category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/403	238/9376	4.10567800321121	C1QC/ISG15/C1QB/C1QA/MX1/OAS2/RPL41/OAS1/MX2/RPS10/CXCL10/RPS21/RPL39/FCGR2A/OAS3/RPL36A/RPL26/RPS29/RPL30/RPS19/IL1B/IFNAR1/RPL32/IFIH1/NFKBIA/RPL12/EIF2AK2/RPS15A/FAU/HBEGF/IL6/RPL17/TLR2/RPS25/MAPK1/RPL10A/STAT1/RPL5/RPL14/RPLP1/TAB2/RPS5	10.2846295973693
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/403	173/9376	3.89999856567076	MX1/OAS2/RSAD2/OAS1/ACTB/MX2/IRF7/CXCL10/OAS3/HLA-DRB1/HLA-DRA/IL1B/IFNAR1/HLA-DPA1/IFIH1/NFKBIA/IL1A/EIF2AK2/HLA-DMB/IL6/DNAJC3/MAPK1/FDPS/STAT1/ICAM1/SOCS3/HLA-DQA1/XPO1/APAF1	8.15878429131306
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/403	180/9376	3.61907912875655	B2M/HLA-C/OAS2/HLA-B/OAS1/IRF7/BST2/OAS3/CD74/HLA-DRB1/HLA-DRA/IL1B/IFNAR1/HLA-DPA1/IFIH1/NFKBIA/EIF2AK2/HLA-DMB/IL6/TLR2/PPP1CC/TAP1/STAT1/TAB2/HLA-E/SOCS3/HLA-DQA1/APAF1	7.51890709030422
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/403	155/9376	3.75250140078444	FCGR3A/HLA-C/HLA-B/ACTB/FCGR2A/TUBA1B/HLA-DRB1/HLA-DRA/HLA-DPA1/CTSS/HLA-DMB/TUBB/TLR2/ITGB5/ATP6V1C1/RAB5C/NCF2/STX7/TAP1/NCF1/CANX/ATP6V1A/COLEC12/HLA-E/HLA-DQA1	7.32274168121158
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/403	205/9376	3.29121830176118	B2M/ISG15/HLA-C/OAS2/HLA-B/OAS1/IRF7/CXCL10/OAS3/HLA-DRB1/HLA-DRA/IFNAR1/HLA-DPA1/NFKBIA/EIF2AK2/HLA-DMB/IL6/TLR2/PSMD8/TAP1/CIR1/STAT1/PSMD4/TAB2/HLA-E/ICAM1/HLA-DQA1/PSMD12/APAF1	7.02917540695821
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/403	78/9376	5.07068779029077	FCGR3A/FCGR2A/HLA-DRB1/HLA-DRA/EEF1A1/IL1B/HLA-DPA1/NFKBIA/IL1A/HLA-DMB/TLR2/MAPK1/NCF2/NCF1/STAT1/TAB2/HLA-DQA1	7.65049705611962
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/403	82/9376	4.82333716637415	B2M/HLA-C/HLA-B/HSP90AB1/CD74/HLA-DRB1/HLA-DRA/HSPA8/HLA-DPA1/CTSS/HLA-DMB/TAP1/LGMN/CANX/CTSB/HLA-E/HLA-DQA1	7.36915205926339
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	12/403	45/9376	6.20413564929694	HLA-C/HLA-B/HLA-DRB1/HLA-DRA/IL1B/HLA-DPA1/IL1A/HLA-DMB/IL6/CD80/HLA-E/HLA-DQA1	7.41583567372437
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	27/403	224/9376	2.80432470755051	B2M/HLA-C/HLA-B/ZFP36/HLA-DRB1/HLA-DRA/TGFBR1/HLA-DPA1/NFKBIA/ETS1/MAP3K1/HLA-DMB/IL6/MAPK1/FDPS/CANX/STAT5B/TSPO/ETS2/HLA-E/ICAM1/SPI1/HLA-DQA1/ELK4/ANAPC11/XPO1/SMAD4	5.79228639437674
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/403	44/9376	5.81637717121588	HLA-C/HLA-B/HLA-DRB1/HLA-DRA/IL1B/HLA-DPA1/IL1A/HLA-DMB/CD80/HLA-E/HLA-DQA1	6.78623336092866
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/403	95/9376	3.91840146271386	HLA-DRB1/HLA-DRA/IL1B/HLA-DPA1/CXCL1/IL1A/HLA-DMB/IL6/CXCL12/TLR2/ATP6V1C1/CD80/TNFSF13B/ATP6V1A/ICAM1/HLA-DQA1	6.05869064375019
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/403	181/9376	2.95639060636387	FCGR3A/FCGR2A/CD74/HLA-DRB1/HLA-DRA/IL1B/HLA-DPA1/IL1A/RIPK2/TLR1/CTSS/HLA-DMB/IL6/CEBPB/TLR2/HSPA9/MAPK1/RAB5C/IRAK2/STAT1/ARHGEF12/HLA-DQA1/APAF1	5.63233291275518
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/403	136/9376	3.25032841920887	MX1/OAS2/OAS1/MX2/IRF7/OAS3/IL1B/IFNAR1/HSPA8/IFIH1/NFKBIA/IL1A/EIF2AK2/IL6/TLR2/STAT1/STAT5B/TAB2/APAF1	5.60207218847184
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/403	70/9376	4.32073732718894	HLA-C/HLA-B/ACTB/HLA-DRB1/HLA-DRA/EIF4G1/HLA-DPA1/HLA-DMB/CD80/HLA-E/ICAM1/EIF4G2/HLA-DQA1	5.90978045302424
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/403	142/9376	3.11299059867892	FCGR3A/FCGR2A/TYROBP/IL1B/IFNAR1/TGFBR1/NFKBIA/IL1A/LCP2/MITF/MAPK1/NCF2/JUNB/NCF1/STAT1/TAB2/ATP2A2/SPI1/SOCS3	5.37670401252824
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/403	39/9376	5.36896354266081	HLA-C/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DMB/CD80/HLA-E/HLA-DQA1	5.79397173464106
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/403	156/9376	2.83361964751543	IFIT1/MX1/OAS2/RSAD2/OAS1/MX2/IRF7/CXCL10/OAS3/IFNAR1/NFKBIA/CD81/EIF2AK2/MAPK1/STAT1/SOS2/SOCS3/PPP2R1A/APAF1	4.89412908497266
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/403	250/9376	2.32655086848635	HLA-C/HLA-B/ARPC3/ARPC1B/SNX3/AP2S1/VPS4B/TGFBR1/HSPA8/EPN1/EPS15/CHMP5/RABEP1/BIN1/SH3KBP1/IST1/CYTH1/KIF5B/RAB5C/CLTA/PDCD6IP/ARRB2/HLA-E/ARRB1/CAPZA1	4.50529266164399
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	26/403	275/9376	2.19964809384164	C1QC/C1QB/C1QA/TUBA1B/IL1B/ATP5F1D/HSPA8/IL1A/PSMA7/ATP5F1E/PSMA2/IL6/COX6B1/UQCRB/TUBB/PSMD8/KIF5B/MAPK1/NCF2/NCF1/NDUFS5/PSMD4/ATP5PB/COX5A/PSMD12/APAF1	4.27902659196168
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/403	248/9376	2.25150084047066	ACTB/HSP90AB1/ARPC3/ARPC1B/TUBA1B/IL1B/NFKBIA/RIPK2/GAPDH/IL6/TUBB/TLR2/SNX9/CYTH1/KIF5B/PIK3CG/MAPK1/RAB5C/MYL12A/DYNLL2/HSP90B1/TAB2/DYNLRB1/DCTN2	4.23290476693772
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	19/403	174/9376	2.54048658053107	HSP90AB1/DNAJA1/HSPA8/OS9/RPN2/ERP29/DNAJC1/DNAJC3/SSR1/ERLEC1/CANX/HERPUD1/HSP90B1/SSR2/RAD23A/VCP/DNAJC5/UBXN1/STT3A	4.34671090320898
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	24/403	250/9376	2.2334888337469	LAPTM5/AP2S1/CTSC/AP1S2/GAA/CD68/CTSS/NCOA7/MITF/DNASE2/ATP6V1C1/CLTA/LGMN/LAMTOR4/CTSB/ATP6V1A/FUCA1/DMXL1/AP1B1/FUCA2/NAGLU/LAMTOR1/GALC/BLOC1S6	4.18923112782002
Genetic Information Processing	Translation	hsa03010	Ribosome	22/403	222/9376	2.30559095075224	RPL41/RPS10/RPS21/RPL39/RPL36A/RPL26/RPS29/RPL30/RPS19/RPL32/RPL12/RPS15A/FAU/MRPL20/RPL17/RPS25/RPL10A/RPL5/RPL14/MRPL41/RPLP1/RPS5	4.17203066446024
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/403	109/9376	2.98823047328522	HSP90AB1/HLA-DRB1/HLA-DRA/IL1B/TGFBR1/HLA-DPA1/NFKBIA/HLA-DMB/IL6/MAPK1/STAT1/STAT5B/HLA-DQA1/SMAD4	4.42465813043102
