ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003725 double-stranded RNA binding 10/308 75/18639 0.133333333333333 8.06883116883117 4.20986066918283e-07 0.000263116291823927 GO:0004896 cytokine receptor activity 10/308 96/18639 0.104166666666667 6.30377435064935 4.21998355597824e-06 0.00103406666601778 GO:0019955 cytokine binding 12/308 144/18639 0.0833333333333333 5.04301948051948 4.96351999688534e-06 0.00103406666601778 GO:0140375 immune receptor activity 12/308 156/18639 0.0769230769230769 4.65509490509491 1.12883192344478e-05 0.00176379988038247 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/308 16/18639 0.25 15.1290584415584 0.000113753100996709 0.0138244371968135 GO:0038187 pattern recognition receptor activity 6/308 48/18639 0.125 7.56452922077922 0.00013271459708941 0.0138244371968135 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/308 40/18639 0.125 7.56452922077922 0.0004884630850297 0.0436127754490804 GO:0019957 C-C chemokine binding 4/308 24/18639 0.166666666666667 10.086038961039 0.000598397685208493 0.0464026940160764 GO:0003953 NAD+ nucleosidase activity 3/308 11/18639 0.272727272727273 16.504427390791 0.0006681987938315 0.0464026940160764 GO:0019787 ubiquitin-like protein transferase activity 18/308 479/18639 0.0375782881002088 2.27409646720711 0.0010851447432395 0.0642126302149988 GO:0035325 Toll-like receptor binding 3/308 13/18639 0.230769230769231 13.9652847152847 0.00113014229178398 0.0642126302149988 GO:0004842 ubiquitin-protein transferase activity 17/308 449/18639 0.0378619153674833 2.29126052121598 0.00136775847249021 0.0674195811823822 GO:0070566 adenylyltransferase activity 4/308 30/18639 0.133333333333333 8.06883116883117 0.00142766312468463 0.0674195811823822 GO:0016755 aminoacyltransferase activity 18/308 496/18639 0.0362903225806452 2.19615364474235 0.00159907913427446 0.0674195811823822 GO:0005164 tumor necrosis factor receptor binding 4/308 31/18639 0.129032258064516 7.80854629241726 0.00161806994837717 0.0674195811823822 GO:0050700 CARD domain binding 3/308 15/18639 0.2 12.1032467532468 0.0017544511428535 0.0685332477677149 GO:0019956 chemokine binding 4/308 33/18639 0.121212121212121 7.33530106257379 0.00205051014680428 0.0711982689862596 GO:0071889 14-3-3 protein binding 4/308 33/18639 0.121212121212121 7.33530106257379 0.00205051014680428 0.0711982689862596 GO:0005126 cytokine receptor binding 12/308 275/18639 0.0436363636363636 2.64070838252656 0.00216644270275158 0.0712645625905125 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/308 36/18639 0.111111111111111 6.72402597402597 0.00283947124739307 0.0887334764810336 GO:0061659 ubiquitin-like protein ligase activity 14/308 372/18639 0.0376344086021505 2.2774926686217 0.0037333006138649 0.108360695561078 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 4/308 39/18639 0.102564102564103 6.20679320679321 0.00381429648374993 0.108360695561078 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/308 21/18639 0.142857142857143 8.64517625231911 0.00476623625163165 0.129517289446512 GO:0033691 sialic acid binding 3/308 22/18639 0.136363636363636 8.25221369539551 0.00545204212603709 0.133492878623352 GO:0005125 cytokine activity 10/308 234/18639 0.0427350427350427 2.58616383616384 0.0057085542171771 0.133492878623352 GO:0061630 ubiquitin protein ligase activity 13/308 353/18639 0.0368271954674221 2.2286431698613 0.00610393637347068 0.133492878623352 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/308 23/18639 0.130434782608696 7.89342179559571 0.00619406956812355 0.133492878623352 GO:0016493 C-C chemokine receptor activity 3/308 23/18639 0.130434782608696 7.89342179559571 0.00619406956812355 0.133492878623352 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/308 23/18639 0.130434782608696 7.89342179559571 0.00619406956812355 0.133492878623352 GO:0016779 nucleotidyltransferase activity 7/308 136/18639 0.0514705882352941 3.11480614973262 0.00749678093218781 0.152337014771876 GO:0044389 ubiquitin-like protein ligase binding 12/308 322/18639 0.0372670807453416 2.2552633701702 0.00755591593268505 0.152337014771876 GO:0016763 pentosyltransferase activity 4/308 49/18639 0.0816326530612245 4.94010071561092 0.00864026973521788 0.161181827017776 GO:0001637 G protein-coupled chemoattractant receptor activity 3/308 26/18639 0.115384615384615 6.98264235764236 0.008768291389767 0.161181827017776 GO:0004950 chemokine receptor activity 3/308 26/18639 0.115384615384615 6.98264235764236 0.008768291389767 0.161181827017776 GO:0032813 tumor necrosis factor receptor superfamily binding 4/308 50/18639 0.08 4.8412987012987 0.00927203239914666 0.165572007127619 GO:0005381 iron ion transmembrane transporter activity 2/308 10/18639 0.2 12.1032467532468 0.0112207398797107 0.194804511800533 GO:0140313 molecular sequestering activity 4/308 55/18639 0.0727272727272727 4.40118063754427 0.0128805179772668 0.197176584446309 GO:0048019 receptor antagonist activity 3/308 30/18639 0.1 6.05162337662338 0.0130449765086013 0.197176584446309 GO:0061134 peptidase regulator activity 9/308 226/18639 0.0398230088495575 2.40993851281462 0.0131204274274349 0.197176584446309 GO:0019208 phosphatase regulator activity 6/308 117/18639 0.0512820512820513 3.1033966033966 0.0131545553754902 0.197176584446309 GO:0047676 arachidonate-CoA ligase activity 2/308 11/18639 0.181818181818182 11.0029515938607 0.0135657490099061 0.197176584446309 GO:0050786 RAGE receptor binding 2/308 11/18639 0.181818181818182 11.0029515938607 0.0135657490099061 0.197176584446309 GO:0140537 transcription regulator activator activity 2/308 11/18639 0.181818181818182 11.0029515938607 0.0135657490099061 0.197176584446309 GO:0016504 peptidase activator activity 4/308 57/18639 0.0701754385964912 4.24675324675325 0.0145422615537062 0.204897759834219 GO:0032182 ubiquitin-like protein binding 6/308 120/18639 0.05 3.02581168831169 0.0147526387080638 0.204897759834219 GO:0003727 single-stranded RNA binding 5/308 89/18639 0.0561797752808989 3.39978841383336 0.0160332916692653 0.209672991408762 GO:0035251 UDP-glucosyltransferase activity 2/308 12/18639 0.166666666666667 10.086038961039 0.0161028857401929 0.209672991408762 GO:0097677 STAT family protein binding 2/308 12/18639 0.166666666666667 10.086038961039 0.0161028857401929 0.209672991408762 GO:0015026 coreceptor activity 4/308 61/18639 0.0655737704918033 3.96827762401533 0.0182576493392746 0.23287818034789 GO:0004467 long-chain fatty acid-CoA ligase activity 2/308 15/18639 0.133333333333333 8.06883116883117 0.0247984634592494 0.308386891805561 GO:0043130 ubiquitin binding 5/308 100/18639 0.05 3.02581168831169 0.0251643703713338 0.308386891805561 GO:0140767 enzyme-substrate adaptor activity 6/308 139/18639 0.0431654676258993 2.61221152947772 0.0280806846431204 0.332178571157352 GO:0042379 chemokine receptor binding 4/308 72/18639 0.0555555555555556 3.36201298701299 0.0313080378177269 0.332178571157352 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/308 17/18639 0.117647058823529 7.11955691367456 0.0314333999668217 0.332178571157352 GO:0008429 phosphatidylethanolamine binding 2/308 17/18639 0.117647058823529 7.11955691367456 0.0314333999668217 0.332178571157352 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/308 17/18639 0.117647058823529 7.11955691367456 0.0314333999668217 0.332178571157352 GO:0036041 long-chain fatty acid binding 2/308 17/18639 0.117647058823529 7.11955691367456 0.0314333999668217 0.332178571157352 GO:0019888 protein phosphatase regulator activity 5/308 107/18639 0.0467289719626168 2.8278613909455 0.0324207358992426 0.332178571157352 GO:0061135 endopeptidase regulator activity 7/308 184/18639 0.0380434782608696 2.30224802371542 0.0335508735213809 0.332178571157352 GO:0016757 glycosyltransferase activity 9/308 267/18639 0.0337078651685393 2.03987304830001 0.0339443365937582 0.332178571157352 GO:0017128 phospholipid scramblase activity 2/308 18/18639 0.111111111111111 6.72402597402597 0.0349834283667342 0.332178571157352 GO:0019003 GDP binding 4/308 75/18639 0.0533333333333333 3.22753246753247 0.0356141828904123 0.332178571157352 GO:0030547 signaling receptor inhibitor activity 3/308 44/18639 0.0681818181818182 4.12610684769776 0.0359694926079523 0.332178571157352 GO:0140597 protein carrier chaperone 7/308 188/18639 0.0372340425531915 2.25326402321083 0.0370268485001363 0.332178571157352 GO:0008009 chemokine activity 3/308 45/18639 0.0666666666666667 4.03441558441558 0.0380818846482859 0.332178571157352 GO:0042605 peptide antigen binding 3/308 45/18639 0.0666666666666667 4.03441558441558 0.0380818846482859 0.332178571157352 GO:0140303 intramembrane lipid transporter activity 3/308 45/18639 0.0666666666666667 4.03441558441558 0.0380818846482859 0.332178571157352 GO:0003724 RNA helicase activity 4/308 77/18639 0.051948051948052 3.14370045538877 0.038665877443261 0.332178571157352 GO:0046527 glucosyltransferase activity 2/308 19/18639 0.105263157894737 6.37012987012987 0.0386805125019741 0.332178571157352 GO:0000510 H3-H4 histone complex chaperone