category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/405	78/9376	4.45204178537512	TOB1/CNOT2/LSM2/EXOSC7/DCP2/XRN2/LSM8/CNOT4/C1D/EXOSC3/TENT4B/CNOT8/LSM5/LSM1/LSM3	6.50461050059855
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/405	250/9376	2.68547160493827	USP8/RUFY2/CYTH2/RAB5B/SMAD2/ARFGEF1/TGFBR1/ARPC4/VPS26A/ARPC1B/VPS37A/TSG101/VPS35/WIPF1/CBLB/SMAP1/ZFYVE16/WASHC3/SNX4/CHMP1A/EPS15/ARPC1A/EHD1/IQSEC1/ACTR3/ACAP2/RABEP1/PRKCI/GIT2	5.73910187466543
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/405	46/9376	5.03274288781535	ADRM1/PSME1/PSMD3/PSMA4/PSMA5/PSMB8/PSMB2/PSMD9/PSMD7/PSMC6	5.82547508792293
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/405	32/9376	5.78765432098765	ATG12/IGBP1/GABARAP/ATG3/BECN1/ATG5/PPP2CA/WIPI1	5.76400145286036
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	29/405	308/9376	2.17976591309925	ADRM1/GPX7/EP300/HDAC1/NDUFA10/SDHC/POLR2F/NDUFB8/PPIF/PSMD3/BECN1/PSMA4/DCTN6/PSMA5/NDUFA12/NDUFA8/NDUFV3/DCTN5/POLR2H/GPX8/NDUFS4/WIPI1/PSMB2/PSMD9/HDAC2/NRBF2/DCTN4/PSMD7/PSMC6	4.47309547489478
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	32/405	368/9376	2.01309715512614	ADRM1/GPX7/DAXX/TNFRSF1A/ATF4/NXT1/NDUFA10/SDHC/RANBP2/NDUFB8/PSMD3/BECN1/PSMA4/DCTN6/PSMA5/NDUFA12/NDUFA8/NDUFV3/DCTN5/ATF6/GPX8/NDUFS4/DERL1/WIPI1/PSMB2/PSMD9/NRBF2/DCTN4/ANG/BCL2L1/PSMD7/PSMC6	4.212632149861
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/405	117/9376	2.96802785691675	SMARCD3/BCL7C/BRD8/HDAC1/RUVBL1/BAZ1B/SMARCE1/SS18/SMARCA4/HDAC2/CHRAC1/CDK2AP2/INO80D/BCL7B/SMARCD1	4.55129359357197
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	25/405	268/9376	2.15957250783121	ADRM1/DAXX/ATF4/NDUFA10/MFN1/SDHC/NDUFB8/PPIF/PSMD3/PSMA4/SLC39A10/SLC39A7/PSMA5/NDUFA12/NDUFA8/NDUFV3/UBA1/ATF6/NDUFS4/SNCAIP/PSMB2/PSMD9/BCL2L1/PSMD7/PSMC6	4.09210263368309
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/405	44/9376	4.20920314253648	RAB5B/STX4/NSF/ARHGDIA/DCTN6/DCTN5/DYNC1LI1/DCTN4	4.5334507646516
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	22/405	235/9376	2.16729183083793	SMARCD3/SOS1/PRKAA1/ATF2/NDUFA10/SDHC/NDUFB8/ZNF516/KDM3A/NDUFA12/NDUFA8/NDUFV3/SMARCE1/COX11/NDUFAF8/PRKAG1/NDUFS4/SMARCA4/ACSL1/ACSL4/SMARCD1/COX17	3.85043010540772
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/405	243/9376	2.09594065945232	WBP11/SLU7/LSM2/SNW1/CDC5L/PRPF8/SF3A3/DDX46/SNRPD1/SRSF8/CWC15/LSM8/BCAS2/NCBP2/ZMAT2/SNRPA1/LSM5/SNRPA/LSM3/MAGOH/DHX15/SNRPF	3.67769889284704
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	35/405	480/9376	1.6880658436214	ADRM1/GPX7/DAXX/TNFRSF1A/ATF4/NDUFA10/MFN1/SDHC/NDUFB8/PPIF/PSMD3/BECN1/PSMA4/DCTN6/PSMA5/NDUFA12/NDUFA8/NDUFV3/UBA1/LRP6/DCTN5/ATF6/GPX8/NDUFS4/DERL1/SNCAIP/WIPI1/PSMB2/PSMD9/NRBF2/DCTN4/PSEN1/BCL2L1/PSMD7/PSMC6	3.28810708208845
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/405	105/9376	2.6457848324515	USP8/RAB5B/ATF4/CCZ1/TBC1D15/MFN1/USP15/MTX3/GABARAP/BECN1/OPA1/BCL2L1	3.60327273918013
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/405	33/9376	4.20920314253648	STX7/USE1/STX8/STX4/VAMP4/VAMP3	3.92377165711912
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/405	56/9376	3.30723104056437	GANAB/ALG14/DHRSX/STT3A/B4GALT1/MGAT1/DDOST/DPAGT1	3.67933951524714
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/405	144/9376	2.25075445816187	ADRM1/RBPJ/PPIF/PSMD3/BECN1/PSMA4/PSMA5/OPA1/WIPI1/PSMB2/PSMD9/NRBF2/PSMD7/PSMC6	3.2136466949587
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/405	63/9376	2.93976092494611	RPA2/POLR2F/GTF2H1/POLR2M/ERCC1/PCNA/POLR2H/RFC1	3.2822102791505
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	20/405	250/9376	1.85204938271605	TPP1/BORCS7/RRAGC/BLOC1S2/VPS26A/RRAGA/CTSO/VPS35/VPS13C/AP3M1/ARL8B/SGSH/GNS/CTBS/ATP6AP1/DNASE2/ATP6V0A1/DMXL2/LAMTOR2/M6PR	2.90126407073603
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/405	169/9376	2.05478851632698	ATG12/STX7/RRAGC/IGBP1/PRKAA1/RRAGA/GABARAP/ATG3/BECN1/ATG5/PPP2CA/WIPI1/NRBF2/SUPT20H/BCL2L1	2.93996659013469
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/405	30/9376	3.85843621399177	SUCLA2/SUCLG2/PDHB/SDHC/MDH1	3.33172360559974
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/405	388/9376	1.61099656357388	ADRM1/TNFRSF1A/ATF4/NDUFA10/SDHC/NDUFB8/PPIF/PSMD3/BECN1/PSMA4/SLC39A10/SLC39A7/PSMA5/NDUFA12/NDUFA8/NDUFV3/LRP6/ATF6/NDUFS4/RTN3/WIPI1/PSMB2/PSMD9/NRBF2/PSEN1/PSMD7/PSMC6	2.61165508426512
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/405	32/9376	3.61728395061728	SUCLA2/SUCLG2/ECHDC1/HADHA/ALDH6A1	3.15102709645796
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/405	73/9376	2.53705394892609	CCNT1/BICD2/EP300/TSG101/RANBP2/XPO1/BICD1/CD4	2.80112024304739
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/405	103/9376	2.24763274601462	SMG1/PPP2R1A/RNPS1/NXT1/RNMT/FIP1L1/NCBP2/PAPOLA/PPP2CA/MAGOH	2.70512892938461
Genetic Information Processing	Translation	hsa03010	Ribosome	17/405	222/9376	1.77279501723946	MRPL1/MRPL36/MRPS14/MRPS22/MRPS10/MRPL13/MRPL55/DAP3/MRPL3/MRPL15/MRPL23/RSL24D1/MRPS7/MRPS5/MRPS18A/RPL36A/MRPS28	2.47587131305564
