category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/130	78/9376	7.39723865877712	PFKP/DCP2/MTREX/TOB2/PATL1/TOB1/HSPD1/BTG2	6.72706235448776
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/130	142/9376	5.07908992416035	GSTT2B/DUSP1/HSP90AB1/SDC4/JUN/CAV1/FOS/HSP90AA1/CTNNB1/PIK3R1	5.8075490486615
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/130	174/9376	4.55950486295314	DNAJB1/HSPA1B/DNAJA1/HSP90AB1/DDIT3/HSPH1/XBP1/HSP90AA1/UBQLN1/HERPUD1/HSPA5	5.61957497810123
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/130	94/9376	6.13813420621931	FOSB/HSP90AB1/JUN/FOSL1/FOS/MAPK6/HSP90AA1/JUND	5.93647930630686
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/130	204/9376	3.53544494720965	SDC4/CAV1/PPP1CB/MDM2/CTNNB1/EZR/SOS1/LUM/PDCD4/PIK3R1	4.34127818111106
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/130	248/9376	3.19900744416873	RHOB/HSP90AB1/JUN/DYNC1I2/FOS/HSP90AA1/CTNNB1/CYTH3/KPNA4/ACTR3C/PIK3C2A	4.16145395866398
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/130	139/9376	4.15096845600443	KRT19/HSPA1B/HSP90AB1/JUN/FOS/HSP90AA1/SOS1/PIK3R1	4.43778597847389
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/130	110/9376	4.58965034965035	ALDOA/PFKP/SERPINE1/TFRC/LDHA/PIK3R1/EGLN3	4.49037604715408
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/130	216/9376	3.33903133903134	HSPA1B/HSP90AB1/DDIT3/JUN/XBP1/FOS/HSP90AA1/HSPA5/HSPD1/PIK3R1	4.12378058104715
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/130	217/9376	2.99127968805388	GSTT2B/KLF4/HSP90AB1/JUN/FOS/HSP90AA1/SOS1/KPNA4/PIK3R1	3.51899355139692
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/130	106/9376	4.08243831640058	HSP90AB1/MDM2/HSP90AA1/CTNNB1/SOS1/PIK3R1	3.78431979903334
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/130	156/9376	3.23629191321499	IFIT1/OAS1/OAS3/YWHAG/CTNNB1/SOS1/PIK3R1	3.33968650572309
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/130	157/9376	3.215678588927	PPP1CB/YWHAG/CTNNB1/SERPINE1/PARD6B/YAP1/MOB1A	3.31967103745591
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/130	87/9376	4.14500442086649	JUN/FOS/CTNNB1/SOS1/PIK3R1	3.49443345802849
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/130	203/9376	2.84228874573702	JUN/CAV1/PPP1CB/LAMC2/CTNNB1/ACTN4/SOS1/PIK3R1	3.14651923570084
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/130	205/9376	2.81455909943715	JUN/OAS1/OAS3/ISG15/MDM2/HES1/SKP2/PIK3R1	3.11472759958494
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/130	250/9376	2.59643076923077	HSPA1B/CAV1/MDM2/PARD6B/CYTH3/ASAP2/SMURF1/TFRC/ACTR3C	3.033613383134
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/130	91/9376	3.96280642434489	JUN/FOS/SOS1/DAPP1/PIK3R1	3.36754485851693
NA	NA	hsa04519	Cadherin signaling	12/130	404/9376	2.14226961157654	KRT19/PPP1CB/KRT8/YWHAG/CTNNB1/DSP/ACTN4/LIMA1/ACTR3C/FMN1/YAP1/MOB1A	2.78288361056741
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/130	133/9376	3.25367264314633	MDM2/SKP2/SOS1/PLK2/PLK3/PIK3R1	3.10377725830672
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/130	136/9376	3.18190045248869	HSPA1B/JUN/OAS1/OAS3/FOS/PIK3R1	3.03912645304379
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/130	99/9376	3.64257964257964	JUN/MDM2/FOS/SOS1/PIK3R1	3.13416801226028
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/130	142/9376	3.04745395449621	FOSB/JUN/FOSL1/FOS/JUND/PIK3R1	2.91503484519535
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/130	69/9376	4.18104793756968	FOSB/JUN/PPP1CB/FOS	3.14463520445526
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/130	70/9376	4.12131868131868	JUN/SOS1/PIK3R1/EGLN3	3.108035547913
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/130	71/9376	4.06327193932828	PFKP/SLC7A5/LDHA/PIK3R1	3.07211103330298
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/130	148/9376	2.92390852390852	JUN/FOS/HES1/CTNNB1/SOS1/PIK3R1	2.79731808664801
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/130	333/9376	2.16585816585817	HES2/LAMC2/ISG15/MDM2/HES1/ATP6V0C/CTNNB1/PARD6B/SOS1/PIK3R1	2.5685731595403
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	8/130	238/9376	2.42430510665805	JUN/OAS1/OAS3/ISG15/FOS/RPS17/RPL36A/PIK3R1	2.63904200518871