activity 6/308 151/18639 0.0397350993377483 2.4046185602477 0.0396513453198341 0.332178571157352 GO:0140584 chromatin extrusion motor activity 6/308 151/18639 0.0397350993377483 2.4046185602477 0.0396513453198341 0.332178571157352 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 6/308 151/18639 0.0397350993377483 2.4046185602477 0.0396513453198341 0.332178571157352 GO:0140849 ATP-dependent H2AZ histone chaperone activity 6/308 151/18639 0.0397350993377483 2.4046185602477 0.0396513453198341 0.332178571157352 GO:0015616 DNA translocase activity 6/308 152/18639 0.0394736842105263 2.3887987012987 0.0407335246742181 0.332178571157352 GO:0140674 ATP-dependent histone chaperone activity 6/308 152/18639 0.0394736842105263 2.3887987012987 0.0407335246742181 0.332178571157352 GO:0061775 cohesin loader activity 6/308 153/18639 0.0392156862745098 2.37318563789152 0.0418342332791763 0.332178571157352 GO:0008186 ATP-dependent activity, acting on RNA 4/308 79/18639 0.0506329113924051 3.06411310208779 0.0418626836611326 0.332178571157352 GO:0043495 protein-membrane adaptor activity 3/308 47/18639 0.0638297872340425 3.86273832550428 0.0424921929568505 0.332178571157352 GO:0000339 RNA cap binding 2/308 20/18639 0.1 6.05162337662338 0.0425188571081411 0.332178571157352 GO:0016505 peptidase activator activity involved in apoptotic process 2/308 20/18639 0.1 6.05162337662338 0.0425188571081411 0.332178571157352 GO:0048306 calcium-dependent protein binding 4/308 80/18639 0.05 3.02581168831169 0.0435155212177625 0.335767910630884 GO:0004857 enzyme inhibitor activity 12/308 416/18639 0.0288461538461538 1.74566058941059 0.0445177778552366 0.339312331213694 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/308 21/18639 0.0952380952380952 5.76345083487941 0.0464928171983 0.350096515047439 GO:0140658 ATP-dependent chromatin remodeler activity 6/308 158/18639 0.0379746835443038 2.29808482656584 0.0476179384373019 0.351367324343932 GO:0003924 GTPase activity 10/308 331/18639 0.0302114803625378 1.82828500804332 0.0491409244056778 0.351367324343932 GO:0003689 DNA clamp loader activity 6/308 160/18639 0.0375 2.26935876623377 0.0500631846429268 0.351367324343932 GO:0015377 chloride:monoatomic cation symporter activity 2/308 22/18639 0.0909090909090909 5.50147579693034 0.0505968947055263 0.351367324343932 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/308 22/18639 0.0909090909090909 5.50147579693034 0.0505968947055263 0.351367324343932 GO:0061133 endopeptidase activator activity 2/308 22/18639 0.0909090909090909 5.50147579693034 0.0505968947055263 0.351367324343932 GO:0070034 telomerase RNA binding 2/308 22/18639 0.0909090909090909 5.50147579693034 0.0505968947055263 0.351367324343932 GO:0045296 cadherin binding 10/308 334/18639 0.029940119760479 1.81186328641418 0.05163143183668 0.35461148239478 GO:0140713 histone chaperone activity 6/308 164/18639 0.0365853658536585 2.21400855242319 0.0551814502070411 0.37487398238479 GO:0001664 G protein-coupled receptor binding 9/308 297/18639 0.0303030303030303 1.83382526564345 0.0591366380423548 0.37888731141484 GO:0050699 WW domain binding 2/308 24/18639 0.0833333333333333 5.04301948051948 0.0591741246429046 0.37888731141484 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 13/308 484/18639 0.0268595041322314 1.62543603091124 0.0595968117121341 0.37888731141484 GO:0003925 G protein activity 3/308 54/18639 0.0555555555555556 3.36201298701299 0.0598222281236507 0.37888731141484 GO:0140463 chromatin-protein adaptor activity 3/308 54/18639 0.0555555555555556 3.36201298701299 0.0598222281236507 0.37888731141484 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/308 89/18639 0.0449438202247191 2.71983073106669 0.0600157501281106 0.37888731141484 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/308 89/18639 0.0449438202247191 2.71983073106669 0.0600157501281106 0.37888731141484 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 5/308 128/18639 0.0390625 2.36391538149351 0.0614064740837694 0.382433811808503 GO:0140793 histone H2AXY142 phosphatase activity 4/308 90/18639 0.0444444444444444 2.68961038961039 0.0620279207218299 0.382433811808503 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/308 25/18639 0.08 4.8412987012987 0.0636369862849349 0.382433811808503 GO:0015645 fatty acid ligase activity 2/308 25/18639 0.08 4.8412987012987 0.0636369862849349 0.382433811808503 GO:0120515 fatty acid-CoA ligase activity 2/308 25/18639 0.08 4.8412987012987 0.0636369862849349 0.382433811808503 GO:0031625 ubiquitin protein ligase binding 9/308 302/18639 0.0298013245033113 1.80346392018577 0.0642603803973704 0.382502264270062 GO:0001216 DNA-binding transcription activator activity 13/308 491/18639 0.0264765784114053 1.60226280847462 0.0651611970692255 0.384205171398735 GO:0004435 phosphatidylinositol phospholipase C activity 2/308 26/18639 0.0769230769230769 4.65509490509491 0.0682093775261989 0.39110881609059 GO:0008157 protein phosphatase 1 binding 2/308 26/18639 0.0769230769230769 4.65509490509491 0.0682093775261989 0.39110881609059 GO:0043548 phosphatidylinositol 3-kinase binding 2/308 26/18639 0.0769230769230769 4.65509490509491 0.0682093775261989 0.39110881609059 GO:0004721 phosphoprotein phosphatase activity 6/308 175/18639 0.0342857142857143 2.07484230055659 0.0708326839992818 0.402458431814101 GO:0016405 CoA-ligase activity 2/308 27/18639 0.0740740740740741 4.48268398268398 0.0728864869181278 0.410396885800269 GO:0045309 protein phosphorylated amino acid binding 3/308 59/18639 0.0508474576271186 3.07709663218138 0.073916302327253 0.412479365665474 GO:0002020 protease binding 5/308 136/18639 0.0367647058823529 2.2248615355233 0.075348962586418 0.413097382600976 GO:0140789 histone phosphatase activity 5/308 136/18639 0.0367647058823529 2.2248615355233 0.075348962586418 0.413097382600976 GO:0046625 sphingolipid binding 2/308 28/18639 0.0714285714285714 4.32258812615955 0.0776636311969917 0.422084952157563 GO:0004725 protein tyrosine phosphatase activity 4/308 98/18639 0.0408163265306122 2.47005035780546 0.0793790236941884 0.422829161804102 GO:0042578 phosphoric ester hydrolase activity 10/308 363/18639 0.0275482093663912 1.66711387785768 0.0800699817857306 0.422829161804102 GO:0070851 growth factor receptor binding 5/308 139/18639 0.0359712230215827 2.17684294123143 0.0809847642817995 0.422829161804102 GO:0004629 phospholipase C activity 2/308 29/18639 0.0689655172413793 4.17353336318854 0.0825362523841607 0.422829161804102 GO:0035250 UDP-galactosyltransferase activity 2/308 29/18639 0.0689655172413793 4.17353336318854 0.0825362523841607 0.422829161804102 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/308 29/18639 0.0689655172413793 4.17353336318854 0.0825362523841607 0.422829161804102 GO:0051861 glycolipid binding 2/308 29/18639 0.0689655172413793 4.17353336318854 0.0825362523841607 0.422829161804102 GO:0016791 phosphatase activity 8/308 273/18639 0.0293040293040293 1.7733694876552 0.0842701420038715 0.428201941076583 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/308 30/18639 0.0666666666666667 4.03441558441558 0.0874999149467007 0.441027797110387 GO:0019903 protein phosphatase binding 5/308 144/18639 0.0347222222222222 2.10125811688312 0.0908621188456473 0.45241249476644 GO:0001217 DNA-binding transcription repressor activity 8/308 278/18639 0.0287769784172662 1.74147435298514 0.0912063589449144 0.45241249476644 GO:0016878 acid-thiol ligase activity 2/308 31/18639 0.0645161290322581 3.90427314620863 0.0925503030171097 0.453658329690657 GO:0008194 UDP-glycosyltransferase activity 5/308 145/18639 0.0344827586206897 2.08676668159427 0.0929092259206465 0.453658329690657 GO:0043177 organic acid binding 6/308 189/18639 0.0317460317460317 1.92115027829314 0.0940818225253896 0.455822783553244 GO:0019902 phosphatase binding 6/308 190/18639 0.0315789473684211 1.91103896103896 0.0958828396951361 0.460975190842 GO:0008378 galactosyltransferase activity 2/308 32/18639 0.0625 3.78226461038961 0.0976832176710283 0.466045885835059 GO:0005548 phospholipid transporter activity 3/308 68/18639 0.0441176470588235 2.66983384262796 0.102550833127587 0.476080460573235 GO:1990841 promoter-specific chromatin binding 3/308 68/18639 0.0441176470588235 2.66983384262796 0.102550833127587 0.476080460573235 GO:0019239 deaminase activity 2/308 33/18639 0.0606060606060606 3.6676505312869 0.102894574261773 0.476080460573235 GO:0140311 protein sequestering activity 2/308 33/18639 0.0606060606060606 3.6676505312869 0.102894574261773 0.476080460573235 GO:0061631 ubiquitin conjugating enzyme activity 2/308 35/18639 0.0571428571428571 3.45807050092764 0.113536830451398 0.476080460573235 GO:0004386 helicase activity 5/308 155/18639 0.032258064516129 1.95213657310431 0.114653125385991 0.476080460573235 GO:0055106 ubiquitin-protein transferase regulator activity 2/308 36/18639 0.0555555555555556 3.36201298701299 0.118960108929308 0.476080460573235 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/308 36/18639 0.0555555555555556 3.36201298701299 