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/405	23/9376	4.02619431025228	RPA2/PCNA/SSBP1/RFC1	3.08729395594713
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/405	138/9376	2.01309715512614	NDUFA10/SDHC/NDUFB8/NDUFA12/NDUFA8/NDUFV3/PPA2/COX11/NDUFS4/ATP6AP1/ATP6V0A1/COX17	2.5473837937179
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/405	62/9376	2.61377937076862	RBPJ/DTX3L/EP300/SNW1/HDAC1/HDAC2/PSEN1	2.70872308439652
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/405	108/9376	2.14357567443987	KPNA1/RNPS1/NXT1/RANBP2/XPO1/AHCTF1/NCBP2/KPNA3/TMEM33/MAGOH	2.53966535964533
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/405	248/9376	1.68028673835125	KPNA1/CYTH2/RAB5B/ARPC4/TNFRSF1A/DYNLT1/ARPC1B/SNX18/KPNA3/DCTN6/ARL8B/DCTN5/DYNC1LI1/RAB9A/ARPC1A/ACTR3/DCTN4/M6PR	2.30686803337906
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/405	83/9376	2.23138479845307	USP7/EP300/FOXK2/HDAC1/AEBP2/UBE2D2/RYBP/HDAC2	2.39412921883633
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/405	170/9376	1.77034132171387	PPP2R1A/PRKAA1/ARPC4/ARPC1B/JAM3/RAB13/CTTN/PCNA/PRKAG1/PPP2CA/ARPC1A/ACTR3/PRKCI	2.1535992498206
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	13/405	174/9376	1.72964382006528	BAG1/ATF4/GANAB/SAR1B/PLAA/UBE2D2/UBXN1/BCAP29/OS9/STT3A/ATF6/DERL1/DDOST	2.06413044519451
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/405	157/9376	1.76947393253126	PRKAA1/TNFRSF1A/ATF4/NDUFA10/ADIPOR1/SDHC/NDUFB8/NDUFA12/NDUFA8/NDUFV3/PRKAG1/NDUFS4	2.06582986703084
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/405	44/9376	2.6307519640853	ALG14/STT3A/B4GALT1/MGAT1/DDOST	2.3036664898366
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/405	44/9376	2.6307519640853	APEX1/PCNA/NEIL2/RFC1/TDG	2.3036664898366
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/405	142/9376	1.79335767692575	KLHL9/UBE3A/UBE2Z/UBE2E3/CBLB/PIAS1/UBE2D2/UBE2R2/UBA1/UBE2S/UBE2Q1	2.02400223202774
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/405	253/9376	1.55557507441565	ATG12/CYTH2/RRAGC/BCL10/ARPC4/TNFRSF1A/ARPC1B/RRAGA/BECN1/CTTN/ATG5/UBE2D2/ARPC1A/WIPI1/ACTR3/TLN2/BCL2L1	1.90338611885273
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/405	93/9376	1.99145094915704	PDCD10/EP300/YES1/TGFBR1/SNAI2/CTNNA1/PTPN1/SORBS1	2.04155579433811
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/405	110/9376	1.89414141414141	PPP2R1A/SMAD2/EP300/TGFBR1/HDAC1/ZFYVE16/PPP2CA/NBL1/HDAC2	2.00423723739388
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/405	275/9376	1.51531313131313	ADRM1/ATF4/ATF2/NDUFA10/SDHC/NDUFB8/PPIF/PSMD3/PSMA4/PSMA5/NDUFA12/NDUFA8/NDUFV3/NDUFS4/PSMB2/PSMD9/PSMD7/PSMC6	1.84283189644673
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/405	34/9376	2.72360203340595	PRKAA1/CSNK1D/CLOCK/PRKAG1	2.13918944116339
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/405	83/9376	1.95246169864644	GSTK1/PMVK/GNPAT/MPV17/PEX1/ACSL1/ACSL4	1.85183086994136
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/405	36/9376	2.57229080932785	GALNT1/C1GALT1/ST3GAL1/C1GALT1C1	2.00818356988919
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/405	36/9376	2.57229080932785	RPA2/PCNA/SSBP1/RFC1	2.00818356988919
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/405	23/9376	3.01964573268921	PMVK/NUS1/FNTA	2.06042290231059
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/405	138/9376	1.67758096260512	ARHGEF12/ARPC4/ARPC1B/WIPF1/NFATC3/ARPC1A/LIMK1/CD4/ACTR3/GIT2	1.70374455632257
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/405	157/9376	1.62201777148699	PPP2R1A/SMAD2/TGFBR1/MOB1A/SNAI2/CSNK1D/SAV1/CTNNA1/STK3/PPP2CA/PRKCI	1.66994986553308
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/405	70/9376	1.98433862433862	PRKAA1/TNFRSF1A/ADIPOR1/PRKAG1/ACSL1/ACSL4	1.75632443709289
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/405	54/9376	2.14357567443987	CENPX/RPA2/REV1/ERCC1/POLK	1.79060569231152
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/405	90/9376	1.80060356652949	PRKAA1/ATF4/ATF2/ADIPOR1/EIF4E/ATG5/PRKAG1	1.62150076160261
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/405	205/9376	1.4680879253237	RBPJ/USP7/EP300/SNW1/ATF4/ATF2/UBE3A/HDAC1/GTF2H1/GTF2A1/RASA2/GTF2A2/HDAC2	1.43975549120342
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/405	59/9376	1.96191671897887	GPX7/ANPEP/GSTK1/GPX8/GGT7	1.57477369879382
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/405	77/9376	1.8039442039442	SMAD2/TGFBR1/RALBP1/POLK/RALB/BCL2L1	1.50503246679588
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/405	77/9376	1.8039442039442	SOS1/TGFBR1/HDAC1/POLK/HDAC2/BCL2L1	1.50503246679588
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/405	78/9376	1.78081671415005	ARPC4/ARPC1B/CTTN/CTNNA1/ARPC1A/ACTR3	1.47127668599508
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/405	14/9376	3.30723104056437	ST3GAL1/B4GALT1	1.83553853657132
