category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/563	173/9376	2.79165083830429	MX1/HLA-DQA2/IRF7/MX2/IRF9/IFNGR2/NUP98/TNFRSF10A/EIF2AK2/RSAD2/STAT2/TRIM25/MAP2K1/NXT1/TBK1/TNFRSF10B/CXCL8/NXF1/CCND3/PML/OAS2/PABPN1/IFIH1/KPNA1/CASP1/OAS3/CHUK/OAS1/EP300	6.01159435849334
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/563	68/9376	3.91850381360359	RUNX1/FCGR1A/KRAS/BCL2A1/MAP2K1/ITGAM/RARA/STAT3/PML/DUSP6/BRAF/PPARD/PIM1/CHUK/ZBTB16/CEBPA	6.10470222437544
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	26/563	157/9376	2.75792784333247	ATP11B/HIF1A/CPT1A/HAVCR2/SIGLEC10/ABCA1/ATP2A3/ADAM17/MAP2K1/ADAM9/CEBPB/SIRPA/ANO5/ALOX5/RAB5A/IL10/SGK1/CRK/PPARD/ARNT/DUSP8/CX3CL1/CASP1/ATP2A2/ITGAV/SPHK1	5.61418751604693
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	27/563	180/9376	2.49804618117229	HLA-DQA2/IRF7/IRF9/IFNGR2/SP100/ZC3HAV1/ITGA5/EIF2AK2/STAT2/PILRA/BIRC2/TLR2/TBK1/TAP1/NXF1/PILRB/IRAK1/B2M/NECTIN2/PML/OAS2/PPP1CB/IFIH1/OAS3/CHUK/OAS1/SRSF4	5.12908532269422
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/563	98/9376	2.88889694421285	ARPC1B/PLCG2/GAB2/DNM2/FCGR1A/FCGR2A/MAP2K1/PRKCD/ARPC1A/VASP/MARCKSL1/CRK/VAV3/WASF1/SPHK1/LIMK1/ACTR3	4.75085820238353
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/563	248/9376	2.08170515097691	ARPC1B/NAIP/PLEKHM1/DNM2/TNFRSF10A/PIK3C2A/MAP2K1/CTNNB1/ARPC1A/TAB3/BIRC2/TLR2/ABI1/TNFRSF10B/ARL8A/CXCL8/IRAK1/DYNLT1/CYTH3/RAB5A/DCTN4/CYTH1/TLR6/MLKL/KPNA1/RAB9B/CASP1/CHUK/ARL8B/ACTR3/SNX18	4.36339845031815
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/563	73/9376	3.19384899875909	MX1/MAP1S/ELL2/MX2/ELL/CDK9/RANBP2/KAT2B/TRIM5/CHMP4B/HGS/PDCD6IP/EP300/CCNT2	4.75592067369194
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/563	138/9376	2.41357118953845	ARPC1B/WIPF2/ITGA5/LCP2/FCGR2A/MAP2K1/ARPC1A/TBK1/MEFV/CXCL8/IRAK1/WIPF1/IL10/ITGB1/CRK/VAV3/CASP1/CHUK/LIMK1/ACTR3	4.22810924411692
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	29/563	238/9376	2.02922518918758	MX1/RPL36A/RPS10/RPL17/PLCG2/MX2/IRF9/RPS21/EIF2AK2/STAT2/FCGR2A/ADAM17/C3AR1/RPS17/TLR2/TBK1/CXCL8/IRAK1/STAT3/IL6R/RPL39/MAS1/OAS2/IFIH1/CASP1/OAS3/CHUK/TLR8/OAS1	4.06491303582793
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/563	70/9376	3.09281908145141	HIF1A/KRAS/MAP2K1/PRCC/RAPGEF1/ELOC/BRAF/CRK/ARNT/TFE3/VEGFA/RAP1A/EP300	4.44198546222241
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/563	156/9376	2.24183631643667	MX1/IRF7/MX2/IFIT1/IRF9/KRAS/EIF2AK2/RSAD2/STAT2/MAP2K1/CTNNB1/YWHAH/TBK1/PPP2CA/STAT3/OAS2/BRAF/OAS3/CHUK/RB1/OAS1	3.95311224106639
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/563	136/9376	2.32661163932713	MX1/IRF7/MX2/IRF9/EIF2AK2/STAT2/HSPA6/TLR2/TBK1/JAK3/CCND3/IRAK1/STAT3/OAS2/IFIH1/RAB9B/OAS3/CHUK/OAS1	3.93872103561829
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	29/563	253/9376	1.90891539536223	ARPC1B/UBE2V1/NAIP/PLCG2/ITGA5/PRKCD/ARPC1A/TAB3/MAP1LC3B/CD44/TBK1/FBXW11/ACTN1/CXCL8/CYTH3/CUL1/UBE2D1/ITGB1/CRK/CYTH1/HK1/CASP1/UBE2N/WASF1/CHUK/MDM2/ACTR3/FNBP1/HK3	3.7041864040494
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/563	187/9376	2.04830881165642	GABARAP/IRF7/NAIP/IRF9/STAT2/PRKCD/TAB3/BIRC2/MAP1LC3B/TBK1/MEFV/NOD2/CXCL8/GBP5/OAS2/GABARAPL2/NLRP12/CASP1/CXCL1/OAS3/CHUK/OAS1/CARD8	3.65977060317235
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/563	110/9376	2.42234781204586	ALDOA/HIF1A/PLCG2/IFNGR2/EIF4E/MAP2K1/STAT3/IL6R/ELOC/PFKFB3/ARNT/HK1/MKNK2/VEGFA/HK3/EP300	3.79257304668859
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/563	155/9376	2.14885693004068	HLA-DQA2/FCGR1A/STX12/ITGA5/FCGR2A/CLEC7A/ITGAM/OLR1/TLR2/TAP1/SEC22B/SEC61G/RAB5A/ITGB1/TLR6/HGS/SEC61B/MARCO/ITGAV/ATP6V1B2	3.6451947569938
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/563	205/9376	1.94969458042715	HLA-DQA2/IRF7/PLCG2/CD58/SAP30/IRF9/NCOR2/EIF2AK2/STAT2/CD44/TLR2/TBK1/JAK3/TAP1/CCND3/IRAK1/STAT3/B2M/OAS2/OAS3/CHUK/MDM2/RB1/OAS1	3.47480545009013
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	23/563	196/9376	1.95425381520281	HIF1A/IRF7/GNG10/PLCG2/IRF9/KRAS/EIF2AK2/STAT2/MAP2K1/CTNNB1/MAP1LC3B/TBK1/PIK3R5/CXCL8/STAT3/PREX1/CLEC2B/ATG3/CXCL1/CHUK/RB1/VEGFA/EP300	3.4123105636926
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/563	56/9376	2.97386450139558	NAIP/ITGAM/RAB1A/HSPA6/TLR2/CXCL8/SEC22B/BCL2L13/CASP1/CXCL1	3.74439230887323
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/563	142/9376	2.11102494183574	CUL3/BIRC2/UBA6/SMURF2/FBXW11/PML/UBE2H/CUL1/UBE2D1/ELOC/UBE2W/UBR5/UBE2N/MDM2/SYVN1/UBE2S/UBE2E3/UBE2A	3.37171607394016
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/563	201/9376	1.90564053621767	RUNX1/FCGR1A/CDK14/CDK9/BCL2A1/KDM6A/CEBPB/ITGAM/ETV6/BIRC2/SS18L1/PRCC/RARA/CXCL8/BCL6/PML/DUSP6/ID2/TFE3/ZBTB16/MDM2/CEBPA/CCNT2	3.2804150522051
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/563	41/9376	3.24949096737859	KRAS/MAP2K1/CXCL8/DAPK1/BRAF/MDM2/RB1/VEGFA	3.64835400082502
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	20/563	169/9376	1.97084511335092	GABARAP/HIF1A/IRS2/PLEKHM1/KRAS/MAP2K1/PRKCD/NRBF2/ERN1/MAP1LC3B/MTMR3/RAB1A/TBK1/EIF2AK3/PPP2CA/WDFY3/DAPK1/GABARAPL2/WDR45B/ATG3	3.21893480147002
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/563	62/9376	2.68607116255085	NCOR2/ADAM17/MAML2/KAT2B/TLE3/TLE4/NCSTN/ATXN1/JAG1/EP300	3.36652294713565
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/563	174/9376	1.91421163308222	ERN1/SEC24A/ERO1B/HSPA6/UBQLN1/DNAJB11/KRTCAP2/PDIA4/EIF2AK3/SEC61G/CUL1/STT3B/UBE2D1/HYOU1/SELENOS/SEC61B/XBP1/HSPH1/DERL2/SYVN1	3.07650909630607
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/563	105/9376	2.22048549437537	GABARAP/HIF1A/RABGEF1/KRAS/MAP1LC3B/SMURF2/TBK1/EIF2AK3/BCL2L13/RAB5A/GABARAPL2/TOMM40L/TFE3/OPA1	3.17864429959518
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/563	216/9376	1.77330438786922	IRF7/ABCA1/KRAS/TNFRSF10A/ERN1/OLR1/HSPA6/TLR2/TBK1/EIF2AK3/TNFRSF10B/CXCL8/IRAK1/STAT3/TICAM2/VAV3/TLR6/CASP1/CXCL1/XBP1/CHUK/RAP1A/MIB2	2.90607998767377
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/563	109/9376	2.13899978815976	MAP3K8/IRF7/TLR1/IRF9/STAT2/MAP2K1/TLR2/TBK1/CXCL8/IRAK1/TICAM2/TLR6/CHUK/TLR8	3.02304951998822