0.118960108929308 0.476080460573235 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/308 36/18639 0.0555555555555556 3.36201298701299 0.118960108929308 0.476080460573235 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/308 36/18639 0.0555555555555556 3.36201298701299 0.118960108929308 0.476080460573235 GO:0140104 molecular carrier activity 7/308 249/18639 0.0281124497991968 1.7012595837897 0.119811166251262 0.476080460573235 GO:0003714 transcription corepressor activity 6/308 204/18639 0.0294117647058824 1.77988922841864 0.122991002268179 0.476080460573235 GO:0001221 transcription coregulator binding 4/308 115/18639 0.0347826086956522 2.10491247882552 0.123184414514062 0.476080460573235 GO:0017124 SH3 domain binding 4/308 115/18639 0.0347826086956522 2.10491247882552 0.123184414514062 0.476080460573235 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 9/308 349/18639 0.0257879656160458 1.56059055557623 0.125873493319984 0.476080460573235 GO:0004866 endopeptidase inhibitor activity 5/308 161/18639 0.031055900621118 1.8793861418085 0.128765552337725 0.476080460573235 GO:1990782 protein tyrosine kinase binding 4/308 117/18639 0.0341880341880342 2.06893106893107 0.12890401978859 0.476080460573235 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/308 39/18639 0.0512820512820513 3.1033966033966 0.135595006928065 0.476080460573235 GO:0008094 ATP-dependent activity, acting on DNA 6/308 210/18639 0.0285714285714286 1.72903525046382 0.135650162382679 0.476080460573235 GO:0046332 SMAD binding 3/308 79/18639 0.0379746835443038 2.29808482656584 0.142441913336707 0.476080460573235 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/308 122/18639 0.0327868852459016 1.98413881200766 0.143672269949894 0.476080460573235 GO:0001530 lipopolysaccharide binding 2/308 41/18639 0.0487804878048781 2.95201140323092 0.146954873410725 0.476080460573235 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/308 41/18639 0.0487804878048781 2.95201140323092 0.146954873410725 0.476080460573235 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/308 41/18639 0.0487804878048781 2.95201140323092 0.146954873410725 0.476080460573235 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/308 41/18639 0.0487804878048781 2.95201140323092 0.146954873410725 0.476080460573235 GO:0030414 peptidase inhibitor activity 5/308 169/18639 0.029585798816568 1.79042111734419 0.148740401610965 0.476080460573235 GO:0015101 organic cation transmembrane transporter activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0033192 calmodulin-dependent protein phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0140791 histone H2AXS140 phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/308 81/18639 0.037037037037037 2.24134199134199 0.150184325351744 0.476080460573235 GO:0016859 cis-trans isomerase activity 2/308 42/18639 0.0476190476190476 2.8817254174397 0.152706004571384 0.476080460573235 GO:0035198 miRNA binding 2/308 42/18639 0.0476190476190476 2.8817254174397 0.152706004571384 0.476080460573235 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0005345 purine nucleobase transmembrane transporter activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0005528 FK506 binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0008140 cAMP response element binding protein binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0015203 polyamine transmembrane transporter activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0031434 mitogen-activated protein kinase kinase binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0043208 glycosphingolipid binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0043422 protein kinase B binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0050308 sugar-phosphatase activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0050815 phosphoserine residue binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0070513 death domain binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0071723 lipopeptide binding 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:1990757 ubiquitin ligase activator activity 1/308 10/18639 0.1 6.05162337662338 0.15351772713186 0.476080460573235 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/308 82/18639 0.0365853658536585 2.21400855242319 0.154105377062167 0.476080460573235 GO:0033549 MAP kinase phosphatase activity 3/308 82/18639 0.0365853658536585 2.21400855242319 0.154105377062167 0.476080460573235 GO:0016887 ATP hydrolysis activity 10/308 417/18639 0.0239808153477218 1.45122862748762 0.154492670913422 0.476080460573235 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 7/308 268/18639 0.0261194029850746 1.58064789687924 0.156818987747882 0.476080460573235 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/308 83/18639 0.036144578313253 2.18733375058676 0.158058398116976 0.476080460573235 GO:0046982 protein heterodimerization activity 9/308 369/18639 0.024390243902439 1.47600570161546 0.159244879594909 0.476080460573235 GO:0004860 protein kinase inhibitor activity 3/308 84/18639 0.0357142857142857 2.16129406307978 0.162042445567283 0.476080460573235 GO:0017018 myosin phosphatase activity 3/308 84/18639 0.0357142857142857 2.16129406307978 0.162042445567283 0.476080460573235 GO:0001046 core promoter sequence-specific DNA binding 2/308 44/18639 0.0454545454545455 2.75073789846517 0.164335276889008 0.476080460573235 GO:0001223 transcription coactivator binding 2/308 44/18639 0.0454545454545455 2.75073789846517 0.164335276889008 0.476080460573235 GO:0035591 signaling adaptor activity 4/308 129/18639 0.0310077519379845 1.87647236484446 0.165393440934906 0.476080460573235 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0005114 type II transforming growth factor beta receptor binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0005225 volume-sensitive anion channel activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0008199 ferric iron binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0008271 secondary active sulfate transmembrane transporter activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0015173 aromatic amino acid transmembrane transporter activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0015205 nucleobase transmembrane transporter activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0019107 myristoyltransferase activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0019203 carbohydrate phosphatase activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0019864 IgG binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0034713 type I transforming growth factor beta receptor binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0043522 leucine zipper domain binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0140031 phosphorylation-dependent protein binding 1/308 11/18639 0.0909090909090909 5.50147579693034 0.167512924944055 0.476080460573235 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/308 130/18639 0.0307692307692308 1.86203796203796 0.168588700915077 0.476080460573235 GO:0046915 transition metal ion transmembrane transporter activity 2/308 45/18639 0.0444444444444444 2.68961038961039 0.170207527690902 0.476080460573235 GO:0008017 microtubule binding 7/308 276/18639 0.0253623188405797 1.53483201581028 0.173808896059062 0.476080460573235 GO:0004180 carboxypeptidase activity 2/308 46/18639 0.0434782608695652 2.6311405985319 0.176114403222509 0.476080460573235 GO:0016853 isomerase activity 5/308 180/18639 0.0277777777777778 1.68100649350649 0.178174481041981 0.476080460573235 GO:0000340 RNA 7-methylguanosine cap binding 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0004000 adenosine deaminase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0004859 phospholipase inhibitor activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0004875 complement receptor activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0005527 macrolide binding 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0015166 polyol transmembrane transporter activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0035259 nuclear glucocorticoid receptor binding 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0035497 cAMP response element binding 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0070008 serine-type exopeptidase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0140900 chloride:bicarbonate antiporter activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:1990817 poly(A) RNA polymerase activity 1/308 12/18639 0.0833333333333333 5.04301948051948 0.181277473962588 0.476080460573235 GO:0000287 magnesium ion binding 6/308 230/18639 0.0260869565217391 1.57868435911914 0.18192916049495 0.476080460573235 GO:0001784 phosphotyrosine residue binding 2/308 47/18639 0.0425531914893617 2.57515888366952 0.182053168123205 0.476080460573235 GO:0005504 fatty acid binding 2/308 47/18639 0.0425531914893617 2.57515888366952 0.182053168123205 0.476080460573235 GO:0019210 kinase inhibitor activity 3/308 90/18639 0.0333333333333333 2.01720779220779 