ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0044389 ubiquitin-like protein ligase binding 40/647 322/18639 0.124223602484472 3.57867654823505 2.67915378692758e-12 2.30675141054465e-09 GO:0031625 ubiquitin protein ligase binding 38/647 302/18639 0.125827814569536 3.62489124538113 6.44191532889192e-12 2.77324454908797e-09 GO:0045296 cadherin binding 37/647 334/18639 0.110778443113772 3.19134374219104 4.97703976598831e-10 1.42841041283864e-07 GO:0003735 structural constituent of ribosome 24/647 175/18639 0.137142857142857 3.95085890925149 9.39258617061293e-09 2.01824448022283e-06 GO:0023026 MHC class II protein complex binding 10/647 27/18639 0.37037037037037 10.6697578567749 1.17203512208062e-08 2.01824448022283e-06 GO:0042277 peptide binding 27/647 249/18639 0.108433734939759 3.12379657734493 1.73565558193006e-07 2.49066576006964e-05 GO:0003725 double-stranded RNA binding 14/647 75/18639 0.186666666666667 5.37755795981453 2.54035737227675e-07 3.12463956790041e-05 GO:0023023 MHC protein complex binding 10/647 37/18639 0.27027027027027 7.78603951710598 3.53451464516701e-07 3.804021386861e-05 GO:0042605 peptide antigen binding 10/647 45/18639 0.222222222222222 6.40185471406491 2.51911190258615e-06 0.000240995038680742 GO:0031386 protein tag activity 6/647 15/18639 0.4 11.5233384853168 6.54397672342608e-06 0.000512214905351805 GO:0141047 molecular tag activity 6/647 15/18639 0.4 11.5233384853168 6.54397672342608e-06 0.000512214905351805 GO:0003743 translation initiation factor activity 10/647 51/18639 0.196078431372549 5.64869533593963 8.36292573569272e-06 0.000600039921535952 GO:0008135 translation factor activity, RNA binding 11/647 83/18639 0.132530120481928 3.81797359453269 0.000135018478973643 0.00894237772279285 GO:0180051 translation factor activity 11/647 84/18639 0.130952380952381 3.77252152793111 0.000150577287788225 0.00926050319897582 GO:0031593 polyubiquitin modification-dependent protein binding 9/647 59/18639 0.152542372881356 4.3944934901632 0.000184227289260595 0.0105746464035582 GO:0032395 MHC class II receptor activity 4/647 10/18639 0.4 11.5233384853168 0.000255577402130112 0.0137532589521266 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/647 18/18639 0.277777777777778 8.00231839258114 0.000291838189625184 0.014780745956899 GO:0016887 ATP hydrolysis activity 29/647 417/18639 0.0695443645083933 2.00345812994118 0.000325805418994369 0.0151819858757607 GO:0051019 mitogen-activated protein kinase binding 6/647 28/18639 0.214285714285714 6.17321704570545 0.000335026401439551 0.0151819858757607 GO:0140104 molecular carrier activity 20/647 249/18639 0.0803212851405622 2.31392339062587 0.000454945704072647 0.0193779493477584 GO:0061650 ubiquitin-like protein conjugating enzyme activity 7/647 41/18639 0.170731707317073 4.9184981339767 0.000472632910920936 0.0193779493477584 GO:0043024 ribosomal small subunit binding 5/647 20/18639 0.25 7.20208655332303 0.000498530393314349 0.0195106667565298 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25/647 349/18639 0.0716332378223496 2.06363511556534 0.000535734291363718 0.0200550967332244 GO:0140313 molecular sequestering activity 8/647 55/18639 0.145454545454545 4.19030490375158 0.00058174445887611 0.0208700824621804 GO:0031369 translation initiation factor binding 6/647 32/18639 0.1875 5.40156491499227 0.000716215885975361 0.0246664751129914 GO:0051087 protein-folding chaperone binding 13/647 134/18639 0.0970149253731343 2.79483955800595 0.000794212700897284 0.026300659056637 GO:0140311 protein sequestering activity 6/647 33/18639 0.181818181818182 5.23788112968948 0.000849988745955575 0.0263622550701224 GO:0003779 actin binding 29/647 443/18639 0.0654627539503386 1.88587367987691 0.000858920609828487 0.0263622550701224 GO:0140597 protein carrier chaperone 16/647 188/18639 0.0851063829787234 2.4517741458121 0.000887927290399011 0.0263622550701224 GO:0032182 ubiquitin-like protein binding 12/647 120/18639 0.1 2.88083462132921 0.000955955130351169 0.0274359122410786 GO:0051082 unfolded protein binding 12/647 121/18639 0.0991735537190083 2.85702607073971 0.00102851279984951 0.0285661135700139 GO:0061631 ubiquitin conjugating enzyme activity 6/647 35/18639 0.171428571428571 4.93857363656436 0.00117454464081073 0.0316025917418136 GO:0140658 ATP-dependent chromatin remodeler activity 14/647 158/18639 0.0886075949367089 2.55263827206386 0.00123982723041821 0.032348219557275 GO:0051020 GTPase binding 22/647 315/18639 0.0698412698412698 2.01201148156326 0.00155993807703605 0.039503137774354 GO:0019843 rRNA binding 8/647 65/18639 0.123076923076923 3.54564261086672 0.00178103121976715 0.0414687599459242 GO:0043531 ADP binding 6/647 38/18639 0.157894736842105 4.54868624420402 0.00182932845565067 0.0414687599459242 GO:0005521 lamin binding 4/647 16/18639 0.25 7.20208655332303 0.00187571849176798 0.0414687599459242 GO:0017070 U6 snRNA binding 4/647 16/18639 0.25 7.20208655332303 0.00187571849176798 0.0414687599459242 GO:0140297 DNA-binding transcription factor binding 30/647 488/18639 0.0614754098360656 1.7710048901614 0.00187837588605232 0.0414687599459242 GO:0015252 proton channel activity 5/647 27/18639 0.185185185185185 5.33487892838743 0.00212367402088906 0.045712083299637 GO:0043130 ubiquitin binding 10/647 100/18639 0.1 2.88083462132921 0.00247745150708109 0.0515064644279463 GO:0046966 nuclear thyroid hormone receptor binding 5/647 28/18639 0.178571428571429 5.14434753808788 0.00251251045989982 0.0515064644279463 GO:0019902 phosphatase binding 15/647 190/18639 0.0789473684210526 2.27434312210201 0.0026562314991167 0.0531864028078949 GO:0042287 MHC protein binding 6/647 41/18639 0.146341463414634 4.2158555434086 0.00272892019369667 0.0532856290699713 GO:0008094 ATP-dependent activity, acting on DNA 16/647 210/18639 0.0761904761904762 2.19492161625083 0.00278496319181034 0.0532856290699713 GO:0003689 DNA clamp loader activity 13/647 160/18639 0.08125 2.34067812982998 0.00389593154807925 0.0729216752803529 GO:0008190 eukaryotic initiation factor 4E binding 3/647 10/18639 0.3 8.64250386398763 0.00416173266652456 0.0731275882832173 GO:0030957 Tat protein binding 3/647 10/18639 0.3 8.64250386398763 0.00416173266652456 0.0731275882832173 GO:1905394 retromer complex binding 3/647 10/18639 0.3 8.64250386398763 0.00416173266652456 0.0731275882832173 GO:0044183 protein folding chaperone 8/647 75/18639 0.106666666666667 3.07289026275116 0.00440319879152734 0.0740545395189681 GO:0019903 protein phosphatase binding 12/647 144/18639 0.0833333333333333 2.40069551777434 0.00444526097614673 0.0740545395189681 GO:0042288 MHC class I protein binding 4/647 20/18639 0.2 5.76166924265842 0.00447251574330586 0.0740545395189681 GO:0140713 histone chaperone activity 13/647 164/18639 0.0792682926829268 2.28358841934633 0.00479957145885471 0.0779703967183755 GO:0030276 clathrin binding 6/647 46/18639 0.130434782608696 3.7576103756468 0.00491281149500551 0.0783320499481434 GO:0003724 RNA helicase activity 8/647 77/18639 0.103896103896104 2.99307493125113 0.00517131178338479 0.0809545353726236 GO:0072542 protein phosphatase activator activity 4/647 21/18639 0.19047619047619 5.48730404062707 0.00537527934217793 0.0826449198859857 GO:0042608 T cell receptor binding 3/647 11/18639 0.272727272727273 7.85682169453421 0.00557590282656 0.0842254795380379 GO:0008186 ATP-dependent activity, acting on RNA 8/647 79/18639 0.10126582278481 2.9173008823587 0.00603782066662098 0.0858404313707224 GO:0038187 pattern recognition receptor activity 6/647 48/18639 0.125 3.60104327666151 0.00607223870653073 0.0858404313707224 GO:0051015 actin filament binding 15/647 209/18639 0.0717703349282297 2.06758465645637 0.00642913281587649 0.0858404313707224 GO:0000510 H3-H4 histone complex chaperone activity 12/647 151/18639 0.0794701986754967 2.28940499708282 0.00646619416365956 0.0858404313707224 GO:0140584 chromatin extrusion motor activity 12/647 151/18639 0.0794701986754967 2.28940499708282 0.00646619416365956 0.0858404313707224 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 12/647 151/18639 0.0794701986754967 2.28940499708282 0.00646619416365956 0.0858404313707224 GO:0140849 ATP-dependent H2AZ histone chaperone activity 12/647 151/18639 0.0794701986754967 2.28940499708282 0.00646619416365956 0.0858404313707224 GO:0005096 GTPase activator activity 18/647 271/18639 0.0664206642066421 1.91346949018176 0.00668704243489826 0.0858404313707224 GO:0017124 SH3 domain binding 10/647 115/18639 0.0869565217391304 2.50507358376453 0.00673378974837866 0.0858404313707224 GO:0015616 DNA translocase activity 12/647 152/18639 0.0789473684210526 2.27434312210201 0.00680614987158704 0.0858404313707224 GO:0140674 ATP-dependent histone chaperone activity 12/647 152/18639 0.0789473684210526 2.27434312210201 0.00680614987158704 0.0858404313707224 GO:0030695 GTPase regulator activity 28/647 489/18639 0.0572597137014315 1.64955765638482 0.00687919833284535 0.0858404313707224 GO:0060589 nucleoside-triphosphatase regulator activity 28/647 490/18639 0.0571428571428571 1.64619121218812 0.00706449471390209 0.0866330834023657 GO:0061775 cohesin loader activity 12/647 153/18639 0.0784313725490196 2.25947813437585 0.00716003902324473 0.0866330834023657 GO:0035259 nuclear glucocorticoid receptor binding 3/647 12/18639 0.25 7.20208655332303 0.00724457840298528 0.0866330834023657 GO:0016779 nucleotidyltransferase activity 11/647 136/18639 0.0808823529411765 2.3300868260751 0.00785629228833036 0.0926612008253759 GO:0001540 amyloid-beta binding 8/647 83/18639 0.0963855421686747 2.77670806875105 0.00809678634797869 0.0937642546409905 GO:0005048 signal sequence binding 6/647 51/18639 0.117647058823529 3.38921720156378 0.00816761800008628 0.0937642546409905 GO:0140375 immune receptor activity 12/647 156/18639 0.0769230769230769 2.2160266317917 0.00830914897420185 0.0941339114051025 GO:0048027 mRNA 5'-UTR binding 4/647 24/18639 0.166666666666667 4.80139103554869 0.00879096543083709 0.0982989770902693 GO:0035325 Toll-like receptor binding 3/647 13/18639 0.230769230769231 6.6480798953751 0.00917775881147979 0.101308337649796 GO:0016860 intramolecular oxidoreductase activity 6/647 53/18639 0.113207547169811 3.26132221282552 0.00982499058699567 0.107079960701307 GO:0019211 phosphatase activator activity 4/647 25/18639 0.16 4.60933539412674 0.0101835391059275 0.107361573926752 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/647 25/18639 0.16 4.60933539412674 0.0101835391059275 0.107361573926752 GO:0031267 small GTPase binding 18/647 283/18639 0.0636042402826855 1.83233297469702 0.0102249118025478 0.107361573926752 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/647 39/18639 0.128205128205128 3.69337771965284 0.0107687115865074 0.111709164770878 GO:0019763 immunoglobulin receptor activity 3/647 14/18639 0.214285714285714 6.17321704570545 0.0113834334372333 0.115307484581857 GO:0071933 Arp2/3 complex binding 3/647 14/18639 0.214285714285714 6.17321704570545 0.0113834334372333 0.115307484581857 GO:0008157 protein phosphatase 1 binding 4/647 26/18639 0.153846153846154 4.4320532635834 0.0117113445160201 0.115901926761992 GO:0050750 low-density lipoprotein particle receptor binding 4/647 26/18639 0.153846153846154 4.4320532635834 0.0117113445160201 0.115901926761992 GO:0140662 ATP-dependent protein folding chaperone 5/647 40/18639 0.125 3.60104327666151 0.0119644229830297 0.117061002140779 GO:0019888 protein phosphatase regulator activity 9/647 107/18639 0.0841121495327103 2.42313192448251 0.0121546654377708 0.117586145414839 GO:0004364 glutathione transferase activity 4/647 27/18639 0.148148148148148 4.26790314270994 0.0133787654716951 0.127990189679217 GO:0140097 catalytic activity, acting on DNA 20/647 336/18639 0.0595238095238095 1.71478251269596 0.0138988458394743 0.13150446448118 GO:0031491 nucleosome binding 7/647 74/18639 0.0945945945945946 2.72511383098709 0.0141925243467187 0.132823515897009 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/647 130/18639 0.0769230769230769 2.2160266317917 0.0152335345071783 0.141033045276134 GO:0031072 heat shock protein binding 10/647 131/18639 0.0763358778625954 2.19911039796123 0.0159989911648836 0.143910941074442 GO:0043022 ribosome binding 9/647 112/18639 0.0803571428571429 2.31495639213955 0.0160209851536833 0.143910941074442 GO:0048156 tau