ID	Description	GeneRatio	BgRatio	RichFactor	FoldEnrichment	pvalue	p.adjust
GO:0043021	ribonucleoprotein complex binding	93/3355	177/18639	0.525423728813559	2.91903811664856	1.8160624638477e-25	2.3717775777851e-22
GO:0140104	molecular carrier activity	109/3355	249/18639	0.437751004016064	2.43196451977807	2.47655067333898e-21	1.61718758969035e-18
GO:0016887	ATP hydrolysis activity	154/3355	417/18639	0.369304556354916	2.05170421040217	1.65230412714492e-20	7.19303063350424e-18
GO:0140097	catalytic activity, acting on DNA	130/3355	336/18639	0.386904761904762	2.1494837130083	1.79885614691744e-19	5.69811487190884e-17
GO:0008094	ATP-dependent activity, acting on DNA	94/3355	210/18639	0.447619047619048	2.48678731104961	2.18151411635101e-19	5.69811487190884e-17
GO:0003735	structural constituent of ribosome	79/3355	175/18639	0.451428571428571	2.50795145837769	8.87925391773831e-17	1.82339749127294e-14
GO:0043022	ribosome binding	59/3355	112/18639	0.526785714285714	2.92660474771131	9.77318716608775e-17	1.82339749127294e-14
GO:0140597	protein carrier chaperone	80/3355	188/18639	0.425531914893617	2.36408028664743	3.52632981173869e-15	5.75673341766341e-13
GO:0140098	catalytic activity, acting on RNA	133/3355	387/18639	0.343669250645995	1.90928499636086	5.50773375980301e-15	7.99233365589192e-13
GO:0004386	helicase activity	69/3355	155/18639	0.445161290322581	2.47313302245084	1.84505209226053e-14	2.40963803249225e-12
GO:0003689	DNA clamp loader activity	70/3355	160/18639	0.4375	2.43057004470939	3.47777116559634e-14	4.12906285660802e-12
GO:0003678	DNA helicase activity	42/3355	74/18639	0.567567567567568	3.15317194989326	8.4689005801222e-14	9.216986798033e-12
GO:0016853	isomerase activity	75/3355	180/18639	0.416666666666667	2.31482861400894	9.58454499103844e-14	9.62878135253554e-12
GO:0140658	ATP-dependent chromatin remodeler activity	68/3355	158/18639	0.430379746835443	2.39101284687506	2.1106938986381e-13	1.96897587972954e-11
GO:0003697	single-stranded DNA binding	56/3355	121/18639	0.462809917355372	2.57118153489919	7.3240148474917e-13	6.37677559388277e-11
GO:0015616	DNA translocase activity	65/3355	152/18639	0.427631578947368	2.37574515648286	1.01562146343166e-12	8.29001019526093e-11
GO:0061775	cohesin loader activity	65/3355	153/18639	0.42483660130719	2.36021741036206	1.45812093040748e-12	1.12017996183069e-10
GO:0140713	histone chaperone activity	68/3355	164/18639	0.414634146341463	2.30353676711134	1.777531179168e-12	1.28969762221856e-10
GO:0000510	H3-H4 histone complex chaperone activity	64/3355	151/18639	0.423841059602649	2.3546865901442	2.45471954761343e-12	1.45721078599234e-10
GO:0140584	chromatin extrusion motor activity	64/3355	151/18639	0.423841059602649	2.3546865901442	2.45471954761343e-12	1.45721078599234e-10
GO:0140665	ATP-dependent H3-H4 histone complex chaperone activity	64/3355	151/18639	0.423841059602649	2.3546865901442	2.45471954761343e-12	1.45721078599234e-10
GO:0140849	ATP-dependent H2AZ histone chaperone activity	64/3355	151/18639	0.423841059602649	2.3546865901442	2.45471954761343e-12	1.45721078599234e-10
GO:0140674	ATP-dependent histone chaperone activity	64/3355	152/18639	0.421052631578947	2.33919523099851	3.50133633610927e-12	1.9822152099347e-10
GO:0042393	histone binding	90/3355	247/18639	0.364372469635628	2.02430356528717	3.64266194781261e-12	1.9822152099347e-10
GO:0017116	single-stranded DNA helicase activity	34/3355	58/18639	0.586206896551724	3.25672439488155	5.5740329059533e-12	2.91187479007e-10
GO:0030515	snoRNA binding	22/3355	32/18639	0.6875	3.81946721311475	3.86098882739602e-10	1.93940438791508e-08
GO:0180051	translation factor activity	40/3355	84/18639	0.476190476190476	2.64551841601022	4.67208009961446e-10	2.25990244818388e-08
GO:0008135	translation factor activity, RNA binding	39/3355	83/18639	0.469879518072289	2.61045732856912	1.25424472587896e-09	5.85015575713545e-08
GO:0019843	rRNA binding	33/3355	65/18639	0.507692307692308	2.82052963430013	1.9376933113956e-09	8.72630160235397e-08
GO:0051539	4 iron, 4 sulfur cluster binding	26/3355	45/18639	0.577777777777778	3.2098956780924	2.71522269945155e-09	1.18202694849458e-07
GO:0140101	catalytic activity, acting on a tRNA	53/3355	139/18639	0.381294964028777	2.11831798346718	1.60979636930319e-08	6.66695338940274e-07
GO:0051536	iron-sulfur cluster binding	35/3355	76/18639	0.460526315789474	2.55849478390462	1.6788814314077e-08	6.66695338940274e-07
GO:0009378	four-way junction helicase activity	26/3355	48/18639	0.541666666666667	3.00927719821162	1.73565402174344e-08	6.66695338940274e-07
GO:0043138	3'-5' DNA helicase activity	26/3355	48/18639	0.541666666666667	3.00927719821162	1.73565402174344e-08	6.66695338940274e-07
GO:0051540	metal cluster binding	35/3355	77/18639	0.454545454545455	2.52526757891885	2.54730506931773e-08	9.50508691579701e-07
GO:0051082	unfolded protein binding	47/3355	121/18639	0.388429752066116	2.1579559310761	5.27030690325311e-08	1.81853619131544e-06
GO:0061749	forked DNA-dependent helicase activity	25/3355	47/18639	0.531914893617021	2.95510035830929	5.29129979096376e-08	1.81853619131544e-06
GO:1990518	single-stranded 3'-5' DNA helicase activity	25/3355	47/18639	0.531914893617021	2.95510035830929	5.29129979096376e-08	1.81853619131544e-06
GO:0000217	DNA secondary structure binding	22/3355	39/18639	0.564102564102564	3.13392181588903	8.25856750571822e-08	2.76556132370974e-06
GO:0036121	double-stranded DNA helicase activity	25/3355	48/18639	0.520833333333333	2.89353576751118	9.15613214881189e-08	2.98947714658708e-06
GO:0070182	DNA polymerase binding	15/3355	21/18639	0.714285714285714	3.96827762401533	1.18505039967926e-07	3.77481907800271e-06
GO:0016860	intramolecular oxidoreductase activity	26/3355	53/18639	0.490566037735849	2.72538312290864	2.4150867277796e-07	7.5097696820956e-06
GO:0000287	magnesium ion binding	73/3355	230/18639	0.317391304347826	1.76329553554072	2.88467116904427e-07	8.76135010877168e-06
GO:0017069	snRNA binding	26/3355	54/18639	0.481481481481481	2.674913065077	3.8618900415034e-07	1.14627918050078e-05
GO:0003743	translation initiation factor activity	25/3355	51/18639	0.490196078431373	2.72332778118699	4.18253224840777e-07	1.21386380364901e-05
GO:0000400	four-way junction DNA binding	13/3355	18/18639	0.722222222222222	4.0123695976155	7.05025574113242e-07	2.00165956476499e-05
GO:0003688	DNA replication origin binding	12/3355	16/18639	0.75	4.1666915052161	1.00520007011932e-06	2.7398571590482e-05
GO:0000049	tRNA binding	33/3355	80/18639	0.4125	2.29168032786885	1.00699191144191e-06	2.7398571590482e-05
GO:0031720	haptoglobin binding	9/3355	10/18639	0.9	5.00002980625931	1.64828915669602e-06	4.39319518090816e-05
GO:0016874	ligase activity	55/3355	167/18639	0.329341317365269	1.82968489251006	2.29268526256331e-06	5.98849390581537e-05
GO:0003713	transcription coactivator activity	76/3355	256/18639	0.296875	1.64931538748137	2.98270372504844e-06	7.63806091159462e-05
GO:0015631	tubulin binding	105/3355	385/18639	0.272727272727273	1.51516054735131	3.68567864623377e-06	9.25672367688713e-05
GO:0015036	disulfide oxidoreductase activity	20/3355	40/18639	0.5	2.77779433681073	4.05458341330143e-06	9.80608506994754e-05
GO:0140662	ATP-dependent protein folding chaperone	20/3355	40/18639	0.5	2.77779433681073	4.05458341330143e-06	9.80608506994754e-05
GO:0051087	protein-folding chaperone binding	46/3355	134/18639	0.343283582089552	1.90714238049692	4.31200557084601e-06	0.000100637544450654
GO:0015035	protein-disulfide reductase activity	18/3355	34/18639	0.529411764705882	2.94119400368195	4.31523927200354e-06	0.000100637544450654
GO:0043024	ribosomal small subunit binding	13/3355	20/18639	0.65	3.61113263785395	4.44037499124963e-06	0.000101739118220562
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	26/3355	60/18639	0.433333333333333	2.4074217585693	4.67900970272328e-06	0.000105358390892355
GO:0045296	cadherin binding	93/3355	334/18639	0.278443113772455	1.54691540912214	5.18380375363257e-06	0.000114746571224477
GO:0003727	single-stranded RNA binding	34/3355	89/18639	0.382022471910112	2.12235971801269	5.44988459892972e-06	0.000118625821436703
GO:0008186	ATP-dependent activity, acting on RNA	31/3355	79/18639	0.392405063291139	2.18004112509197	7.34472258434834e-06	0.000157249306478015
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	22/3355	48/18639	0.458333333333333	2.54631147540984	8.30842582867716e-06	0.000175012969875038
GO:0017070	U6 snRNA binding	11/3355	16/18639	0.6875	3.81946721311475	1.13021695474707e-05	0.000234295768714233
GO:0048027	mRNA 5'-UTR binding	14/3355	24/18639	0.583333333333333	3.24076005961252	1.15991522074387e-05	0.000236695199733046
GO:0031625	ubiquitin protein ligase binding	84/3355	302/18639	0.278145695364238	1.54526307478213	1.51405011222316e-05	0.000304207607163607
GO:0009055	electron transfer activity	40/3355	116/18639	0.344827586206897	1.91572023228326	1.56896210653167e-05	0.000308686355387728
GO:0016741	transferase activity, transferring one-carbon groups	64/3355	215/18639	0.297674418604651	1.65375662842685	1.58361300237196e-05	0.000308686355387728
GO:0140517	protein-RNA adaptor activity	13/3355	22/18639	0.590909090909091	3.2828478525945	1.9851837794984e-05	0.000373721423830067
GO:0044183	protein folding chaperone	29/3355	75/18639	0.386666666666667	2.1481609538003	1.99542630215566e-05	0.000373721423830067
GO:0044389	ubiquitin-like protein ligase binding	88/3355	322/18639	0.273291925465839	1.51829752571021	2.00310104656238e-05	0.000373721423830067
GO:0017056	structural constituent of nuclear pore	14/3355	25/18639	0.56	3.11112965722802	2.19897746071246e-05	0.000404487966716968
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	23/3355	54/18639	0.425925925925926	2.36626924987581	2.30258341755611e-05	0.000417663047684484
GO:0000339	RNA cap binding	12/3355	20/18639	0.6	3.33335320417288	3.3891444228204e-05	0.000606331865233348
GO:0003724	RNA helicase activity	29/3355	77/18639	0.376623376623377	2.0923645653899	3.56077794168284e-05	0.000628429188086188
GO:0140142	nucleocytoplasmic carrier activity	16/3355	32/18639	0.5	2.77779433681073	3.74885295520179e-05	0.000652800261265805
GO:0070063	RNA polymerase binding	24/3355	59/18639	0.406779661016949	2.25990047740534	3.85244238275678e-05	0.000662011809457942
GO:0031491	nucleosome binding	28/3355	74/18639	0.378378378378378	2.10211463326217	4.37559138202469e-05	0.000739481571379982
GO:0003712	transcription coregulator activity	124/3355	495/18639	0.250505050505051	1.39170302127083	4.41650555648075e-05	0.000739481571379982
GO:0008173	RNA methyltransferase activity	26/3355	67/18639	0.388059701492537	2.15590008230087	4.90530636773288e-05	0.000810927862817613
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	51/3355	167/18639	0.305389221556886	1.69661690032751	5.30465062471657e-05	0.00086598421448498
GO:0055106	ubiquitin-protein transferase regulator activity	17/3355	36/18639	0.472222222222222	2.62347242921013	5.48213370412668e-05	0.00088390945896166
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	26/3355	68/18639	0.382352941176471	2.12419566932585	6.59312651942076e-05	0.00105007600419067
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	23/3355	58/18639	0.396551724137931	2.20307826712575	8.88908907952595e-05	0.00139869281179047
GO:0008017	microtubule binding	75/3355	276/18639	0.271739130434783	1.50967083522322	9.6539434835216e-05	0.00150095835589038
GO:0003756	protein disulfide isomerase activity	11/3355	19/18639	0.578947368421053	3.21639344262295	0.000114614147636765	0.0017405357769025
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	11/3355	19/18639	0.578947368421053	3.21639344262295	0.000114614147636765	0.0017405357769025
GO:0070034	telomerase RNA binding	12/3355	22/18639	0.545454545454545	3.03032109470261	0.000121617678220168	0.00182566307764988
GO:0008168	methyltransferase activity	58/3355	204/18639	0.284313725490196	1.57953011308845	0.000156755119215501	0.00229779414620172
GO:0003725	double-stranded RNA binding	27/3355	75/18639	0.36	2.00001192250373	0.000159374263166761	0.00229779414620172
GO:0043175	RNA polymerase core enzyme binding	18/3355	42/18639	0.428571428571429	2.3809665744092	0.000159495717279386	0.00229779414620172
GO:0001098	basal transcription machinery binding	23/3355	60/18639	0.383333333333333	2.12964232488823	0.000163179374094158	0.00229779414620172
GO:0001099	basal RNA polymerase II transcription machinery binding	23/3355	60/18639	0.383333333333333	2.12964232488823	0.000163179374094158	0.00229779414620172
GO:0005344	oxygen carrier activity	9/3355	14/18639	0.642857142857143	3.5714498616138	0.000163625463703491	0.00229779414620172
GO:0030145	manganese ion binding	25/3355	68/18639	0.367647058823529	2.04249583589024	0.00018810120186142	0.00261340605990441
GO:0008171	O-methyltransferase activity	12/3355	23/18639	0.521739130434783	2.89856800362859	0.000212699911759655	0.00287406365166108
GO:0051117	ATPase binding	29/3355	84/18639	0.345238095238095	1.91800085160741	0.000215190651451321	0.00287406365166108
GO:0000993	RNA polymerase II complex binding	16/3355	36/18639	0.444444444444444	2.46915052160954	0.000220066129529945	0.00287406365166108
GO:0140838	RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity	16/3355	36/18639	0.444444444444444	2.46915052160954	0.000220066129529945	0.00287406365166108
GO:0140839	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	16/3355	36/18639	0.444444444444444	2.46915052160954	0.000220066129529945	0.00287406365166108
GO:0140840	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	16/3355	36/18639	0.444444444444444	2.46915052160954	0.000220066129529945	0.00287406365166108
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	15/3355	33/18639	0.454545454545455	2.52526757891885	0.000254688974692642	0.00329330495988704
GO:0005049	nuclear export signal receptor activity	8/3355	12/18639	0.666666666666667	3.70372578241431	0.000270851800924131	0.00343429565055257
GO:0016423	tRNA (guanine) methyltransferase activity	8/3355	12/18639	0.666666666666667	3.70372578241431	0.000270851800924131	0.00343429565055257
GO:0003954	NADH dehydrogenase activity	18/3355	44/18639	0.409090909090909	2.27274082102696	0.000322141344671159	0.00402282012012099
GO:0008320	protein transmembrane transporter activity	13/3355	27/18639	0.481481481481481	2.674913065077	0.000325755449910107	0.00402282012012099
GO:0003684	damaged DNA binding	26/3355	74/18639	0.351351351351351	1.95196358802916	0.000326507605461581	0.00402282012012099
GO:0055105	ubiquitin-protein transferase inhibitor activity	9/3355	15/18639	0.6	3.33335320417288	0.000343607003505656	0.00419393221101295
GO:0003746	translation elongation factor activity	10/3355	18/18639	0.555555555555556	3.08643815201192	0.000374760856977358	0.00453183036307805
GO:0008137	NADH dehydrogenase (ubiquinone) activity	17/3355	41/18639	0.414634146341463	2.30353676711134	0.000388328129177063	0.00461051397004768
GO:0061650	ubiquitin-like protein conjugating enzyme activity	17/3355	41/18639	0.414634146341463	2.30353676711134	0.000388328129177063	0.00461051397004768
GO:0140994	RNA polymerase II CTD heptapeptide repeat modifying activity	39/3355	128/18639	0.3046875	1.69271842399404	0.000400644843156353	0.00471389337983961
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	7/3355	10/18639	0.7	3.88891207153502	0.000438211246497444	0.00502020954320757
GO:0051880	G-quadruplex DNA binding	7/3355	10/18639	0.7	3.88891207153502	0.000438211246497444	0.00502020954320757
GO:0097177	mitochondrial ribosome binding	7/3355	10/18639	0.7	3.88891207153502	0.000438211246497444	0.00502020954320757
GO:0016859	cis-trans isomerase activity	17/3355	42/18639	0.404761904761905	2.24869065360869	0.000543934169267487	0.00617720021794207
GO:0140666	annealing activity	8/3355	13/18639	0.615384615384615	3.41882379915167	0.000592857122606815	0.00667475346659052
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	22/3355	61/18639	0.360655737704918	2.00365493147003	0.000608135387088494	0.00678824628664593
GO:0022853	active monoatomic ion transmembrane transporter activity	36/3355	118/18639	0.305084745762712	1.694925358054	0.000638479682363942	0.00706656326412973
GO:0022884	macromolecule transmembrane transporter activity	14/3355	32/18639	0.4375	2.43057004470939	0.00065771072895853	0.00717390612544179
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	16/3355	39/18639	0.41025641025641	2.27921586610111	0.000659164421939521	0.00717390612544179
GO:0035064	methylated histone binding	25/3355	74/18639	0.337837837837838	1.87688806541266	0.000820921976928669	0.00886052976751109
GO:0005048	signal sequence binding	19/3355	51/18639	0.372549019607843	2.06972911370211	0.000890590033385337	0.00953369330820697
GO:0140664	ATP-dependent DNA damage sensor activity	10/3355	20/18639	0.5	2.77779433681073	0.00111435028290881	0.0117913480959103
GO:0016407	acetyltransferase activity	30/3355	96/18639	0.3125	1.73612146050671	0.00113400189467513	0.0117913480959103
GO:0008187	poly-pyrimidine tract binding	13/3355	30/18639	0.433333333333333	2.4074217585693	0.00113760326193315	0.0117913480959103
GO:0035925	mRNA 3'-UTR AU-rich region binding	13/3355	30/18639	0.433333333333333	2.4074217585693	0.00113760326193315	0.0117913480959103
GO:0032977	membrane insertase activity	9/3355	17/18639	0.529411764705882	2.94119400368195	0.0011790697954497	0.0121249224634434
GO:0016651	oxidoreductase activity, acting on NAD(P)H	28/3355	88/18639	0.318181818181818	1.76768730524319	0.00120024140079623	0.012246213042499
GO:0016877	ligase activity, forming carbon-sulfur bonds	16/3355	41/18639	0.390243902439024	2.16803460434008	0.00125504305388557	0.0126083556028811
GO:0140318	protein transporter activity	16/3355	41/18639	0.390243902439024	2.16803460434008	0.00125504305388557	0.0126083556028811
GO:0140034	methylation-dependent protein binding	25/3355	76/18639	0.328947368421053	1.82749627421759	0.00126860494698435	0.012647313440928
GO:0008175	tRNA methyltransferase activity	14/3355	34/18639	0.411764705882353	2.28759533619707	0.00135667839122951	0.013422893779892
GO:0042162	telomeric DNA binding	15/3355	38/18639	0.394736842105263	2.1929955290611	0.00154212353094314	0.0151429573790356
GO:0004601	peroxidase activity	20/3355	57/18639	0.350877192982456	1.94932935916542	0.00156362371139275	0.0152394967692458
GO:0016866	intramolecular transferase activity	12/3355	28/18639	0.428571428571429	2.3809665744092	0.00196822044475371	0.0190407103766545
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	9/3355	18/18639	0.5	2.77779433681073	0.00198337873392204	0.0190462693125161
GO:0000340	RNA 7-methylguanosine cap binding	7/3355	12/18639	0.583333333333333	3.24076005961252	0.00206236707182716	0.0196602291664692