0.186545905399303 0.485796628644018 GO:0140693 molecular condensate scaffold activity 2/308 48/18639 0.0416666666666667 2.52150974025974 0.188021167430743 0.486058320632837 GO:0019838 growth factor binding 4/308 136/18639 0.0294117647058824 1.77988922841864 0.188201781749034 0.486058320632837 GO:0001222 transcription corepressor binding 2/308 49/18639 0.0408163265306122 2.47005035780546 0.194015824685671 0.490965633144916 GO:0005172 vascular endothelial growth factor receptor binding 1/308 13/18639 0.0769230769230769 4.65509490509491 0.194815163231903 0.490965633144916 GO:0089720 caspase binding 1/308 13/18639 0.0769230769230769 4.65509490509491 0.194815163231903 0.490965633144916 GO:0140333 glycerophospholipid flippase activity 1/308 13/18639 0.0769230769230769 4.65509490509491 0.194815163231903 0.490965633144916 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/308 13/18639 0.0769230769230769 4.65509490509491 0.194815163231903 0.490965633144916 GO:0140852 histone ubiquitin ligase activity 1/308 13/18639 0.0769230769230769 4.65509490509491 0.194815163231903 0.490965633144916 GO:0031406 carboxylic acid binding 5/308 187/18639 0.0267379679144385 1.61808111674422 0.197959610828286 0.494156719555635 GO:0019207 kinase regulator activity 7/308 287/18639 0.024390243902439 1.47600570161546 0.198394731023078 0.494156719555635 GO:0051219 phosphoprotein binding 3/308 93/18639 0.032258064516129 1.95213657310431 0.199141276404918 0.494156719555635 GO:0003779 actin binding 10/308 443/18639 0.0225733634311512 1.3660549382897 0.199598242573665 0.494156719555635 GO:0048020 CCR chemokine receptor binding 2/308 50/18639 0.04 2.42064935064935 0.200034640076121 0.494156719555635 GO:0005543 phospholipid binding 11/308 497/18639 0.0221327967806841 1.33939350388043 0.201639386395153 0.496159907468388 GO:0005161 platelet-derived growth factor receptor binding 1/308 14/18639 0.0714285714285714 4.32258812615955 0.208129719750993 0.497522083199701 GO:0005545 1-phosphatidylinositol binding 1/308 14/18639 0.0714285714285714 4.32258812615955 0.208129719750993 0.497522083199701 GO:0019763 immunoglobulin receptor activity 1/308 14/18639 0.0714285714285714 4.32258812615955 0.208129719750993 0.497522083199701 GO:0042043 neurexin family protein binding 1/308 14/18639 0.0714285714285714 4.32258812615955 0.208129719750993 0.497522083199701 GO:0098847 sequence-specific single stranded DNA binding 1/308 14/18639 0.0714285714285714 4.32258812615955 0.208129719750993 0.497522083199701 GO:0005080 protein kinase C binding 2/308 52/18639 0.0384615384615385 2.32754745254745 0.212135118398817 0.497522083199701 GO:0030159 signaling receptor complex adaptor activity 2/308 52/18639 0.0384615384615385 2.32754745254745 0.212135118398817 0.497522083199701 GO:0004864 protein phosphatase inhibitor activity 2/308 53/18639 0.0377358490566038 2.28363146287675 0.218212148797316 0.497522083199701 GO:0015116 sulfate transmembrane transporter activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0015250 water channel activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0016846 carbon-sulfur lyase activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0031005 filamin binding 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0031386 protein tag activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0034483 heparan sulfate sulfotransferase activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0048531 beta-1,3-galactosyltransferase activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0050780 dopamine receptor binding 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0061578 K63-linked deubiquitinase activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0120283 protein serine/threonine kinase binding 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0140161 monocarboxylate:sodium symporter activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0141047 molecular tag activity 1/308 15/18639 0.0666666666666667 4.03441558441558 0.221224809486117 0.497522083199701 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/308 54/18639 0.037037037037037 2.24134199134199 0.224304068823226 0.497522083199701 GO:0033218 amide binding 6/308 247/18639 0.0242914979757085 1.47002997002997 0.225509282067589 0.497522083199701 GO:0042393 histone binding 6/308 247/18639 0.0242914979757085 1.47002997002997 0.225509282067589 0.497522083199701 GO:0016758 hexosyltransferase activity 5/308 197/18639 0.0253807106598985 1.53594501944756 0.227440728267211 0.497522083199701 GO:0042277 peptide binding 6/308 249/18639 0.0240963855421687 1.45822250039118 0.230850395671606 0.497522083199701 GO:0008509 monoatomic anion transmembrane transporter activity 4/308 149/18639 0.0268456375838926 1.62459687963044 0.232927508290927 0.497522083199701 GO:0004708 MAP kinase kinase activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0005149 interleukin-1 receptor binding 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0008142 oxysterol binding 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0015378 sodium:chloride symporter activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0016722 oxidoreductase activity, acting on metal ions 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0022858 alanine transmembrane transporter activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0030275 LRR domain binding 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0034450 ubiquitin-ubiquitin ligase activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0055102 lipase inhibitor activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0097027 ubiquitin-protein transferase activator activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0140327 flippase activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0140328 floppase activity 1/308 16/18639 0.0625 3.78226461038961 0.234104038367038 0.497522083199701 GO:0019212 phosphatase inhibitor activity 2/308 56/18639 0.0357142857142857 2.16129406307978 0.23652407189601 0.497522083199701 GO:0004722 protein serine/threonine phosphatase activity 3/308 103/18639 0.029126213592233 1.76260875047283 0.24241263492597 0.497522083199701 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0004550 nucleoside diphosphate kinase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0016018 cyclosporin A binding 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0016805 dipeptidase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0017110 nucleoside diphosphate phosphatase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0019198 transmembrane receptor protein phosphatase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0032183 SUMO binding 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0032977 membrane insertase activity 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0038191 neuropilin binding 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0045236 CXCR chemokine receptor binding 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0070403 NAD+ binding 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0070492 oligosaccharide binding 1/308 17/18639 0.0588235294117647 3.55977845683728 0.246770953267052 0.497522083199701 GO:0061980 regulatory RNA binding 2/308 58/18639 0.0344827586206897 2.08676668159427 0.248778769558891 0.49995733432253 GO:0005516 calmodulin binding 5/308 207/18639 0.0241545893719807 1.46174477696217 0.258110458882984 0.503161962280805 GO:0000900 mRNA regulatory element binding translation repressor activity 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0004706 JUN kinase kinase kinase activity 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0005372 water transmembrane transporter activity 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0015373 monoatomic anion:sodium symporter activity 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0016854 racemase and epimerase activity 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0031690 adrenergic receptor binding 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0050811 GABA receptor binding 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:1990381 ubiquitin-specific protease binding 1/308 18/18639 0.0555555555555556 3.36201298701299 0.259229042967071 0.503161962280805 GO:0008574 plus-end-directed microtubule motor activity 1/308 19/18639 0.0526315789473684 3.18506493506493 0.27148173910402 0.518887116024503 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/308 19/18639 0.0526315789473684 3.18506493506493 0.27148173910402 0.518887116024503 GO:0042834 peptidoglycan binding 1/308 19/18639 0.0526315789473684 3.18506493506493 0.27148173910402 0.518887116024503 GO:0050145 nucleoside monophosphate kinase activity 1/308 19/18639 0.0526315789473684 3.18506493506493 0.27148173910402 0.518887116024503 GO:0097001 ceramide binding 1/308 19/18639 0.0526315789473684 3.18506493506493 0.27148173910402 0.518887116024503 GO:0005507 copper ion binding 2/308 63/18639 0.0317460317460317 1.92115027829314 0.279468944295803 0.530562157754124 GO:1901682 sulfur compound