category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	65/987	238/9376	2.59439946191242	RPS10/RPL36A/RPL17/RPS21/RPS27/RPL41/RPL26/RPS29/RPL39/RPS17/RPL37/RPL34/PLCG2/RPS15A/MX1/RPL38/MX2/RPL14/NFKB1/ADAM17/RPS25/RPL30/RSL24D1/RPS6/EIF2AK2/RPL27/RPL23A/RPL32/IFIH1/RPS28/RPS23/RPL12/FAU/RPL22L1/RPL9/IRF9/RPL35A/RPL36/RPL37A/RPL22/RPL6/RPS4X/RPS3A/RPS18/RPS7/PIK3CA/RPL36AL/MAS1/TBK1/RPL7A/RPL3/OAS2/ISG15/MAPK8/RPL5/RPS27A/CASP1/TRAF3/RPL24/IKBKB/RPL17-C18orf32/RPS13/RPL21/CHUK/RPS19	8.54572981987997
Genetic Information Processing	Translation	hsa03010	Ribosome	59/987	222/9376	2.52464014166142	RPS10/RPL36A/RPL17/RPS21/RPS27/RPL41/RPL26/RPS29/RPL39/RPS17/RPL37/RPL34/RPS15A/RPL38/RPL14/RPS25/RPL30/RSL24D1/RPS6/RPL27/RPL23A/RPL32/MRPL10/RPS28/RPS23/RPL12/FAU/RPL22L1/RPL9/RPL35A/RPL36/MRPL33/RPL37A/RPL22/RPL6/RPS4X/RPS3A/RPS18/RPS7/RPL36AL/MRPS25/RPL7A/RPL3/MRPL23/MRPL1/MRPL47/RPL5/RPS27A/RPL24/MRPL30/RPL17-C18orf32/MRPS6/MRPS17/MRPL50/RPS13/RPL21/MRPL22/MRPL49/RPS19	7.88546848668082
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	39/987	122/9376	3.03672330459913	NFATC1/PPP2R5C/NFKB1/NFKBIE/CD3E/AKT3/PPP2R5A/SOS2/CBLB/MAP3K8/CD8A/PPP3R1/NCK2/MALT1/RASGRP1/PPP2R3C/PPP2R2D/MAP3K14/SOS1/FYN/PPP2CA/PIK3CA/MAP2K1/CD3D/ICOS/PPP3CA/PPP3CC/MAP2K7/MAPK8/PRKCQ/CD28/IKBKB/BCL10/PDPK1/PPP2R2B/CHUK/ITK/NCK1/PPP2R3A	7.76669620105242
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	46/987	174/9376	2.5113603279414	ERO1B/KRTCAP2/NFE2L2/EDEM1/SVIP/HERPUD1/SSR3/DNAJA1/DERL1/UBE2J1/SAR1A/SEC24A/SEC61G/ERP29/SELENOS/UBXN2A/HSPA8/DNAJB2/BAG1/SEC23A/STT3B/DNAJC3/ERN1/MAP2K7/SKP1/DERL2/MAPK8/UBQLN2/PDIA6/SEC63/RPN2/TRAM1/HYOU1/RAD23B/NGLY1/TMEM258/CAPN2/DNAJB11/RPN1/DNAJA2/SEC61B/UBXN1/LMAN1/SAR1B/UBQLN1/MAP3K5	6.90224935993654
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	49/987	205/9376	2.27061062099983	HLA-C/B2M/TNFAIP3/CD44/PLCG2/NFKB2/TAP1/IRF7/NFKB1/RELB/HLA-B/HLA-DQA2/NFKBIE/BCL2L11/CD3E/AKT3/EIF2AK2/VIM/IRF9/PSMD12/MAP2K3/CYCS/TAP2/MAP3K14/CD58/CASP3/CCND2/HLA-A/PIK3CA/MAP2K4/CD3D/TBK1/PSMC4/CASP8/TAPBP/OAS2/MAP2K7/ISG15/RUNX3/MAPK8/HLA-DPB1/PSMC6/TRAF3/IKBKB/ICAM1/CCNE2/GADD45A/HLA-DQB1/CHUK	6.30914025991691
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	44/987	180/9376	2.3220983901835	HLA-C/PPP1CB/IFNGR1/B2M/SRSF6/SOCS3/BIRC2/ZC3HAV1/TAP1/IRF7/NFKB1/SRSF5/HLA-B/HLA-DQA2/AKT3/EIF2AK2/IFIH1/ITGA5/IRF9/SRSF3/CYCS/TAP2/EIF2B4/SRSF2/RHEB/PPP1CC/CASP3/BIRC3/SRSF1/HLA-A/PIK3CA/TBK1/CASP8/TAPBP/OAS2/HLA-DPB1/TRAF3/IKBKB/SRSF7/HLA-DQB1/CHUK/JAK2/BST2/ALYREF	6.14312942176185
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	72/987	368/9376	1.85859653759746	NDUFA13/PSMA2/TUBA4A/TUBB2A/HNRNPA1/TUBB4B/MAP1LC3B/PSMD9/MT-ATP8/NUP98/PSMA6/NUP54/NDUFB1/NDUFA7/NUP153/TUBA1A/NXT1/SQSTM1/NUP58/ULK1/PPP3R1/ATXN2L/UQCRFS1/PSMD12/DERL1/NDUFV2/RAB1A/SRSF3/SDHA/MAP2K3/CYCS/NDUFB8/UQCRB/MT-ND4L/NDUFA1/DCTN6/RANBP2/NDUFC1/VAPB/NDUFA6/PSMA1/RAB5A/CASP3/UQCRC2/NDUFS5/TARDBP/TBK1/ERN1/PSMC4/PPP3CA/PPP3CC/UQCR11/COX7C/TUBA8/UBQLN2/SOD1/COX7B/CASP1/PSMC6/NDUFC2/NUP88/SLC1A2/OPTN/TANK/SRSF7/POM121/UBQLN1/VDAC1/MAP3K5/PSMB2/WIPI2/ALYREF	5.76352220527926
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	45/987	196/9376	2.18100614105825	HLA-C/IFNGR1/CTNNB1/PLCG2/NFATC1/IRF7/NFKB1/MAP1LC3B/HLA-B/AKT3/ZFP36/EIF2AK2/PPP3R1/GNG2/IRF9/CYCS/CALM2/TCF7/HIF1A/CASP3/HLA-A/PIK3CA/MAP2K4/MAP2K1/TBK1/CASP8/PPP3CA/PIK3R5/PPP3CC/MAPKAPK2/MAP2K7/ATG3/MAPK8/RPS27A/LEF1/TRAF3/UBC/MICA/CLEC2B/IKBKB/MICB/ICAM1/CHUK/JAK2/CALM3	5.73123172639661
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	29/987	103/9376	2.67461465065266	PPP1CB/PPP2R5C/DAZAP1/PPP2R5A/EIF4A3/PABPC1/NXT1/SMG1/RNMT/PPP2R3C/PCF11/GSPT1/PPP2R2D/ETF1/RBM8A/PPP1CC/PABPC4/DDX39B/PPP2CA/TARDBP/SSU72/DDX19B/MAGOH/NCBP2/CLP1/PPP2R2B/RNPS1/ALYREF/PPP2R3A	5.86155016524895
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	25/987	83/9376	2.86129319710453	EZH2/AUTS2/RYBP/PHF1/KDM2B/TFDP1/FOXK1/ASXL1/OGT/AEBP2/KDM2A/FOXK2/FBRS/PHC3/PCGF5/CBX6/YAF2/BCOR/SKP1/FBRSL1/EZH1/CBX4/RNF2/USP16/MAX	5.84204617106405
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	29/987	109/9376	2.52738815612132	IFNGR1/RARA/NFATC1/TGFB1/NFKB1/SMAD3/HLA-DQA2/NFKBIE/CD3E/IL4R/PPP3R1/IL23A/IRF4/GATA3/IL27RA/HIF1A/CD3D/PPP3CA/PPP3CC/MAPK8/PRKCQ/HLA-DPB1/IL21R/STAT5B/IKBKB/HLA-DQB1/CHUK/JAK2/STAT5A	5.50151375857553
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	26/987	93/9376	2.65577235240928	IFNGR1/NFATC1/NFKB1/STAT4/HLA-DQA2/NFKBIE/CD3E/IL4R/PPP3R1/GATA3/IL12RB2/CD3D/PPP3CA/PPP3CC/MAML1/MAF/RUNX3/MAPK8/PRKCQ/HLA-DPB1/STAT5B/IKBKB/HLA-DQB1/CHUK/JAK2/STAT5A	5.50410921761642
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/987	248/9376	1.915220446449	TUBA4A/TUBB2A/CTNNB1/BIRC2/RHOH/NFKB1/TUBB4B/PLEKHM1/ARPC1B/ARF6/AKT3/CYTH2/TUBA1A/CYTH1/KPNA4/RAB9A/MAP2K3/CYCS/PIK3C2A/DYNLT3/S100A10/DCTN6/TCF7/SNX9/RAB5A/DYNLL2/DYNC1H1/CASP3/BIRC3/PIK3CA/MAP2K4/MAP2K1/CASP8/ELMO1/TUBA8/MAP2K7/RIPK2/SKP1/MAPK8/PIK3C2B/LEF1/CASP1/PKN1/TNFRSF10B/KPNA3/IKBKB/CHUK/M6PR/ARL8B/DNM2	5.01017454284387
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	36/987	157/9376	2.1782277892862	NDUFA13/IRS2/SOCS3/TGFB1/NFKB1/BCL2L11/ADIPOR2/AKT3/NDUFB1/NDUFA7/ITCH/UQCRFS1/NDUFV2/SDHA/CYCS/NDUFB8/UQCRB/NDUFA1/NDUFC1/NDUFA6/CASP3/UQCRC2/NDUFS5/PIK3CA/ERN1/CASP8/UQCR11/COX7C/MAPK8/MLXIP/COX7B/NDUFC2/IKBKB/PRKAA1/MAP3K5/SREBF1	5.10653482134509
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/987	105/9376	2.44272687798524	PLCG2/NFATC1/NFKB2/NFKB1/RELB/PLK3/AKT3/CBLB/BCL3/CYLD/PPP3R1/IRF9/IL23A/MALT1/CALM2/MAP3K14/PIK3CA/CASP8/PPP3CA/PPP3CC/MAPKAPK2/MAPK8/CASP1/IKBKB/BCL10/CHUK/CALM3	5.09922997542389
Human Diseases	Infectious disease: viral	hsa05162	Measles	32/987	136/9376	2.23517492103224	TNFAIP3/MX1/MX2/IRF7/NFKB1/BBC3/CD3E/AKT3/EIF2AK2/CBLB/IFIH1/IRF9/RAB9A/CYCS/CASP3/HSPA8/CCND2/PIK3CA/CD3D/TBK1/CASP8/OAS2/MAPK8/STAT5B/TRAF3/CD28/IKBKB/EIF3H/CCNE2/CHUK/SLAMF1/STAT5A	4.9768098867126
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	81/987	480/9376	1.60303951367781	NDUFA13/PSMA2/TUBA4A/BRAF/TUBB2A/CTNNB1/NFKB1/TUBB4B/MAP1LC3B/PSMD9/MT-ATP8/PSMA6/CSNK1E/NDUFB1/NDUFA7/TUBA1A/ATXN1/SQSTM1/IFT57/ULK1/PRNP/PPP3R1/ATXN2L/ATP2A2/UQCRFS1/PSMD12/DERL1/NDUFV2/RAB1A/UBE2J1/SDHA/MAP2K3/CYCS/NDUFB8/UQCRB/CAMK2D/MT-ND4L/NDUFA1/DCTN6/CALM2/NDUFC1/VAPB/NDUFA6/VDAC3/PSMA1/RAB5A/CASP3/UQCRC2/NDUFS5/MAP2K1/TARDBP/FRAT1/TBK1/ERN1/PSMC4/CASP8/PPP3CA/PPP3CC/UQCR11/COX7C/TUBA8/MAP2K7/MAPK8/SOD1/AXIN1/COX7B/RPS27A/PSMC6/NDUFC2/FRAT2/OPTN/CAPN2/CSNK1A1/UBC/TANK/CALM3/VDAC1/MAP3K5/ATXN1L/PSMB2/WIPI2	4.65219723431638
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/987	78/9376	2.67934429636557	TOB1/PAN3/DDX6/CNOT6L/PABPC1/CNOT2/TOB2/BTG3/PNPT1/BTG1/PABPC4/CNOT9/TENT4B/CNOT4/EXOSC6/CNOT10/C1D/MTREX/LSM1/CNOT1/LSM4/CNOT7	5.10835877404223
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	29/987	119/9376	2.31500259678339	TNFAIP3/SOCS3/BIRC2/NFKB1/ADAM17/AKT3/BCL3/ITCH/CYLD/MAP3K8/IL18R1/MAP2K3/MAP3K14/CASP3/BIRC3/DNM1L/PIK3CA/MAP2K4/MAP2K1/CASP8/RHBDF2/RPS6KA5/MAP2K7/MAPK8/TRAF3/IKBKB/ICAM1/CHUK/MAP3K5	4.9516971683172
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	68/987	388/9376	1.66485967056268	NDUFA13/PSMA2/TUBA4A/BRAF/IRS2/TUBB2A/CTNNB1/NFKB1/TUBB4B/ADAM17/PSMD9/MT-ATP8/PSMA6/CSNK1E/AKT3/NDUFB1/NDUFA7/EIF2AK2/TUBA1A/ULK1/PPP3R1/ATP2A2/UQCRFS1/PSMD12/NDUFV2/SDHA/CYCS/NDUFB8/UQCRB/MT-ND4L/NDUFA1/CALM2/NDUFC1/NDUFA6/VDAC3/PSMA1/CASP3/UQCRC2/NDUFS5/PIK3CA/MAP2K1/FRAT1/ERN1/PSMC4/CASP8/PPP3CA/PPP3CC/UQCR11/COX7C/TUBA8/MAP2K7/MAPK8/AXIN1/COX7B/PSMC6/NDUFC2/RTN3/NAE1/FRAT2/CAPN2/CSNK1A1/IKBKB/CHUK/CALM3/VDAC1/MAP3K5/PSMB2/WIPI2	4.5877890270474
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	31/987	133/9376	2.21416763793983	BRAF/IRS2/IL7R/TGFB1/SIRT1/S1PR1/SMAD3/BCL2L11/FOXO1/CSNK1E/PLK3/AKT3/SOS2/S1PR4/GABARAP/SOS1/SGK3/CCND2/PIK3CA/MAP2K1/MAPK8/GABARAPL2/FBXO32/CDKN2D/GABARAPL1/IKBKB/PRKAA1/GADD45A/PDPK1/CHUK/STK11	4.83712281647077
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	26/987	105/9376	2.35225551213393	RABGEF1/ARIH1/CCZ1B/MAP1LC3B/CCZ1/SQSTM1/ULK1/GABARAP/TOMM20/HIF1A/RAB5A/SMURF2/TOMM7/BNIP3L/TBK1/OPA1/USP15/MAPK8/RPS27A/GABARAPL2/SIAH1/OPTN/UBC/GABARAPL1/TBC1D15/CITED2	4.77946446214062