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/563	133/9376	2.00344555883492	GABARAP/IRS2/KRAS/MAP2K1/BCL6/STAT3/IL10/SGK1/BRAF/GABARAPL2/TPTEP2-CSNK1E/HOMER3/CHUK/PLK3/MDM2/EP300	2.94571760076801
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/563	78/9376	2.34859042674318	HLA-DQA2/IFNGR2/FCGR1A/FCGR2A/ITGAM/TLR2/ELK1/MARCKSL1/IRAK1/IL10/ITGB1	3.0228079337258
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/563	200/9376	1.7486323268206	ARPC1B/NAIP/WIPF2/TNFRSF10A/FCGR2A/SEC24A/ARPC1A/TAB3/RAB1A/ABI1/TNFRSF10B/CXCL8/IRAK1/WIPF1/CYTH3/ITGB1/CYTH1/CASP1/WASF1/CHUK/ACTR3	2.704797911865
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/563	163/9376	1.83905240331702	IRF7/KRAS/STAT2/MAP2K1/TLR2/TBK1/ELK1/JAK3/CXCL8/IRAK1/STAT3/TICAM2/BRAF/IFIH1/CHUK/CREB5/RB1/EP300	2.73124275869706
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/563	71/9376	2.34558326870638	HIF1A/KRAS/SLC7A5/MAP2K1/SLC16A3/TIGAR/GLS/HK1/SIRT6/HK3	2.87646778534539
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/563	204/9376	1.71434541845157	HIF1A/PLCG2/HPSE/KRAS/ITGA5/MAP2K1/CTNNB1/CD44/TLR2/ELK1/STAT3/ITGB1/BRAF/VAV3/PPP1CB/PPP1R12C/HOXD10/ITGAV/MDM2/WNT11/VEGFA	2.60716954821012
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/563	142/9376	1.8764666149651	LILRB1/PLCG2/GAB2/IRF9/IFNGR2/FCGR1A/LCP2/LILRA1/STAT2/FCGR2A/ATP2A3/MAP2K1/SIRPA/OSCAR/ATP2A2/CHUK	2.65988319674165
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/563	181/9376	1.74817228148337	HLA-DQA2/TLR1/IFNGR2/FCGR1A/FCGR2A/CLEC7A/CEBPB/ITGAM/TLR2/NOD2/IRAK1/RAB5A/IL10/IRAK2/VDR/TLR6/PLK3/SPHK1/EP300	2.56887507831194
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/563	250/9376	1.59874955595027	ARPC1B/DNM2/VPS37B/WIPF2/IGF2R/ARPC1A/ARFGAP3/HSPA6/SMURF2/VPS26A/WASHC1/WIPF1/CYTH3/IST1/RAB5A/PML/ARF4/CYTH1/CHMP4B/HGS/VPS37D/MDM2/PDCD6IP/ACTR3	2.42522997329531
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/563	35/9376	2.85490992133976	ALDOA/PFKFB4/TIGAR/PFKFB3/HK1/HK3	2.77867728497364
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/563	78/9376	2.13508220613016	ARPC1B/DNM2/ITGA5/CTNNB1/ARPC1A/ITGB1/CRK/WASF1/MAD2L2/ACTR3	2.54423836183337
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/563	138/9376	1.81017839215383	IRS2/KRAS/FLOT1/EIF4E/MAP2K1/PPP1R3B/ELK1/RAPGEF1/BRAF/CRK/PPP1CB/HK1/MKNK2/PHKG1/HK3	2.42331109646335
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/563	203/9376	1.64075282835618	ITGA5/MAP2K1/CTNNB1/BIRC2/ELK1/ACTN1/VASP/CCND3/FLNB/RAPGEF1/ITGB1/BRAF/CRK/VAV3/PPP1CB/PPP1R12C/ITGAV/ITGA7/VEGFA/RAP1A	2.33271028750737
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/563	18/9376	3.70080915729228	ACSL1/ACSL4/ACSL3/CBR4	2.89878883651138
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/563	205/9376	1.6247454836893	IRF7/GTF2H2/IRF9/GTF2B/SP100/KRAS/EIF2AK2/RASA2/YWHAH/ACTN1/JAK3/KAT2B/CCND3/STAT3/HDAC4/UBR4/MDM2/CREB5/RB1/EP300	2.28586016639827
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/563	119/9376	1.81930534203024	MAP3K8/ADAM17/MAP2K1/CEBPB/TAB3/BIRC2/NOD2/MLKL/CX3CL1/CXCL1/CHUK/CREB5/JAG1	2.27332792088701
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/563	250/9376	1.53213499111901	PLEKHM1/SLC11A1/AP1G1/BLOC1S2/IGF2R/BLOC1S6/AP5B1/VPS26A/GGA2/ARL8A/SLC15A4/BLOC1S1/OSTM1/LAMTOR3/IDS/HGSNAT/CTSA/TFE3/NPC1/ARL8B/TLR8/ATP6V1B2/AP3S2	2.15540824619541
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	29/563	333/9376	1.45031710218211	MX1/OASL/MX2/IRF9/KRAS/ITGA5/EIF2AK2/STAT2/MAP2K1/CTNNB1/HES4/TBK1/PPP2R3C/MAML2/PPP2CA/CCND3/ITGB1/UBR4/CHUK/ITGAV/MDM2/CREB5/RB1/WNT11/ITGA7/ATP6V1B2/JAG1/VEGFA/EP300	2.11476562698372
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/563	73/9376	2.05318864205942	PLCG2/KRAS/MAP2K1/JAK3/STAT3/EML4/BRAF/RASSF5/RB1	2.28314785516282
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/563	112/9376	1.78431870083735	HLA-DQA2/IFNGR2/BIRC2/HSPA6/TLR2/PIK3R5/IRAK1/ALOX5/STAT3/IL10/ITGB1/CHUK	2.11047522789241
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/563	42/9376	2.37909160111647	ACSL1/ACSL4/ACSL3/MAP1LC3B/SLC39A8/PRNP	2.26392383091553
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/563	77/9376	1.94652949182256	RUNX1/GAB2/KRAS/MAP2K1/BRAF/CRK/CHUK/MDM2/RB1	2.10784823989589
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/563	193/9376	1.55318933544391	GNG10/PLCG2/KRAS/STAT2/MAP2K1/PRKCD/PIK3R5/JAK3/CXCL8/STAT3/PREX1/BRAF/CRK/VAV3/CX3CL1/CXCL1/CHUK/RAP1A	1.9626285491253
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/563	43/9376	2.3237638894626	ACSL1/CPT1A/ACSL4/ACSL3/ALDH7A1/ACADVL	2.19893339730283
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/563	33/9376	2.5232789708811	STX6/VTI1A/SEC22B/VAMP4/STX5	2.21549713471473
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/563	44/9376	2.27095107379299	MGAT4A/KRTCAP2/ALG13/STT3B/ALG2/MAN2A1	2.13572708882758
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/563	56/9376	2.08170515097691	MGAT4A/DPM1/KRTCAP2/ALG13/STT3B/ALG2/MAN2A1	2.05197897065517
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/563	80/9376	1.87353463587922	PLCG2/NF1/KRAS/EIF4E/MAP2K1/STAT3/IL6R/BRAF/VEGFA	1.98314749673229
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/563	105/9376	1.74466717415208	PLCG2/BCL2A1/TRIM25/TAB3/BIRC2/CXCL8/IRAK1/TICAM2/ERC1/CXCL1/CHUK	1.93941843563292
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/563	105/9376	1.74466717415208	PLCG2/IRF9/KRAS/STAT2/CLEC7A/PRKCD/IL10/CASP1/CHUK/PLK3/MDM2	1.93941843563292
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/563	93/9376	1.79071410836723	SNAI1/CTNNB1/SMURF2/ACTN1/NECTIN2/CTNND1/PDCD10/WASF1/RAP1A/EP300	1.93684442293949
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/563	69/9376	1.93085695163076	PLCG2/GAB2/KRAS/LCP2/MAP2K1/ALOX5/ALOX5AP/VAV3	1.96146510077611
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/563	70/9376	1.90327328089317	ACSL1/CPT1A/IRS2/ADIPOR2/ACSL4/ACSL3/STAT3/CHUK	1.91718759528836
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/563	109/9376	1.68064269069695	HIF1A/HLA-DQA2/IL1RAP/RUNX1/IFNGR2/JAK3/RARA/AHR/STAT3/IL6R/CHUK	1.80651180165655