transmembrane transporter activity 2/308 63/18639 0.0317460317460317 1.92115027829314 0.279468944295803 0.530562157754124 GO:0001614 purinergic nucleotide receptor activity 1/308 20/18639 0.05 3.02581168831169 0.283532417103804 0.530562157754124 GO:0015095 magnesium ion transmembrane transporter activity 1/308 20/18639 0.05 3.02581168831169 0.283532417103804 0.530562157754124 GO:0016004 phospholipase activator activity 1/308 20/18639 0.05 3.02581168831169 0.283532417103804 0.530562157754124 GO:0016502 nucleotide receptor activity 1/308 20/18639 0.05 3.02581168831169 0.283532417103804 0.530562157754124 GO:0052745 inositol phosphate phosphatase activity 1/308 20/18639 0.05 3.02581168831169 0.283532417103804 0.530562157754124 GO:0005525 GTP binding 8/308 378/18639 0.0211640211640212 1.28076685219542 0.288515830169508 0.537112579404306 GO:0140297 DNA-binding transcription factor binding 10/308 488/18639 0.0204918032786885 1.24008675750479 0.288751722687755 0.537112579404306 GO:0005096 GTPase activator activity 6/308 271/18639 0.022140221402214 1.33984281401256 0.291908963714863 0.541374190865843 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/308 21/18639 0.0476190476190476 2.8817254174397 0.295384397099079 0.541393689697725 GO:0015125 bile acid transmembrane transporter activity 1/308 21/18639 0.0476190476190476 2.8817254174397 0.295384397099079 0.541393689697725 GO:0019200 carbohydrate kinase activity 1/308 21/18639 0.0476190476190476 2.8817254174397 0.295384397099079 0.541393689697725 GO:0035613 RNA stem-loop binding 1/308 21/18639 0.0476190476190476 2.8817254174397 0.295384397099079 0.541393689697725 GO:0008235 metalloexopeptidase activity 2/308 66/18639 0.0303030303030303 1.83382526564345 0.297851726152115 0.54431967498559 GO:0003712 transcription coregulator activity 10/308 495/18639 0.0202020202020202 1.22255017709563 0.303572893710272 0.553157605157201 GO:0008093 cytoskeletal anchor activity 1/308 22/18639 0.0454545454545455 2.75073789846517 0.307040944832105 0.5578505538374 GO:0030145 manganese ion binding 2/308 68/18639 0.0294117647058824 1.77988922841864 0.31006825885759 0.561717860249258 GO:0004602 glutathione peroxidase activity 1/308 23/18639 0.0434782608695652 2.6311405985319 0.318505272542892 0.568759415255164 GO:0005158 insulin receptor binding 1/308 23/18639 0.0434782608695652 2.6311405985319 0.318505272542892 0.568759415255164 GO:0005283 amino acid:sodium symporter activity 1/308 23/18639 0.0434782608695652 2.6311405985319 0.318505272542892 0.568759415255164 GO:0031681 G-protein beta-subunit binding 1/308 23/18639 0.0434782608695652 2.6311405985319 0.318505272542892 0.568759415255164 GO:0043274 phospholipase binding 1/308 23/18639 0.0434782608695652 2.6311405985319 0.318505272542892 0.568759415255164 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/308 70/18639 0.0285714285714286 1.72903525046382 0.322240945819703 0.572157872286432 GO:0003697 single-stranded DNA binding 3/308 121/18639 0.0247933884297521 1.50040249007191 0.323154766267377 0.572157872286432 GO:0015108 chloride transmembrane transporter activity 3/308 121/18639 0.0247933884297521 1.50040249007191 0.323154766267377 0.572157872286432 GO:0035091 phosphatidylinositol binding 6/308 284/18639 0.0211267605633803 1.27851198097677 0.329446549276965 0.572535659449464 GO:0005540 hyaluronic acid binding 1/308 24/18639 0.0416666666666667 2.52150974025974 0.329780539842891 0.572535659449464 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/308 24/18639 0.0416666666666667 2.52150974025974 0.329780539842891 0.572535659449464 GO:0035035 histone acetyltransferase binding 1/308 24/18639 0.0416666666666667 2.52150974025974 0.329780539842891 0.572535659449464 GO:0050431 transforming growth factor beta binding 1/308 24/18639 0.0416666666666667 2.52150974025974 0.329780539842891 0.572535659449464 GO:0060229 lipase activator activity 1/308 24/18639 0.0416666666666667 2.52150974025974 0.329780539842891 0.572535659449464 GO:0070840 dynein complex binding 1/308 24/18639 0.0416666666666667 2.52150974025974 0.329780539842891 0.572535659449464 GO:0005085 guanyl-nucleotide exchange factor activity 5/308 230/18639 0.0217391304347826 1.31557029926595 0.331684591447896 0.574246176329461 GO:0043021 ribonucleoprotein complex binding 4/308 177/18639 0.0225988700564972 1.36759850319172 0.335686659990213 0.574952768896976 GO:0005319 lipid transporter activity 4/308 178/18639 0.0224719101123595 1.35991536553334 0.339434275123703 0.574952768896976 GO:0004709 MAP kinase kinase kinase activity 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0015662 P-type ion transporter activity 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0019707 protein-cysteine S-acyltransferase activity 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0140358 P-type transmembrane transporter activity 1/308 25/18639 0.04 2.42064935064935 0.340869854574473 0.574952768896976 GO:0019001 guanyl nucleotide binding 8/308 400/18639 0.02 1.21032467532468 0.34221188804748 0.574952768896976 GO:0032561 guanyl ribonucleotide binding 8/308 400/18639 0.02 1.21032467532468 0.34221188804748 0.574952768896976 GO:0005112 Notch binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0005160 transforming growth factor beta receptor binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0008143 poly(A) binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0008198 ferrous iron binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0019865 immunoglobulin binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0030247 polysaccharide binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0070412 R-SMAD binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0097602 cullin family protein binding 1/308 26/18639 0.0384615384615385 2.32754745254745 0.351776273656404 0.577060816365492 GO:0051536 iron-sulfur cluster binding 2/308 76/18639 0.0263157894736842 1.59253246753247 0.358397190380126 0.57944821597757 GO:0004364 glutathione transferase activity 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0008266 poly(U) RNA binding 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0008320 protein transmembrane transporter activity 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0015252 proton channel activity 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0023026 MHC class II protein complex binding 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0035255 ionotropic glutamate receptor binding 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/308 27/18639 0.037037037037037 2.24134199134199 0.362502803915568 0.57944821597757 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/308 130/18639 0.0230769230769231 1.39652847152847 0.363814260023651 0.579450936604389 GO:0051540 metal cluster binding 2/308 77/18639 0.025974025974026 1.57185022769438 0.36435874893684 0.579450936604389 GO:0031072 heat shock protein binding 3/308 131/18639 0.0229007633587786 1.38586794884505 0.368314460194023 0.581649793541653 GO:0005539 glycosaminoglycan binding 5/308 242/18639 0.0206611570247934 1.25033540839326 0.370921719437954 0.581649793541653 GO:0019789 SUMO transferase activity 1/308 28/18639 0.0357142857142857 2.16129406307978 0.373052402905144 0.581649793541653 GO:0046875 ephrin receptor binding 1/308 28/18639 0.0357142857142857 2.16129406307978 0.373052402905144 0.581649793541653 GO:0046966 nuclear thyroid hormone receptor binding 1/308 28/18639 0.0357142857142857 2.16129406307978 0.373052402905144 0.581649793541653 GO:0050698 proteoglycan sulfotransferase activity 1/308 28/18639 0.0357142857142857 2.16129406307978 0.373052402905144 0.581649793541653 GO:0051537 2 iron, 2 sulfur cluster binding 1/308 28/18639 0.0357142857142857 2.16129406307978 0.373052402905144 0.581649793541653 GO:0008234 cysteine-type peptidase activity 4/308 187/18639 0.0213903743315508 1.29446489339537 0.373186507536324 0.581649793541653 GO:0033293 monocarboxylic acid binding 2/308 79/18639 0.0253164556962025 1.53205655104389 0.376217548392427 0.584915342649917 GO:0004181 metallocarboxypeptidase activity 1/308 29/18639 0.0344827586206897 2.08676668159427 0.383427979709466 0.590252431818759 GO:0005416 amino acid:monoatomic cation symporter activity 1/308 29/18639 0.0344827586206897 2.08676668159427 0.383427979709466 0.590252431818759 GO:0016417 S-acyltransferase activity 1/308 29/18639 0.0344827586206897 2.08676668159427 0.383427979709466 0.590252431818759 GO:0099604 ligand-gated calcium channel activity 1/308 29/18639 0.0344827586206897 2.08676668159427 0.383427979709466 0.590252431818759 GO:0001618 virus receptor activity 2/308 81/18639 0.0246913580246914 1.49422799422799 0.387984579083845 0.594339122371086 GO:0030971 receptor tyrosine kinase binding 2/308 81/18639 0.0246913580246914 1.49422799422799 0.387984579083845 0.594339122371086 GO:0001968 fibronectin binding 1/308 30/18639 0.0333333333333333 2.01720779220779 0.393632395735768 0.59599206890797 GO:0008187 poly-pyrimidine tract binding 1/308 30/18639 0.0333333333333333 2.01720779220779 0.393632395735768 