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	36/987	169/9376	2.02356072732505	IRS2/MAP1LC3B/PLEKHM1/AKT3/WDR45B/SQSTM1/ULK1/GABARAP/RAB1A/DDIT4/RHEB/HIF1A/PPP2CA/PIK3CA/MAP2K1/TBK1/ERN1/RPS6KB1/RAB33B/ATG3/MAPK8/PRKCQ/RPS27A/RUBCN/GABARAPL2/OPTN/EPG5/SH3GLB1/UBC/GABARAPL1/PRKAA1/TANK/PDPK1/YKT6/STK11/WIPI2	4.60560843981433
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/987	108/9376	2.28691508124132	EEF1A1/NUP98/NUP54/EIF4A3/SUMO1/NUP153/NXT1/NUP58/KPNA4/SENP2/RANBP2/RBM8A/TNPO1/TNPO3/DDX39B/DDX19B/MAGOH/NUP88/NCBP2/KPNA3/KPNA2/XPO4/POM121/RNPS1/ALYREF/SUMO4	4.61379052566204
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	55/987	308/9376	1.69633810971197	NDUFA13/PSMA2/TUBA4A/TUBB2A/POLR2K/POLR2A/TUBB4B/PSMD9/MT-ATP8/POLR2J3/PSMA6/BBC3/AP2B1/NDUFB1/NDUFA7/TUBA1A/IFT57/ULK1/TBPL1/UQCRFS1/PSMD12/POLR2C/NDUFV2/SDHA/CYCS/NDUFB8/UQCRB/MT-ND4L/NDUFA1/DCTN6/NDUFC1/NDUFA6/VDAC3/PSMA1/CASP3/UQCRC2/NDUFS5/ERN1/PSMC4/CASP8/UQCR11/COX7C/TUBA8/MAP2K7/MAPK8/SOD1/COX7B/NRF1/PSMC6/NDUFC2/SLC1A2/VDAC1/MAP3K5/PSMB2/WIPI2	4.26215151219097
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	31/987	142/9376	2.07383306933801	UBE2B/SOCS3/BIRC2/CUL3/UBE2A/UBE2S/CBLB/UBE2Q1/ITCH/UBE2Q2/UBE2F/UBE2J1/UBE2H/ANAPC16/SMURF2/BIRC3/ANAPC1/CUL4A/FBXW7/UBE2E3/SOCS1/UBR5/UBE2M/SKP1/RPS27A/UBE2K/SIAH1/UBC/UBE4A/PPIL2/UBA6	4.42257420580679
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/987	224/9376	1.82356346794037	HLA-C/B2M/NFATC1/TGFB1/NFKB2/NFKB1/RELB/SMAD3/HLA-B/HLA-DQA2/CD3E/AKT3/ZFP36/GPS2/PPP3R1/TBPL1/CRTC2/MAP3K14/ANAPC16/VDAC3/CCND2/ANAPC1/HLA-A/PIK3CA/MAP2K4/MAP2K1/CD3D/PPP3CA/ETS1/PPP3CC/MAPK8/CRTC3/HLA-DPB1/STAT5B/IKBKB/ICAM1/POLB/CCNE2/HLA-DQB1/CHUK/ELK4/STAT5A/VDAC1	4.27909762233738
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	22/987	87/9376	2.40217074846569	BRAF/CTNNB1/TGFB1/SMAD3/BCL2L11/BBC3/AKT3/SOS2/CYCS/MLH1/TCF7/SOS1/CASP3/PIK3CA/MAP2K1/RPS6KB1/RALGDS/MAPK8/AXIN1/LEF1/PMAIP1/GADD45A	4.50676761623656
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	33/987	157/9376	1.99670880684568	HLA-C/PPP1CB/NFATC1/TGFB1/SIRT1/NFKB1/SMAD3/HLA-B/FOXO1/AKT3/SQSTM1/HIPK1/PPP3R1/MAP2K3/CALM2/RHEB/VDAC3/PPP1CC/CCND2/HLA-A/PIK3CA/MAP2K1/PPP3CA/ETS1/PPP3CC/MAPKAPK2/RAD9B/CAPN2/ZFP36L2/CCNE2/GADD45A/CALM3/VDAC1	4.31981682589772
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	49/987	268/9376	1.73684767651106	NDUFA13/PSMA2/TUBA4A/TUBB2A/TUBB4B/PSMD9/MT-ATP8/PSMA6/NDUFB1/NDUFA7/TUBA1A/NFE2L2/UQCRFS1/GNAI3/PSMD12/NDUFV2/UBE2J1/SDHA/CYCS/NDUFB8/UQCRB/CAMK2D/MT-ND4L/NDUFA1/CALM2/NDUFC1/NDUFA6/VDAC3/PSMA1/CASP3/UQCRC2/NDUFS5/ERN1/PSMC4/UQCR11/COX7C/TUBA8/MAPK8/SOD1/COX7B/RPS27A/PSMC6/NDUFC2/UBC/GNAS/CALM3/VDAC1/MAP3K5/PSMB2	4.19780945868951
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/987	227/9376	1.79946351021428	NDUFA13/BRAF/PRKD3/NFKB1/MT-ATP8/AKT3/NDUFB1/NDUFA7/SOS2/NFE2L2/ABL1/UQCRFS1/NDUFV2/SDHA/NDUFB8/UQCRB/MT-ND4L/NDUFA1/PTPRJ/MAP3K14/NDUFC1/HIF1A/NDUFA6/VDAC3/SOS1/UQCRC2/NDUFS5/PIK3CA/MAP2K4/MAP2K1/UQCR11/COX7C/MAP2K7/MAPK8/SOD1/COX7B/NDUFC2/ARNT/IKBKB/PDPK1/CHUK/VDAC1/MAP3K5	4.18228744542968
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/987	90/9376	2.3220983901835	IFNGR1/NFATC1/NFKB1/NFKBIE/CD3E/AKT3/PPP3R1/RASGRP1/MAP2K3/HIF1A/PIK3CA/MAP2K1/EML4/CD3D/PPP3CA/RPS6KB1/PPP3CC/PRKCQ/CD28/IKBKB/CHUK/JAK2	4.32274690792799
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	18/987	68/9376	2.51457178616127	RARA/BRAF/PIM2/PIM1/NFKB1/PER2/AKT3/SOS2/TCF7/SOS1/PIK3CA/MAP2K1/RPS6KB1/LEF1/STAT5B/IKBKB/CHUK/STAT5A	4.29937422783955
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/987	109/9376	2.09163157747971	PPP1CB/IRS2/SOCS3/NFKB1/FOXO1/AKT3/GFPT1/OGT/CRTC2/GFPT2/PRKCE/CPT1A/PPP1CC/PIK3CA/RPS6KB1/MAPK8/NR1H2/MLXIP/PRKCQ/IKBKB/PRKAA1/PDPK1/SREBF1/RPS6KA3	3.93195804139988
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	17/987	66/9376	2.44683921279666	IFNGR1/NFATC1/TGFB1/NFKB1/STAT4/SMAD3/HLA-DQA2/IL18RAP/IL4R/IL23A/IL18R1/GATA3/IL12RB2/MAF/HLA-DPB1/IL21R/HLA-DQB1	4.04581961187875
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	28/987	138/9376	1.92743344639737	PPP1CB/PHKG1/MKNK2/BRAF/IRS2/SOCS3/PDE3B/FOXO1/AKT3/RPS6/SOS2/CBLB/CALM2/RHEB/PPP1CC/SOS1/PIK3CA/MAP2K1/PRKAR1A/RPS6KB1/SOCS1/MAPK8/RAPGEF1/IKBKB/PRKAA1/PDPK1/CALM3/SREBF1	3.76463118572681
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	33/987	173/9376	1.81204209638597	IFNGR1/SOCS3/MX1/MX2/IRF7/NFKB1/NUP98/HNRNPUL1/HLA-DQA2/AKT3/EIF2AK2/NXT1/IFIH1/IRF9/CYCS/CASP3/PIK3CA/MAP2K1/DNAJC3/TBK1/CASP8/OAS2/HLA-DPB1/CASP1/TNFRSF10B/TRAF3/KPNA2/IKBKB/ICAM1/HLA-DQB1/CHUK/JAK2/VDAC1	3.69765171011429
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/987	56/9376	2.54450716456796	B4GALT1/MGAT4A/KRTCAP2/MGAT2/ALG13/STT3B/ALG6/RPN2/TMEM258/RPN1/MGAT5/MGAT1/DHRSX/MGAT4B/MAN2A1	3.97617144314678
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	28/987	142/9376	1.87313954649885	IFNGR1/JUND/SOCS3/PLCG2/NFATC1/TGFB1/NFKB2/NFKB1/RELB/AKT3/SQSTM1/CYLD/PPP3R1/IRF9/ATP2A2/TMEM64/MAP3K14/FYN/PIK3CA/MAP2K1/FOSL2/PPP3CA/SOCS1/PPP3CC/MAP2K7/MAPK8/IKBKB/CHUK	3.59601929450373
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	31/987	163/9376	1.80665212175459	BRAF/NFATC1/TGFB1/IRF7/NFKB1/STAT4/SMAD3/AKT3/SOS2/IFIH1/YWHAQ/MAP2K3/CYCS/DDX3X/VDAC3/SOS1/CASP3/PIK3CA/MAP2K4/MAP2K1/TBK1/CASP8/MAP2K7/MAPK8/STAT5B/TRAF3/IKBKB/CCNE2/CHUK/JAK2/STAT5A	3.56343354867547
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	38/987	214/9376	1.68682593339583	HLA-C/B2M/CXCR4/PLCG2/NFATC1/TAP1/NFKB1/HLA-B/CD3E/AP1S2/AKT3/PPP3R1/GNG2/GNAI3/MAP2K3/CYCS/TAP2/CALM2/CASP3/HLA-A/PIK3CA/MAP2K1/CD3D/AP1G1/CUL4A/TBK1/CASP8/PPP3CA/RPS6KB1/PPP3CC/TAPBP/MAP2K7/SKP1/MAPK8/IKBKB/CHUK/CALM3/BST2	3.48616184472408
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	30/987	157/9376	1.81518982440517	NFATC1/GPR132/TGFB1/SLC16A1/ODC1/DUSP8/SIRT1/S1PR1/ADAM17/DUSP16/CD47/ATP2A2/UQCRFS1/CPT1A/CAMK2D/ATP11B/HIF1A/RAB5A/CASP3/PTGER2/MAP2K1/ELMO1/MAPKAPK2/NR1H2/CASP1/ATP8A1/ARNT/ITGAV/PANX1/JAK2	3.53309883045035
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/987	137/9376	1.87216293568212	TUBA4A/BIRC2/LMNA/NFKB1/BCL2L11/BBC3/AKT3/TUBA1A/CYCS/MCL1/MAP3K14/CASP3/BIRC3/PIK3CA/MAP2K1/ERN1/CASP8/TUBA8/MAPK8/TNFRSF10B/CAPN2/IKBKB/PMAIP1/GADD45A/PDPK1/CHUK/MAP3K5	3.52723620706485
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/987	44/9376	2.59077093119646	B4GALT1/MGAT4A/KRTCAP2/MGAT2/ALG13/STT3B/RPN2/TMEM258/RPN1/MGAT1/MGAT4B/MAN2A1	3.62773651866891
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/987	275/9376	1.55446255871788	NDUFA13/PSMA2/TUBA4A/TUBB2A/TUBB4B/PSMD9/MT-ATP8/PSMA6/NDUFB1/NDUFA7/TUBA1A/PRNP/PPP3R1/UQCRFS1/PSMD12/NDUFV2/SDHA/CYCS/NDUFB8/UQCRB/MT-ND4L/NDUFA1/NDUFC1/NDUFA6/VDAC3/PSMA1/CASP3/UQCRC2/FYN/HSPA8/NDUFS5/PIK3CA/PSMC4/PPP3CA/PPP3CC/UQCR11/COX7C/TUBA8/MAPK8/SOD1/COX7B/PSMC6/NDUFC2/VDAC1/PSMB2	3.20098126203321
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/987	34/9376	2.7939686512903	BHLHE40/CRY1/NR1D2/CSNK1E/PER2/PER1/CSNK1D/SKP1/PRKAA1/FBXL3	3.59437590323365
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	27/987	144/9376	1.78115501519757	TRA2A/CTNNB1/SIRT1/NFKB1/ADIPOR2/FOXO1/AKT3/MAP2K3/CPT1A/MAP3K14/TCF7/CASP3/MAP2K4/TBK1/CASP8/MAP2K7/MAPK8/LEF1/TRAF3/LPIN2/IKBKB/ALDH7A1/PRKAA1/CHUK/MAP3K5/SREBF1/ALDH9A1	3.24010952503748
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	24/987	125/9376	1.82390273556231	PPP2R5C/NFKB1/S1PR1/AKT3/PPP2R5A/S1PR4/GNAI3/PPP2R3C/PRKCE/PPP2R2D/FYN/PPP2CA/PIK3CA/MAP2K1/DEGS1/MAPK8/SGMS1/SPTLC1/PDPK1/PPP2R2B/SGPP1/MAP3K5/NSMAF/PPP2R3A	3.18072211299755
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	41/987	250/9376	1.55791691995947	HLA-C/CXCR4/ARF4/SMAP2/EHD4/SMAD3/HLA-B/ARPC1B/ARF6/AP2B1/CYTH2/CBLB/CYTH1/TFRC/SNX3/SNX2/ITCH/CHMP4B/CHMP1B/IST1/ARAP2/EPS15/ARFGAP3/RAB5A/SMURF2/HSPA8/HLA-A/CHMP5/WASHC2C/AMPH/PDCD6IP/SH3GLB1/WIPF1/CAPZA1/RAB11FIP4/VPS37A/RAB4A/RAB22A/WASHC1/GRK2/DNM2	3.06682095413697
