category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	83/2390	157/9376	2.0739493110892	IGFBP3/SERPINE1/MYC/SIRT1/ZFP36L2/PPP1CB/RHEB/ZFP36L1/AKT1/GADD45A/GADD45B/PPP3CC/CDKN1A/TGFB2/RAF1/HIPK3/HIPK1/TGFBR1/TSC2/TGFB3/TRPM7/GATA4/TSC1/MAPK14/SMAD3/SMAD2/RB1/MAP2K1/MDM2/TRAF3IP2/ATM/PIK3CA/RELA/PPP3R1/CCND3/BTRC/PPP3CB/HLA-F/RRAS2/PPP3CA/MAPK1/CAPN2/CDK2/PPID/GADD45G/VDAC1/RBL2/PTEN/VDAC2/TGFBR2/RAD50/MCU/CDKN2B/AKT2/RBL1/IL6/FOXO1/NFKB1/NFATC3/SQSTM1/HUS1/RAD9A/RRAS/ATR/CDKN2A/LIN37/HIPK2/FOXO3/ITPR3/E2F5/AKT3/CALM2/MRE11/CCNA2/PIK3R2/MAPK13/PIK3CB/CHEK2/MAPK12/PIK3R3/E2F1/LIN9/CDK1	7.93710271305563
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	53/2390	83/9376	2.50505620809598	PHF1/OGT/AEBP2/PHC3/BMI1/PHC2/FOXK1/ASXL1/KDM2A/FBRS/CBX4/PCGF3/MBD5/SKP1/CBX8/SCML1/UBE2D1/PCGF5/SCMH1/UBE2D3/FOXK2/RYBP/PHC1/FBRSL1/MAX/PHF19/WDR5/RNF2/CSNK2B/LCOR/CBX7/CREBBP/MGA/YY1/EED/JARID2/PCGF6/AUTS2/PCGF2/BCOR/SUZ12/L3MBTL3/RING1/PCGF1/TFDP1/SFMBT2/TEX10/KDM2B/YY2/E2F6/L3MBTL2/L3MBTL4/USP45	8.05534406672444
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	68/2390	119/9376	2.24172145845786	SOCS3/JUNB/CEBPB/JUN/FOS/NFKBIA/FAS/MAP3K8/IRF1/AKT1/IL18R1/ITCH/MAPK8/RHBDF1/ATF2/CASP10/MAPK14/MAP2K1/BIRC2/MMP14/CASP3/CASP7/PIK3CA/RELA/CSF1/CREB3L2/MAP3K7/DNM1L/TAB3/MAPK1/BAG4/TNFRSF1A/ATF4/TAB2/XIAP/ADAM17/LIF/MAPK9/IL15/AKT2/IL6/MAP2K4/RIPK1/CYLD/NFKB1/TRAF5/CREB5/MAP3K5/JAG1/DAB2IP/CASP8/AKT3/CHUK/VEGFC/CXCL10/PIK3R2/MAPK13/PIK3CB/MAPK12/TRAF3/PTGS2/TAB1/PIK3R3/PGAM5/CREB3L4/MAPK10/TNFAIP3/CXCL1	7.97320321448607
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	77/2390	142/9376	2.12726736990984	SOCS1/SOCS3/HERC4/UBE2B/UBE2S/RCHY1/SYVN1/UBE2A/ITCH/SMURF2/PML/UBE2N/UBE2W/SIAH1/FBXW7/UBE2L6/SKP1/UBE3C/CBLB/UBE2Z/MDM2/CDC34/UBE2D1/UBR5/NEDD4/HERC2/UBE2D3/UBE2Q2/BIRC2/ELOC/CUL4A/PIAS2/CDC16/BIRC6/HERC3/UBA3/TRAF6/UBE2Q1/CUL3/BTRC/UBE2J2/UBA6/UBE2E1/UBE2M/UBE2I/ANAPC10/UBE3A/UBA2/CUL5/UBE2H/ANAPC1/ANAPC16/CDC26/CUL1/MGRN1/XIAP/UBE2F/SMURF1/UBE2G1/COP1/UBE2J1/UBE3B/VHL/MID1/ANAPC4/DDB2/KLHL9/PPIL2/MAP3K1/CDC23/CUL4B/SKP2/CUL7/ANAPC7/FANCL/TRIM37/DET1	7.91674162166768
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	72/2390	133/9376	2.12373611853903	IRS2/KLF2/SIRT1/BCL6/CSNK1E/SMAD4/BNIP3/GABARAPL1/AKT1/GADD45A/GADD45B/CDKN1A/SOS2/IGF1R/TGFB2/RAF1/INSR/IRS1/BRAF/FBXO32/ATG12/MAPK8/TGFBR1/STAT3/TGFB3/MAPK14/SMAD3/MAP2K1/MDM2/SOS1/ATM/PLK2/CDKN2D/PIK3CA/STK11/PRKAG2/PRKAA1/PLK3/SOD2/MAPK1/CDK2/CCNG2/GADD45G/ARAF/RBL2/PTEN/CREBBP/MAPK9/TGFBR2/PDPK1/BCL2L11/CDKN2B/AKT2/GABARAPL2/IL6/SETD7/FOXO1/DEPP1/PRKAB1/FOXO3/SKP2/AKT3/CHUK/HOMER1/PIK3R2/MAPK13/PIK3CB/PRKAB2/MAPK12/PIK3R3/MAPK10/NLK	7.63403210317338
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	81/2390	157/9376	2.02397462889428	SERPINE1/ID1/SMAD7/MYC/LATS2/PPP1CB/CSNK1E/SMAD4/CTNNB1/TEAD1/LLGL2/SAV1/TGFB2/PPP2CB/LLGL1/BBC3/PPP2R2D/TGFBR1/STK3/TGFB3/YAP1/BMP2/GDF5/DVL1/SMAD3/SMAD2/WTIP/PPP2R2A/AXIN2/BIRC2/ID2/FZD2/BMPR1A/GDF6/DLG4/AXIN1/CCND3/BTRC/FZD7/AJUBA/PPP2R1B/DVL2/TEAD3/PARD3/FRMD6/YWHAG/GLI2/LATS1/MOB1A/DLG5/BMP6/PATJ/PPP2CA/TCF7L2/TGFBR2/WNT2B/YWHAQ/DLG1/CTNNA1/WNT6/WWTR1/PRKCI/FZD1/AMH/WNT9A/FZD6/WNT10A/NKD1/BMP7/WNT11/FZD5/PARD6G/LEF1/SMAD1/NKD2/NF2/ACTB/YWHAZ/MOB1B/WNT7B/BMP4	7.56776108627894
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	83/2390	163/9376	1.99760761865647	IRF7/STAT1/JUN/FOS/NFKBIA/STAT2/IFIH1/MYC/FAS/STAT5B/SMAD4/CYCS/AKT1/TBK1/DDX3X/CDKN1A/SOS2/TGFB2/RAF1/BRAF/MAPK8/ATF2/TGFBR1/STAT3/TGFB3/CASP10/MAPK14/SMAD3/RB1/MAP2K1/SOS1/CASP3/PIK3CA/RELA/PRKCA/TRAF6/CREB3L2/MAP3K7/APAF1/STAT6/MAPK1/JAK2/IRAK4/CDK2/ARAF/ATF4/TAB2/HSPG2/CREBBP/STAT5A/MAPK9/TGFBR2/YWHAQ/MYD88/AKT2/JAK3/IL6/MAP2K4/NFKB1/NFATC3/DDB2/BCL2/CREB5/TICAM1/MAP3K1/IFNAR1/CASP9/CASP8/AKT3/CHUK/CCNA2/PIK3R2/MAPK13/PIK3CB/YWHAZ/MAPK12/TRAF3/TAB1/PIK3R3/E2F1/CREB3L4/MAPK10/ELK1	7.51490200640989