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/405	44/9376	2.10460157126824	GTF2H1/GTF2A1/TAF12/GTF2A2	1.56040506489827
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/405	133/9376	1.56658312447786	SOS1/ATG12/USP7/EP300/PRKAA1/TGFBR1/GABARAP/HOMER1/PRKAG1	1.39822061340801
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/405	29/9376	2.39489144316731	MOB1A/SAV1/STK3	1.59843878630189
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/405	116/9376	1.59659429544487	SUCLA2/SUCLG2/PDHB/GLUD1/SDHC/MDH1/H6PD/ALDH6A1	1.37371082047764
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/405	62/9376	1.86698526483473	PRKAA1/HDAC1/ATG5/PRKAG1/HDAC2	1.45523176416051
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/405	138/9376	1.50982286634461	SOS1/PRKAA1/CBLB/EIF4E/PRKAG1/PTPN1/PRKCI/SORBS1/SOCS2	1.28192493762491
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/405	122/9376	1.51807326452135	SOS1/PPP2R1A/BCL10/CBLB/NFATC3/PPP2CA/NCK1/CD4	1.22376793607159
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/405	32/9376	2.17037037037037	TNFRSF1A/BECN1/BCL2L1	1.40904419218969
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/405	49/9376	1.88984630889393	GALNT1/C1GALT1/B4GALT1/C1GALT1C1	1.32688955802876
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/405	17/9376	2.72360203340595	GLUD1/CA12	1.51126093498806
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/405	183/9376	1.39156715914457	EIF6/NXT1/IMP4/XRN2/XPO1/NOP58/GNL3/AK6/WDR43/EMG1/UTP14C	1.13656923571317
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/405	205/9376	1.35515808491418	ADRM1/RBPJ/USP7/HLA-DPB1/SNW1/HDAC1/PSMD3/TAPBP/POLK/HDAC2/PSMD7/PSMC6	1.09240331855789
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/405	107/9376	1.5145263643706	PPP4R3B/PDHB/EP300/PRKAA1/ATF4/ATF2/PRKAG1	1.13730199819195
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/405	34/9376	2.04270152505447	POLR2F/POLR2M/POLR2H	1.29411317081924
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/405	18/9376	2.57229080932785	ACSL1/ACSL4	1.41863388614977
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/405	19/9376	2.43690708252112	SGSH/GNS	1.33207872657595
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/405	170/9376	1.36180101670298	SMARCD3/SOS1/SMAD2/TGFBR1/SMARCE1/LRP6/POLK/SMARCA4/SMARCD1/BCL2L1	1.01146644505885
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/405	20/9376	2.31506172839506	FDFT1/SC5D	1.25086013464318
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/405	158/9376	1.31870604781997	SOS1/LPIN1/RRAGC/PRKAA1/TNFRSF1A/RRAGA/EIF4E/LRP6/LAMTOR2	0.858406935490135
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	11/405	200/9376	1.27328395061728	CYTH2/ARHGEF12/ARPC4/TNFRSF1A/ARPC1B/WIPF1/CTTN/MYO1E/ARPC1A/NCK1/ACTR3	0.830032588984571
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/405	23/9376	2.01309715512614	GLUD1/MDH1	1.03355184867406
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/405	224/9376	1.24021164021164	SMAD2/EP300/HLA-DPB1/TGFBR1/TNFRSF1A/ATF4/ATF2/XPO1/NFATC3/CD4/TLN2/BCL2L1	0.773130441376272
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/405	42/9376	1.65361552028219	ATG5/ACSL1/ACSL4	0.901998519027944
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/405	205/9376	1.24222824450467	PDHB/SMAD2/TGFBR1/NDUFA10/SDHC/NDUFB8/PPIF/NDUFA12/NDUFA8/NDUFV3/NDUFS4	0.74505114591236
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/405	227/9376	1.2238211780062	SOS1/PRKD3/NDUFA10/SDHC/NDUFB8/PPIF/NDUFA12/NDUFA8/NDUFV3/ARNT/NDUFS4/PTPN1	0.72530390124407
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/405	24/9376	1.92921810699588	B3GAT3/EXT2	0.968420016147997
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/405	82/9376	1.41162300511894	HLA-DPB1/PSME1/TAPBP/HSPA2/CD4	0.795422648190746
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/405	43/9376	1.6151593453919	HADHA/ACSL1/ACSL4	0.859021319542618
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/405	104/9376	1.33561253561254	GPCPD1/LPIN1/GNPAT/PISD/LYPLA1/ETNK1	0.731241538346817
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/405	300/9376	1.15753086419753	SOS1/GNG12/MAP3K2/DAXX/TGFBR1/TNFRSF1A/ATF4/PPM1B/ATF2/TAOK3/VEGFB/STK3/NFATC3/RASA2/FGF2	0.589212240880316
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/405	46/9376	1.50982286634461	BLVRB/MMAB/HMOX2	0.736461631639718
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/405	87/9376	1.33049524620406	SOS1/SMAD2/TGFBR1/POLK/RALB	0.658010893306886
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/405	130/9376	1.24657169990503	SOS1/GNG12/SMAD2/TGFBR1/ATF4/ATF2/VEGFB	0.601493145191879
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/405	47/9376	1.47769897557132	PDHB/ACYP2/MDH1	0.697554932215485
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/405	69/9376	1.34206477008409	ATF4/ATF2/HDAC1/HDAC2	0.605927631360408
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/405	155/9376	1.19487056949423	STX7/RAB5B/HLA-DPB1/DYNC1LI1/VAMP3/ATP6AP1/ATP6V0A1/M6PR	0.519775510812668