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/563	110/9376	1.66536412078153	SMAD7/SKI/SKIL/SMURF2/PPP2CA/LEMD3/CUL1/ID2/NRROS/TGIF1/EP300	1.77413851192982
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/563	100/9376	1.66536412078153	TNFRSF10A/TNFRSF10B/CXCL8/TNFRSF10D/ACKR3/IL6R/IL10/CX3CL1/IL24/CXCL1	1.69066265159024
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/563	168/9376	1.48693225069779	IRF9/IFNGR2/TNFRSF10A/EIF2AK2/STAT2/BIRC2/TNFRSF10B/JAK3/STAT3/TICAM2/GLUL/CHMP4B/MLKL/CASP1/AIFM1	1.60960189985949
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	29/563	368/9376	1.31237933431153	PSMA2/PSMA6/NUP98/PSMD9/UQCR11/NDUFA13/NDUFA7/NXT1/NRBF2/ERN1/RANBP2/MAP1LC3B/RAB1A/TBK1/UBQLN1/EIF2AK3/NUP58/NXF1/NDUFC1/RAB5A/NDUFB1/DCTN4/TOMM40L/NEFM/DNAI2/CASP1/NDUFC2/XBP1/ATXN2L	1.54514758067112
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	20/563	238/9376	1.39946564771557	GNG10/PLCG2/GAB2/NF1/KRAS/SHOC2/RASA2/MAP2K1/TBK1/ELK1/RAB5A/RASA3/RALGAPA1/RASSF5/RALGDS/CHUK/BRAP/VEGFA/RAP1A/RASAL3	1.57768497683798
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/563	28/9376	2.37909160111647	B3GNT2/B3GNT5/ST3GAL6/FUT9	1.84710135938246
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/563	212/9376	1.41398840443715	SIPA1L1/KRAS/LCP2/MAP2K1/CTNNB1/ITGAM/SIPA1L2/VASP/RAPGEF1/ITGB1/BRAF/CRK/VAV3/CTNND1/RASSF5/RALGDS/VEGFA/RAP1A	1.54096054011153
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/563	227/9376	1.39391710549996	GNG10/KRAS/MAP2K1/CTNNB1/TBK1/ELK1/TAP1/CXCL8/STAT3/B2M/IL6R/CRK/CX3CL1/CHUK/ITGAV/MDM2/CREB5/RB1/VEGFA	1.51847940303071
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/563	157/9376	1.48503806948671	SMAD7/CTNNB1/YWHAH/BIRC2/FBXW11/PPP2CA/LATS2/CCND3/LIMD1/ID2/PPP1CB/TPTEP2-CSNK1E/WNT11/CSNK1D	1.54903665975146
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	14/563	157/9376	1.48503806948671	IRS2/ADIPOR2/UQCR11/NDUFA13/NDUFA7/ERN1/EIF2AK3/CXCL8/NDUFC1/IL6R/NDUFB1/NDUFC2/XBP1/CEBPA	1.54903665975146
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/563	103/9376	1.6168583696908	ITGAM/TLR2/SERPINB9/ACTN1/GNA15/CXCL8/RAB5A/IL10/CD1D/CXCL1	1.59100628315679
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/563	77/9376	1.73024843717561	KRAS/MAP2K1/STAT3/BRAF/RALGDS/CHUK/RB1/VEGFA	1.62620699754793
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/563	90/9376	1.66536412078153	HIF1A/IFNGR2/KRAS/MAP2K1/TLR2/STAT3/EML4/TICAM2/CHUK	1.60303957384149
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/563	144/9376	1.50345372014999	CPT1A/ADIPOR2/CTNNB1/C3AR1/ALDH7A1/TAB3/TBK1/CXCL8/IRAK1/TRA2A/ACADVL/CXCL1/CHUK	1.53875987496405
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/563	91/9376	1.64706341615755	IFITM1/LILRB1/PLCG2/KRAS/LILRA1/MAP2K1/CD22/VAV3/CHUK	1.56766960827764
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/563	78/9376	1.70806576490413	ITGA5/ITGAM/CXCL8/IRAK1/IL10/TICAM2/ITGB1/CASP1	1.58709921804853
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/563	19/9376	2.62952229597083	HPSE/IDS/HGSNAT	1.79699448140691
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/563	106/9376	1.57109822715238	KRAS/MAP2K1/CTNNB1/NKX3-1/BRAF/CHUK/MDM2/CREB5/RB1/EP300	1.49452033339237
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/563	232/9376	1.36387578857108	ARPC1B/KRAS/ITGA5/MAP2K1/ARPC1A/ITGAM/ACTN1/ITGB1/BRAF/CRK/VAV3/PPP1CB/PPP1R12C/SSH2/WASF1/ITGAV/LIMK1/ITGA7/ACTR3	1.41842701437582
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/563	31/9376	2.14885693004068	SPCS3/SRP19/SEC61G/SEC61B	1.61932899757909
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/563	108/9376	1.54200381553845	AHCTF1/NUP98/NXT1/RANBP2/NUP58/IPO7/NXF1/THOC1/NMD3/KPNA1	1.43185539299913
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/563	20/9376	2.49804618117229	SQLE/CYP51A1/SC5D	1.69501304003202
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/563	122/9376	1.50155781381941	HIF1A/PLCG2/KRAS/ATP2A3/MAP2K1/CTNNB1/KAT2B/ATP2A2/ITGAV/MDM2/EP300	1.40933461554743
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/563	56/9376	1.78431870083735	CUL3/SMURF2/FBXW11/CUL1/TPTEP2-CSNK1E/CSNK1D	1.48784119124915
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/563	44/9376	1.89245922816083	GTF2H2/GTF2B/CCNH/TAF13/TAF11	1.49970316604625
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/563	32/9376	2.08170515097691	GABARAP/PPP2CA/GABARAPL2/ATG3	1.54915696028494
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/563	57/9376	1.75301486398056	ACSL1/CPT1A/ACSL4/ACSL3/CBR4/ACADVL	1.44123324508704
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	29/563	388/9376	1.24473091501712	PSMA2/IRS2/PSMA6/PSMD9/KRAS/FRAT2/EIF2AK2/UQCR11/NDUFA13/ATP2A3/NDUFA7/ADAM17/MAP2K1/CTNNB1/NRBF2/ERN1/EIF2AK3/SNCA/NDUFC1/SLC39A8/NDUFB1/BRAF/TPTEP2-CSNK1E/NDUFC2/ATP2A2/XBP1/NCSTN/CHUK/WNT11	1.24437453608709
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/563	125/9376	1.46552042628774	GAB2/S1PR3/KRAS/MAP2K1/PPP2R3C/PPP2CA/NSMAF/SPTLC1/SGMS1/ORMDL1/SPHK1	1.32427249370551
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/563	45/9376	1.85040457864614	ABCA1/ABCC3/TAP1/DEFB1/ABCA10	1.44525906661202
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	35/563	480/9376	1.21432800473653	PSMA2/PSMA6/PSMD9/KRAS/FRAT2/UQCR11/HTT/NDUFA13/ATP2A3/NDUFA7/MAP2K1/CTNNB1/NRBF2/ERN1/MAP1LC3B/RAB1A/TBK1/EIF2AK3/SNCA/NDUFC1/RAB5A/PRNP/NDUFB1/BRAF/DCTN4/TOMM40L/NEFM/TPTEP2-CSNK1E/DNAI2/NDUFC2/ATP2A2/XBP1/ATXN1/WNT11/ATXN2L	1.21837254252529
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/563	300/9376	1.27677915926584	MAP3K8/IL1RAP/NF1/KRAS/RASA2/MAP2K1/EREG/HSPA6/ELK1/MAP3K2/IRAK1/TAOK3/LAMTOR3/DUSP6/BRAF/CRK/MAP3K21/DUSP8/PPM1A/CHUK/MKNK2/VEGFA/RAP1A	1.23147250583331
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/563	72/9376	1.61910400631537	IRF7/TRIM25/TBK1/CXCL8/IFIH1/AZI2/CHUK	1.33282448460379
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/563	46/9376	1.81017839215383	PSMA2/PSMA6/PSMD9/PSMB10/PSME4	1.39218420025325
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/563	170/9376	1.37147633476126	ARPC1B/RUNX1/RAB8B/ARPC1A/RAP2C/ACTN1/VASP/PPP2CA/WHAMM/ITGB1/CD1D/MPP4/ACTR3/RAP1A	1.23537292192104
