category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/239	180/9376	5.66657368665737	B2M/IRF7/HLA-B/CASP9/OAS2/IL6/OAS1/HLA-DRB1/TICAM1/TBK1/HLA-A/SRC/NFKBIA/IFNGR1/RELA/IL1B/NECTIN2/PPP1CB/RHEB/HLA-DQA1/SRSF9/OAS3/BST2/IRF9/HLA-C/SOCS3	10.2239254797347
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	22/239	173/9376	4.98880208963165	MX1/RSAD2/IRF7/CASP9/OAS2/MX2/IL6/OAS1/HLA-DRB1/TICAM1/CASP1/TBK1/NFKBIA/IFNGR1/RELA/IL1B/HLA-DQA1/OAS3/MAP2K1/IRF9/NXT1/SOCS3	8.56413698783841
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/239	205/9376	4.21006225125013	B2M/IRF7/HLA-B/CASP9/OAS2/IL6/OAS1/HLA-DRB1/SAP30/CD58/TBK1/VIM/HLA-A/TNFAIP3/NFKBIA/ISG15/RELA/CD44/HLA-DQA1/OAS3/IRF9/HLA-C	7.51562001936758
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	22/239	216/9376	3.99566093289943	IRF7/CASP7/CASP9/IL6/TICAM1/CASP1/TBK1/EIF2AK3/SRC/CCL3L1/NFKBIA/SOD2/HSP90AB1/RELA/TANK/IL1B/ABCG1/OLR1/HSPA8/PPARG/NFATC1/HSPD1	7.20368262443992
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/239	187/9376	4.19573535005482	IRF7/OAS2/IL6/OAS1/RIPK2/TICAM1/CASP1/TBK1/GABARAP/TNFAIP3/NFKBIA/HSP90AB1/RELA/TANK/IL1B/TXN/PRKCD/OAS3/IRF9/NAMPT	7.13904731674568
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/239	156/9376	4.27507778135393	MX1/IFIT1/RSAD2/IRF7/CASP9/OAS2/MX2/OAS1/TICAM1/TBK1/NFKBIA/RELA/OCLN/OAS3/MAP2K1/IRF9/SOCS3	6.67115810687337
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/239	181/9376	3.90133844980235	IL10RB/FCGR3A/IRAK2/CASP9/CEBPB/IL6/HLA-DRB1/RIPK2/SRC/IFNGR1/BCL10/IL10/RELA/IL1B/FCGR2A/HLA-DQA1/CTSS/HSPD1	6.37447746832541
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/239	56/9376	7.00537955768081	CASP7/CASP9/IL6/CASP1/RAB1A/NFKBIA/RELA/IL1B/HSPA8/HSPD1	7.28969394210569
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/239	169/9376	3.94622564432671	CTSL/TP53INP2/HIF1A/TBK1/EIF2AK3/RAB1A/GABARAP/RAB8A/TANK/PRKCD/RHEB/C9orf72/MAP2K1/EPG5/IRS2/DAPK1/UBC	6.25076342487269
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/239	136/9376	4.32685207974403	MX1/IRF7/CASP9/OAS2/MX2/IL6/OAS1/TBK1/TNFAIP3/NFKBIA/RELA/IL1B/HSPA8/OAS3/IRF9	6.32047526779624
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/239	196/9376	3.60276662966442	IRF7/HLA-B/CASP9/IL6/TICAM1/HIF1A/TBK1/GNGT2/HLA-A/SRC/NFKBIA/IFNGR1/RELA/MAP2K1/IRF9/NFATC1/HLA-C/UBC	5.95558875532382
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/239	227/9376	3.28357878826977	B2M/IL10RB/HLA-B/CASP9/IL6/TBK1/GNGT2/ARHGEF11/HLA-A/SRC/CCL3L1/NFKBIA/RELA/IL1B/RHEB/CXCR4/MAP2K1/NFATC1/HLA-C	5.63280726296337
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/239	83/9376	5.199173262086	IRF7/CASP7/IL6/CASP1/TBK1/POLR3E/NFKBIA/RELA/IL1B/ZBP1/POLR2K	6.21452083324381
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/239	238/9376	3.13181674343377	RPS10/MX1/RPL17/RPL36A/RPS21/OAS2/MX2/IL6/OAS1/CASP1/TBK1/C1QC/NFKBIA/ISG15/RELA/IL1B/FCGR2A/OAS3/IRF9	5.38760251218001
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/239	82/9376	4.78416164914787	B2M/HLA-B/CTSL/HLA-DRB1/HLA-A/HSP90AB1/HSPA8/HLA-DQA1/CTSS/HLA-C	5.56619027689733
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/239	138/9376	3.69559153477655	IL6/TICAM1/CASP1/TBK1/SRC/NFKBIA/ARPC1B/IL10/RELA/IL1B/FCGR2A/MAP2K1/NFATC1	5.15926011511352
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/239	142/9376	3.59149036478284	FCGR3A/NFKBIA/IFNGR1/RELA/IL1B/FCGR2A/LILRA6/MAP2K1/IRF9/LILRB4/PPARG/NFATC1/SOCS3	5.03247483380887
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/239	105/9376	4.10982267383941	IL6/CASP1/SRC/NFKBIA/BCL10/IL10/RELA/IL1B/PRKCD/IRF9/NFATC1	5.18262470458106
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/239	109/9376	3.95900349314806	IRF7/IL6/TICAM1/TBK1/CCL3L1/NFKBIA/RELA/IL1B/MAP3K8/MAP2K1/IRF9	5.02541488210914
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/239	44/9376	6.24115633320654	HLA-B/HLA-DRB1/HLA-A/IL1B/HLA-DQA1/HSPD1/HLA-C	5.63571293484316
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/239	45/9376	6.1024639702464	HLA-B/IL6/HLA-DRB1/HLA-A/IL1B/HLA-DQA1/HLA-C	5.54887427934525
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/239	78/9376	4.52655294496299	FCGR3A/HLA-DRB1/NFKBIA/IFNGR1/IL10/RELA/IL1B/FCGR2A/HLA-DQA1	5.05808024514826
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/239	157/9376	3.24835434266983	CASP7/CEBPB/CASP1/HIF1A/C1QC/IL10/ATP11B/DUSP8/MAP2K1/GPR132/PPARG/NFATC1/PPARD	4.59468192997118
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/239	119/9376	3.62631412397595	CASP7/CEBPB/IL6/TNFAIP3/NFKBIA/RELA/IL1B/CCL20/MAP3K8/MAP2K1/SOCS3	4.66302554172288