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/405	10/9376	2.31506172839506	TST	0.88401937522575
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/405	30/9376	1.54337448559671	PIGT/PIGP	0.63334406116238
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/405	158/9376	1.17218315361775	PPP2R1A/SMAD2/EP300/HDAC1/PDS5A/PCNA/PPP2CA/HDAC2	0.463760302796426
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/405	31/9376	1.49358821186778	H6PD/PGM2	0.584855656548305
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/405	31/9376	1.49358821186778	HADHA/ALDH6A1	0.584855656548305
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/405	31/9376	1.49358821186778	HYI/MDH1	0.584855656548305
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/405	31/9376	1.49358821186778	SRPRA/SGTA	0.584855656548305
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/405	32/9376	1.44691358024691	B4GALT1/PGM2	0.538052740055557
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/405	163/9376	1.13622661516322	SOS1/EP300/TGFBR1/ATF4/ATF2/NFATC3/PCNA/ATP6AP1	0.372776008562105
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/405	75/9376	1.23469958847737	GPX7/ATF4/ATF2/GPX8	0.433581615390455
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/405	54/9376	1.28614540466392	ADI1/TST/MDH1	0.44804519881989
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/405	98/9376	1.18115394305871	ARPC4/ARPC1B/ARPC1A/LIMK1/ACTR3	0.383024334529372
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/405	122/9376	1.13855494839101	PPP2R1A/PRKAA1/ADIPOR1/RAB14/PRKAG1/PPP2CA	0.327287885395191
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/405	56/9376	1.24021164021164	CSNK1D/MOSMO/PTCH1	0.383065312625486
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/405	168/9376	1.10241034685479	SOS1/EP300/PIAS1/IL13RA1/OSMR/PTPN2/BCL2L1/SOCS2	0.284582731861827
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/405	57/9376	1.21845354126056	HADHA/ACSL1/ACSL4	0.351483208924245
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/405	80/9376	1.15753086419753	SOS1/EIF4E/FGF2/BCL2L1	0.300645918921858
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/405	103/9376	1.12381637300731	PPP2R1A/SMAD2/TGFBR1/TNFRSF1A/PPP2CA	0.268459812090912
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/405	149/9376	1.08761289253459	GNG12/NDUFA10/NDUFB8/NDUFA12/NDUFA8/NDUFV3/NDUFS4	0.229046475911733
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/405	59/9376	1.17715003138732	SOS1/CTNNA1/POLK	0.290015969849652
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/405	150/9376	1.0803621399177	SOS1/SMAD2/TGFBR1/CTNNA1/LRP6/POLK/FGF2	0.2108060732876
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/405	128/9376	1.08518518518519	DGUOK/NT5E/AK6/PDE4B/ITPA/PGM2	0.206175885088528
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/405	37/9376	1.25138471805138	POLK/CCDC6	0.325523441803058
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/405	15/9376	1.54337448559671	ST3GAL1	0.447482927292183
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/405	38/9376	1.21845354126056	NT5E/NNT	0.286692726088711
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/405	85/9376	1.08944081336238	DGUOK/NT5E/AK6/ITPA	0.175997579205124
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/405	16/9376	1.44691358024691	ST3GAL1	0.380135421923899
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/405	109/9376	1.06195492128214	SMAD2/HLA-DPB1/TGFBR1/NFATC3/CD4	0.138233148022339
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/405	63/9376	1.10241034685479	ASH1L/PRDM2/HADHA	0.173285423381493
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/405	133/9376	1.04438874965191	PPP2R1A/GNG12/ATF4/ATF2/CLOCK/PPP2CA	0.109543087475296
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/405	180/9376	1.02891632373114	DAXX/HLA-DPB1/TNFRSF1A/EIF2B3/SRSF8/TAPBP/HCFC2/BCL2L1	0.0832285964698155
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/405	181/9376	1.02323170315804	RAB5B/EP300/BCL10/HLA-DPB1/ARHGEF12/TNFRSF1A/ATP6AP1/ATP6V0A1	0.067055930288376
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/405	17/9376	1.36180101670298	GGT7	0.317228531984095
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/405	41/9376	1.12929840409515	RPA2/SSBP1	0.176287148586889
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/405	137/9376	1.01389564747229	DAXX/TNFRSF1A/ATF4/CTSO/NOL3/BCL2L1	0.0348112252311885
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/405	18/9376	1.28614540466392	MMAB	0.258180970730102
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/405	115/9376	1.00654857756307	OXSR1/ATF4/ATF2/PDE4B/LRP6	0.0150127300458527
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/405	140/9376	0.992169312169312	GNG12/SMAD2/PRKAA1/TGFBR1/BECN1/PRKAG1	-0.0198342000109315
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/405	19/9376	1.21845354126056	PDHB	0.202516445633912