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	130/2390	300/9376	1.69997210599721	DUSP1/JUN/FOS/VEGFA/DUSP8/JUND/HSPA1B/PLA2G4A/PDGFA/MKNK2/MYC/NR4A1/FAS/MAP3K8/MAP4K3/DUSP7/AKT1/GADD45A/GADD45B/PPP3CC/SOS2/IGF1R/TGFB2/RAF1/INSR/BRAF/IL1RAP/DUSP5/MAPK8/ATF2/TGFBR1/STK3/TGFB3/MAPK14/MAP2K1/SOS1/RASA2/NFKB2/FGF2/LAMTOR3/CASP3/GDNF/PPM1B/RELA/PDGFRB/MAP3K2/PRKCA/CSF1/MAP3K12/PPP3R1/GNA12/TRAF6/CACNA2D1/RAP1A/ELK4/PPP3CB/MAPK7/NF1/MAPK8IP3/GNG12/RRAS2/MAX/MAP3K7/PPM1A/PPP3CA/MAPKAPK5/DUSP9/FGFR2/HSPA1A/MAPK1/TNFRSF1A/DDIT3/IRAK4/GADD45G/ARAF/ATF4/HSPA8/TAB2/CRKL/RAPGEF2/IL1R1/VEGFB/MAPK9/FGFR3/TGFBR2/MAP3K4/DUSP16/PDGFRA/FGF10/RAP1B/MYD88/AKT2/FLT3LG/MAP2K4/CACNB2/FGFR4/FGFR1/NFKB1/NFATC3/CACNA1A/RRAS/PDGFC/KITLG/MAPK8IP1/MAP3K1/EPHA2/RPS6KA3/MAPT/MAP3K5/RET/EFNA5/FGF22/TAOK2/RELB/AKT3/NTF3/CDC42/CHUK/MAP3K10/VEGFC/MAPK13/MAPK12/CACNA2D2/TAB1/MAPK10/NLK/DUSP10/NGF/ELK1/CACNB4	7.20716417968314
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	60/2390	108/9376	2.17945141794514	EIF4A3/DDX39B/NUP160/NXT1/NUP58/NXF1/NUP98/THOC3/NUP153/KPNA4/RNPS1/XPO4/THOC1/SUMO1/XPO1/KPNA5/XPOT/NUP155/NUP54/UBE2I/ACIN1/NMD3/THOC7/MAGOH/RANBP17/POM121C/CSE1L/UPF1/TNPO3/SUMO4/ALYREF/MAGOHB/DDX19A/THOC6/SEC13/TNPO2/NUP93/SEH1L/IPO7/NUP85/RANBP2/NUP188/NUP50/AHCTF1/SENP2/NUP107/KPNA2/XPO7/KPNA1/NUP205/SUMO2/XPO5/TNPO1/NUP88/NCBP2/NUP35/NUP43/IPO11/NXT2/NDC1	7.2105637360272
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	83/2390	169/9376	1.92668663811245	IRS2/DDIT4/RHEB/BNIP3/GABARAPL1/AKT1/WDFY3/TBK1/TANK/IGF1R/RAF1/IRS1/SUPT20H/RAB33B/PPP2CB/EIF2AK3/ATG12/MAPK8/MTMR3/EIF2S1/TSC2/ULK1/DAPK1/TSC1/RPS6KB1/MAP2K1/ERN1/STX7/PIK3CA/STK11/EPG5/BIRC6/MAP1LC3C/CALCOCO2/RAB8A/RAB1A/PRKCD/TRAF6/PRKAA1/RRAS2/MAP3K7/MAPK1/DAPK3/MAP1LC3B/ATG5/GORASP1/PTEN/RRAGB/MAPK9/PPP2CA/DEPTOR/PDPK1/AKT2/GABARAPL2/MTMR4/ATG16L1/ATG101/SQSTM1/GORASP2/ATG13/ATG2B/RRAS/PLEKHM1/RB1CC1/VMP1/BCL2/ULK2/WIPI1/C9orf72/ZFYVE1/RUBCN/HIF1A/AMBRA1/AKT3/PIK3R4/PIK3R2/PIK3CB/WDR41/VPS33A/RPTOR/PIK3R3/MAPK10/TP53INP2	7.11029270995952
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	50/2390	87/9376	2.25460491511566	JUN/FOS/MYC/SMAD4/CTNNB1/CYCS/AKT1/GADD45A/GADD45B/POLK/CDKN1A/SOS2/TGFB2/RAF1/BRAF/BBC3/MAPK8/TGFBR1/TGFB3/RPS6KB1/SMAD3/SMAD2/MAP2K1/SOS1/AXIN2/CASP3/PIK3CA/AXIN1/MLH1/MAPK1/GADD45G/ARAF/MSH6/MAPK9/TCF7L2/TGFBR2/BCL2L11/RALA/AKT2/DDB2/BCL2/LEF1/CASP9/AKT3/PIK3R2/PIK3CB/MSH3/MSH2/PIK3R3/MAPK10	6.87626218454023
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	82/2390	174/9376	1.84877603039484	PPP1R15A/XBP1/SEC23A/HSPA1B/SEC24D/SYVN1/SEC24A/ERO1A/SEC61G/HSPH1/UBQLN1/EIF2AK3/SAR1B/MAPK8/RNF5/EIF2S1/DNAJA1/ERO1B/AMFR/SKP1/PDIA4/OSTC/UBE2D1/HERPUD1/ERN1/UBE2D3/DNAJB2/MOGS/DERL2/KRTCAP2/SAR1A/UBXN2A/CRYAB/NGLY1/BCAP29/UBE2J2/DAD1/DNAJB11/SEC24C/BAG2/HSPA4L/HSPA1A/CAPN2/SEC24B/MBTPS1/RAD23B/DDIT3/SSR3/DERL1/ATXN3/RAD23A/CUL1/ATF4/TRAM1/TXNDC5/HSPA8/MAN1A1/HYOU1/RPN1/UBE2G1/MAPK9/STT3B/EDEM3/UBE2J1/SEC13/FBXO6/DNAJB1/PDIA6/UGGT2/ERLEC1/MBTPS2/BCL2/SEC61B/CALR/MAP3K5/SEC23B/EDEM1/TMEM258/SEC31A/HSPA5/MAPK10/EDEM2	6.60993082076754
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	62/2390	122/9376	1.99366211674326	IRS2/SIRT1/RHEB/AKT1/PFKP/IGF1R/INSR/IRS1/PPP2CB/ADIPOR1/PPP2R2D/CRTC2/TSC2/ULK1/TSC1/RPS6KB1/PPP2R2A/EEF2K/PIK3CA/STK11/PRKAG2/RAB8A/PPP2R3C/PRKAA1/ELAVL1/CREB3L2/CAB39/MAP3K7/PPP2R1B/LEPR/PPP2CA/PDPK1/AKT2/STRADB/FOXO1/RAB14/ADIPOR2/PPP2R5A/CAB39L/CREB5/PPP2R5E/PRKAB1/PPP2R3A/CPT1B/FOXO3/ACACA/SREBF1/HMGCR/STRADA/ACACB/PFKFB3/AKT3/PPP2R3B/CCNA2/PIK3R2/PIK3CB/PRKAB2/RPTOR/PIK3R3/CREB3L4/GYS1/PPP2R5B	6.46136386372124