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/403	50/9376	4.18779156327543	HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DMB/IL6/CXCL12/CD80/TNFSF13B/HLA-DQA1	4.78957017658231
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/403	99/9376	3.05506679700228	C1QC/C1QB/C1QA/FCGR3A/FCGR2A/HLA-DRB1/HLA-DRA/HLA-DPA1/PTAFR/HLA-DMB/FPR1/ICAM1/HLA-DQA1	4.35621282174954
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/403	54/9376	3.87758478081059	HLA-C/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DMB/CD80/HLA-E/HLA-DQA1	4.49406951522805
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/403	66/9376	3.52507707346417	HLA-DRB1/HLA-DRA/IL1B/HLA-DPA1/IL1A/HLA-DMB/IL6/TLR2/STAT1/HLA-DQA1	4.36255678920651
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/403	56/9376	3.73909961006735	EEF1A1/IL1B/HSPA8/CXCL1/NFKBIA/IL6/TLR2/VCP/APAF1	4.35675572758053
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/403	196/9376	2.25532992353269	HLA-C/HLA-B/IRF7/UBC/ZFP36/IFNAR1/CXCL1/NFKBIA/EIF2AK2/IL6/CCR1/CD200R1/PIK3CG/HCK/MAPK1/GNG12/STAT1/HLA-E/ICAM1	3.76386383652762
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/403	112/9376	2.70046082949309	HLA-DRB1/HLA-DRA/HSPA8/HLA-DPA1/NFKBIA/HLA-DMB/TLR2/PIK3CG/MAPK1/STAT1/TAB2/HLA-DQA1/GNAI3	3.83659271531924
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/403	119/9376	2.54161019246408	CXCL10/IL1B/CXCL1/NFKBIA/TNFRSF1B/IL6/CEBPB/MAPK1/JUNB/MMP14/TAB2/ICAM1/SOCS3	3.58659426124272
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/403	105/9376	2.65891527827012	UBC/BNIP3L/MITF/NBR1/RAB5C/TOMM7/TBC1D15/FIS1/FKBP8/OPA1/TOMM20/VCP	3.62263762414224
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/403	42/9376	3.87758478081059	FTH1/FTL/SAT2/NCOA4/ACSL4/SLC3A2/ACSL3	3.96084823532207
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	19/403	214/9376	2.06562927575891	B2M/HLA-C/HLA-B/BST2/PAK2/SAMHD1/AP1S2/NFKBIA/TNFRSF1B/TLR2/MAPK1/GNG12/TAP1/TAB2/TRIM5/AP1B1/HLA-E/CUL4B/GNAI3	3.34185200876248
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/403	109/9376	2.56134040567305	IRF7/CXCL10/IL1B/IFNAR1/NFKBIA/TLR1/IL6/TLR2/MAPK1/CD80/STAT1/TAB2	3.47464623098585
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	17/403	187/9376	2.1150462440785	OAS2/OAS1/IRF7/HSP90AB1/OAS3/IL1B/IFNAR1/CXCL1/NFKBIA/RIPK2/IL6/MAPK1/STAT1/CTSB/TAB2/SUGT1/ATG12	3.26399048506387
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/403	83/9376	2.80307333552573	IRF7/CXCL10/IL1B/SAMHD1/NFKBIA/G3BP1/ZBP1/IL6/DNASE2/POLR2L	3.4965826311872
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/403	98/9376	2.61143464830101	MARCKS/FCGR3A/FCGR2A/ARPC3/ARPC1B/WAS/BIN1/HCK/MAPK1/NCF1/INPPL1	3.3983482254778
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/403	193/9376	2.04929351110197	CXCL10/CXCL1/NFKBIA/WAS/CXCL12/CCR1/PIK3CG/HCK/MAPK1/GNG12/NCF1/STAT1/STAT5B/SOS2/ARRB2/ARRB1/GNAI3	3.12142336501507
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/403	163/9376	2.14099773173591	IRF7/IFNAR1/TGFBR1/IFIH1/NFKBIA/MAP3K1/IL6/TLR2/MAPK1/STAT1/STAT5B/SOS2/TAB2/SMAD4/APAF1	3.11420627226606
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/403	103/9376	2.48466597605339	C1QC/C1QB/C1QA/IL1B/TGFBR1/NFKBIA/IL6/TLR2/MAPK1/PPP2R1A/GNAI3	3.21075055144762
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/403	138/9376	2.1916783543712	ACTB/FCGR2A/ARPC3/ARPC1B/IL1B/NFKBIA/LCP2/WAS/SKAP2/IL6/MAPK1/TAB2/ARHGEF12	2.98867673267887
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/403	94/9376	2.47505411541101	HSP90AB1/CXCL10/IL1B/CXCL1/NFKBIA/IL6/CEBPB/MAPK1/HSP90B1/TAB2	3.04593355844275
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/403	157/9376	2.07463134769484	C1QC/C1QB/C1QA/CH25H/CEBPB/SGK1/ITGB5/MAPK1/RAB5C/RAB14/PTGER4/DUSP2/ATP2A2/ADAM9	2.87764191832515
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/403	142/9376	2.12994093593821	UBC/UBE2L6/TRIP12/MAP3K1/UBE2R2/UBE2H/UBE2K/UBE2L3/UBE2I/SOCS3/ANAPC11/CUL4B/UBE2W	2.87524136074117
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/403	100/9376	2.32655086848635	HLA-DRB1/HLA-DRA/IL1B/HLA-DPA1/IL1A/CD59/CD33/HLA-DMB/IL6/HLA-DQA1	2.8262649048284
Human Diseases	Immune disease	hsa05310	Asthma	5/403	32/9376	3.63523573200993	HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DQA1	3.16444369212041
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	20/403	268/9376	1.73623199140773	TUBA1B/UBC/UBE2L6/ATP5F1D/PSMA7/ATP5F1E/PSMA2/COX6B1/UQCRB/TUBB/PSMD8/KIF5B/NDUFS5/PSMD4/UBE2L3/ATP5PB/COX5A/PSMD12/APAF1/GNAI3	2.59143248338064
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/403	200/9376	1.86124069478908	ACTB/FCGR2A/ARPC3/ARPC1B/TUBA1B/IL1B/PAK2/NFKBIA/GAPDH/MYH9/IL6/TUBB/CYTH1/MAPK1/TAB2/ARHGEF12	2.60904857856351
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/403	73/9376	2.5496447873823	MX1/MX2/BST2/VPS4B/SAMHD1/PDCD6IP/TRIM5/XPO1	2.81677013028129
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/403	46/9376	3.03463156759089	PSMA7/PSMA2/PSMD8/PSMD4/PSMD12/PSMB9	2.93152228324249
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/403	168/9376	1.93879239040529	FTH1/FTL/HSP90AB1/VPS4B/IL1B/IFNAR1/IL1A/EIF2AK2/CHMP5/ZBP1/STAT1/STAT5B/PARP1/PYGL	2.60202145736383
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/403	93/9376	2.25150084047066	ACTB/TGFBR1/WAS/PTPRJ/CTNNA1/PTPN1/MAPK1/MYL12A/SMAD4	2.57038259655109
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/403	93/9376	2.25150084047066	HLA-DRB1/HLA-DRA/HLA-DPA1/NFKBIA/HLA-DMB/MAPK1/STAT1/STAT5B/HLA-DQA1	2.57038259655109
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/403	78/9376	2.38620601896036	C1QC/C1QB/C1QA/IL1B/IL1A/IL6/MAPK1/GNAI3	2.60525140064206