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/239	66/9376	4.75516673006213	IL6/HLA-DRB1/IFNGR1/IL10/RELA/IL1B/HLA-DQA1/NFATC1	4.95118470427049
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/239	103/9376	3.80875005077792	IL6/TICAM1/CCL3L1/C1QC/NFKBIA/IFNGR1/IL10/RELA/IL1B/GNAL	4.63558289799699
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/239	105/9376	3.7362024307631	RABGEF1/HIF1A/TBK1/EIF2AK3/SRC/GABARAP/CCZ1/RELA/SMURF2/UBC	4.55997392832047
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/239	214/9376	2.74977515348219	B2M/HLA-B/CASP9/TRIM5/TBK1/GNGT2/APOBEC3A/HLA-A/NFKBIA/RELA/CXCR4/BST2/MAP2K1/NFATC1/HLA-C	4.18771159544271
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/239	39/9376	6.03540392661732	HLA-B/HLA-DRB1/HLA-A/IL10/HLA-DQA1/HLA-C	5.0961912113609
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/239	109/9376	3.59909408468005	IL6/HLA-DRB1/HIF1A/NFKBIA/IFNGR1/HSP90AB1/RELA/IL1B/HLA-DQA1/NFATC1	4.41416379649384
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/239	73/9376	4.29919183813836	MX1/MX2/TRIM5/APOBEC3A/ELL/CXCR4/BST2/ELL3	4.57657163962392
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/239	200/9376	2.74610878661088	CASP7/CASP9/IL6/CASP1/TUBB2A/ARHGEF11/SRC/RAB1A/NFKBIA/ARPC1B/RELA/IL1B/FCGR2A/OCLN	4.03684774157327
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	12/239	155/9376	3.03717100823323	FCGR3A/HLA-B/CTSL/HLA-DRB1/TUBB2A/HLA-A/OLR1/FCGR2A/HLA-DQA1/M6PR/CTSS/HLA-C	4.13606258069025
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/239	248/9376	2.53097584019436	CASP7/IL6/RIPK2/CASP1/TUBB2A/NFKBIA/ARPC1B/HSP90AB1/RELA/IL1B/TXN/RHOH/RHOB/ARL8B/MAP2K1/M6PR	3.95174705422559
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/239	94/9376	3.75607584794801	CEBPB/IL6/TBK1/TNFAIP3/NFKBIA/HSP90AB1/RELA/IL1B/CCL20	4.34327258116776
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/239	78/9376	4.02360261774488	CASP7/IL6/TICAM1/CASP1/C1QC/IL10/RELA/IL1B	4.33670638401671
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/239	50/9376	4.70761506276151	IL6/HLA-DRB1/IL15RA/IL10/HLA-DQA1/CXCR4	4.25123106607738
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/239	253/9376	2.32589677013908	UBE2V1/RIPK2/CASP1/TBK1/PPID/SRC/NFKBIA/BCL10/ARPC1B/RELA/IL1B/CD44/PRKCD/HK2/UBC	3.45767294736657
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/239	91/9376	3.44880224378132	IFITM1/NFKBIA/BCL10/RELA/LILRA6/MAP2K1/LILRB4/NFATC1	3.79634989507565
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/239	112/9376	3.15242080095637	IL10RB/CASP9/HLA-DRB1/NFKBIA/IFNGR1/IL10/RELA/HSPA8/HLA-DQA1	3.70612185686133
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/239	157/9376	2.74860752072062	NDUFA7/CASP7/IL6/EIF2AK3/RELA/IL1B/IRS2/PPARG/SREBF1/SOCS3/NDUFB3	3.57341155065725
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/239	72/9376	3.814039981404	IRF7/TBK1/AZI2/NFKBIA/ISG15/RELA/TANK	3.87654149521468
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/239	54/9376	4.35890283589028	HLA-B/HLA-DRB1/HLA-A/IL10/HLA-DQA1/HLA-C	4.00334066340601
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/239	163/9376	2.64743178376158	IRF7/CASP9/IL6/TICAM1/TBK1/SRC/NFKBIA/RELA/MAP2K1/NFATC1/SLC10A1	3.43149589247762
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/239	76/9376	3.61330103501431	ACSL1/OLR1/GK/PPARG/PPARD/SCD/UBC	3.69945320769536
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/239	168/9376	2.56863917114963	CHMP1B/TICAM1/CASP1/PPID/TNFAIP3/IFNGR1/HSP90AB1/IL1B/ZBP1/IRF9/CHMP5	3.31801096981654
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/239	44/9376	4.45796880943325	GTF2B/CCNH/GTF2H2C/TAF12/TAF13	3.71828625376727
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	22/239	480/9376	1.79804741980474	NDUFA7/PSMA2/PSMA6/CASP7/CASP9/IL6/TBK1/EIF2AK3/TUBB2A/PPID/PSMD9/RAB1A/RAB8A/RELA/TANK/IL1B/C9orf72/PSEN1/MAP2K1/GPX2/UBC/NDUFB3	2.90291758083546
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	18/239	368/9376	1.91886483536474	NDUFA7/PSMA2/PSMA6/CASP9/NUP210L/CASP1/TBK1/EIF2AK3/TUBB2A/PSMD9/RAB1A/RAB8A/TANK/C9orf72/NUP205/NXT1/GPX2/NDUFB3	2.90833298133048
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/239	109/9376	2.87927526774404	IL6/NFKBIA/RELA/PPP1CB/PRKCD/IRS2/SREBF1/SOCS3	3.19166162526325
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/239	47/9376	4.17341760883112	CACNA1G/PRKCD/HK2/IRS2/SOCS3	3.52729177677227
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/239	157/9376	2.49873410974602	HLA-B/IL6/PPID/HLA-A/RELA/PPP1CB/RHEB/MAP2K1/NFATC1/HLA-C	3.06277636100029
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/239	110/9376	2.85310003803728	ALDOA/IL6/HIF1A/IFNGR1/RELA/ALDOC/HK2/MAP2K1	3.1617813676555