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/130	109/9376	3.30839802399435	HSP90AB1/JUN/FOS/GATA3/HSP90AA1	2.87431744762635
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/130	75/9376	3.8465641025641	GSTT2B/MDM2/TOP2B/PIK3R1	2.93472321519458
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/130	115/9376	3.13578595317726	EGR1/GCM1/FOS/GATA3/JUND	2.73248680695059
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/130	157/9376	2.756295933366	ZFP36L1/PPP1CB/MDM2/SERPINE1/RAD50/PIK3R1	2.63139463112301
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/130	78/9376	3.69861932938856	CAV1/CTNNB1/ACTR3C/PIK3R1	2.8377525785935
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/130	300/9376	2.16369230769231	HSPA1B/DUSP1/DDIT3/JUN/DUSP6/FOS/JUND/SOS1/EPHA2	2.42902462198893
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/130	205/9376	2.4627392120075	GTF2H2/JUN/MDM2/YWHAG/SKP2/ACTN4/PIK3R1	2.51082160732496
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/130	82/9376	3.51819887429644	HSPA1B/HSP90AB1/HSP90AA1/HSPA5	2.7156637013791
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/130	49/9376	4.41569858712716	FOSB/JUN/CDK5R1	2.84241156505283
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/130	93/9376	3.10206782464847	CTNNB1/ACTN4/SMURF1/SNAI1	2.41559651055649
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/130	137/9376	2.63222908478383	DDIT3/JUN/FOS/DAB2IP/PIK3R1	2.28196659240585
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/130	138/9376	2.61315496098105	PYGL/PPP1CB/TRIP10/SOS1/PIK3R1	2.26363824099921
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/130	59/9376	3.66727509778357	CTNNB1/SOS1/PIK3R1	2.43689119187359
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/130	99/9376	2.91406371406371	JUN/FOS/SOS1/PIK3R1	2.27012922122963
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/130	101/9376	2.85635948210206	JUN/EGR1/SERPINE1/PIK3R1	2.22405835575469
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/130	103/9376	2.80089619118745	JUN/FOS/SERPINE1/PIK3R1	2.17910186217035
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/130	103/9376	2.80089619118745	LAMC2/SERPINB9/ACTN4/PIK3R1	2.17910186217035
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/130	105/9376	2.74754578754579	JUN/MDM2/PLK3/PIK3R1	2.13520851319947
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/130	29/9376	4.97400530503979	YAP1/MOB1A	2.54139218406957
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/130	107/9376	2.69618979151689	PYGL/SIK1/PFKP/LDHA	2.0923303883408
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/130	253/9376	1.99550015202189	JUN/UBE2V1/MDM2/CYTH3/ACTN4/ACTR3C/PIK3R1	1.90332575198236
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/130	109/9376	2.64671841919548	PYGL/PPP1CB/GFPT1/PIK3R1	2.05042260235137
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/130	67/9376	3.22939150401837	ALDOA/PFKP/LDHA	2.17146382007359
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/130	157/9376	2.296913277805	DDIT3/JUN/XBP1/FOS/PIK3R1	1.9431182247901
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/130	68/9376	3.18190045248869	DUSP6/SOS1/PIK3R1	2.14112277567906
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/130	31/9376	4.6531017369727	ALDOA/PFKP	2.41564622269959
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/130	71/9376	3.04745395449621	FOS/SOS1/PIK3R1	2.05336189811699
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/130	116/9376	2.48700265251989	CTNNB1/EZR/ACTN4/PIK3R1	1.91080167931704
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/130	268/9376	1.88381171067738	DUSP1/DDIT3/XBP1/PSMA6/UBA1/SLC39A14/HSPA5	1.7405880902646
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/130	119/9376	2.42430510665805	JUN/FOS/DAB2IP/PIK3R1	1.85405131495162
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/130	35/9376	4.12131868131868	ALDOA/PFKP	2.19359181822162
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/130	75/9376	2.88492307692308	MDM2/SERPINE1/SFN	1.94329982160575
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/130	170/9376	2.12126696832579	JUN/PARD6B/EZR/ACTN4/ACTR3C	1.74935670355619
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/130	275/9376	1.83586013986014	HSPA1B/DDIT3/EGR1/CAV1/PSMA6/HSPA5/PIK3R1	1.66815259273361