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	35/987	205/9376	1.62186472928559	NDUFA13/PPP1CB/TGFB1/NFKB1/SMAD3/MT-ATP8/AKT3/NDUFB1/NDUFA7/GFPT1/ATP2A2/UQCRFS1/NDUFV2/GFPT2/SDHA/NDUFB8/UQCRB/CAMK2D/MT-ND4L/NDUFA1/NDUFC1/NDUFA6/VDAC3/PPP1CC/UQCRC2/NDUFS5/PIK3CA/MPC2/UQCR11/COX7C/MAPK8/COX7B/NDUFC2/VDAC1/PDK3	3.08783173610712
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	22/987	112/9376	1.86597192068317	IFNGR1/BIRC2/TGFB1/NFKB1/HLA-DQA2/AKT3/GNAI3/MAP2K3/CYCS/CASP3/BIRC3/HSPA8/CASP8/SOCS1/PIK3R5/MAPK8/HLA-DPB1/IKBKB/HLA-DQB1/PDPK1/CHUK/JAK2	3.16229706984004
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	25/987	133/9376	1.78561906285471	HLA-C/IFNGR1/BRAF/PLCG2/NFATC1/HLA-B/KLRC3/SOS2/PPP3R1/CD48/SOS1/CASP3/FYN/HLA-A/PIK3CA/MAP2K1/PPP3CA/PPP3CC/KLRK1/ICAM2/TNFRSF10B/MICA/MICB/ICAM1/KIR3DL2	3.12982801982504
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	23/987	120/9376	1.82073623775751	BRAF/PLCG2/NFKB1/NFKBIE/AKT3/SOS2/ABL1/CAMK2D/CALM2/SOS1/PIK3CA/MAP2K1/RPS6KA5/MAPKAPK2/MAP2K7/RIPK2/MAPK8/RAPGEF1/IKBKB/PDPK1/CALM3/MAP3K5/RPS6KA3	3.10364240168038
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	18/987	86/9376	1.98826606347636	BRAF/PLCG2/AKT3/SOS2/CBLB/ABL1/NCK2/CAMK2D/SOS1/PIK3CA/MAP2K4/MAP2K1/RPS6KB1/MAP2K7/MAPK8/STAT5B/NCK1/STAT5A	3.15794359114297
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	32/987	187/9376	1.62558176075072	TNFAIP3/BIRC2/IRF7/NFKB1/MAP1LC3B/GABARAP/NLRP1/IRF9/VDAC3/BIRC3/DNM1L/GBP4/TBK1/CASP8/OAS2/RIPK2/MAPK8/NEK7/CASP1/GPSM3/GABARAPL2/PKN1/TRAF3/TRPV2/GABARAPL1/IKBKB/TANK/CARD8/SUGT1/PANX1/CHUK/VDAC1	2.96387492767693
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/987	122/9376	1.79088810271231	IRS2/PPP2R5C/SIRT1/ADIPOR2/FOXO1/AKT3/PPP2R5A/HMGCR/ULK1/CRTC2/PPP2R3C/CPT1A/PPP2R2D/RHEB/PPP2CA/PIK3CA/RPS6KB1/PRKAA1/PDPK1/PPP2R2B/STK11/SREBF1/PPP2R3A	3.01591659943334
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	26/987	144/9376	1.71518631093099	PSMA2/GTF2B/PSMD9/PSMA6/AKT3/ATXN1/PUM2/ULK1/ATXN2L/TBPL1/ATP2A2/PSMD12/CYCS/VDAC3/PSMA1/PIK3CA/ERN1/PSMC4/OPA1/MAPK8/PSMC6/VDAC1/MAP3K5/ATXN1L/PSMB2/WIPI2	2.96648159858237
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/987	32/9376	2.67173252279635	BIRC2/BCL2L11/BBC3/CYCS/CASP3/BIRC3/CASP8/MAPK8/PMAIP1	3.24911051126312
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/987	56/9376	2.20523954262556	EEF1A1/NFKB2/NFKB1/SEC22B/RAB1A/SAR1A/CYCS/CASP3/HSPA8/CASP8/CLK4/CASP1/SAR1B	3.10276259086151
Genetic Information Processing	Transcription	hsa03040	Spliceosome	39/987	243/9376	1.52461005416088	TRA2A/SRSF6/PHF5A/HNRNPA1/SRSF5/DDX5/BCAS2/EIF4A3/WBP11/BUD31/SNIP1/SRSF3/CWC25/DHX8/RBMX/SRSF2/SNU13/PRPF18/RBM8A/HSPA8/SRSF1/DDX39B/SNRNP27/SART1/SNRPA1/MAGOH/DHX15/SNRPF/NCBP2/SRSF7/SF3B6/SNRPB2/CRNKL1/PRPF38A/PLRG1/SNRPG/TXNL4A/LSM4/ALYREF	2.84198731338078
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	15/987	70/9376	2.03560573165436	IRS2/SOCS3/NFKB1/NFKBIE/ADIPOR2/ACSL3/AKT3/CPT1A/MAPK8/PRKCQ/IKBKB/PRKAA1/CHUK/JAK2/STK11	2.98298492546079
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/987	77/9376	1.97392070948302	BRAF/TGFB1/NFKB1/SMAD3/AKT3/SOS2/ABL1/SOS1/PIK3CA/MAP2K1/STAT5B/IKBKB/BCR/GADD45A/CHUK/STAT5A	2.94333677614623
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/987	333/9376	1.42635036252058	HLA-C/CTNNB1/PPP2R5C/MX1/OASL/MX2/NFKB1/HLA-B/LFNG/FOXO1/AKT3/PPP2R5A/EIF2AK2/SOS2/LLGL1/HES4/TBPL1/ITGA5/IRF9/PPP2R3C/PPP2R2D/TCF7/RHEB/SOS1/CASP3/CCND2/HLA-A/PPP2CA/PIK3CA/MAP2K1/TBK1/CASP8/RPS6KB1/UBR4/MFNG/MAML1/ISG15/AXIN1/ATP6V1A/ATP6V1G1/TRAF3/CSNK1A1/GNAS/IKBKB/CCNE2/ITGAV/PPP2R2B/ITGA4/CHUK/PPP2R3A	2.71719999590274
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	35/987	216/9376	1.53926976622012	NFATC1/IRF7/NFKB1/AKT3/NFE2L2/CCL3L1/PPP3R1/MAP2K3/CYCS/CAMK2D/CALM2/CASP3/HSPA8/ABCG1/PIK3CA/MAP2K4/TBK1/ERN1/CASP8/PPP3CA/PPP3CC/MAP2K7/MAPK8/CASP1/TNFRSF10B/TRAF3/IKBKB/TANK/ICAM1/HSPA4/PDPK1/CHUK/JAK2/CALM3/MAP3K5	2.75026364875433
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	27/987	156/9376	1.6441430909516	BRAF/SOCS3/CTNNB1/MX1/MX2/IRF7/NFKB1/AKT3/EIF2AK2/SOS2/YWHAQ/IRF9/CYCS/PPP2R2D/SOS1/CASP3/PPP2CA/PIK3CA/MAP2K1/TBK1/EIF3E/CASP8/OAS2/TRAF3/IKBKB/PPP2R2B/CHUK	2.7827123079935
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/987	72/9376	1.9790611279973	RNF125/IRF7/NFKB1/IFIH1/CYLD/DDX3X/TBK1/CASP8/ISG15/MAPK8/OTUD5/TRAF3/IKBKB/TANK/CHUK	2.8604234031724
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/987	59/9376	2.09310871842426	BRAF/CTNNB1/AKT3/SOS2/MLH1/TCF7/SOS1/PIK3CA/MAP2K1/AXIN1/LEF1/GADD45A/PDPK1	2.8889527150059
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/987	73/9376	1.95195070158638	CXCR4/MX1/ELL2/MX2/NUP153/NELFE/CHMP4B/RANBP2/FURIN/TNPO3/MDFIC/PDCD6IP/CCNT1/ELL/BST2	2.80061554584815
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/987	253/9376	1.464348787198	CD44/PLCG2/NFKB1/MAP1LC3B/FOXO1/ARPC1B/ARF6/GLMN/AKT3/CYTH2/SQSTM1/CYTH1/UBE2V1/TNIP1/ITGA5/CAST/MALT1/CYCS/PRKCE/PIK3CA/TBK1/RPS6KB1/ELMO1/RPS6KA5/RIPK2/SKP1/MAPK8/PRKCQ/RPS27A/FNBP1/CASP1/ARHGEF2/CAPN2/UBC/IKBKB/BCL10/CHUK/VDAC1/WIPI2	2.56817643147497
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/987	75/9376	1.89989868287741	BIRC2/BBC3/AKT3/POLH/CYCS/MLH1/CASP3/BIRC3/PIK3CA/ATP7A/CASP8/PMAIP1/PDPK1/XPA/MAP3K5	2.6837900782771
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/987	31/9376	2.45148217145472	SRP19/SRP9/SEC61G/SPCS3/TMEM208/SRP54/SEC63/SEC61B	2.77646381099097
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/987	63/9376	1.96021292677828	GTF2H2/POLD4/POLR2K/POLR2A/POLR2J3/CCNH/GTF2H2C/POLR2C/CUL4A/RAD23B/POLR2M/RPA3/XPA	2.62290245080857
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/987	70/9376	1.89989868287741	HLA-C/CD55/HLA-B/HLA-DQA2/ABL1/CYCS/CASP3/FYN/HLA-A/CASP8/HLA-DPB1/CD28/ICAM1/HLA-DQB1	2.59209091202794
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/987	227/9376	1.46467960133721	HLA-C/B2M/CXCR4/CTNNB1/NFATC1/TAP1/NFKB1/HLA-B/AKT3/SOS2/CCL3L1/PPP3R1/GNG2/GNAI3/CYCS/TAP2/CALM2/RHEB/SOS1/CASP3/PTGER2/HLA-A/PIK3CA/MAP2K1/TBK1/CASP8/PPP3CA/RPS6KB1/PPP3CC/TAPBP/GNAS/IKBKB/ITGAV/CHUK/CALM3	2.43090977635611
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/987	91/9376	1.77463063785252	IFITM1/PLCG2/NFATC1/NFKB1/NFKBIE/AKT3/SOS2/PPP3R1/MALT1/SOS1/PIK3CA/MAP2K1/PPP3CA/PPP3CC/IKBKB/BCL10/CHUK	2.54690959462805
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	36/987	235/9376	1.45524154433163	NDUFA13/COX19/MT-ATP8/ACSL3/RPS6/NDUFB1/NDUFA7/SOS2/SLC25A29/UQCRFS1/NDUFV2/SDHA/MAP2K3/CPT1A/NDUFB8/UQCRB/MT-ND4L/NDUFA1/RHEB/NDUFC1/NDUFA6/SOS1/UQCRC2/NDUFS5/RPS6KB1/UQCR11/COX7C/COX7B/NDUFC2/ZNF516/GNAS/PNPLA2/PRKAA1/NDUFAF5/MAP3K5/RPS6KA3	2.42419796288663
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	14/987	71/9376	1.87313954649885	SOCS3/NFKB1/AKT3/SOS2/ESR2/SOS1/CCND2/PIK3CA/MAP2K1/SOCS1/MAPK8/STAT5B/JAK2/STAT5A	2.53304999643414
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/987	38/9376	2.24988001919693	IL7R/TAP1/CD3E/CD8A/ORAI1/TAP2/CD3D/ICOS/ADA	2.64802637368391
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/987	138/9376	1.58324890239784	NFATC1/NFKB1/ARPC1B/ARF6/AKT3/CD8A/ITGA5/MAP2K3/PIK3CA/MAP2K4/MAP2K1/TBK1/ELMO1/MAP2K7/MAPK8/CASP1/PKN1/WIPF1/IKBKB/ITGA4/CHUK/ARHGEF7/RPS6KA3	2.36751975630935
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/987	46/9376	2.06510726399718	PSMA2/PSMB10/PSMD9/PSMA6/PSME4/PSMD12/PSMA1/PSMC4/PSMC6/PSMB2	2.4838225057217
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/987	155/9376	1.5321763571592	HLA-C/TUBA4A/TUBB2A/TAP1/TUBB4B/HLA-B/HLA-DQA2/SEC22B/TUBA1A/TFRC/ITGA5/TAP2/SEC61G/RAB5A/DYNC1H1/HLA-A/TUBA8/VAMP3/HLA-DPB1/ATP6V1A/ATP6V1G1/SEC61B/HLA-DQB1/ITGAV/M6PR	2.29150881262526
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/987	103/9376	1.66010564523269	IFNGR1/TGFB1/NFKB1/CD3E/AKT3/CCL3L1/GNAI3/PPP2R2D/PPP2CA/PIK3CA/MAP2K4/CD3D/CASP8/MAPK8/GNAS/IKBKB/PPP2R2B/CHUK	2.31052699341154
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	43/987	300/9376	1.36159405606214	JUND/MKNK2/BRAF/NFATC1/TGFB1/NFKB2/DUSP8/DUSP10/NFKB1/RELB/AKT3/SOS2/DUSP16/MAP3K8/PPP3R1/RASA2/RASGRP1/MAP2K3/FLT3LG/MAP3K14/SOS1/CASP3/HSPA8/MAP2K4/MAP2K1/MAPK8IP1/PPP3CA/PPP3CC/RPS6KA5/MAPKAPK2/MAP2K7/MAPK8/FGF9/IKBKB/CDC25B/GADD45A/LAMTOR3/NF1/CHUK/MAX/ELK4/MAP3K5/RPS6KA3	2.1833521289266