GO:0015399	primary active transmembrane transporter activity	45/3355	166/18639	0.271084337349398	1.50603307417449	0.00230840450889399	0.021714282499814
GO:0051059	NF-kappaB binding	13/3355	32/18639	0.40625	2.25695789865872	0.0023110913227214	0.021714282499814
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	20/3355	59/18639	0.338983050847458	1.88325039783778	0.00250724504046231	0.0233890144488842
GO:0004860	protein kinase inhibitor activity	26/3355	84/18639	0.30952380952381	1.71958697040664	0.00272089242569036	0.0252020248790895
GO:0019838	growth factor binding	38/3355	136/18639	0.279411764705882	1.55229683527658	0.00275141831357974	0.0253052980108108
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	15/3355	40/18639	0.375	2.08334575260805	0.00280026905489353	0.025574485214622
GO:0019205	nucleobase-containing compound kinase activity	16/3355	44/18639	0.363636363636364	2.02021406313508	0.00295484092933652	0.0267987656507882
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	58/3355	229/18639	0.253275109170306	1.40709232781679	0.00333563735139431	0.0300437405580757
GO:0034450	ubiquitin-ubiquitin ligase activity	8/3355	16/18639	0.5	2.77779433681073	0.0035481899815705	0.0314429520581202
GO:0043023	ribosomal large subunit binding	8/3355	16/18639	0.5	2.77779433681073	0.0035481899815705	0.0314429520581202
GO:0001094	TFIID-class transcription factor complex binding	6/3355	10/18639	0.6	3.33335320417288	0.00365951662544738	0.0314429520581202
GO:0016427	tRNA (cytidine) methyltransferase activity	6/3355	10/18639	0.6	3.33335320417288	0.00365951662544738	0.0314429520581202
GO:0031957	very long-chain fatty acid-CoA ligase activity	6/3355	10/18639	0.6	3.33335320417288	0.00365951662544738	0.0314429520581202
GO:0032356	oxidized DNA binding	6/3355	10/18639	0.6	3.33335320417288	0.00365951662544738	0.0314429520581202
GO:0047429	nucleoside triphosphate diphosphatase activity	6/3355	10/18639	0.6	3.33335320417288	0.00365951662544738	0.0314429520581202
GO:0019210	kinase inhibitor activity	27/3355	90/18639	0.3	1.66667660208644	0.00371713643334767	0.0317292822349808
GO:0009982	pseudouridine synthase activity	7/3355	13/18639	0.538461538461538	2.99147082425771	0.00377679534591757	0.0318225465920539
GO:0140852	histone ubiquitin ligase activity	7/3355	13/18639	0.538461538461538	2.99147082425771	0.00377679534591757	0.0318225465920539
GO:0060590	ATPase regulator activity	17/3355	49/18639	0.346938775510204	1.92744913166459	0.00391049943003278	0.0327378990745052
GO:0140297	DNA-binding transcription factor binding	111/3355	488/18639	0.227459016393443	1.26366873518849	0.00416974209846974	0.0346858801312196
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	13/3355	34/18639	0.382352941176471	2.12419566932585	0.00432938599597869	0.0357859374097985
GO:0003714	transcription corepressor activity	52/3355	204/18639	0.254901960784314	1.41613044621724	0.00456415716865153	0.0374892406431377
GO:0031072	heat shock protein binding	36/3355	131/18639	0.274809160305344	1.52672665839979	0.00469977197627456	0.0383618887563411
GO:0035198	miRNA binding	15/3355	42/18639	0.357142857142857	1.98413881200766	0.00480235507871088	0.0388890888499569
GO:0001671	ATPase activator activity	11/3355	27/18639	0.407407407407407	2.26338797814208	0.00482476309037342	0.0388890888499569
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	9/3355	20/18639	0.45	2.50001490312966	0.00485369179367762	0.0388890888499569
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	16/3355	46/18639	0.347826086956522	1.93237866908573	0.00490878203198169	0.0390555886430566
GO:0140463	chromatin-protein adaptor activity	18/3355	54/18639	0.333333333333333	1.85186289120715	0.00493428187297423	0.0390555886430566
GO:0016779	nucleotidyltransferase activity	37/3355	136/18639	0.272058823529412	1.51144691855878	0.00502648667402788	0.0395457325077133
GO:0016878	acid-thiol ligase activity	12/3355	31/18639	0.387096774193548	2.15055045430508	0.00537818218356188	0.0420593169564779
GO:0070402	NADPH binding	8/3355	17/18639	0.470588235294118	2.61439466993951	0.00565407459145565	0.0439536989073874
GO:0043015	gamma-tubulin binding	13/3355	35/18639	0.371428571428571	2.06350436448797	0.0057704494203434	0.0440713856313946
GO:0061631	ubiquitin conjugating enzyme activity	13/3355	35/18639	0.371428571428571	2.06350436448797	0.0057704494203434	0.0440713856313946
GO:0140566	histone reader activity	13/3355	35/18639	0.371428571428571	2.06350436448797	0.0057704494203434	0.0440713856313946
GO:0140612	DNA damage sensor activity	10/3355	24/18639	0.416666666666667	2.31482861400894	0.00589513864975654	0.0447619248638491
GO:0019001	guanyl nucleotide binding	92/3355	400/18639	0.23	1.27778539493294	0.0062188958101278	0.0466774593564765
GO:0032561	guanyl ribonucleotide binding	92/3355	400/18639	0.23	1.27778539493294	0.0062188958101278	0.0466774593564765
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	6/3355	11/18639	0.545454545454545	3.03032109470261	0.00683015677942377	0.0503965240334884
GO:0034511	U3 snoRNA binding	6/3355	11/18639	0.545454545454545	3.03032109470261	0.00683015677942377	0.0503965240334884
GO:0070990	snRNP binding	6/3355	11/18639	0.545454545454545	3.03032109470261	0.00683015677942377	0.0503965240334884
GO:0031369	translation initiation factor binding	12/3355	32/18639	0.375	2.08334575260805	0.00721843670006616	0.0526663593870749
GO:0070717	poly-purine tract binding	12/3355	32/18639	0.375	2.08334575260805	0.00721843670006616	0.0526663593870749
GO:0005525	GTP binding	87/3355	378/18639	0.23015873015873	1.27866723440494	0.00748538005549924	0.0543105908471223
GO:0004518	nuclease activity	52/3355	209/18639	0.248803827751196	1.38225172740821	0.00758315255753145	0.0547160068515805
GO:0004532	RNA exonuclease activity	14/3355	40/18639	0.35	1.94445603576751	0.00776302635799495	0.0556829480107353
GO:0016879	ligase activity, forming carbon-nitrogen bonds	16/3355	48/18639	0.333333333333333	1.85186289120715	0.00780243452217807	0.0556829480107353
GO:0008139	nuclear localization sequence binding	10/3355	25/18639	0.4	2.22223546944858	0.00826398297782761	0.0586563139621895
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	8/3355	18/18639	0.444444444444444	2.46915052160954	0.00859063127748255	0.0606452132345525
GO:0015932	nucleobase-containing compound transmembrane transporter activity	18/3355	57/18639	0.315789473684211	1.75439642324888	0.00920023561958566	0.0645995038665531
GO:0140296	general transcription initiation factor binding	17/3355	53/18639	0.320754716981132	1.78198127267103	0.00947207045239379	0.0660797504180273
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	35/3355	132/18639	0.265151515151515	1.47307275436933	0.00951224584884313	0.0660797504180273
GO:0008649	rRNA methyltransferase activity	9/3355	22/18639	0.409090909090909	2.27274082102696	0.0102025419585867	0.0697618837587129
GO:0034062	5'-3' RNA polymerase activity	9/3355	22/18639	0.409090909090909	2.27274082102696	0.0102025419585867	0.0697618837587129
GO:0097747	RNA polymerase activity	9/3355	22/18639	0.409090909090909	2.27274082102696	0.0102025419585867	0.0697618837587129
GO:0061980	regulatory RNA binding	18/3355	58/18639	0.310344827586207	1.72414820905494	0.011145585410521	0.0758132007611482
GO:0070006	metalloaminopeptidase activity	10/3355	26/18639	0.384615384615385	2.13676487446979	0.0113001624030348	0.0764663839293446
GO:0051287	NAD binding	17/3355	54/18639	0.314814814814815	1.74898161947342	0.0115570003402352	0.0764995864244877
GO:0000995	RNA polymerase III general transcription initiation factor activity	6/3355	12/18639	0.5	2.77779433681073	0.0115979464870203	0.0764995864244877
GO:0017166	vinculin binding	6/3355	12/18639	0.5	2.77779433681073	0.0115979464870203	0.0764995864244877
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	6/3355	12/18639	0.5	2.77779433681073	0.0115979464870203	0.0764995864244877
GO:1990247	N6-methyladenosine-containing RNA reader activity	6/3355	12/18639	0.5	2.77779433681073	0.0115979464870203	0.0764995864244877
GO:0051219	phosphoprotein binding	26/3355	93/18639	0.279569892473118	1.55317532810923	0.0117314560837282	0.0769913650520052
GO:0015605	organophosphate ester transmembrane transporter activity	16/3355	50/18639	0.32	1.77778837555887	0.0119204752503917	0.0778407033850576
GO:0015215	nucleotide transmembrane transporter activity	11/3355	30/18639	0.366666666666667	2.03704918032787	0.0119848066709658	0.0778714304093601
GO:0031492	nucleosomal DNA binding	14/3355	42/18639	0.333333333333333	1.85186289120715	0.0124099137030157	0.0802309572713495
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	13/3355	38/18639	0.342105263157895	1.90059612518629	0.0124708149510597	0.0802309572713495
GO:0004540	RNA nuclease activity	32/3355	121/18639	0.264462809917355	1.46924659137096	0.0132311908982683	0.0847055652604821
GO:0036002	pre-mRNA binding	18/3355	59/18639	0.305084745762712	1.694925358054	0.0134033138117532	0.0853889162836568
GO:0003887	DNA-directed DNA polymerase activity	9/3355	23/18639	0.391304347826087	2.17392600272144	0.0141318461301516	0.0883071341912821
GO:0017134	fibroblast growth factor binding	9/3355	23/18639	0.391304347826087	2.17392600272144	0.0141318461301516	0.0883071341912821
GO:0070577	lysine-acetylated histone binding	9/3355	23/18639	0.391304347826087	2.17392600272144	0.0141318461301516	0.0883071341912821
GO:0140102	catalytic activity, acting on a rRNA	9/3355	23/18639	0.391304347826087	2.17392600272144	0.0141318461301516	0.0883071341912821
GO:0019887	protein kinase regulator activity	60/3355	255/18639	0.235294117647059	1.30719733496976	0.0148797662617419	0.0922786700566609
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	32/3355	122/18639	0.262295081967213	1.45720358652366	0.0149180507573584	0.0922786700566609
GO:0008266	poly(U) RNA binding	10/3355	27/18639	0.37037037037037	2.05762543467461	0.0151092208222475	0.0922786700566609
GO:0016405	CoA-ligase activity	10/3355	27/18639	0.37037037037037	2.05762543467461	0.0151092208222475	0.0922786700566609
GO:0019842	vitamin binding	38/3355	150/18639	0.253333333333333	1.40741579731744	0.0151761797077928	0.0922786700566609
GO:0005324	long-chain fatty acid transmembrane transporter activity	7/3355	16/18639	0.4375	2.43057004470939	0.0152620158746085	0.0922786700566609
GO:0097027	ubiquitin-protein transferase activator activity	7/3355	16/18639	0.4375	2.43057004470939	0.0152620158746085	0.0922786700566609
GO:0016209	antioxidant activity	24/3355	86/18639	0.27906976744186	1.55039683915018	0.0153860945236247	0.0923949071217058
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	14/3355	43/18639	0.325581395348837	1.80879631234187	0.0154227333480336	0.0923949071217058
GO:0072349	modified amino acid transmembrane transporter activity	11/3355	31/18639	0.354838709677419	1.97133791644632	0.015618450139038	0.0931401638428473
GO:0000175	3'-5'-RNA exonuclease activity	12/3355	35/18639	0.342857142857143	1.90477325952736	0.0157819315490342	0.0932633601947453
GO:0034061	DNA polymerase activity	12/3355	35/18639	0.342857142857143	1.90477325952736	0.0157819315490342	0.0932633601947453
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	18/3355	60/18639	0.3	1.66667660208644	0.0160052650742205	0.0941570999411347
GO:0061608	nuclear import signal receptor activity	8/3355	20/18639	0.4	2.22223546944858	0.0176511887074747	0.103374226241982
GO:0019104	DNA N-glycosylase activity	6/3355	13/18639	0.461538461538462	2.56411784936375	0.0183017903222513	0.106231725159379
GO:0031994	insulin-like growth factor I binding	6/3355	13/18639	0.461538461538462	2.56411784936375	0.0183017903222513	0.106231725159379
GO:0001046	core promoter sequence-specific DNA binding	14/3355	44/18639	0.318181818181818	1.76768730524319	0.0189652590496972	0.109595700526126
GO:0140033	acetylation-dependent protein binding	9/3355	24/18639	0.375	2.08334575260805	0.0190738706183885	0.10973777545205
GO:0051537	2 iron, 2 sulfur cluster binding	10/3355	28/18639	0.357142857142857	1.98413881200766	0.0197959467157129	0.113392571976847
GO:0000182	rDNA binding	5/3355	10/18639	0.5	2.77779433681073	0.0212911152607985	0.118829899703431
GO:0016783	sulfurtransferase activity	5/3355	10/18639	0.5	2.77779433681073	0.0212911152607985	0.118829899703431
GO:0033204	ribonuclease P RNA binding	5/3355	10/18639	0.5	2.77779433681073	0.0212911152607985	0.118829899703431
GO:0098505	G-rich strand telomeric DNA binding	5/3355	10/18639	0.5	2.77779433681073	0.0212911152607985	0.118829899703431
GO:0140940	histone H2A methyltransferase activity	5/3355	10/18639	0.5	2.77779433681073	0.0212911152607985	0.118829899703431
GO:1990259	histone H2AQ104 methyltransferase activity	5/3355	10/18639	0.5	2.77779433681073	0.0212911152607985	0.118829899703431
GO:0004029	aldehyde dehydrogenase (NAD+) activity	7/3355	17/18639	0.411764705882353	2.28759533619707	0.0219875747728155	0.120149676373628
GO:0004550	nucleoside diphosphate kinase activity	7/3355	17/18639	0.411764705882353	2.28759533619707	0.0219875747728155	0.120149676373628
GO:0004659	prenyltransferase activity	7/3355	17/18639	0.411764705882353	2.28759533619707	0.0219875747728155	0.120149676373628
GO:0016018	cyclosporin A binding	7/3355	17/18639	0.411764705882353	2.28759533619707	0.0219875747728155	0.120149676373628
GO:0048038	quinone binding	7/3355	17/18639	0.411764705882353	2.28759533619707	0.0219875747728155	0.120149676373628
GO:0140030	modification-dependent protein binding	42/3355	173/18639	0.242774566473988	1.34875563174625	0.0226242545316184	0.12311365174289
GO:0046915	transition metal ion transmembrane transporter activity	14/3355	45/18639	0.311111111111111	1.72840536512668	0.0230899513106065	0.125126458139635
GO:0008408	3'-5' exonuclease activity	17/3355	58/18639	0.293103448275862	1.62836219744077	0.0237132461125266	0.127973138111404
GO:0019208	phosphatase regulator activity	30/3355	117/18639	0.256410256410256	1.42450991631319	0.024347250156253	0.130853945284224
GO:0015645	fatty acid ligase activity	9/3355	25/18639	0.36	2.00001192250373	0.025154432416204	0.133544180774691
GO:0120515	fatty acid-CoA ligase activity	9/3355	25/18639	0.36	2.00001192250373	0.025154432416204	0.133544180774691
GO:0016417	S-acyltransferase activity	10/3355	29/18639	0.344827586206897	1.91572023228326	0.0254613330879771	0.133544180774691
GO:0035250	UDP-galactosyltransferase activity	10/3355	29/18639	0.344827586206897	1.91572023228326	0.0254613330879771	0.133544180774691
GO:0051861	glycolipid binding	10/3355	29/18639	0.344827586206897	1.91572023228326	0.0254613330879771	0.133544180774691
GO:0106222	lncRNA binding	10/3355	29/18639	0.344827586206897	1.91572023228326	0.0254613330879771	0.133544180774691
GO:0004519	endonuclease activity	32/3355	127/18639	0.251968503937008	1.39983336658179	0.0261110180360301	0.136403958220221
GO:0008474	palmitoyl-(protein) hydrolase activity	6/3355	14/18639	0.428571428571429	2.3809665744092	0.0272368145459219	0.140044408649504
GO:0070742	C2H2 zinc finger domain binding	6/3355	14/18639	0.428571428571429	2.3809665744092	0.0272368145459219	0.140044408649504
GO:0098599	palmitoyl hydrolase activity	6/3355	14/18639	0.428571428571429	2.3809665744092	0.0272368145459219	0.140044408649504
GO:1990825	sequence-specific mRNA binding	6/3355	14/18639	0.428571428571429	2.3809665744092	0.0272368145459219	0.140044408649504
GO:0050660	flavin adenine dinucleotide binding	23/3355	86/18639	0.267441860465116	1.48579697085225	0.0283574674289357	0.145234715538
GO:0016829	lyase activity	47/3355	200/18639	0.235	1.30556333830104	0.0289344306264842	0.147610806242923
GO:0043531	ADP binding	12/3355	38/18639	0.315789473684211	1.75439642324888	0.0304006478298877	0.153860427034258
GO:0070628	proteasome binding	7/3355	18/18639	0.388888888888889	2.16050670640835	0.0305129024516637	0.153860427034258
GO:1901611	phosphatidylglycerol binding	7/3355	18/18639	0.388888888888889	2.16050670640835	0.0305129024516637	0.153860427034258
GO:0016831	carboxy-lyase activity	11/3355	34/18639	0.323529411764706	1.79739633558341	0.0314468558927749	0.157354765501778
GO:0030332	cyclin binding	11/3355	34/18639	0.323529411764706	1.79739633558341	0.0314468558927749	0.157354765501778
GO:0008143	poly(A) binding	9/3355	26/18639	0.346153846153846	1.92308838702281	0.0324890459525878	0.160680958220783
GO:0008080	N-acetyltransferase activity	19/3355	69/18639	0.27536231884058	1.52979977969287	0.0329355283920659	0.160680958220783
GO:0004523	RNA-DNA hybrid ribonuclease activity	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0005536	D-glucose binding	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0032404	mismatch repair complex binding	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0035252	UDP-xylosyltransferase activity	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0042285	xylosyltransferase activity	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0048407	platelet-derived growth factor binding	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:1990948	ubiquitin ligase inhibitor activity	5/3355	11/18639	0.454545454545455	2.52526757891885	0.0333419139952774	0.160680958220783
GO:0052689	carboxylic ester hydrolase activity	24/3355	92/18639	0.260869565217391	1.44928400181429	0.0337744113747203	0.162166842850679
GO:0019212	phosphatase inhibitor activity	16/3355	56/18639	0.285714285714286	1.58731104960613	0.0347751522975458	0.166360252383131
GO:0048029	monosaccharide binding	20/3355	74/18639	0.27027027027027	1.50151045233012	0.0351911572867159	0.167735954074638
GO:0019207	kinase regulator activity	64/3355	287/18639	0.222996515679443	1.23887691676576	0.0359460195678071	0.170710914747477
GO:0016776	phosphotransferase activity, phosphate group as acceptor	12/3355	39/18639	0.307692307692308	1.70941189957583	0.0369372949651112	0.174782997189983
GO:0016835	carbon-oxygen lyase activity	21/3355	79/18639	0.265822784810127	1.47680205248165	0.0372768995550657	0.175753179851682
GO:0016791	phosphatase activity	61/3355	273/18639	0.223443223443223	1.24135864135864	0.0383537635404627	0.180179910733253
GO:0004467	long-chain fatty acid-CoA ligase activity	6/3355	15/18639	0.4	2.22223546944858	0.0386365462122669	0.180211890547216
GO:0140776	protein-containing complex destabilizing activity	6/3355	15/18639	0.4	2.22223546944858	0.0386365462122669	0.180211890547216
GO:0004527	exonuclease activity	22/3355	84/18639	0.261904761904762	1.45503512880562	0.0392016601413245	0.182197039660391
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	76/3355	349/18639	0.217765042979943	1.20981300629006	0.0396104110773903	0.183443960521531
GO:0008327	methyl-CpG binding	10/3355	31/18639	0.32258064516129	1.79212537858757	0.0400953801809804	0.185033803944736
GO:0004721	phosphoprotein phosphatase activity	41/3355	175/18639	0.234285714285714	1.30159506067703	0.0408747873073663	0.185287739615404