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/130	76/9376	2.84696356275304	MDM2/SOS1/PIK3R1	1.91692013580961
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/130	122/9376	2.36469104665826	JUN/FOS/SOS1/PIK3R1	1.79899468326405
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/130	122/9376	2.36469104665826	PFKP/MDM2/CTNNB1/PIK3R1	1.79899468326405
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	6/130	224/9376	1.93186813186813	JUN/EGR1/FOSL1/FOS/ZFP36/PIK3R1	1.67378947711211
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/130	77/9376	2.80999000999001	MDM2/SOS1/PIK3R1	1.89096628812813
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/130	37/9376	3.8985446985447	UGDH/GFPT1	2.09464797470203
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/130	38/9376	3.79595141700405	UGDH/GFPT1	2.04774019004184
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/130	38/9376	3.79595141700405	SFN/PIK3R1	2.04774019004184
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/130	232/9376	1.86525198938992	PPP1CB/EZR/ACTN4/SOS1/ACTR3C/PIK3R1	1.58233655070553
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/130	130/9376	2.21917159763314	JUN/FOS/SOS1/PIK3R1	1.65973953113316
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/130	42/9376	3.43443223443223	SLC39A14/TFRC	1.87485984068816
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/130	86/9376	2.51592128801431	JUN/SOS1/PIK3R1	1.67455104352505
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/130	187/9376	1.92842451665981	HSP90AB1/JUN/OAS1/OAS3/HSP90AA1	1.52059531312126
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/130	138/9376	2.09052396878484	JUN/FOS/ACTR3C/PIK3R1	1.53026325317583
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/130	90/9376	2.40410256410256	JUN/FOS/PIK3R1	1.58703358444069
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/130	362/9376	1.59388015299618	HSP90AB1/LAMC2/MDM2/HSP90AA1/YWHAG/SOS1/EPHA2/PIK3R1	1.36639004717786
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/130	142/9376	2.03163596966414	MDM2/SKP2/UBA1/SMURF1	1.46877774346228
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/130	196/9376	1.83987441130298	JUN/FOS/CTNNB1/ZFP36/PIK3R1	1.40896892426761
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/130	93/9376	2.32655086848635	JUN/FOS/GATA3	1.52440925617002
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/130	93/9376	2.32655086848635	JUN/EGR1/SOS1	1.52440925617002
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/130	93/9376	2.32655086848635	LAMC2/SKP2/PIK3R1	1.52440925617002
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/130	144/9376	2.0034188034188	KLF4/CTNNB1/ID3/PIK3R1	1.43878517114749
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/130	200/9376	1.80307692307692	JUN/FOS/CYTH3/EZR/ACTR3C	1.36121213323383
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/130	95/9376	2.27757085020243	JUN/FOS/ATP6V0C	1.48398591947309
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/130	98/9376	2.20784929356358	ITPKC/PIK3R1/PIK3C2A	1.42521036843747
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/130	98/9376	2.20784929356358	ASAP2/ACTR3C/PIK3R1	1.42521036843747
NA	NA	hsa04518	Integrin signaling	4/130	154/9376	1.87332667332667	LAMC2/CTNNB1/ACTN4/PIK3R1	1.29570130432725
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/130	13/9376	5.54792899408284	RAD50	1.94562084148057
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/130	158/9376	1.82590068159688	MDM2/YWHAG/SKP2/SFN	1.24141899401319
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/130	158/9376	1.82590068159688	SKP2/SOS1/SLC7A5/PIK3R1	1.24141899401319
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/130	56/9376	2.57582417582418	SMURF1/MEGF8	1.40240737233037
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/130	56/9376	2.57582417582418	HSPA1B/HSPD1	1.40240737233037
NA	NA	hsa04382	Cornified envelope formation	5/130	217/9376	1.66182204891882	KRT19/LAMC2/COL17A1/KRT8/DSP	1.16957328309503
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/130	163/9376	1.76989145823502	JUN/FOS/SOS1/PIK3R1	1.17571792007196