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	98/2390	224/9376	1.7163179916318	ZFP36/EGR1/JUN/FOS/NFKBIA/MSX1/MYC/STAT5B/SMAD4/ETS2/ADCY9/CRTC3/AKT1/IL15RA/PPP3CC/CDKN1A/TGFB2/MAPK8/ATF2/TGFBR1/CRTC2/TGFB3/SMAD3/SMAD2/RB1/MAP2K1/TBPL1/NFKB2/ATM/XPO1/NFYB/PIK3CA/CDC16/RELA/PPP3R1/BUB3/TRRAP/CCND3/CREB3L2/ELK4/PPP3CB/HLA-F/PPP3CA/ANAPC10/ANAPC1/ANAPC16/MAPK1/CDC26/TNFRSF1A/CDK2/ATF4/VDAC1/XIAP/PTEN/CREBBP/IL1R1/KAT2B/STAT5A/MAPK9/VDAC2/TGFBR2/IL15/DLG1/CDKN2B/AKT2/JAK3/IL6/KAT2A/MAP2K4/ADCY3/RANBP1/NFKB1/NFATC3/ANAPC4/ATR/CREB5/MAP3K1/CDKN2A/CALR/GPS2/TCF3/CDC23/ADCY6/RELB/AKT3/CHUK/CCNA2/ANAPC7/MSX2/PIK3R2/PIK3CB/CHEK2/PIK3R3/E2F1/CREB3L4/MAPK10/ELK1/B2M	6.34661510273193
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	70/2390	144/9376	1.907019990702	ID4/KLF4/ID1/MEIS1/ID3/MYC/SKIL/SMAD4/CTNNB1/BMI1/AKT1/IGF1R/RAF1/PCGF3/STAT3/ACVR1B/MAPK14/DVL1/SMAD3/SMAD2/MAP2K1/PCGF5/AXIN2/FGF2/PIK3CA/ID2/FZD2/BMPR1A/AXIN1/FZD7/DVL2/DUSP9/FGFR2/MAPK1/JAK2/KAT6A/LIF/FGFR3/WNT2B/AKT2/JAK3/ACVR2B/TBX3/WNT6/JARID2/FGFR4/SMARCAD1/FGFR1/FZD1/RIF1/PCGF6/ACVR1/PCGF2/WNT9A/FZD6/WNT10A/PCGF1/WNT11/FZD5/TCF3/SMAD1/AKT3/INHBB/PIK3R2/MAPK13/PIK3CB/MAPK12/WNT7B/PIK3R3/BMP4	6.41535221819093
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	44/2390	77/9376	2.24172145845786	NFKBIA/MYC/STAT5B/SMAD4/CTBP2/AKT1/GADD45A/ABL1/GADD45B/POLK/CDKN1A/SOS2/TGFB2/RAF1/BRAF/TGFBR1/SHC2/CTBP1/TGFB3/SMAD3/RB1/MAP2K1/MDM2/SOS1/PIK3CA/RELA/MAPK1/GADD45G/ARAF/CRKL/STAT5A/TGFBR2/AKT2/GAB2/NFKB1/BCR/DDB2/CDKN2A/AKT3/CHUK/PIK3R2/PIK3CB/PIK3R3/E2F1	6.39914164046345
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	74/2390	158/9376	1.83736030930565	DDIT4/GRB10/FLCN/RICTOR/RHEB/LPIN1/AKT1/FNIP1/SOS2/IGF1R/RAF1/INSR/IRS1/BRAF/TSC2/ULK1/EIF4E/TSC1/RPS6KB1/DVL1/MAP2K1/SOS1/LAMTOR3/PIK3CA/STK11/FZD2/PRKCA/CASTOR1/PRKAA1/FZD7/CAB39/LPIN3/DVL2/WDR59/TBC1D7/MAPK1/TNFRSF1A/PTEN/SLC38A9/ATP6V1E2/RRAGB/DEPTOR/PDPK1/WNT2B/SLC3A2/AKT2/SEC13/WNT6/SEH1L/STRADB/FZD1/WNT9A/ATP6V1G1/FZD6/WNT10A/CAB39L/ULK2/WNT11/RPS6KA3/FZD5/RNF152/LRP5/STRADA/TTI1/SKP2/AKT3/CHUK/PIK3R2/PIK3CB/WNT7B/RPTOR/PIK3R3/PRR5L/CASTOR2	6.20858828638891
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	56/2390	110/9376	1.99717002662609	ID4/ID1/SMAD7/ID3/MYC/TGIF1/SKI/THBS1/SKIL/SMAD4/SMAD6/SMURF2/TGFB2/PPP2CB/TFRC/TGFBR1/ACVR1B/TGFB3/SKP1/BMP2/GDF5/RPS6KB1/SMAD3/SMAD2/ID2/BMPR1A/GDF6/PITX2/PPP2R1B/FMOD/LEMD3/ZFYVE16/ZFYVE9/MAPK1/CUL1/SIN3A/BAMBI/CREBBP/BMP6/SMURF1/PPP2CA/TGFBR2/IGSF1/CDKN2B/ACVR2B/RBL1/AMH/ACVR1/BMP7/TFDP1/E2F5/SMAD1/INHBB/FST/BMP4/NEO1	6.15303957640035
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	43/2390	77/9376	2.19077324349291	STAT1/VEGFA/SMAD4/AKT1/GADD45A/GADD45B/POLK/CDKN1A/ARHGEF6/TGFB2/RAF1/BRAF/MAPK8/TGFBR1/STAT3/TGFB3/RPS6KB1/SMAD3/SMAD2/RB1/MAP2K1/PIK3CA/RELA/PLD1/MAPK1/GADD45G/ARAF/MAPK9/TGFBR2/RALA/AKT2/NFKB1/DDB2/CDKN2A/CASP9/AKT3/CDC42/CHUK/PIK3R2/PIK3CB/PIK3R3/E2F1/MAPK10	6.13658288248369
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	49/2390	93/9376	2.06696360282539	NFKBIA/MYC/CYCS/AKT1/GADD45A/GADD45B/POLK/CDKN1A/PTK2/RB1/BIRC2/CASP3/PIK3CA/RELA/TRAF6/MAX/APAF1/LAMA5/LAMC3/COL4A1/ITGA3/RARB/CDK2/GADD45G/TRAF4/XIAP/PTEN/CKS2/CDKN2B/RXRA/AKT2/ITGAV/CKS1B/NFKB1/TRAF5/DDB2/BCL2/CASP9/COL4A2/ZBTB17/SKP2/AKT3/CHUK/PIK3R2/PIK3CB/TRAF3/PTGS2/PIK3R3/E2F1	6.0480754688944
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	95/2390	227/9376	1.64178939413489	VEGFA/NFKBIA/PTGER2/MYC/ARHGEF11/FAS/CTNNB1/RHEB/IL10RB/ADCY9/CYCS/TAP2/AKT1/TBK1/PPP3CC/TAP1/CDKN1A/SOS2/RAF1/GNAI1/CGAS/PTK2/PLCB1/ATF2/TSC2/STAT3/TSC1/MAPK14/RPS6KB1/RB1/MAP2K1/MDM2/SOS1/BCAR1/CASP3/PIK3CA/RELA/PRKCA/PXN/PPP3R1/GNA12/GNB5/GNA13/CREB3L2/PPP3CB/HLA-F/GNG12/ARHGEF12/PPP3CA/GNAI3/MAPK1/TNFRSF1A/GNB2/ATF4/GNB1/GNB4/GNG5/CRKL/IL1R1/PLCB3/PDGFRA/AKT2/ITGAV/IL6/ARHGEF1/ADCY3/GNGT1/RIPK1/NFKB1/NFATC3/TRAF5/GNA11/CREB5/CDKN2A/CALR/CASP9/ADCY6/ITPR3/CASP8/GNAS/AKT3/AKAP13/CALM2/CHUK/ITGB3/PIK3R2/MAPK13/PIK3CB/MAPK12/PTGS2/PIK3R3/E2F1/CREB3L4/ELK1/B2M	5.72517740635365