GO:0005520	insulin-like growth factor binding	7/3355	19/18639	0.368421052631579	2.0467958271237	0.0410016514156599	0.185287739615404
GO:0008301	DNA binding, bending	7/3355	19/18639	0.368421052631579	2.0467958271237	0.0410016514156599	0.185287739615404
GO:0008574	plus-end-directed microtubule motor activity	7/3355	19/18639	0.368421052631579	2.0467958271237	0.0410016514156599	0.185287739615404
GO:0015245	fatty acid transmembrane transporter activity	7/3355	19/18639	0.368421052631579	2.0467958271237	0.0410016514156599	0.185287739615404
GO:0046527	glucosyltransferase activity	7/3355	19/18639	0.368421052631579	2.0467958271237	0.0410016514156599	0.185287739615404
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	9/3355	27/18639	0.333333333333333	1.85186289120715	0.0411789585177579	0.185447309738593
GO:0016790	thiolester hydrolase activity	13/3355	44/18639	0.295454545454545	1.64142392629725	0.0419151850196575	0.187469971355044
GO:0030020	extracellular matrix structural constituent conferring tensile strength	13/3355	44/18639	0.295454545454545	1.64142392629725	0.0419151850196575	0.187469971355044
GO:0140299	molecular sensor activity	19/3355	71/18639	0.267605633802817	1.48670682815222	0.04321545145976	0.192625868963981
GO:0034212	protein N-acetyltransferase activity	15/3355	53/18639	0.283018867924528	1.57233641706268	0.0433841913407029	0.192720251329789
GO:0004177	aminopeptidase activity	12/3355	40/18639	0.3	1.66667660208644	0.044405527277596	0.196588537710306
GO:0004526	ribonuclease P activity	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0016273	arginine N-methyltransferase activity	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0016274	protein-arginine N-methyltransferase activity	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0031543	peptidyl-proline dioxygenase activity	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0035251	UDP-glucosyltransferase activity	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0036009	protein-glutamine N-methyltransferase activity	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0043047	single-stranded telomeric DNA binding	5/3355	12/18639	0.416666666666667	2.31482861400894	0.048873319358318	0.21135283139723
GO:0008378	galactosyltransferase activity	10/3355	32/18639	0.3125	1.73612146050671	0.0492212542730173	0.212154977163566
GO:1901682	sulfur compound transmembrane transporter activity	17/3355	63/18639	0.26984126984127	1.49912710240579	0.0501409487898547	0.21540815499852
GO:0046625	sphingolipid binding	9/3355	28/18639	0.321428571428571	1.7857249308069	0.0513077535818846	0.219698118616201
GO:0005521	lamin binding	6/3355	16/18639	0.375	2.08334575260805	0.0526612644148618	0.222112861151142
GO:0022858	alanine transmembrane transporter activity	6/3355	16/18639	0.375	2.08334575260805	0.0526612644148618	0.222112861151142
GO:0004812	aminoacyl-tRNA ligase activity	12/3355	41/18639	0.292682926829268	1.62602595325506	0.0528550250933308	0.222112861151142
GO:0016875	ligase activity, forming carbon-oxygen bonds	12/3355	41/18639	0.292682926829268	1.62602595325506	0.0528550250933308	0.222112861151142
GO:0042169	SH2 domain binding	12/3355	41/18639	0.292682926829268	1.62602595325506	0.0528550250933308	0.222112861151142
GO:0001091	RNA polymerase II general transcription initiation factor binding	8/3355	24/18639	0.333333333333333	1.85186289120715	0.0528921131837712	0.222112861151142
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	21/3355	82/18639	0.25609756097561	1.42277270909818	0.053629965616312	0.224489535560588
GO:0032182	ubiquitin-like protein binding	29/3355	120/18639	0.241666666666667	1.34260059612519	0.0538256220704467	0.224588697840266
GO:0043539	protein serine/threonine kinase activator activity	19/3355	73/18639	0.26027397260274	1.44597513423024	0.055628383883992	0.231371558447432
GO:0030291	protein serine/threonine kinase inhibitor activity	13/3355	46/18639	0.282608695652174	1.57005766863215	0.0581172720125672	0.240956054756866
GO:0002039	p53 binding	18/3355	69/18639	0.260869565217391	1.44928400181429	0.0601209153167761	0.248474415834524
GO:0140789	histone phosphatase activity	32/3355	136/18639	0.235294117647059	1.30719733496976	0.0614011632057029	0.252780224975635
GO:0019888	protein phosphatase regulator activity	26/3355	107/18639	0.242990654205607	1.34995612630054	0.0615498556985083	0.252780224975635
GO:0004520	DNA endonuclease activity	12/3355	42/18639	0.285714285714286	1.58731104960613	0.0623269766586254	0.25516937779362
GO:0016830	carbon-carbon lyase activity	14/3355	51/18639	0.274509803921569	1.52506355746471	0.0627373037486625	0.256046620924229
GO:0004722	protein serine/threonine phosphatase activity	25/3355	103/18639	0.242718446601942	1.34844385282074	0.0664977876084729	0.269513539059784
GO:0061733	protein-lysine-acetyltransferase activity	13/3355	47/18639	0.276595744680851	1.53665218632083	0.0676105032763413	0.269513539059784
GO:0097110	scaffold protein binding	18/3355	70/18639	0.257142857142857	1.42857994464552	0.0678402206297644	0.269513539059784
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	5/3355	13/18639	0.384615384615385	2.13676487446979	0.0679805250058597	0.269513539059784
GO:0008253	5'-nucleotidase activity	5/3355	13/18639	0.384615384615385	2.13676487446979	0.0679805250058597	0.269513539059784
GO:0019855	calcium channel inhibitor activity	5/3355	13/18639	0.384615384615385	2.13676487446979	0.0679805250058597	0.269513539059784
GO:0030955	potassium ion binding	5/3355	13/18639	0.384615384615385	2.13676487446979	0.0679805250058597	0.269513539059784
GO:0043560	insulin receptor substrate binding	5/3355	13/18639	0.384615384615385	2.13676487446979	0.0679805250058597	0.269513539059784
GO:0051011	microtubule minus-end binding	5/3355	13/18639	0.384615384615385	2.13676487446979	0.0679805250058597	0.269513539059784
GO:0051010	microtubule plus-end binding	7/3355	21/18639	0.333333333333333	1.85186289120715	0.0683070301904965	0.269513539059784
GO:1904047	S-adenosyl-L-methionine binding	7/3355	21/18639	0.333333333333333	1.85186289120715	0.0683070301904965	0.269513539059784
GO:0004549	tRNA-specific ribonuclease activity	6/3355	17/18639	0.352941176470588	1.96079600245463	0.0693923678559781	0.272151448708431
GO:0051787	misfolded protein binding	6/3355	17/18639	0.352941176470588	1.96079600245463	0.0693923678559781	0.272151448708431
GO:0019825	oxygen binding	10/3355	34/18639	0.294117647058824	1.63399666871219	0.0713809003816668	0.278278972831215
GO:0090482	vitamin transmembrane transporter activity	10/3355	34/18639	0.294117647058824	1.63399666871219	0.0713809003816668	0.278278972831215
GO:0004712	protein serine/threonine/tyrosine kinase activity	12/3355	43/18639	0.27906976744186	1.55039683915018	0.072853086949453	0.283173010583291
GO:0003774	cytoskeletal motor activity	35/3355	153/18639	0.228758169934641	1.27088629788726	0.0737287079724061	0.285726090836684
GO:0043130	ubiquitin binding	24/3355	100/18639	0.24	1.33334128166915	0.0790772999772261	0.303737368053061
GO:0001618	virus receptor activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0033192	calmodulin-dependent protein phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0140791	histone H2AXS140 phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0180004	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0180005	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0180006	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0180007	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0180008	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:1990439	MAP kinase serine/threonine phosphatase activity	20/3355	81/18639	0.246913580246914	1.37175028978308	0.0807020418946493	0.303737368053061
GO:0017124	SH3 domain binding	27/3355	115/18639	0.234782608695652	1.30435560163286	0.0821377452686254	0.308252572760991
GO:0005528	FK506 binding	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0008190	eukaryotic initiation factor 4E binding	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0008641	ubiquitin-like modifier activating enzyme activity	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0016303	1-phosphatidylinositol-3-kinase activity	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0030957	Tat protein binding	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0031078	histone H3K14 deacetylase activity, hydrolytic mechanism	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0031996	thioesterase binding	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0034739	histone H4K16 deacetylase activity, hydrolytic mechanism	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0050815	phosphoserine residue binding	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0099122	RNA polymerase II C-terminal domain binding	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0180032	histone H4K5 deacetylase activity, hydrolytic mechanism	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0180033	histone H4K8 deacetylase activity, hydrolytic mechanism	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:1990162	histone H3K4 deacetylase activity, hydrolytic mechanism	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:1990757	ubiquitin ligase activator activity	4/3355	10/18639	0.4	2.22223546944858	0.0882843500040413	0.316756486552961
GO:0000900	mRNA regulatory element binding translation repressor activity	6/3355	18/18639	0.333333333333333	1.85186289120715	0.0888321005581355	0.316980118385041
GO:0098641	cadherin binding involved in cell-cell adhesion	6/3355	18/18639	0.333333333333333	1.85186289120715	0.0888321005581355	0.316980118385041
GO:0033549	MAP kinase phosphatase activity	20/3355	82/18639	0.24390243902439	1.35502162771255	0.089434969726371	0.317277188031656
GO:0140272	exogenous protein binding	20/3355	82/18639	0.24390243902439	1.35502162771255	0.089434969726371	0.317277188031656
GO:0008174	mRNA methyltransferase activity	5/3355	14/18639	0.357142857142857	1.98413881200766	0.0906159197058252	0.317277188031656
GO:0016530	metallochaperone activity	5/3355	14/18639	0.357142857142857	1.98413881200766	0.0906159197058252	0.317277188031656
GO:0019992	diacylglycerol binding	5/3355	14/18639	0.357142857142857	1.98413881200766	0.0906159197058252	0.317277188031656
GO:0052816	long-chain fatty acyl-CoA hydrolase activity	5/3355	14/18639	0.357142857142857	1.98413881200766	0.0906159197058252	0.317277188031656
GO:0098847	sequence-specific single stranded DNA binding	5/3355	14/18639	0.357142857142857	1.98413881200766	0.0906159197058252	0.317277188031656
GO:0061791	GTPase motor activity	11/3355	40/18639	0.275	1.5277868852459	0.0914008053502195	0.318318538099698
GO:1990606	membrane scission GTPase motor activity	11/3355	40/18639	0.275	1.5277868852459	0.0914008053502195	0.318318538099698
GO:0003777	microtubule motor activity	17/3355	68/18639	0.25	1.38889716840537	0.092484606073343	0.3195367606661
GO:0140223	general transcription initiation factor activity	17/3355	68/18639	0.25	1.38889716840537	0.092484606073343	0.3195367606661
GO:1990841	promoter-specific chromatin binding	17/3355	68/18639	0.25	1.38889716840537	0.092484606073343	0.3195367606661
GO:0050661	NADP binding	14/3355	54/18639	0.259259259259259	1.44033780427223	0.093774659673425	0.323139064732172
GO:0004521	RNA endonuclease activity	18/3355	73/18639	0.246575342465753	1.36987117979707	0.0949087033385675	0.326186227789919
GO:0005385	zinc ion transmembrane transporter activity	8/3355	27/18639	0.296296296296296	1.64610034773969	0.0975031693733078	0.334203062944447
GO:0019783	ubiquitin-like protein peptidase activity	29/3355	127/18639	0.228346456692913	1.26859898846474	0.0980535850008094	0.334203062944447
GO:0042826	histone deacetylase binding	29/3355	127/18639	0.228346456692913	1.26859898846474	0.0980535850008094	0.334203062944447
GO:0020037	heme binding	32/3355	142/18639	0.225352112676056	1.25196364475977	0.0987068455108533	0.334203062944447
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	20/3355	83/18639	0.240963855421687	1.33869606593288	0.0987588593562341	0.334203062944447
GO:0046906	tetrapyrrole binding	34/3355	152/18639	0.223684210526316	1.24269746646796	0.0987767092622944	0.334203062944447
GO:0003924	GTPase activity	69/3355	331/18639	0.208459214501511	1.15811365099662	0.100453135865502	0.338160162904763
GO:0004536	DNA nuclease activity	16/3355	64/18639	0.25	1.38889716840537	0.100464121904325	0.338160162904763
GO:0004857	enzyme inhibitor activity	85/3355	416/18639	0.204326923076923	1.13515633956208	0.108366380480553	0.36382131852854
GO:0017018	myosin phosphatase activity	20/3355	84/18639	0.238095238095238	1.32275920800511	0.108677543589653	0.363930440841247
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	15/3355	60/18639	0.25	1.38889716840537	0.109252931635167	0.364921556817209
GO:0050145	nucleoside monophosphate kinase activity	6/3355	19/18639	0.315789473684211	1.75439642324888	0.110907692470047	0.36902603665372
GO:0016410	N-acyltransferase activity	22/3355	94/18639	0.234042553191489	1.30024415765609	0.111046885455522	0.36902603665372
GO:0005506	iron ion binding	34/3355	154/18639	0.220779220779221	1.22655853833201	0.113418675380056	0.37595124377247
GO:0097718	disordered domain specific binding	8/3355	28/18639	0.285714285714286	1.58731104960613	0.115981335689877	0.379374068462806
GO:0000774	adenyl-nucleotide exchange factor activity	5/3355	15/18639	0.333333333333333	1.85186289120715	0.116605606452604	0.379374068462806
GO:0004129	cytochrome-c oxidase activity	5/3355	15/18639	0.333333333333333	1.85186289120715	0.116605606452604	0.379374068462806
GO:0008252	nucleotidase activity	5/3355	15/18639	0.333333333333333	1.85186289120715	0.116605606452604	0.379374068462806
GO:0010181	FMN binding	5/3355	15/18639	0.333333333333333	1.85186289120715	0.116605606452604	0.379374068462806
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	5/3355	15/18639	0.333333333333333	1.85186289120715	0.116605606452604	0.379374068462806
GO:0061578	K63-linked deubiquitinase activity	5/3355	15/18639	0.333333333333333	1.85186289120715	0.116605606452604	0.379374068462806
GO:0016757	glycosyltransferase activity	56/3355	267/18639	0.209737827715356	1.1652171000854	0.117482419089162	0.379374068462806
GO:0000099	sulfur amino acid transmembrane transporter activity	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0008526	phosphatidylinositol transfer activity	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0015173	aromatic amino acid transmembrane transporter activity	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0032129	histone H3K9 deacetylase activity, hydrolytic mechanism	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0047676	arachidonate-CoA ligase activity	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0048185	activin binding	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0140937	histone H4K12 deacetylase activity, hydrolytic mechanism	4/3355	11/18639	0.363636363636364	2.02021406313508	0.119680027723335	0.379374068462806
GO:0008276	protein methyltransferase activity	22/3355	95/18639	0.231578947368421	1.28655737704918	0.121082799798476	0.382891371759829
GO:0001221	transcription coregulator binding	26/3355	115/18639	0.226086956521739	1.25604613490572	0.122754974677327	0.387241538474854
GO:0050699	WW domain binding	7/3355	24/18639	0.291666666666667	1.62038002980626	0.125467406948374	0.394844418011027
GO:0015179	L-amino acid transmembrane transporter activity	15/3355	62/18639	0.241935483870968	1.34409403394068	0.135444842526372	0.421274728522363
GO:0015095	magnesium ion transmembrane transporter activity	6/3355	20/18639	0.3	1.66667660208644	0.135478856033226	0.421274728522363
GO:0016408	C-acyltransferase activity	6/3355	20/18639	0.3	1.66667660208644	0.135478856033226	0.421274728522363
GO:0030742	GTP-dependent protein binding	6/3355	20/18639	0.3	1.66667660208644	0.135478856033226	0.421274728522363
GO:0031418	L-ascorbic acid binding	6/3355	20/18639	0.3	1.66667660208644	0.135478856033226	0.421274728522363
GO:0004674	protein serine/threonine kinase activity	87/3355	433/18639	0.200923787528868	1.11624991825651	0.139714306955525	0.433413028227828
GO:0004864	protein phosphatase inhibitor activity	13/3355	53/18639	0.245283018867925	1.36269156145432	0.145042310169394	0.444501422218473
GO:1901505	carbohydrate derivative transmembrane transporter activity	13/3355	53/18639	0.245283018867925	1.36269156145432	0.145042310169394	0.444501422218473
GO:0004708	MAP kinase kinase activity	5/3355	16/18639	0.3125	1.73612146050671	0.14567121646976	0.444501422218473
GO:0008142	oxysterol binding	5/3355	16/18639	0.3125	1.73612146050671	0.14567121646976	0.444501422218473
GO:0015562	efflux transmembrane transporter activity	5/3355	16/18639	0.3125	1.73612146050671	0.14567121646976	0.444501422218473
GO:0016675	oxidoreductase activity, acting on a heme group of donors	5/3355	16/18639	0.3125	1.73612146050671	0.14567121646976	0.444501422218473
GO:0140328	floppase activity	5/3355	16/18639	0.3125	1.73612146050671	0.14567121646976	0.444501422218473
GO:0000030	mannosyltransferase activity	7/3355	25/18639	0.28	1.55556482861401	0.148614955428779	0.450327451948921
GO:0019211	phosphatase activator activity	7/3355	25/18639	0.28	1.55556482861401	0.148614955428779	0.450327451948921
GO:0047617	fatty acyl-CoA hydrolase activity	7/3355	25/18639	0.28	1.55556482861401	0.148614955428779	0.450327451948921
GO:0005507	copper ion binding	15/3355	63/18639	0.238095238095238	1.32275920800511	0.149752868611804	0.452725107423648
GO:0031490	chromatin DNA binding	28/3355	128/18639	0.21875	1.21528502235469	0.15168608405503	0.457510452138267
GO:0003995	acyl-CoA dehydrogenase activity	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0005095	GTPase inhibitor activity	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0005527	macrolide binding	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0035197	siRNA binding	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0035259	nuclear glucocorticoid receptor binding	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0141221	histone deacetylase activity, hydrolytic mechanism	4/3355	12/18639	0.333333333333333	1.85186289120715	0.155083381905844	0.460315674475072
GO:0016769	transferase activity, transferring nitrogenous groups	8/3355	30/18639	0.266666666666667	1.48149031296572	0.158033732548812	0.468009194350903
GO:0015078	proton transmembrane transporter activity	39/3355	185/18639	0.210810810810811	1.1711781528175	0.158477044150355	0.468260225475935
GO:0019903	protein phosphatase binding	31/3355	144/18639	0.215277777777778	1.19599478390462	0.159083799967632	0.468991970107738