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/130	109/9376	1.98503881439661	JUN/FOS/PIK3R1	1.22652775707638
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/130	110/9376	1.96699300699301	ID3/SMURF1/TFRC	1.20963375633224
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/130	110/9376	1.96699300699301	HSP90AB1/HSP90AA1/PIK3R1	1.20963375633224
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/130	112/9376	1.93186813186813	HSPA1B/LAMC2/IL10RB	1.17637169932973
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/130	227/9376	1.58861402914266	IL10RB/MDM2/CTNNB1/SOS1/PIK3R1	1.06447898880906
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/130	227/9376	1.58861402914266	GSTT2B/JUN/FOS/SOS1/PIK3R1	1.06447898880906
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/130	170/9376	1.69701357466063	GSTT2B/CTNNB1/SOS1/PIK3R1	1.08745321475301
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/130	17/9376	4.24253393665158	TFRC	1.5866262565272
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/130	62/9376	2.32655086848635	HSPA1B/PIK3R1	1.24260187910473
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/130	62/9376	2.32655086848635	HES1/DTX3L	1.24260187910473
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/130	63/9376	2.28962148962149	GTF2H2/ERCC5	1.21777794527589
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/130	173/9376	1.66758559359715	DNAJB1/OAS1/OAS3/PIK3R1	1.05086194811765
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/130	18/9376	4.00683760683761	NEU3	1.51403207306478
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/130	120/9376	1.80307692307692	JUN/SOS1/PIK3R1	1.04982392572292
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/130	66/9376	2.18554778554779	JUN/GATA3	1.1460315154541
NA	NA	hsa04517	IgSF CAM signaling	6/130	299/9376	1.44728582454335	CTNNB1/PARD6B/EZR/ACTN4/ACTR3C/PIK3R1	0.932030084415057
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/130	122/9376	1.77351828499369	FOS/SOS1/PIK3R1	1.019685214114
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/130	180/9376	1.60273504273504	OAS1/OAS3/PPP1CB/PIK3R1	0.968152080209236
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/130	181/9376	1.59388015299618	IL10RB/ATP6V0C/PLK3/HSPD1	0.956626929256046
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/130	20/9376	3.60615384615385	SQLE	1.38340808798313
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/130	20/9376	3.60615384615385	UGDH	1.38340808798313
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/130	69/9376	2.09052396878484	SOS1/PIK3R1	1.07804098864447
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/130	70/9376	2.06065934065934	EIF4G2/CAV1	1.05614558190594
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/130	71/9376	2.03163596966414	JUN/ATP6V0C	1.034612762931
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/130	73/9376	1.97597471022129	MDM2/PIK3R1	0.992587618710838
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/130	73/9376	1.97597471022129	SOS1/PIK3R1	0.992587618710838
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/130	75/9376	1.92328205128205	ALDOA/PFKP	0.95187642801692
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	7/130	388/9376	1.30118953211737	DDIT3/CDK5R1/XBP1/CTNNB1/PSMA6/SLC39A14/PIK3R1	0.718463276541432
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/130	78/9376	1.84930966469428	ITPKC/PIK3C2A	0.893097690646367
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/130	78/9376	1.84930966469428	JUN/FOS	0.893097690646367
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/130	78/9376	1.84930966469428	JUN/FOS	0.893097690646367
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/130	26/9376	2.77396449704142	HES1	1.07400465139789
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/130	80/9376	1.80307692307692	SOS1/PIK3R1	0.855331471815029
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/130	83/9376	1.73790546802595	EPOP/RYBP	0.80064901921586
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/130	144/9376	1.5025641025641	XBP1/PSMA6/PIK3R1	0.720618126605389
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/130	28/9376	2.57582417582418	ATP6V0C	0.990165505334886
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/130	86/9376	1.67728085867621	CTNNB1/DSP	0.7481532040106