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/405	93/9376	0.995725474578521	RBPJ/HLA-DPB1/NFATC3/CD4	-0.0088019302918468
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/405	238/9376	0.972715011930698	SOS1/GNG12/RAB5B/RALGAPA1/VEGFB/RALBP1/RASA2/FGF2/RALB/BCL2L1	-0.0905898188801335
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/405	20/9376	1.15753086419753	CYB5R1	0.149840173845728
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/405	70/9376	0.992169312169312	SOS1/EP300/ARNT	-0.013972049918821
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/405	120/9376	0.964609053497942	SOS1/ATF4/KIDINS220/ARHGDIA/PSEN1	-0.0829017787966741
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/405	71/9376	0.978195096504956	JAM3/ATP6AP1/ATP6V0A1	-0.0391848217924245
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/405	194/9376	0.954664630266005	TUBE1/DYNLT1/DCTN6/MYO1E/DCTN5/DYNC1LI1/KIF1B/DCTN4	-0.135569534303018
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/405	21/9376	1.10241034685479	B3GAT3	0.0998215501830739
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/405	21/9376	1.10241034685479	PPCS	0.0998215501830739
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/405	122/9376	0.948795790325845	EP300/HDAC1/NCOA1/MED13L/HDAC2	-0.120952139943008
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/405	122/9376	0.948795790325845	SOS1/EP300/ATF4/ATF2/SOCS2	-0.120952139943008
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/405	48/9376	0.964609053497942	HADHA/ALDH6A1	-0.0522289444843892
NA	NA	hsa03272	Virion - Hepatitis viruses	2/405	48/9376	0.964609053497942	TSG101/CHMP1A	-0.0522289444843892
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/405	49/9376	0.944923154446964	ATF4/ATF2	-0.08212754328815
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/405	75/9376	0.926024691358025	CCNG1/AIFM2/BCL2L1	-0.136661227350589
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/405	23/9376	1.00654857756307	GLUD1	0.0066807950375244
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/405	23/9376	1.00654857756307	B4GALT1	0.0066807950375244
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/405	23/9376	1.00654857756307	ANPEP	0.0066807950375244
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/405	76/9376	0.913840155945419	ACSL1/ACSL4/SORBS1	-0.160237052460844
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/405	51/9376	0.907867344468652	ATP6AP1/ATP6V0A1	-0.140173842402732
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/405	178/9376	0.910417533638507	CACYBP/EP300/RUVBL1/LRP6/NFATC3/ROR2/PSEN1	-0.256376984554827
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/405	78/9376	0.890408357075024	INPP4B/PPIP5K2/ALDH6A1	-0.206501252206072
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/405	105/9376	0.881928277483833	BCL10/ARHGEF12/CBLB/NFATC3	-0.258505614234407
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	9/405	232/9376	0.898084291187739	SOS1/GNG12/ARHGEF12/ARPC4/ARPC1B/ARPC1A/FGF2/LIMK1/ACTR3	-0.333971751728185
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/405	157/9376	0.884736966265629	RAB5B/PROS1/SLC16A1/RAB14/NFATC3/ARNT	-0.309450141955751
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/405	26/9376	0.890408357075024	BTD	-0.118891560573937
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	13/405	333/9376	0.903777851926	SOS1/PPP2R1A/RBPJ/EP300/TNFRSF1A/UBE3A/HDAC1/PPP2CA/ATP6AP1/ATP6V0A1/HDAC2/PRKCI/PSEN1	-0.379868796391174
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/405	55/9376	0.841840628507295	KDSR/CERS6	-0.249941137905757
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/405	27/9376	0.857430269775949	HADHA	-0.157622913767079
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/405	109/9376	0.849563937025711	PRKAA1/TNFRSF1A/PRKAG1/PTPN1	-0.335651311157717
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/405	83/9376	0.836769299419902	POLR2F/POLR2H/DNASE2	-0.317362525638513
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/405	187/9376	0.866600646992804	ATG12/MFN1/GABARAP/ATG5/TRPM7/ERBIN/BCL2L1	-0.391501222220931
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/405	110/9376	0.841840628507295	PDHB/EP300/EIF4E/ARNT	-0.354517637562818
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/405	28/9376	0.826807760141093	HADHA	-0.195002785107822
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/405	28/9376	0.826807760141093	B4GALT1	-0.195002785107822
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/405	28/9376	0.826807760141093	QDPR	-0.195002785107822
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/405	28/9376	0.826807760141093	ATP6V0A1	-0.195002785107822
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/405	112/9376	0.826807760141093	HLA-DPB1/TNFRSF1A/PPIF/BCL2L1	-0.391769740118858
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/405	86/9376	0.807579672695952	SOS1/CBLB/NCK1	-0.380877255559557
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/405	60/9376	0.771687242798354	PPP2R1A/PPP2CA	-0.376950032882246