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/239	90/9376	3.0512319851232	TICAM1/HIF1A/NFKBIA/IFNGR1/RELA/MAP2K1/NFATC1	3.1623102167999
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/239	70/9376	3.36258218768679	HLA-B/CASP9/HLA-DRB1/HLA-A/HLA-DQA1/HLA-C	3.20875972164299
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/239	93/9376	2.95280514689342	HLA-DRB1/NFKBIA/IFNGR1/RELA/HLA-DQA1/NFATC1/MAML1	3.06082842822935
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/239	95/9376	2.89064082801145	CTSL/IL6/HLA-DRB1/CCL3L1/IL1B/CCL20/HLA-DQA1	2.99540965075989
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	14/239	275/9376	1.99717002662609	NDUFA7/PSMA2/PSMA6/CASP9/IL6/EIF2AK3/TUBB2A/PSMD9/C1QC/IL1B/PRKCD/HSPA8/STIP1/NDUFB3	2.7143995945311
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	16/239	333/9376	1.88493095606066	OASL/MX1/HLA-B/MX2/TICAM1/TBK1/HLA-A/HES4/ISG15/RELA/RHEB/PSEN1/MAP2K1/IRF9/HLA-C/MAML1	2.65924294126383
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/239	144/9376	2.45188284518828	IL6/TICAM1/TBK1/C1QC/NFKBIA/RELA/IL1B/SREBF1/SCD	2.83953808641159
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/239	224/9376	2.10161386730424	B2M/HLA-B/IL6/HLA-DRB1/IL15RA/HLA-A/NFKBIA/RELA/HLA-DQA1/MAP2K1/NFATC1/HLA-C	2.69884643572382
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/239	99/9376	2.77384725920291	DEFB1/FCGR3A/HLA-DRB1/C1QC/IL10/FCGR2A/HLA-DQA1	2.86954352513734
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/239	100/9376	2.74610878661088	IL10RB/ACKR3/IL6/CCL3L1/IL10/CCL20/CXCR4	2.83905433293144
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/239	160/9376	2.20669456066946	HLA-B/HLA-DRB1/CD58/HLA-A/NECTIN2/PDCD1LG2/HLA-DQA1/OCLN/HLA-C	2.48982538002657
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/239	137/9376	2.29081024951898	CASP7/CASP9/CTSL/EIF2AK3/NFKBIA/RELA/MAP2K1/CTSS	2.4614611267032
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/239	138/9376	2.2742101752471	PHKG1/PPP1CB/HK2/RHEB/MAP2K1/IRS2/SREBF1/SOCS3	2.43879002089579
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	12/239	250/9376	1.8830460251046	HLA-B/CHMP1B/HLA-A/SRC/SNX3/RAB8A/ARPC1B/SMURF2/HSPA8/CXCR4/HLA-C/CHMP5	2.28873698824451
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/239	27/9376	4.35890283589028	ACOT2/ELOVL5/SCD	2.8266987017992
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/239	70/9376	2.80215182307232	ACSL1/NFKBIA/RELA/IRS2/SOCS3	2.44760678053778
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/239	120/9376	2.2884239888424	IRAK2/RIPK2/NFKBIA/RELA/PRKCD/PSEN1/MAP2K1	2.29731489555981
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/239	174/9376	2.0291444236041	HSPH1/HSPA4L/EIF2AK3/DNAJA1/EDEM1/HSP90AB1/HSPA8/DNAJB11/ERO1B	2.21611662142109
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/239	122/9376	2.25090884148433	NFKBIA/BCL10/IL10/RELA/MAP3K8/MAP2K1/NFATC1	2.24917685673952
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/239	205/9376	1.91366465965915	IRF7/HLA-B/GTF2B/HLA-A/SRC/GTF2H2C/NFKBIA/RELA/IRF9/HLA-C	2.13913496675922
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/239	388/9376	1.61773713496959	NDUFA7/PSMA2/PSMA6/CASP7/CASP9/IL6/EIF2AK3/TUBB2A/PPID/PSMD9/RELA/IL1B/PSEN1/MAP2K1/IRS2/NDUFB3	2.00988318424002
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/239	30/9376	3.92301255230126	IL6/RELA/IL1B	2.59335037160402
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/239	99/9376	2.37758336503106	HIF1A/GPCPD1/CHKB/RHEB/MAP2K1/SLC22A5	2.2285094756344
Human Diseases	Immune disease	hsa05310	Asthma	3/239	32/9376	3.67782426778243	HLA-DRB1/IL10/HLA-DQA1	2.45399358742441
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/239	78/9376	2.51475163609055	TOB1/BTG3/MPHOSPH6/PAN3/HSPD1	2.17258480062208
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/239	105/9376	2.24172145845786	TICAM1/TNFAIP3/NFKBIA/BCL10/RELA/IL1B	2.06937082327815
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/239	133/9376	2.06474344857961	FCGR3A/HLA-B/HLA-A/IFNGR1/MAP2K1/NFATC1/HLA-C	2.00007875473801
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/239	193/9376	1.8293840917467	GNGT2/SRC/CCL3L1/NFKBIA/RELA/CCL20/PRKCD/CXCR4/MAP2K1	1.882889525874
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/239	35/9376	3.36258218768679	ALDOA/ALDOC/HK2	2.26468100622644
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/239	37/9376	3.18082098835237	HK2/TGDS/GALK2	2.149579287415
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/239	37/9376	3.18082098835237	IL6/IL10/IL1B	2.149579287415