protein binding 5/647 43/18639 0.116279069767442 3.34980769922001 0.0160838526577833 0.143910941074442 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/647 59/18639 0.101694915254237 2.92966232677547 0.0162129631640196 0.143910941074442 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/647 16/18639 0.1875 5.40156491499227 0.0166351338711569 0.146151533296593 GO:0001046 core promoter sequence-specific DNA binding 5/647 44/18639 0.113636363636364 3.27367570605592 0.0176427132470176 0.153000813734236 GO:0140030 modification-dependent protein binding 12/647 173/18639 0.069364161849711 1.9982667893613 0.0177701293535698 0.153000813734236 GO:0051721 protein phosphatase 2A binding 4/647 30/18639 0.133333333333333 3.84111282843895 0.0192568730045816 0.16255066330338 GO:0070566 adenylyltransferase activity 4/647 30/18639 0.133333333333333 3.84111282843895 0.0192568730045816 0.16255066330338 GO:0004386 helicase activity 11/647 155/18639 0.0709677419354839 2.04446327965299 0.0194781148418613 0.162821911445074 GO:1990226 histone methyltransferase binding 3/647 17/18639 0.176470588235294 5.08382580234567 0.0196884956408507 0.162998026411274 GO:0019208 phosphatase regulator activity 9/647 117/18639 0.0769230769230769 2.2160266317917 0.0207206232790425 0.169439130722999 GO:0043021 ribonucleoprotein complex binding 12/647 177/18639 0.0677966101694915 1.95310821785031 0.0208601020402299 0.169439130722999 GO:0016922 nuclear receptor binding 10/647 137/18639 0.072992700729927 2.10279899367096 0.0212034977920071 0.170618799989889 GO:0070325 lipoprotein particle receptor binding 4/647 31/18639 0.129032258064516 3.71720596300543 0.0215189969120182 0.171554225381923 GO:0001618 virus receptor activity 7/647 81/18639 0.0864197530864197 2.4896101665808 0.02233471730649 0.176423776154935 GO:0140272 exogenous protein binding 7/647 82/18639 0.0853658536585366 2.45924906698835 0.0237156625004761 0.185628958299181 GO:0030515 snoRNA binding 4/647 32/18639 0.125 3.60104327666151 0.0239369483612989 0.185673085937643 GO:0005178 integrin binding 11/647 161/18639 0.0683229813664596 1.96827210152928 0.0249742294818794 0.191989389141948 GO:0008574 plus-end-directed microtubule motor activity 3/647 19/18639 0.157894736842105 4.54868624420402 0.0266577209145627 0.201335944802092 GO:0140036 ubiquitin-modified protein reader activity 3/647 19/18639 0.157894736842105 4.54868624420402 0.0266577209145627 0.201335944802092 GO:0016763 pentosyltransferase activity 5/647 49/18639 0.102040816326531 2.93962716462164 0.0269270627092845 0.201601747762556 GO:0030145 manganese ion binding 6/647 68/18639 0.0882352941176471 2.54191290117283 0.0304142638632087 0.225747251605368 GO:0004518 nuclease activity 13/647 209/18639 0.062200956937799 1.79190670226219 0.0309553984739954 0.227799983641966 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/647 21/18639 0.142857142857143 4.1154780304703 0.0347723367511013 0.25372018595507 GO:0017069 snRNA binding 5/647 54/18639 0.0925925925925926 2.66743946419371 0.0388475120036651 0.277026200950822 GO:0033691 sialic acid binding 3/647 22/18639 0.136363636363636 3.92841084726711 0.039253422202091 0.277026200950822 GO:0140035 ubiquitin-like protein reader activity 3/647 22/18639 0.136363636363636 3.92841084726711 0.039253422202091 0.277026200950822 GO:0140517 protein-RNA adaptor activity 3/647 22/18639 0.136363636363636 3.92841084726711 0.039253422202091 0.277026200950822 GO:0003823 antigen binding 11/647 174/18639 0.0632183908045977 1.82121728934605 0.0405948065684792 0.284163645979355 GO:0004602 glutathione peroxidase activity 3/647 23/18639 0.130434782608696 3.7576103756468 0.0440121053245972 0.30038912670297 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/647 10/18639 0.2 5.76166924265842 0.0450060364049746 0.30038912670297 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/647 10/18639 0.2 5.76166924265842 0.0450060364049746 0.30038912670297 GO:0043422 protein kinase B binding 2/647 10/18639 0.2 5.76166924265842 0.0450060364049746 0.30038912670297 GO:0051880 G-quadruplex DNA binding 2/647 10/18639 0.2 5.76166924265842 0.0450060364049746 0.30038912670297 GO:0071723 lipopeptide binding 2/647 10/18639 0.2 5.76166924265842 0.0450060364049746 0.30038912670297 GO:0019787 ubiquitin-like protein transferase activity 24/647 479/18639 0.0501043841336117 1.44342444492487 0.0468100294084106 0.310026425543396 GO:0004601 peroxidase activity 5/647 57/18639 0.087719298245614 2.52704791344668 0.0473249041816979 0.311043835881236 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/647 40/18639 0.1 2.88083462132921 0.0490672215787624 0.320052104388746 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0005536 D-glucose binding 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0008199 ferric iron binding 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0019864 IgG binding 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0032050 clathrin heavy chain binding 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0047676 arachidonate-CoA ligase activity 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0050998 nitric-oxide synthase binding 2/647 11/18639 0.181818181818182 5.23788112968948 0.053768288311289 0.32950111740546 GO:0008139 nuclear localization sequence binding 3/647 25/18639 0.12 3.45700154559505 0.0543428091423639 0.32950111740546 GO:0017025 TBP-class protein binding 3/647 25/18639 0.12 3.45700154559505 0.0543428091423639 0.32950111740546 GO:0019894 kinesin binding 4/647 42/18639 0.0952380952380952 2.74365202031353 0.0569733708746668 0.33830394705578 GO:0035198 miRNA binding 4/647 42/18639 0.0952380952380952 2.74365202031353 0.0569733708746668 0.33830394705578 GO:0051879 Hsp90 protein binding 4/647 42/18639 0.0952380952380952 2.74365202031353 0.0569733708746668 0.33830394705578 GO:0034237 protein kinase A regulatory subunit binding 3/647 26/18639 0.115384615384615 3.32403994768755 0.0599034349631913 0.3415464093222 GO:0004540 RNA nuclease activity 8/647 121/18639 0.0661157024793388 1.90468404715981 0.0599555215911279 0.3415464093222 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/647 61/18639 0.0819672131147541 2.36133985354853 0.0602031953358778 0.3415464093222 GO:0003720 telomerase activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0004032 aldose reductase (NADPH) activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0005049 nuclear export signal receptor activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0016208 AMP binding 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0017166 vinculin binding 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0045295 gamma-catenin binding 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0097677 STAT family protein binding 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/647 12/18639 0.166666666666667 4.80139103554869 0.0630730302929497 0.3415464093222 GO:0003713 transcription coactivator activity 14/647 256/18639 0.0546875 1.57545643353941 0.063472629509483 0.341562087547906 GO:0016755 aminoacyltransferase activity 24/647 496/18639 0.0483870967741935 1.39395223612704 0.0643863172473516 0.344326827018446 GO:0001671 ATPase activator activity 3/647 27/18639 0.111111111111111 3.20092735703246 0.0657190186496285 0.349284413934137 GO:0004842 ubiquitin-protein transferase activity 22/647 449/18639 0.0489977728285078 1.41154480332389 0.0667724057834767 0.352705775334806 GO:0005507 copper ion binding 5/647 63/18639 0.0793650793650794 2.28637668359461 0.067317670301943 0.353417769085201 GO:0004527 exonuclease activity 6/647 84/18639 0.0714285714285714 2.05773901523515 0.0717146092917147 0.366917771076883 GO:0046875 ephrin receptor binding 3/647 28/18639 0.107142857142857 3.08660852285273 0.0717825239307446 0.366917771076883 GO:0097718 disordered domain specific binding 3/647 28/18639 0.107142857142857 3.08660852285273 0.0717825239307446 0.366917771076883 GO:0003964 RNA-directed DNA polymerase activity 2/647 13/18639 0.153846153846154 4.4320532635834 0.0728721705623078 0.366917771076883 GO:0140666 annealing activity 2/647 13/18639 0.153846153846154 4.4320532635834 0.0728721705623078 0.366917771076883 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/647 13/18639 0.153846153846154 4.4320532635834 0.0728721705623078 0.366917771076883 GO:0140852 histone ubiquitin ligase activity 2/647 13/18639 0.153846153846154 4.4320532635834 0.0728721705623078 0.366917771076883 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/647 46/18639 0.0869565217391304 2.50507358376453 0.0746934358090883 0.373901443207122 GO:0000149 SNARE binding 7/647 106/18639 0.0660377358490566 1.90243795748155 0.0758699404318662 0.377595483883449 GO:0106222 lncRNA binding 3/647 29/18639 0.103448275862069 2.98017374620263 0.0780864963184613 0.386393524886179 GO:0001784 phosphotyrosine residue binding 4/647 47/18639 0.0851063829787234 2.4517741458121 0.0795107194188973 0.391192739540975 GO:0035591 signaling adaptor activity 8/647 129/18639 0.062015503875969 1.78656410625067 0.0804363721357081 0.393498388686617 GO:0016757 glycosyltransferase activity 14/647 267/18639 0.052434456928839 1.51054998871195 0.0829468559468759 0.395395428903842 GO:0005545 1-phosphatidylinositol binding 2/647 14/18639 0.142857142857143 4.1154780304703 0.083120293416487 0.395395428903842 GO:0031404 chloride ion binding 2/647 14/18639 0.142857142857143 4.1154780304703 0.083120293416487 0.395395428903842 GO:0032036 myosin heavy chain binding 2/647 14/18639 0.142857142857143 4.1154780304703 0.083120293416487 0.395395428903842 GO:0034236 protein kinase A catalytic subunit binding 2/647 14/18639 0.142857142857143 4.1154780304703 0.083120293416487 0.395395428903842 GO:0004197 cysteine-type endopeptidase activity 6/647 88/18639 0.0681818181818182 1.96420542363355 0.0854417076351963 0.404205001504967 GO:0060590 ATPase regulator activity 4/647 49/18639 0.0816326530612245 2.35170173169732 0.0895941725812529 0.419694731540294 GO:0004857 enzyme inhibitor activity 20/647 416/18639 0.0480769230769231 1.38501664486981 0.0896908601665668 0.419694731540294 GO:0042393 histone binding 13/647 247/18639 0.0526315789473684 1.51622874806801 0.0902655008396172 0.42010052012384 GO:0005164 tumor necrosis factor receptor binding 3/647 31/18639 0.0967741935483871 2.78790447225408 0.0913842772974464 0.422721842605081 GO:0004129 cytochrome-c oxidase activity 2/647 15/18639 0.133333333333333 3.84111282843895 0.093774531867097 0.422721842605081 GO:0004467 long-chain fatty acid-CoA ligase activity 2/647 15/18639 0.133333333333333 3.84111282843895 0.093774531867097 0.422721842605081 GO:0016846 carbon-sulfur lyase activity 2/647 15/18639 0.133333333333333 3.84111282843895 0.093774531867097 0.422721842605081 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/647 15/18639 0.133333333333333 3.84111282843895 0.093774531867097 0.422721842605081 GO:0017081 chloride channel regulator activity 2/647 15/18639 0.133333333333333 3.84111282843895 0.093774531867097 0.422721842605081 GO:0005200 structural constituent of cytoskeleton 7/647 112/18639 0.0625 1.80052163833076 0.0949994097740838 0.426012978205657 GO:0003712 transcription coregulator activity 23/647 495/18639 0.0464646464646465 1.33856962203176 0.0965656873364639 0.42881441996276 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/647 91/18639 0.0659340659340659 1.8994513986786 0.0966202061240132 0.42881441996276 GO:0051059 NF-kappaB binding 3/647 32/18639 0.09375 2.70078245749614 0.0983615871873928 0.432088400858904 GO:0140142 nucleocytoplasmic carrier activity 3/647 32/18639 0.09375 2.70078245749614 0.0983615871873928 0.432088400858904 GO:0052689 carboxylic ester hydrolase activity 6/647 92/18639 0.0652173913043478 1.8788051878234 0.100511597758513 0.43800008684986 GO:0002020 protease binding 8/647 136/18639 0.0588235294117647 1.69460860078189 0.101376683632555 0.43800008684986 GO:0005518 collagen binding 5/647 72/18639 0.0694444444444444 2.00057959814529 0.104760524384416 0.43800008684986 GO:0005149 interleukin-1 receptor binding 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0034450 ubiquitin-ubiquitin ligase activity 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0043023 ribosomal large subunit binding 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0055102 lipase inhibitor activity 