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/563	34/9376	1.9592519068018	FBXW11/CUL1/TPTEP2-CSNK1E/CSNK1D	1.41621812666683
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	17/563	214/9376	1.32295280622832	GNG10/PLCG2/KRAS/AP1G1/MAP2K1/TLR2/TBK1/FBXW11/TAP1/IRAK1/B2M/TRIM5/CUL1/ELOC/CRK/CHUK/LIMK1	1.20789381123737
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/563	100/9376	1.49882770870337	HLA-DQA2/FCGR1A/ITGA5/ITGAM/CD44/IL6R/CD22/CD1D/CSF3R	1.26750053142713
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/563	144/9376	1.38780343398461	PSMA2/PSMA6/GTF2B/PSMD9/ATP2A3/NRBF2/ERN1/ATP2A2/XBP1/ATXN1/OPA1/ATXN2L	1.18528543877082
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/563	116/9376	1.43565872481166	PLCG2/CTNNB1/ITGAM/ACTN1/VASP/ITGB1/VAV3/CTNND1/RASSF5/RAP1A	1.19329512882363
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/563	103/9376	1.45517253272172	IFNGR2/TLR2/GNA15/PPP2CA/CXCL8/IRAK1/IL10/TLR6/CHUK	1.17398481574246
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/563	76/9376	1.53388800598299	ACSL1/CPT1A/GK/ACSL4/ACSL3/OLR1/PPARD	1.18111840432101
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/563	104/9376	1.44118048913786	PNPLA6/PGS1/CHKB/SAMD8/GPCPD1/PLPP5/ETNK1/SGMS1/LPCAT2	1.14346850349993
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/563	133/9376	1.37736882169901	PLCG2/IFNGR2/KRAS/TNFRSF10A/LCP2/LAT2/MAP2K1/TNFRSF10B/ULBP2/BRAF/VAV3	1.10780497284829
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/563	37/9376	1.80039364408814	KRAS/MAP2K1/CTNNB1/BRAF	1.23291250116481
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/563	120/9376	1.38780343398461	PLCG2/KRAS/MAP2K1/PRKCD/IRAK1/RAPGEF1/BRAF/IRAK2/CRK/RAP1A	1.08060892719032
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/563	78/9376	1.49455754429111	PATL1/CNOT10/CNOT1/TENT4B/DCP1A/LSM1/TOB1	1.10852964615611
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/563	51/9376	1.63270992233483	PLCG2/PDIA4/SEC61G/SEC61B/ATP6V1B2	1.14509960171488
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/563	38/9376	1.75301486398056	UAP1/RENBP/HK1/HK3	1.17556423030364
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/563	137/9376	1.3371536736202	LMNB1/KRAS/TNFRSF10A/BCL2A1/MAP2K1/ERN1/BIRC2/EIF2AK3/TNFRSF10B/CHUK/AIFM1	1.00473989418509
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/563	94/9376	1.41733116662258	S100A8/CEBPB/TAB3/TBK1/CXCL8/MAPK6/CXCL1/CHUK	1.02778414712452
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/563	66/9376	1.51396738252866	HLA-DQA2/IFNGR2/TLR2/NOD2/STAT3/IL10	1.0590357879654
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/563	227/9376	1.24718898913154	HIF1A/CYP1B1/KRAS/UQCR11/NDUFA13/NDUFA7/MAP2K1/PRKCD/AHR/NDUFC1/NDUFB1/BRAF/ARNT/NDUFC2/CHUK/VEGFA/MGST2	0.952868975252629
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	13/563	168/9376	1.28867461727142	IRF9/IFNGR2/STAT2/JAK3/CCND3/STAT3/IL6R/IL10/PIM1/CSF3R/IL24/SOCS6/EP300	0.954242015671433
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/563	67/9376	1.49137085443122	KRAS/MAP2K1/BRAF/PPP1CB/RAP1A/EP300	1.02017160070433
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/563	83/9376	1.40452395728563	IRF7/TBK1/MEFV/POLR3E/MLKL/CASP1/CHUK	0.935585053914004
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/563	217/9376	1.22791824573753	CYP1B1/KRAS/MAP2K1/BCL6/CCND3/AHR/STAT3/ARNT/VDR/KPNA1/CREB5/RB1/JAG1/VEGFA/PTGES3/MGST2	0.858544640581887
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/563	55/9376	1.51396738252866	ACER3/SAMD8/SPTLC1/SGMS1/SPHK1	0.966192361959128
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/563	99/9376	1.34574878446992	HIF1A/SLC22A4/KRAS/MAP2K1/CHKB/GPCPD1/RALGDS/WASF1	0.874082512492684
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/563	29/9376	1.72279046977399	LATS2/LIMD1/TPTEP2-CSNK1E	0.985265431843195
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/563	71/9376	1.40734996122383	PLCG2/ADAM17/CXCL8/CXCL1/CHUK/ATP6V1B2	0.870796381073104
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/563	115/9376	1.30332844235076	MEF2D/MAP2K1/PDE4D/OXSR1/MEF2A/SGK1/BRAF/VDR/CREB5	0.827201024385316
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/563	86/9376	1.35552893551985	PLCG2/KRAS/MAP2K1/EREG/ELK1/BRAF/CRK	0.837132632714755
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/563	86/9376	1.35552893551985	ITGA5/ATP2A3/CTNNB1/ITGB1/ATP2A2/ITGAV/ITGA7	0.837132632714755
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/563	101/9376	1.31910029368834	PLCG2/KRAS/THBD/PRKCD/CXCL8/STAT3/PIM1/VEGFA	0.81490856459863
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/563	178/9376	1.21627716686291	CACYBP/FRAT2/CTNNB1/FBXW11/CCND3/RYK/CUL1/PPARD/TLE3/TPTEP2-CSNK1E/TLE4/WNT11/EP300	0.73629511812192
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/563	17/9376	1.9592519068018	CSAD/ADO	1.00050752358313
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/563	103/9376	1.29348669575264	NXT1/RNMT/PPP2R3C/PPP2CA/NXF1/PABPN1/PPP1CB/PCF11	0.756963348328128
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/563	59/9376	1.41132552608604	KRAS/MAP2K1/CTNNB1/ELK1/BRAF	0.801035144144391
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/563	149/9376	1.22946344487227	PLCG2/GAB2/DNM2/KRAS/MAP2K1/PIK3R5/CXCL8/CYTH3/CYTH1/RALGDS/SPHK1	0.713599165851037
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/563	60/9376	1.38780343398461	PLCG2/KRAS/MAP2K1/SPHK1/VEGFA	0.761641301073757
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/563	76/9376	1.31476114798542	PLCG2/KRAS/MAP2K1/BRAF/MDM2/RB1	0.696344890097851
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/563	122/9376	1.22854730221588	MAP3K8/KRAS/LCP2/MAP2K1/PPP2R3C/PPP2CA/IL10/VAV3/CHUK	0.642198397528695
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/563	47/9376	1.41733116662258	IRS2/PRKCD/HK1/HK3	0.72492011783919
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/563	138/9376	1.20678559476922	REC8/MAP2K1/YWHAH/CPEB4/FBXW11/PPP2CA/CPEB2/CUL1/PPP1CB/MAD2L2	0.618512948809776