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/239	37/9376	3.18082098835237	MAP2K1/PPARG/TFG	2.149579287415
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/239	38/9376	3.09711517286941	GNPDA2/HK2/GALK2	2.09493195907795
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/239	90/9376	2.17945141794514	SOD2/RELA/RHEB/IRS2/PPARG	1.81831762386595
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	11/239	268/9376	1.61019171922813	NDUFA7/PSMA2/PSMA6/CASP9/EIF2AK3/TUBB2A/PSMD9/TXN/GNAL/UBC/NDUFB3	1.63909819446359
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/239	41/9376	2.87049698948872	SRC/MAP2K1/DAPK1	1.94121910545643
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/239	122/9376	1.92935043555799	RAB8A/RHEB/IRS2/PPARG/SREBF1/SCD	1.67100385107001
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	12/239	308/9376	1.52844644894854	NDUFA7/PSMA2/PSMA6/CASP9/TUBB2A/PSMD9/SOD2/NRF1/POLR2K/PPARG/GPX2/NDUFB3	1.52511770434855
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/239	98/9376	2.00153701648023	FCGR3A/ARPC1B/FCGR2A/PRKCD/MAP2K1	1.61189086961788
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/239	71/9376	2.21014791678944	SRC/RELA/MAP2K1/SOCS3	1.65535909526829
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/239	71/9376	2.21014791678944	SLC7A5/HIF1A/HK2/MAP2K1	1.65535909526829
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/239	100/9376	1.96150627615063	IL6/HLA-DRB1/IL1B/CD44/HLA-DQA1	1.56334392242798
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/239	46/9376	2.55848644715299	PSMA2/PSMA6/PSMD9	1.71365700316946
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/239	101/9376	1.94208542193131	IL6/RELA/IL1B/PRKCD/NFATC1	1.5394896994321
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/239	103/9376	1.90437502538896	IL6/IL10/RELA/IL1B/GNAL	1.49258756574211
NA	NA	hsa03272	Virion - Hepatitis viruses	3/239	48/9376	2.45188284518828	CHMP1B/OCLN/SLC10A1	1.63095019886203
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/239	75/9376	2.09227336122734	ALDOA/ALDOC/SDSL/SDS	1.53596007772327
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/239	133/9376	1.76978009878252	IL6/GABARAP/SOD2/IL10/MAP2K1/IRS2	1.44600168561632
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/239	227/9376	1.55537942602252	NDUFA7/HIF1A/SRC/NFKBIA/SOD2/RELA/PRKCD/MAP2K1/NDUFB3	1.36993095253367
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/239	106/9376	1.85047761901003	CASP9/NFKBIA/HSP90AB1/RELA/MAP2K1	1.42415982745435
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/239	50/9376	2.35380753138075	IL6/IL10/IL1B	1.55230479363968
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/239	168/9376	1.63458856345886	IL10RB/IL6/IL15RA/IFNGR1/IL10/IRF9/SOCS3	1.34229200290432
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/239	298/9376	1.44809188172194	IL10RB/ACKR3/IL6/IL15RA/CCL3L1/IFNGR1/IL10/IL1B/CCL20/TNFSF9/CXCR4	1.27134346418863
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/239	108/9376	1.81620951495428	NUP210L/THOC3/NUP205/THOC1/NXT1	1.37975918762276
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/239	139/9376	1.69338671322356	FKBP4/SRC/HSP90AB1/PRKCD/HSPA8/MAP2K1	1.33198771681139
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/239	204/9376	1.5384362950201	PLAUR/DDX5/CTSL/HIF1A/SRC/PPP1CB/CD44/MAP2K1	1.25747732954806
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/239	142/9376	1.65761093759208	CTSL/SRC/HSP90AB1/RELA/IL1B/TXN	1.27702982764009
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/239	143/9376	1.64601925271381	FCGR3A/HLA-DRB1/C1QC/IL10/FCGR2A/HLA-DQA1	1.25899741450276
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/239	28/9376	2.80215182307232	ACOT2/ELOVL5	1.54452099289699
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/239	28/9376	2.80215182307232	GCH1/PTS	1.54452099289699
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/239	116/9376	1.69095368633675	ALDOA/ALDOC/HK2/SDSL/SDS	1.21103087541078
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/239	57/9376	2.06474344857961	ACSL1/ELOVL5/SCD	1.30400880750026
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/239	31/9376	2.53097584019436	ALDOA/ALDOC	1.38083665655496
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/239	32/9376	2.45188284518828	CASP7/CASP9	1.33052464818167
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/239	60/9376	1.96150627615063	CASP9/SRC/MAP2K1	1.20835845404611
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/239	122/9376	1.60779202963166	CASP9/HIF1A/SRC/RHEB/MAP2K1	1.0928308454005