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0070411 I-SMAD binding 2/647 16/18639 0.125 3.60104327666151 0.104794445866517 0.43800008684986 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/647 33/18639 0.0909090909090909 2.61894056484474 0.105546462703237 0.439012098490275 GO:0019887 protein kinase regulator activity 13/647 255/18639 0.0509803921568627 1.4686607873443 0.108339315994007 0.448462264763654 GO:0009055 electron transfer activity 7/647 116/18639 0.0603448275862069 1.73843468528487 0.109105940978399 0.448517355818484 GO:0005525 GTP binding 18/647 378/18639 0.0476190476190476 1.37182601015677 0.110141624963183 0.448517355818484 GO:0030246 carbohydrate binding 14/647 280/18639 0.05 1.44041731066461 0.110416073413638 0.448517355818484 GO:0015078 proton transmembrane transporter activity 10/647 185/18639 0.0540540540540541 1.5572079034212 0.11112167149688 0.448517355818484 GO:0070851 growth factor receptor binding 8/647 139/18639 0.0575539568345324 1.65803431443408 0.111202315033277 0.448517355818484 GO:0051018 protein kinase A binding 4/647 53/18639 0.0754716981132075 2.17421480855035 0.111478181353259 0.448517355818484 GO:0003684 damaged DNA binding 5/647 74/18639 0.0675675675675676 1.94650987927649 0.11423550435893 0.457473345362969 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/647 17/18639 0.117647058823529 3.38921720156378 0.116141905896606 0.458707252187971 GO:0005092 GDP-dissociation inhibitor activity 2/647 17/18639 0.117647058823529 3.38921720156378 0.116141905896606 0.458707252187971 GO:0045236 CXCR chemokine receptor binding 2/647 17/18639 0.117647058823529 3.38921720156378 0.116141905896606 0.458707252187971 GO:0008234 cysteine-type peptidase activity 10/647 187/18639 0.053475935828877 1.54055327343808 0.116962431433713 0.459025066590707 GO:0051287 NAD binding 4/647 54/18639 0.0740740740740741 2.13395157135497 0.117288634901226 0.459025066590707 GO:0019003 GDP binding 5/647 75/18639 0.0666666666666667 1.92055641421947 0.119121674724796 0.464089420534159 GO:0005154 epidermal growth factor receptor binding 3/647 35/18639 0.0857142857142857 2.46928681828218 0.120503758012513 0.467359169589072 GO:0015399 primary active transmembrane transporter activity 9/647 166/18639 0.0542168674698795 1.56189828867246 0.124478936949902 0.471924829697455 GO:0042626 ATPase-coupled transmembrane transporter activity 6/647 98/18639 0.0612244897959184 1.76377629877299 0.125539426073153 0.471924829697455 GO:0019207 kinase regulator activity 14/647 287/18639 0.0487804878048781 1.4052851811362 0.127213012431042 0.471924829697455 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/647 18/18639 0.111111111111111 3.20092735703246 0.127780981695176 0.471924829697455 GO:0004706 JUN kinase kinase kinase activity 2/647 18/18639 0.111111111111111 3.20092735703246 0.127780981695176 0.471924829697455 GO:0008409 5'-3' exonuclease activity 2/647 18/18639 0.111111111111111 3.20092735703246 0.127780981695176 0.471924829697455 GO:0035615 clathrin adaptor activity 2/647 18/18639 0.111111111111111 3.20092735703246 0.127780981695176 0.471924829697455 GO:0070628 proteasome binding 2/647 18/18639 0.111111111111111 3.20092735703246 0.127780981695176 0.471924829697455 GO:1990381 ubiquitin-specific protease binding 2/647 18/18639 0.111111111111111 3.20092735703246 0.127780981695176 0.471924829697455 GO:0003697 single-stranded DNA binding 7/647 121/18639 0.0578512396694215 1.66659854126483 0.128211051984518 0.471924829697455 GO:0005484 SNAP receptor activity 3/647 36/18639 0.0833333333333333 2.40069551777434 0.128258316085023 0.471924829697455 GO:0045505 dynein intermediate chain binding 3/647 36/18639 0.0833333333333333 2.40069551777434 0.128258316085023 0.471924829697455 GO:0016504 peptidase activator activity 4/647 57/18639 0.0701754385964912 2.02163833075734 0.135478967055182 0.488902474078509 GO:0043394 proteoglycan binding 3/647 37/18639 0.0810810810810811 2.33581185513179 0.136184785729816 0.488902474078509 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 12/647 243/18639 0.0493827160493827 1.42263438090331 0.140612195326435 0.488902474078509 GO:0008408 3'-5' exonuclease activity 4/647 58/18639 0.0689655172413793 1.98678249746842 0.141782939971575 0.488902474078509 GO:0061980 regulatory RNA binding 4/647 58/18639 0.0689655172413793 1.98678249746842 0.141782939971575 0.488902474078509 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/647 38/18639 0.0789473684210526 2.27434312210201 0.14427410185497 0.488902474078509 GO:0042162 telomeric DNA binding 3/647 38/18639 0.0789473684210526 2.27434312210201 0.14427410185497 0.488902474078509 GO:0004676 3-phosphoinositide-dependent protein kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0004711 ribosomal protein S6 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0035175 histone H3S10 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0035979 histone H2AXS139 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0044022 histone H3S28 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0044023 histone H4S1 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0044024 histone H2AS1 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0044025 histone H2BS14 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0072354 histone H3T3 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0072371 histone H2AS121 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0072518 Rho-dependent protein serine/threonine kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0140823 histone H2BS36 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0140855 histone H3S57 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0140995 histone H2A kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0140997 histone H4 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0140998 histone H2B kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:1990244 histone H2AT120 kinase activity 12/647 245/18639 0.0489795918367347 1.41102103901839 0.146500392929449 0.488902474078509 GO:0045309 protein phosphorylated amino acid binding 4/647 59/18639 0.0677966101694915 1.95310821785031 0.148200716329738 0.489990017006495 GO:0004677 DNA-dependent protein kinase activity 12/647 246/18639 0.0487804878048781 1.4052851811362 0.14949284292224 0.489990017006495 GO:0140857 histone H3T45 kinase activity 12/647 246/18639 0.0487804878048781 1.4052851811362 0.14949284292224 0.489990017006495 GO:0001614 purinergic nucleotide receptor activity 2/647 20/18639 0.1 2.88083462132921 0.151800622436149 0.489990017006495 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/647 20/18639 0.1 2.88083462132921 0.151800622436149 0.489990017006495 GO:0016502 nucleotide receptor activity 2/647 20/18639 0.1 2.88083462132921 0.151800622436149 0.489990017006495 GO:0016505 peptidase activator activity involved in apoptotic process 2/647 20/18639 0.1 2.88083462132921 0.151800622436149 0.489990017006495 GO:0061659 ubiquitin-like protein ligase activity 17/647 372/18639 0.0456989247311828 1.31651044523109 0.152227205300506 0.489990017006495 GO:0035402 histone H3T11 kinase activity 12/647 247/18639 0.048582995951417 1.39959576744739 0.152517217837097 0.489990017006495 GO:0035403 histone H3T6 kinase activity 12/647 247/18639 0.048582995951417 1.39959576744739 0.152517217837097 0.489990017006495 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/647 60/18639 0.0666666666666667 1.92055641421947 0.154728303229674 0.49524560996561 GO:0004679 AMP-activated protein kinase activity 12/647 248/18639 0.0483870967741935 1.39395223612704 0.155573273174507 0.496105882234261 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 7/647 128/18639 0.0546875 1.57545643353941 0.157554549492834 0.499770575904491 GO:0019001 guanyl nucleotide binding 18/647 400/18639 0.045 1.29637557959815 0.158463841140448 0.499770575904491 GO:0032561 guanyl ribonucleotide binding 18/647 400/18639 0.045 1.29637557959815 0.158463841140448 0.499770575904491 GO:0004532 RNA exonuclease activity 3/647 40/18639 0.075 2.16062596599691 0.16090503450221 0.503378172463064 GO:0030331 nuclear estrogen receptor binding 3/647 40/18639 0.075 2.16062596599691 0.16090503450221 0.503378172463064 GO:0019905 syntaxin binding 4/647 61/18639 0.0655737704918033 1.88907188283883 0.161361644134501 0.503378172463064 GO:0061134 peptidase regulator activity 11/647 226/18639 0.0486725663716814 1.40217614312484 0.164092308187378 0.504667122252371 GO:0008373 sialyltransferase activity 2/647 21/18639 0.0952380952380952 2.74365202031353 0.164119389350364 0.504667122252371 GO:0070182 DNA polymerase binding 2/647 21/18639 0.0952380952380952 2.74365202031353 0.164119389350364 0.504667122252371 GO:0140312 cargo adaptor activity 2/647 21/18639 0.0952380952380952 2.74365202031353 0.164119389350364 0.504667122252371 GO:0004860 protein kinase inhibitor activity 5/647 84/18639 0.0595238095238095 1.71478251269596 0.167214627276106 0.512355139091557 GO:0061630 ubiquitin protein ligase activity 16/647 353/18639 0.0453257790368272 1.3057607348801 0.168689959063546 0.515042747353592 GO:0001217 DNA-binding transcription repressor activity 13/647 278/18639 0.0467625899280576 1.34715288047769 0.171232184655866 0.520957282645585 GO:0004843 cysteine-type deubiquitinase activity 6/647 108/18639 0.0555555555555556 1.60046367851623 0.17316280428521 0.524975966512555 GO:0016853 isomerase activity 9/647 180/18639 0.05 1.44041731066461 0.174966415635048 0.527978312507396 GO:0008093 cytoskeletal anchor activity 2/647 22/18639 0.0909090909090909 2.61894056484474 0.176605986065192 0.527978312507396 GO:0034062 5'-3' RNA polymerase activity 2/647 22/18639 0.0909090909090909 2.61894056484474 0.176605986065192 0.527978312507396 GO:0097747 RNA polymerase activity 2/647 22/18639 0.0909090909090909 2.61894056484474 0.176605986065192 0.527978312507396 GO:0005085 guanyl-nucleotide exchange factor activity 11/647 230/18639 0.0478260869565217 1.37779047107049 0.177690513543088 0.52871046945056 GO:0048487 beta-tubulin binding 3/647 42/18639 0.0714285714285714 2.05773901523515 0.178079019907854 0.52871046945056 GO:0016209 antioxidant activity 5/647 86/18639 0.0581395348837209 1.67490384961001 0.178814419442937 0.52906946783632 GO:1902936 phosphatidylinositol bisphosphate binding 6/647 111/18639 0.0540540540540541 1.5572079034212 0.18872802519051 0.552306617704606 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/647 23/18639 0.0869565217391304 2.50507358376453 0.189233974707153 0.552306617704606 GO:0140103 catalytic activity, acting on a glycoprotein 2/647 23/18639 0.0869565217391304 2.50507358376453 0.189233974707153 0.552306617704606 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/647 23/18639 0.0869565217391304 2.50507358376453 0.189233974707153 0.552306617704606 GO:0001216 DNA-binding transcription activator activity 21/647 491/18639 0.0427698574338086 1.2321288604463 0.191075173295562 0.554935839827371 GO:0140098 catalytic activity, acting on RNA 17/647 387/18639 0.0439276485788114 1.26548290859423 0.191423861125121 0.554935839827371 GO:0140789 histone phosphatase activity 7/647 136/18639 0.0514705882352941 1.48278252568415 0.194445215243889 0.555428777920202 GO:1901981 phosphatidylinositol phosphate binding 9/647 185/18639 0.0486486486486487 1.40148711307908 0.194981966661126 0.555428777920202 GO:0001223 transcription coactivator binding 3/647 44/18639 0.0681818181818182 1.96420542363355 0.195725052423354 0.555428777920202 GO:0030547 signaling receptor inhibitor activity 3/647 44/18639 0.0681818181818182 1.96420542363355 0.195725052423354 0.555428777920202 GO:0008235 metalloexopeptidase activity 4/647 66/18639 0.0606060606060606 1.74596037656316 0.195969388256858 0.555428777920202 GO:0003727 single-stranded RNA binding 5/647 89/18639 0.0561797752808989 1.61844641647709 0.196754677428178 0.555428777920202 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 5/647 89/18639 0.0561797752808989 1.61844641647709 0.196754677428178 0.555428777920202 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 5/647 89/18639 0.0561797752808989 1.61844641647709 0.196754677428178 0.555428777920202 GO:0019957 C-C chemokine binding 2/647 24/18639 0.0833333333333333 2.40069551777434 0.201978545431622 0.55882379818919 GO:0035035 histone acetyltransferase binding 2/647 24/18639 0.0833333333333333 2.40069551777434 0.201978545431622 