NA	NA	hsa04518	Integrin signaling	11/563	154/9376	1.18954580055823	ITGA5/LIMS1/CTNNB1/ITGAM/ACTN1/CCND3/FLNB/ITGB1/ITGAV/ITGA7/VEGFA	0.59943199370906
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/563	63/9376	1.32171755617582	POLR2J3/GTF2H2/POLD4/CCNH/POLR2B	0.647557272085778
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/563	140/9376	1.18954580055823	MEF2D/GNG10/KRAS/MAP2K1/MAP1LC3B/PIK3R5/MEF2A/HDAC4/SPHK1/JAG1	0.571102647200787
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/563	34/9376	1.46943893010135	POLR2J3/POLR3E/POLR2B	0.693069169275034
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/563	362/9376	1.10410880935792	GNG10/KRAS/EIF4E/ITGA5/MAP2K1/YWHAH/EREG/TLR2/PIK3R5/JAK3/PPP2R3C/PPP2CA/CCND3/IL6R/ITGB1/SGK1/CSF3R/CHUK/ITGAV/MDM2/CREB5/PHLPP1/ITGA7/VEGFA	0.51057663724284
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/563	20/9376	1.66536412078153	UAP1/CYB5R4	0.752847859611091
NA	NA	hsa04517	IgSF CAM signaling	20/563	299/9376	1.11395593363313	IL1RAP/ARPC1B/PLCG2/ITGA5/LCP2/MAP2K1/CTNNB1/ARPC1A/ITGAM/EPB41L3/MBP/ACTN1/NECTIN2/ITGB1/SRGAP1/VAV3/ERC1/GRIP2/ACTR3/RAP1A	0.506150092582278
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/563	95/9376	1.22711040478639	HLA-DQA2/TNFSF13/TLR2/CXCL8/CXCL1/ATP6V1B2/VEGFA	0.562314649841046
Organismal Systems	Immune system	hsa04611	Platelet activation	9/563	126/9376	1.18954580055823	PLCG2/P2RX1/LCP2/FCGR2A/PIK3R5/VASP/ITGB1/PPP1CB/RAP1A	0.541385380178511
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/563	158/9376	1.1594307169998	KRAS/SLC7A5/EIF4E/MAP2K1/CASTOR1/LAMTOR3/SGK1/BRAF/CHUK/WNT11/ATP6V1B2	0.510810882880342
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/563	50/9376	1.33229129662522	LAP3/ALDH7A1/OAT/P4HA1	0.595434800413008
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/563	21/9376	1.58606106741098	DSE/CSGALNACT2	0.67952990450318
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/563	36/9376	1.38780343398461	HK1/GBE1/HK3	0.589206342640774
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/563	83/9376	1.20387767767339	PHC2/EZH2/FOXK2/UBE2D1/AEBP2/EP300	0.471529323844824
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/563	83/9376	1.20387767767339	ACSL1/ACSL4/ACSL3/FAR1/PEX11G/PEX13	0.471529323844824
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/563	99/9376	1.17753018641118	HLA-DQA2/FCGR1A/FCGR2A/C3AR1/ITGAM/DEFB1/IL10	0.448811502315142
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/563	37/9376	1.3502952330661	UAP1/HK1/HK3	0.539588707551108
NA	NA	hsa04519	Cadherin signaling	26/563	404/9376	1.07176898862178	ARPC1B/KRAS/SHOC2/LHFPL4/MAP2K1/CTNNB1/YWHAH/ARPC1A/FMN1/ACTN1/VASP/LATS2/RYK/TAOK3/LIMD1/VAV3/CTNND1/PPP1CB/LHFPL2/PCDHB9/WASF1/NCSTN/CHUK/WNT11/ACTR3/EP300	0.372701230665492
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/563	38/9376	1.31476114798542	NT5C2/PNP/SIRT6	0.491387307688685
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/563	23/9376	1.44814271372307	GLS/GLUL	0.543854518460895
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/563	23/9376	1.44814271372307	NUS1/IDI1	0.543854518460895
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/563	23/9376	1.44814271372307	MAS1/CTSA	0.543854518460895
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/563	39/9376	1.2810493236781	MTHFS/ALDH7A1/MAT2A	0.444517762060182
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/563	87/9376	1.14852697984933	KRAS/MAP2K1/CTNNB1/EREG/BRAF/RALGDS	0.351769713961146
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/563	235/9376	1.06299837496693	ACSL1/CPT1A/COX16/KRAS/ACSL4/UQCR11/NDUFA13/NDUFA7/ACSL3/NDUFC1/NDUFB1/COX17/NDUFC2/SIRT6/CREB5	0.247197670765052
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/563	170/9376	1.07758854874099	PLCG2/KRAS/FRAT2/MAP2K1/CTNNB1/ELK1/ARID2/BRAF/RB1/WNT11/MGST2	0.258026644489667
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/563	89/9376	1.12271738479654	GABARAP/GNG10/SLC38A2/GLS/GABARAPL2/GLUL	0.29399593302102
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/563	73/9376	1.14066035669968	KRAS/MAP2K1/BRAF/MDM2/RB1	0.304929600339523
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/563	122/9376	1.09204204641412	CPT1A/IRS2/ADIPOR2/PFKFB4/PPP2R3C/PPP2CA/PFKFB3/CREB5	0.258630288519328
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/563	122/9376	1.09204204641412	PLCG2/IRS2/KRAS/MAP2K1/STAT3/CRK/CREB5/EP300	0.258630288519328
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/563	155/9376	1.07442846502034	MAP2K1/CTNNB1/KMT2D/AHR/BRAF/ARNT/CREB5/RB1/WNT11/RAP1A	0.236153208784347
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/563	42/9376	1.18954580055823	CYP1B1/ALDH7A1/KYNU	0.311159356337424
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/563	157/9376	1.06074147820479	KRAS/MAP2K1/FBXW11/CXCL8/CCND3/HIPK2/PPP1CB/RASSF5/MDM2/RB1	0.193986374319631
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/563	75/9376	1.11024274718769	TNFRSF10A/CD82/TNFRSF10B/CCND3/MDM2	0.242266735409756
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/563	109/9376	1.06949989407988	CPT1A/IRS2/PRKCD/PPP1R3B/STAT3/PPP1CB/CREB5	0.18446151054766
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/563	93/9376	1.07442846502034	HLA-DQA2/IFNGR2/JAK3/MAML2/CHUK/JAG1	0.182311603975634
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/563	60/9376	1.11024274718769	KRAS/MAP2K1/PPP2CA/BRAF	0.216515435511349
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/563	44/9376	1.1354755368965	RAB5A/DCTN4/CREB5	0.22765532048359
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/563	144/9376	1.04085257548845	SKIL/KRAS/MAP2K1/CTNNB1/JAK3/HESX1/STAT3/ID2/WNT11	0.124862130191125
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/563	195/9376	1.02483945894248	PLCG2/FCGR1A/SIGLEC9/FCGR2A/CLEC7A/MAP2K1/ITGAM/TLR2/AQP9/HDAC4/CASP1/TLR8	0.0885915691952517
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/563	12/9376	1.38780343398461	NPC1	0.339742220937358
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/563	63/9376	1.05737404494065	EZH2/ALDH7A1/KMT2D/COLGALT1	0.115483222214929