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/239	62/9376	1.89823188014577	SOD2/HSPA8/IRS2	1.14762227504567
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/239	93/9376	1.68731722679624	SNAI1/SRC/SMURF2/NECTIN2	1.07730159884944
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/239	93/9376	1.68731722679624	CASP9/CKS2/NFKBIA/RELA	1.07730159884944
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/239	34/9376	2.30765444253015	POLR3E/POLR2K	1.23536501130687
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/239	34/9376	2.30765444253015	NFIL3/BHLHE40	1.23536501130687
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/239	63/9376	1.86810121538155	CCNH/GTF2H2C/POLR2K	1.1180947640752
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/239	300/9376	1.30767085076708	CACNA1G/EREG/RELA/IL1B/HSPA8/MAP3K8/DUSP8/MAP2K1/NFATC1/DUSP10	0.875956445074669
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/239	130/9376	1.50885098165433	GNGT2/SRC/NFKBIA/RELA/MAP2K1	0.944861437385851
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/239	67/9376	1.7565727846125	ALDOA/ALDOC/HK2	1.00512338483072
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/239	99/9376	1.58505557668738	SRC/IL1B/PPP1CB/PRKCD	0.946441376628534
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/239	68/9376	1.73074083189761	RELA/MAP2K1/PPARD	0.978075590571456
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/239	134/9376	1.46381065384375	ARHGEF11/PPP1CB/PRKCD/MAP2K1/ADM2	0.874566652571774
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/239	39/9376	2.01180130887244	MTHFS/MTHFD1L	1.02401575187695
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/239	71/9376	1.65761093759208	SRC/NFKBIA/RELA	0.899544784226875
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/239	41/9376	1.91366465965915	SDSL/SDS	0.948209648707046
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/239	42/9376	1.86810121538155	KYNU/AADAT	0.911893011478304
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/239	42/9376	1.86810121538155	ACSL1/SAT1	0.911893011478304
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/239	110/9376	1.42655001901864	NRROS/SMAD6/SMURF2/SKI	0.727784725499585
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/239	77/9376	1.52844644894854	CASP9/RELA/MAP2K1	0.753027781285735
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/239	77/9376	1.52844644894854	NFKBIA/RELA/MAP2K1	0.753027781285735
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/239	45/9376	1.74356113435611	DEFB1/ABCG1	0.808614676675546
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/239	80/9376	1.47112970711297	IL6/SRC/MAP2K1	0.684416075660037
Genetic Information Processing	Translation	hsa03010	Ribosome	7/239	222/9376	1.23698593991481	RPS10/RPL17/RPL36A/RPS21/MRPL53/MRPS28/MRPL32	0.577931531669442
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/239	154/9376	1.27370537412378	GCH1/CMPK2/KYNU/MTHFD1L/PTS	0.553877728468181
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/239	50/9376	1.5692050209205	P4HA1/SAT1	0.652662702827119
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/239	85/9376	1.38459266551809	GMPR/CMPK2/NT5C3A	0.576052421652033
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/239	18/9376	2.17945141794514	ACSL1	0.810042052053597
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/239	18/9376	2.17945141794514	TCN2	0.810042052053597
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/239	86/9376	1.36849275080276	EREG/SRC/MAP2K1	0.555204648250922
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/239	195/9376	1.20708078532346	FCGR3A/CASP1/SRC/RELA/FCGR2A/MAP2K1	0.472601277787825
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/239	87/9376	1.3527629490694	CASP9/EREG/MAP2K1	0.534614687153992
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/239	235/9376	1.16855693047271	NDUFA7/ACSL1/RHEB/PPARG/COA6/COX16/NDUFB3	0.423220276684251
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/239	89/9376	1.32236378167458	TUBB2A/SRC/MAP2K1	0.494181289898773
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/239	89/9376	1.32236378167458	GNGT2/SRC/GABARAP	0.494181289898773
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/239	54/9376	1.45296761196343	SDSL/SDS	0.539873806649862
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/239	20/9376	1.96150627615063	CYP51A1	0.696153147246059
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/239	20/9376	1.96150627615063	TGDS	0.696153147246059
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/239	21/9376	1.86810121538155	DSE	0.644081599153622
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/239	93/9376	1.26548792009718	SRC/PRKCD/MAP2K1	0.416125989056131