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	51/2390	101/9376	1.98092713036994	STAT1/EGR1/JUN/SERPINE1/VEGFA/PIM1/PLCG2/STAT5B/SMAD4/AKT1/TGFB2/MAPK8/PLCB1/TGFBR1/STAT3/PRKCE/TGFB3/MAPK14/SMAD3/SMAD2/F3/CASP3/PIK3CA/RELA/PRKCA/PRKCD/MAPK1/COL4A1/JAK2/VEGFB/PLCB3/STAT5A/MAPK9/TGFBR2/AKT2/IL6/FOXO1/NFKB1/BCL2/COL4A2/AKT3/CDC42/VEGFC/PIK3R2/MAPK13/PIK3CB/MAPK12/NOX4/PIK3R3/MAPK10/AGER	5.79709973464711
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	71/2390	158/9376	1.76287272919867	WEE1/MYC/CCNH/SMAD4/GADD45A/ABL1/GADD45B/CDKN1C/CDKN1A/TGFB2/PPP2CB/ORC4/STAG1/TGFB3/SKP1/SMAD3/SMAD2/RB1/MDM2/ATM/CDKN2D/PDS5A/CDC16/MAU2/BUB3/CCND3/ORC2/PPP2R1B/ANAPC10/ANAPC1/YWHAG/ANAPC16/CDC26/CDK2/GADD45G/CUL1/RBL2/WAPL/CREBBP/ESCO1/ORC3/PPP2CA/YWHAQ/CDKN2B/RBL1/MAD2L1BP/PPP2R5A/STAG2/ANAPC4/PDS5B/ATR/CDKN2A/TFDP1/PPP2R5E/CDC23/CDC14B/CDK7/ZBTB17/SKP2/E2F5/NIPBL/CCNA2/ANAPC7/HDAC8/YWHAZ/CDC14A/CHEK2/ORC5/E2F1/PPP2R5B/CDK1	5.65630187850176
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	128/2390	333/9376	1.50794476484853	MX2/MX1/ISG15/STAT1/HES1/EIF2AK2/VEGFA/HES4/STAT2/MAML2/IRF9/FAS/THBS1/CTNNB1/RHEB/IRF1/AKT1/TBK1/LLGL2/CDKN1A/SOS2/RAF1/OASL/PPP2CB/PTK2/LLGL1/PPP2R2D/TSC2/TSC1/RPS6KB1/DVL1/RB1/MAP2K1/MDM2/SOS1/TBPL1/PPP2R2A/NOTCH2/ATM/AXIN2/CSNK1A1/CASP3/PIK3CA/PSEN1/MAML1/COL6A3/RELA/PDGFRB/FZD2/PXN/ITGA1/HEYL/AXIN1/PPP2R3C/CCND3/CREB3L2/HLA-F/FZD7/PPP2R1B/DVL2/PARD3/UBE3A/LAMA5/LAMC3/MAPK1/COL4A1/ITGA3/TNFRSF1A/CDK2/RBL2/COL6A6/PTEN/ATP6V1E2/CREBBP/PATJ/PPP2CA/TCF7L2/WNT2B/ATP6V0A2/DLG1/AKT2/ITGAV/WNT6/RBL1/PRKCI/MAGI1/FZD1/FOXO1/ITGA11/NFKB1/WNT9A/PPP2R5A/ATP6V1G1/NOTCH1/FZD6/WNT10A/ATR/CREB5/TICAM1/WNT11/PPP2R5E/IFNAR1/FZD5/ITGA9/PARD6G/PPP2R3A/THBS3/JAG1/COL4A2/CASP8/GNAS/THBS2/AKT3/PPP2R3B/CDC42/CHUK/CCNA2/ITGB3/PIK3R2/PIK3CB/TNC/TRAF3/WNT7B/PTGS2/PIK3R3/E2F1/CREB3L4/PPP2R5B	5.5201723569699
Human Diseases	Infectious disease: viral	hsa05162	Measles	63/2390	136/9376	1.81727787349249	MX2/MX1/OAS1/OAS2/IRF7/OAS3/STAT1/EIF2AK2/JUN/FOS/NFKBIA/STAT2/HSPA1B/IFIH1/IRF9/FAS/STAT5B/RCHY1/ADAR/CYCS/AKT1/TBK1/RAB9A/BBC3/MAPK8/EIF2S1/STAT3/CBLB/CASP3/PIK3CA/CSNK2A1/RELA/TRAF6/CCND3/MAP3K7/APAF1/CSNK2B/HSPA1A/CSNK2A2/IRAK4/CDK2/HSPA8/TAB2/STAT5A/MAPK9/CD46/MYD88/AKT2/JAK3/IL6/NFKB1/BCL2/IFNAR1/CASP9/CASP8/AKT3/CHUK/PIK3R2/PIK3CB/TRAF3/PIK3R3/MAPK10/TNFAIP3	5.61530703684368
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	69/2390	156/9376	1.73517862890248	MX2/MX1/OAS1/IFIT1/OAS2/IRF7/OAS3/SOCS3/STAT1/EIF2AK2/NFKBIA/STAT2/MYC/IRF9/FAS/CTNNB1/CYCS/AKT1/TBK1/CDKN1A/SOS2/RAF1/BRAF/PPP2CB/PPP2R2D/EIF2S1/STAT3/RB1/MAP2K1/SOS1/CLDN23/PPP2R2A/CASP3/PIK3CA/RELA/TRAF6/RNASEL/PPP2R1B/RSAD2/APAF1/YWHAG/MAPK1/TNFRSF1A/CDK2/ARAF/PPP2CA/PPARA/YWHAQ/RXRA/AKT2/RIPK1/NFKB1/LDLR/TICAM1/IFNAR1/CLDN15/CASP9/OCLN/CLDN12/CASP8/AKT3/CHUK/CXCL10/PIK3R2/PIK3CB/YWHAZ/TRAF3/PIK3R3/E2F1	5.41576748615454
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	58/2390	125/9376	1.82027782426778	CERS2/AKT1/RAF1/GNAI1/SPTLC1/PPP2CB/PPP2R2D/MAPK8/PLCB1/DEGS1/PRKCE/MAPK14/CERS6/MAP2K1/CERS5/PPP2R2A/FYN/PIK3CA/RELA/PRKCA/PLD1/GNA12/PPP2R3C/GNA13/PPP2R1B/GNAI3/MAPK1/SGPL1/TNFRSF1A/PTEN/PLCB3/S1PR3/MAPK9/PPP2CA/SGPP1/PDPK1/AKT2/GAB2/SPTSSA/NFKB1/PPP2R5A/NSMAF/BCL2/SGMS1/PPP2R5E/PPP2R3A/MAP3K5/AKT3/PPP2R3B/PIK3R2/MAPK13/PIK3CB/MAPK12/S1PR5/PIK3R3/MAPK10/PPP2R5B/ADORA1	5.39997730854355