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/563	47/9376	1.06299837496693	ALDH7A1/ACYP2/ME2	0.109430574702339
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/563	166/9376	1.00323139806116	MEF2D/IRS2/ATP2A3/MAP2K1/PIK3R5/MEF2A/VASP/PPP1CB/ATP2A2/CREB5	0.0106167756367308
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/563	30/9376	1.11024274718769	ABCC3/CHUK	0.152853615834957
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/563	99/9376	1.00931158835244	KRAS/MAP2K1/BRAF/MDM2/RB1/JAG1	0.0235404921376007
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/563	99/9376	1.00931158835244	ITGA5/ATP2A3/ITGB1/ATP2A2/ITGAV/ITGA7	0.0235404921376007
NA	NA	hsa03272	Virion - Hepatitis viruses	3/563	48/9376	1.04085257548845	IST1/CHMP4B/PDCD6IP	0.0717172687487713
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/563	31/9376	1.07442846502034	ALDH7A1/CSAD	0.104907903239501
NA	NA	hsa04981	Folate transport and metabolism	2/563	31/9376	1.07442846502034	MTHFS/ABCC3	0.104907903239501
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/563	67/9376	0.994247236287479	ALDOA/ALDH7A1/HK1/HK3	-0.0119437408876634
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/563	14/9376	1.18954580055823	B3GNT2	0.179379090195384
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/563	32/9376	1.04085257548845	HK1/HK3	0.058506748910597
Human Diseases	Immune disease	hsa05310	Asthma	2/563	32/9376	1.04085257548845	HLA-DQA2/IL10	0.058506748910597
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	18/563	308/9376	0.973264745911282	POLR2J3/PSMA2/PSMA6/PSMD9/UQCR11/HTT/NDUFA13/NDUFA7/NRBF2/ERN1/NDUFC1/NDUFB1/DCTN4/DNAI2/NDUFC2/POLR2B/CREB5/EP300	-0.120581829559709
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/563	85/9376	0.979625953400899	CMPK2/ADK/NT5C2/UPP1/PNP	-0.047690676005947
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/563	50/9376	0.999218472468916	HLA-DQA2/TNFSF13/IL10	-0.00140042394794584
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/563	50/9376	0.999218472468916	TLR2/CXCL8/IL10	-0.00140042394794584
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/563	224/9376	0.966505962953565	HLA-DQA2/KRAS/MAP2K1/ELK1/CRTC3/JAK3/KAT2B/CCND3/B2M/CHUK/CREB5/RB1/EP300	-0.128236439225932
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/563	138/9376	0.965428475815378	UQCR11/NDUFA13/NDUFA7/NDUFC1/NDUFB1/COX17/NDUFC2/ATP6V1B2	-0.103406310251653
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/563	139/9376	0.95848294721239	FKBP5/KRAS/MAP2K1/PRKCD/HSPA6/RARA/CREB5/FKBP4	-0.124636830129368
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/563	105/9376	0.951636640446587	ITGA5/ATP2A3/ITGB1/ATP2A2/ITGAV/ITGA7	-0.125958004304185
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/563	158/9376	0.948625132090744	CCNH/YWHAH/PPP2CA/CCND3/CUL1/MDM2/RB1/MAD2L2/EP300	-0.164603422279168
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/563	71/9376	0.938233307482551	KRAS/MAP2K1/STAT3/SOCS6	-0.132039321063041
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/563	89/9376	0.935597820663779	ITGA5/CD44/ITGB1/ITGAV/ITGA7	-0.154289295146988
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/563	107/9376	0.933849039690576	CPT1A/SIK2/SIK1/CREB5/PHKG1/EP300	-0.173936029286575
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/563	16/9376	1.04085257548845	MIF	0.0413351443582072
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/563	16/9376	1.04085257548845	FUT9	0.0413351443582072
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/563	90/9376	0.925202289323071	IRS2/ADIPOR2/KRAS/EIF4E/CREB5	-0.180207628429117
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/563	17/9376	0.979625953400899	GLUL	-0.0212502959480132
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/563	110/9376	0.908380429517197	KRAS/MAP2K1/CPEB4/CPEB2/BRAF/MAD2L2	-0.244296022828952
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/563	37/9376	0.900196822044069	GLS/GLUL	-0.153735086062595
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/563	93/9376	0.895357054183617	KRAS/MAP2K1/PRKCD/ELK1/MAP3K2	-0.256321600765331
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/563	93/9376	0.895357054183617	BIRC2/ITGB1/CHUK/ITGAV/RB1	-0.256321600765331
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/563	323/9376	0.928066692695588	PLCG2/ST14/IRS2/CYP1B1/KRAS/ITGA5/MAP2K1/EZH2/CD44/STAT3/GLS/HDAC4/CRK/PIM1/HOXD10/MDM2/VEGFA/EP300	-0.332516331146874
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/563	148/9376	0.900196822044069	KRAS/FRAT2/MAP2K1/CTNNB1/BRAF/RB1/WNT11/JAG1	-0.309313863612942
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/563	18/9376	0.925202289323071	LMBRD1	-0.0802806700064166
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/563	38/9376	0.876507431990278	KRAS/SGK1	-0.192789614926271
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/563	38/9376	0.876507431990278	JAK3/TAP1	-0.192789614926271
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/563	275/9376	0.908380429517197	PSMA2/PSMA6/PSMD9/UQCR11/NDUFA13/NDUFA7/PRKCD/HSPA6/STIP1/EIF2AK3/NDUFC1/PRNP/NDUFB1/NDUFC2/CREB5	-0.389751676304663
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/563	39/9376	0.854032882452065	HLA-DQA2/IL10	-0.230866865565205
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/563	59/9376	0.846795315651624	CMPK2/NT5C2/UPP1	-0.298358182577092
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/563	78/9376	0.854032882452065	PLCG2/PIK3C2A/INPP4A/MTMR3	-0.327179069521164
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/563	41/9376	0.812372741844648	ALDH7A1/ALAS1	-0.304304692875747
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/563	41/9376	0.812372741844648	POLD4/EME1	-0.304304692875747
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/563	21/9376	0.793030533705489	CSAD	-0.239978305140609
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/563	62/9376	0.805821348765255	IRS2/KRAS/HSPA6	-0.387710139254518
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/563	101/9376	0.824437683555212	KRAS/MAP2K1/CTNNB1/WNT11/EP300	-0.448345671005132
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/563	82/9376	0.812372741844648	HLA-DQA2/HSPA6/TAP1/B2M	-0.431300016582603