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/239	59/9376	1.32983476349195	CMPK2/NT5C3A	0.411023980899903
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/239	59/9376	1.32983476349195	CASP9/MAP2K1	0.411023980899903
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/239	23/9376	1.70565763143533	FUT4	0.547980708682636
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/239	24/9376	1.63458856345886	HS3ST3B1	0.503417593189029
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/239	62/9376	1.26548792009718	PSEN1/MAML1	0.339199551467292
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/239	217/9376	1.08470393151187	SRC/HSP90AB1/RELA/PTGES3/KLF4/MAP2K1	0.204170119090829
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/239	26/9376	1.50885098165433	TCN2	0.420198271360755
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/239	103/9376	1.14262501523338	DAZAP1/PPP1CB/NXT1	0.235389432840164
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/239	65/9376	1.20708078532346	MOGAT1/GK	0.270944971017202
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/239	65/9376	1.20708078532346	CACNA1G/MAP2K1	0.270944971017202
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/239	104/9376	1.13163823624075	GPCPD1/CHKB/SELENOI	0.218320636661008
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/239	144/9376	1.08972570897257	PSMA2/PSMA6/GTF2B/PSMD9	0.1754821808125
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/239	184/9376	1.06603601964708	SEMA6B/SRC/CXCR4/SEMA4B/SRGAP2	0.146307829642176
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/239	67/9376	1.171048523075	PPP1CB/MAP2K1	0.227241679822644
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/239	28/9376	1.40107591153616	FUT4	0.343739166246728
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/239	226/9376	1.04150775724812	NFKBIA/RELA/PDE4B/PPP1CB/MAP2K1/NFATC1	0.102154080007019
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/239	70/9376	1.12086072922893	HIF1A/MAP2K1	0.164147957222136
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/239	31/9376	1.26548792009718	SRP19	0.239452147001992
NA	NA	hsa04981	Folate transport and metabolism	1/239	31/9376	1.26548792009718	MTHFS	0.239452147001992
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/239	154/9376	1.01896429929903	SRC/PPP1CB/MAP2K1/NFATC1	0.0383766780296596
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/239	73/9376	1.07479795953459	CASP9/MAP2K1	0.103758204160963
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/239	32/9376	1.22594142259414	HK2	0.207055708938934
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/239	32/9376	1.22594142259414	GABARAP	0.207055708938934
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/239	115/9376	1.0233945788612	ARHGEF11/PDE4B/MAP2K1	0.040824228478098
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/239	116/9376	1.01457221180205	RHOH/OCLN/CXCR4	0.0255406386336372
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/239	33/9376	1.18879168251553	AADAT	0.175703101887472
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/239	33/9376	1.18879168251553	STX11	0.175703101887472
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/239	158/9376	0.993167734759811	SLC7A5/TBC1D7/RHEB/MAP2K1	-0.0140074050049169
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/239	201/9376	0.975873769229168	DDX5/CEBPB/IL6/RELA/PPARG	-0.0559200107287928
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/239	243/9376	0.968645074642285	DDX5/PHF5A/THOC3/HSPA8/SRSF9/THOC1	-0.080091228534943
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/239	78/9376	1.00590065443622	SRC/ARPC1B	0.00846321722743917
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	5/239	205/9376	0.956832329829574	NDUFA7/RELA/PPP1CB/PRKCD/NDUFB3	-0.101067138494264
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/239	122/9376	0.964675217778997	MAP2K1/IRS2/SOCS3	-0.0635151659385235
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/239	36/9376	1.08972570897257	HK2	0.0872323328820983
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/239	36/9376	1.08972570897257	GCNT3	0.0872323328820983
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/239	166/9376	0.945304229470182	PPP1CB/MAP2K1/IRS2/NFATC1	-0.11499017899442
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/239	125/9376	0.941523012552301	RELA/MAP2K1/ACER2	-0.10644577622169
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/239	38/9376	1.0323717242898	NAMPT	0.0323380235203673
Organismal Systems	Immune system	hsa04611	Platelet activation	3/239	126/9376	0.934050607690775	SRC/FCGR2A/PPP1CB	-0.120533559087971
