2/RAC3/IFITM1/AKT1/PPP3CA/RAF1/AKT2/PIK3CB	-2.11342094934417
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/1729	195/9376	0.667420029363349	HMGB1/ACTG1/PPIF/VDAC1/CYBA/MAP2K2/VDAC3/MAPK13/SLC25A6/HDAC1/VDAC2/AKT1/HDAC2/PRKCA/CLCN3/HDAC3/GSDMD/RAF1/MAPK14/HDAC5/AKT2/PIK3CB/MTOR/PLCB3	-2.23154676436125
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1729	44/9376	0.369735527630264	HLA-G/HLA-C/HSPD1	-1.99250486204568
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1729	70/9376	0.464810377592332	MGST1/MGST3/GSTA4/GSTO1/CBR1/GSTO2	-2.13704058147657
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1729	93/9376	0.524785910184892	CALM3/CALM1/FXYD2/ATP1A1/ADCY5/ATP2B1/ATP1B3/PRKCA/PLCB3	-2.18989956605198
NA	NA	hsa04382	Cornified envelope formation	27/1729	217/9376	0.674724741666289	KRT19/CLDN10/S100A13/CLDN6/CLDN7/S100A1/CLDN3/KRT10/PADI1/DSP/COL4A1/PPP2R1A/ELOVL1/PPP2R5C/COL4A2/ABHD5/DSG2/PPP2R1B/BLMH/PKP3/KDSR/KAZN/FURIN/SPTLC1/SLC27A4/S100A16/PPP2R3C	-2.30512487668148
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1729	78/9376	0.486660438077442	CYBA/MAPK13/MARCKSL1/TGFB1/NOS2/IRAK1/MAPK14	-2.16468573799438
Human Diseases	Substance dependence	hsa05034	Alcoholism	23/1729	191/9376	0.653005853336523	CALM3/CALM1/PPP1CC/GRB2/PPP1CB/PPP1CA/GNB2/ADCY5/HDAC1/GNB1/GNAI3/SLC29A2/GNB5/HDAC2/GNG12/HDAC3/BRAF/GNG11/CREB1/GRIN2D/RAF1/HDAC5/GNAI1	-2.30375792342339
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1729	63/9376	0.43037997925216	BMP4/FZD3/BAK1/DVL3/AXIN2	-2.15699087709459
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/1729	226/9376	0.671849808319301	CALM3/CGA/CALM1/PPP1CC/FXYD2/PPP1CB/PPP1CA/ATP1A1/PDE4D/MAP2K2/RHOA/ADCY5/RAC3/ATP2B1/ATP1B3/GNAI3/AKT1/ATP2A2/PPP1R12A/ORAI1/BRAF/CREB1/GRIN2D/PDE4C/RAF1/AKT2/GNAI1/PIK3CB	-2.37440022393429
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1729	39/9376	0.278091678901396	HLA-G/HLA-C	-2.14806916816446
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/1729	142/9376	0.572829690694776	GRB2/CYBA/MAPK13/IL1R1/PPARG/AKT1/TGFB1/ATP2A2/FYN/MAP2K6/PPP3CA/CREB1/MAPK14/AKT2/PIK3CB	-2.43886570096933
NA	NA	hsa04081	Hormone signaling	26/1729	219/9376	0.643801284031998	CGA/LEP/GAST/DIO2/RHOA/RAMP1/GNB2/ADCY5/PTH1R/IGF1/RAMP2/GNB1/GNAI3/GNB5/GNG12/ITGAV/GNG11/PRLR/SMAD5/EPOR/ADIPOR2/GHR/GNAI1/ACVR1/PIK3CB/PLCB3	-2.536152647902
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1729	68/9376	0.398734392542442	RDH11/ADH5/CYP2S1/PNPLA4/DHRS4	-2.36608434232868
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/1729	88/9376	0.431358115568642	TFPI/CFD/C1R/PROCR/CD55/C1S/SERPINB2	-2.54833587270203
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1729	54/9376	0.301265985476512	HLA-G/CGA/HLA-C	-2.44845319093684
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1729	45/9376	0.241012788381209	HLA-G/HLA-C	-2.42668949624969
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1729	168/9376	0.548734473546504	HMGB1/PYGL/PPIA/HSP90AB1/HSP90AA1/PYCARD/VDAC1/VDAC3/CHMP4A/SLC25A6/PGAM5/VDAC2/PPID/AIFM1/TRAF5/CHMP6/CHMP7	-2.80634934709829
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/1729	109/9376	0.447753116029311	MAP2K2/MAPK13/MAP3K8/AKT1/MAP2K6/IRAK1/MAPK14/AKT2/PIK3CB	-2.75749371508979
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/1729	109/9376	0.447753116029311	HSP90AB1/HSP90AA1/MAPK13/IL1R1/TGFB1/IL2RB/PPP3CA/MAPK14/MTOR	-2.75749371508979