GO:0003925	G protein activity	13/3355	54/18639	0.240740740740741	1.3374565325385	0.161297906668115	0.473272204909897
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	6/3355	21/18639	0.285714285714286	1.58731104960613	0.162347586370317	0.473272204909897
GO:0019200	carbohydrate kinase activity	6/3355	21/18639	0.285714285714286	1.58731104960613	0.162347586370317	0.473272204909897
GO:0035613	RNA stem-loop binding	6/3355	21/18639	0.285714285714286	1.58731104960613	0.162347586370317	0.473272204909897
GO:0072542	protein phosphatase activator activity	6/3355	21/18639	0.285714285714286	1.58731104960613	0.162347586370317	0.473272204909897
GO:0016758	hexosyltransferase activity	41/3355	197/18639	0.208121827411168	1.15623926709888	0.173003524129581	0.501579312617995
GO:0008198	ferrous iron binding	7/3355	26/18639	0.269230769230769	1.49573541212885	0.173594065316488	0.501579312617995
GO:0015216	purine nucleotide transmembrane transporter activity	7/3355	26/18639	0.269230769230769	1.49573541212885	0.173594065316488	0.501579312617995
GO:0016289	acyl-CoA hydrolase activity	7/3355	26/18639	0.269230769230769	1.49573541212885	0.173594065316488	0.501579312617995
GO:0005092	GDP-dissociation inhibitor activity	5/3355	17/18639	0.294117647058824	1.63399666871219	0.177454070058836	0.509351682410636
GO:0032183	SUMO binding	5/3355	17/18639	0.294117647058824	1.63399666871219	0.177454070058836	0.509351682410636
GO:0046965	nuclear retinoid X receptor binding	5/3355	17/18639	0.294117647058824	1.63399666871219	0.177454070058836	0.509351682410636
GO:0140313	molecular sequestering activity	13/3355	55/18639	0.236363636363636	1.3131391410378	0.178439660900561	0.511057449859942
GO:0160215	deacylase activity	15/3355	65/18639	0.230769230769231	1.28205892468188	0.180681675630531	0.516346320292065
GO:0002020	protease binding	29/3355	136/18639	0.213235294117647	1.18464758481634	0.182604850404734	0.520702914036207
GO:0022804	active transmembrane transporter activity	90/3355	457/18639	0.196936542669584	1.09409842587731	0.185324206204739	0.52730591133636
GO:0015175	neutral L-amino acid transmembrane transporter activity	10/3355	41/18639	0.24390243902439	1.35502162771255	0.190777126378401	0.540687675690221
GO:0061133	endopeptidase activator activity	6/3355	22/18639	0.272727272727273	1.51516054735131	0.191269300282452	0.540687675690221
GO:0140035	ubiquitin-like protein reader activity	6/3355	22/18639	0.272727272727273	1.51516054735131	0.191269300282452	0.540687675690221
GO:0002161	aminoacyl-tRNA editing activity	4/3355	13/18639	0.307692307692308	1.70941189957583	0.193795762750281	0.540806124256126
GO:0003964	RNA-directed DNA polymerase activity	4/3355	13/18639	0.307692307692308	1.70941189957583	0.193795762750281	0.540806124256126
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	4/3355	13/18639	0.307692307692308	1.70941189957583	0.193795762750281	0.540806124256126
GO:0005338	nucleotide-sugar transmembrane transporter activity	4/3355	13/18639	0.307692307692308	1.70941189957583	0.193795762750281	0.540806124256126
GO:0005542	folic acid binding	4/3355	13/18639	0.307692307692308	1.70941189957583	0.193795762750281	0.540806124256126
GO:0061459	L-arginine transmembrane transporter activity	4/3355	13/18639	0.307692307692308	1.70941189957583	0.193795762750281	0.540806124256126
GO:0051020	GTPase binding	63/3355	315/18639	0.2	1.11111773472429	0.194318663152783	0.541109113171717
GO:0030544	Hsp70 protein binding	12/3355	51/18639	0.235294117647059	1.30719733496976	0.195283706097479	0.542639404602783
GO:0015101	organic cation transmembrane transporter activity	18/3355	81/18639	0.222222222222222	1.23457526080477	0.196116280653313	0.543490382506724
GO:0030170	pyridoxal phosphate binding	13/3355	56/18639	0.232142857142857	1.28969022780498	0.196422251564452	0.543490382506724
GO:0004364	glutathione transferase activity	7/3355	27/18639	0.259259259259259	1.44033780427223	0.200225878896601	0.552843547228248
GO:0008525	phosphatidylcholine transporter activity	5/3355	18/18639	0.277777777777778	1.54321907600596	0.21153944294372	0.580400236311972
GO:0017128	phospholipid scramblase activity	5/3355	18/18639	0.277777777777778	1.54321907600596	0.21153944294372	0.580400236311972
GO:0070064	proline-rich region binding	5/3355	18/18639	0.277777777777778	1.54321907600596	0.21153944294372	0.580400236311972
GO:0004402	histone acetyltransferase activity	10/3355	42/18639	0.238095238095238	1.32275920800511	0.212624392712171	0.580936102263797
GO:0051879	Hsp90 protein binding	10/3355	42/18639	0.238095238095238	1.32275920800511	0.212624392712171	0.580936102263797
GO:0070279	vitamin B6 binding	13/3355	57/18639	0.228070175438596	1.26706408345753	0.2151931580152	0.586727065486118
GO:0008170	N-methyltransferase activity	21/3355	98/18639	0.214285714285714	1.1904832872046	0.221801435861689	0.601422440192315
GO:0000295	adenine nucleotide transmembrane transporter activity	6/3355	23/18639	0.260869565217391	1.44928400181429	0.2219644840526	0.601422440192315
GO:0004602	glutathione peroxidase activity	6/3355	23/18639	0.260869565217391	1.44928400181429	0.2219644840526	0.601422440192315
GO:0005548	phospholipid transporter activity	15/3355	68/18639	0.220588235294118	1.22549750153415	0.23234852724992	0.624170948316616
GO:0042887	amide transmembrane transporter activity	9/3355	38/18639	0.236842105263158	1.31579731743666	0.234348759749194	0.624170948316616
GO:0004705	JUN kinase activity	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:0005347	ATP transmembrane transporter activity	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:0030983	mismatched DNA binding	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:0044548	S100 protein binding	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:1901474	azole transmembrane transporter activity	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:1901612	cardiolipin binding	4/3355	14/18639	0.285714285714286	1.58731104960613	0.235067699968064	0.624170948316616
GO:0016251	RNA polymerase II general transcription initiation factor activity	12/3355	53/18639	0.226415094339623	1.25786913365014	0.235418175118613	0.624170948316616
GO:0140693	molecular condensate scaffold activity	11/3355	48/18639	0.229166666666667	1.27315573770492	0.235712969598517	0.624170948316616
GO:0042578	phosphoric ester hydrolase activity	71/3355	363/18639	0.195592286501377	1.08663029153478	0.236095289792043	0.624170948316616
GO:0101005	deubiquitinase activity	24/3355	115/18639	0.208695652173913	1.15942720145144	0.243392895497814	0.642163881858878
GO:0005346	purine ribonucleotide transmembrane transporter activity	5/3355	19/18639	0.263157894736842	1.46199701937407	0.247479353827175	0.647711495186955
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5/3355	19/18639	0.263157894736842	1.46199701937407	0.247479353827175	0.647711495186955
GO:0031420	alkali metal ion binding	5/3355	19/18639	0.263157894736842	1.46199701937407	0.247479353827175	0.647711495186955
GO:0097001	ceramide binding	5/3355	19/18639	0.263157894736842	1.46199701937407	0.247479353827175	0.647711495186955
GO:0008514	organic anion transmembrane transporter activity	53/3355	269/18639	0.197026022304833	1.09459553792542	0.25407423214591	0.656904229523704
GO:0005540	hyaluronic acid binding	6/3355	24/18639	0.25	1.38889716840537	0.254130176420676	0.656904229523704
GO:0050431	transforming growth factor beta binding	6/3355	24/18639	0.25	1.38889716840537	0.254130176420676	0.656904229523704
GO:0060229	lipase activator activity	6/3355	24/18639	0.25	1.38889716840537	0.254130176420676	0.656904229523704
GO:0070840	dynein complex binding	6/3355	24/18639	0.25	1.38889716840537	0.254130176420676	0.656904229523704
GO:0045309	protein phosphorylated amino acid binding	13/3355	59/18639	0.220338983050847	1.22411275859456	0.254858377446005	0.656904229523704
GO:0001222	transcription corepressor binding	11/3355	49/18639	0.224489795918367	1.24717296754767	0.25804088645529	0.656904229523704
GO:0016763	pentosyltransferase activity	11/3355	49/18639	0.224489795918367	1.24717296754767	0.25804088645529	0.656904229523704
GO:0016922	nuclear receptor binding	28/3355	137/18639	0.204379562043796	1.13544878001023	0.258543104451834	0.656904229523704
GO:0043014	alpha-tubulin binding	10/3355	44/18639	0.227272727272727	1.26263378945942	0.259081587965426	0.656904229523704
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	8/3355	34/18639	0.235294117647059	1.30719733496976	0.259197817062013	0.656904229523704
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	9/3355	39/18639	0.230769230769231	1.28205892468188	0.259551436120508	0.656904229523704
GO:0019787	ubiquitin-like protein transferase activity	92/3355	479/18639	0.192066805845511	1.06704417113398	0.259967046033552	0.656904229523704
GO:0001164	RNA polymerase I core promoter sequence-specific DNA binding	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0003680	minor groove of adenine-thymine-rich DNA binding	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0004090	carbonyl reductase (NADPH) activity	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0005337	nucleoside transmembrane transporter activity	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0005522	profilin binding	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0015658	branched-chain amino acid transmembrane transporter activity	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0015924	mannosyl-oligosaccharide mannosidase activity	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0016868	intramolecular phosphotransferase activity	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0031434	mitogen-activated protein kinase kinase binding	3/3355	10/18639	0.3	1.66667660208644	0.262768264154615	0.656904229523704
GO:0106310	protein serine kinase activity	70/3355	361/18639	0.193905817174515	1.07726096164405	0.263063485483076	0.656904229523704
GO:0016782	transferase activity, transferring sulphur-containing groups	15/3355	70/18639	0.214285714285714	1.1904832872046	0.269796556194223	0.672431874789419
GO:0005200	structural constituent of cytoskeleton	23/3355	112/18639	0.205357142857143	1.14087981690441	0.276111476693269	0.681533098118021
GO:0004559	alpha-mannosidase activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0004698	calcium,diacylglycerol-dependent serine/threonine kinase activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0004699	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0005041	low-density lipoprotein particle receptor activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0015556	C4-dicarboxylate transmembrane transporter activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0016846	carbon-sulfur lyase activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0141050	histone H3K deacetylase activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0141051	histone H4K deacetylase activity	4/3355	15/18639	0.266666666666667	1.48149031296572	0.278144824882776	0.681533098118021
GO:0140303	intramembrane lipid transporter activity	10/3355	45/18639	0.222222222222222	1.23457526080477	0.283467723001973	0.688702993781062
GO:0016004	phospholipase activator activity	5/3355	20/18639	0.25	1.38889716840537	0.284812853091825	0.688702993781062
GO:0140939	histone H4 methyltransferase activity	5/3355	20/18639	0.25	1.38889716840537	0.284812853091825	0.688702993781062
GO:0050997	quaternary ammonium group binding	9/3355	40/18639	0.225	1.25000745156483	0.28555425157204	0.688702993781062
GO:0010485	histone H4 acetyltransferase activity	8/3355	35/18639	0.228571428571429	1.26984883968491	0.287133903572257	0.688702993781062
GO:0015662	P-type ion transporter activity	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0017025	TBP-class protein binding	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0019706	protein-cysteine S-palmitoyltransferase activity	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0019707	protein-cysteine S-acyltransferase activity	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0042974	nuclear retinoic acid receptor binding	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0140358	P-type transmembrane transporter activity	6/3355	25/18639	0.24	1.33334128166915	0.28745077252338	0.688702993781062
GO:0001968	fibronectin binding	7/3355	30/18639	0.233333333333333	1.29630402384501	0.287926366465896	0.688702993781062
GO:0008234	cysteine-type peptidase activity	37/3355	187/18639	0.197860962566845	1.0992341225882	0.288665626726887	0.68920897350149
GO:0043178	alcohol binding	19/3355	92/18639	0.206521739130435	1.14734983476965	0.291757406807779	0.695319659290072
GO:0008235	metalloexopeptidase activity	14/3355	66/18639	0.212121212121212	1.17845820349546	0.29306263985034	0.697158119571118
GO:0035591	signaling adaptor activity	26/3355	129/18639	0.201550387596899	1.11973105049735	0.294014628823445	0.698151100442581
GO:0004843	cysteine-type deubiquitinase activity	22/3355	108/18639	0.203703703703704	1.13169398907104	0.295758644055323	0.701017766127499
GO:0016836	hydro-lyase activity	13/3355	61/18639	0.213114754098361	1.18397791405048	0.296901127791571	0.702450856695275
GO:0051213	dioxygenase activity	19/3355	93/18639	0.204301075268817	1.13501273977213	0.309218229373873	0.730011631693146
GO:0001163	RNA polymerase I transcription regulatory region sequence-specific DNA binding	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0002162	dystroglycan binding	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0005225	volume-sensitive anion channel activity	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0010854	adenylate cyclase regulator activity	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0015217	ADP transmembrane transporter activity	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0019107	myristoyltransferase activity	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0019206	nucleoside kinase activity	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0032794	GTPase activating protein binding	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0050786	RAGE receptor binding	3/3355	11/18639	0.272727272727273	1.51516054735131	0.316426352816345	0.730011631693146
GO:0044325	transmembrane transporter binding	27/3355	136/18639	0.198529411764706	1.10294775138073	0.318801734418894	0.730011631693146
GO:0004529	DNA exonuclease activity	6/3355	26/18639	0.230769230769231	1.28205892468188	0.321607784685448	0.730011631693146
GO:0030507	spectrin binding	6/3355	26/18639	0.230769230769231	1.28205892468188	0.321607784685448	0.730011631693146
GO:0050681	nuclear androgen receptor binding	6/3355	26/18639	0.230769230769231	1.28205892468188	0.321607784685448	0.730011631693146
GO:0050750	low-density lipoprotein particle receptor binding	6/3355	26/18639	0.230769230769231	1.28205892468188	0.321607784685448	0.730011631693146
GO:0120014	phospholipid transfer activity	6/3355	26/18639	0.230769230769231	1.28205892468188	0.321607784685448	0.730011631693146
GO:0004697	diacylglycerol-dependent serine/threonine kinase activity	4/3355	16/18639	0.25	1.38889716840537	0.322302694353782	0.730011631693146
GO:0004707	MAP kinase activity	4/3355	16/18639	0.25	1.38889716840537	0.322302694353782	0.730011631693146
GO:0005024	transforming growth factor beta receptor activity	4/3355	16/18639	0.25	1.38889716840537	0.322302694353782	0.730011631693146
GO:0008296	3'-5'-DNA exonuclease activity	4/3355	16/18639	0.25	1.38889716840537	0.322302694353782	0.730011631693146
GO:0015923	mannosidase activity	4/3355	16/18639	0.25	1.38889716840537	0.322302694353782	0.730011631693146
GO:0019841	retinol binding	4/3355	16/18639	0.25	1.38889716840537	0.322302694353782	0.730011631693146
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	5/3355	21/18639	0.238095238095238	1.32275920800511	0.323083248942296	0.730011631693146
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5/3355	21/18639	0.238095238095238	1.32275920800511	0.323083248942296	0.730011631693146
GO:0015174	basic amino acid transmembrane transporter activity	5/3355	21/18639	0.238095238095238	1.32275920800511	0.323083248942296	0.730011631693146
GO:0031267	small GTPase binding	54/3355	283/18639	0.190812720848057	1.06007699072636	0.339940046336745	0.766773230597217
GO:0022829	wide pore channel activity	8/3355	37/18639	0.216216216216216	1.2012083618641	0.344925784700718	0.776677715205409
GO:0016755	aminoacyltransferase activity	93/3355	496/18639	0.1875	1.04167287630402	0.347655956357776	0.780963361876773
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	35/3355	181/18639	0.193370165745856	1.07428510263398	0.348025020376939	0.780963361876773
GO:0042910	xenobiotic transmembrane transporter activity	7/3355	32/18639	0.21875	1.21528502235469	0.35058988459529	0.785369449882417
GO:0033218	amide binding	47/3355	247/18639	0.190283400809717	1.05713630631663	0.36116141504964	0.7991583307678
GO:0004407	histone deacetylase activity	5/3355	22/18639	0.227272727272727	1.26263378945942	0.361852057371662	0.7991583307678
GO:0030021	extracellular matrix structural constituent conferring compression resistance	5/3355	22/18639	0.227272727272727	1.26263378945942	0.361852057371662	0.7991583307678
GO:0033558	protein lysine deacetylase activity	5/3355	22/18639	0.227272727272727	1.26263378945942	0.361852057371662	0.7991583307678
GO:0004842	ubiquitin-protein transferase activity	84/3355	449/18639	0.187082405345212	1.03935289216972	0.365251922389711	0.7991583307678
GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	4/3355	17/18639	0.235294117647059	1.30719733496976	0.36687150182915	0.7991583307678
GO:0017110	nucleoside diphosphate phosphatase activity	4/3355	17/18639	0.235294117647059	1.30719733496976	0.36687150182915	0.7991583307678
GO:0038191	neuropilin binding	4/3355	17/18639	0.235294117647059	1.30719733496976	0.36687150182915	0.7991583307678
GO:1990226	histone methyltransferase binding	4/3355	17/18639	0.235294117647059	1.30719733496976	0.36687150182915	0.7991583307678
GO:0048156	tau protein binding	9/3355	43/18639	0.209302325581395	1.16279762936263	0.366884027344606	0.7991583307678
GO:0046943	carboxylic acid transmembrane transporter activity	36/3355	188/18639	0.191489361702128	1.06383612899134	0.368975638881838	0.7991583307678
GO:0003720	telomerase activity	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0005025	transforming growth factor beta receptor activity, type I	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0005026	transforming growth factor beta receptor activity, type II	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0016208	AMP binding	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0016361	activin receptor activity, type I	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0016362	activin receptor activity, type II	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0016801	hydrolase activity, acting on ether bonds	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0016803	ether hydrolase activity	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0016840	carbon-nitrogen lyase activity	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0017002	activin receptor activity	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0034452	dynactin binding	3/3355	12/18639	0.25	1.38889716840537	0.370207343119846	0.7991583307678