0.59599206890797 GO:0031624 ubiquitin conjugating enzyme binding 1/308 30/18639 0.0333333333333333 2.01720779220779 0.393632395735768 0.59599206890797 GO:0051721 protein phosphatase 2A binding 1/308 30/18639 0.0333333333333333 2.01720779220779 0.393632395735768 0.59599206890797 GO:0140272 exogenous protein binding 2/308 82/18639 0.024390243902439 1.47600570161546 0.393831559134387 0.59599206890797 GO:0016922 nuclear receptor binding 3/308 137/18639 0.0218978102189781 1.3251730021803 0.395181326042296 0.596590166126654 GO:0001540 amyloid-beta binding 2/308 83/18639 0.0240963855421687 1.45822250039118 0.399653118665681 0.599000477616428 GO:0008135 translation factor activity, RNA binding 2/308 83/18639 0.0240963855421687 1.45822250039118 0.399653118665681 0.599000477616428 GO:0030165 PDZ domain binding 2/308 83/18639 0.0240963855421687 1.45822250039118 0.399653118665681 0.599000477616428 GO:0005452 solute:inorganic anion antiporter activity 1/308 31/18639 0.032258064516129 1.95213657310431 0.403668465493056 0.603571270175024 GO:0180051 translation factor activity 2/308 84/18639 0.0238095238095238 1.44086270871985 0.405448500936373 0.604785950084089 GO:0019887 protein kinase regulator activity 5/308 255/18639 0.0196078431372549 1.18659281894576 0.413451909801734 0.60957983101162 GO:0015106 bicarbonate transmembrane transporter activity 1/308 32/18639 0.03125 1.89113230519481 0.413538957358283 0.60957983101162 GO:0022884 macromolecule transmembrane transporter activity 1/308 32/18639 0.03125 1.89113230519481 0.413538957358283 0.60957983101162 GO:0030515 snoRNA binding 1/308 32/18639 0.03125 1.89113230519481 0.413538957358283 0.60957983101162 GO:0070717 poly-purine tract binding 1/308 32/18639 0.03125 1.89113230519481 0.413538957358283 0.60957983101162 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2/308 86/18639 0.0232558139534884 1.40735427363334 0.416957864736828 0.611733956480089 GO:0016209 antioxidant activity 2/308 86/18639 0.0232558139534884 1.40735427363334 0.416957864736828 0.611733956480089 GO:0030695 GTPase regulator activity 9/308 489/18639 0.0184049079754601 1.11379571348897 0.418887796078847 0.613126165220795 GO:0060589 nucleoside-triphosphatase regulator activity 9/308 490/18639 0.0183673469387755 1.11152266101246 0.421243925075609 0.613756662311556 GO:0008081 phosphoric diester hydrolase activity 2/308 87/18639 0.0229885057471264 1.39117778772951 0.422670488297338 0.613756662311556 GO:0030296 protein tyrosine kinase activator activity 1/308 33/18639 0.0303030303030303 1.83382526564345 0.423246594330049 0.613756662311556 GO:0140416 transcription regulator inhibitor activity 1/308 33/18639 0.0303030303030303 1.83382526564345 0.423246594330049 0.613756662311556 GO:0004197 cysteine-type endopeptidase activity 2/308 88/18639 0.0227272727272727 1.37536894923259 0.42835421704043 0.619725429745992 GO:0008376 acetylgalactosaminyltransferase activity 1/308 34/18639 0.0294117647058824 1.77988922841864 0.432794054770033 0.620404321631355 GO:0015035 protein-disulfide reductase activity 1/308 34/18639 0.0294117647058824 1.77988922841864 0.432794054770033 0.620404321631355 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/308 34/18639 0.0294117647058824 1.77988922841864 0.432794054770033 0.620404321631355 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/308 34/18639 0.0294117647058824 1.77988922841864 0.432794054770033 0.620404321631355 GO:0000175 3'-5'-RNA exonuclease activity 1/308 35/18639 0.0285714285714286 1.72903525046382 0.442183973132346 0.628102234562992 GO:0005154 epidermal growth factor receptor binding 1/308 35/18639 0.0285714285714286 1.72903525046382 0.442183973132346 0.628102234562992 GO:0005343 organic acid:sodium symporter activity 1/308 35/18639 0.0285714285714286 1.72903525046382 0.442183973132346 0.628102234562992 GO:0140566 histone reader activity 1/308 35/18639 0.0285714285714286 1.72903525046382 0.442183973132346 0.628102234562992 GO:0019209 kinase activator activity 3/308 148/18639 0.0202702702702703 1.22668041418041 0.443572838446682 0.628646312991329 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/308 36/18639 0.0277777777777778 1.68100649350649 0.451418940681004 0.634015366125006 GO:0005484 SNAP receptor activity 1/308 36/18639 0.0277777777777778 1.68100649350649 0.451418940681004 0.634015366125006 GO:0016409 palmitoyltransferase activity 1/308 36/18639 0.0277777777777778 1.68100649350649 0.451418940681004 0.634015366125006 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/308 36/18639 0.0277777777777778 1.68100649350649 0.451418940681004 0.634015366125006 GO:0015631 tubulin binding 7/308 385/18639 0.0181818181818182 1.10029515938607 0.452679946322584 0.63436091132649 GO:0023023 MHC protein complex binding 1/308 37/18639 0.027027027027027 1.63557388557389 0.46050150619572 0.642440717348939 GO:0043394 proteoglycan binding 1/308 37/18639 0.027027027027027 1.63557388557389 0.46050150619572 0.642440717348939 GO:0005109 frizzled binding 1/308 38/18639 0.0263157894736842 1.59253246753247 0.469434176666191 0.650546253694833 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/308 38/18639 0.0263157894736842 1.59253246753247 0.469434176666191 0.650546253694833 GO:0042887 amide transmembrane transporter activity 1/308 38/18639 0.0263157894736842 1.59253246753247 0.469434176666191 0.650546253694833 GO:0000217 DNA secondary structure binding 1/308 39/18639 0.0256410256410256 1.5516983016983 0.47821941797509 0.659795002725013 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/308 39/18639 0.0256410256410256 1.5516983016983 0.47821941797509 0.659795002725013 GO:0140097 catalytic activity, acting on DNA 6/308 336/18639 0.0178571428571429 1.08064703153989 0.481633281606792 0.661494097241727 GO:0004532 RNA exonuclease activity 1/308 40/18639 0.025 1.51290584415584 0.486859655569911 0.661494097241727 GO:0015036 disulfide oxidoreductase activity 1/308 40/18639 0.025 1.51290584415584 0.486859655569911 0.661494097241727 GO:0015144 carbohydrate transmembrane transporter activity 1/308 40/18639 0.025 1.51290584415584 0.486859655569911 0.661494097241727 GO:0061791 GTPase motor activity 1/308 40/18639 0.025 1.51290584415584 0.486859655569911 0.661494097241727 GO:0071855 neuropeptide receptor binding 1/308 40/18639 0.025 1.51290584415584 0.486859655569911 0.661494097241727 GO:1990606 membrane scission GTPase motor activity 1/308 40/18639 0.025 1.51290584415584 0.486859655569911 0.661494097241727 GO:0030246 carbohydrate binding 5/308 280/18639 0.0178571428571429 1.08064703153989 0.493639883602189 0.665802789145014 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/308 41/18639 0.024390243902439 1.47600570161546 0.49535727512389 0.665802789145014 GO:0008227 G protein-coupled amine receptor activity 1/308 41/18639 0.024390243902439 1.47600570161546 0.49535727512389 0.665802789145014 GO:0042169 SH2 domain binding 1/308 41/18639 0.024390243902439 1.47600570161546 0.49535727512389 0.665802789145014 GO:0140318 protein transporter activity 1/308 41/18639 0.024390243902439 1.47600570161546 0.49535727512389 0.665802789145014 GO:0005178 integrin binding 3/308 161/18639 0.0186335403726708 1.1276316850851 0.498695187965053 0.668167985650085 GO:0019894 kinesin binding 1/308 42/18639 0.0238095238095238 1.44086270871985 0.503714623186147 0.668167985650085 GO:0042056 chemoattractant activity 1/308 42/18639 0.0238095238095238 1.44086270871985 0.503714623186147 0.668167985650085 GO:0048487 beta-tubulin binding 1/308 42/18639 0.0238095238095238 1.44086270871985 0.503714623186147 0.668167985650085 GO:0051879 Hsp90 protein binding 1/308 42/18639 0.0238095238095238 1.44086270871985 0.503714623186147 0.668167985650085 GO:0008238 exopeptidase activity 2/308 102/18639 0.0196078431372549 1.18659281894576 0.504600462762944 0.668167985650085 GO:0015171 amino acid transmembrane transporter activity 2/308 102/18639 0.0196078431372549 1.18659281894576 0.504600462762944 0.668167985650085 GO:0005253 monoatomic anion channel activity 2/308 103/18639 0.0194174757281553 1.17507250031522 0.509792300937934 0.673597378712146 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/308 43/18639 0.0232558139534884 1.40735427363334 0.511934007821231 0.673597378712146 GO:0008375 acetylglucosaminyltransferase activity 1/308 43/18639 0.0232558139534884 1.40735427363334 0.511934007821231 0.673597378712146 GO:0015103 inorganic anion transmembrane transporter activity 3/308 165/18639 0.0181818181818182 1.10029515938607 0.515102230036595 0.676342213808555 GO:0019205 nucleobase-containing compound kinase activity 1/308 44/18639 0.0227272727272727 1.37536894923259 0.52001769923826 0.68136490990338 GO:0016874 ligase activity 3/308 167/18639 0.0179640718562874 1.08711797184851 0.52319807427378 0.684097900462579 GO:0000149 SNARE binding 2/308 106/18639 0.0188679245283019 1.14181573143837 0.525152969351484 0.68522047149202 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/308 45/18639 0.0222222222222222 1.34480519480519 0.52796793040979 0.686029015605237 GO:0051539 4 iron, 4 sulfur