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/987	157/9376	1.5126581870043	PPP1CB/SMAD7/CTNNB1/BIRC2/TGFB1/SMAD3/CSNK1E/BBC3/LLGL1/LATS2/YWHAQ/PPP2R2D/MOB1A/TCF7/PPP1CC/BIRC3/CCND2/PPP2CA/CSNK1D/ID1/AXIN1/LEF1/PPP2R2B/TP53BP2/SAV1	2.2219021713714
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/987	82/9376	1.73771220994885	HLA-C/B2M/TAP1/HLA-B/HLA-DQA2/KLRC3/CD8A/TAP2/HSPA8/HLA-A/TAPBP/HLA-DPB1/KIR3DL2/HLA-DQB1/HSPA4	2.30134474234825
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/987	75/9376	1.77323877068558	BBC3/CYCS/CCNG1/CASP3/CCND2/CASP8/RRM2B/GORAB/SIAH1/TNFRSF10B/PMAIP1/CCNE2/PPM1D/GADD45A	2.30604909240416
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	26/987	168/9376	1.47015969508371	IFNGR1/TNFAIP3/BIRC2/STAT4/EIF2AK2/SQSTM1/CYLD/IRF9/CHMP4B/CHMP1B/CAMK2D/SPATA2/VDAC3/BIRC3/DNM1L/CASP8/CHMP5/MAPK8/CASP1/ZBP1/STAT5B/TNFRSF10B/CAPN2/JAK2/STAT5A/VDAC1	2.10914529718208
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/987	107/9376	1.59804562111184	PHKG1/SIK1/LDHA/PDE3B/SIRT1/FOXO1/AKT3/SIK2/PPP3R1/CRTC2/CPT1A/CAMK2D/CALM2/PPP3CA/PPP3CC/GNAS/PRKAA1/CALM3	2.13402193906181
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/987	138/9376	1.51441199359793	NDUFA13/MT-ATP8/NDUFB1/NDUFA7/UQCRFS1/NDUFV2/SDHA/CYCS/NDUFB8/UQCRB/MT-ND4L/NDUFA1/NDUFC1/NDUFA6/UQCRC2/NDUFS5/UQCR11/COX7C/COX7B/NDUFC2/ATP6V1A/ATP6V1G1	2.08809747042586
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/987	93/9376	1.63432144763648	CKS2/BIRC2/NFKB1/TRAF4/AKT3/CYCS/CASP3/BIRC3/PIK3CA/TRAF3/IKBKB/CCNE2/GADD45A/ITGAV/CHUK/MAX	2.10860781784858
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	27/987	178/9376	1.44093439431713	CTNNB1/NFATC1/SIRT1/SMAD3/TLE1/CSNK1E/SENP2/PPP3R1/CAMK2D/TCF7/CCND2/RYK/TLE4/FRAT1/PPP3CA/PPP3CC/ROR2/SKP1/MAPK8/AXIN1/LEF1/SIAH1/FRAT2/CSNK1A1/BAMBI/DAAM1/TLE3	2.03716587404427
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/987	37/9376	2.05394452202963	BRAF/CTNNB1/TFG/TCF7/MAP2K1/CCDC6/LEF1/GADD45A	2.20321836281492
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	30/987	205/9376	1.39016976795908	HLA-C/GTF2H2/GTF2B/NFKB2/IRF7/NFKB1/HLA-B/GTF2H2C/EIF2AK2/HDAC4/YWHAQ/TBPL1/RASA2/IRF9/DDX3X/REL/VDAC3/CASP3/CCND2/HLA-A/PIK3CA/CASP8/UBR4/MAPKAPK2/STAT5B/TRAF3/PMAIP1/POLB/CCNE2/STAT5A	1.93736440617506
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	24/987	158/9376	1.44296102497018	SLC7A5/BRAF/SLC3A2/AKT3/RPS6/SOS2/ULK1/DDIT4/EIF4B/RHEB/SOS1/PIK3CA/MAP2K1/RPS6KB1/ATP6V1A/ATP6V1G1/LPIN2/IKBKB/PRKAA1/PDPK1/LAMTOR3/CHUK/STK11/RPS6KA3	1.92603788026928
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/987	105/9376	1.53801321947219	TNFAIP3/PLCG2/BIRC2/NFKB2/NFKB1/RELB/CYLD/MALT1/MAP3K14/BIRC3/PRKCQ/TRAF3/IKBKB/BCL10/ICAM1/GADD45A/CHUK	1.90157484259121
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/987	14/9376	2.71414097553915	B4GALT1/B3GNT7/B3GNT2/ST3GAL1	2.20148308728239
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/987	33/9376	2.01504405759725	SEC22B/VTI1A/BET1/STX11/VAMP3/STX5/YKT6	2.00349289160877
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/987	138/9376	1.44557508479803	PPP1CB/PPP2R5C/STAG3/PPP2R5A/YWHAQ/PPP3R1/REC8/CAMK2D/CALM2/ANAPC16/PPP1CC/ANAPC1/PPP2CA/MAP2K1/CPEB2/PPP3CA/PPP3CC/SKP1/CCNE2/CALM3/RPS6KA3	1.80867518454236
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/987	69/9376	1.65208581119774	PLCG2/AKT3/SOS2/MAP2K3/SOS1/FYN/PIK3CA/MAP2K4/MAP2K1/MAP2K7/MAPK8/PDPK1	1.8647196880198
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/987	77/9376	1.60381057645495	BRAF/TGFB1/NFKB1/SMAD3/AKT3/PIK3CA/MAP2K1/RPS6KB1/RALGDS/MAPK8/IKBKB/GADD45A/CHUK	1.82480756205432
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	16/987	100/9376	1.51991894630193	CD44/CD2/IL7R/CD55/HLA-DQA2/CD3E/IL4R/TFRC/CD8A/ITGA5/FLT3LG/CD3D/HLA-DPB1/HLA-DQB1/ITGA4/CD5	1.7928517982583
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	16/987	101/9376	1.50487024386329	PLCG2/NFATC1/TGFB1/PIM1/NFKB1/SMAD3/FOXO1/AKT3/PRKCE/CASP3/PIK3CA/MAPK8/STAT5B/ICAM1/JAK2/STAT5A	1.74973637342173
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/987	109/9376	1.48157236738146	IRF7/NFKB1/AKT3/CCL3L1/MAP3K8/IRF9/MAP2K3/PIK3CA/MAP2K4/MAP2K1/TBK1/CASP8/MAP2K7/MAPK8/TRAF3/IKBKB/CHUK	1.73458003735396
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	23/987	158/9376	1.38283764892976	PPP2R5C/TGFB1/SMAD3/CCNH/CDC14A/PPP2R5A/TFDP1/YWHAQ/DBF4/ABL1/ANAPC16/CCND2/ANAPC1/PPP2CA/SKP1/ORC4/CDKN2D/CDC25B/CCNE2/MAU2/GADD45A/STAG2/TFDP2	1.66461555817824
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	17/987	110/9376	1.468103527678	SKIL/SMAD7/TGFB1/TGIF2/SMAD3/SKI/TFDP1/TFRC/TGIF1/SMURF2/PPP2CA/RPS6KB1/ID1/SKP1/NRROS/BAMBI/LEMD3	1.69387448407754
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	22/987	150/9376	1.3932590341101	BRAF/CTNNB1/TGFB1/SMAD3/AKT3/SOS2/ABCB1/MLH1/TCF7/SOS1/PIK3CA/MAP2K1/FRAT1/RPS6KB1/REG4/AXIN1/LEF1/FRAT2/FGF9/CSNK1A1/CCNE2/GADD45A	1.66535463432018
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/987	142/9376	1.40485465987414	CTNNB1/NFKB1/AKT3/SUMO1/SQSTM1/NFE2L2/CALM2/PIK3CA/MAP2K4/MAP2K7/MAPK8/ARHGEF2/IKBKB/PRKAA1/ICAM1/ITGAV/CHUK/CALM3/MAP3K5/PLAT/SUMO4	1.66739116812992
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/987	42/9376	1.8094273170261	PCBP2/MAP1LC3B/ACSL3/SLC3A2/TFRC/PRNP/VDAC3/GPX4	1.80325739300034
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/987	200/9376	1.32992907801418	TUBA4A/TUBB2A/NFKB1/TUBB4B/ARPC1B/ARF6/CYTH2/TUBA1A/CYTH1/ABL1/NCK2/RAB1A/CYCS/SEC24A/CASP3/FYN/CASP8/TUBA8/MAPK8/CASP1/EZR/TNFRSF10B/ARHGEF2/WIPF1/IKBKB/CHUK/F2R/NCK1	1.61770007684253
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/987	50/9376	1.70990881458967	CXCR4/TGFB1/HLA-DQA2/MAP3K14/ICOS/HLA-DPB1/CD28/HLA-DQB1/ITGA4	1.7263505304942
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/987	73/9376	1.5615605612691	BRAF/PLCG2/AKT3/SOS2/SOS1/PIK3CA/MAP2K1/EML4/STAT5B/GADD45A/PDPK1/STAT5A	1.6520973567272
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/987	154/9376	1.35707048776958	PPP1CB/PPP2R5C/CREM/ATP2B1/AKT3/PPP2R5A/ATP1B3/ATP1A1/ATP2A2/GNAI3/PPP2R3C/CAMK2D/PPP2R2D/CALM2/PPP1CC/PPP2CA/PIK3R5/RPS6KA5/GNAS/PPP2R2B/CALM3/PPP2R3A	1.53246609802491
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/987	106/9376	1.43388579839804	BRAF/CTNNB1/NFKB1/FOXO1/AKT3/SOS2/TCF7/SOS1/PIK3CA/MAP2K1/LEF1/IKBKB/CCNE2/PDPK1/CHUK/PLAT	1.54091122294437
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/987	67/9376	1.55961832176504	PPP1CB/BRAF/PPP3R1/CAMK2D/CALM2/PPP1CC/MAP2K1/PPP3CA/PPP3CC/CALM3/RPS6KA3	1.57676484420237
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	25/987	181/9376	1.31208472574407	IFNGR1/TGFB1/NFKB1/HLA-DQA2/PLK3/AKT3/PPP3R1/IL23A/MALT1/CYCS/CAMK2D/CALM2/RAB5A/CASP3/CASP8/PPP3CA/PPP3CC/RIPK2/MAPK8/HLA-DPB1/CEBPG/BCL10/HLA-DQB1/JAK2/CALM3	1.45420305153609
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/987	45/9376	1.68879882922436	HLA-C/HLA-B/HLA-DQA2/HLA-A/HLA-DPB1/CD28/KIR3DL2/HLA-DQB1	1.58863336597315
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/987	31/9376	1.83861162859104	HIBCH/DPYD/CSAD/ALDH7A1/CNDP2/ALDH9A1	1.60413602319734
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/987	166/9376	1.31619487066808	PPP1CB/IRS2/NFATC1/PDE3B/ATP2B1/AKT3/ATP1B3/ATP1A1/PPP3R1/ATP2A2/GNAI3/PRKCE/CALM2/VDAC3/PPP1CC/MAP2K1/ADRA2B/PPP3CA/PIK3R5/PPP3CC/MEF2D/CALM3/VDAC1	1.40983460646735
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/987	133/9376	1.35707048776958	PPP1CB/PPP2R5C/AKT3/PPP2R5A/GNG2/GNAI3/PPP2R3C/CAMK2D/PPP2R2D/CALM2/PPP1CC/PPP2CA/PPP3CA/PPP3CC/MAPK8/GNAS/PPP2R2B/CALM3/PPP2R3A	1.42253322317931
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/987	39/9376	1.70503727950536	HLA-C/HLA-B/HLA-DQA2/HLA-A/HLA-DPB1/CD28/HLA-DQB1	1.51331669328626
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/987	62/9376	1.5321763571592	ADAM17/TLE1/LFNG/ATXN1/ITCH/TLE4/MFNG/MAML1/ATXN1L/TLE3	1.44202377797879