Organismal Systems	Immune system	hsa04611	Platelet activation	11/403	126/9376	2.03111583756745	ACTB/FCGR2A/APBB1IP/TBXAS1/LCP2/PIK3CG/PPP1CC/MAPK1/MYL12A/ARHGEF12/GNAI3	2.46939856309049
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	21/403	308/9376	1.58628468305888	TUBA1B/AP2S1/ATP5F1D/PSMA7/ATP5F1E/PSMA2/COX6B1/UQCRB/TUBB/PSMD8/KIF5B/CLTA/NDUFS5/POLR2L/PSMD4/ATP5PB/POLR2J/COX5A/DCTN2/PSMD12/APAF1	2.217162263022
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	25/403	388/9376	1.49906628124121	TUBA1B/DKK2/IL1B/ATP5F1D/IL1A/GAPDH/EIF2AK2/PSMA7/ATP5F1E/PSMA2/IL6/COX6B1/CSNK1A1/UQCRB/TUBB/PSMD8/KIF5B/MAPK1/NDUFS5/PSMD4/ATP2A2/ATP5PB/COX5A/PSMD12/APAF1	2.12770731481603
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/403	101/9376	2.07316414023536	IL1B/TGFBR1/IL1A/IL6/MAPK1/STAT1/STAT5B/ICAM1/SMAD4	2.29794276475205
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/403	154/9376	1.81289678063872	KCNQ1/SCN1B/PIK3CG/PPP1CC/MAPK1/PPP2R5E/CREM/ATP1B3/TPM4/ATP2A2/PPP2R1A/GNAI3	2.15552236080631
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/403	72/9376	2.26192445547284	ISG15/IRF7/CXCL10/IFIH1/NFKBIA/MAP3K1/ATG12	2.27789699458167
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/403	227/9376	1.63985964298598	B2M/HLA-C/HLA-B/IL1B/NFKBIA/IL6/CXCL12/CCR1/MAPK1/PTGER4/GNG12/TAP1/SOS2/ARHGEF12/HLA-E/GNAI3	2.0681410816712
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/403	227/9376	1.63985964298598	ATP5F1D/NFKBIA/PTPRJ/ATP5F1E/PTPN1/COX6B1/UQCRB/MGST2/MAPK1/NCF2/NCF1/NDUFS5/SOS2/ATP5PB/COX5A/AKR1A1	2.0681410816712
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/403	105/9376	1.99418645870259	IL1B/CXCL1/NFKBIA/CXCL12/TNFSF13B/TAB2/ICAM1/UBE2I/PARP1	2.17104352337051
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/403	44/9376	2.64380780509813	ARHGDIA/RAB5C/DYNLL2/STX4/DCTN2	2.31611083795078
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	29/403	480/9376	1.40562448304384	TUBA1B/UBC/UBE2L6/DKK2/IL1B/ATP5F1D/IL1A/PSMA7/ATP5F1E/TNFRSF1B/PSMA2/IL6/COX6B1/CSNK1A1/UQCRB/TUBB/PSMD8/KIF5B/MAPK1/NDUFS5/PSMD4/UBE2L3/ATP2A2/ATP5PB/VCP/COX5A/DCTN2/PSMD12/APAF1	1.93337776488376
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	16/403	232/9376	1.60451784033542	TMSB4X/ACTB/ARPC3/ARPC1B/RDX/PAK2/MYH9/CXCL12/PPP1CC/ITGB5/MAPK1/MYL12A/GNG12/SOS2/ARHGEF12/FGD3	1.97585164689498
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/403	143/9376	1.78965451422027	C1QC/C1QB/C1QA/FCGR3A/FCGR2A/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DMB/CD80/HLA-DQA1	2.01652240083645
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	23/403	368/9376	1.45409429280397	ACTB/TUBA1B/ATP5F1D/PSMA7/ATP5F1E/TNFRSF1B/PSMA2/COX6B1/UQCRB/TUBB/PSMD8/KIF5B/NDUFS5/HNRNPA3/PSMD4/ATP5PB/NUP214/VCP/COX5A/NUP50/DCTN2/PSMD12/APAF1	1.88332421998608
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/403	216/9376	1.61566032533774	IRF7/HSP90AB1/IL1B/HSPA8/CXCL1/NFKBIA/IL6/TLR2/MAPK1/NCF2/NCF1/HSP90B1/TAB2/ICAM1/APAF1	1.93994596638574
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/403	78/9376	2.08793026659032	XRN1/HSPA9/LSM7/LSM8/CNOT6L/MTREX/NUDT16	2.04466855003344
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/403	333/9376	1.46719424138779	ISG15/MX1/HLA-C/HLA-B/MX2/OASL/IFNAR1/EIF2AK2/HES4/CSNK1A1/ITGB5/MAPK1/ATP6V1C1/PPP2R5E/PTGER4/STAT1/ATP6V1A/SOS2/HLA-E/RBL2/PPP2R1A	1.83963921947446
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/403	63/9376	2.21576273189176	RFC1/POLR2L/GTF2H1/RAD23A/POLR2J/CUL4B	2.05184063776392
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/403	205/9376	1.58886400774678	TGFBR1/ATP5F1D/GAPDH/ATP5F1E/COX6B1/UQCRB/PPP1CC/NCF2/NCF1/NDUFS5/ATP2A2/ATP5PB/COX5A/PARP1	1.80656221107994
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/403	133/9376	1.74928636728297	FCGR3A/HLA-C/HLA-B/TYROBP/IFNAR1/LCP2/MAPK1/SOS2/HLA-E/ICAM1	1.84432096206601
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/403	116/9376	1.80508257037734	ACTB/CTNNA1/CXCL12/SIPA1/NCF2/MYL12A/NCF1/ICAM1/GNAI3	1.84898442620726
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/403	50/9376	2.32655086848635	IL1B/CD81/IL6/TLR2/ICAM1	1.99310662297296
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/403	51/9376	2.28093222400623	ACTB/KCNQ1/ATP6V1C1/KDELR1/ATP6V1A	1.94382044813943
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/403	36/9376	2.58505652054039	CRYL1/UGP2/AKR1B1/AKR1A1	2.01925837457475
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/403	138/9376	1.68590642643939	ATP5F1D/ATP5F1E/ATP5MF/COX6B1/UQCRB/ATP6V1C1/NDUFS5/ATP6V1A/ATP5PB/COX5A	1.72022305345638
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/403	194/9376	1.55902893249085	ACTB/TUBA1B/MYH9/KIF1B/TUBB/KIF5B/MYL12A/DYNLL2/DYNLRB1/TPM4/KIF16B/DCTN2/CAPZA1	1.66738478220388
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/403	70/9376	1.99418645870259	APPL1/NFKBIA/TNFRSF1B/ACSL4/ACSL3/SOCS3	1.76931299329104
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/403	71/9376	1.96609932548142	MAPK1/STAT1/STAT5B/SOS2/SOCS4/SOCS3	1.73165787362677
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/403	56/9376	2.07727756114853	ST6GAL1/RPN2/MGAT5/MAN2A1/STT3A	1.71349562004882
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/403	108/9376	1.72337101369359	EEF1A1/TMEM33/KPNB1/NUP214/UBE2I/NUP50/XPO1/PHAX	1.60232015175604
NA	NA	hsa04517	IgSF CAM signaling	18/403	299/9376	1.40059918504195	ACTB/ARPC3/ARPC1B/TUBA1B/RDX/PAK2/LCP2/MYH9/PPFIA1/EPB41L2/TUBB/MAPK1/EPB41L3/MYL12A/CD80/DYNLL2/ICAM1/DOK2	1.49191408908211
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/403	43/9376	2.16423336603382	ECHS1/ACSL4/ADH5/ACSL3	1.62155978019686