cluster binding 1/308 45/18639 0.0222222222222222 1.34480519480519 0.52796793040979 0.686029015605237 GO:0004843 cysteine-type deubiquitinase activity 2/308 108/18639 0.0185185185185185 1.120670995671 0.53521216888577 0.693999181646486 GO:0004620 phospholipase activity 2/308 109/18639 0.018348623853211 1.11038961038961 0.54018682103203 0.698999509617017 GO:0008201 heparin binding 3/308 172/18639 0.0174418604651163 1.05551570522501 0.543109740505578 0.700356651245683 GO:0140359 ABC-type transporter activity 1/308 47/18639 0.0212765957446809 1.28757944183476 0.54347676136665 0.700356651245683 GO:0140030 modification-dependent protein binding 3/308 173/18639 0.0173410404624277 1.049414458374 0.547034295162599 0.701038414794072 GO:1902936 phosphatidylinositol bisphosphate binding 2/308 111/18639 0.018018018018018 1.09038259038259 0.550025433489105 0.701038414794072 GO:0003823 antigen binding 3/308 174/18639 0.0172413793103448 1.04338334079713 0.550939171652163 0.701038414794072 GO:0106310 protein serine kinase activity 6/308 361/18639 0.0166204986149584 1.00580997949419 0.551550886641523 0.701038414794072 GO:0005200 structural constituent of cytoskeleton 2/308 112/18639 0.0178571428571429 1.08064703153989 0.55488912053897 0.701038414794072 GO:0035254 glutamate receptor binding 1/308 49/18639 0.0204081632653061 1.23502517890273 0.558477642628558 0.701038414794072 GO:0035401 histone H3Y41 kinase activity 2/308 115/18639 0.0173913043478261 1.05245623941276 0.569256366066823 0.701038414794072 GO:0101005 deubiquitinase activity 2/308 115/18639 0.0173913043478261 1.05245623941276 0.569256366066823 0.701038414794072 GO:0140801 histone H2AXY142 kinase activity 2/308 115/18639 0.0173913043478261 1.05245623941276 0.569256366066823 0.701038414794072 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 4/308 243/18639 0.0164609053497942 0.996151996151996 0.572477220106497 0.701038414794072 GO:0003743 translation initiation factor activity 1/308 51/18639 0.0196078431372549 1.18659281894576 0.572987158292431 0.701038414794072 GO:0015294 solute:monoatomic cation symporter activity 2/308 116/18639 0.0172413793103448 1.04338334079713 0.573970550273079 0.701038414794072 GO:0004674 protein serine/threonine kinase activity 7/308 433/18639 0.0161662817551963 0.97832248582826 0.576503382983504 0.701038414794072 GO:0004676 3-phosphoinositide-dependent protein kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0004711 ribosomal protein S6 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0035175 histone H3S10 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0035979 histone H2AXS139 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0044022 histone H3S28 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0044023 histone H4S1 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0044024 histone H2AS1 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0044025 histone H2BS14 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0072354 histone H3T3 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0072371 histone H2AS121 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0072518 Rho-dependent protein serine/threonine kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0140823 histone H2BS36 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0140855 histone H3S57 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0140995 histone H2A kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0140997 histone H4 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0140998 histone H2B kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:1990244 histone H2AT120 kinase activity 4/308 245/18639 0.0163265306122449 0.988020143122184 0.578963371535171 0.701038414794072 GO:0004677 DNA-dependent protein kinase activity 4/308 246/18639 0.016260162601626 0.984003801076972 0.582185456387688 0.701038414794072 GO:0140857 histone H3T45 kinase activity 4/308 246/18639 0.016260162601626 0.984003801076972 0.582185456387688 0.701038414794072 GO:0035402 histone H3T11 kinase activity 4/308 247/18639 0.0161943319838057 0.98001998001998 0.585393407894716 0.701038414794072 GO:0035403 histone H3T6 kinase activity 4/308 247/18639 0.0161943319838057 0.98001998001998 0.585393407894716 0.701038414794072 GO:0005544 calcium-dependent phospholipid binding 1/308 53/18639 0.0188679245283019 1.14181573143837 0.587021352711214 0.701038414794072 GO:0008146 sulfotransferase activity 1/308 53/18639 0.0188679245283019 1.14181573143837 0.587021352711214 0.701038414794072 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/308 53/18639 0.0188679245283019 1.14181573143837 0.587021352711214 0.701038414794072 GO:0016860 intramolecular oxidoreductase activity 1/308 53/18639 0.0188679245283019 1.14181573143837 0.587021352711214 0.701038414794072 GO:0004679 AMP-activated protein kinase activity 4/308 248/18639 0.0161290322580645 0.976068286552157 0.588587125502292 0.701038414794072 GO:0008237 metallopeptidase activity 3/308 184/18639 0.016304347826087 0.986677724449463 0.588872268427021 0.701038414794072 GO:1901981 phosphatidylinositol phosphate binding 3/308 185/18639 0.0162162162162162 0.981344331344331 0.592551115918172 0.70296528769972 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/308 54/18639 0.0185185185185185 1.120670995671 0.593865075048723 0.70296528769972 GO:0051287 NAD binding 1/308 54/18639 0.0185185185185185 1.120670995671 0.593865075048723 0.70296528769972 GO:0046943 carboxylic acid transmembrane transporter activity 3/308 188/18639 0.0159574468085106 0.965684581376071 0.603459721510992 0.712972260764404 GO:0005342 organic acid transmembrane transporter activity 3/308 189/18639 0.0158730158730159 0.960575139146568 0.607052981913365 0.714707195179799 GO:0170055 lipid transmembrane transporter activity 1/308 56/18639 0.0178571428571429 1.08064703153989 0.607215233024757 0.714707195179799 GO:0004601 peroxidase activity 1/308 57/18639 0.0175438596491228 1.06168831168831 0.613725361003468 0.721011937269112 GO:0008408 3'-5' exonuclease activity 1/308 58/18639 0.0172413793103448 1.04338334079713 0.620127932783197 0.723688446911126 GO:0019783 ubiquitin-like protein peptidase activity 2/308 127/18639 0.015748031496063 0.95301155537376 0.623342090934144 0.723688446911126 GO:0042826 histone deacetylase binding 2/308 127/18639 0.015748031496063 0.95301155537376 0.623342090934144 0.723688446911126 GO:0008236 serine-type peptidase activity 3/308 194/18639 0.0154639175257732 0.93581804793145 0.624693813005395 0.723688446911126 GO:0001786 phosphatidylserine binding 1/308 59/18639 0.0169491525423729 1.02569887739379 0.626424719646271 0.723688446911126 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/308 59/18639 0.0169491525423729 1.02569887739379 0.626424719646271 0.723688446911126 GO:0031593 polyubiquitin modification-dependent protein binding 1/308 59/18639 0.0169491525423729 1.02569887739379 0.626424719646271 0.723688446911126 GO:0070063 RNA polymerase binding 1/308 59/18639 0.0169491525423729 1.02569887739379 0.626424719646271 0.723688446911126 GO:0070888 E-box binding 1/308 59/18639 0.0169491525423729 1.02569887739379 0.626424719646271 0.723688446911126 GO:0001653 peptide receptor activity 2/308 128/18639 0.015625 0.945566152597403 0.627604673498585 0.723713876266818 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/308 60/18639 0.0166666666666667 1.0086038961039 0.632617463798529 0.728150856121695 GO:0016298 lipase activity 2/308 130/18639 0.0153846153846154 0.931018981018981 0.636017544185148 0.729785053525011 GO:0017171 serine hydrolase activity 3/308 198/18639 0.0151515151515152 0.916912632821724 0.638412328628695 0.729785053525011 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/308 61/18639 0.0163934426229508 0.992069406003832 0.63870787884509 0.729785053525011 GO:0019905 syntaxin binding 1/308 61/18639 0.0163934426229508 0.992069406003832 0.63870787884509 0.729785053525011 GO:0005262 calcium channel activity 2/308 131/18639 0.0152671755725191 0.923911965896699 0.640167979595863 0.730118589867544 GO:0015179 L-amino acid transmembrane transporter activity 1/308 62/18639 0.0161290322580645 0.976068286552157 0.644697650258359 0.733945412407057 GO:0008514 organic anion transmembrane transporter activity 4/308 269/18639 0.0148698884758364 0.899869647081543 0.652221487260982 0.741160780978388 GO:0015297 antiporter activity 2/308 135/18639 0.0148148148148148 0.896536796536797 0.656398460282471 0.744553607398447 GO:0004175 endopeptidase activity 6/308 405/18639 0.0148148148148148 0.896536796536797 0.66283235139576 0.750489528301359 GO:1901681 sulfur compound binding 4/308 275/18639 0.0145454545454545 0.880236127508855 0.669152139706531 0.756031326451775 GO:0030295 protein kinase activator activity 2/308 139/18639 0.0143884892086331 0.870737176492572 0.672040102194913 0.756031326451775 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/308 67/18639 0.0149253731343284 0.90322736964528 0.673193932450091 0.756031326451775 GO:0050840 extracellular matrix binding 1/308 67/18639 0.0149253731343284 