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/987	110/9376	1.38174449663811	IFNGR1/ALDOA/MKNK2/PLCG2/LDHA/PGK1/NFKB1/AKT3/RPS6/TFRC/CAMK2D/HIF1A/PIK3CA/MAP2K1/RPS6KB1/ARNT	1.3813766059399
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/987	168/9376	1.30052588411251	IFNGR1/SOCS3/IL7R/PIM1/STAT4/AKT3/SOS2/IL4R/IRF9/IL23A/MCL1/IL27RA/SOS1/CCND2/PIK3CA/IL12RB2/SOCS1/IL21R/STAT5B/IL24/JAK2/CLCF1/STAT5A	1.34816480822444
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/987	32/9376	1.78115501519757	GABARAP/PPP2CA/ATG3/GABARAPL2/GABARAPL1/WIPI2	1.5182207298084
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/987	70/9376	1.49277753654653	BRAF/TGFB1/AKT3/SOS2/HIF1A/SOS1/PIK3CA/MAP2K1/ETS1/RAPGEF1/ARNT	1.41940887172939
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/987	71/9376	1.47175250082053	PLCG2/NFKB1/ADAM17/MAP3K14/CASP3/MAP2K4/MAPK8/ATP6V1A/ATP6V1G1/IKBKB/CHUK	1.36859299903764
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/987	80/9376	1.42492401215805	BRAF/PLCG2/BCL2L11/AKT3/RPS6/SOS2/SOS1/PIK3CA/MAP2K1/RPS6KB1/NF1/JAK2	1.30917386456177
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/987	49/9376	1.55093770030809	B4GALT1/LFNG/GALNT11/OGT/GALNT3/B3GLCT/MFNG/C1GALT1	1.32622942955187
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/987	122/9376	1.32369990200475	IRS2/SOCS3/PLCG2/AKT3/SOS2/GNAI3/MAP2K3/SOS1/PIK3CA/MAP2K4/MAP2K1/SOCS1/MAPK8/STAT5B/GNAS/JAK2/STAT5A	1.23437424882618
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/987	34/9376	1.67638119077418	POLR2K/POLR2A/POLR2J3/POLR2C/POLR1D/POLR2M	1.35518993142416
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/987	50/9376	1.51991894630193	AMD1/ODC1/LAP3/OAT/P4HA1/ALDH7A1/CNDP2/ALDH9A1	1.26433470090256
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/987	99/9376	1.34336270506483	PPP1CB/PLCG2/MAP2K3/PRKCE/CAMK2D/CALM2/PPP1CC/PTGER2/PIK3CA/MAPK8/PRKCQ/TRPV2/GNAS/CALM3	1.17802920695315
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/987	99/9376	1.34336270506483	GPCPD1/AKT3/SOS2/RHEB/HIF1A/SOS1/PIK3CA/MAP2K1/RPS6KB1/RALGDS/MAPK8/DGKA/PDPK1/CHKB	1.17802920695315
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/987	59/9376	1.44907526660141	UPP1/CMPK1/DPYD/NT5C3B/NT5C3A/NME2/RRM2B/CMPK2/CTPS1	1.18685103212818
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/987	117/9376	1.29907602248028	MORF4L2/BRD7/MORF4L1/ING3/PHF10/EPC2/BCL7C/BCL7B/EPC1/INO80D/INO80B/SS18/GATAD2B/ARID2/SMARCA5/CHRAC1	1.11655880924233
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/987	76/9376	1.37492667839812	BRAF/PLCG2/AKT3/SOS2/CAMK2D/CALM2/SOS1/PIK3CA/MAP2K1/GADD45A/CALM3	1.12564328135265
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/987	44/9376	1.51128304319794	GTF2H2/GTF2B/TAF13/CCNH/GTF2H2C/TAF11/TBPL1	1.16597564791449
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/987	44/9376	1.51128304319794	HLA-C/HLA-B/HLA-DQA2/HLA-A/HLA-DPB1/CD28/HLA-DQB1	1.16597564791449
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/987	44/9376	1.51128304319794	DCTN6/AQP3/RAB5A/DYNLL2/DYNC1H1/GNAS/NSF	1.16597564791449
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/987	60/9376	1.42492401215805	PLCG2/AKT3/PPP3R1/SH2D2A/PIK3CA/MAP2K1/PPP3CA/PPP3CC/MAPKAPK2	1.13256014865085
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	22/987	170/9376	1.22934620656773	BRAF/CTNNB1/PLCG2/TGFB1/SMAD3/BRD7/AKT3/SOS2/NFE2L2/PHF10/TCF7/SOS1/PIK3CA/MAP2K1/FRAT1/RPS6KB1/AXIN1/LEF1/FRAT2/ARID2/CSNK1A1/GADD45A	1.03506983932204
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/987	69/9376	1.37673817599812	PDE3B/PPP3R1/ORAI1/GNAI3/CALM2/PTGER2/PPP3CA/PPP3CC/GNAS/CALM3	1.07732921334693
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/987	69/9376	1.37673817599812	PPP1CB/SIRT1/PPP3R1/CAMK2D/CALM2/PPP1CC/PPP3CA/PPP3CC/GNAS/CALM3	1.07732921334693
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/987	22/9376	1.72718062079764	ALDH7A1/CNDP2/CARNMT1/ALDH9A1	1.1712350797012
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/987	62/9376	1.37895872144328	IRS2/SIRT1/FOXO1/AKT3/HSPA8/PIK3CA/RPS6KB1/SOD1/PRKAA1	1.02685412428079
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	25/987	201/9376	1.18152903164018	RARA/NR4A3/BIRC2/NFKB1/DDX5/FOXO1/PER2/KDM6A/KLF3/SUPT3H/REL/NFKBIZ/BIRC3/SS18/CCND2/MAF/BCL11B/CCNT1/JMJD1C/GADD45A/MLF1/MAX/ELK4/ETV6/PLAT	0.892339670067203
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/987	140/9376	1.22136343899262	PDE3B/MAP1LC3B/SMAD3/AKT3/RPS6/HDAC4/GNG2/GNAI3/PRKCE/CALM2/MAP2K1/RPS6KB1/PIK3R5/NRF1/PRKAA1/MEF2D/CALM3/PLAT	0.905142727204972
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/987	23/9376	1.65208581119774	IDI1/HMGCR/HMGCS1/MVD	1.07394568803811
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/987	23/9376	1.65208581119774	POLD4/MLH1/PMS2/RPA3	1.07394568803811
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/987	149/9376	1.21134479780774	PLCG2/AGPAT4/ARF6/AKT3/CYTH2/SOS2/CYTH1/RHEB/SOS1/FYN/PIK3CA/MAP2K1/RALGDS/PIK3R5/AGPAT5/GNAS/DGKA/F2R/DNM2	0.891956251073684
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/987	47/9376	1.4148181681002	IRS2/SOCS3/PRKCE/PIK3CA/SOCS1/MAPK8/IKBKB	0.977863574713477
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/987	56/9376	1.35707048776958	CUL3/CSNK1E/SMURF2/CCND2/CSNK1D/CSNK1A1/PTCH2/GRK2	0.919240460148356
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/987	90/9376	1.26659912191827	IRS2/SIRT1/NFKB1/ADIPOR2/FOXO1/AKT3/ULK1/RHEB/PIK3CA/RPS6KB1/PRKAA1/STK11	0.871675314398176
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/987	83/9376	1.25896900672599	POLR2K/IRF7/NFKB1/CASP3/TBK1/CASP8/CASP1/ZBP1/POLR1D/IKBKB/CHUK	0.812826746759381
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/987	362/9376	1.10215116962501	IL7R/PPP2R5C/NFKB1/BCL2L11/AKT3/RPS6/PPP2R5A/SOS2/IL4R/YWHAQ/GNG2/ITGA5/CRTC2/MCL1/PPP2R3C/FLT3LG/DDIT4/EIF4B/PPP2R2D/RHEB/SOS1/SGK3/CCND2/PPP2CA/PIK3CA/MAP2K1/RPS6KB1/PIK3R5/PKN1/FGF9/IKBKB/PRKAA1/CCNE2/ITGAV/PDPK1/PPP2R2B/ITGA4/CHUK/JAK2/F2R/STK11/PPP2R3A	0.679873274159225
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/987	59/9376	1.2880669036457	IRS2/PDE3B/ABHD5/AKT3/GNAI3/PIK3CA/GNAS/PNPLA2	0.761325611408751
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/987	85/9376	1.22934620656773	UPP1/CMPK1/ADSL/NT5C3B/NT5C3A/NME2/RRM2B/CMPK2/ADA/CTPS1/ADK	0.728549243151247
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/987	94/9376	1.21270128694303	JUND/TNFAIP3/NFKB1/TRAF4/CASP3/SRSF1/TBK1/CASP8/MAPK8/TRAF3/IKBKB/CHUK	0.7108899584006
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/987	51/9376	1.30385203726881	PLCG2/SEC61G/SLC12A2/ATP6V1A/ATP6V1G1/GNAS/SEC61B	0.746297415635522
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/987	148/9376	1.15534379364167	BRAF/CTNNB1/NFKB2/AKT3/SOS2/TCF7/ESR2/SOS1/PIK3CA/MAP2K1/FRAT1/RPS6KB1/AXIN1/LEF1/FRAT2/FGF9/CSNK1A1/GADD45A	0.653371352966352
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/987	238/9376	1.11758746051612	RALGAPA1/PLCG2/NFKB1/ARF6/RASA3/AKT3/SOS2/ABL1/GNG2/RASA2/RASGRP1/FLT3LG/REL/CALM2/RAB5A/SOS1/PIK3CA/MAP2K1/TBK1/RALGDS/ETS1/MAPK8/SYNGAP1/FGF9/IKBKB/NF1/CHUK/CALM3	0.630250255209739
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/987	122/9376	1.1679705017689	CTNNB1/PLCG2/MED14/FOXO1/AKT3/ATP1B3/ATP1A1/ATP2A2/RHEB/HIF1A/PIK3CA/MAP2K1/MED13/ITGAV/PDPK1	0.640526798623797
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/987	78/9376	1.21788377107526	IFNGR1/EEF1A1/TGFB1/NFKB1/HLA-DQA2/HLA-DPB1/MARCKSL1/HLA-DQB1/ITGA4/JAK2	0.662775629811305
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/987	204/9376	1.11758746051612	PPP1CB/BRAF/CTNNB1/CD44/PLCG2/TGFB1/DDX5/PDCD4/AKT3/RPS6/SOS2/ITGA5/CAMK2D/EIF4B/HIF1A/PPP1CC/SOS1/CASP3/PIK3CA/MAP2K1/RPS6KB1/EZR/ITGAV/PDPK1	0.582415855053321
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	29/987	250/9376	1.1019412360689	PLEKHM1/GALC/IDS/AP1S2/AP3M2/AP2B1/CTBS/GPR155/MCOLN2/OSBP/NCOA7/CLN8/SLC15A4/AP1G1/OSBPL7/GGA2/LAPTM4B/AP5Z1/BLOC1S2/VPS13A/ATP6V1A/ATP6V1G1/HGSNAT/BLOC1S6/LAMTOR3/M6PR/BLOC1S4/ARL8B/BLOC1S1	0.560362139383445