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/405	88/9376	0.789225589225589	PLAUR/PROS1/PROCR	-0.422076174917212
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/405	89/9376	0.780357885975864	SOS1/MAP3K2/CSNK1D	-0.442349577802118
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/405	89/9376	0.780357885975864	GNG12/NSF/GABARAP	-0.442349577802118
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/405	61/9376	0.759036632260676	TRPM7/HMOX2	-0.401159640720228
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	7/405	196/9376	0.826807760141093	GNG12/EP300/TNFRSF1A/ATG3/BECN1/NFATC3/FGF2	-0.520628388600166
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/405	144/9376	0.803840877914952	LPIN1/PRKAA1/TNFRSF1A/ADIPOR1/PRKAG1	-0.504004691137413
Human Diseases	Immune disease	hsa05310	Asthma	1/405	32/9376	0.723456790123457	HLA-DPB1	-0.332938712078577
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/405	91/9376	0.763207163207163	SOS1/BCL10/NFATC3	-0.482270862728127
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/405	63/9376	0.734940231236527	POLK/PTCH1	-0.448499547772307
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/405	173/9376	0.802911582102333	KPNA1/EP300/HLA-DPB1/TNFRSF1A/NXT1/XPO1	-0.555919829265594
NA	NA	hsa04519	Cadherin signaling	15/405	404/9376	0.85955262192886	EP300/MOB1A/ARPC4/ARPC1B/RERE/TAOK3/SAV1/CTNNA1/STK3/MYO1E/LRP6/ARPC1A/ERBIN/ACTR3/PSEN1	-0.613129775864448
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/405	33/9376	0.701533857089413	PDHB	-0.364923297201002
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/405	227/9376	0.815880785337467	SOS1/GNG12/ARHGEF12/TNFRSF1A/ATF4/ATF2/TAPBP/NFATC3	-0.596647671495279
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/405	201/9376	0.806240402923653	CCNT1/KDM6A/HDAC1/SS18/POLK/HDAC2/BCL2L1	-0.589998539259345
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/405	93/9376	0.746794105933891	SOS1/MAP3K2/ATF4	-0.521391361449336
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/405	93/9376	0.746794105933891	POLK/CKS1B/BCL2L1	-0.521391361449336
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/405	148/9376	0.782115448782115	SOS1/NCOA1/LRP6/POLK/FGF2	-0.567670367510887
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/405	65/9376	0.712326685660019	ATF4/ATF2	-0.494482371501728
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/405	204/9376	0.79438392641007	SOS1/SMAD2/ARHGEF12/PLAUR/CTTN/FGF2/PTCH1	-0.630859785327096
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/405	95/9376	0.731072124756335	HLA-DPB1/ATP6AP1/ATP6V0A1	-0.559748525674542
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/405	66/9376	0.701533857089413	SMAD2/HLA-DPB1	-0.516993308448551
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/405	67/9376	0.691063202505989	PDHB/PGM2	-0.539197969298205
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/405	67/9376	0.691063202505989	EP300/ATF4	-0.539197969298205
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/405	125/9376	0.74081975308642	PPP2R1A/TNFRSF1A/CERS6/PPP2CA	-0.619805301657868
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/405	36/9376	0.643072702331962	PGM2	-0.455879746017421
Organismal Systems	Immune system	hsa04611	Platelet activation	4/405	126/9376	0.734940231236527	ARHGEF12/APBB1IP/PRKCI/TLN2	-0.63643043847398
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/405	154/9376	0.751643418310085	PPP2R1A/ATF4/ATF2/CREM/PPP2CA	-0.660261838198518
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/405	98/9376	0.708692365835223	PRKD3/ATF4/ATF2	-0.615928700393407
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/405	37/9376	0.625692359025692	GLUD1	-0.484698960730915
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/405	37/9376	0.625692359025692	PGM2	-0.484698960730915
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/405	99/9376	0.701533857089413	SOS1/GPCPD1/LYPLA1	-0.634310081078683
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/405	156/9376	0.742006964229186	SOS1/PPP2R1A/TNFRSF1A/PIAS1/PPP2CA	-0.690394849769202
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/405	70/9376	0.661446208112875	HLA-DPB1/EIF4G1	-0.604070878922726
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/405	100/9376	0.694518518518518	ANPEP/HLA-DPB1/CD4	-0.652525126624192
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/405	38/9376	0.609226770630279	PGM2	-0.512840587357974
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/405	38/9376	0.609226770630279	CD4	-0.512840587357974
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/405	212/9376	0.764407174470067	PRKD3/VEGFB/APBB1IP/FGF2/RALB/PRKCI/TLN2	-0.737191251220362
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/405	71/9376	0.652130064336637	SOS1/SOCS2	-0.625144772551233
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/405	101/9376	0.687642097543088	SMAD2/TGFBR1/VEGFB	-0.670577453109942