0.55882379818919 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/647 24/18639 0.0833333333333333 2.40069551777434 0.201978545431622 0.55882379818919 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/647 24/18639 0.0833333333333333 2.40069551777434 0.201978545431622 0.55882379818919 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/647 24/18639 0.0833333333333333 2.40069551777434 0.201978545431622 0.55882379818919 GO:0019210 kinase inhibitor activity 5/647 90/18639 0.0555555555555556 1.60046367851623 0.202869012312719 0.55882379818919 GO:0140793 histone H2AXY142 phosphatase activity 5/647 90/18639 0.0555555555555556 1.60046367851623 0.202869012312719 0.55882379818919 GO:0050840 extracellular matrix binding 4/647 67/18639 0.0597014925373134 1.7199012664652 0.203149650212795 0.55882379818919 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/647 45/18639 0.0666666666666667 1.92055641421947 0.204703340911664 0.561304383837397 GO:0001221 transcription coregulator binding 6/647 115/18639 0.0521739130434783 1.50304415025872 0.210277611606205 0.571481929736661 GO:0101005 deubiquitinase activity 6/647 115/18639 0.0521739130434783 1.50304415025872 0.210277611606205 0.571481929736661 GO:0003777 microtubule motor activity 4/647 68/18639 0.0588235294117647 1.69460860078189 0.210406238939049 0.571481929736661 GO:0004709 MAP kinase kinase kinase activity 2/647 25/18639 0.08 2.30466769706337 0.214816435543732 0.577990471884853 GO:0015645 fatty acid ligase activity 2/647 25/18639 0.08 2.30466769706337 0.214816435543732 0.577990471884853 GO:0120515 fatty acid-CoA ligase activity 2/647 25/18639 0.08 2.30466769706337 0.214816435543732 0.577990471884853 GO:0051219 phosphoprotein binding 5/647 93/18639 0.0537634408602151 1.54883581791893 0.221579318225807 0.588804681065485 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 12/647 268/18639 0.0447761194029851 1.2899259498489 0.222887722496327 0.588804681065485 GO:0043495 protein-membrane adaptor activity 3/647 47/18639 0.0638297872340425 1.83883060935907 0.222928100315485 0.588804681065485 GO:0022853 active monoatomic ion transmembrane transporter activity 6/647 118/18639 0.0508474576271186 1.46483116338773 0.22697826025498 0.588804681065485 GO:0008143 poly(A) binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0008198 ferrous iron binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0019865 immunoglobulin binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0030247 polysaccharide binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0030507 spectrin binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0052742 phosphatidylinositol kinase activity 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0070006 metalloaminopeptidase activity 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0070412 R-SMAD binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0097602 cullin family protein binding 2/647 26/18639 0.0769230769230769 2.2160266317917 0.227725852258777 0.588804681065485 GO:0001664 G protein-coupled receptor binding 13/647 297/18639 0.0437710437710438 1.26097138307339 0.234212115781394 0.602405464113011 GO:0019955 cytokine binding 7/647 144/18639 0.0486111111111111 1.4004057187017 0.234385401251869 0.602405464113011 GO:0005044 scavenger receptor activity 2/647 27/18639 0.0740740740740741 2.13395157135497 0.240686398947509 0.609657991202635 GO:0008320 protein transmembrane transporter activity 2/647 27/18639 0.0740740740740741 2.13395157135497 0.240686398947509 0.609657991202635 GO:0016405 CoA-ligase activity 2/647 27/18639 0.0740740740740741 2.13395157135497 0.240686398947509 0.609657991202635 GO:0035255 ionotropic glutamate receptor binding 2/647 27/18639 0.0740740740740741 2.13395157135497 0.240686398947509 0.609657991202635 GO:0001222 transcription corepressor binding 3/647 49/18639 0.0612244897959184 1.76377629877299 0.24145572009303 0.609657991202635 GO:0035254 glutamate receptor binding 3/647 49/18639 0.0612244897959184 1.76377629877299 0.24145572009303 0.609657991202635 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 20/647 484/18639 0.0413223140495868 1.19042752947488 0.242170992846842 0.609676096026698 GO:0005126 cytokine receptor binding 12/647 275/18639 0.0436363636363636 1.25709147112547 0.248917868561526 0.624834649654443 GO:0032813 tumor necrosis factor receptor superfamily binding 3/647 50/18639 0.06 1.72850077279753 0.250813212676481 0.627762139867588 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/647 28/18639 0.0714285714285714 2.05773901523515 0.253679004718029 0.631647707106612 GO:0004725 protein tyrosine phosphatase activity 5/647 98/18639 0.0510204081632653 1.46981358231082 0.253832876491159 0.631647707106612 GO:0003924 GTPase activity 14/647 331/18639 0.0422960725075529 1.21847990026009 0.261825605228944 0.646410343832466 GO:0004721 phosphoprotein phosphatase activity 8/647 175/18639 0.0457142857142857 1.3169529697505 0.263403418870408 0.646410343832466 GO:0003785 actin monomer binding 2/647 29/18639 0.0689655172413793 1.98678249746842 0.266685857192071 0.646410343832466 GO:0043236 laminin binding 2/647 29/18639 0.0689655172413793 1.98678249746842 0.266685857192071 0.646410343832466 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/647 29/18639 0.0689655172413793 1.98678249746842 0.266685857192071 0.646410343832466 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/647 52/18639 0.0576923076923077 1.66201997384378 0.269677363414848 0.646410343832466 GO:0140296 general transcription initiation factor binding 3/647 53/18639 0.0566037735849057 1.63066110641276 0.279169314338544 0.646410343832466 GO:0019783 ubiquitin-like protein peptidase activity 6/647 127/18639 0.047244094488189 1.36102423054923 0.279345965095949 0.646410343832466 GO:0042826 histone deacetylase binding 6/647 127/18639 0.047244094488189 1.36102423054923 0.279345965095949 0.646410343832466 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/647 30/18639 0.0666666666666667 1.92055641421947 0.279690338339281 0.646410343832466 GO:0016769 transferase activity, transferring nitrogenous groups 2/647 30/18639 0.0666666666666667 1.92055641421947 0.279690338339281 0.646410343832466 GO:0032452 histone demethylase activity 2/647 30/18639 0.0666666666666667 1.92055641421947 0.279690338339281 0.646410343832466 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/647 30/18639 0.0666666666666667 1.92055641421947 0.279690338339281 0.646410343832466 GO:0048019 receptor antagonist activity 2/647 30/18639 0.0666666666666667 1.92055641421947 0.279690338339281 0.646410343832466 GO:0008238 exopeptidase activity 5/647 102/18639 0.0490196078431373 1.41217383398491 0.280411807527891 0.646410343832466 GO:0035091 phosphatidylinositol binding 12/647 284/18639 0.0422535211267606 1.21725406535037 0.283900712878585 0.646410343832466 GO:0031490 chromatin DNA binding 6/647 128/18639 0.046875 1.35039122874807 0.285335706846922 0.646410343832466 GO:0004722 protein serine/threonine phosphatase activity 5/647 103/18639 0.0485436893203883 1.39846340841224 0.287142820009588 0.646410343832466 GO:0015485 cholesterol binding 3/647 54/18639 0.0555555555555556 1.60046367851623 0.288691707246622 0.646410343832466 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/647 54/18639 0.0555555555555556 1.60046367851623 0.288691707246622 0.646410343832466 GO:0016878 acid-thiol ligase activity 2/647 31/18639 0.0645161290322581 1.85860298150272 0.292676963238719 0.646410343832466 GO:0140457 protein demethylase activity 2/647 31/18639 0.0645161290322581 1.85860298150272 0.292676963238719 0.646410343832466 GO:0016835 carbon-oxygen lyase activity 4/647 79/18639 0.0506329113924051 1.45865044117935 0.294063228047423 0.646410343832466 GO:0046332 SMAD binding 4/647 79/18639 0.0506329113924051 1.45865044117935 0.294063228047423 0.646410343832466 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0004955 prostaglandin receptor activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0005031 tumor necrosis factor receptor activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0008140 cAMP response element binding protein binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0008239 dipeptidyl-peptidase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0015203 polyamine transmembrane transporter activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0015643 toxic substance binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0032052 bile acid binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0042975 peroxisome proliferator activated receptor binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0043295 glutathione binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0045322 unmethylated CpG binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0047429 nucleoside triphosphate diphosphatase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0051864 histone H3K36 demethylase activity 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0070097 delta-catenin binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0098505 G-rich strand telomeric DNA binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:1990763 arrestin family protein binding 1/647 10/18639 0.1 2.88083462132921 0.297687136656879 0.646410343832466 GO:0008378 galactosyltransferase activity 2/647 32/18639 0.0625 1.80052163833076 0.30563132164214 0.646410343832466 GO:0022884 macromolecule transmembrane transporter activity 2/647 32/18639 0.0625 1.80052163833076 0.30563132164214 0.646410343832466 GO:0070717 poly-purine tract binding 2/647 32/18639 0.0625 1.80052163833076 0.30563132164214 0.646410343832466 GO:0061135 endopeptidase regulator activity 8/647 184/18639 0.0434782608695652 1.25253679188227 0.308728066291592 0.646410343832466 GO:0033192 calmodulin-dependent protein phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0140791 histone H2AXS140 phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:1990439 MAP kinase serine/threonine phosphatase activity 4/647 81/18639 0.0493827160493827 1.42263438090331 0.309780944127625 0.646410343832466 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 4/647 82/18639 0.0487804878048781 1.4052851811362 0.317670960388988 0.646410343832466 GO:0033549 MAP kinase phosphatase activity 4/647 82/18639 0.0487804878048781 1.4052851811362 0.317670960388988 0.646410343832466 GO:0019239 deaminase activity 2/647 33/18639 0.0606060606060606 1.74596037656316 0.318540022218843 0.646410343832466 GO:0019956 chemokine binding 2/647 33/18639 0.0606060606060606 1.74596037656316 0.318540022218843 0.646410343832466 GO:0030296 protein tyrosine kinase activator activity 2/647 33/18639 0.0606060606060606 1.74596037656316 0.318540022218843 0.646410343832466 GO:0000099 sulfur amino acid transmembrane transporter activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0004954 prostanoid receptor activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0005114 type II transforming growth factor beta receptor binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0005225 volume-sensitive anion channel activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0008432 JUN kinase binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0008503 benzodiazepine receptor activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0015173 aromatic amino acid transmembrane transporter activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0032794 GTPase activating protein binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0034511 U3 snoRNA binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0048185 activin binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0050786 RAGE receptor binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0140537 transcription regulator activator activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:1900750 oligopeptide binding 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:1990948 ubiquitin ligase inhibitor activity 1/647 11/18639 0.0909090909090909 2.61894056484474 0.322079021491438 0.646410343832466 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4/647 83/18639 0.0481927710843374 1.38835403437552 0.325576826616477 0.649212886187759 GO:0004866 endopeptidase inhibitor activity 7/647 161/18639 0.0434782608695652 1.25253679188227 0.326455838353099 0.649212886187759 