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/563	63/9376	0.793030533705489	ALOX5/LTA4H/PTGES3	-0.416590827655919
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/563	268/9376	0.869966331751544	PSMA2/PSMA6/PSMD9/UQCR11/NDUFA13/NDUFA7/ERN1/EIF2AK3/SNCA/NDUFC1/SLC39A8/NDUFB1/NDUFC2/XBP1	-0.54587053271274
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/563	22/9376	0.756983691264331	ALDH7A1	-0.28842043539013
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/563	44/9376	0.756983691264331	POLD4/NEIL3	-0.40836860229774
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/563	160/9376	0.832682060390764	HLA-DQA2/CD58/SELL/ITGAM/NECTIN2/ITGB1/CD22/ITGAV	-0.539522072375685
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/563	142/9376	0.820954144047232	THBD/CTNNB1/MEF2A/CHUK/ITGAV/VEGFA/MGST2	-0.543364750651634
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/563	65/9376	0.768629594206859	GK/ALDH7A1/PLPP5	-0.473090550818323
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/563	23/9376	0.724071356861534	FUT9	-0.334859933562085
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/563	23/9376	0.724071356861534	POLD4	-0.334859933562085
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/563	23/9376	0.724071356861534	GLS	-0.334859933562085
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/563	24/9376	0.693901716992303	HS3ST3B1	-0.379482904435457
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/563	87/9376	0.765684653232886	UQCR11/ATP2A3/ASPH/ATP2A2	-0.554949966616093
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/563	184/9376	0.814580276469225	PLCG2/KRAS/SEMA6B/RYK/ITGB1/SRGAP1/SSH2/PLXNC1/LIMK1	-0.642004073133197
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/563	128/9376	0.780639431616341	ADK/NT5C2/PDE4D/PDE6D/PNP/NUDT9	-0.631564321274515
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/563	89/9376	0.748478256531024	KRAS/MAP2K1/MAP3K2/CSNK1D	-0.602574523314996
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/563	48/9376	0.693901716992303	HK1/HK3	-0.537359825262532
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/563	205/9376	0.812372741844648	UQCR11/NDUFA13/ATP2A3/NDUFA7/PRKCD/NDUFC1/NDUFB1/PPP1CB/NDUFC2/ATP2A2	-0.686503042831352
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/563	298/9376	0.838270530594729	IL1RAP/IFNGR2/TNFRSF10A/TNFSF13/TNFRSF10B/CXCL8/TNFRSF10D/ACKR3/IL6R/IL10/CSF3R/RELT/CX3CL1/IL24/CXCL1	-0.717100714359302
Genetic Information Processing	Transcription	hsa03040	Spliceosome	12/563	243/9376	0.822402034953841	HSPA6/CTNNBL1/SNIP1/SNRNP27/BCAS2/DHX15/CDC40/TRA2A/PHF5A/BUD31/THOC1/SRSF4	-0.708944673323609
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/563	149/9376	0.78238582855508	GNG10/NDUFA13/NDUFA7/NDUFC1/NDUFB1/NDUFC2/DAGLB	-0.676749585568637
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/563	26/9376	0.640524661839049	LMBRD1	-0.46390378936973
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/563	130/9376	0.768629594206859	GNG10/KRAS/MAP2K1/GNA15/CREB5/VEGFA	-0.671398691399826
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/563	49/9376	0.679740457461848	COLGALT1/GALNT3	-0.568076836509321
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/563	150/9376	0.77716992303138	KRAS/FRAT2/MAP2K1/CTNNB1/BRAF/RB1/WNT11	-0.695329516206384
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/563	226/9376	0.810575457017558	ATP2A3/MAP2K1/PDE4D/BRAF/VAV3/PPP1CB/GIPR/ATP2A2/CREB5/RAP1A/EP300	-0.728547498264364
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/563	28/9376	0.594772900279117	ATP6V1B2	-0.542745330438599
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/563	154/9376	0.756983691264331	ATP2A3/PIK3R5/PPP2R3C/PPP2CA/PPP1CB/ATP2A2/CREB5	-0.768530613815863
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/563	52/9376	0.640524661839049	CYP1B1/ALOX5	-0.656973104999846
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/563	52/9376	0.640524661839049	ABCA1/NPC1	-0.656973104999846
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/563	115/9376	0.724071356861534	GNG10/KRAS/MAP2K1/PIK3R5/CREB5	-0.752479571294041
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/563	115/9376	0.724071356861534	GNG10/KRAS/MAP2K1/ALOX5/BRAF	-0.752479571294041
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/563	116/9376	0.717829362405831	GNG10/SLC38A2/GLS/GLUL/HOMER3	-0.772882139531906
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/563	53/9376	0.628439290860954	DNM2/VDR	-0.685595291552682
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/563	75/9376	0.666145648312611	ALDOA/MAT2A/GLUL	-0.733670068543787
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/563	75/9376	0.666145648312611	BIRC2/MDM2/MGST2	-0.733670068543787
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/563	75/9376	0.666145648312611	PDIA4/ASGR2/CREB5	-0.733670068543787
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/563	117/9376	0.711694068710054	GATAD2A/GATAD2B/SS18L1/ARID2/PHF6	-0.793126419222681
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/563	54/9376	0.616801526215381	HLA-DQA2/IL10	-0.713746599029975
NA	NA	hsa04382	Cornified envelope formation	10/563	217/9376	0.767448903585957	ST14/S100A8/S100A12/ABHD5/S100A2/PPP2R3C/PPP2CA/PLEC/SPTLC1/S100A6	-0.875996113613646
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/563	98/9376	0.679740457461848	PLCG2/PIK3C2A/INPP4A/MTMR3	-0.805500627877305
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/563	99/9376	0.672874392234961	IL1RAP/PLCG2/PRKCD/PPP1CB	-0.827001528217482
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/563	31/9376	0.53721423251017	ALDOA	-0.652302643930293
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/563	31/9376	0.53721423251017	ALDH7A1	-0.652302643930293
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/563	31/9376	0.53721423251017	GLUL	-0.652302643930293
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/563	32/9376	0.520426287744227	BIRC2	-0.686818356776573
Genetic Information Processing	Translation	hsa03010	Ribosome	10/563	222/9376	0.750164018370057	RPL36A/RPS10/RPL17/RPS21/MRPL33/MRPL53/RPS17/MRPL23/RPL39/MRPL52	-0.952146926403322