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	99/2390	248/9376	1.56604130112026	RHOB/JUN/FOS/NFKBIA/MYC/TUBB2A/CTNNB1/CYCS/AKT1/TUBB4B/ELMO1/NOD1/RAF1/RAB9A/KLC1/ARF1/MAPK8/KPNA4/CASP1/SKP1/NCKAP1/MAPK14/RAB5A/ABI1/MAP2K1/EXOC5/DYNLT3/BIRC2/ACTR10/CASP3/CASP7/CASP4/PIK3CA/CYTH2/RELA/SNX9/DCTN6/AHNAK2/TRAF6/TXN/ARL8A/MAP3K7/TAB3/PIK3C2A/MAPK1/TNFRSF1A/IRAK4/SNX18/DNM2/CSE1L/DYNC2LI1/ARL8B/ARPC1A/TAB2/DYNC2H1/MAPK9/ACBD3/TCF7L2/MYD88/RALA/AKT2/IL6/DYNLL1/DYNC1LI2/MAP2K4/DYNLT1/ARHGEF26/PLEKHM2/KLC4/RIPK1/MYO6/NFKB1/MYL12A/SNX33/RRAS/PLEKHM1/KLC2/KPNA1/BCL2/FYCO1/GCC2/DYNC1I1/LEF1/CASP8/FBXO22/AKT3/CYTH3/CDC42/CHUK/ACTB/MAPK13/TNFRSF10B/PIK3CB/VPS33A/MAPK12/TUBB2B/TAB1/MAPK10/MYL12B	5.28392255079277
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	79/2390	187/9376	1.65731546327165	OAS1/OAS2/IRF7/OAS3/STAT1/JUN/NFKBIA/STAT2/NEK7/IRF9/GABARAPL1/NLRP1/GBP1/TBK1/TANK/NOD1/ATG12/SUGT1/MAPK8/PLCB1/CASP1/TRPM7/PKN2/MAPK14/BIRC2/ERBIN/CASP4/RELA/MAP1LC3C/PRKCD/TRAF6/IFI16/TXN/RNASEL/TRIP6/MAP3K7/DNM1L/ANTXR1/GBP3/TAB3/MAPK1/IRAK4/MAP1LC3B/ATG5/VDAC1/TAB2/XIAP/PLCB3/MAPK9/VDAC2/MFN1/MCU/MYD88/SHARPIN/GABARAPL2/NAMPT/IL6/ATG16L1/TP53BP1/RIPK1/MFN2/NFKB1/TRAF5/BCL2/TICAM1/GBP4/IFNAR1/ITPR3/CASP8/CHUK/PANX1/MAPK13/MAPK12/TRAF3/TAB1/MAPK10/TNFAIP3/AIM2/CXCL1	5.31044389245651
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	76/2390	178/9376	1.67499412345447	JUN/TLE4/MYC/SIRT1/PRICKLE2/CSNK1E/SMAD4/CTNNB1/CTBP2/PPP3CC/CACYBP/RYK/CAMK2D/SIAH1/MAPK8/PLCB1/CTBP1/SKP1/DVL1/INVS/SMAD3/MCC/LZTS2/AXIN2/CSNK1A1/TLE2/TLE1/DAAM2/PSEN1/CSNK2A1/FZD2/PRKCA/PPP3R1/AXIN1/TBL1XR1/CCND3/BTRC/PPP3CB/FZD7/MAP3K7/DVL2/PPP3CA/CSNK2B/CSNK2A2/CUL1/ROR2/BAMBI/CREBBP/PLCB3/MAPK9/TCF7L2/WNT2B/TBL1X/WNT6/FZD1/NFATC3/WNT9A/PPARD/SENP2/FZD6/DAAM1/WNT10A/NKD1/WNT11/FZD5/LEF1/APCDD1/SFRP1/LRP5/DKK1/LGR4/NKD2/WNT7B/MAPK10/NLK/CTNND2	5.31781945341823
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	45/2390	90/9376	1.96150627615063	IRS2/SIRT1/RHEB/ADCY9/AKT1/SESN1/IGF1R/INSR/IRS1/ADIPOR1/ATF2/TSC2/ULK1/EIF4E/TSC1/RPS6KB1/PIK3CA/STK11/PRKAG2/RELA/PRKAA1/CREB3L2/SOD2/ATG5/ATF4/EHMT1/AKT2/ADCY3/ATG101/FOXO1/NFKB1/ATG13/ADIPOR2/RB1CC1/CREB5/PRKAB1/FOXO3/ADCY6/AKT3/PIK3R2/PIK3CB/PRKAB2/RPTOR/PIK3R3/CREB3L4	5.36079668638448
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	33/2390	59/9376	2.19422735976172	MYC/CTNNB1/AKT1/GADD45A/GADD45B/POLK/CDKN1A/SOS2/RAF1/BRAF/MAP2K1/SOS1/AXIN2/PIK3CA/AXIN1/MLH1/MAPK1/GADD45G/ARAF/PTEN/TCF7L2/PDPK1/CTNNA1/AKT2/DDB2/LEF1/CASP9/FOXO3/AKT3/PIK3R2/PIK3CB/PIK3R3/ELK1	5.38201957181653
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	56/2390	122/9376	1.80072707318746	SOCS1/SOCS3/JUNB/STAT1/IRS2/IGFBP3/FOS/PLCG2/STAT5B/ADCY9/AKT1/SOS2/RAF1/GNAI1/IRS1/PTK2/MAPK8/PLCB1/ATF2/SHC2/STAT3/MAPK14/MAP2K1/SOS1/BCAR1/PIK3CA/PRKCA/CREB3L2/GNAI3/MAPK1/JAK2/ATF4/CRKL/CREBBP/PLCB3/STAT5A/MAPK9/SOCS2/AKT2/MAP2K4/ADCY3/GNA11/CREB5/MAP3K1/SSTR2/ADCY6/ITPR3/GNAS/AKT3/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/CREB3L4/MAPK10	5.2067889961971
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	39/2390	75/9376	2.03996652719665	IGFBP3/SERPINE1/FAS/RCHY1/THBS1/CYCS/GADD45A/MDM4/GADD45B/SESN1/CDKN1A/SIAH1/BBC3/PPP1R13L/TSC2/MDM2/PPM1D/ATM/CASP3/CCND3/APAF1/CCNG1/CDK2/SHISA5/CCNG2/GADD45G/RRM2B/PTEN/COP1/GORAB/DDB2/ATR/BCL2/CDKN2A/CASP9/CASP8/TNFRSF10B/CHEK2/CDK1	5.28877959614446
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	49/2390	103/9376	1.86628752488118	JUN/FOS/SERPINE1/NFKBIA/FAS/AKT1/IFNGR2/TGFB2/GNAI1/PPP2CB/IFNGR1/PPP2R2D/MAPK8/PLCB1/TGFBR1/TGFB3/MAPK14/SMAD2/PPP2R2A/PIK3CA/RELA/TRAF6/PPP2R1B/GNAI3/MAPK1/TNFRSF1A/IRAK4/PLCB3/MAPK9/PPP2CA/TGFBR2/MYD88/AKT2/IL6/MAP2K4/NFKB1/GNA11/TICAM1/CALR/CASP8/GNAS/AKT3/CHUK/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10	5.17059879689519
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	51/2390	109/9376	1.83553798318683	SOCS3/IRS2/NFKBIA/GFPT2/OGT/PPP1CB/AKT1/TRIB3/INSR/IRS1/MAPK8/CRTC2/STAT3/PRKCE/RPS6KB1/PPP1R3B/PIK3CA/PRKAG2/RELA/PRKCD/PRKAA1/CREB3L2/GFPT1/OGA/NR1H2/TNFRSF1A/MLX/PTEN/MAPK9/PDPK1/PPARA/PPP1R3C/AKT2/IL6/FOXO1/NFKB1/CREB5/RPS6KA3/PRKAB1/CPT1B/SREBF1/PPP1R3E/ACACB/AKT3/PIK3R2/PIK3CB/PRKAB2/PIK3R3/CREB3L4/MAPK10/GYS1	5.13192337165459