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/647 34/18639 0.0588235294117647 1.69460860078189 0.331390639366739 0.649212886187759 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/647 34/18639 0.0588235294117647 1.69460860078189 0.331390639366739 0.649212886187759 GO:0017018 myosin phosphatase activity 4/647 84/18639 0.0476190476190476 1.37182601015677 0.333494936583495 0.649212886187759 GO:0051117 ATPase binding 4/647 84/18639 0.0476190476190476 1.37182601015677 0.333494936583495 0.649212886187759 GO:0044325 transmembrane transporter binding 6/647 136/18639 0.0441176470588235 1.27095645058642 0.334099388545374 0.649212886187759 GO:0001786 phosphatidylserine binding 3/647 59/18639 0.0508474576271186 1.46483116338773 0.336527679995598 0.649212886187759 GO:0070063 RNA polymerase binding 3/647 59/18639 0.0508474576271186 1.46483116338773 0.336527679995598 0.649212886187759 GO:0000175 3'-5'-RNA exonuclease activity 2/647 35/18639 0.0571428571428571 1.64619121218812 0.344171662479116 0.649212886187759 GO:0034061 DNA polymerase activity 2/647 35/18639 0.0571428571428571 1.64619121218812 0.344171662479116 0.649212886187759 GO:0000340 RNA 7-methylguanosine cap binding 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0004000 adenosine deaminase activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0004300 enoyl-CoA hydratase activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0004859 phospholipase inhibitor activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0004875 complement receptor activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0005025 transforming growth factor beta receptor activity, type I 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0005026 transforming growth factor beta receptor activity, type II 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0005247 voltage-gated chloride channel activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0008603 cAMP-dependent protein kinase regulator activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0016361 activin receptor activity, type I 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0016362 activin receptor activity, type II 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0017002 activin receptor activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0035497 cAMP response element binding 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0043047 single-stranded telomeric DNA binding 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0070008 serine-type exopeptidase activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:1990459 transferrin receptor binding 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:1990817 poly(A) RNA polymerase activity 1/647 12/18639 0.0833333333333333 2.40069551777434 0.3456250206913 0.649212886187759 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/647 60/18639 0.05 1.44041731066461 0.346096068246436 0.649212886187759 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/647 86/18639 0.0465116279069767 1.33992307968801 0.34935382030828 0.65389921583789 GO:0033218 amide binding 10/647 247/18639 0.0404858299595142 1.16632980620616 0.355228984158887 0.653924040849411 GO:0004033 aldo-keto reductase (NADPH) activity 2/647 36/18639 0.0555555555555556 1.60046367851623 0.356872447561122 0.653924040849411 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/647 36/18639 0.0555555555555556 1.60046367851623 0.356872447561122 0.653924040849411 GO:0055106 ubiquitin-protein transferase regulator activity 2/647 36/18639 0.0555555555555556 1.60046367851623 0.356872447561122 0.653924040849411 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/647 36/18639 0.0555555555555556 1.60046367851623 0.356872447561122 0.653924040849411 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/647 36/18639 0.0555555555555556 1.60046367851623 0.356872447561122 0.653924040849411 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/647 36/18639 0.0555555555555556 1.60046367851623 0.356872447561122 0.653924040849411 GO:0016874 ligase activity 7/647 167/18639 0.0419161676646707 1.20753547001823 0.360345483479937 0.653924040849411 GO:0015631 tubulin binding 15/647 385/18639 0.038961038961039 1.12240309921917 0.360559266524619 0.653924040849411 GO:0008017 microtubule binding 11/647 276/18639 0.0398550724637681 1.14815872589208 0.36326939163144 0.653924040849411 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/647 88/18639 0.0454545454545455 1.30947028242237 0.365220218679663 0.653924040849411 GO:0005543 phospholipid binding 19/647 497/18639 0.0382293762575453 1.10132510674557 0.365867576874205 0.653924040849411 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0004535 poly(A)-specific ribonuclease activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0005035 death receptor activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0019104 DNA N-glycosylase activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0039706 co-receptor binding 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0045159 myosin II binding 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0046975 histone H3K36 methyltransferase activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0070123 transforming growth factor beta receptor activity, type III 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0089720 caspase binding 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0097157 pre-mRNA intronic binding 1/647 13/18639 0.0769230769230769 2.2160266317917 0.368354424868716 0.653924040849411 GO:0030414 peptidase inhibitor activity 7/647 169/18639 0.0414201183431953 1.1932451094263 0.371716057971614 0.658534003937366 GO:0106310 protein serine kinase activity 14/647 361/18639 0.038781163434903 1.11722118278695 0.374076884230782 0.66135564131972 GO:0016758 hexosyltransferase activity 8/647 197/18639 0.0406091370558376 1.1698820797276 0.376602905460285 0.662809537966304 GO:0072341 modified amino acid binding 4/647 91/18639 0.043956043956044 1.2663009324524 0.388977005572191 0.662809537966304 GO:0004705 JUN kinase activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0005161 platelet-derived growth factor receptor binding 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0008191 metalloendopeptidase inhibitor activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0008474 palmitoyl-(protein) hydrolase activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0008494 translation activator activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0008559 ABC-type xenobiotic transporter activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0015926 glucosidase activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0016530 metallochaperone activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0042043 neurexin family protein binding 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0044548 S100 protein binding 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0046030 inositol trisphosphate phosphatase activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0098599 palmitoyl hydrolase activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0098821 BMP receptor activity 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0098847 sequence-specific single stranded DNA binding 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:1901612 cardiolipin binding 1/647 14/18639 0.0714285714285714 2.05773901523515 0.390295511903503 0.662809537966304 GO:0016829 lyase activity 8/647 200/18639 0.04 1.15233384853168 0.392463631078139 0.665179500705272 GO:0038024 cargo receptor activity 3/647 65/18639 0.0461538461538462 1.32961597907502 0.393635898100162 0.665838277952789 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/647 39/18639 0.0512820512820513 1.47735108786113 0.394398979972035 0.665838277952789 GO:0004177 aminopeptidase activity 2/647 40/18639 0.05 1.44041731066461 0.406688134996762 0.666458733386787 GO:0032451 demethylase activity 2/647 40/18639 0.05 1.44041731066461 0.406688134996762 0.666458733386787 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/647 40/18639 0.05 1.44041731066461 0.406688134996762 0.666458733386787 GO:0000774 adenyl-nucleotide exchange factor activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0004559 alpha-mannosidase activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0004953 icosanoid receptor activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0005041 low-density lipoprotein particle receptor activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0005523 tropomyosin binding 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0015929 hexosaminidase activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0031005 filamin binding 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0033130 acetylcholine receptor binding 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0042809 nuclear vitamin D receptor binding 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0047372 monoacylglycerol lipase activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0048531 beta-1,3-galactosyltransferase activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0050700 CARD domain binding 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0050780 dopamine receptor binding 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0061578 K63-linked deubiquitinase activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0140776 protein-containing complex destabilizing activity 1/647 15/18639 0.0666666666666667 1.92055641421947 0.411475581906103 0.666458733386787 GO:0003714 transcription corepressor activity 8/647 204/18639 0.0392156862745098 1.12973906718793 0.41363335951697 0.666458733386787 GO:0001530 lipopolysaccharide binding 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0001727 lipid kinase activity 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0017080 sodium channel regulator activity 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0042169 SH2 domain binding 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0140318 protein transporter activity 2/647 41/18639 0.0487804878048781 1.4052851811362 0.418855289796316 0.666458733386787 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/647 68/18639 0.0441176470588235 1.27095645058642 0.421742510858097 0.666458733386787 GO:0032934 sterol binding 3/647 68/18639 0.0441176470588235 1.27095645058642 0.421742510858097 0.666458733386787 GO:0140223 general transcription initiation factor activity 3/647 68/18639 0.0441176470588235 1.27095645058642 0.421742510858097 0.666458733386787 GO:1990841 promoter-specific chromatin binding 3/647 68/18639 0.0441176470588235 1.27095645058642 0.421742510858097 0.666458733386787 GO:0005125 cytokine activity 9/647 234/18639 0.0384615384615385 1.10801331589585 0.424934966183125 0.666458733386787 GO:0003730 mRNA 3'-UTR binding 10/647 262/18639 0.0381679389312977 1.09955519898062 0.425315400113972 0.666458733386787 GO:0004896 cytokine receptor activity 4/647 96/18639 0.0416666666666667 1.20034775888717 0.428256728027251 0.666458733386787 GO:0004520 DNA endonuclease activity 2/647 42/18639 0.0476190476190476 1.37182601015677 0.430894103290739 0.666458733386787 GO:0016859 cis-trans isomerase activity 2/647 42/18639 0.0476190476190476 1.37182601015677 0.430894103290739 0.666458733386787 GO:0004707 MAP kinase activity 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0005024 transforming growth factor beta receptor activity 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0005159 insulin-like growth factor receptor binding 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0008296 3'-5'-DNA exonuclease activity 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0015923 mannosidase activity 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0016722 oxidoreductase activity, acting on metal ions 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0022858 alanine transmembrane transporter activity 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0030275 LRR domain binding 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0097027 ubiquitin-protein transferase activator activity 1/647 16/18639 0.0625 1.80052163833076 0.431920990975409 0.666458733386787 GO:0003774 cytoskeletal motor activity 6/647 153/18639 0.0392156862745098 1.12973906718793 0.439579905587008 0.675133394523664 GO:0097110 scaffold protein binding 