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/403	77/9376	1.81289678063872	TGFBR1/NFKBIA/MAPK1/STAT5B/SOS2/SMAD4	1.51786088604567
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/403	170/9376	1.50541526784411	ACTB/ARPC3/ARPC1B/TUBA1B/RDX/WAS/MAP3K1/MYH9/WHAMM/MYL12A/PPP2R1A	1.40931041026542
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/403	61/9376	1.90700890859537	FTH1/FTL/MT2A/ATOX1/ATP1B3	1.50610194017002
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/403	115/9376	1.61847016938181	WNK1/HBEGF/SGK1/MAPK1/MMP14/ARRB2/ARRB1/GNAI3	1.41419097920359
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/403	253/9376	1.37937798526859	ACTB/ARPC3/ARPC1B/UBC/CAST/IL1B/NFKBIA/RIPK2/FNBP1/CBX3/CYTH1/MAPK1/MYL12A/TAB2/ATG12	1.29638165394671
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/403	46/9376	2.02308771172726	FTH1/FTL/BLVRA/BLVRB	1.47407740664874
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/403	137/9376	1.52839108148738	ACTB/TUBA1B/CTSC/NFKBIA/CTSS/MAPK1/CTSB/PARP1/APAF1	1.32029994785756
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/403	157/9376	1.48187953406774	HLA-C/HLA-B/TGFBR1/IL1A/ETS1/IL6/PPP1CC/MAPK1/HLA-E/RBL2	1.29037436865289
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/403	138/9376	1.51731578379545	PTPN1/PPP1CC/MAPK1/FLOT1/SOS2/SOCS4/SOCS3/INPPL1/PYGL	1.29740516038222
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/403	31/9376	2.25150084047066	SPCS3/SEC11A/SPCS2	1.47908000833298
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/403	300/9376	1.3183788254756	TAOK3/MAP4K4/IL1B/TGFBR1/HSPA8/PAK2/IL1A/MAP3K1/MAPK1/STMN1/GNG12/SOS2/TAB2/ARRB2/DUSP2/ARRB1/ELK4	1.18775505496829
NA	NA	hsa03272	Virion - Hepatitis viruses	4/403	48/9376	1.93879239040529	VPS4B/CD81/IST1/PDCD6IP	1.38186379383178
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/403	160/9376	1.45409429280397	HLA-C/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DMB/CD80/HLA-E/ICAM1/HLA-DQA1	1.2277335652646
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/403	122/9376	1.5256071268763	MAP3K1/MAPK1/JUNB/STAT1/STAT5B/SOS2/SOCS3/GNAI3	1.238356649484
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/403	32/9376	2.18114143920596	GAA/UGP2/AKR1B1	1.4183382273534
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/403	142/9376	1.47457449411107	ACTB/HSP90AB1/IL1B/IL1A/MGST2/NCF2/NCF1/HSP90B1/ICAM1	1.20759959288313
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/403	49/9376	1.89922519876437	GALNT1/ST6GAL1/C1GALT1/COLGALT1	1.33741086655193
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/403	144/9376	1.45409429280397	C1QC/C1QB/C1QA/IL1B/CXCL1/NFKBIA/IL6/ADH5/TAB2	1.1637205917612
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/403	68/9376	1.71069916800467	MAPK1/STAT5B/SOS2/SPI1/CEBPA	1.24646877471713
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/403	33/9376	2.1150462440785	STX11/STX7/STX4	1.35980302220246
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/403	87/9376	1.60451784033542	COX6B1/UQCRB/ATP1B3/TPM4/ATP2A2/COX5A	1.20047631062731
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/403	18/9376	2.58505652054039	ACSL4/ACSL3	1.42645742053428
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/403	18/9376	2.58505652054039	FUCA1/FUCA2	1.42645742053428
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/403	71/9376	1.63841610456785	CXCL1/NFKBIA/HBEGF/ATP6V1C1/ATP6V1A	1.14431119551207
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/403	130/9376	1.43172361137622	TGFBR1/NFKBIA/MAPK1/GNG12/SOS2/ARRB2/ARRB1/GNAI3	1.05043663619585
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/403	91/9376	1.53398958361738	IFITM1/NFKBIA/CD81/MAPK1/SOS2/INPPL1	1.08475548544885
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/403	36/9376	1.93879239040529	GAA/UGP2/PYGL	1.19596012618317
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/403	20/9376	2.32655086848635	UGP2/CYB5R4	1.25852870901989
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/403	37/9376	1.88639259607002	IL1B/IL6/ICAM1	1.14484349683566
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/403	235/9376	1.28702814001373	ACTB/ATP5F1D/ATP5F1E/ATP5MF/NDUFAF3/COX6B1/UQCRB/NDUFS5/ACSL4/SOS2/ATP5PB/ACSL3/COX5A	0.94434542522876
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/403	133/9376	1.39942909382638	TGFBR1/IL6/SGK1/MAPK1/SOS2/RBL2/ATG12/SMAD4	0.983169429966166
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/403	133/9376	1.39942909382638	KIF5B/PPP1CC/PPP2R5E/GNG12/ARRB2/ARRB1/PPP2R1A/GNAI3	0.983169429966166
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/403	38/9376	1.83675068564712	SGK1/MAPK1/ATP1B3	1.09529288826177
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/403	217/9376	1.28657190884038	HSP90AB1/PTGES3/MGST2/MAPK1/STAT5B/SOS2/HSP90B1/KPNB1/ARRB2/KLF4/ARRB1/GNAI3	0.905125460239995
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/403	157/9376	1.33369158066097	IL1B/IL1A/IL6/COX6B1/UQCRB/NDUFS5/SOCS3/COX5A/CEBPA	0.893557481234818
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/403	77/9376	1.51074731719893	TGFBR1/MAPK1/RALBP1/STAT1/SMAD4	0.953679967609033
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/403	117/9376	1.39195351106021	ACTB/SMARCA5/BAZ1A/YY1/ZNHIT1/SMARCA1/RBBP7	0.904096473744387
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/403	78/9376	1.49137876185023	ACTB/ARPC3/ARPC1B/CTNNA1/CLTA	0.923502848816202
Genetic Information Processing	Transcription	hsa03040	Spliceosome	13/403	243/9376	1.24465684322315	HSPA8/CDC5L/CDC40/SF3B2/RBM17/LSM7/PRPF8/HNRNPA3/LSM8/SYF2/SF3B5/ZMAT2/DHX16	0.818885352972916