GO:0008194	UDP-glycosyltransferase activity	28/3355	145/18639	0.193103448275862	1.07280333007863	0.372832121306957	0.803496287833146
GO:0015485	cholesterol binding	11/3355	54/18639	0.203703703703704	1.13169398907104	0.377814181163155	0.811957125048582
GO:0008028	monocarboxylic acid transmembrane transporter activity	14/3355	70/18639	0.2	1.11111773472429	0.378001479348804	0.811957125048582
GO:0005342	organic acid transmembrane transporter activity	36/3355	189/18639	0.19047619047619	1.05820736640409	0.382138828027447	0.818879959813916
GO:0140416	transcription regulator inhibitor activity	7/3355	33/18639	0.212121212121212	1.17845820349546	0.382478388580773	0.818879959813916
GO:0015297	antiporter activity	26/3355	135/18639	0.192592592592593	1.0699652260308	0.385294203932733	0.823558478455235
GO:0008237	metallopeptidase activity	35/3355	184/18639	0.190217391304348	1.05676958465626	0.387907142333944	0.827788771059037
GO:0019902	phosphatase binding	36/3355	190/18639	0.189473684210526	1.05263785394933	0.395387534122495	0.842375398962445
GO:0042626	ATPase-coupled transmembrane transporter activity	19/3355	98/18639	0.193877551020408	1.07710392651845	0.400128421371809	0.846807265234313
GO:0005283	amino acid:sodium symporter activity	5/3355	23/18639	0.217391304347826	1.20773666817858	0.400709716626957	0.846807265234313
GO:0042171	lysophosphatidic acid acyltransferase activity	5/3355	23/18639	0.217391304347826	1.20773666817858	0.400709716626957	0.846807265234313
GO:0043274	phospholipase binding	5/3355	23/18639	0.217391304347826	1.20773666817858	0.400709716626957	0.846807265234313
GO:0071617	lysophospholipid acyltransferase activity	5/3355	23/18639	0.217391304347826	1.20773666817858	0.400709716626957	0.846807265234313
GO:0098632	cell-cell adhesion mediator activity	11/3355	55/18639	0.2	1.11111773472429	0.402666152172736	0.849567035117276
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0008308	voltage-gated monoatomic anion channel activity	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0015172	acidic amino acid transmembrane transporter activity	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0016854	racemase and epimerase activity	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0030228	lipoprotein particle receptor activity	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:1990381	ubiquitin-specific protease binding	4/3355	18/18639	0.222222222222222	1.23457526080477	0.41125209008213	0.856611211558631
GO:0019905	syntaxin binding	12/3355	61/18639	0.19672131147541	1.09290268989275	0.417651797343106	0.867517813662973
GO:0008035	high-density lipoprotein particle binding	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0035673	oligopeptide transmembrane transporter activity	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0045159	myosin II binding	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0070123	transforming growth factor beta receptor activity, type III	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0097157	pre-mRNA intronic binding	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0140333	glycerophospholipid flippase activity	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0140410	monoatomic cation:bicarbonate symporter activity	3/3355	13/18639	0.230769230769231	1.28205892468188	0.423130817230715	0.867517813662973
GO:0035402	histone H3T11 kinase activity	46/3355	247/18639	0.186234817813765	1.03464404448011	0.424583632485883	0.867771868586171
GO:0035403	histone H3T6 kinase activity	46/3355	247/18639	0.186234817813765	1.03464404448011	0.424583632485883	0.867771868586171
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	6/3355	29/18639	0.206896551724138	1.14943213936996	0.426037647479733	0.868026782540611
GO:0097472	cyclin-dependent protein kinase activity	6/3355	29/18639	0.206896551724138	1.14943213936996	0.426037647479733	0.868026782540611
GO:0042054	histone methyltransferase activity	13/3355	67/18639	0.194029850746269	1.07795004115043	0.431202101879074	0.877180599772696
GO:0030331	nuclear estrogen receptor binding	8/3355	40/18639	0.2	1.11111773472429	0.43367979089166	0.879481066621906
GO:0071949	FAD binding	8/3355	40/18639	0.2	1.11111773472429	0.43367979089166	0.879481066621906
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	17/3355	89/18639	0.191011235955056	1.06117985900635	0.435850852813736	0.881147389744179
GO:0030946	protein tyrosine phosphatase activity, metal-dependent	17/3355	89/18639	0.191011235955056	1.06117985900635	0.435850852813736	0.881147389744179
GO:0005315	phosphate transmembrane transporter activity	5/3355	24/18639	0.208333333333333	1.15741430700447	0.439283279839136	0.885345622638753
GO:0070300	phosphatidic acid binding	5/3355	24/18639	0.208333333333333	1.15741430700447	0.439283279839136	0.885345622638753
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	45/3355	243/18639	0.185185185185185	1.02881271733731	0.442382603867983	0.890218306088729
GO:0016229	steroid dehydrogenase activity	7/3355	35/18639	0.2	1.11111773472429	0.446266546899166	0.893134988889154
GO:0000149	SNARE binding	20/3355	106/18639	0.188679245283019	1.04822427804178	0.447104047593914	0.893134988889154
GO:0005178	integrin binding	30/3355	161/18639	0.186335403726708	1.03520285843878	0.448869420373305	0.893134988889154
GO:0016504	peptidase activator activity	11/3355	57/18639	0.192982456140351	1.07213114754098	0.452442422423766	0.893134988889154
GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	4/3355	19/18639	0.210526315789474	1.16959761549925	0.454924819750118	0.893134988889154
GO:0016918	retinal binding	4/3355	19/18639	0.210526315789474	1.16959761549925	0.454924819750118	0.893134988889154
GO:0046624	sphingolipid transporter activity	4/3355	19/18639	0.210526315789474	1.16959761549925	0.454924819750118	0.893134988889154
GO:0140036	ubiquitin-modified protein reader activity	4/3355	19/18639	0.210526315789474	1.16959761549925	0.454924819750118	0.893134988889154
GO:0140793	histone H2AXY142 phosphatase activity	17/3355	90/18639	0.188888888888889	1.04938897168405	0.455613133862834	0.893134988889154
GO:0035173	histone kinase activity	66/3355	360/18639	0.183333333333333	1.01852459016393	0.455774443680959	0.893134988889154
GO:0031210	phosphatidylcholine binding	6/3355	30/18639	0.2	1.11111773472429	0.460565467733193	0.893134988889154
GO:0051721	protein phosphatase 2A binding	6/3355	30/18639	0.2	1.11111773472429	0.460565467733193	0.893134988889154
GO:0070566	adenylyltransferase activity	6/3355	30/18639	0.2	1.11111773472429	0.460565467733193	0.893134988889154
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	8/3355	41/18639	0.195121951219512	1.08401730217004	0.463126935827153	0.893134988889154
GO:0005080	protein kinase C binding	10/3355	52/18639	0.192307692307692	1.0683824372349	0.464435840864384	0.893134988889154
GO:0030159	signaling receptor complex adaptor activity	10/3355	52/18639	0.192307692307692	1.0683824372349	0.464435840864384	0.893134988889154
GO:0004676	3-phosphoinositide-dependent protein kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0004711	ribosomal protein S6 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0035175	histone H3S10 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0035979	histone H2AXS139 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0044022	histone H3S28 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0044023	histone H4S1 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0044024	histone H2AS1 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0044025	histone H2BS14 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0072354	histone H3T3 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0072371	histone H2AS121 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0072518	Rho-dependent protein serine/threonine kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0140823	histone H2BS36 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0140855	histone H3S57 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0140995	histone H2A kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0140997	histone H4 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0140998	histone H2B kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:1990244	histone H2AT120 kinase activity	45/3355	245/18639	0.183673469387755	1.02041424617537	0.46639974151792	0.893134988889154
GO:0005161	platelet-derived growth factor receptor binding	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0005313	L-glutamate transmembrane transporter activity	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0005545	1-phosphatidylinositol binding	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0008494	translation activator activity	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0008559	ABC-type xenobiotic transporter activity	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0071933	Arp2/3 complex binding	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0098821	BMP receptor activity	3/3355	14/18639	0.214285714285714	1.1904832872046	0.474420758302348	0.897698438328516
GO:0015171	amino acid transmembrane transporter activity	19/3355	102/18639	0.186274509803922	1.03486455685106	0.474649892803158	0.897698438328516
GO:0005537	D-mannose binding	5/3355	25/18639	0.2	1.11111773472429	0.477241406668075	0.897698438328516
GO:0140359	ABC-type transporter activity	9/3355	47/18639	0.191489361702128	1.06383612899134	0.477607662328793	0.897698438328516
GO:0140938	histone H3 methyltransferase activity	9/3355	47/18639	0.191489361702128	1.06383612899134	0.477607662328793	0.897698438328516
GO:0016409	palmitoyltransferase activity	7/3355	36/18639	0.194444444444444	1.08025335320417	0.47776532218325	0.897698438328516
GO:0004677	DNA-dependent protein kinase activity	45/3355	246/18639	0.182926829268293	1.01626622078441	0.478405905877984	0.897698438328516
GO:0140857	histone H3T45 kinase activity	45/3355	246/18639	0.182926829268293	1.01626622078441	0.478405905877984	0.897698438328516
GO:0140996	histone H3 kinase activity	65/3355	357/18639	0.182072829131653	1.01152174729802	0.480975064379211	0.901224439138091
GO:0019003	GDP binding	14/3355	75/18639	0.186666666666667	1.03704321907601	0.487149521770119	0.911486067953833
GO:0008307	structural constituent of muscle	8/3355	42/18639	0.19047619047619	1.05820736640409	0.492246187587081	0.916130700197915
GO:0019894	kinesin binding	8/3355	42/18639	0.19047619047619	1.05820736640409	0.492246187587081	0.916130700197915
GO:0048487	beta-tubulin binding	8/3355	42/18639	0.19047619047619	1.05820736640409	0.492246187587081	0.916130700197915
GO:0005310	dicarboxylic acid transmembrane transporter activity	6/3355	31/18639	0.193548387096774	1.07527522715254	0.49454222330745	0.916130700197915
GO:0016411	acylglycerol O-acyltransferase activity	6/3355	31/18639	0.193548387096774	1.07527522715254	0.49454222330745	0.916130700197915
GO:0017147	Wnt-protein binding	6/3355	31/18639	0.193548387096774	1.07527522715254	0.49454222330745	0.916130700197915
GO:0070325	lipoprotein particle receptor binding	6/3355	31/18639	0.193548387096774	1.07527522715254	0.49454222330745	0.916130700197915
GO:0052745	inositol phosphate phosphatase activity	4/3355	20/18639	0.2	1.11111773472429	0.497452811414691	0.920217240379017
GO:0004679	AMP-activated protein kinase activity	45/3355	248/18639	0.181451612903226	1.00807052545551	0.502359401192648	0.927979318186137
GO:0004725	protein tyrosine phosphatase activity	18/3355	98/18639	0.183673469387755	1.02041424617537	0.503515086947879	0.928800428748488
GO:0141003	histone H2AX kinase activity	64/3355	354/18639	0.180790960451977	1.00440021218015	0.506506667224277	0.933000997736116
GO:0019213	deacetylase activity	7/3355	37/18639	0.189189189189189	1.05105731663109	0.508761214262507	0.935834008206809
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	10/3355	54/18639	0.185185185185185	1.02881271733731	0.515893069418184	0.946921887263652
GO:0004222	metalloendopeptidase activity	20/3355	110/18639	0.181818181818182	1.01010703156754	0.519244105977848	0.946921887263652
GO:0061659	ubiquitin-like protein ligase activity	67/3355	372/18639	0.18010752688172	1.00060333637806	0.519417392134916	0.946921887263652
GO:0004865	protein serine/threonine phosphatase inhibitor activity	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0008242	omega peptidase activity	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0031386	protein tag activity	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0034483	heparan sulfate sulfotransferase activity	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0042809	nuclear vitamin D receptor binding	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0045504	dynein heavy chain binding	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0050780	dopamine receptor binding	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0140161	monocarboxylate:sodium symporter activity	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0141047	molecular tag activity	3/3355	15/18639	0.2	1.11111773472429	0.523489741657241	0.946921887263652
GO:0004197	cysteine-type endopeptidase activity	16/3355	88/18639	0.181818181818182	1.01010703156754	0.525903694048702	0.949972647894335
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6/3355	32/18639	0.1875	1.04167287630402	0.527761993779487	0.950699536380704
GO:0043425	bHLH transcription factor binding	6/3355	32/18639	0.1875	1.04167287630402	0.527761993779487	0.950699536380704
GO:0008373	sialyltransferase activity	4/3355	21/18639	0.19047619047619	1.05820736640409	0.538480943761136	0.968672331338904
GO:0008374	O-acyltransferase activity	10/3355	55/18639	0.181818181818182	1.01010703156754	0.541054606583839	0.971963296008932
GO:0005518	collagen binding	13/3355	72/18639	0.180555555555556	1.00309239940387	0.543320622865378	0.974693315195306
GO:0046982	protein heterodimerization activity	66/3355	369/18639	0.178861788617886	0.993682526989204	0.54457968526924	0.975611891579736
GO:0023026	MHC class II protein complex binding	5/3355	27/18639	0.185185185185185	1.02881271733731	0.550208099529904	0.976693520845839
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	5/3355	27/18639	0.185185185185185	1.02881271733731	0.550208099529904	0.976693520845839
GO:0005201	extracellular matrix structural constituent	30/3355	168/18639	0.178571428571429	0.992069406003832	0.551062195896219	0.976693520845839
GO:0061630	ubiquitin protein ligase activity	63/3355	353/18639	0.178470254957507	0.991507327020261	0.552217005960014	0.976693520845839
GO:0004862	cAMP-dependent protein kinase inhibitor activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0005345	purine nucleobase transmembrane transporter activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0005381	iron ion transmembrane transporter activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0015187	glycine transmembrane transporter activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0031419	cobalamin binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0031956	medium-chain fatty acid-CoA ligase activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0035256	G protein-coupled glutamate receptor binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0035374	chondroitin sulfate binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0042975	peroxisome proliferator activated receptor binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0043121	neurotrophin binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0043208	glycosphingolipid binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0043295	glutathione binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0050308	sugar-phosphatase activity	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0070097	delta-catenin binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:1905394	retromer complex binding	2/3355	10/18639	0.2	1.11111773472429	0.560888315952817	0.976693520845839
GO:0005159	insulin-like growth factor receptor binding	3/3355	16/18639	0.1875	1.04167287630402	0.569917521804193	0.985844084074538
GO:0030275	LRR domain binding	3/3355	16/18639	0.1875	1.04167287630402	0.569917521804193	0.985844084074538
GO:0031435	mitogen-activated protein kinase kinase kinase binding	3/3355	16/18639	0.1875	1.04167287630402	0.569917521804193	0.985844084074538
GO:0070411	I-SMAD binding	3/3355	16/18639	0.1875	1.04167287630402	0.569917521804193	0.985844084074538
GO:0140327	flippase activity	3/3355	16/18639	0.1875	1.04167287630402	0.569917521804193	0.985844084074538
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4/3355	22/18639	0.181818181818182	1.01010703156754	0.577731807403242	0.996720925321841
GO:0140784	metal ion sensor activity	4/3355	22/18639	0.181818181818182	1.01010703156754	0.577731807403242	0.996720925321841
GO:0032934	sterol binding	12/3355	68/18639	0.176470588235294	0.980398001227317	0.579810610947596	0.997159382554172
GO:0042277	peptide binding	44/3355	249/18639	0.176706827309237	0.98171044835078	0.580261865845938	0.997159382554172
GO:0031406	carboxylic acid binding	33/3355	187/18639	0.176470588235294	0.980398001227317	0.580276516647144	0.997159382554172
GO:0019789	SUMO transferase activity	5/3355	28/18639	0.178571428571429	0.992069406003832	0.584776768817924	1
GO:0046875	ephrin receptor binding	5/3355	28/18639	0.178571428571429	0.992069406003832	0.584776768817924	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	5/3355	28/18639	0.178571428571429	0.992069406003832	0.584776768817924	1
GO:0008376	acetylgalactosaminyltransferase activity	6/3355	34/18639	0.176470588235294	0.980398001227317	0.591248786767505	1
GO:0016279	protein-lysine N-methyltransferase activity	12/3355	69/18639	0.173913043478261	0.966189334542863	0.6015371033627	1
GO:0035401	histone H3Y41 kinase activity	20/3355	115/18639	0.173913043478261	0.966189334542863	0.605702823552211	1
GO:0140801	histone H2AXY142 kinase activity	20/3355	115/18639	0.173913043478261	0.966189334542863	0.605702823552211	1
GO:0043177	organic acid binding	33/3355	189/18639	0.174603174603175	0.970023419203747	0.606687290470322	1
GO:0005319	lipid transporter activity	31/3355	178/18639	0.174157303370787	0.967546342035198	0.611367508786025	1