3/647 70/18639 0.0428571428571429 1.23464340914109 0.440234279504437 0.675133394523664 GO:0008200 ion channel inhibitor activity 2/647 43/18639 0.0465116279069767 1.33992307968801 0.44279882009371 0.675133394523664 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/647 43/18639 0.0465116279069767 1.33992307968801 0.44279882009371 0.675133394523664 GO:0004550 nucleoside diphosphate kinase activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0004659 prenyltransferase activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0017110 nucleoside diphosphate phosphatase activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0030169 low-density lipoprotein particle binding 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0030548 acetylcholine receptor regulator activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0031489 myosin V binding 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0032183 SUMO binding 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0032977 membrane insertase activity 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0046965 nuclear retinoid X receptor binding 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0051787 misfolded protein binding 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0070403 NAD+ binding 1/647 17/18639 0.0588235294117647 1.69460860078189 0.451657183792835 0.675133394523664 GO:0016248 channel inhibitor activity 2/647 44/18639 0.0454545454545455 1.30947028242237 0.454564237601822 0.678301228033222 GO:0008237 metallopeptidase activity 7/647 184/18639 0.0380434782608696 1.09596969289698 0.456975542893307 0.680626881091168 GO:0141003 histone H2AX kinase activity 13/647 354/18639 0.0367231638418079 1.05793361800225 0.457800884296479 0.680626881091168 GO:0042379 chemokine receptor binding 3/647 72/18639 0.0416666666666667 1.20034775888717 0.458494298528313 0.680626881091168 GO:0008009 chemokine activity 2/647 45/18639 0.0444444444444444 1.28037094281298 0.466185674657178 0.68228991970507 GO:0141110 transporter inhibitor activity 2/647 45/18639 0.0444444444444444 1.28037094281298 0.466185674657178 0.68228991970507 GO:0140996 histone H3 kinase activity 13/647 357/18639 0.0364145658263305 1.04904341953165 0.469982075898299 0.68228991970507 GO:0000400 four-way junction DNA binding 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0003746 translation elongation factor activity 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0008308 voltage-gated monoatomic anion channel activity 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0017128 phospholipid scramblase activity 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0030228 lipoprotein particle receptor activity 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0098641 cadherin binding involved in cell-cell adhesion 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0099602 neurotransmitter receptor regulator activity 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:1901611 phosphatidylglycerol binding 1/647 18/18639 0.0555555555555556 1.60046367851623 0.470708725092696 0.68228991970507 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/647 130/18639 0.0384615384615385 1.10801331589585 0.472318044135992 0.683471993279141 GO:0035064 methylated histone binding 3/647 74/18639 0.0405405405405405 1.1679059275659 0.476495898991255 0.687207653319046 GO:0048029 monosaccharide binding 3/647 74/18639 0.0405405405405405 1.1679059275659 0.476495898991255 0.687207653319046 GO:0004180 carboxypeptidase activity 2/647 46/18639 0.0434782608695652 1.25253679188227 0.477658941713996 0.687733024775503 GO:0035173 histone kinase activity 13/647 360/18639 0.0361111111111111 1.04030139103555 0.482123037521375 0.693001561445582 GO:0140359 ABC-type transporter activity 2/647 47/18639 0.0425531914893617 1.22588707290605 0.488980312442818 0.694908454077513 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/647 19/18639 0.0526315789473684 1.51622874806801 0.489099330047588 0.694908454077513 GO:0008301 DNA binding, bending 1/647 19/18639 0.0526315789473684 1.51622874806801 0.489099330047588 0.694908454077513 GO:0042800 histone H3K4 methyltransferase activity 1/647 19/18639 0.0526315789473684 1.51622874806801 0.489099330047588 0.694908454077513 GO:0042834 peptidoglycan binding 1/647 19/18639 0.0526315789473684 1.51622874806801 0.489099330047588 0.694908454077513 GO:0050145 nucleoside monophosphate kinase activity 1/647 19/18639 0.0526315789473684 1.51622874806801 0.489099330047588 0.694908454077513 GO:0070003 threonine-type peptidase activity 1/647 19/18639 0.0526315789473684 1.51622874806801 0.489099330047588 0.694908454077513 GO:0017022 myosin binding 3/647 76/18639 0.0394736842105263 1.137171561051 0.494215217676748 0.698988354457719 GO:0140034 methylation-dependent protein binding 3/647 76/18639 0.0394736842105263 1.137171561051 0.494215217676748 0.698988354457719 GO:0008083 growth factor activity 6/647 162/18639 0.037037037037037 1.06697578567749 0.49440639705546 0.698988354457719 GO:0032266 phosphatidylinositol-3-phosphate binding 2/647 48/18639 0.0416666666666667 1.20034775888717 0.500146496708724 0.704789089470068 GO:0140693 molecular condensate scaffold activity 2/647 48/18639 0.0416666666666667 1.20034775888717 0.500146496708724 0.704789089470068 GO:0008013 beta-catenin binding 4/647 106/18639 0.0377358490566038 1.08710740427517 0.504465293080831 0.707292512795525 GO:0000339 RNA cap binding 1/647 20/18639 0.05 1.44041731066461 0.506851893606085 0.707292512795525 GO:0016004 phospholipase activator activity 1/647 20/18639 0.05 1.44041731066461 0.506851893606085 0.707292512795525 GO:0030742 GTP-dependent protein binding 1/647 20/18639 0.05 1.44041731066461 0.506851893606085 0.707292512795525 GO:0052745 inositol phosphate phosphatase activity 1/647 20/18639 0.05 1.44041731066461 0.506851893606085 0.707292512795525 GO:0061608 nuclear import signal receptor activity 1/647 20/18639 0.05 1.44041731066461 0.506851893606085 0.707292512795525 GO:0005496 steroid binding 4/647 108/18639 0.037037037037037 1.06697578567749 0.519182038932947 0.72332643288231 GO:0010314 phosphatidylinositol-5-phosphate binding 1/647 21/18639 0.0476190476190476 1.37182601015677 0.52398851881887 0.726496158942105 GO:0035613 RNA stem-loop binding 1/647 21/18639 0.0476190476190476 1.37182601015677 0.52398851881887 0.726496158942105 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/647 21/18639 0.0476190476190476 1.37182601015677 0.52398851881887 0.726496158942105 GO:0015101 organic cation transmembrane transporter activity 3/647 81/18639 0.037037037037037 1.06697578567749 0.537145729497784 0.738736917369578 GO:0004407 histone deacetylase activity 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0008970 phospholipase A1 activity 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0031683 G-protein beta/gamma-subunit complex binding 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0033558 protein lysine deacetylase activity 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0061133 endopeptidase activator activity 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0070034 telomerase RNA binding 1/647 22/18639 0.0454545454545455 1.30947028242237 0.540530544188093 0.738736917369578 GO:0004674 protein serine/threonine kinase activity 15/647 433/18639 0.0346420323325635 0.997979660968549 0.540539207831399 0.738736917369578 GO:0005080 protein kinase C binding 2/647 52/18639 0.0384615384615385 1.10801331589585 0.543207428250083 0.741206966281016 GO:0000287 magnesium ion binding 8/647 230/18639 0.0347826086956522 1.00202943350581 0.548050746026691 0.746332194444489 GO:0020037 heme binding 5/647 142/18639 0.0352112676056338 1.01437838779198 0.550528151609193 0.746332194444489 GO:0004864 protein phosphatase inhibitor activity 2/647 53/18639 0.0377358490566038 1.08710740427517 0.553561864089751 0.746332194444489 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/647 53/18639 0.0377358490566038 1.08710740427517 0.553561864089751 0.746332194444489 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0005158 insulin receptor binding 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0016493 C-C chemokine receptor activity 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0017134 fibroblast growth factor binding 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0031681 G-protein beta-subunit binding 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0043274 phospholipase binding 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0099186 structural constituent of postsynapse 1/647 23/18639 0.0434782608695652 1.25253679188227 0.556498570073591 0.746332194444489 GO:0003925 G protein activity 2/647 54/18639 0.037037037037037 1.06697578567749 0.563749177814487 0.754880314305246 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/647 24/18639 0.0416666666666667 1.20034775888717 0.571912484188459 0.758731354216122 GO:0004622 lysophospholipase activity 1/647 24/18639 0.0416666666666667 1.20034775888717 0.571912484188459 0.758731354216122 GO:0015295 solute:proton symporter activity 1/647 24/18639 0.0416666666666667 1.20034775888717 0.571912484188459 0.758731354216122 GO:0050431 transforming growth factor beta binding 1/647 24/18639 0.0416666666666667 1.20034775888717 0.571912484188459 0.758731354216122 GO:0060229 lipase activator activity 1/647 24/18639 0.0416666666666667 1.20034775888717 0.571912484188459 0.758731354216122 GO:0070300 phosphatidic acid binding 1/647 24/18639 0.0416666666666667 1.20034775888717 0.571912484188459 0.758731354216122 GO:0005516 calmodulin binding 7/647 207/18639 0.0338164251207729 0.974195282575096 0.581522376419256 0.762913419670062 GO:1990782 protein tyrosine kinase binding 4/647 117/18639 0.0341880341880342 0.984900725240756 0.582661574919836 0.762913419670062 GO:0019212 phosphatase inhibitor activity 2/647 56/18639 0.0357142857142857 1.02886950761758 0.583619141042404 0.762913419670062 GO:0001848 complement binding 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0003707 nuclear steroid receptor activity 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0005251 delayed rectifier potassium channel activity 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0015271 outward rectifier potassium channel activity 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0015662 P-type ion transporter activity 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0017056 structural constituent of nuclear pore 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0042974 nuclear retinoic acid receptor binding 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0120020 cholesterol transfer activity 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0140358 P-type transmembrane transporter activity 1/647 25/18639 0.04 1.15233384853168 0.586791486215323 0.762913419670062 GO:0019209 kinase activator activity 5/647 148/18639 0.0337837837837838 0.973254939638247 0.587469915495065 0.762913419670062 GO:0001637 G protein-coupled chemoattractant receptor activity 1/647 26/18639 0.0384615384615385 1.10801331589585 0.601154111573584 0.773682645836855 GO:0004435 phosphatidylinositol phospholipase C activity 1/647 26/18639 0.0384615384615385 1.10801331589585 0.601154111573584 0.773682645836855 GO:0004529 DNA exonuclease activity 1/647 26/18639 0.0384615384615385 1.10801331589585 0.601154111573584 0.773682645836855 GO:0004950 chemokine receptor activity 1/647 26/18639 0.0384615384615385 1.10801331589585 0.601154111573584 0.773682645836855 GO:0005160 transforming growth factor beta receptor binding 1/647 26/18639 0.0384615384615385 1.10801331589585 0.601154111573584 0.773682645836855 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/647 26/18639 0.0384615384615385 1.10801331589585 0.601154111573584 0.773682645836855 GO:0042578 phosphoric ester hydrolase activity 12/647 363/18639 0.0330578512396694 0.952342023579905 0.609825785501304 0.782520499781733 GO:0016791 phosphatase activity 9/647 273/18639 0.032967032967033 0.949725699339301 0.609838856392036 0.782520499781733 GO:0046906 tetrapyrrole binding 5/647 152/18639 0.0328947368421053 0.947642967542504 0.611154278549542 0.783041419391601 GO:0008266 poly(U) RNA binding 1/647 27/18639 0.037037037037037 1.06697578567749 0.615018254366895 0.784277370467377 GO:0008395 steroid hydroxylase activity 1/647 27/18639 