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/987	71/9376	1.20416113703498	SLC7A5/LDHA/SLC16A3/AKT3/TIGAR/HIF1A/GLS/PIK3CA/MAP2K1	0.592288334106645
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/987	170/9376	1.11758746051612	TUBA4A/RAP2C/ARPC1B/LLGL1/TUBA1A/PRKCE/PPP2R2D/WHAMM/ARHGAP17/PPP2CA/TUBA8/MAP2K7/MAPK8/EZR/ARHGEF2/PRKAA1/HSPA4/PPP2R2B/MAP3K5/STK11	0.530687800265678
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/987	89/9376	1.17409469166581	TUBA4A/TUBB2A/TUBB4B/SOS2/TUBA1A/GNAI3/SOS1/MAP2K1/CSNK1D/TUBA8/GNAS	0.566020195609565
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/987	45/9376	1.26659912191827	TAP1/ABCB1/TAP2/ABCG1/ABCD2/ABCD3	0.614879471986665
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/987	54/9376	1.2314158129761	HLA-C/HLA-B/HLA-DQA2/HLA-A/HLA-DPB1/CD28/HLA-DQB1	0.584957723479788
NA	NA	hsa04517	IgSF CAM signaling	34/987	299/9376	1.08020995347545	TUBA4A/TUBB2A/CTNNB1/PLCG2/CD2/TUBB4B/FOXO1/ARPC1B/ARF6/AKT3/TUBA1A/ABL1/NCK2/ITGA5/CD48/DYNLL2/FYN/PIK3CA/MAP2K1/ROBO3/MTSS1/TUBA8/MAPK8/PRKCQ/CD226/ICAM2/EZR/CD28/ICAM1/PDPK1/ITGA4/ICAM3/SLAMF1/NCK1	0.483483667933982
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/987	20/9376	1.42492401215805	CYP51A1/SC5D/DHCR7	0.652484624317171
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/987	55/9376	1.20902643455835	CERK/GALC/DEGS1/UGCG/SGMS1/SPTLC1/SGPP1	0.533261734324296
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/987	29/9376	1.31027495370856	CSNK1E/LATS2/MOB1A/SAV1	0.573982583161808
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/987	65/9376	1.16916842023225	AGPAT4/AGPAT5/PLPP5/PNPLA2/LPIN2/ALDH7A1/DGKA/ALDH9A1	0.469425768607368
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/987	21/9376	1.35707048776958	DPYD/PANK2/CSAD	0.561863506974157
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/987	93/9376	1.12359599525008	SOS2/MAP2K3/CAMK2D/CALM2/SOS1/MAP2K4/MAP2K1/MAP2K7/MAPK8/GNAS/CALM3	0.410857117964656
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/987	160/9376	1.06869300911854	HLA-C/CD2/HLA-B/HLA-DQA2/SELL/CD8A/CD58/HLA-A/ICOS/CD226/HLA-DPB1/ICAM2/CD28/ICAM1/HLA-DQB1/ITGAV/ITGA4/ICAM3	0.300600997103308
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	25/987	226/9376	1.05082891752069	PPP1CB/BRAF/NFATC1/PDE3B/NFKB1/ATP2B1/AKT3/PDE4B/PDE4D/ATP1B3/ATP1A1/ORAI1/ATP2A2/GNAI3/GIPR/CAMK2D/CALM2/PPP1CC/PTGER2/PIK3CA/MAP2K1/MAPK8/GNAS/CALM3/F2R	0.265303910081547
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/987	78/9376	1.09609539396773	NFKB1/ITGA5/IL23A/GNAI3/CALM2/CASP3/MAPK8/CASP1/CALM3	0.292310367792061
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/987	23/9376	1.23906435839831	ATP1B3/ATP1A1/GLS	0.393724464566832
Organismal Systems	Immune system	hsa04611	Platelet activation	14/987	126/9376	1.05549926826523	PPP1CB/PLCG2/AKT3/STIM1/ORAI1/GNAI3/RASGRP1/PPP1CC/FYN/PIK3CA/PIK3R5/TBXAS1/GNAS/F2R	0.215124949157111
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/987	98/9376	1.06626966896181	PLCG2/PIP4K2A/PIK3C2A/CALM2/PIK3CA/PIK3C2B/SYNJ2/ITPKA/CDS2/DGKA/CALM3	0.226198526878003
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/987	98/9376	1.06626966896181	PLCG2/ARPC1B/ARF6/AKT3/PRKCE/PIK3CA/MAP2K1/RPS6KB1/AMPH/MARCKSL1/DNM2	0.226198526878003
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/987	193/9376	1.03362363576232	CXCR4/BRAF/PLCG2/NFKB1/AKT3/SOS2/CCL3L1/GNG2/GNAI3/SOS1/PIK3CA/MAP2K1/ELMO1/PIK3R5/STAT5B/CCR7/IKBKB/CHUK/JAK2/ITK/GRK2	0.161890048094251
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/987	52/9376	1.09609539396773	VAPB/VDAC3/MYLIP/VAPA/CIDEB/VDAC1	0.238337417007724
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/987	15/9376	1.26659912191827	ST3GAL1/ST6GALNAC6	0.354431521367901
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/987	53/9376	1.07541434879853	ATP2B1/AP2B1/ATP1B3/ATP1A1/GNAS/DNM2	0.188844001928172
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/987	110/9376	1.03630837247859	BRAF/PDE3B/AKT3/GNAI3/ANAPC16/ANAPC1/PIK3CA/MAP2K1/CPEB2/MAPK8/CDC25B/RPS6KA3	0.131385093389352
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/987	44/9376	1.07948788799853	POLD4/TDG/MBD4/POLB/APTX	0.181271299612719
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/987	63/9376	1.05549926826523	EZH2/KMT2E/ALDH7A1/EZH1/CAMKMT/KMT5A/ALDH9A1	0.15160092380693
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/987	54/9376	1.05549926826523	FANCA/POLH/MLH1/PMS2/CENPS-CORT/RPA3	0.140287412522556
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/987	36/9376	1.05549926826523	GALNT11/GALNT3/ST3GAL1/C1GALT1	0.114433764952547
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/987	104/9376	1.00475411113709	GPCPD1/AGPAT4/LPCAT1/ETNK1/AGPAT5/PLPP5/LPIN2/SGMS1/CDS2/DGKA/CHKB	0.0167220071788625
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/987	95/9376	0.999946675198635	TGFB1/HLA-DQA2/CCL3L1/IL23A/HLA-DPB1/ATP6V1A/ATP6V1G1/CD28/ICAM1/HLA-DQB1	-0.000179177214204322
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/987	27/9376	1.05549926826523	ELOVL5/HACD2/HACD4	0.09905483449887
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/987	76/9376	0.999946675198635	ATP1B3/ATP1A1/GNAI3/CAMK2D/CALM2/EZR/GNAS/CALM3	-0.00016009718124764
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/987	37/9376	1.02697226101481	ADSL/GFPT1/GFPT2/GLS	0.0563841639786093
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/987	37/9376	1.02697226101481	UAP1/GFPT1/GFPT2/NANS	0.0563841639786093
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/987	87/9376	0.982706215281417	ATP1B3/ATP1A1/ATP2A2/UQCRFS1/UQCRB/UQCRC2/UQCR11/COX7C/COX7B	-0.0555845777107824
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/987	28/9376	1.01780286582718	ELOVL5/HACD2/HACD4	0.0323592688226245
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/987	28/9376	1.01780286582718	SLC12A7/ATP6V1A/ATP6V1G1	0.0323592688226245
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/987	38/9376	0.999946675198635	ATP1B3/ATP1A1/PIK3CA/PDPK1	-0.000112975228195859
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/987	18/9376	1.05549926826523	LMBRD1/MTRR	0.0808390324049601
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/987	48/9376	0.989530563998649	HIBCH/HMGCS1/PCCB/ALDH7A1/ALDH9A1	-0.0249424295233665
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/987	98/9376	0.969336062692554	PRKD3/ATP2B1/ATP1B3/ATP1A1/ORAI1/PRKCE/CAMK2D/CALM2/GNAS/CALM3	-0.104665340205953
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/987	39/9376	0.974307016860208	MAT2A/MTHFS/ALDH7A1/MTHFD2	-0.0551483182748116
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/987	89/9376	0.960622929544756	SLC38A1/SLC38A2/GABARAP/GNG2/GNAI3/GLS/GABARAPL2/GABARAPL1/NSF	-0.128023530805825
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/987	99/9376	0.959544789332023	BRAF/AKT3/SOS2/ESR2/SOS1/PIK3CA/MAP2K1/RPS6KB1/MAPK8/GNAS	-0.138796144826855
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/987	19/9376	0.999946675198635	IDS/HGSNAT	-7.98044023336191e-05
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/987	139/9376	0.956783509362723	FKBP5/RARA/AKT3/SOS2/FKBP4/GNAI3/CALM2/ESR2/SOS1/HSPA8/PIK3CA/MAP2K1/GNAS/CALM3	-0.176068045434699
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/987	130/9376	0.949949341438703	TGFB1/NFKB1/AKT3/SOS2/GNG2/GNAI3/SOS1/PIK3CA/MAP2K4/MAP2K1/MAP2K7/MAPK8/GNAS	-0.197103186393722
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/987	30/9376	0.949949341438703	NFKB1/IKBKB/CHUK	-0.0941773904817301
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/987	20/9376	0.949949341438703	UAP1/NANS	-0.0768544121155658
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/987	41/9376	0.926779845306052	POLD4/UIMC1/RAD52/RPA3	-0.161158986173334
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/987	93/9376	0.919305814295519	CTNNB1/SMAD3/PTPRJ/TCF7/SMURF2/FYN/LEF1/YES1/CCM2	-0.268243161988912
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/987	83/9376	0.915613823073449	ACSL3/MPV17L/NUDT19/SOD1/ABCD2/ABCD3/PEX2/PEX14	-0.264863129877332