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/403	59/9376	1.57732262270261	HPGDS/GSTK1/MGST2/LAP3	0.94270511034394
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/403	120/9376	1.35715467328371	NFKBIA/ARHGDIA/RIPK2/MAP3K1/MAPK1/IRAK2/SOS2	0.83445825354949
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/403	100/9376	1.39593052109181	CXCL10/CXCL1/TNFRSF1B/IL6/CXCL12/CCR1	0.843544384987692
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/403	23/9376	2.02308771172726	FDPS/IDI1	1.04104774225623
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/403	23/9376	2.02308771172726	NLN/ATP6AP2	1.04104774225623
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/403	23/9376	2.02308771172726	GLS/ATP1B3	1.04104774225623
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/403	205/9376	1.2483931489439	HLA-C/HLA-B/IRF7/NFKBIA/EIF2AK2/MAPK1/STAT5B/GTF2A1/GTF2H1/HLA-E/RBL2	0.762039571904281
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/403	122/9376	1.33490623601676	PAK2/NFKBIA/LCP2/MAPK1/PPP2R5E/SOS2/PPP2R1A	0.789055823481293
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	8/403	144/9376	1.2925282602702	PSMA7/PSMA2/PSMD8/NOP56/PSMD4/OPA1/ATP2A2/PSMD12	0.74967064229425
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/403	83/9376	1.40153666776286	DCAF7/CBX3/YY1/RBBP7/KDM2B	0.778673895632228
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/403	83/9376	1.40153666776286	GSTK1/ACSL4/PRDX5/ACSL3/MPV17	0.778673895632228
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/403	63/9376	1.47717515459451	HPGDS/LTC4S/TBXAS1/PTGES3	0.805327674426083
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/403	44/9376	1.58628468305888	RPN2/MAN2A1/STT3A	0.826069996958156
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/403	44/9376	1.58628468305888	GTF2I/GTF2A1/GTF2H1	0.826069996958156
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/403	44/9376	1.58628468305888	RFC1/APEX1/PARP1	0.826069996958156
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/403	168/9376	1.24636653668912	IFNAR1/IL6/IL13RA1/STAT1/STAT5B/OSM/SOS2/SOCS4/SOCS3	0.682846411403848
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/403	105/9376	1.32945763913506	IL1B/NFKBIA/IL6/MAPK1/STAT1/ARHGEF12	0.719449422598786
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/403	106/9376	1.31691558593567	HSP90AB1/NFKBIA/MAPK1/ETV5/SOS2/HSP90B1	0.695386077492774
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/403	86/9376	1.35264585377113	PAK2/HBEGF/MAPK1/STAT5B/SOS2	0.696224782255061
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/403	87/9376	1.33709820027951	APPL1/TGFBR1/MAPK1/SOS2/SMAD4	0.669423426058232
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/403	67/9376	1.38898559312618	GAPDH/TPI1/ADH5/AKR1A1	0.677155998930072
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/403	109/9376	1.28067020283652	NFKBIA/IL6/PTPN1/PPP1CC/SOCS3/PYGL	0.624610532650355
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/403	47/9376	1.48503246924661	MAPK1/SOCS4/SOCS3	0.706433884295465
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/403	89/9376	1.30705104971143	TUBA1B/TUBB/MAPK1/SOS2/GNAI3	0.616789816062773
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/403	28/9376	1.66182204891882	GCH1/AKR1B1	0.743241965247449
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/403	28/9376	1.66182204891882	ATP6V1C1/ATP6V1A	0.743241965247449
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/403	70/9376	1.32945763913506	PAK2/ETS1/MAPK1/SOS2	0.586322290510122
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/403	201/9376	1.15748799427182	ETV7/FLI1/IL6/MITF/CEBPB/HHEX/ETV5/SPI1/ELK4/CEBPA	0.478312545083969
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/403	50/9376	1.39593052109181	LAP3/SAT2/GATM	0.594874846168286
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/403	158/9376	1.17800043973993	SGK1/MAPK1/ATP6V1C1/LAMTOR4/ATP6V1A/SOS2/SLC3A2/LAMTOR1	0.478190114909913
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/403	93/9376	1.25083380026148	MAP3K1/HBEGF/MAPK1/SOS2/MMP14	0.515172514447858
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/403	30/9376	1.55103391232423	IL1B/IL6	0.64061247830255
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/403	73/9376	1.27482239369115	HPGDS/GSTK1/MGST2/ADH5	0.499541260025977
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/403	73/9376	1.27482239369115	KIF5B/MAPK1/STAT5B/SOS2	0.499541260025977
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/403	139/9376	1.17164432225931	HSP90AB1/HSPA8/HBEGF/MAPK1/SOS2/HSP90B1/GNAI3	0.43205665390332
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/403	53/9376	1.31691558593567	AP2S1/CLTA/ATP1B3	0.490312560031866
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/403	32/9376	1.45409429280397	ECHS1/ECHDC1	0.545285494969901
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/403	298/9376	1.09301047512782	CXCL10/IL1B/IFNAR1/TGFBR1/CXCL1/IL1A/TNFRSF1B/TNFSF9/IL6/CXCL12/IL13RA1/CCR1/TNFSF13B/OSM	0.345791435965232
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/403	76/9376	1.22450045709808	ACTB/KCNQ1/ATP1B3/GNAI3	0.416439464025999
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/403	99/9376	1.17502569115472	ACTB/IL6/ITGB5/TPM4/ATP2A2	0.371009429501739
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/403	55/9376	1.2690277464471	SGMS1/GALC/CERS6	0.424049437899901
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/403	34/9376	1.36855933440374	POLR2L/POLR2J	0.45624305789547
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/403	78/9376	1.19310300948018	TPI1/PIK3CG/PI4K2A/INPPL1	0.362919998207584