0.037037037037037 1.06697578567749 0.615018254366895 0.784277370467377 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/647 27/18639 0.037037037037037 1.06697578567749 0.615018254366895 0.784277370467377 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/647 122/18639 0.0327868852459016 0.944535941419414 0.615762488311205 0.784277370467377 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/647 60/18639 0.0333333333333333 0.960278207109737 0.62133110157247 0.7890355139438 GO:0098531 ligand-modulated transcription factor activity 2/647 60/18639 0.0333333333333333 0.960278207109737 0.62133110157247 0.7890355139438 GO:0005506 iron ion binding 5/647 154/18639 0.0324675324675325 0.935335916015978 0.622696042170345 0.789604259659303 GO:0043178 alcohol binding 3/647 92/18639 0.0326086956521739 0.939402593911699 0.623765586643304 0.789797308970419 GO:0019789 SUMO transferase activity 1/647 28/18639 0.0357142857142857 1.02886950761758 0.628401189539076 0.792171924148088 GO:0051537 2 iron, 2 sulfur cluster binding 1/647 28/18639 0.0357142857142857 1.02886950761758 0.628401189539076 0.792171924148088 GO:0141052 histone H3 demethylase activity 1/647 28/18639 0.0357142857142857 1.02886950761758 0.628401189539076 0.792171924148088 GO:0016836 hydro-lyase activity 2/647 61/18639 0.0327868852459016 0.944535941419414 0.630337196640018 0.793208618632262 GO:0051213 dioxygenase activity 3/647 93/18639 0.032258064516129 0.929301490751359 0.631066090317189 0.793208618632262 GO:0031406 carboxylic acid binding 6/647 187/18639 0.0320855614973262 0.924331964062849 0.634607154777471 0.796496735077846 GO:0004181 metallocarboxypeptidase activity 1/647 29/18639 0.0344827586206897 0.993391248734211 0.641319594265754 0.80025531980118 GO:0004629 phospholipase C activity 1/647 29/18639 0.0344827586206897 0.993391248734211 0.641319594265754 0.80025531980118 GO:0035250 UDP-galactosyltransferase activity 1/647 29/18639 0.0344827586206897 0.993391248734211 0.641319594265754 0.80025531980118 GO:0099604 ligand-gated calcium channel activity 1/647 29/18639 0.0344827586206897 0.993391248734211 0.641319594265754 0.80025531980118 GO:0043177 organic acid binding 6/647 189/18639 0.0317460317460317 0.914550673437845 0.644797500101469 0.803430749041049 GO:0004519 endonuclease activity 4/647 127/18639 0.031496062992126 0.907349487032823 0.647180906735764 0.804900572052188 GO:1901682 sulfur compound transmembrane transporter activity 2/647 63/18639 0.0317460317460317 0.914550673437845 0.647846801895663 0.804900572052188 GO:0001965 G-protein alpha-subunit binding 1/647 30/18639 0.0333333333333333 0.960278207109737 0.653789568608046 0.806465356119667 GO:0001968 fibronectin binding 1/647 30/18639 0.0333333333333333 0.960278207109737 0.653789568608046 0.806465356119667 GO:0008187 poly-pyrimidine tract binding 1/647 30/18639 0.0333333333333333 0.960278207109737 0.653789568608046 0.806465356119667 GO:0031624 ubiquitin conjugating enzyme binding 1/647 30/18639 0.0333333333333333 0.960278207109737 0.653789568608046 0.806465356119667 GO:0098918 structural constituent of synapse 1/647 30/18639 0.0333333333333333 0.960278207109737 0.653789568608046 0.806465356119667 GO:0004536 DNA nuclease activity 2/647 64/18639 0.03125 0.900260819165379 0.656352016442168 0.808467934415889 GO:0047499 calcium-independent phospholipase A2 activity 1/647 31/18639 0.032258064516129 0.929301490751359 0.665826655453691 0.816633547500894 GO:0070273 phosphatidylinositol-4-phosphate binding 1/647 31/18639 0.032258064516129 0.929301490751359 0.665826655453691 0.816633547500894 GO:0072349 modified amino acid transmembrane transporter activity 1/647 31/18639 0.032258064516129 0.929301490751359 0.665826655453691 0.816633547500894 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/647 132/18639 0.0303030303030303 0.872980188281579 0.676853246178188 0.823843058279852 GO:0042910 xenobiotic transmembrane transporter activity 1/647 32/18639 0.03125 0.900260819165379 0.677445859770192 0.823843058279852 GO:0047498 calcium-dependent phospholipase A2 activity 1/647 32/18639 0.03125 0.900260819165379 0.677445859770192 0.823843058279852 GO:0071813 lipoprotein particle binding 1/647 32/18639 0.03125 0.900260819165379 0.677445859770192 0.823843058279852 GO:0071814 protein-lipid complex binding 1/647 32/18639 0.03125 0.900260819165379 0.677445859770192 0.823843058279852 GO:0120015 sterol transfer activity 1/647 32/18639 0.03125 0.900260819165379 0.677445859770192 0.823843058279852 GO:0071889 14-3-3 protein binding 1/647 33/18639 0.0303030303030303 0.872980188281579 0.688661667193672 0.835123514723593 GO:0140416 transcription regulator inhibitor activity 1/647 33/18639 0.0303030303030303 0.872980188281579 0.688661667193672 0.835123514723593 GO:0002039 p53 binding 2/647 69/18639 0.0289855072463768 0.835024527921511 0.696428256657026 0.843354049200703 GO:0008376 acetylgalactosaminyltransferase activity 1/647 34/18639 0.0294117647058824 0.847304300390945 0.699488061976306 0.843500310030251 GO:0016831 carboxy-lyase activity 1/647 34/18639 0.0294117647058824 0.847304300390945 0.699488061976306 0.843500310030251 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/647 34/18639 0.0294117647058824 0.847304300390945 0.699488061976306 0.843500310030251 GO:0004623 phospholipase A2 activity 1/647 35/18639 0.0285714285714286 0.82309560609406 0.709938544314459 0.854905016300348 GO:0030295 protein kinase activator activity 4/647 139/18639 0.0287769784172662 0.829017157217039 0.715404481850819 0.860283881108317 GO:0004190 aspartic-type endopeptidase activity 1/647 36/18639 0.0277777777777778 0.800231839258114 0.72002614707884 0.862228807558944 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/647 36/18639 0.0277777777777778 0.800231839258114 0.72002614707884 0.862228807558944 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/647 36/18639 0.0277777777777778 0.800231839258114 0.72002614707884 0.862228807558944 GO:0004521 RNA endonuclease activity 2/647 73/18639 0.0273972602739726 0.789269759268277 0.725637869183374 0.867741951898452 GO:0019213 deacetylase activity 1/647 37/18639 0.027027027027027 0.778603951710598 0.729763451967298 0.870258077761557 GO:0070001 aspartic-type peptidase activity 1/647 37/18639 0.027027027027027 0.778603951710598 0.729763451967298 0.870258077761557 GO:0003678 DNA helicase activity 2/647 74/18639 0.027027027027027 0.778603951710598 0.732558479466489 0.872382919530632 GO:0004620 phospholipase activity 3/647 109/18639 0.0275229357798165 0.792890262751159 0.734411512480852 0.873381646748637 GO:0046982 protein heterodimerization activity 11/647 369/18639 0.029810298102981 0.858785388472123 0.738503968433768 0.875238689183198 GO:0000146 microfilament motor activity 1/647 38/18639 0.0263157894736842 0.758114374034003 0.739162605100142 0.875238689183198 GO:0005109 frizzled binding 1/647 38/18639 0.0263157894736842 0.758114374034003 0.739162605100142 0.875238689183198 GO:0004222 metalloendopeptidase activity 3/647 110/18639 0.0272727272727273 0.785682169453421 0.740039216870346 0.875238689183198 GO:0051536 iron-sulfur cluster binding 2/647 76/18639 0.0263157894736842 0.758114374034003 0.745954885669796 0.881024906120294 GO:0000217 DNA secondary structure binding 1/647 39/18639 0.0256410256410256 0.738675543930567 0.748235332077198 0.881300439012951 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/647 39/18639 0.0256410256410256 0.738675543930567 0.748235332077198 0.881300439012951 GO:0004175 endopeptidase activity 12/647 405/18639 0.0296296296296296 0.853580628541989 0.752156530126078 0.883828467029698 GO:0051540 metal cluster binding 2/647 77/18639 0.025974025974026 0.748268732812782 0.752434687959081 0.883828467029698 GO:0015144 carbohydrate transmembrane transporter activity 1/647 40/18639 0.025 0.720208655332303 0.756992952515157 0.885558331678737 GO:0061791 GTPase motor activity 1/647 40/18639 0.025 0.720208655332303 0.756992952515157 0.885558331678737 GO:1990606 membrane scission GTPase motor activity 1/647 40/18639 0.025 0.720208655332303 0.756992952515157 0.885558331678737 GO:0033293 monocarboxylic acid binding 2/647 79/18639 0.0253164556962025 0.729325220589674 0.764967790297607 0.8921436804137 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/647 41/18639 0.024390243902439 0.7026425905681 0.765446394083128 0.8921436804137 GO:0035401 histone H3Y41 kinase activity 3/647 115/18639 0.0260869565217391 0.75152207512936 0.766766926255677 0.8921436804137 GO:0140801 histone H2AXY142 kinase activity 3/647 115/18639 0.0260869565217391 0.75152207512936 0.766766926255677 0.8921436804137 GO:0000049 tRNA binding 2/647 80/18639 0.025 0.720208655332303 0.771025302573928 0.892861854439964 GO:0048306 calcium-dependent protein binding 2/647 80/18639 0.025 0.720208655332303 0.771025302573928 0.892861854439964 GO:0008307 structural constituent of muscle 1/647 42/18639 0.0238095238095238 0.685913005078384 0.773606206053674 0.892861854439964 GO:0031492 nucleosomal DNA binding 1/647 42/18639 0.0238095238095238 0.685913005078384 0.773606206053674 0.892861854439964 GO:0042056 chemoattractant activity 1/647 42/18639 0.0238095238095238 0.685913005078384 0.773606206053674 0.892861854439964 GO:0043175 RNA polymerase core enzyme binding 1/647 42/18639 0.0238095238095238 0.685913005078384 0.773606206053674 0.892861854439964 GO:0030971 receptor tyrosine kinase binding 2/647 81/18639 0.0246913580246914 0.711317190451657 0.776946304423957 0.895516423171388 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/647 43/18639 0.0232558139534884 0.669961539844003 0.781482572386054 0.89833977947182 GO:0008375 acetylglucosaminyltransferase activity 1/647 43/18639 0.0232558139534884 0.669961539844003 0.781482572386054 0.89833977947182 GO:0030165 PDZ domain binding 2/647 83/18639 0.0240963855421687 0.694177017187762 0.788387434828415 0.901064276222877 GO:0003954 NADH dehydrogenase activity 1/647 44/18639 0.0227272727272727 0.654735141211184 0.789085324357781 0.901064276222877 GO:0016790 thiolester hydrolase activity 1/647 44/18639 0.0227272727272727 0.654735141211184 0.789085324357781 0.901064276222877 GO:0019205 nucleobase-containing compound kinase activity 1/647 44/18639 0.0227272727272727 0.654735141211184 0.789085324357781 0.901064276222877 GO:0043014 alpha-tubulin binding 1/647 44/18639 0.0227272727272727 0.654735141211184 0.789085324357781 0.901064276222877 GO:0051539 4 iron, 4 sulfur cluster binding 1/647 45/18639 0.0222222222222222 0.640185471406492 0.796423952760067 0.90703839064341 GO:0140303 intramembrane lipid transporter activity 1/647 45/18639 0.0222222222222222 0.640185471406492 0.796423952760067 0.90703839064341 GO:0008236 serine-type peptidase activity 5/647 194/18639 0.0257731958762887 0.742483149827116 0.807698205010177 0.915626235200894 GO:0008081 phosphoric diester hydrolase activity 2/647 87/18639 0.0229885057471264 0.662260832489474 0.809727434133448 0.915626235200894 GO:0005504 fatty acid binding 1/647 47/18639 0.0212765957446809 0.612943536453024 0.810345169829363 0.915626235200894 GO:0061749 forked DNA-dependent helicase activity 1/647 47/18639 0.0212765957446809 0.612943536453024 0.810345169829363 0.915626235200894 GO:0140938 histone H3 methyltransferase activity 1/647 47/18639 0.0212765957446809 0.612943536453024 0.810345169829363 0.915626235200894 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/647 47/18639 0.0212765957446809 0.612943536453024 0.810345169829363 0.915626235200894 GO:0009378 four-way junction helicase activity 1/647 48/18639 0.0208333333333333 0.600173879443586 0.816945141597887 0.918263403284309 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/647 48/18639 0.0208333333333333 0.600173879443586 0.816945141597887 0.918263403284309 GO:0036121 double-stranded DNA helicase activity 1/647 48/18639 0.0208333333333333 0.600173879443586 0.816945141597887 0.918263403284309 GO:0043138 3'-5' DNA helicase activity 1/647 48/18639 0.0208333333333333 0.600173879443586 0.816945141597887 0.918263403284309 GO:0017171 serine hydrolase activity 5/647 198/18639 0.0252525252525253 0.727483490234649 0.821432025479971 0.922102964717412 GO:0048020 CCR chemokine receptor binding 1/647 50/18639 0.02 0.576166924265842 0.829465034801836 0.92990806635987 GO:0016298 lipase activity 3/647 130/18639 0.0230769230769231 0.66480798953751 0.833728260091004 