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/987	203/9376	0.935910681220397	PPP1CB/BRAF/CTNNB1/BIRC2/AKT3/SOS2/ITGA5/PPP1CC/SOS1/BIRC3/FYN/CCND2/PIK3CA/MAP2K1/MAPK8/RAPGEF1/CAPN2/ITGAV/PDPK1/ITGA4	-0.316640960992095
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/987	63/9376	0.904713658513051	CTNNB1/TCF7/AXIN1/LEF1/PTCH2/GADD45A	-0.260282664026676
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/987	21/9376	0.904713658513051	CSGALNACT2/CHST11	-0.14993655266504
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	18/987	184/9376	0.929298268798731	CXCR4/PLCG2/EPHA4/PPP3R1/ABL1/NCK2/ABLIM1/SSH2/GNAI3/CAMK2D/FYN/RYK/PIK3CA/ROBO3/PPP3CA/PPP3CC/PDPK1/NCK1	-0.332217930898353
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/987	32/9376	0.890577507598784	LDHA/HIBCH/PCCB	-0.212669051646313
Human Diseases	Immune disease	hsa05310	Asthma	3/987	32/9376	0.890577507598784	HLA-DQA2/HLA-DPB1/HLA-DQB1	-0.212669051646313
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/987	323/9376	0.941126282539892	IRS2/CD44/PLCG2/EZH2/PIM1/SIRT1/NFKB1/BCL2L11/PDCD4/SOS2/VIM/HDAC4/ABL1/ABCB1/ITGA5/MCL1/PRKCE/DDIT4/CCNG1/SOS1/CASP3/GLS/CCND2/PIK3CA/MAP2K1/FOXP1/SOCS1/RPS6KA5/EZR/IKBKB/CDC25B/CCNE2	-0.369330843270407
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/987	43/9376	0.883673805989491	ACSL3/CPT1A/ALDH7A1/ALDH9A1	-0.262234743686648
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/987	116/9376	0.900814030674632	CXCR4/CTNNB1/PLCG2/RHOH/GNAI3/SIPA1/PIK3CA/EZR/ICAM1/ITGA4/ITK	-0.368691275275295
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/987	116/9376	0.900814030674632	SLC38A1/SLC38A2/PPP3R1/GNG2/GNAI3/GLS/PPP3CA/PPP3CC/SLC1A2/GNAS/GRK2	-0.368691275275295
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/987	86/9376	0.883673805989491	CTNNB1/LMNA/ITGA5/ATP2A2/TCF7/LEF1/ITGAV/ITGA4	-0.371713218164482
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/987	97/9376	0.88139629618024	PER2/PER1/GNG2/GNAI3/CAMK2D/CALM2/RPS6KA5/GNAS/CALM3	-0.402738036817512
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/987	23/9376	0.826042905598872	B4GALT1/B3GALNT2	-0.286496758904445
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/987	23/9376	0.826042905598872	ATP6AP2/MAS1	-0.286496758904445
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	14/987	149/9376	0.892569851016231	NDUFA13/NDUFB1/NDUFA7/GNG2/GNAI3/NDUFV2/NDUFB8/MT-ND4L/NDUFA1/NDUFC1/NDUFA6/NDUFS5/MAPK8/NDUFC2	-0.453396506248613
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/987	67/9376	0.850700902780928	ALDOA/LDHA/PGK1/GALM/ALDH7A1/ALDH9A1	-0.420660937304023
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/987	78/9376	0.852518639752682	PLCG2/PIP4K2A/PIK3C2A/PIK3CA/PIK3C2B/SYNJ2/ITPKA	-0.448620156246427
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/987	57/9376	0.833288895998862	ACSL3/ELOVL5/HACD2/CPT1A/HACD4	-0.433018465660502
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/987	232/9376	0.900814030674632	PPP1CB/CXCR4/BRAF/RGCC/ARPC1B/AKT3/SOS2/PIP4K2A/FGD3/ITGA5/SSH2/PPP1CC/SOS1/PIK3CA/MAP2K1/EZR/FGF9/ITGAV/ITGA4/F2R/ARHGEF7/ITGAE	-0.524705048767034
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/987	24/9376	0.791624451198919	NDST2/HS3ST3B1	-0.350581702526648
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/987	12/9376	0.791624451198919	SLAMF1	-0.247739806753307
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/987	79/9376	0.841727264565939	AP2B1/ATP6V1A/NAPA/ATP6V1G1/SLC1A2/NSF/DNM2	-0.484548614224228
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/987	47/9376	0.808467524628684	LDHA/ACYP2/ALDH7A1/ALDH9A1	-0.451505371372928
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/987	254/9376	0.89758992891846	PHKG1/CXCR4/PLCG2/NFATC1/ATP2B1/STIM1/PPP3R1/ORAI1/ATP2A2/MCOLN2/CAMK2D/CALM2/VDAC3/STIM2/PPP3CA/PPP3CC/P2RX4/FGF9/GNAS/ITPKA/ORAI2/CALM3/F2R/VDAC1	-0.567549322095976
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/987	101/9376	0.846489512173102	CTNNB1/GNAI3/CAMK2D/CALM2/TCF7/MAP2K1/LEF1/GNAS/CALM3	-0.532023599166936
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/987	91/9376	0.835120300165893	PDE3B/PDE4B/PDE4D/GNG2/GNAI3/PDE7A/GNAS/GRK2	-0.542108288707823
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/987	59/9376	0.805041814778562	ODC1/LAP3/RRM2B/GPX4/PRDX6	-0.515250650749541
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/987	154/9376	0.863590310398821	PPP1CB/NFATC1/PPP3R1/GNAI3/CAMK2D/CALM2/PPP1CC/MAP2K1/PPP3CA/PIK3R5/PPP3CC/GNAS/PRKAA1/CALM3	-0.585439659440036
NA	NA	hsa03272	Virion - Hepatitis viruses	4/987	48/9376	0.791624451198919	CHMP4B/CHMP1B/IST1/PDCD6IP	-0.496434806965071
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/987	48/9376	0.791624451198919	AKT3/ATP1B3/ATP1A1/PIK3CA	-0.496434806965071
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/987	217/9376	0.875529346948113	NFKB1/AKT3/SOS2/PTGES3/KPNA4/GNAI3/ESR2/SOS1/PIK3CA/MAP2K1/RPS6KB1/STAT5B/KPNA3/FGF9/ARNT/KPNA2/GNAS/JAK2/STAT5A/RPS6KA3	-0.636299999492834
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/987	60/9376	0.791624451198919	BRAF/GNAI3/PPP2CA/MAP2K1/GNAS	-0.555388341851514
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/987	38/9376	0.749960006398976	UAP1/GFPT1/GFPT2	-0.529740845010617
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/987	38/9376	0.749960006398976	SIRT1/NMRK1/SIRT2	-0.529740845010617
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/987	61/9376	0.778647001179265	ATP2B1/MT2A/ATP1B3/ATP1A1/ATP7A	-0.594905542734655
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/987	73/9376	0.78078028063455	BRAF/AKT3/PIK3CA/MAP2K1/FGF9/GADD45A	-0.644939021514696
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/987	28/9376	0.678535243884788	B4GALT1/B3GNT2	-0.58430842321178
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/987	28/9376	0.678535243884788	GCH1/PTS	-0.58430842321178
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/987	41/9376	0.695084883979539	BRAF/MAP2K1/RPS6KA5	-0.671124107456214
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/987	29/9376	0.655137476854278	CALM2/CALM3	-0.637966679246729
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/987	16/9376	0.593718338399189	MIF	-0.557876932483888
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/987	16/9376	0.593718338399189	ST3GAL1	-0.557876932483888
NA	NA	hsa04518	Integrin signaling	13/987	154/9376	0.801905288227477	CTNNB1/TGFB1/AKT3/NCK2/ITGA5/CCND2/PIK3CA/ICAM2/ICAM1/ITGAV/ITGA4/ICAM3/ITGAE	-0.850177879123154
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/987	30/9376	0.633299560959135	SDHA/CS	-0.689998721896508
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/987	78/9376	0.730730262645156	CTNNB1/ARPC1B/ITGA5/PIK3CA/ELMO1/DNM2	-0.81908541826567
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/987	17/9376	0.558793730258061	CSAD	-0.624511628942933
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/987	17/9376	0.558793730258061	CA5B	-0.624511628942933
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/987	17/9376	0.558793730258061	TFRC	-0.624511628942933
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/987	31/9376	0.612870542863679	ALDH7A1/ALDH9A1	-0.740519552389904
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/987	31/9376	0.612870542863679	CS/PCCB	-0.740519552389904
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/987	212/9376	0.806560761598899	BRAF/CTNNB1/PRKD3/AKT3/GNAI3/MAP2K3/CALM2/SIPA1/PIK3CA/MAP2K1/RALGDS/ID1/RAPGEF1/SIPA1L1/FGF9/GNAS/CALM3/F2R	-0.977145150917293
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/987	32/9376	0.593718338399189	B4GALT1/GALM	-0.789632312131219
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/987	18/9376	0.527749634132613	ACSL3	-0.687869657076689
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/987	115/9376	0.743438615038985	AKT3/GNG2/GNAI3/CAMK2D/FYN/PIK3CA/MAP2K1/PIK3R5/JAK2	-0.949511844728219
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/987	115/9376	0.743438615038985	JUND/BRAF/PDE4B/PDE4D/GNAI3/GATA3/MAP2K1/GNAS/MEF2D	-0.949511844728219