GO:0030169	low-density lipoprotein particle binding	3/3355	17/18639	0.176470588235294	0.980398001227317	0.613427383227416	1
GO:0031489	myosin V binding	3/3355	17/18639	0.176470588235294	0.980398001227317	0.613427383227416	1
GO:0070492	oligosaccharide binding	3/3355	17/18639	0.176470588235294	0.980398001227317	0.613427383227416	1
GO:0099186	structural constituent of postsynapse	4/3355	23/18639	0.173913043478261	0.966189334542863	0.614999615987723	1
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0004143	ATP-dependent diacylglycerol kinase activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0008046	axon guidance receptor activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0008172	S-methyltransferase activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0008271	secondary active sulfate transmembrane transporter activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0015205	nucleobase transmembrane transporter activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0019203	carbohydrate phosphatase activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0034056	estrogen response element binding	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0034713	type I transforming growth factor beta receptor binding	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0045294	alpha-catenin binding	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0098973	structural constituent of postsynaptic actin cytoskeleton	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0180030	inositol phosphate kinase activity	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:1900750	oligopeptide binding	2/3355	11/18639	0.181818181818182	1.01010703156754	0.61521319664981	1
GO:0005416	amino acid:monoatomic cation symporter activity	5/3355	29/18639	0.172413793103448	0.957860116141631	0.617847419096713	1
GO:0010484	histone H3 acetyltransferase activity	5/3355	29/18639	0.172413793103448	0.957860116141631	0.617847419096713	1
GO:0043236	laminin binding	5/3355	29/18639	0.172413793103448	0.957860116141631	0.617847419096713	1
GO:0005343	organic acid:sodium symporter activity	6/3355	35/18639	0.171428571428571	0.952386629763679	0.621245112257507	1
GO:0016278	lysine N-methyltransferase activity	12/3355	70/18639	0.171428571428571	0.952386629763679	0.622731114560155	1
GO:0098631	cell adhesion mediator activity	13/3355	76/18639	0.171052631578947	0.950298062593145	0.627159030407416	1
GO:0001784	phosphotyrosine residue binding	8/3355	47/18639	0.170212765957447	0.945632114658972	0.62861285341965	1
GO:0005504	fatty acid binding	8/3355	47/18639	0.170212765957447	0.945632114658972	0.62861285341965	1
GO:0043495	protein-membrane adaptor activity	8/3355	47/18639	0.170212765957447	0.945632114658972	0.62861285341965	1
GO:0005246	calcium channel regulator activity	9/3355	53/18639	0.169811320754717	0.943401850237606	0.632357297407747	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	5/3355	30/18639	0.166666666666667	0.925931445603577	0.649303809369418	1
GO:0098918	structural constituent of synapse	5/3355	30/18639	0.166666666666667	0.925931445603577	0.649303809369418	1
GO:0005484	SNAP receptor activity	6/3355	36/18639	0.166666666666667	0.925931445603577	0.649941070272358	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	6/3355	36/18639	0.166666666666667	0.925931445603577	0.649941070272358	1
GO:0015295	solute:proton symporter activity	4/3355	24/18639	0.166666666666667	0.925931445603577	0.650142883217441	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	4/3355	24/18639	0.166666666666667	0.925931445603577	0.650142883217441	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4/3355	24/18639	0.166666666666667	0.925931445603577	0.650142883217441	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4/3355	24/18639	0.166666666666667	0.925931445603577	0.650142883217441	1
GO:0008409	5'-3' exonuclease activity	3/3355	18/18639	0.166666666666667	0.925931445603577	0.653862441856473	1
GO:0017075	syntaxin-1 binding	3/3355	18/18639	0.166666666666667	0.925931445603577	0.653862441856473	1
GO:0035615	clathrin adaptor activity	3/3355	18/18639	0.166666666666667	0.925931445603577	0.653862441856473	1
GO:0004000	adenosine deaminase activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0005078	MAP-kinase scaffold activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0008179	adenylate cyclase binding	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0008499	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0008603	cAMP-dependent protein kinase regulator activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0010853	cyclase activator activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0015166	polyol transmembrane transporter activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0097371	MDM2/MDM4 family protein binding	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0097677	STAT family protein binding	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0140829	bicarbonate:monoatomic anion antiporter activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0140900	chloride:bicarbonate antiporter activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:1990817	poly(A) RNA polymerase activity	2/3355	12/18639	0.166666666666667	0.925931445603577	0.664214367355804	1
GO:0019199	transmembrane receptor protein kinase activity	13/3355	78/18639	0.166666666666667	0.925931445603577	0.666050960952917	1
GO:0008200	ion channel inhibitor activity	7/3355	43/18639	0.162790697674419	0.904398156170935	0.67678753225306	1
GO:0008238	exopeptidase activity	17/3355	102/18639	0.166666666666667	0.925931445603577	0.676877367962273	1
GO:0030551	cyclic nucleotide binding	6/3355	37/18639	0.162162162162162	0.900906271398075	0.677266203693619	1
GO:0004709	MAP kinase kinase kinase activity	4/3355	25/18639	0.16	0.888894187779434	0.683076497798272	1
GO:0008483	transaminase activity	4/3355	25/18639	0.16	0.888894187779434	0.683076497798272	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	4/3355	25/18639	0.16	0.888894187779434	0.683076497798272	1
GO:0120227	acyl-CoA binding	3/3355	19/18639	0.157894736842105	0.877198211624441	0.691163246001415	1
GO:1990380	K48-linked deubiquitinase activity	3/3355	19/18639	0.157894736842105	0.877198211624441	0.691163246001415	1
GO:0170055	lipid transmembrane transporter activity	9/3355	56/18639	0.160714285714286	0.892862465403449	0.699584256824311	1
GO:0005007	fibroblast growth factor receptor activity	8/3355	50/18639	0.16	0.888894187779434	0.699890858823535	1
GO:0016248	channel inhibitor activity	7/3355	44/18639	0.159090909090909	0.883843652621596	0.700969962379365	1
GO:0048306	calcium-dependent protein binding	13/3355	80/18639	0.1625	0.902783159463487	0.702573459597162	1
GO:0015106	bicarbonate transmembrane transporter activity	5/3355	32/18639	0.15625	0.868060730253353	0.707084848965722	1
GO:0071813	lipoprotein particle binding	5/3355	32/18639	0.15625	0.868060730253353	0.707084848965722	1
GO:0071814	protein-lipid complex binding	5/3355	32/18639	0.15625	0.868060730253353	0.707084848965722	1
GO:0005172	vascular endothelial growth factor receptor binding	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0008417	fucosyltransferase activity	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0031432	titin binding	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0039706	co-receptor binding	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0046975	histone H3K36 methyltransferase activity	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0070700	BMP receptor binding	2/3355	13/18639	0.153846153846154	0.854705949787917	0.70804774010582	1
GO:0051015	actin filament binding	35/3355	209/18639	0.167464114832536	0.93036173960168	0.709438874601754	1
GO:0008157	protein phosphatase 1 binding	4/3355	26/18639	0.153846153846154	0.854705949787917	0.71376367358893	1
GO:0051139	metal cation:proton antiporter activity	4/3355	26/18639	0.153846153846154	0.854705949787917	0.71376367358893	1
GO:0052742	phosphatidylinositol kinase activity	4/3355	26/18639	0.153846153846154	0.854705949787917	0.71376367358893	1
GO:0070412	R-SMAD binding	4/3355	26/18639	0.153846153846154	0.854705949787917	0.71376367358893	1
GO:0097602	cullin family protein binding	4/3355	26/18639	0.153846153846154	0.854705949787917	0.71376367358893	1
GO:0004713	protein tyrosine kinase activity	23/3355	140/18639	0.164285714285714	0.912703853523526	0.71931080707523	1
GO:0005030	neurotrophin receptor activity	8/3355	51/18639	0.156862745098039	0.871464889979837	0.72157299605804	1
GO:0016597	amino acid binding	8/3355	51/18639	0.156862745098039	0.871464889979837	0.72157299605804	1
GO:0141110	transporter inhibitor activity	7/3355	45/18639	0.155555555555556	0.864202682563338	0.723929188167245	1
GO:0010851	cyclase regulator activity	3/3355	20/18639	0.15	0.833338301043219	0.725347440340249	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	3/3355	20/18639	0.15	0.833338301043219	0.725347440340249	1
GO:0042288	MHC class I protein binding	3/3355	20/18639	0.15	0.833338301043219	0.725347440340249	1
GO:1901681	sulfur compound binding	46/3355	275/18639	0.167272727272727	0.929298469042135	0.733190062060253	1
GO:0071889	14-3-3 protein binding	5/3355	33/18639	0.151515151515152	0.841755859639615	0.733341564963314	1
GO:0140311	protein sequestering activity	5/3355	33/18639	0.151515151515152	0.841755859639615	0.733341564963314	1
GO:0017022	myosin binding	12/3355	76/18639	0.157894736842105	0.877198211624441	0.73670886763058	1
GO:0004683	calcium/calmodulin-dependent protein kinase activity	4/3355	27/18639	0.148148148148148	0.823050173869846	0.742208121251369	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	4/3355	27/18639	0.148148148148148	0.823050173869846	0.742208121251369	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	21/3355	130/18639	0.161538461538462	0.897441247277313	0.742314678349811	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	21/3355	130/18639	0.161538461538462	0.897441247277313	0.742314678349811	1
GO:0008392	arachidonate epoxygenase activity	2/3355	14/18639	0.142857142857143	0.793655524803066	0.746985570406398	1
GO:0032036	myosin heavy chain binding	2/3355	14/18639	0.142857142857143	0.793655524803066	0.746985570406398	1
GO:0032454	histone H3K9 demethylase activity	2/3355	14/18639	0.142857142857143	0.793655524803066	0.746985570406398	1
GO:0034236	protein kinase A catalytic subunit binding	2/3355	14/18639	0.142857142857143	0.793655524803066	0.746985570406398	1
GO:0046030	inositol trisphosphate phosphatase activity	2/3355	14/18639	0.142857142857143	0.793655524803066	0.746985570406398	1
GO:0061665	SUMO ligase activity	2/3355	14/18639	0.142857142857143	0.793655524803066	0.746985570406398	1
GO:0032451	demethylase activity	6/3355	40/18639	0.15	0.833338301043219	0.750639500414669	1
GO:0038024	cargo receptor activity	10/3355	65/18639	0.153846153846154	0.854705949787917	0.756108211769977	1
GO:0001846	opsonin binding	3/3355	21/18639	0.142857142857143	0.793655524803066	0.756491856436768	1
GO:0010314	phosphatidylinositol-5-phosphate binding	3/3355	21/18639	0.142857142857143	0.793655524803066	0.756491856436768	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	3/3355	21/18639	0.142857142857143	0.793655524803066	0.756491856436768	1
GO:0061891	calcium ion sensor activity	3/3355	21/18639	0.142857142857143	0.793655524803066	0.756491856436768	1
GO:0140312	cargo adaptor activity	3/3355	21/18639	0.142857142857143	0.793655524803066	0.756491856436768	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	5/3355	34/18639	0.147058823529412	0.816998334356097	0.757840319824661	1
GO:0070888	E-box binding	9/3355	59/18639	0.152542372881356	0.847462679027002	0.758461802279242	1
GO:0005003	ephrin receptor activity	8/3355	53/18639	0.150943396226415	0.838579422433428	0.761703227578887	1
GO:0005005	transmembrane-ephrin receptor activity	8/3355	53/18639	0.150943396226415	0.838579422433428	0.761703227578887	1
GO:0036408	histone H3K14 acetyltransferase activity	4/3355	28/18639	0.142857142857143	0.793655524803066	0.768446679990276	1
GO:0050698	proteoglycan sulfotransferase activity	4/3355	28/18639	0.142857142857143	0.793655524803066	0.768446679990276	1
GO:0051019	mitogen-activated protein kinase binding	4/3355	28/18639	0.142857142857143	0.793655524803066	0.768446679990276	1
GO:0001727	lipid kinase activity	6/3355	41/18639	0.146341463414634	0.813012976627531	0.772197729908158	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	9/3355	60/18639	0.15	0.833338301043219	0.77617003168081	1
GO:0005154	epidermal growth factor receptor binding	5/3355	35/18639	0.142857142857143	0.793655524803066	0.78060618775252	1
GO:0004089	carbonate dehydratase activity	2/3355	15/18639	0.133333333333333	0.740745156482861	0.781369544060115	1
GO:0015116	sulfate transmembrane transporter activity	2/3355	15/18639	0.133333333333333	0.740745156482861	0.781369544060115	1
GO:0015929	hexosaminidase activity	2/3355	15/18639	0.133333333333333	0.740745156482861	0.781369544060115	1
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	2/3355	15/18639	0.133333333333333	0.740745156482861	0.781369544060115	1
GO:0033130	acetylcholine receptor binding	2/3355	15/18639	0.133333333333333	0.740745156482861	0.781369544060115	1
GO:0048531	beta-1,3-galactosyltransferase activity	2/3355	15/18639	0.133333333333333	0.740745156482861	0.781369544060115	1
GO:0046332	SMAD binding	12/3355	79/18639	0.151898734177215	0.843886887132374	0.784293237018617	1
GO:0008093	cytoskeletal anchor activity	3/3355	22/18639	0.136363636363636	0.757580273675654	0.784717127336799	1
GO:0031683	G-protein beta/gamma-subunit complex binding	3/3355	22/18639	0.136363636363636	0.757580273675654	0.784717127336799	1
GO:0033691	sialic acid binding	3/3355	22/18639	0.136363636363636	0.757580273675654	0.784717127336799	1
GO:0016500	protein-hormone receptor activity	10/3355	67/18639	0.149253731343284	0.829192339346487	0.789319966090876	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	10/3355	67/18639	0.149253731343284	0.829192339346487	0.789319966090876	1
GO:0050840	extracellular matrix binding	10/3355	67/18639	0.149253731343284	0.829192339346487	0.789319966090876	1
GO:0042056	chemoattractant activity	6/3355	42/18639	0.142857142857143	0.793655524803066	0.792328925471891	1
GO:0003785	actin monomer binding	4/3355	29/18639	0.137931034482759	0.766288092913305	0.792542561733246	1
GO:0004033	aldo-keto reductase (NADPH) activity	5/3355	36/18639	0.138888888888889	0.771609538002981	0.801681206700933	1
GO:0005004	GPI-linked ephrin receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0005008	hepatocyte growth factor receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0005009	insulin receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0005011	macrophage colony-stimulating factor receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0005018	platelet-derived growth factor alpha-receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0005020	stem cell factor receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0008288	boss receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0036332	placental growth factor receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0038062	protein tyrosine kinase collagen receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0060175	brain-derived neurotrophic factor receptor activity	7/3355	49/18639	0.142857142857143	0.793655524803066	0.803422027934915	1
GO:0005516	calmodulin binding	33/3355	207/18639	0.159420289855072	0.885673556664291	0.805467317565677	1
GO:0004022	alcohol dehydrogenase (NAD+) activity	3/3355	23/18639	0.130434782608696	0.724642000907147	0.81017475403916	1
GO:0005212	structural constituent of eye lens	3/3355	23/18639	0.130434782608696	0.724642000907147	0.81017475403916	1
GO:0031681	G-protein beta-subunit binding	3/3355	23/18639	0.130434782608696	0.724642000907147	0.81017475403916	1
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	3/3355	23/18639	0.130434782608696	0.724642000907147	0.81017475403916	1
GO:0140103	catalytic activity, acting on a glycoprotein	3/3355	23/18639	0.130434782608696	0.724642000907147	0.81017475403916	1
GO:0008375	acetylglucosaminyltransferase activity	6/3355	43/18639	0.13953488372093	0.775198419575088	0.811065367615486	1
GO:0000062	fatty-acyl-CoA binding	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0005149	interleukin-1 receptor binding	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0008391	arachidonate monooxygenase activity	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0015378	sodium:chloride symporter activity	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	2/3355	16/18639	0.125	0.694448584202683	0.811576975810961	1
GO:0001965	G-protein alpha-subunit binding	4/3355	30/18639	0.133333333333333	0.740745156482861	0.814579292866143	1
GO:0043995	histone H4K5 acetyltransferase activity	4/3355	30/18639	0.133333333333333	0.740745156482861	0.814579292866143	1
GO:0043996	histone H4K8 acetyltransferase activity	4/3355	30/18639	0.133333333333333	0.740745156482861	0.814579292866143	1
GO:0043997	histone H4K12 acetyltransferase activity	4/3355	30/18639	0.133333333333333	0.740745156482861	0.814579292866143	1
GO:0005006	epidermal growth factor receptor activity	7/3355	50/18639	0.14	0.777782414307004	0.820275939185605	1
GO:0005017	platelet-derived growth factor receptor activity	7/3355	50/18639	0.14	0.777782414307004	0.820275939185605	1
GO:0005019	platelet-derived growth factor beta-receptor activity	7/3355	50/18639	0.14	0.777782414307004	0.820275939185605	1
GO:0023023	MHC protein complex binding	5/3355	37/18639	0.135135135135135	0.750755226165062	0.821121050920826	1
GO:0001223	transcription coactivator binding	6/3355	44/18639	0.136363636363636	0.757580273675654	0.828448852652768	1
GO:0030547	signaling receptor inhibitor activity	6/3355	44/18639	0.136363636363636	0.757580273675654	0.828448852652768	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	3/3355	24/18639	0.125	0.694448584202683	0.833036449870835	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	3/3355	24/18639	0.125	0.694448584202683	0.833036449870835	1
GO:0030215	semaphorin receptor binding	3/3355	24/18639	0.125	0.694448584202683	0.833036449870835	1
GO:0030552	cAMP binding	3/3355	24/18639	0.125	0.694448584202683	0.833036449870835	1
GO:0043998	histone H2A acetyltransferase activity	3/3355	24/18639	0.125	0.694448584202683	0.833036449870835	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	3/3355	24/18639	0.125	0.694448584202683	0.833036449870835	1
GO:0005452	solute:inorganic anion antiporter activity	4/3355	31/18639	0.129032258064516	0.716850151435027	0.834655387684405	1
GO:0047499	calcium-independent phospholipase A2 activity	4/3355	31/18639	0.129032258064516	0.716850151435027	0.834655387684405	1