0.931709730589662 GO:0016597 amino acid binding 1/647 51/18639 0.0196078431372549 0.564869533593963 0.835400594675052 0.931709730589662 GO:0016830 carbon-carbon lyase activity 1/647 51/18639 0.0196078431372549 0.564869533593963 0.835400594675052 0.931709730589662 GO:0030544 Hsp70 protein binding 1/647 51/18639 0.0196078431372549 0.564869533593963 0.835400594675052 0.931709730589662 GO:0030159 signaling receptor complex adaptor activity 1/647 52/18639 0.0192307692307692 0.554006657947925 0.84112987244809 0.935979571431358 GO:0016410 N-acyltransferase activity 2/647 94/18639 0.0212765957446809 0.612943536453024 0.84249032271696 0.935979571431358 GO:0042562 hormone binding 2/647 94/18639 0.0212765957446809 0.612943536453024 0.84249032271696 0.935979571431358 GO:0005246 calcium channel regulator activity 1/647 53/18639 0.0188679245283019 0.543553702137587 0.846660026454981 0.93819084012579 GO:0005544 calcium-dependent phospholipid binding 1/647 53/18639 0.0188679245283019 0.543553702137587 0.846660026454981 0.93819084012579 GO:0050661 NADP binding 1/647 54/18639 0.0185185185185185 0.533487892838743 0.851997966995368 0.942892351649115 GO:0019838 growth factor binding 3/647 136/18639 0.0220588235294118 0.635478225293209 0.855490587894235 0.945542228725207 GO:0098632 cell-cell adhesion mediator activity 1/647 55/18639 0.0181818181818182 0.523788112968948 0.857150364915949 0.946162133580297 GO:0030170 pyridoxal phosphate binding 1/647 56/18639 0.0178571428571429 0.514434753808788 0.862123659895468 0.950433381779767 GO:0004252 serine-type endopeptidase activity 4/647 176/18639 0.0227272727272727 0.654735141211184 0.864119612644795 0.951415583743182 GO:0070279 vitamin B6 binding 1/647 57/18639 0.0175438596491228 0.505409582689335 0.866924068443476 0.952350819920021 GO:0004713 protein tyrosine kinase activity 3/647 140/18639 0.0214285714285714 0.617321704570545 0.868579002590258 0.952350819920021 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/647 58/18639 0.0172413793103448 0.496695624367105 0.871557591622739 0.952350819920021 GO:0017116 single-stranded DNA helicase activity 1/647 58/18639 0.0172413793103448 0.496695624367105 0.871557591622739 0.952350819920021 GO:0022804 active transmembrane transporter activity 12/647 457/18639 0.0262582056892779 0.756455480436554 0.873583093845486 0.952350819920021 GO:0015171 amino acid transmembrane transporter activity 2/647 102/18639 0.0196078431372549 0.564869533593963 0.873609396626347 0.952350819920021 GO:0004879 nuclear receptor activity 1/647 59/18639 0.0169491525423729 0.488277054462578 0.876030022504828 0.952350819920021 GO:0015459 potassium channel regulator activity 1/647 59/18639 0.0169491525423729 0.488277054462578 0.876030022504828 0.952350819920021 GO:0036002 pre-mRNA binding 1/647 59/18639 0.0169491525423729 0.488277054462578 0.876030022504828 0.952350819920021 GO:0070888 E-box binding 1/647 59/18639 0.0169491525423729 0.488277054462578 0.876030022504828 0.952350819920021 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/647 181/18639 0.0220994475138122 0.636648535100378 0.877966709173868 0.953252631272005 GO:0001098 basal transcription machinery binding 1/647 60/18639 0.0166666666666667 0.480139103554869 0.880346953368088 0.953432360817514 GO:0001099 basal RNA polymerase II transcription machinery binding 1/647 60/18639 0.0166666666666667 0.480139103554869 0.880346953368088 0.953432360817514 GO:0008194 UDP-glycosyltransferase activity 3/647 145/18639 0.0206896551724138 0.596034749240527 0.883461812671601 0.955541238217028 GO:0015026 coreceptor activity 1/647 61/18639 0.0163934426229508 0.472267970709707 0.884513782646889 0.955541238217028 GO:0004497 monooxygenase activity 2/647 106/18639 0.0188679245283019 0.543553702137587 0.886951058191487 0.956973510153973 GO:0015179 L-amino acid transmembrane transporter activity 1/647 62/18639 0.0161290322580645 0.464650745375679 0.888535721640724 0.9574834246967 GO:0120013 lipid transfer activity 1/647 65/18639 0.0153846153846154 0.44320532635834 0.899781637347012 0.967181010931058 GO:0160215 deacylase activity 1/647 65/18639 0.0153846153846154 0.44320532635834 0.899781637347012 0.967181010931058 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/647 67/18639 0.0149253731343284 0.4299753166163 0.906642155980428 0.9721281398495 GO:0042054 histone methyltransferase activity 1/647 67/18639 0.0149253731343284 0.4299753166163 0.906642155980428 0.9721281398495 GO:0005261 monoatomic cation channel activity 8/647 341/18639 0.0234604105571848 0.675855629637352 0.909110555729911 0.973191508232003 GO:0005548 phospholipid transporter activity 1/647 68/18639 0.0147058823529412 0.423652150195472 0.909894499566507 0.973191508232003 GO:0008080 N-acetyltransferase activity 1/647 69/18639 0.0144927536231884 0.417512263960755 0.913033709021058 0.974128901446259 GO:0016279 protein-lysine N-methyltransferase activity 1/647 69/18639 0.0144927536231884 0.417512263960755 0.913033709021058 0.974128901446259 GO:0016278 lysine N-methyltransferase activity 1/647 70/18639 0.0142857142857143 0.41154780304703 0.916063713881768 0.976152051549755 GO:0099106 ion channel regulator activity 3/647 160/18639 0.01875 0.540156491499227 0.919491551148253 0.978593603879661 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/647 73/18639 0.0136986301369863 0.394634879634139 0.924535780199323 0.982747292285946 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/647 122/18639 0.0163934426229508 0.472267970709707 0.928274970014328 0.98550523943568 GO:0098631 cell adhesion mediator activity 1/647 76/18639 0.0131578947368421 0.379057187017002 0.932153910276584 0.988404577276033 GO:0016247 channel regulator activity 3/647 168/18639 0.0178571428571429 0.514434753808788 0.934246900706498 0.989405389309096 GO:0019199 transmembrane receptor protein kinase activity 1/647 78/18639 0.0128205128205128 0.369337771965284 0.936801065607862 0.99044017995029 GO:0141108 transporter regulator activity 3/647 170/18639 0.0176470588235294 0.508382580234567 0.937524676724142 0.99044017995029 GO:0008201 heparin binding 3/647 172/18639 0.0174418604651163 0.502471154883002 0.940650982239497 0.99252511728947 GO:0022832 voltage-gated channel activity 3/647 175/18639 0.0171428571428571 0.493857363656436 0.945069837250318 0.99596711122708 GO:0005254 chloride channel activity 1/647 83/18639 0.0120481927710843 0.347088508593881 0.947075434748529 0.996860573738977 GO:0140767 enzyme-substrate adaptor activity 2/647 139/18639 0.0143884892086331 0.41450857860852 0.956343004669577 0.999991939886608 GO:1901681 sulfur compound binding 5/647 275/18639 0.0181818181818182 0.523788112968948 0.964231792255649 0.999991939886608 GO:0015293 symporter activity 2/647 146/18639 0.0136986301369863 0.394634879634139 0.964532482573058 0.999991939886608 GO:0004867 serine-type endopeptidase inhibitor activity 1/647 95/18639 0.0105263157894737 0.303245749613601 0.9654343170936 0.999991939886608 GO:0008276 protein methyltransferase activity 1/647 95/18639 0.0105263157894737 0.303245749613601 0.9654343170936 0.999991939886608 GO:0015085 calcium ion transmembrane transporter activity 2/647 147/18639 0.0136054421768707 0.391950288616219 0.965574556465084 0.999991939886608 GO:0016407 acetyltransferase activity 1/647 96/18639 0.0104166666666667 0.300086939721793 0.966640313471967 0.999991939886608 GO:0030594 neurotransmitter receptor activity 1/647 97/18639 0.0103092783505155 0.296993259930847 0.967804295415754 0.999991939886608 GO:0005249 voltage-gated potassium channel activity 1/647 98/18639 0.0102040816326531 0.293962716462164 0.968927724434522 0.999991939886608 GO:0008170 N-methyltransferase activity 1/647 98/18639 0.0102040816326531 0.293962716462164 0.968927724434522 0.999991939886608 GO:0005539 glycosaminoglycan binding 4/647 242/18639 0.0165289256198347 0.476171011789952 0.970561682219719 0.999991939886608 GO:0005253 monoatomic anion channel activity 1/647 103/18639 0.00970873786407767 0.279692681682448 0.973984271921852 0.999991939886608 GO:0005216 monoatomic ion channel activity 9/647 448/18639 0.0200892857142857 0.578739098034886 0.975221781482297 0.999991939886608 GO:0015294 solute:monoatomic cation symporter activity 1/647 116/18639 0.00862068965517241 0.248347812183553 0.983609944653459 0.999991939886608 GO:0005244 voltage-gated monoatomic ion channel activity 2/647 173/18639 0.0115606936416185 0.33304446489355 0.984322011421161 0.999991939886608 GO:0015108 chloride transmembrane transporter activity 1/647 121/18639 0.00826446280991736 0.238085505894976 0.986279591908737 0.999991939886608 GO:0005319 lipid transporter activity 2/647 178/18639 0.0112359550561798 0.323689283295417 0.986552701675658 0.999991939886608 GO:0008528 G protein-coupled peptide receptor activity 1/647 122/18639 0.00819672131147541 0.236133985354853 0.986758968949187 0.999991939886608 GO:0005267 potassium channel activity 1/647 124/18639 0.00806451612903226 0.23232537268784 0.987668133724714 0.999991939886608 GO:0001653 peptide receptor activity 1/647 128/18639 0.0078125 0.225065204791345 0.989303723535035 0.999991939886608 GO:0046943 carboxylic acid transmembrane transporter activity 2/647 188/18639 0.0106382978723404 0.306471768226512 0.990125762315674 0.999991939886608 GO:0005262 calcium channel activity 1/647 131/18639 0.00763358778625954 0.219911039796123 0.990386610076118 0.999991939886608 GO:0005342 organic acid transmembrane transporter activity 2/647 189/18639 0.0105820105820106 0.304850224479282 0.990427332101389 0.999991939886608 GO:0015297 antiporter activity 1/647 135/18639 0.00740740740740741 0.213395157135497 0.991662102042776 0.999991939886608 GO:0099094 ligand-gated monoatomic cation channel activity 1/647 136/18639 0.00735294117647059 0.211826075097736 0.991953640087433 0.999991939886608 GO:0022843 voltage-gated monoatomic cation channel activity 1/647 143/18639 0.00699300699300699 0.201456966526518 0.993728436998613 0.999991939886608 GO:0008509 monoatomic anion transmembrane transporter activity 1/647 149/18639 0.00671140939597315 0.193344605458336 0.99493499991921 0.999991939886608 GO:0019842 vitamin binding 1/647 150/18639 0.00666666666666667 0.192055641421947 0.995112233832259 0.999991939886608 GO:0016741 transferase activity, transferring one-carbon groups 2/647 215/18639 0.00930232558139535 0.267984615937601 0.995758838634416 0.999991939886608 GO:0022836 gated channel activity 4/647 318/18639 0.0125786163522013 0.362369134758391 0.995938936689986 0.999991939886608 GO:0015079 potassium ion transmembrane transporter activity 1/647 160/18639 0.00625 0.180052163833076 0.996577265574706 0.999991939886608 GO:0015103 inorganic anion transmembrane transporter activity 1/647 165/18639 0.00606060606060606 0.174596037656316 0.997136002567569 0.999991939886608 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/647 229/18639 0.00873362445414847 0.251601276971984 0.9972789679042 0.999991939886608 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/647 167/18639 0.00598802395209581 0.172505067145462 0.997333101903238 0.999991939886608 GO:0005201 extracellular matrix structural constituent 1/647 168/18639 0.00595238095238095 0.171478251269596 0.997426512636705 0.999991939886608 GO:0015291 secondary active transmembrane transporter activity 3/647 287/18639 0.0104529616724739 0.3011325388149 0.99758665257581 0.999991939886608 GO:0015276 ligand-gated monoatomic ion channel activity 1/647 186/18639 0.00537634408602151 0.154883581791893 0.998645880017418 0.999991939886608 GO:0022834 ligand-gated channel activity 1/647 188/18639 0.00531914893617021 0.153235884113256 0.998739174260301 0.999991939886608 GO:0008514 organic anion transmembrane transporter activity 2/647 269/18639 0.00743494423791822 0.214188447682469 0.999247685553481 0.999991939886608 GO:0008168 methyltransferase activity 1/647 204/18639 0.00490196078431373 0.141217383398491 0.999287942291754 0.999991939886608 GO:0045182 translation regulator activity 3/647 356/18639 0.00842696629213483 0.242766962471563 0.999698246668994 0.999991939886608 GO:0046873 metal ion transmembrane transporter activity 3/647 450/18639 0.00666666666666667 0.192055641421947 0.999984178109079 0.999991939886608 GO:0030371 translation repressor activity 1/647 329/18639 0.00303951367781155 0.087563362350432 0.999991939886608 0.999991939886608