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/403	56/9376	1.24636653668912	CSNK1A1/ARRB2/ARRB1	0.391865566282964
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/403	13/9376	1.78965451422027	XRCC5	0.603768726848543
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/403	79/9376	1.17800043973993	HPGDS/GSTK1/MGST2/ADH5	0.336691794828798
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/403	79/9376	1.17800043973993	AP2S1/ATP6V1C1/CLTA/ATP6V1A	0.336691794828798
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/403	57/9376	1.22450045709808	ECHS1/ACSL4/ACSL3	0.360279315506259
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/403	35/9376	1.32945763913506	TPI1/AKR1B1	0.413815015779853
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/403	125/9376	1.11674441687345	SGMS1/MAPK1/PPP2R5E/CERS6/PPP2R1A/GNAI3	0.278462112606366
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/403	103/9376	1.12939362547881	IL1B/CXCL1/IL6/TLR2/RAB5C	0.279827692599431
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/403	36/9376	1.2925282602702	GALNT1/C1GALT1	0.372661877791583
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/403	195/9376	1.07379270853216	FCGR3A/ACTB/FCGR2A/FPR1/TLR2/CLCN3/MAPK1/NCF2/NCF1	0.220675993568362
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/403	59/9376	1.18299196702696	CTNNA1/MAPK1/SOS2	0.298805998040831
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/403	37/9376	1.25759506404668	MAPK1/NCOA4	0.332703629518481
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/403	60/9376	1.16327543424318	MAPK1/PPP2R1A/GNAI3	0.268875394206365
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/403	15/9376	1.55103391232423	ST3GAL5	0.452618354902722
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	16/403	362/9376	1.02830977612656	HSP90AB1/IFNAR1/IL6/SGK1/TLR2/CDC37/PIK3CG/ITGB5/MAPK1/PPP2R5E/GNG12/OSM/SOS2/HSP90B1/RBL2/PPP2R1A	0.116412943573004
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/403	85/9376	1.09484746752299	CMPK2/APRT/LACC1/NUDT16	0.186154397392159
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/403	86/9376	1.08211668301691	ACTB/CTNNA1/ITGB5/ATP2A2	0.162122052879881
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/403	110/9376	1.05752312203925	HSP90AB1/MAPK1/STK10/ANAPC11/GNAI3	0.128606219277698
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	9/403	204/9376	1.0264195008028	ACTB/RDX/HBEGF/TLR2/PPP1CC/ITGB5/MAPK1/SOS2/ARHGEF12	0.080849436145882
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/403	17/9376	1.36855933440374	CH25H	0.322319424820056
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/403	17/9376	1.36855933440374	SEPHS2	0.322319424820056
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/403	17/9376	1.36855933440374	MYH9	0.322319424820056
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/403	88/9376	1.05752312203925	C1QC/C1QB/C1QA/CD59	0.114892587216831
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/403	41/9376	1.13490286267627	HBEGF/MAPK1	0.183453186741955
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/403	65/9376	1.07379270853216	MAPK1/ARRB2/ARRB1	0.126514788452213
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/403	90/9376	1.03402260821616	NFKBIA/TLR2/MAPK1/STAT1	0.0687296047799813
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/403	91/9376	1.02265972241158	GNG12/ARRB2/ARRB1/GNAI3	0.0460313439415818
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/403	115/9376	1.01154385586363	KCNQ1/PIK3CG/MAPK1/GNG12/GNAI3	0.0263961265001543
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/403	116/9376	1.00282365020963	GAPDH/TPI1/ECHS1/ADH5/PGLS	0.00648490658569878
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/403	140/9376	0.997093229351294	TGFBR1/PIK3CG/MAPK1/GNG12/SMAD4/GNAI3	-0.00734348393867906
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/403	19/9376	1.22450045709808	NAGLU	0.207584557552711
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/403	69/9376	1.01154385586363	LCP2/MAPK1/SOS2	0.0203957608649244
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/403	69/9376	1.01154385586363	PTGER4/CTSB/GNAI3	0.0203957608649244
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/403	166/9376	0.981075667434004	GTF2I/PIK3CG/PPP1CC/MAPK1/ATP1B3/ATP2A2/GNAI3	-0.0521331693344878
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/403	70/9376	0.997093229351294	HPGDS/GSTK1/MGST2	-0.00517306088033471
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/403	170/9376	0.957991534082616	ACTB/TGFBR1/CSNK1A1/MGST2/MAPK1/SOS2/SMAD4	-0.117137277212034
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/403	47/9376	0.990021646164405	ADH5/AKR1A1	-0.0145331451106828
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/403	122/9376	0.953504454297685	ACTB/MAPK1/STAT1/ATP1B3/ATP2A2	-0.109545828524125
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/403	99/9376	0.940020552923779	WAS/MAPK1/LYPLA1/SOS2	-0.127140994529237
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/403	150/9376	0.930620347394541	TGFBR1/CTNNA1/CSNK1A1/MAPK1/SOS2/SMAD4	-0.181526633163741
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/403	75/9376	0.930620347394541	MGST2/MAPK1/APAF1	-0.127840145964425
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/403	75/9376	0.930620347394541	SESN1/EI24/APAF1	-0.127840145964425
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/403	75/9376	0.930620347394541	CANX/HSP90B1/ATP1B3	-0.127840145964425
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/403	23/9376	1.01154385586363	GLS	0.0117465051588544
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/403	23/9376	1.01154385586363	RFC1	0.0117465051588544