GO:0005010	insulin-like growth factor receptor activity	7/3355	51/18639	0.137254901960784	0.762531778732357	0.835978680137717	1
GO:0005021	vascular endothelial growth factor receptor activity	7/3355	51/18639	0.137254901960784	0.762531778732357	0.835978680137717	1
GO:0030165	PDZ domain binding	12/3355	83/18639	0.144578313253012	0.803217639559729	0.837742045339145	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	2/3355	17/18639	0.117647058823529	0.653598667484878	0.837996921488766	1
GO:0008429	phosphatidylethanolamine binding	2/3355	17/18639	0.117647058823529	0.653598667484878	0.837996921488766	1
GO:0036041	long-chain fatty acid binding	2/3355	17/18639	0.117647058823529	0.653598667484878	0.837996921488766	1
GO:0045125	bioactive lipid receptor activity	2/3355	17/18639	0.117647058823529	0.653598667484878	0.837996921488766	1
GO:0070403	NAD+ binding	2/3355	17/18639	0.117647058823529	0.653598667484878	0.837996921488766	1
GO:1901567	fatty acid derivative binding	2/3355	17/18639	0.117647058823529	0.653598667484878	0.837996921488766	1
GO:0000146	microfilament motor activity	5/3355	38/18639	0.131578947368421	0.730998509687034	0.838992004271471	1
GO:0005109	frizzled binding	5/3355	38/18639	0.131578947368421	0.730998509687034	0.838992004271471	1
GO:0005501	retinoid binding	5/3355	38/18639	0.131578947368421	0.730998509687034	0.838992004271471	1
GO:0019840	isoprenoid binding	5/3355	38/18639	0.131578947368421	0.730998509687034	0.838992004271471	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	6/3355	45/18639	0.133333333333333	0.740745156482861	0.844528801035156	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	7/3355	52/18639	0.134615384615385	0.747867706064427	0.850569692711684	1
GO:0120013	lipid transfer activity	9/3355	65/18639	0.138461538461538	0.769235354809125	0.850683958167664	1
GO:0047498	calcium-dependent phospholipase A2 activity	4/3355	32/18639	0.125	0.694448584202683	0.852879750358503	1
GO:0030276	clathrin binding	6/3355	46/18639	0.130434782608696	0.724642000907147	0.859360529803882	1
GO:0004706	JUN kinase kinase kinase activity	2/3355	18/18639	0.111111111111111	0.617287630402385	0.861013731442803	1
GO:0015373	monoatomic anion:sodium symporter activity	2/3355	18/18639	0.111111111111111	0.617287630402385	0.861013731442803	1
GO:0031690	adrenergic receptor binding	2/3355	18/18639	0.111111111111111	0.617287630402385	0.861013731442803	1
GO:0034185	apolipoprotein binding	2/3355	18/18639	0.111111111111111	0.617287630402385	0.861013731442803	1
GO:0004445	inositol-polyphosphate 5-phosphatase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0004955	prostaglandin receptor activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0008140	cAMP response element binding protein binding	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0008239	dipeptidyl-peptidase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0008401	retinoic acid 4-hydroxylase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0015203	polyamine transmembrane transporter activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0015279	store-operated calcium channel activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0015643	toxic substance binding	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0019531	oxalate transmembrane transporter activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0019911	structural constituent of myelin sheath	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0032052	bile acid binding	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0043422	protein kinase B binding	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0051864	histone H3K36 demethylase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0070739	protein-glutamic acid ligase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0070740	tubulin-glutamic acid ligase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0140135	mechanosensitive monoatomic cation channel activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0140999	histone H3K4 trimethyltransferase activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0141109	transporter activator activity	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:1990763	arrestin family protein binding	1/3355	10/18639	0.1	0.555558867362146	0.86262302152953	1
GO:0017046	peptide hormone binding	7/3355	53/18639	0.132075471698113	0.733756994629249	0.864092850449283	1
GO:0038064	collagen receptor activity	7/3355	53/18639	0.132075471698113	0.733756994629249	0.864092850449283	1
GO:0033293	monocarboxylic acid binding	11/3355	79/18639	0.139240506329114	0.773562979871343	0.864333998467158	1
GO:0015291	secondary active transmembrane transporter activity	45/3355	287/18639	0.156794425087108	0.871085332100926	0.867137435421703	1
GO:0019956	chemokine binding	4/3355	33/18639	0.121212121212121	0.673404687711692	0.869367775930253	1
GO:0004112	cyclic-nucleotide phosphodiesterase activity	3/3355	26/18639	0.115384615384615	0.641029462340938	0.87171012476464	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	3/3355	26/18639	0.115384615384615	0.641029462340938	0.87171012476464	1
GO:0034237	protein kinase A regulatory subunit binding	3/3355	26/18639	0.115384615384615	0.641029462340938	0.87171012476464	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	2/3355	19/18639	0.105263157894737	0.584798807749627	0.880996141494731	1
GO:0034987	immunoglobulin receptor binding	2/3355	19/18639	0.105263157894737	0.584798807749627	0.880996141494731	1
GO:0042800	histone H3K4 methyltransferase activity	2/3355	19/18639	0.105263157894737	0.584798807749627	0.880996141494731	1
GO:0001530	lipopolysaccharide binding	5/3355	41/18639	0.121951219512195	0.677510813856276	0.883958916503474	1
GO:0017080	sodium channel regulator activity	5/3355	41/18639	0.121951219512195	0.677510813856276	0.883958916503474	1
GO:0140828	metal cation:monoatomic cation antiporter activity	5/3355	41/18639	0.121951219512195	0.677510813856276	0.883958916503474	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4/3355	34/18639	0.117647058823529	0.653598667484878	0.884238103410999	1
GO:0030971	receptor tyrosine kinase binding	11/3355	81/18639	0.135802469135802	0.754462659380692	0.884596465312689	1
GO:0042562	hormone binding	13/3355	94/18639	0.138297872340426	0.768326093160415	0.885808005818923	1
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0003953	NAD+ nucleosidase activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0004016	adenylate cyclase activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0004117	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0004954	prostanoid receptor activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0005114	type II transforming growth factor beta receptor binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0008199	ferric iron binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0008432	JUN kinase binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0008503	benzodiazepine receptor activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0016594	glycine binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0031731	CCR6 chemokine receptor binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0032050	clathrin heavy chain binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0042608	T cell receptor binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0043522	leucine zipper domain binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0048101	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0050998	nitric-oxide synthase binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0070697	activin receptor binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0140031	phosphorylation-dependent protein binding	1/3355	11/18639	0.0909090909090909	0.505053515783769	0.887364004017501	1
GO:0035255	ionotropic glutamate receptor binding	3/3355	27/18639	0.111111111111111	0.617287630402385	0.887897875203799	1
GO:0030295	protein kinase activator activity	20/3355	139/18639	0.143884892086331	0.799365276780066	0.891982116756822	1
GO:0003730	mRNA 3'-UTR binding	40/3355	262/18639	0.152671755725191	0.848181476888773	0.894501148103918	1
GO:0004623	phospholipase A2 activity	4/3355	35/18639	0.114285714285714	0.634924419842453	0.897609963495964	1
GO:0005326	neurotransmitter transmembrane transporter activity	2/3355	20/18639	0.1	0.555558867362146	0.898290441623007	1
GO:0003779	actin binding	70/3355	443/18639	0.158013544018059	0.877858255425513	0.901585025870741	1
GO:0045499	chemorepellent activity	3/3355	28/18639	0.107142857142857	0.595241643602299	0.902232018629422	1
GO:0046966	nuclear thyroid hormone receptor binding	3/3355	28/18639	0.107142857142857	0.595241643602299	0.902232018629422	1
GO:0051393	alpha-actinin binding	3/3355	28/18639	0.107142857142857	0.595241643602299	0.902232018629422	1
GO:0141052	histone H3 demethylase activity	3/3355	28/18639	0.107142857142857	0.595241643602299	0.902232018629422	1
GO:0015294	solute:monoatomic cation symporter activity	16/3355	116/18639	0.137931034482759	0.766288092913305	0.907577028805206	1
GO:0004032	aldose reductase (NADPH) activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0004126	cytidine deaminase activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0004875	complement receptor activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0005165	neurotrophin receptor binding	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0005247	voltage-gated chloride channel activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0005436	sodium:phosphate symporter activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0015132	prostaglandin transmembrane transporter activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0015368	calcium:monoatomic cation antiporter activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0035497	cAMP response element binding	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0042301	phosphate ion binding	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0045295	gamma-catenin binding	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0070008	serine-type exopeptidase activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0140822	NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0140844	NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0140867	NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	1/3355	12/18639	0.0833333333333333	0.462965722801788	0.90765033462311	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	4/3355	36/18639	0.111111111111111	0.617287630402385	0.909601058095343	1
GO:0019209	kinase activator activity	21/3355	148/18639	0.141891891891892	0.788292987473315	0.909664539318535	1
GO:0009975	cyclase activity	2/3355	21/18639	0.0952380952380952	0.529103683202044	0.913216608484716	1
GO:0051428	peptide hormone receptor binding	2/3355	21/18639	0.0952380952380952	0.529103683202044	0.913216608484716	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	12/3355	91/18639	0.131868131868132	0.732605099818215	0.913541889693879	1
GO:0072341	modified amino acid binding	12/3355	91/18639	0.131868131868132	0.732605099818215	0.913541889693879	1
GO:0004181	metallocarboxypeptidase activity	3/3355	29/18639	0.103448275862069	0.574716069684979	0.914888494425134	1
GO:0030246	carbohydrate binding	42/3355	280/18639	0.15	0.833338301043219	0.921055586199222	1
GO:0019955	cytokine binding	20/3355	144/18639	0.138888888888889	0.771609538002981	0.922754123053814	1
GO:0004465	lipoprotein lipase activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0004535	poly(A)-specific ribonuclease activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0015651	quaternary ammonium group transmembrane transporter activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0017154	semaphorin receptor activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0046974	histone H3K9 methyltransferase activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0071714	icosanoid transmembrane transporter activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0140806	NAD+-protein-aspartate ADP-ribosyltransferase activity	1/3355	13/18639	0.0769230769230769	0.427352974893959	0.924283884166218	1
GO:0004879	nuclear receptor activity	7/3355	59/18639	0.11864406779661	0.659137639243224	0.925574466244639	1
GO:0015459	potassium channel regulator activity	7/3355	59/18639	0.11864406779661	0.659137639243224	0.925574466244639	1
GO:0031624	ubiquitin conjugating enzyme binding	3/3355	30/18639	0.1	0.555558867362146	0.926033961265022	1
GO:0032452	histone demethylase activity	3/3355	30/18639	0.1	0.555558867362146	0.926033961265022	1
GO:0033612	receptor serine/threonine kinase binding	3/3355	30/18639	0.1	0.555558867362146	0.926033961265022	1
GO:0048019	receptor antagonist activity	3/3355	30/18639	0.1	0.555558867362146	0.926033961265022	1
GO:0005243	gap junction channel activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0008970	phospholipase A1 activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0015377	chloride:monoatomic cation symporter activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0016881	acid-amino acid ligase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0032931	histone H3K56 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0043992	histone H3K9 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0043993	histone H3K18 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0043994	histone H3K23 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0043999	histone H2AK5 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0044012	histone H2AK9 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0044014	histone H2BK5 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0044015	histone H2BK12 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0044016	histone H3K4 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0044017	histone H3K27 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0044018	histone H3K36 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0046972	histone H4K16 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0050321	tau-protein kinase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0140908	histone H3K122 acetyltransferase activity	2/3355	22/18639	0.0909090909090909	0.505053515783769	0.926066556599507	1
GO:0098531	ligand-modulated transcription factor activity	7/3355	60/18639	0.116666666666667	0.648152011922504	0.933024961880039	1
GO:0005096	GTPase activator activity	40/3355	271/18639	0.14760147601476	0.820013088357411	0.933214770332273	1
GO:0008146	sulfotransferase activity	6/3355	53/18639	0.113207547169811	0.628934566825071	0.933478386386297	1
GO:0051018	protein kinase A binding	6/3355	53/18639	0.113207547169811	0.628934566825071	0.933478386386297	1
GO:0005164	tumor necrosis factor receptor binding	3/3355	31/18639	0.0967741935483871	0.53763761357627	0.935824522720088	1
GO:0005184	neuropeptide hormone activity	3/3355	31/18639	0.0967741935483871	0.53763761357627	0.935824522720088	1
GO:0070273	phosphatidylinositol-4-phosphate binding	3/3355	31/18639	0.0967741935483871	0.53763761357627	0.935824522720088	1
GO:0140457	protein demethylase activity	3/3355	31/18639	0.0967741935483871	0.53763761357627	0.935824522720088	1
GO:0003950	NAD+ poly-ADP-ribosyltransferase activity	2/3355	23/18639	0.0869565217391304	0.483094667271431	0.937103871129064	1
GO:0005158	insulin receptor binding	2/3355	23/18639	0.0869565217391304	0.483094667271431	0.937103871129064	1
GO:0016493	C-C chemokine receptor activity	2/3355	23/18639	0.0869565217391304	0.483094667271431	0.937103871129064	1
GO:0044013	histone H2B acetyltransferase activity	2/3355	23/18639	0.0869565217391304	0.483094667271431	0.937103871129064	1
GO:1990404	NAD+-protein mono-ADP-ribosyltransferase activity	2/3355	23/18639	0.0869565217391304	0.483094667271431	0.937103871129064	1
GO:0005496	steroid binding	14/3355	108/18639	0.12962962962963	0.720168902136115	0.937220247710664	1
GO:0004065	arylsulfatase activity	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0008191	metalloendopeptidase inhibitor activity	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0015926	glucosidase activity	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0030283	testosterone dehydrogenase [NAD(P)+] activity	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0031404	chloride ion binding	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0042813	Wnt receptor activity	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0043176	amine binding	1/3355	14/18639	0.0714285714285714	0.396827762401533	0.937922215993896	1
GO:0005539	glycosaminoglycan binding	35/3355	242/18639	0.144628099173554	0.803494229655996	0.939712858017968	1
GO:0015026	coreceptor activity	7/3355	61/18639	0.114754098360656	0.637526569104102	0.939811506965157	1
GO:0120015	sterol transfer activity	3/3355	32/18639	0.09375	0.520836438152012	0.944405016412666	1
GO:0160041	neuropeptide activity	3/3355	32/18639	0.09375	0.520836438152012	0.944405016412666	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	4/3355	40/18639	0.1	0.555558867362146	0.945976609554888	1
GO:0004622	lysophospholipase activity	2/3355	24/18639	0.0833333333333333	0.462965722801788	0.946564545788903	1
GO:0004806	triacylglycerol lipase activity	2/3355	24/18639	0.0833333333333333	0.462965722801788	0.946564545788903	1
GO:0015149	hexose transmembrane transporter activity	2/3355	24/18639	0.0833333333333333	0.462965722801788	0.946564545788903	1
GO:0019957	C-C chemokine binding	2/3355	24/18639	0.0833333333333333	0.462965722801788	0.946564545788903	1
GO:0055056	D-glucose transmembrane transporter activity	2/3355	24/18639	0.0833333333333333	0.462965722801788	0.946564545788903	1
GO:1990782	protein tyrosine kinase binding	15/3355	117/18639	0.128205128205128	0.712254958156597	0.948486017063682	1
GO:0004953	icosanoid receptor activity	1/3355	15/18639	0.0666666666666667	0.370372578241431	0.949104549703452	1
GO:0005523	tropomyosin binding	1/3355	15/18639	0.0666666666666667	0.370372578241431	0.949104549703452	1
GO:0015250	water channel activity	1/3355	15/18639	0.0666666666666667	0.370372578241431	0.949104549703452	1
GO:0017081	chloride channel regulator activity	1/3355	15/18639	0.0666666666666667	0.370372578241431	0.949104549703452	1
GO:0030553	cGMP binding	1/3355	15/18639	0.0666666666666667	0.370372578241431	0.949104549703452	1
GO:0031005	filamin binding	1/3355	15/18639	0.0666666666666667	0.370372578241431	0.949104549703452	1
GO:0019239	deaminase activity	3/3355	33/18639	0.0909090909090909	0.505053515783769	0.951908740460907	1
GO:0001848	complement binding	2/3355	25/18639	0.08	0.444447093889717	0.954658372879733	1