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/1729	133/9376	0.489274081676139	HLA-G/HLA-C/GRB2/MAP2K2/RAC3/FYN/PRKCA/BRAF/PPP3CA/RAF1/CASP3/PIK3CB	-2.82062162819047
NA	NA	hsa04519	Cadherin signaling	51/1729	404/9376	0.684559838285737	KRT19/ACTG1/PPP1CC/MYO1B/TEAD4/CDC42/PPP1CB/PPP1CA/YWHAQ/YWHAB/DSC2/MAP2K2/RHOA/KRT10/MAPK13/ARPC1A/FZD3/ENAH/FGFR1/DSP/GJA1/MYO7A/ACTR2/RAC3/CIB2/ARPC4/YWHAE/FLT4/BRK1/DSG2/DSC3/VCL/EVL/WWTR1/LRP6/CDH3/PKP3/ERBB2/MOB1A/DVL3/ABI2/NCKAP1/MYO1E/PRICKLE3/RAF1/NF2/MAPK14/MOB1B/AXIN2/FAT2/APH1B	-3.08177286266195
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/1729	168/9376	0.516455975102592	LEP/GRB2/PTPN2/AKT1/CCND3/IL2RB/LIFR/PRLR/EPOR/MYC/RAF1/AKT2/GHR/PIK3CB/MTOR/CCND2	-3.00708425309763
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1729	41/9376	0.132263115575054	GRIN2D	-2.64764903141991
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/1729	160/9376	0.474493927125506	HLA-G/HLA-C/CLDN10/JAM3/CLDN6/CLDN7/CLDN3/VCAN/CNTNAP2/PTPRS/CDH3/SELL/ITGAV/ITGB8	-3.18789557750126
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/1729	105/9376	0.361519182571814	IL1R1/CCL21/ERC1/IRAK1/CSNK2A1/TRAF5/ATM	-3.12836056403163
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1729	99/9376	0.328653802338013	KRT19/CFD/C1R/KRT10/C1S/DEFB1	-3.19299282229734
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/1729	100/9376	0.325367264314633	GYPA/IL1R1/CD55/ANPEP/ITGA5/EPOR	-3.22496221558387
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/1729	93/9376	0.291547727880495	MAPK13/DLL1/IL2RB/PPP3CA/MAPK14	-3.26471659097199
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/1729	95/9376	0.285409880977748	ATP6V0B/ATP6V0A4/TGFB1/ATP6V1A/ATP6V0E2	-3.32858010267945
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1729	50/9376	0.108455754771544	TGFB1	-3.00550730173538
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/1729	254/9376	0.491039834595574	CALM3/CALM1/PPIF/VDAC1/VDAC3/FGFR1/FGF7/SLC25A6/ATP2B1/VDAC2/FLT4/ATP2A2/PRKCA/FGFR3/ORAI1/ERBB2/NOS2/MST1/PPP3CA/GRIN2D/PHKG2/PLCB3/STIM1	-3.91014810038415
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1729	100/9376	0.216911509543088	CCR7/CXCL14/CCL21/IL2RB	-3.74341572769447
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1729	66/9376	0.0821634505845032	TGFB1	-3.55795183714817
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1729	86/9376	0.12611134275761	KCNK5/PLCB3	-3.87110597574534
NA	NA	hsa04082	Neuroactive ligand signaling	13/1729	199/9376	0.35425246533419	SLC1A2/GNB2/ADCY5/GNB1/GNAI3/SLC6A11/GNB5/GNG12/PRKCA/GNG11/GRIN2D/GNAI1/PLCB3	-4.37800767811321
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1729	143/9376	0.227529555464778	SNRPD1/SSB/C1R/SNRPB/SNRPD3/C1S	-4.4260474200203
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	18/1729	298/9376	0.327550937229496	LEP/CCR7/CXCL14/BMP4/IL1R1/CCL21/IL17D/GDF11/ACVRL1/TGFB1/IL2RB/LIFR/IL36RN/PRLR/EPOR/ACVR2B/GHR/ACVR1	-5.60931753161783
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/1729	370/9376	0.278467478467478	CGA/TMEM97/LEP/GZMA/GAL/PGRMC1/CHRNA5/S1PR1/PTH1R/RLN2/S1PR3/TSPO/KISS1R/NPW/VGF/PRLR/GRIN2D/NMB/GHR	-6.73330661210765
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1729	449/9376	0.0362324347789123	CALM3/CALM1/GNB1	-9.95131100373065