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/130	212/9376	1.36081277213353	CTNNB1/PARD6B/EPHA2/PIK3R1	0.63006834710369
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/130	149/9376	1.4521424883841	CYTH3/SOS1/PIK3R1	0.659657590088124
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/130	150/9376	1.44246153846154	CTNNB1/SOS1/PIK3R1	0.647731173976498
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/130	214/9376	1.34809489575845	JUN/FOS/AP1G1/PIK3R1	0.610786975976409
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/130	89/9376	1.62074330164218	SDC4/LAMC2	0.697669427446312
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/130	31/9376	2.32655086848635	UGDH	0.877193635820676
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/130	31/9376	2.32655086848635	HSPA5	0.877193635820676
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/130	154/9376	1.40499500499501	JUN/PPP1CB/FOS	0.60086628777656
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/130	32/9376	2.25384615384615	PFKP	0.842428781721512
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/130	32/9376	2.25384615384615	LDHA	0.842428781721512
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/130	155/9376	1.39593052109181	DYNC1I2/ATP6V0C/TFRC	0.589353937438783
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/130	33/9376	2.18554778554779	STX6	0.808934259847178
Genetic Information Processing	Translation	hsa03010	Ribosome	4/130	222/9376	1.2995148995149	MRPL30/RPS17/RPL36A/MRPS17	0.53551277348504
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/130	34/9376	2.12126696832579	BHLHE40	0.77662063415708
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/130	226/9376	1.27651463580667	JUN/PPP1CB/FOS/PIK3R1	0.498932926471899
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/130	36/9376	2.0034188034188	UGDH	0.715221263003729
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/130	36/9376	2.0034188034188	PYGL	0.715221263003729
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/130	36/9376	2.0034188034188	GCNT4	0.715221263003729
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/130	99/9376	1.45703185703186	PPP1CB/PIK3R1	0.542051639168332
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/130	37/9376	1.94927234927235	GFPT1	0.685996460514236
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/130	37/9376	1.94927234927235	CTNNB1	0.685996460514236
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/130	168/9376	1.28791208791209	HSP90AB1/PYGL/HSP90AA1	0.446490532420418
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/130	168/9376	1.28791208791209	IL10RB/SOS1/PIK3R1	0.446490532420418
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/130	103/9376	1.40044809559373	PPP1CB/WDR82	0.484546080490893
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/130	103/9376	1.40044809559373	COL17A1/COL28A1	0.484546080490893
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/130	105/9376	1.37377289377289	JUN/SMURF1	0.456687927992944
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/130	41/9376	1.75909943714822	RAD50	0.577582207715314
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/130	41/9376	1.75909943714822	MDM2	0.577582207715314
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/130	108/9376	1.33561253561254	KPNA4/IPO5	0.415946437471243
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/130	178/9376	1.21555747623163	JUN/FOSL1/CTNNB1	0.344276008000918
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/130	44/9376	1.63916083916084	GTF2H2	0.50388276200549
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/130	44/9376	1.63916083916084	HSPD1	0.50388276200549
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/130	44/9376	1.63916083916084	DYNC1I2	0.50388276200549
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/130	323/9376	1.11645629911884	MDM2/EZR/SOS1/PDCD4/PIK3R1	0.252550571295359
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/130	184/9376	1.17591973244147	PARD6B/EPHA2/PIK3R1	0.285758284033552
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/130	46/9376	1.56789297658863	PSMA6	0.457809669592159
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/130	115/9376	1.2543143812709	FOS/PIK3R1	0.32536532540013