GO:0003707	nuclear steroid receptor activity	2/3355	25/18639	0.08	0.444447093889717	0.954658372879733	1
GO:0015296	monoatomic anion:monoatomic cation symporter activity	2/3355	25/18639	0.08	0.444447093889717	0.954658372879733	1
GO:0120020	cholesterol transfer activity	2/3355	25/18639	0.08	0.444447093889717	0.954658372879733	1
GO:0035254	glutamate receptor binding	5/3355	49/18639	0.102040816326531	0.566896803430761	0.955017222185905	1
GO:0004497	monooxygenase activity	13/3355	106/18639	0.122641509433962	0.68134578072716	0.957962984986264	1
GO:0008013	beta-catenin binding	13/3355	106/18639	0.122641509433962	0.68134578072716	0.957962984986264	1
GO:0015385	sodium:proton antiporter activity	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0022841	potassium ion leak channel activity	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0055102	lipase inhibitor activity	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0061809	NAD+ nucleosidase activity, cyclic ADP-ribose generating	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	1/3355	16/18639	0.0625	0.347224292101341	0.958273054629618	1
GO:0008201	heparin binding	23/3355	172/18639	0.133720930232558	0.742898485426125	0.958397351918568	1
GO:0015370	solute:sodium symporter activity	9/3355	79/18639	0.113924050632911	0.63291516534928	0.960083959242437	1
GO:0001637	G protein-coupled chemoattractant receptor activity	2/3355	26/18639	0.0769230769230769	0.427352974893959	0.961570726889324	1
GO:0004950	chemokine receptor activity	2/3355	26/18639	0.0769230769230769	0.427352974893959	0.961570726889324	1
GO:0005112	Notch binding	2/3355	26/18639	0.0769230769230769	0.427352974893959	0.961570726889324	1
GO:0005160	transforming growth factor beta receptor binding	2/3355	26/18639	0.0769230769230769	0.427352974893959	0.961570726889324	1
GO:0015145	monosaccharide transmembrane transporter activity	2/3355	26/18639	0.0769230769230769	0.427352974893959	0.961570726889324	1
GO:0008081	phosphoric diester hydrolase activity	10/3355	87/18639	0.114942528735632	0.638573410761087	0.963883950813722	1
GO:0016247	channel regulator activity	22/3355	168/18639	0.130952380952381	0.72751756440281	0.96532694722784	1
GO:0008484	sulfuric ester hydrolase activity	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0015278	intracellularly gated calcium channel activity	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0016805	dipeptidase activity	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0030548	acetylcholine receptor regulator activity	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0045236	CXCR chemokine receptor binding	1/3355	17/18639	0.0588235294117647	0.326799333742439	0.965790312950922	1
GO:0031593	polyubiquitin modification-dependent protein binding	6/3355	59/18639	0.101694915254237	0.564975119351335	0.966909255407291	1
GO:0004620	phospholipase activity	13/3355	109/18639	0.119266055045872	0.662593144560358	0.96797794323205	1
GO:0004190	aspartic-type endopeptidase activity	3/3355	36/18639	0.0833333333333333	0.462965722801788	0.969122052290306	1
GO:0045505	dynein intermediate chain binding	3/3355	36/18639	0.0833333333333333	0.462965722801788	0.969122052290306	1
GO:0141108	transporter regulator activity	22/3355	170/18639	0.129411764705882	0.718958534233366	0.970181844822957	1
GO:0004970	glutamate-gated receptor activity	1/3355	18/18639	0.0555555555555556	0.308643815201192	0.971953641274929	1
GO:0005372	water transmembrane transporter activity	1/3355	18/18639	0.0555555555555556	0.308643815201192	0.971953641274929	1
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	1/3355	18/18639	0.0555555555555556	0.308643815201192	0.971953641274929	1
GO:0050811	GABA receptor binding	1/3355	18/18639	0.0555555555555556	0.308643815201192	0.971953641274929	1
GO:0099602	neurotransmitter receptor regulator activity	1/3355	18/18639	0.0555555555555556	0.308643815201192	0.971953641274929	1
GO:0051119	sugar transmembrane transporter activity	2/3355	28/18639	0.0714285714285714	0.396827762401533	0.972482442439146	1
GO:0042605	peptide antigen binding	4/3355	45/18639	0.0888888888888889	0.493830104321908	0.972521478167913	1
GO:1902936	phosphatidylinositol bisphosphate binding	13/3355	111/18639	0.117117117117117	0.650654529343054	0.9734120080547	1
GO:0042805	actinin binding	3/3355	37/18639	0.0810810810810811	0.450453135699037	0.973427594482113	1
GO:0070001	aspartic-type peptidase activity	3/3355	37/18639	0.0810810810810811	0.450453135699037	0.973427594482113	1
GO:0001540	amyloid-beta binding	9/3355	83/18639	0.108433734939759	0.602413229669797	0.973763851236631	1
GO:0015293	symporter activity	18/3355	146/18639	0.123287671232877	0.684935589898536	0.975641872895937	1
GO:0004180	carboxypeptidase activity	4/3355	46/18639	0.0869565217391304	0.483094667271431	0.976087128719114	1
GO:0004629	phospholipase C activity	2/3355	29/18639	0.0689655172413793	0.383144046456652	0.976748660810554	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/3355	29/18639	0.0689655172413793	0.383144046456652	0.976748660810554	1
GO:0099604	ligand-gated calcium channel activity	2/3355	29/18639	0.0689655172413793	0.383144046456652	0.976748660810554	1
GO:0099106	ion channel regulator activity	20/3355	160/18639	0.125	0.694448584202683	0.976852488590002	1
GO:0008381	mechanosensitive monoatomic ion channel activity	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0022840	leak channel activity	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0022842	narrow pore channel activity	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0030506	ankyrin binding	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0042577	lipid phosphatase activity	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0042834	peptidoglycan binding	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0043395	heparan sulfate proteoglycan binding	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0070003	threonine-type peptidase activity	1/3355	19/18639	0.0526315789473684	0.292399403874814	0.977006835707162	1
GO:0030695	GTPase regulator activity	72/3355	489/18639	0.147239263803681	0.818000786300092	0.977737893858943	1
GO:0035091	phosphatidylinositol binding	39/3355	284/18639	0.137323943661972	0.762915346025482	0.978163340598672	1
GO:0060589	nucleoside-triphosphatase regulator activity	72/3355	490/18639	0.146938775510204	0.816331396940296	0.978802998230716	1
GO:0001972	retinoic acid binding	1/3355	20/18639	0.05	0.277779433681073	0.981149803816854	1
GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	1/3355	20/18639	0.05	0.277779433681073	0.981149803816854	1
GO:0015464	acetylcholine receptor activity	1/3355	20/18639	0.05	0.277779433681073	0.981149803816854	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/3355	20/18639	0.05	0.277779433681073	0.981149803816854	1
GO:0030627	pre-mRNA 5'-splice site binding	1/3355	20/18639	0.05	0.277779433681073	0.981149803816854	1
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	14/3355	122/18639	0.114754098360656	0.637526569104102	0.981886063460148	1
GO:0032266	phosphatidylinositol-3-phosphate binding	4/3355	48/18639	0.0833333333333333	0.462965722801788	0.981952201003073	1
GO:0015144	carbohydrate transmembrane transporter activity	3/3355	40/18639	0.075	0.41666915052161	0.983178024541125	1
GO:0061135	endopeptidase regulator activity	23/3355	184/18639	0.125	0.694448584202683	0.98323285197859	1
GO:1901981	phosphatidylinositol phosphate binding	23/3355	185/18639	0.124324324324324	0.690694808071857	0.984520394978705	1
GO:0005123	death receptor binding	1/3355	21/18639	0.0476190476190476	0.264551841601022	0.984546463583461	1
GO:0036122	BMP binding	1/3355	21/18639	0.0476190476190476	0.264551841601022	0.984546463583461	1
GO:0042287	MHC protein binding	3/3355	41/18639	0.0731707317073171	0.406506488313765	0.98558566660859	1
GO:0061134	peptidase regulator activity	29/3355	226/18639	0.128318584070796	0.71288527227886	0.985995142401489	1
GO:0032813	tumor necrosis factor receptor superfamily binding	4/3355	50/18639	0.08	0.444447093889717	0.986437062247705	1
GO:0070851	growth factor receptor binding	16/3355	139/18639	0.115107913669065	0.639492221424053	0.986458988724443	1
GO:0016849	phosphorus-oxygen lyase activity	1/3355	23/18639	0.0434782608695652	0.241547333635716	0.989614282419334	1
GO:0015020	glucuronosyltransferase activity	2/3355	34/18639	0.0588235294117647	0.326799333742439	0.990110191365728	1
GO:0051427	hormone receptor binding	2/3355	34/18639	0.0588235294117647	0.326799333742439	0.990110191365728	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/3355	24/18639	0.0416666666666667	0.231482861400894	0.991486010098918	1
GO:0016298	lipase activity	14/3355	130/18639	0.107692307692308	0.598294164851542	0.991721502255582	1
GO:0015271	outward rectifier potassium channel activity	1/3355	25/18639	0.04	0.222223546944858	0.993020494983051	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/3355	25/18639	0.04	0.222223546944858	0.993020494983051	1
GO:0140767	enzyme-substrate adaptor activity	15/3355	139/18639	0.107913669064748	0.59952395758505	0.993123864969307	1
GO:0004867	serine-type endopeptidase inhibitor activity	9/3355	95/18639	0.0947368421052632	0.526318926974665	0.993210232249762	1
GO:0004175	endopeptidase activity	55/3355	405/18639	0.135802469135802	0.754462659380692	0.993421837901773	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	3/3355	46/18639	0.0652173913043478	0.362321000453573	0.993431801127565	1
GO:0005085	guanyl-nucleotide exchange factor activity	28/3355	230/18639	0.121739130434783	0.676332534180004	0.9938608796953	1
GO:0043394	proteoglycan binding	2/3355	37/18639	0.0540540540540541	0.300302090466025	0.994128904027739	1
GO:0008083	growth factor activity	18/3355	162/18639	0.111111111111111	0.617287630402385	0.994193215407203	1
GO:0004252	serine-type endopeptidase activity	20/3355	176/18639	0.113636363636364	0.631316894729711	0.994197374723703	1
GO:0004435	phosphatidylinositol phospholipase C activity	1/3355	26/18639	0.0384615384615385	0.213676487446979	0.9942784857068	1
GO:0005227	calcium-activated cation channel activity	1/3355	26/18639	0.0384615384615385	0.213676487446979	0.9942784857068	1
GO:0008066	glutamate receptor activity	1/3355	26/18639	0.0384615384615385	0.213676487446979	0.9942784857068	1
GO:0030247	polysaccharide binding	1/3355	26/18639	0.0384615384615385	0.213676487446979	0.9942784857068	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/3355	26/18639	0.0384615384615385	0.213676487446979	0.9942784857068	1
GO:0005044	scavenger receptor activity	1/3355	27/18639	0.037037037037037	0.205762543467461	0.995309790733055	1
GO:0005104	fibroblast growth factor receptor binding	1/3355	27/18639	0.037037037037037	0.205762543467461	0.995309790733055	1
GO:0008395	steroid hydroxylase activity	1/3355	27/18639	0.037037037037037	0.205762543467461	0.995309790733055	1
GO:0015252	proton channel activity	1/3355	27/18639	0.037037037037037	0.205762543467461	0.995309790733055	1
GO:0008236	serine-type peptidase activity	22/3355	194/18639	0.11340206185567	0.630015210410681	0.996000573297486	1
GO:0051959	dynein light intermediate chain binding	1/3355	28/18639	0.0357142857142857	0.198413881200766	0.996155248077274	1
GO:0001786	phosphatidylserine binding	4/3355	59/18639	0.0677966101694915	0.376650079567557	0.996418113925349	1
GO:0071855	neuropeptide receptor binding	2/3355	40/18639	0.05	0.277779433681073	0.996533149746248	1
GO:0048020	CCR chemokine receptor binding	3/3355	50/18639	0.06	0.333335320417288	0.996547630125689	1
GO:0004866	endopeptidase inhibitor activity	17/3355	161/18639	0.105590062111801	0.58661495311531	0.996805933738619	1
GO:0030414	peptidase inhibitor activity	18/3355	169/18639	0.106508875739645	0.591719503699327	0.997055755150473	1
GO:0017171	serine hydrolase activity	22/3355	198/18639	0.111111111111111	0.617287630402385	0.997230390673988	1
GO:0005217	intracellularly ligand-gated monoatomic ion channel activity	1/3355	30/18639	0.0333333333333333	0.185186289120715	0.997416519828972	1
GO:0022839	monoatomic ion-gated channel activity	1/3355	30/18639	0.0333333333333333	0.185186289120715	0.997416519828972	1
GO:0004896	cytokine receptor activity	8/3355	96/18639	0.0833333333333333	0.462965722801788	0.997719047372684	1
GO:0005544	calcium-dependent phospholipid binding	3/3355	53/18639	0.0566037735849057	0.314467283412535	0.997884165259201	1
GO:0042379	chemokine receptor binding	5/3355	72/18639	0.0694444444444444	0.38580476900149	0.998059954573701	1
GO:0008009	chemokine activity	2/3355	45/18639	0.0444444444444444	0.246915052160954	0.998573533103678	1
GO:0005179	hormone activity	12/3355	132/18639	0.0909090909090909	0.505053515783769	0.998687040926042	1
GO:0005543	phospholipid binding	65/3355	497/18639	0.130784708249497	0.726586043833793	0.998897769811687	1
GO:0008509	monoatomic anion transmembrane transporter activity	14/3355	149/18639	0.0939597315436242	0.522001620340271	0.998919969906553	1
GO:0005253	monoatomic anion channel activity	8/3355	103/18639	0.0776699029126214	0.431502032902638	0.999089191879277	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	6/3355	86/18639	0.0697674418604651	0.387599209787544	0.999090750820823	1
GO:0008188	neuropeptide receptor activity	2/3355	48/18639	0.0416666666666667	0.231482861400894	0.999167070712449	1
GO:0038187	pattern recognition receptor activity	2/3355	48/18639	0.0416666666666667	0.231482861400894	0.999167070712449	1
GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	1/3355	36/18639	0.0277777777777778	0.154321907600596	0.999216403733798	1
GO:0030280	structural constituent of skin epidermis	1/3355	37/18639	0.027027027027027	0.150151045233012	0.999357723170078	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	29/3355	268/18639	0.108208955223881	0.601164446026203	0.999595402995897	1
GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	2/3355	53/18639	0.0377358490566038	0.209644855608357	0.999662706717527	1
GO:0015085	calcium ion transmembrane transporter activity	12/3355	147/18639	0.0816326530612245	0.453517442744609	0.999788158834874	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/3355	56/18639	0.0357142857142857	0.198413881200766	0.999804668915958	1
GO:0005245	voltage-gated calcium channel activity	1/3355	43/18639	0.0232558139534884	0.129199736595848	0.999805287541327	1
GO:0015103	inorganic anion transmembrane transporter activity	14/3355	165/18639	0.0848484848484849	0.471383281398185	0.999834678747542	1
GO:0001217	DNA-binding transcription repressor activity	29/3355	278/18639	0.10431654676259	0.579539825665548	0.999844493508823	1
GO:0001664	G protein-coupled receptor binding	31/3355	297/18639	0.104377104377104	0.579876258862846	0.999900742704546	1
GO:0015081	sodium ion transmembrane transporter activity	13/3355	164/18639	0.0792682926829268	0.440382029006579	0.999931035247328	1
GO:0022824	transmitter-gated monoatomic ion channel activity	2/3355	63/18639	0.0317460317460317	0.176367894400681	0.999945917347473	1
GO:0022835	transmitter-gated channel activity	2/3355	63/18639	0.0317460317460317	0.176367894400681	0.999945917347473	1
GO:0005272	sodium channel activity	1/3355	51/18639	0.0196078431372549	0.10893311124748	0.999960372091133	1
GO:0001216	DNA-binding transcription activator activity	56/3355	491/18639	0.114052953156823	0.633631294751124	0.99998151454828	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/3355	69/18639	0.0289855072463768	0.161031555757144	0.999982174106331	1
GO:0008528	G protein-coupled peptide receptor activity	7/3355	122/18639	0.0573770491803279	0.318763284552051	0.999983026187496	1
GO:0005254	chloride channel activity	3/3355	83/18639	0.036144578313253	0.200804409889932	0.999987517075851	1
GO:0005230	extracellular ligand-gated monoatomic ion channel activity	2/3355	73/18639	0.0273972602739726	0.152207908866341	0.999991528278331	1
GO:0001653	peptide receptor activity	7/3355	128/18639	0.0546875	0.303821255588674	0.999993210744501	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	53/3355	484/18639	0.109504132231405	0.60835991673954	0.999994473801442	1
GO:0015108	chloride transmembrane transporter activity	6/3355	121/18639	0.0495867768595041	0.275483735882056	0.999995592384313	1
GO:0005262	calcium channel activity	7/3355	131/18639	0.0534351145038168	0.29686351691107	0.999995727151028	1
GO:0005126	cytokine receptor binding	24/3355	275/18639	0.0872727272727273	0.484851375152418	0.999996022123356	1
GO:0140375	immune receptor activity	9/3355	156/18639	0.0576923076923077	0.320514731170469	0.99999829706306	1
GO:0030594	neurotransmitter receptor activity	3/3355	97/18639	0.0309278350515464	0.171822330112004	0.999998969066243	1
GO:0005125	cytokine activity	16/3355	234/18639	0.0683760683760684	0.379869311016852	0.999999812157285	1
GO:0046873	metal ion transmembrane transporter activity	43/3355	450/18639	0.0955555555555556	0.530867362146051	0.999999865586018	1
GO:0030527	structural constituent of chromatin	2/3355	98/18639	0.0204081632653061	0.113379360686152	0.999999923358121	1
GO:0099094	ligand-gated monoatomic cation channel activity	5/3355	136/18639	0.0367647058823529	0.204249583589024	0.999999935819689	1
GO:0005244	voltage-gated monoatomic ion channel activity	8/3355	173/18639	0.046242774566474	0.256905834618333	0.999999972903349	1
GO:0022832	voltage-gated channel activity	8/3355	175/18639	0.0457142857142857	0.253969767936981	0.999999980339479	1
GO:0005267	potassium channel activity	3/3355	124/18639	0.0241935483870968	0.134409403394068	0.999999992453492	1
GO:0005249	voltage-gated potassium channel activity	1/3355	98/18639	0.0102040816326531	0.0566896803430761	0.999999996616169	1
GO:0022843	voltage-gated monoatomic cation channel activity	4/3355	143/18639	0.027972027972028	0.155401081779621	0.999999997599386	1
GO:0003823	antigen binding	6/3355	174/18639	0.0344827586206897	0.191572023228326	0.999999999347068	1
GO:0015079	potassium ion transmembrane transporter activity	4/3355	160/18639	0.025	0.138889716840537	0.999999999888811	1
GO:0022834	ligand-gated channel activity	6/3355	188/18639	0.0319148936170213	0.177306021498557	0.999999999942139	1
GO:0015276	ligand-gated monoatomic ion channel activity	5/3355	186/18639	0.0268817204301075	0.149343781548964	0.999999999990129	1
GO:0045182	translation regulator activity	18/3355	356/18639	0.050561797752809	0.280900550913445	0.999999999999949	1
GO:0022836	gated channel activity	14/3355	318/18639	0.0440251572327044	0.244585664876417	0.99999999999996	1
GO:0005261	monoatomic cation channel activity	14/3355	341/18639	0.0410557184750733	0.228088684547509	0.999999999999999	1
GO:0005216	monoatomic ion channel activity	22/3355	448/18639	0.0491071428571429	0.272819086651054	1	1
GO:0030371	translation repressor activity	11/3355	329/18639	0.033434650455927	0.185749165379441	1	1