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/239	83/9376	0.945304229470182	ACSL1/SOD2	-0.0809464111702366
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/239	170/9376	0.92306177701206	SRC/RAB8A/ARPC1B/OCLN	-0.163724586774987
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/239	41/9376	0.956832329829574	UIMC1	-0.0447998080423413
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/239	88/9376	0.891593761886649	PLAUR/C1QC	-0.165240797686183
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/239	133/9376	0.884890049391261	GNGT2/PPP1CB/GNAL	-0.216229521748748
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/239	178/9376	0.88157585444972	CACYBP/PSEN1/NFATC1/PPARD	-0.257980175972337
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/239	43/9376	0.912328500535176	ACSL1	-0.0931890330765259
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/239	91/9376	0.862200560945331	GNGT2/PDE4B	-0.213628882170933
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/239	138/9376	0.852828815717664	PPP1CB/MAP2K1/REC8	-0.281680073321947
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/239	140/9376	0.840645546921698	GNGT2/NRF1/MAP2K1	-0.307233830855605
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/239	142/9376	0.82880546879604	SMURF2/SOCS3/UBC	-0.332446603575094
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/239	232/9376	0.845476843168374	SRC/ARPC1B/PPP1CB/CXCR4/MAP2K1	-0.385435961237041
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/239	362/9376	0.866964099956078	CASP9/IL6/EREG/GNGT2/HSP90AB1/RELA/RHEB/MAP2K1	-0.417491018345304
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/239	48/9376	0.817294281729428	AUH	-0.205239650385136
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/239	48/9376	0.817294281729428	HK2	-0.205239650385136
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/239	97/9376	0.808868567484795	CACNA1G/GNGT2	-0.306020253664342
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/239	144/9376	0.817294281729428	HESX1/KLF4/MAP2K1	-0.357329000307319
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/239	49/9376	0.800614806592093	RELA	-0.226309472206764
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/239	99/9376	0.792527788343688	SRC/MAP2K1	-0.335626722377337
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/239	51/9376	0.76921814751005	SELENOI	-0.26726685248863
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/239	149/9376	0.789868299121058	NDUFA7/GNGT2/NDUFB3	-0.418154934377745
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/239	52/9376	0.754425490827164	ACOT2	-0.2871882057418
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/239	55/9376	0.713275009509319	ACER2	-0.344904145244845
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/239	107/9376	0.733273374261917	SIK1/PHKG1	-0.448770803912824
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/239	56/9376	0.700537955768081	SMURF2	-0.363505192096641
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/239	250/9376	0.784602510460251	CTSL/OSTM1/ARL8B/M6PR/CTSS	-0.558281434341132
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/239	110/9376	0.713275009509319	HSP90AB1/MAP2K1	-0.489213595578373
NA	NA	hsa04517	IgSF CAM signaling	6/239	299/9376	0.787226599123998	TUBB2A/SRC/ARPC1B/NECTIN2/MAP2K1/SRGAP2	-0.604734210545902
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/239	254/9376	0.772246565413633	CACNA1G/PHKG1/CXCR4/NFATC1/GNAL	-0.59514054116732
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/239	59/9376	0.664917381745975	GPX2	-0.417563601322735
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/239	59/9376	0.664917381745975	IRS2	-0.417563601322735
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/239	60/9376	0.653835425383542	MAP2K1	-0.435037087749122
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/239	115/9376	0.682263052574131	GNGT2/MAP2K1	-0.554460322393825
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/239	115/9376	0.682263052574131	GNGT2/MAP2K1	-0.554460322393825
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/239	63/9376	0.622700405127183	AADAT	-0.485953358940495
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/239	63/9376	0.622700405127183	PTGES3	-0.485953358940495
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/239	65/9376	0.603540392661732	CACNA1G	-0.518728652935948
NA	NA	hsa04519	Cadherin signaling	8/239	404/9376	0.776834168772526	VIM/NFKBIA/ARPC1B/RELA/PPP1CB/PSEN1/MAP2K1/SCN3B	-0.74157747030028