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/987	93/9376	0.715015633340959	ATP2B1/ATP1B3/ATP1A1/CALM2/SLC12A2/GNAS/CALM3	-0.947343441942481
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/987	35/9376	0.54282819510783	ALDOA/TIGAR	-0.929406898775552
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/987	49/9376	0.581601637615533	NFKB1/GNAI3/GNAS	-1.00717780097512
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/987	155/9376	0.735444651436415	BRAF/CTNNB1/ORAI1/GNAI3/CAMK2D/TCF7/MAP2K1/AXIN1/LEF1/ARNT/GNAS/CCNE2	-1.13915416291079
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	11/987	144/9376	0.725655746932343	SKIL/CTNNB1/SMAD3/AKT3/TCF7/PIK3CA/MAP2K1/PCGF5/ID1/AXIN1/JAK2	-1.13793729824417
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/987	36/9376	0.527749634132613	POLD4/RPA3	-0.973731529362947
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/987	75/9376	0.633299560959135	ALDOA/PGK1/MAT2A/CS/PSPH	-1.09361978045233
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/987	99/9376	0.671681352532416	TGFB1/LMNA/ITGA5/ATP2A2/PRKAA1/ITGAV/ITGA4	-1.12641515866186
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/987	50/9376	0.569969604863222	TGFB1/KLRK1/ICAM1	-1.04574444705566
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/987	134/9376	0.708917418984107	PPP1CB/BRAF/PRKCE/RAMP1/CALM2/PPP1CC/MAP2K1/PRKCQ/GNAS/CALM3	-1.16405835296209
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/987	63/9376	0.6031424390087	PTGES3/TBXAS1/LTA4H/GPX4	-1.08404983969389
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/987	37/9376	0.513486130507407	APOL1/ICAM1	-1.01703293543955
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/987	100/9376	0.664964539007092	CXCR4/IL18RAP/CCL3L1/IL18R1/TNFRSF10B/CCR7/IL24	-1.15531263669822
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/987	76/9376	0.624966671999147	ACSL3/HMGCS1/CPT1A/UBC/PDPK1	-1.12596347571515
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/987	65/9376	0.584584210116125	AKT3/ESR2/PIK3CA/MAP2K1	-1.15273805944485
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/987	23/9376	0.413021452799436	GLS	-0.966717982375722
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/987	194/9376	0.734496913483533	TUBA4A/TUBB2A/TUBB4B/BICDL1/TUBA1A/DYNLT3/DCTN6/DYNLL2/DYNC1H1/MYO15A/TUBA8/KIF1B/KIFAP3/CAPZA1/KIF21A	-1.28171336309443
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/987	103/9376	0.645596639812711	TGFB1/SERPINB9/NFKB1/RAB5A/CASP3/PIK3CA/GNAS	-1.24049617842586
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/987	128/9376	0.667933130699088	PDE3B/PDE4B/PDE4D/ADSL/PDE7A/NME2/RRM2B/ADA/ADK	-1.29746526297634
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/987	54/9376	0.527749634132613	AMD1/LDHA/MAT2A	-1.19372352034914
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/987	105/9376	0.633299560959135	TGFB1/LMNA/ITGA5/ATP2A2/GNAS/ITGAV/ITGA4	-1.29608029024147
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/987	41/9376	0.463389922653026	ALDH7A1/PSPH	-1.1810892287391
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/987	82/9376	0.579237403316282	UPP1/CMPK1/DPYD/NME2/RRM2B	-1.31259829591544
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/987	26/9376	0.365365131322578	LMBRD1	-1.11146019982301
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/987	42/9376	0.452356829256525	ALDH7A1/ALDH9A1	-1.220049750727
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/987	27/9376	0.351833089421742	HMGCS1	-1.15684527133129
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/987	89/9376	0.533679405302642	CD44/CD47/ITGA5/ITGAV/ITGA4	-1.5161109836366
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/987	102/9376	0.558793730258061	ATP2B1/ATP1B3/ATP1A1/ATP2A2/SLC12A2/GNAS	-1.53672916185393
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/987	30/9376	0.316649780479568	PIGX	-1.28582005331129
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/987	103/9376	0.553368548410895	COL8A1/SLC3A2/ATP1B3/SLC38A2/ATP1A1/COL24A1	-1.56331646677472
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/987	90/9376	0.527749634132613	HMGCR/ATP1B3/ATP1A1/ABCB1/GNAS	-1.54407480107269
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/987	116/9376	0.573245292247493	ALDOA/PGK1/HIBCH/SDHA/CS/PCCB/PSPH	-1.58632050985831
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/987	31/9376	0.30643527143184	ALDOA	-1.32668344628672
NA	NA	hsa04981	Folate transport and metabolism	1/987	31/9376	0.30643527143184	MTHFS	-1.32668344628672
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/987	154/9376	0.616850221713444	GCH1/CMPK1/ADSL/PTS/NME2/MAT2A/PANK2/CMPK2/CTPS1/MTHFD2	-1.64439253817251
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/987	33/9376	0.287863436799607	CS	-1.40561439825975
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/987	51/9376	0.372529153505374	PAFAH1B1/LPCAT1	-1.54114441796979
NA	NA	hsa04081	Hormone signaling	15/987	219/9376	0.650650233862125	IRS2/ADIPOR2/GNG2/GNAI3/GIPR/RAMP1/ESR2/PIK3CA/ADRA2B/STAT5B/GNAS/ITGAV/JAK2/STAT5A/STK11	-1.79429986529506
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/987	37/9376	0.256743065253704	MIF	-1.55374148514862
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/987	86/9376	0.441836902994746	ATP1B3/ATP1A1/CAMK2D/GNAS	-1.78357594188746
Human Diseases	Substance dependence	hsa05034	Alcoholism	12/987	191/9376	0.596826811375101	PPP1CB/BRAF/SOS2/HDAC4/GNG2/GNAI3/CALM2/PPP1CC/SOS1/MAP2K1/GNAS/CALM3	-1.93089147035161
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/987	298/9376	0.669427388262173	IFNGR1/CXCR4/IL7R/TNFRSF25/TGFB1/RELT/IL18RAP/IL4R/TNFSF9/CCL3L1/IL23A/IL18R1/IL27RA/IL12RB2/RELL1/IL21R/TNFRSF9/TNFRSF10B/CCR7/IL24/CLCF1	-1.98915684768579
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/987	115/9376	0.495625743359323	BRAF/GNG2/GNAI3/CASP3/MAP2K1/GNAS	-1.8666461865611
NA	NA	hsa04382	Cornified envelope formation	14/987	217/9376	0.612870542863679	PPP2R5C/ABHD5/PPP2R5A/PPP2R3C/S100A10/PPP2R2D/FURIN/PPP2CA/UGCG/BLMH/S100A4/SPTLC1/PPP2R2B/PPP2R3A	-1.97902451172018
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/987	88/9376	0.431795155199411	CD55/F2RL2/F2R/PLAT	-1.83685249483699
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/987	75/9376	0.379979736575481	ATP1B3/ATP1A1/GNAS	-1.84910175219822
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/987	65/9376	0.292292105058063	ORAI1/GNAS	-1.96381997347096
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/987	99/9376	0.383817915732809	HLA-DQA2/HLA-DPB1/ICAM1/HLA-DQB1	-2.11403417249686
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/987	52/9376	0.182682565661289	GNAS	-2.02712448674777
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/987	195/9376	0.487153508430104	PLCG2/NFKB1/AKT3/HDAC4/VDAC3/PIK3CA/MAP2K1/CASP1/CLCN3/VDAC1	-2.48226885448278
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/987	233/9376	0.489244296019933	LMNA/VIM/ATP1B3/ATP1A1/ITGA5/COL24A1/TMEM43/CAPZA1/ITGAV/DAAM1/ITGA4/FMNL1	-2.70792070785563
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/987	66/9376	0.143931718399804	HSD17B11	-2.39383741619131
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/987	183/9376	0.363368600550324	SBDS/NXT1/NOP58/SNU13/UTP15/GTPBP4/GNL3	-2.98314310089767
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/987	143/9376	0.26572009550733	HLA-DQA2/HLA-DPB1/CD28/HLA-DQB1	-3.03492079255962
NA	NA	hsa04082	Neuroactive ligand signaling	7/987	199/9376	0.334153034676931	OGFRL1/GNG2/GNAI3/ADRA2B/P2RX4/SLC1A2/GNAS	-3.25641475903187
NA	NA	hsa04519	Cadherin signaling	21/987	404/9376	0.493785548767643	PPP1CB/CTNNB1/NFKB1/ARPC1B/LATS2/VIM/YWHAQ/MAP2K3/MOB1A/TCF7/PPP1CC/RYK/MAP2K1/MAPK8/AXIN1/LEF1/CSNK1A1/IKBKB/DAAM1/CHUK/SAV1	-3.56754702598802
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/987	370/9376	0.359440291355185	P2RY8/S1PR1/OGFRL1/S1PR4/PGRMC2/GPR35/GIPR/PTGER2/MAS1/ADRA2B/P2RX4/F2RL2/P2RY10/F2R	-4.31204839139931
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/987	449/9376	0.105785004614555	CAMK2D/CALM2/NCALD/CALM3/GRK2	-6.66041773981826