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/403	76/9376	0.91837534282356	UBC/ACSL4/ACSL3	-0.151410509026323
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/403	103/9376	0.903514900383049	PPP1CC/PPP2R5E/PAPOLA/PPP2R1A	-0.208659450541933
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/403	52/9376	0.894827257110136	TSPO/LRPAP1	-0.161165866388817
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/403	105/9376	0.886305092756706	ACTB/ITGB5/TPM4/ATP2A2	-0.248279977915699
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/403	157/9376	0.889127720440644	ACTB/TGFBR1/CTNNA1/PPP1CC/PPP2R1A/SMAD4	-0.296893181019384
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/403	80/9376	0.872456575682382	IL6/MAPK1/SOS2	-0.242786389218903
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/403	158/9376	0.883500329804944	STAG2/PPP2R5E/RBL2/PPP2R1A/ANAPC11/SMAD4	-0.312971084559885
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/403	26/9376	0.894827257110136	HHEX	-0.113802917601696
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/403	54/9376	0.861685506846797	MTAP/LACC1	-0.216012731002466
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/403	27/9376	0.861685506846797	ECHS1	-0.152523344285488
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/403	110/9376	0.846018497631401	TGFBR1/MAPK1/PPP2R1A/SMAD4	-0.34426119717238
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/403	28/9376	0.830911024459411	ECHS1	-0.189890957377093
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/403	138/9376	0.842953213219693	PPP1CC/MAPK1/PPP2R5E/PPP2R1A/ANAPC11	-0.393866411914435
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/403	169/9376	0.825994391178587	UBC/NBR1/MAPK1/STX7/CTSB/ATG12	-0.483745408033661
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/403	116/9376	0.802258920167708	MAPK1/GLS/GNG12/GNAI3	-0.454139973319693
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/403	89/9376	0.78423062982686	GLS/GNG12/GNAI3	-0.433427439072896
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/403	31/9376	0.750500280156888	PGLS	-0.294869995904951
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/403	31/9376	0.750500280156888	AKR1A1	-0.294869995904951
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/403	31/9376	0.750500280156888	ECHS1	-0.294869995904951
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/403	62/9376	0.750500280156888	NRARP/CIR1	-0.417702541423817
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/403	32/9376	0.727047146401985	ATG12	-0.327767237413602
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/403	32/9376	0.727047146401985	APAF1	-0.327767237413602
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/403	63/9376	0.738587577297255	ECHS1/COLGALT1	-0.441185288911755
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/403	65/9376	0.715861805688108	AKR1B1/AKR1A1	-0.48714411301077
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/403	122/9376	0.762803563438148	PPP2R5E/RAB14/RAB2A/PPP2R1A	-0.558846654526833
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	7/403	203/9376	0.802258920167708	ACTB/PAK2/PPP1CC/ITGB5/MAPK1/MYL12A/SOS2	-0.603612953358381
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/403	67/9376	0.69449279656309	PPP1CC/MAPK1	-0.531834698198054
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/403	233/9376	0.798815748836516	ACTB/TMOD3/MYH9/ITGB5/ATP1B3/TPM4/FMNL2/CAPZA1	-0.659017441699355
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/403	97/9376	0.719551814995779	MAPK1/GNG12/GNAI3	-0.588379104403009
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/403	36/9376	0.646264130135098	RFC1	-0.450636370600001
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/403	68/9376	0.684279667201868	ALDH1A1/ADH5	-0.553730121115864
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/403	154/9376	0.755373658599465	ACTB/PIK3CG/PPP1CC/MAPK1/GNAI3	-0.648664826199434
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/403	37/9376	0.628797532023339	GLS	-0.479436237798696
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/403	37/9376	0.628797532023339	ADH5	-0.479436237798696
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/403	37/9376	0.628797532023339	UGP2	-0.479436237798696
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/403	99/9376	0.705015414692834	HBEGF/MAPK1/SOS2	-0.625291418560212
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/403	99/9376	0.705015414692834	IL1B/PPP1CC/PTGER4	-0.625291418560212
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/403	184/9376	0.758657891897724	PAK2/CXCL12/MAPK1/MYL12A/ARHGEF12/GNAI3	-0.700658399977865
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/403	238/9376	0.782033905373564	PAK2/ETS1/MAPK1/RALBP1/RAB5C/GNG12/SOS2/ETS2	-0.72180713702456
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/403	38/9376	0.61225022854904	UGP2	-0.507558074800874
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/403	38/9376	0.61225022854904	TAP1	-0.507558074800874
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/403	212/9376	0.768200758462475	ACTB/APBB1IP/LCP2/FPR1/MAPK1/SIPA1/GNAI3	-0.723447013571717
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/403	101/9376	0.691054713411788	MITF/MAPK1/GNAI3	-0.661537745627551
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/403	71/9376	0.655366441827142	MAPK1/GLS	-0.617728838832021
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/403	102/9376	0.684279667201868	KCNQ1/ATP1B3/ATP2A2	-0.679420144587361
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/403	103/9376	0.677636175287287	KCNQ1/SLC3A2/ATP1B3	-0.697146593683297