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/405	39/9376	0.593605571383349	HLA-DPB1	-0.540342454240199
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/405	214/9376	0.7572631821853	GNG12/TNFRSF1A/TAPBP/NFATC3/LIMK1/CD4/BCL2L1	-0.763203087531391
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/405	72/9376	0.643072702331962	ATG12/ATG5	-0.645957407310854
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/405	73/9376	0.634263487231524	POLK/FGF2	-0.666516585350251
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/405	73/9376	0.634263487231524	SOS1/POLK	-0.666516585350251
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/405	217/9376	0.746794105933891	SOS1/KPNA1/ATF4/ATF2/KPNA3/ARNT/FGF2	-0.801811664153693
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/405	105/9376	0.661446208112875	BCL10/TNFRSF1A/BCL2L1	-0.741227908411224
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/405	191/9376	0.72724452200892	SOS1/GNG12/ATF4/ATF2/HDAC1/HDAC2	-0.809176583630836
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/405	75/9376	0.617349794238683	ERCC1/BCL2L1	-0.706904070091634
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/405	106/9376	0.655206149545772	SOS1/EP300/ATF4	-0.758516964574202
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/405	42/9376	0.551205173427396	HADHA	-0.619343109755291
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/405	76/9376	0.609226770630279	SOS1/POLK	-0.726746329939301
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/405	139/9376	0.666204813926637	SOS1/ATF4/ATF2/NCOA1	-0.842392940866065
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/405	44/9376	0.526150392817059	HLA-DPB1	-0.669379209916732
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/405	79/9376	0.586091576808876	NSF/ATP6V0A1	-0.784944798975996
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/405	45/9376	0.514458161865569	HLA-DPB1	-0.693683783177887
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/405	362/9376	0.767423777368529	SOS1/PPP2R1A/GNG12/PRKAA1/ATF4/ATF2/VEGFB/EIF4E/PPP2CA/FGF2/OSMR/BCL2L1	-0.958856336423911
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/405	47/9376	0.492566325190439	SOCS2	-0.740974715745009
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/405	50/9376	0.463012345679012	ALDH18A1	-0.808899038503434
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/405	50/9376	0.463012345679012	HLA-DPB1	-0.808899038503434
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/405	86/9376	0.538386448463968	ATF4/ATF2	-0.913718966709424
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/405	119/9376	0.583629007158419	TNFRSF1A/ATF4/ATF2	-0.971206401647482
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/405	184/9376	0.629092860976919	ARHGEF12/NFATC3/NCK1/LIMK1/PTCH1	-1.07959736927441
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/405	90/9376	0.514458161865569	NFATC3/CD4	-0.983391147928278
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/405	155/9376	0.597435284747113	USP8/ATF4/ATF2/ARNT	-1.07375516502468
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/405	54/9376	0.428715134887974	HLA-DPB1	-0.894515294671734
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/405	91/9376	0.508804775471442	GNG12/PDE4B	-1.00040671799786
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/405	216/9376	0.643072702331962	TNFRSF1A/ATF4/HSPA2/NFATC3/ATF6/BCL2L1	-1.12759106043713
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/405	157/9376	0.589824644177086	SMAD2/TGFBR1/NFATC3/TRPM7	-1.10121014495128
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/405	56/9376	0.413403880070547	SAR1B	-0.935444368423176
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/405	94/9376	0.492566325190439	MAPK6/USP25	-1.05054618781011
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/405	59/9376	0.392383343795773	NT5E	-0.994741759094517
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/405	98/9376	0.472461577223482	INPP4B/PPIP5K2	-1.1154052178548
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/405	99/9376	0.467689238059608	PRKAA1/PRKAG1	-1.13128437039043
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/405	166/9376	0.557846199613268	ATF4/ATF2/PPIF/NFATC3	-1.22120988945649
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/405	168/9376	0.551205173427396	GLUD1/TNFRSF1A/TRPM7/CHMP1A	-1.24713236224637
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/405	136/9376	0.510675381263617	CBLB/RAB9A/BCL2L1	-1.22130252906087
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/405	65/9376	0.356163342830009	LPIN1	-1.10669242236667
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/405	142/9376	0.489097548252478	TGFBR1/TNFRSF1A/FHL2	-1.30340668876165
NA	NA	hsa04517	IgSF CAM signaling	8/405	299/9376	0.619414509269582	ARPC4/ARPC1B/JAM3/ARPC1A/NCK1/ACTR3/PRKCI/SORBS1	-1.42105005357117
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/405	68/9376	0.340450254175744	SOS1	-1.15975578583945
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/405	69/9376	0.335516192521023	SOS1	-1.1770551508245