0.90322736964528 0.673193932450091 0.756031326451775 GO:0051015 actin filament binding 3/308 209/18639 0.0143540669856459 0.868654073199528 0.674311911683107 0.756031326451775 GO:0004713 protein tyrosine kinase activity 2/308 140/18639 0.0142857142857143 0.864517625231911 0.675859434750697 0.756031326451775 GO:0003777 microtubule motor activity 1/308 68/18639 0.0147058823529412 0.88994461420932 0.678613718623114 0.756031326451775 GO:0032934 sterol binding 1/308 68/18639 0.0147058823529412 0.88994461420932 0.678613718623114 0.756031326451775 GO:0140223 general transcription initiation factor activity 1/308 68/18639 0.0147058823529412 0.88994461420932 0.678613718623114 0.756031326451775 GO:0002039 p53 binding 1/308 69/18639 0.0144927536231884 0.877046866177301 0.683943909494046 0.760613778351919 GO:0016782 transferase activity, transferring sulphur-containing groups 1/308 70/18639 0.0142857142857143 0.864517625231911 0.689185981431355 0.76372559999042 GO:0097110 scaffold protein binding 1/308 70/18639 0.0142857142857143 0.864517625231911 0.689185981431355 0.76372559999042 GO:0015293 symporter activity 2/308 146/18639 0.0136986301369863 0.828989503647038 0.698021522872715 0.770640423921726 GO:0141003 histone H2AX kinase activity 5/308 354/18639 0.0141242937853107 0.854749064494827 0.698970158335408 0.770640423921726 GO:0005518 collagen binding 1/308 72/18639 0.0138888888888889 0.840503246753247 0.699411553127577 0.770640423921726 GO:0015291 secondary active transmembrane transporter activity 4/308 287/18639 0.0139372822299652 0.843431829494547 0.701295659288639 0.770640423921726 GO:0015085 calcium ion transmembrane transporter activity 2/308 147/18639 0.0136054421768707 0.823350119268487 0.70159104193834 0.770640423921726 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/308 73/18639 0.0136986301369863 0.828989503647038 0.704397885956612 0.771013447850933 GO:0043539 protein serine/threonine kinase activator activity 1/308 73/18639 0.0136986301369863 0.828989503647038 0.704397885956612 0.771013447850933 GO:0140996 histone H3 kinase activity 5/308 357/18639 0.0140056022408964 0.847566299246972 0.70595406723138 0.771365895139183 GO:0035064 methylated histone binding 1/308 74/18639 0.0135135135135135 0.817786942786943 0.709301766766984 0.773671211569573 GO:0035173 histone kinase activity 5/308 360/18639 0.0138888888888889 0.840503246753247 0.712824829005129 0.776159439247745 GO:0017022 myosin binding 1/308 76/18639 0.0131578947368421 0.796266233766234 0.718867586107421 0.780021252286698 GO:0140034 methylation-dependent protein binding 1/308 76/18639 0.0131578947368421 0.796266233766234 0.718867586107421 0.780021252286698 GO:0003774 cytoskeletal motor activity 2/308 153/18639 0.0130718954248366 0.791061879297173 0.722279042857087 0.782364647808804 GO:0005506 iron ion binding 2/308 154/18639 0.012987012987013 0.785925113847192 0.725607271044117 0.784609938412757 GO:0015370 solute:sodium symporter activity 1/308 79/18639 0.0126582278481013 0.766028275521946 0.732631182594974 0.790836768776958 GO:0000049 tRNA binding 1/308 80/18639 0.0125 0.756452922077922 0.737068122021738 0.79425444183377 GO:0005254 chloride channel activity 1/308 83/18639 0.0120481927710843 0.729111250195588 0.749943390375688 0.806525974199034 GO:0008083 growth factor activity 2/308 162/18639 0.0123456790123457 0.747113997113997 0.751036987174141 0.806525974199034 GO:0004527 exonuclease activity 1/308 84/18639 0.0119047619047619 0.720431354359926 0.754093931212306 0.808419737577515 GO:0046873 metal ion transmembrane transporter activity 6/308 450/18639 0.0133333333333333 0.806883116883117 0.757072883919068 0.810223548714756 GO:0051020 GTPase binding 4/308 315/18639 0.0126984126984127 0.768460111317254 0.767388566671159 0.81985957977688 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/308 88/18639 0.0113636363636364 0.687684474616293 0.770020603680109 0.821267708703188 GO:0072341 modified amino acid binding 1/308 91/18639 0.010989010989011 0.665013557870701 0.781287028075534 0.831864382533575 GO:0051213 dioxygenase activity 1/308 93/18639 0.010752688172043 0.650712191034772 0.788490616168661 0.838106522288117 GO:0004252 serine-type endopeptidase activity 2/308 176/18639 0.0113636363636364 0.687684474616293 0.79067573805609 0.83900226873524 GO:0004867 serine-type endopeptidase inhibitor activity 1/308 95/18639 0.0105263157894737 0.637012987012987 0.795457689963803 0.842645858012503 GO:0003713 transcription coactivator activity 3/308 256/18639 0.01171875 0.709174614448052 0.798142671064538 0.844059508316982 GO:0030594 neurotransmitter receptor activity 1/308 97/18639 0.0103092783505155 0.623878698620967 0.802195990433467 0.846912996656954 GO:0042626 ATPase-coupled transmembrane transporter activity 1/308 98/18639 0.0102040816326531 0.617512589451365 0.805481700440289 0.848947829300473 GO:0003730 mRNA 3'-UTR binding 3/308 262/18639 0.0114503816793893 0.692933974422524 0.81071918760993 0.853029448242771 GO:0005496 steroid binding 1/308 108/18639 0.00925925925925926 0.560335497835498 0.835489950391825 0.87761549410906 GO:0004222 metalloendopeptidase activity 1/308 110/18639 0.00909090909090909 0.550147579693034 0.840913225917679 0.881830144628438 GO:0016829 lyase activity 2/308 200/18639 0.01 0.605162337662338 0.845812383012267 0.884362748610448 GO:0043022 ribosome binding 1/308 112/18639 0.00892857142857143 0.540323515769944 0.846158277870476 0.884362748610448 GO:0031267 small GTPase binding 3/308 283/18639 0.0106007067137809 0.64151484557845 0.849644308301493 0.886523693970673 GO:0022853 active monoatomic ion transmembrane transporter activity 1/308 118/18639 0.00847457627118644 0.512849438696896 0.86088152979755 0.896751593539114 GO:0004518 nuclease activity 2/308 209/18639 0.00956937799043062 0.579102715466352 0.862847029215703 0.897303482961421 GO:0005216 monoatomic ion channel activity 5/308 448/18639 0.0111607142857143 0.67540439471243 0.865979201837431 0.899064785960788 GO:0004540 RNA nuclease activity 1/308 121/18639 0.00826446280991736 0.500134163357304 0.867707637817834 0.899365296245682 GO:0008528 G protein-coupled peptide receptor activity 1/308 122/18639 0.00819672131147541 0.496034703001916 0.869907985995397 0.900153131203846 GO:0022804 active transmembrane transporter activity 5/308 457/18639 0.0109409190371991 0.662103214072579 0.876859275912414 0.90584635941365 GO:0031490 chromatin DNA binding 1/308 128/18639 0.0078125 0.472783076298701 0.882364744158538 0.91002964537803 GO:0140098 catalytic activity, acting on RNA 4/308 387/18639 0.0103359173126615 0.625490788281486 0.885324915277378 0.911578372402572 GO:0005179 hormone activity 1/308 132/18639 0.00757575757575758 0.458456316410862 0.890001320326409 0.914886225664483 GO:0051087 protein-folding chaperone binding 1/308 134/18639 0.00746268656716418 0.45161368482264 0.893632224894644 0.917110247223567 GO:0044325 transmembrane transporter binding 1/308 136/18639 0.00735294117647059 0.44497230710466 0.897143654611749 0.917700137696142 GO:0099094 ligand-gated monoatomic cation channel activity 1/308 136/18639 0.00735294117647059 0.44497230710466 0.897143654611749 0.917700137696142 GO:0020037 heme binding 1/308 142/18639 0.00704225352112676 0.42617066032559 0.906999647465452 0.926265979846254 GO:0046906 tetrapyrrole binding 1/308 152/18639 0.00657894736842105 0.398133116883117 0.921378384841416 0.939415155833418 GO:0005261 monoatomic cation channel activity 3/308 341/18639 0.00879765395894428 0.532400883573904 0.923183681000413 0.939722802321267 GO:0015079 potassium ion transmembrane transporter activity 1/308 160/18639 0.00625 0.378226461038961 0.931267965183088 0.94641053372265 GO:0015081 sodium ion transmembrane transporter activity 1/308 164/18639 0.00609756097560976 0.369001425403864 0.935737404449526 0.949408892501548 GO:0015399 primary active transmembrane transporter activity 1/308 166/18639 0.00602409638554217 0.364555625097794 0.937862267333816 0.950022556051272 GO:0015078 proton transmembrane transporter activity 1/308 185/18639 0.00540540540540541 0.327114777114777 0.954861340326675 0.964802479630772 GO:0015276 ligand-gated monoatomic ion channel activity 1/308 186/18639 0.00537634408602151 0.325356095517386 0.955614711258689 0.964802479630772 GO:0022834 ligand-gated channel activity 1/308 188/18639 0.00531914893617021 0.32189486045869 0.957084059793726 0.964802479630772 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/308 229/18639 0.00436681222707424 0.264263029546872 0.978494608645844 0.984797311439054 GO:0022836 gated channel activity 1/308 318/18639 0.00314465408805031 0.190302621906395 0.995226387477153 0.999093807771662 GO:0030371 translation repressor activity 1/308 329/18639 0.00303951367781155 0.183939920262109 0.996038766162646 0.999093807771662 GO:0045182 translation regulator activity 1/308 356/18639 0.00280898876404494 0.169989420691668 0.997495257679227 0.999093807771662 GO:0004984 olfactory receptor activity 1/308 419/18639 0.00238663484486874 0.144430152186715 0.999142731208887 0.999142731208887