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	45/2390	93/9376	1.89823188014577	SMAD4/CTNNB1/BAIAP2/SMURF2/IGF1R/INSR/TGFBR1/SMAD3/FYN/CSNK2A1/RAP1A/MAP3K7/AFDN/PARD3/CSNK2B/CSNK2A2/ACP1/MAPK1/NECTIN3/CTNND1/CREBBP/SMURF1/TCF7L2/TGFBR2/RAP1B/FER/CTNNA1/FGFR1/ACTN1/HEG1/ACTN4/MYL12A/FARP2/WASF1/YES1/VCL/LEF1/NECTIN1/SORBS1/PTPRM/CDC42/ACTB/RADIL/NLK/MYL12B	5.09162091874802
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	49/2390	105/9376	1.83073919107392	STAT1/JUN/KSR1/NFKBIA/STAT2/PLCG2/IRF9/IRF1/AKT1/PPP3CC/RAF1/MAPK8/CASP1/CBLB/MAPK14/MDM2/BCL10/NFKB2/PIK3CA/RELA/PPP3R1/PRKCD/PPP3CB/ARHGEF12/RRAS2/PLK3/PPP3CA/MAPK1/MALT1/MAPK9/AKT2/IL6/CYLD/NFKB1/NFATC3/RRAS/RELB/ITPR3/CASP8/AKT3/CALM2/CHUK/PIK3R2/MAPK13/PIK3CB/MAPK12/PTGS2/PIK3R3/MAPK10	5.00687047182989
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	48/2390	103/9376	1.8282000243734	EIF4A3/DAZAP1/DDX39B/SMG1/PPP1CB/MSI2/NXT1/NXF1/PABPN1/PPP2CB/PAPOLA/PPP2R2D/RNPS1/PCF11/TARDBP/PELO/PPP2R2A/RNMT/WDR33/CPSF6/PPP2R3C/SMG7/CPSF7/PPP2R1B/ACIN1/MAGOH/HBS1L/UPF1/ALYREF/MAGOHB/PPP2CA/FUS/DDX19A/PAPOLG/FIP1L1/NUDT21/PPP2R5A/CSTF1/SMG6/PPP2R5E/PABPC4L/PPP2R3A/NCBP2/RNGTT/CPSF4/PPP2R3B/NXT2/PPP2R5B	4.94326644055163
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	39/2390	78/9376	1.96150627615063	TOB1/BTG2/PAN3/PNPT1/MPHOSPH6/PFKP/DDX6/CNOT2/BTG3/TENT4B/CNOT8/HSPA9/XRN1/DCP1A/BTG1/C1D/PATL1/CNOT6/ENO2/DCP2/TOB2/TENT4A/LSM8/LSM1/CNOT9/CNOT4/EXOSC6/CNOT10/EXOSC3/CNOT1/PAN2/ZCCHC7/MTREX/LSM6/EXOSC10/EXOSC9/PABPC4L/EXOSC1/DCP1B	4.98740862328045
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	74/2390	180/9376	1.6127940492794	OAS1/OAS2/IRF7/OAS3/SOCS3/STAT1/EIF2AK2/NFKBIA/SRSF6/STAT2/IFIH1/SRSF7/IRF9/FAS/BST2/PPP1CB/SP100/RHEB/CYCS/TAP2/ZC3HAV1/AKT1/IFNGR2/SRSF3/TBK1/SRSF1/TAP1/NXF1/PML/CGAS/SRSF5/IFNGR1/EIF2S1/TSC2/TSC1/SRSF9/BIRC2/CASP3/PIK3CA/EIF2B1/RELA/SRSF2/TRAF6/HLA-F/RNASEL/MAP3K7/APAF1/JAK2/TNFRSF1A/IRAK4/TAB2/ALYREF/MYD88/AKT2/IL6/EIF2B2/NFKB1/TRAF5/BCL2/TICAM1/CALR/IFNAR1/CASP9/NECTIN1/CASP8/AKT3/CHUK/ITGB3/PIK3R2/PIK3CB/TRAF3/TAB1/PIK3R3/B2M	4.85536192776615
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	85/2390	214/9376	1.55820592030657	JUN/FOS/NFKBIA/WEE1/PLCG2/FAS/BST2/CYCS/TAP2/AKT1/TBK1/PPP3CC/TAP1/RAF1/GNAI1/CGAS/PTK2/AP1G1/MAPK8/CFL2/SKP1/MAPK14/RPS6KB1/MAP2K1/ATM/CASP3/ELOC/CUL4A/PIK3CA/RELA/PRKCA/PXN/PPP3R1/TRAF6/GNB5/BTRC/PPP3CB/HLA-F/GNG12/MAP3K7/PPP3CA/CUL5/GNAI3/MAPK1/TNFRSF1A/GNB2/IRAK4/TRIM5/CUL1/GNB1/GNB4/TAB2/GNG5/CRKL/MAPK9/MYD88/AKT2/LIMK1/GNGT1/RIPK1/NFKB1/NFATC3/TRAF5/GNA11/ATR/BCL2/CALR/CASP9/CUL4B/ITPR3/CASP8/AKT3/AP1G2/CALM2/CHUK/DCAF1/PIK3R2/MAPK13/PIK3CB/MAPK12/TAB1/PIK3R3/MAPK10/CDK1/B2M	4.83143876189789
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	82/2390	205/9376	1.5692050209205	OAS1/OAS2/IRF7/ISG15/OAS3/STAT1/HES1/EIF2AK2/JUN/NFKBIA/STAT2/SAP30/PLCG2/MYC/IRF9/FAS/CYCS/TAP2/AKT1/GADD45A/GADD45B/TBK1/POLK/TAP1/CDKN1A/MAPK8/STAT3/MAPK14/RB1/MDM2/NFKB2/NEDD4/CASP3/PIK3CA/RELA/PSMD11/PSMC6/TRAF6/CCND3/HLA-F/MAP3K7/APAF1/IRAK4/CDK2/GADD45G/SIN3A/TAB2/MAPK9/BCL2L11/MYD88/AKT2/JAK3/IL6/MAP2K4/RIPK1/CD58/NFKB1/VIM/TRAF5/DDB2/BCL2/CALR/IFNAR1/CASP9/RELB/SKP2/CASP8/AKT3/CHUK/CCNA2/CXCL10/PIK3R2/MAPK13/PIK3CB/MAPK12/TRAF3/TAB1/PIK3R3/E2F1/MAPK10/TNFAIP3/B2M	4.81956236210214
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	97/2390	253/9376	1.50407991135661	JUN/NFKBIA/PLCG2/UBE2V1/CYCS/BNIP3/AKT1/TBK1/ELMO1/NOD1/CGAS/PTK2/UBE2N/ATG12/ARF1/MAPK8/PLCB1/CASP1/PRKCE/SKP1/MAPK14/RPS6KB1/MDM2/TNIP1/UBE2D1/BCL10/ATM/UBE2D3/BCAR1/CASP4/PIK3CA/CYTH2/GLMN/RELA/MAP1LC3C/PXN/CALCOCO2/CTTN/UBE2V2/PRKCD/TRAF6/HK2/GSK3A/BTRC/MAP3K7/TAB3/MAPK1/CAPN2/TNFRSF1A/MAP1LC3B/PPID/ATG5/CUL1/VDAC1/MALT1/ARPC1A/TAB2/CRKL/IL1R1/RRAGB/PLCB3/MAPK9/MYD88/SHARPIN/AKT2/ATG16L1/ARHGEF2/RIPK1/ACTN1/ACTN4/FOXO1/NFKB1/MYL12A/SQSTM1/TRAF5/FNBP1L/BCL2/WASF1/WIPI1/VCL/FOXO3/ITPR3/AKT3/CYTH3/PIK3R4/CDC42/CHUK/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/RPTOR/TAB1/PIK3R3/MAPK10/MYL12B	4.75402117080491