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/405	70/9376	0.330723104056437	GSTK1	-1.19416970792663
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/405	71/9376	0.326065032168319	PDHB	-1.21110472331004
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/405	149/9376	0.466119811086254	SOS1/CYTH2/RALB	-1.39572353214456
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/405	73/9376	0.317131743615762	GSTK1	-1.24445605674986
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/405	115/9376	0.402619431025228	GNG12/ATF4	-1.36950553464182
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/405	116/9376	0.399148573861218	JAM3/CTNNA1	-1.38351323820618
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/405	116/9376	0.399148573861218	GNG12/HOMER1	-1.38351323820618
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/405	75/9376	0.308674897119342	ALDH18A1	-1.27714691283268
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/405	154/9376	0.450986050986051	PPCS/AK6/MMAB	-1.45956655026428
NA	NA	hsa04518	Integrin signaling	3/405	154/9376	0.450986050986051	VEGFB/PARVA/TLN2	-1.45956655026428
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/405	154/9376	0.450986050986051	PRKAA1/NFATC3/PRKAG1	-1.45956655026428
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/405	78/9376	0.296802785691675	HLA-DPB1	-1.32501987767351
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/405	79/9376	0.293045788404438	GSTK1	-1.34068310866405
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/405	160/9376	0.434074074074074	HLA-DPB1/JAM3/CD4	-1.53405549212062
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/405	82/9376	0.282324601023788	ITPA	-1.38684004367068
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/405	298/9376	0.543806446267296	TGFBR1/TNFRSF1A/TNFRSF12A/TNFSF12/IL13RA1/OSMR/CD4	-1.70041492592111
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/405	86/9376	0.269193224231984	CTNNA1	-1.44656067785929
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/405	203/9376	0.456169798698534	SOS1/VEGFB/PARVA/TLN2	-1.66436420084355
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/405	138/9376	0.335516192521023	PPP2R1A/PPP2CA	-1.67081239325872
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/405	142/9376	0.326065032168319	PRKAA1/TNFRSF1A	-1.71933280386033
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/405	97/9376	0.238666157566501	GNG12	-1.60141221381638
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/405	143/9376	0.32378485711819	HLA-DPB1/SNRPD1	-1.73130751586983
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/405	144/9376	0.321536351165981	SMAD2/FGF2	-1.74322181983612
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/405	99/9376	0.233844619029804	SOS1	-1.62825865970219
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/405	99/9376	0.233844619029804	HLA-DPB1	-1.62825865970219
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/405	100/9376	0.231506172839506	TNFRSF1A	-1.64154478185025
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/405	101/9376	0.229214032514363	EP300	-1.65474184230284
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/405	103/9376	0.224763274601462	COL18A1	-1.68087548174404
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/405	103/9376	0.224763274601462	RAB5B	-1.68087548174404
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/405	195/9376	0.356163342830009	HDAC1/PPIF/HDAC2	-1.93037077220889
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/405	115/9376	0.201309715512614	GNG12	-1.83101162287105
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/405	254/9376	0.364576650140955	VEGFB/PPIF/NFATC3/FGF2	-2.18136186076852
NA	NA	hsa04382	Cornified envelope formation	3/405	217/9376	0.32005461682881	PPP2R1A/KDSR/PPP2CA	-2.15314158157697
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/405	133/9376	0.174064791608651	SOS1	-2.03825278907922
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/405	226/9376	0.307309078990495	EP300/PDE4B/PTCH1	-2.23962800523527
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/405	134/9376	0.172765800626497	ARHGEF12	-2.04922959440029
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/405	193/9376	0.239902769781872	SOS1/GNG12	-2.26698284550833
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/405	238/9376	0.291814503579209	TNFRSF1A/RSL24D1/RPL36A	-2.35127080471318
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/405	323/9376	0.358368688606047	SOS1/EP300/HDAC1/CCNG1/HDAC2	-2.49335014637448
NA	NA	hsa04081	Hormone signaling	2/405	219/9376	0.211421162410508	GNG12/ADIPOR1	-2.50889964413097
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	2/405	233/9376	0.198717744926615	FHL2/TLN2	-2.63155133966108
NA	NA	hsa04082	Neuroactive ligand signaling	1/405	199/9376	0.116334760220857	GNG12	-2.67705112719923
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/405	370/9376	0.0625692359025692	PGRMC1	-3.9090102934908