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/563	59/9376	0.564530210434416	LAP3/MGST2	-0.848054845937833
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/563	59/9376	0.564530210434416	IRS2/ABHD5	-0.848054845937833
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/563	82/9376	0.609279556383486	CES1/UPP1/MGST2	-0.898151662331677
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/563	36/9376	0.462601144661535	GALNT3	-0.816493064127647
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/563	36/9376	0.462601144661535	POLD4	-0.816493064127647
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/563	63/9376	0.528687022470326	CTNNB1/WNT11	-0.948664877526768
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/563	37/9376	0.450098411022035	MIF	-0.847058879676298
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/563	37/9376	0.450098411022035	IL10	-0.847058879676298
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/563	88/9376	0.567737768448248	THBD/C3AR1/ITGAM	-1.02968758023641
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/563	154/9376	0.648843163940855	KRAS/MAP2K1/ELK1/PIK3R5/PPP1CB/PPP1R12C	-1.11052126569709
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/563	133/9376	0.626076737135913	GNG10/PPP2R3C/PPP2CA/PPP1CB/CREB5	-1.09769018065538
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/563	65/9376	0.512419729471239	KRAS/MAP2K1	-0.996971146598717
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/563	134/9376	0.621404522679674	MAP2K1/PRKCD/BRAF/PPP1CB/PPP1R12C	-1.11563669196308
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/563	116/9376	0.574263489924665	ALDOA/HK1/ME2/HK3	-1.16611759320301
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/563	69/9376	0.482714237907689	PPP1CB/CREB5	-1.09000418130295
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/563	70/9376	0.475818320223294	CYP1B1/MGST2	-1.1125698450325
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/563	43/9376	0.387293981577099	ABCA1	-1.01777948270331
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/563	44/9376	0.378491845632165	HLA-DQA2	-1.04439252507907
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/563	143/9376	0.582295147126408	HLA-DQA2/FCGR1A/FCGR2A/ACTN1/IL10	-1.27216684366572
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/563	45/9376	0.370080915729228	HLA-DQA2	-1.07054488020707
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/563	46/9376	0.362035678430767	ALAS1	-1.09625714214966
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/563	233/9376	0.643273694722479	LMNB1/ITGA5/FMNL3/PLEC/PDLIM7/ITGB1/ITGAV/TMOD3/ITGA7	-1.39362743385715
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/563	191/9376	0.610342871490612	GNG10/KRAS/MAP2K1/HDAC4/BRAF/PPP1CB/CREB5	-1.37511075769528
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/563	48/9376	0.346950858496152	ALDH7A1	-1.14643691927384
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/563	102/9376	0.489812976700449	ATP2A3/ATP2A2/RAP1A	-1.30940470985042
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/563	49/9376	0.339870228730924	CREB5	-1.17093913635215
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/563	79/9376	0.421611169818108	CYP1B1/MGST2	-1.30478807250686
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/563	79/9376	0.421611169818108	DNM2/ATP6V1B2	-1.30478807250686
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/563	51/9376	0.326541984466966	LPCAT2	-1.21884686510489
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/563	154/9376	0.540702636617379	CMPK2/MAT2A/PDXK/KYNU/ALAS1	-1.45251191757832
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/563	54/9376	0.30840076310769	MAT2A	-1.2881747631935
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/563	54/9376	0.30840076310769	EME1	-1.2881747631935
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/563	183/9376	0.546021023207058	NXT1/NXF1/GNL3L/RMRP/NMD3/FCF1	-1.567511035657
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/563	86/9376	0.387293981577099	FFAR1/CREB5	-1.44268483107447
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/563	254/9376	0.590089649095817	PLCG2/P2RX1/ATP2A3/GNA15/ASPH/ATP2A2/SPHK1/VEGFA/PHKG1	-1.67393526971658
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/563	90/9376	0.370080915729228	ABCC3/AQP9	-1.51764303013208
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/563	91/9376	0.366014092479457	GNG10/PDE4D	-1.53598614058297
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/563	61/9376	0.273010511603529	VDR	-1.43972507911272
Cellular Processes	Cell motility	hsa04814	Motor proteins	6/563	194/9376	0.515061068282947	KIF1B/KIFC3/KIF13B/DYNLT1/DCTN4/DNAI2	-1.72503226578012
NA	NA	hsa04081	Hormone signaling	7/563	219/9376	0.532308166459849	GNG10/IRS2/ADIPOR2/GNA15/STAT3/GIPR/ITGAV	-1.77004043507077
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/563	65/9376	0.25620986473562	CREB5	-1.52085174237911
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/563	66/9376	0.25232789708811	CYP1B1	-1.54058709086055
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/563	98/9376	0.339870228730924	DAGLB/CREB5	-1.66032506330205
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/563	70/9376	0.237909160111647	HLA-DQA2	-1.61752941841931
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/563	73/9376	0.228132071339935	MGST2	-1.67328865448378
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/563	86/9376	0.19364699078855	TAS2R19	-1.89864832383231
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/563	97/9376	0.171687022760982	GNG10	-2.07256278589581
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/563	103/9376	0.16168583696908	SLC38A2	-2.1621869235722
NA	NA	hsa04082	Neuroactive ligand signaling	2/563	199/9376	0.167373278470505	GNG10/P2RX1	-3.00057486876958
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/563	370/9376	0.225049205511017	S1PR3/P2RX1/C3AR1/MAS1/GIPR	-3.84403177691586
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/563	449/9376	0.111271544818365	OR11G2/OR3A3/SLC24A4	-4.87772643265149