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	63/2390	148/9376	1.66993101888499	HES1/JUN/FOS/MYC/DLL4/CTNNB1/AKT1/GADD45A/GADD45B/POLK/CDKN1A/SOS2/IGF1R/RAF1/BRAF/SHC2/RPS6KB1/DVL1/NCOA3/RB1/MAP2K1/SOS1/NFKB2/NOTCH2/AXIN2/FGF2/CSNK1A1/PIK3CA/FZD2/HEYL/AXIN1/FZD7/DVL2/MAPK1/GADD45G/ARAF/PTEN/TCF7L2/WNT2B/FGF10/AKT2/NCOA1/WNT6/FGFR1/FZD1/WNT9A/NOTCH1/FZD6/DDB2/WNT10A/WNT11/FZD5/LEF1/LRP5/FGF22/JAG1/AKT3/ESR2/PIK3R2/PIK3CB/WNT7B/PIK3R3/E2F1	4.80482361757861
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	36/2390	71/9376	1.9891331251105	SOCS1/SOCS3/STAT1/FOS/STAT5B/IRF1/AKT1/SOS2/RAF1/MAPK8/SHC2/STAT3/MAPK14/MAP2K1/SOS1/PIK3CA/RELA/CISH/MAPK1/JAK2/SOCS6/STAT5A/MAPK9/SOCS2/AKT2/NFKB1/SOCS7/FOXO3/AKT3/ESR2/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10	4.89323450866404
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	48/2390	105/9376	1.79337716676629	JUN/CCZ1/BNIP3/GABARAPL1/TBK1/SMURF2/RABGEF1/EIF2AK3/SIAH1/MAPK8/EIF2S1/AMFR/ULK1/USP15/RAB5A/CITED2/ARIH1/TBC1D15/CSNK2A1/RELA/MAP1LC3C/CALCOCO2/RHOT1/RRAS2/MTX2/CSNK2B/CSNK2A2/MAP1LC3B/ATF4/SMURF1/MAPK9/MFN1/GABARAPL2/MFN2/USP30/CCZ1B/SQSTM1/OPA1/MUL1/RRAS/MTX3/BNIP3L/FOXO3/HIF1A/AMBRA1/E2F1/PGAM5/MAPK10	4.78168930993979
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	39/2390	80/9376	1.91246861924686	VEGFA/PLCG2/PDGFA/AXL/AKT1/SOS2/IGF1R/RAF1/BRAF/GAS6/SHC2/STAT3/EIF4E/RPS6KB1/MAP2K1/SOS1/FGF2/PIK3CA/PDGFRB/PRKCA/NF1/FGFR2/MAPK1/JAK2/ARAF/PTEN/FGFR3/PDGFRA/BCL2L11/AKT2/IL6/PDGFC/BCL2/FOXO3/AKT3/PIK3R2/NRG2/PIK3CB/PIK3R3	4.79385806611585
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	63/2390	150/9376	1.64766527196653	MYC/SMAD4/CTNNB1/AKT1/GADD45A/GADD45B/POLK/CDKN1A/SOS2/TGFB2/RAF1/BRAF/TGFBR1/SHC2/TGFB3/RPS6KB1/DVL1/SMAD3/SMAD2/RB1/MAP2K1/SOS1/AXIN2/FGF2/CSNK1A1/PIK3CA/FZD2/AXIN1/FZD7/DVL2/FGFR2/MLH1/MAPK1/RARB/CDK2/GADD45G/ARAF/TCF7L2/TGFBR2/WNT2B/FGF10/CDKN2B/RXRA/CTNNA1/AKT2/WNT6/FZD1/WNT9A/FZD6/DDB2/WNT10A/BCL2/WNT11/FZD5/LEF1/LRP5/FGF22/AKT3/PIK3R2/PIK3CB/WNT7B/PIK3R3/E2F1	4.6769186197215
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	59/2390	138/9376	1.67723000424474	SOCS1/SOCS3/IRS2/MKNK2/PPP1CB/RHEB/AKT1/SOS2/RAF1/INSR/IRS1/BRAF/MAPK8/SHC2/TSC2/EIF4E/CBLB/TSC1/TRIP10/RPS6KB1/PPP1R3B/MAP2K1/SOS1/PIK3CA/PHKG1/PRKAG2/HK2/PRKAA1/MAPK1/ARAF/CRKL/RHOQ/MAPK9/SOCS2/PDPK1/PPP1R3C/AKT2/PRKCI/PHKB/FOXO1/PRKAR1A/PRKAB1/ACACA/SREBF1/SORBS1/PPP1R3E/ACACB/PPP1R3F/AKT3/CALM2/PHKA2/PIK3R2/PIK3CB/PRKAB2/RPTOR/PIK3R3/MAPK10/GYS1/ELK1	4.68767024187878
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	65/2390	157/9376	1.62417717133491	SOCS3/IRS2/COX7A1/JUN/FOS/XBP1/FAS/CYCS/AKT1/ITCH/INSR/IRS1/EIF2AK3/SDHA/SDHD/ADIPOR1/MAPK8/SDHB/EIF2S1/NDUFC2/MAPK14/NDUFA13/ERN1/CASP3/CASP7/PIK3CA/NDUFS4/PRKAG2/RELA/PRKAA1/NDUFV3/UQCRC2/GSK3A/NDUFA7/NDUFA5/NDUFB5/LEPR/TNFRSF1A/DDIT3/ATF4/NDUFB3/MLX/MAPK9/PPARA/BCL2L11/RXRA/AKT2/IL6/NFKB1/ADIPOR2/NDUFA4L2/PRKAB1/MAP3K5/SREBF1/CASP8/AKT3/CDC42/PIK3R2/MAPK13/PIK3CB/PRKAB2/MAPK12/PIK3R3/COX6B2/MAPK10	4.61302807206537
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	84/2390	216/9376	1.5256159925616	IRF7/JUN/FOS/XBP1/NFKBIA/HSPA1B/FAS/HSPA2/CYCS/AKT1/TBK1/TANK/PPP3CC/ERO1A/CAMK2D/PTK2/EIF2AK3/MAPK8/PLCB1/EIF2S1/CASP1/STAT3/MAPK14/ABCA1/ERN1/CASP3/CASP7/PIK3CA/VAV2/RELA/PRKCA/PPP3R1/TRAF6/RAP1A/PPP3CB/MAP3K7/SOD2/PPP3CA/APAF1/HSPA1A/MAPK1/JAK2/TNFRSF1A/DDIT3/IRAK4/ATF4/HSPA8/TAB2/PLCB3/MAPK9/PDPK1/RAP1B/MYD88/RXRA/AKT2/IL6/MAP2K4/ARHGEF1/NFKB1/NFATC3/BCL2/MIB2/LDLR/TICAM1/CASP9/MAP3K5/CASP8/AKT3/CALM2/CDC42/CHUK/HSPA5/PIK3R2/MAPK13/TNFRSF10B/PIK3CB/MAPK12/TRAF3/TAB1/PIK3R3/OLR1/MAPK10/AGER/CXCL1	4.57107142622946