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/403	73/9376	0.637411196845576	MITF/MAPK1	-0.659073175101681
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/403	104/9376	0.671120442832602	SGMS1/ETNK1/LYPLA1	-0.714720377588498
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/403	134/9376	0.69449279656309	MYH9/PPP1CC/MAPK1/ARHGEF12	-0.754849200233409
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/403	41/9376	0.567451431338135	GATM	-0.588218898898498
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/403	75/9376	0.620413564929694	GAPDH/TPI1	-0.699432520100073
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/403	42/9376	0.553940682972941	ECHS1	-0.613977829768029
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/403	76/9376	0.61225022854904	MAPK1/SOS2	-0.719260482078645
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/403	110/9376	0.634513873223551	GAPDH/IL6/MAPK1	-0.817128613622458
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/403	45/9376	0.517011304108078	TAP1	-0.68825354340731
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/403	115/9376	0.606926313518179	MAPK1/GNG12/GNAI3	-0.898800441968801
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/403	48/9376	0.484698097601323	ECHS1	-0.758503210182555
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/403	48/9376	0.484698097601323	ATP1B3	-0.758503210182555
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/403	49/9376	0.474806299691092	GNAI3	-0.781116635524584
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/403	149/9376	0.624577414358752	CYTH1/PIK3CG/MAPK1/SOS2	-0.978932163466294
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/403	149/9376	0.624577414358752	MAPK1/GNG12/NDUFS5/GNAI3	-0.978932163466294
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/403	154/9376	0.604298926879572	CMPK2/GCH1/UGP2/AKR1A1	-1.04926299577168
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/403	90/9376	0.517011304108078	APPL1/SESN1	-0.975693044194255
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/403	93/9376	0.500333520104592	CST3/ATP1B3	-1.02623504712956
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/403	93/9376	0.500333520104592	NFKBIA/APAF1	-1.02623504712956
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/403	128/9376	0.545285359801489	APRT/LACC1/NUDT16	-1.09771434303301
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/403	191/9376	0.609044729970249	PPP1CC/MAPK1/GNG12/SOS2/GNAI3	-1.15684054779792
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/403	59/9376	0.394330655675653	CMPK2	-0.988992226565388
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/403	59/9376	0.394330655675653	GNAI3	-0.988992226565388
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/403	98/9376	0.474806299691092	PI4K2A/INPPL1	-1.10757893989599
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/403	226/9376	0.617668372164518	NFKBIA/PPP1CC/MAPK1/ATP1B3/ATP2A2/GNAI3	-1.23297203312801
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/403	60/9376	0.387758478081059	MAPK1	-1.00821462407068
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/403	62/9376	0.375250140078444	HSPA8	-1.04593145197719
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/403	107/9376	0.434869321212402	PPP4R3A/PYGL	-1.24593004651716
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/403	144/9376	0.484698097601323	MAPK1/KLF4/SMAD4	-1.32057910504048
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/403	178/9376	0.522820419884574	DKK2/TBL1XR1/CSNK1A1/SMAD4	-1.36211719887404
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/403	69/9376	0.337181285287877	PPP1CC	-1.17107248754337
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/403	148/9376	0.471598149017504	CSNK1A1/MAPK1/SOS2	-1.37312704935887
NA	NA	hsa04081	Hormone signaling	5/403	219/9376	0.531175997371313	APPL1/GNG12/STAT5B/SMAD4/GNAI3	-1.48773169732362
NA	NA	hsa04518	Integrin signaling	3/403	154/9376	0.453224195159679	ACTB/ITGB5/ICAM1	-1.44986116534393
NA	NA	hsa04519	Cadherin signaling	11/403	404/9376	0.633466820627472	ACTB/ARPC3/ARPC1B/TAOK3/NFKBIA/CTNNA1/SCN1B/CSNK1A1/PPP1CC/MAPK1/LHFPL2	-1.59598450845559
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/403	82/9376	0.283725715669067	MGST2	-1.38055679833762
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/403	86/9376	0.270529170754227	ATP1B3	-1.44018613524566
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/403	89/9376	0.261410209942287	ITGB5	-1.48364469420857
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/403	90/9376	0.258505652054039	ATP1B3	-1.49790436868137
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/403	98/9376	0.237403149845546	ATP1B3	-1.60823751382641
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/403	183/9376	0.381401781719074	XRN1/NOP56/XPO1	-1.79091472387747
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/403	323/9376	0.504206070569798	MARCKS/RDX/MAPK1/STMN1/GLS/SOS2/UBE2I	-1.92165550012318
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/403	155/9376	0.300200112062755	MAPK1/GNAI3	-1.86174430517813
NA	NA	hsa04082	Neuroactive ligand signaling	3/403	199/9376	0.350736311832113	P2RX4/GNG12/GNAI3	-1.96185368329859
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/403	370/9376	0.377278519214003	PTAFR/FPR1/P2RX4/PTGER4/PGRMC2/TSPO	-2.58998986774677
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/403	254/9376	0.274789472655868	PTAFR/P2RX4/ATP2A2	-2.48316313188946
NA	NA	hsa04382	Cornified envelope formation	2/403	217/9376	0.214428651473397	PPP2R5E/PPP2R1A	-2.48119444527463
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/403	449/9376	0.103632555389147	ARRB2/ARRB1	-4.1250175956261