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/130	116/9376	1.24350132625995	ALDOA/PFKP	0.312899739852487
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/130	47/9376	1.53453355155483	LDHA	0.435598847855058
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/130	47/9376	1.53453355155483	PIK3R1	0.435598847855058
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/130	117/9376	1.23287310979619	BAZ1B/MORF4L2	0.300545757205953
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/130	48/9376	1.5025641025641	PIK3R1	0.413902628217921
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/130	191/9376	1.13282319774466	FOSB/PPP1CB/SOS1	0.219903126914573
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	7/130	480/9376	1.05179487179487	DDIT3/CDK5R1/XBP1/CTNNB1/PSMA6/UBA1/HSPA5	0.138130748063348
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/130	122/9376	1.18234552332913	PFKP/PIK3R1	0.240375744963945
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/130	51/9376	1.41417797888386	PAFAH1B2	0.35166410561681
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/130	51/9376	1.41417797888386	ATP6V0C	0.35166410561681
Organismal Systems	Immune system	hsa04611	Platelet activation	2/130	126/9376	1.14481074481074	PPP1CB/PIK3R1	0.194041920018067
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/130	54/9376	1.33561253561254	LDHA	0.293265431921597
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/130	54/9376	1.33561253561254	HES1	0.293265431921597
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/130	201/9376	1.07646383467279	DDIT3/DUSP6/MDM2	0.129936581344981
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/130	55/9376	1.31132867132867	NEU3	0.274567784102873
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/130	205/9376	1.05545966228893	PPP1CB/GFPT1/PIK3R1	0.0951976382850105
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/130	133/9376	1.08455754771544	SOS1/PIK3R1	0.116453378628661
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/130	133/9376	1.08455754771544	PPP1CB/FOS	0.116453378628661
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/130	134/9376	1.07646383467279	PPP1CB/ADM	0.105707514420178
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/130	59/9376	1.22242503259452	GSTT2B	0.203213235572214
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/130	59/9376	1.22242503259452	PIK3R1	0.203213235572214
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/130	60/9376	1.20205128205128	PIK3R1	0.186167070809448
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/130	138/9376	1.04526198439242	PPP1CB/YWHAG	0.0635132775290724
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/130	140/9376	1.03032967032967	EGR1/SERPINE1	0.0428716417820255
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	5/130	368/9376	0.979933110367893	DDIT3/XBP1/PSMA6/UBQLN1/HSPA5	-0.0465661306637829
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/130	63/9376	1.14481074481074	CTNNB1	0.13674348069468
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/130	65/9376	1.10958579881657	PIK3R1	0.105121890486392
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/130	67/9376	1.07646383467279	PPP1CB	0.0744770266849836
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/130	70/9376	1.03032967032967	GSTT2B	0.0302005989024077
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/130	233/9376	0.92862330802245	SDC4/TPM4/DSP	-0.130818867980269
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/130	154/9376	0.936663336663337	TPM4/PPP1CB	-0.0939687287741339
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/130	72/9376	1.0017094017094	ISG15	0.00172645753670943
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/130	73/9376	0.987987355110643	GSTT2B	-0.0122171224933098
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/130	238/9376	0.909114414996768	SOS1/EPHA2/PIK3R1	-0.16839852315945
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/130	75/9376	0.961641025641026	HSPA5	-0.0395469655719093
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/130	76/9376	0.948987854251012	PLIN2	-0.0529443088803182
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/130	76/9376	0.948987854251012	EZR	-0.0529443088803182