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/239	69/9376	0.568552543811776	MAP2K1	-0.581741943333978
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/239	69/9376	0.568552543811776	PPP1CB	-0.581741943333978
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/239	128/9376	0.612970711297071	GMPR/PDE4B	-0.713029802271834
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/239	73/9376	0.537398979767295	MAP2K1	-0.64171070174953
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/239	75/9376	0.523068340306834	CASP9	-0.670663604088881
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/239	75/9376	0.523068340306834	CASP9	-0.670663604088881
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/239	75/9376	0.523068340306834	GPX2	-0.670663604088881
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/239	76/9376	0.516185862144902	MAP2K1	-0.684899190807004
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/239	238/9376	0.6593298407229	TBK1/GNGT2/RELA/MAP2K1	-0.860953649791561
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/239	191/9376	0.616179982036846	GNGT2/PPP1CB/MAP2K1	-0.866737328216648
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/239	138/9376	0.568552543811776	NDUFA7/NDUFB3	-0.825774092165494
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/239	82/9376	0.478416164914787	CES1	-0.767206885068425
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/239	83/9376	0.472652114735091	PHF1	-0.780442771660686
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/239	86/9376	0.456164250267588	PKD2L1	-0.819392336697756
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	3/239	203/9376	0.579755549601171	SRC/PPP1CB/MAP2K1	-0.978987362020903
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/239	149/9376	0.526578866080705	RHEB/MAP2K1	-0.9420919469029
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/239	89/9376	0.44078792722486	CD44	-0.857267966070572
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/239	90/9376	0.435890283589028	SLC10A1	-0.86966756200195
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/239	154/9376	0.509482149649514	PPP1CB/CREM	-0.992625422847384
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/239	155/9376	0.506195168038872	CACNA1G/MAP2K1	-1.00257056446615
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/239	98/9376	0.400307403296046	CACNA1G	-0.965155561200987
NA	NA	hsa04081	Hormone signaling	3/239	219/9376	0.537398979767295	GNGT2/SRC/IRS2	-1.12030122998036
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/239	99/9376	0.396263894171844	IL6	-0.976660771880272
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/239	101/9376	0.388417084386263	MAP2K1	-0.999405761959282
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/239	102/9376	0.384609073755025	RAB8A	-1.01064912594489
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/239	103/9376	0.380875005077792	COL8A1	-1.02180870006179
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/239	116/9376	0.33819073726735	GNGT2	-1.1599495981435
NA	NA	hsa04082	Neuroactive ligand signaling	2/239	199/9376	0.394272618321734	GNGT2/GNAL	-1.39680620234405
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/239	323/9376	0.485821987901084	VIM/CD44/MAP2K1/IRS2	-1.5209021648803
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/239	212/9376	0.370095523802005	SRC/MAP2K1	-1.50031641509547
NA	NA	hsa04382	Cornified envelope formation	2/239	217/9376	0.361567977170623	OCLN/TGM1	-1.53887475830103
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/239	148/9376	0.265068415696031	MAP2K1	-1.45749392398242
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/239	150/9376	0.261534170153417	MAP2K1	-1.47452481287028
NA	NA	hsa04518	Integrin signaling	1/239	154/9376	0.254741074824757	SRC	-1.50812647328591
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/239	157/9376	0.249873410974602	PPP1CB	-1.53294034591239
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/239	158/9376	0.248291933689953	CCNH	-1.5411403041456
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/239	170/9376	0.230765444253015	MAP2K1	-1.63693161710347
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/239	183/9376	0.214372270617555	NXT1	-1.73578725347234
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/239	194/9376	0.202217141871199	TUBB2A	-1.81593248358346
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/239	233/9376	0.168369637437822	VIM	-2.07896277804871
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/239	449/9376	0.174744434400947	GNAL/OR2F1	-2.8982886845464
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/239	370/9376	0.106027366278412	ADM2	-2.83753933976932