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/130	77/9376	0.936663336663337	PIK3R1	-0.0661702520517293
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/130	79/9376	0.912950340798442	GSTT2B	-0.0921275613042642
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/130	79/9376	0.912950340798442	ATP6V0C	-0.0921275613042642
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/130	82/9376	0.879549718574109	GSTT2B	-0.129895402792832
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/130	85/9376	0.848506787330317	GDA	-0.166361098064211
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/130	87/9376	0.829000884173298	TPM4	-0.189998153157917
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/130	88/9376	0.81958041958042	SERPINE1	-0.20162494921625
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/130	89/9376	0.810371650821089	SOS1	-0.213128198804958
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/130	90/9376	0.801367521367521	PIK3R1	-0.224510959961052
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/130	97/9376	0.743536875495638	FOS	-0.301051349669747
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/130	99/9376	0.728515928515929	KRT19	-0.321987151862318
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/130	99/9376	0.728515928515929	TPM4	-0.321987151862318
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/130	193/9376	0.7473893981666	SOS1/PIK3R1	-0.420453823006231
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/130	100/9376	0.721230769230769	IL10RB	-0.332311091202731
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/130	100/9376	0.721230769230769	TFRC	-0.332311091202731
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/130	194/9376	0.743536875495638	TPM4/DYNC1I2	-0.427993841157919
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/130	101/9376	0.714089870525514	CTNNB1	-0.342541850640154
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/130	105/9376	0.686886446886447	TPM4	-0.382572364610318
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/130	115/9376	0.627157190635452	DUSP1	-0.477008501783358
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/130	125/9376	0.576984615384615	PIK3R1	-0.564543222982629
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/130	128/9376	0.563461538461538	GDA	-0.58963595424957
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/130	243/9376	0.593605571383349	HSPA1B/WBP11	-0.761069859881322
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/130	138/9376	0.52263099219621	ATP6V0C	-0.669861710294305
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/130	250/9376	0.576984615384615	ATP6V0C/AP1G1	-0.8038338754014
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/130	143/9376	0.504357181280258	ACTN4	-0.708183475550687
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/130	144/9376	0.500854700854701	CTNNB1	-0.715715962478822
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/130	154/9376	0.468331668331668	UGDH	-0.788803745324828
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/130	155/9376	0.46531017369727	CTNNB1	-0.795901143390003
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/130	160/9376	0.450769230769231	SDC4	-0.83085260824743
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/130	166/9376	0.434476367006488	PPP1CB	-0.871676539308383
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/130	169/9376	0.426763768775603	PIK3R1	-0.891657942803887
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/130	308/9376	0.468331668331668	TGM2/PSMA6	-1.12496954398259
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/130	195/9376	0.369861932938856	PIK3R1	-1.05435872977279
NA	NA	hsa04081	Hormone signaling	1/130	219/9376	0.329329118370214	PIK3R1	-1.1907902531678
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	1/130	235/9376	0.306906710310966	SOS1	-1.27587797557393
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/130	254/9376	0.283949121744397	ITPKC	-1.37181666971214
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/130	298/9376	0.242023748064017	IL10RB	-1.57669979680421
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/130	370/9376	0.194927234927235	ADM	-1.87348575631306