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	36/2390	73/9376	1.93463632716226	PLCG2/STAT5B/AKT1/GADD45A/GADD45B/POLK/CDKN1A/SOS2/RAF1/BRAF/STAT3/RB1/MAP2K1/SOS1/PIK3CA/PRKCA/MAPK1/RARB/GADD45G/ARAF/STAT5A/PDPK1/RXRA/AKT2/JAK3/DDB2/CDKN2A/CASP9/RET/FOXO3/EML4/AKT3/PIK3R2/PIK3CB/PIK3R3/E2F1	4.68881259153531
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	77/2390	196/9376	1.54118350268978	ZFP36/IRF7/STAT1/EIF2AK2/JUN/FOS/VEGFA/NFKBIA/STAT2/PLCG2/MYC/IRF9/FAS/CTNNB1/CYCS/AKT1/TBK1/PPP3CC/CDKN1A/RAF1/IFNGR1/MAPK8/STAT3/MAPK14/RB1/MAP2K1/RCAN1/FGF2/CASP3/PIK3CA/RELA/MAP1LC3C/PPP3R1/GNB5/PPP3CB/HLA-F/GNG12/PPP3CA/MAPK1/JAK2/TNFRSF1A/GNB2/MAP1LC3B/GNB1/GNB4/GNG5/CREBBP/MAPK9/TCF7L2/AKT2/IL6/MAP2K4/GNGT1/NFKB1/NFATC3/TICAM1/MICA/IFNAR1/LEF1/CASP9/HIF1A/CLEC2B/ITPR3/CASP8/AKT3/CALM2/CHUK/PIK3R2/MAPK13/PIK3CB/MAPK12/TRAF3/PTGS2/PIK3R3/E2F1/MAPK10/CXCL1	4.47838619420084
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	52/2390	120/9376	1.69997210599721	JUN/NFKBIA/PLCG2/ZNF274/AKT1/ABL1/SOS2/RAF1/IRS1/BRAF/CAMK2D/MAPK8/SHC2/MAPK14/MAP2K1/SOS1/PIK3CA/PSEN1/RELA/PRKCD/IRAK3/TRAF6/RAP1A/FRS2/MAPK7/MAPK1/IRAK4/ATF4/CRKL/MAPK9/PDPK1/RAP1B/AKT2/NFKB1/SH2B1/BCL2/MAP3K1/RPS6KA3/MAP3K5/FOXO3/AKT3/CALM2/NTF3/CDC42/ARHGDIG/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10/NGF	4.51367184615749
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	59/2390	142/9376	1.62998408863221	SOCS1/SOCS3/JUNB/STAT1/JUN/FOS/NFKBIA/JUND/STAT2/FOSB/PLCG2/IRF9/FOSL2/AKT1/IFNGR2/PPP3CC/TGFB2/FHL2/IFNGR1/MAPK8/TGFBR1/MAPK14/MAP2K1/NFKB2/FYN/PIK3CA/RELA/CSF1/PPP3R1/TRAF6/PPP3CB/MAP3K7/PPP3CA/TMEM64/MAPK1/TNFRSF1A/ATP2A2/TAB2/IL1R1/MAPK9/TGFBR2/AKT2/GAB2/CYLD/NFKB1/SQSTM1/IFNAR1/RELB/ITPR3/AKT3/CHUK/ITGB3/PIK3R2/MAPK13/PIK3CB/MAPK12/TAB1/PIK3R3/MAPK10	4.4243463339686
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	55/2390	130/9376	1.65973607981976	JUN/FOS/VEGFA/NFKBIA/ADCY9/AKT1/SOS2/RAF1/GNAI1/MAPK8/PLCB1/ATF2/TGFBR1/SHC2/MAPK14/SMAD2/MAP2K1/SOS1/PIK3CA/RELA/PRKCA/GNB5/CREB3L2/GNG12/GNAI3/MAPK1/COL4A1/GNB2/ATF4/GNB1/GNB4/GNG5/VEGFB/PLCB3/MAPK9/TGFBR2/AKT2/MAP2K4/ADCY3/GNGT1/NFKB1/CREB5/EDNRB/ADCY6/COL4A2/GNAS/AKT3/VEGFC/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/CREB3L4/MAPK10	4.43032172315379
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	35/2390	72/9376	1.907019990702	IRF7/ISG15/NFKBIA/IFIH1/ADAR/DHX58/TBK1/TANK/AZI2/DDX3X/TRIM25/ATG12/MAPK8/CASP10/MAPK14/RELA/TRAF6/OTUD5/MAP3K7/ZNFX1/SIKE1/ATG5/MAPK9/RIPK1/CYLD/NFKB1/MAP3K1/CASP8/CHUK/TBKBP1/CXCL10/MAPK13/MAPK12/TRAF3/MAPK10	4.51875249452202
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	69/2390	173/9376	1.56466974629356	MX2/MX1/OAS1/OAS2/IRF7/OAS3/SOCS3/STAT1/EIF2AK2/NFKBIA/STAT2/IFIH1/IRF9/FAS/ADAR/CYCS/NXT1/AKT1/IFNGR2/TBK1/NXF1/RAF1/PML/PABPN1/NUP98/TRIM25/IFNGR1/EIF2S1/CASP1/MAP2K1/XPO1/CASP3/PIK3CA/KPNA5/RELA/PRKCA/CALCOCO2/CCND3/RNASEL/RSAD2/APAF1/MAPK1/JAK2/TNFRSF1A/IRAK4/VDAC1/CREBBP/MYD88/AKT2/IL6/DNAJB1/NFKB1/KPNA2/KPNA1/TICAM1/IFNAR1/CASP9/CASP8/CPSF4/AKT3/CHUK/ACTB/CXCL10/PIK3R2/TNFRSF10B/PIK3CB/TRAF3/PIK3R3/NXT2	4.38453113542047
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	37/2390	78/9376	1.86091621070701	PLCG2/IP6K3/MINPP1/PLCB1/MTMR3/PIK3CA/MTMR2/SACM1L/PIKFYVE/IMPA1/IP6K1/PIK3C2A/IPMK/PIP5K1A/PPIP5K2/ALDH6A1/PTEN/INPP1/PI4KB/INPP5E/PLCB3/PI4KA/IMPA2/MTMR4/INPP5B/PIP4K2A/PIP4K2C/INPP4A/ITPKA/PIK3CB/IPPK/MTMR1/INPP5F/PI4K2A/PLCH2/OCRL/PI4K2B	4.46564004802128
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	93/2390	250/9376	1.45936066945607	HSPA1B/RAB11FIP3/GRK5/WASHC1/ARF4/ITCH/SMURF2/IGF1R/PML/CHMP5/PDCD6IP/SPART/RUFY2/ARF1/ARAP1/TFRC/TGFBR1/WASHC4/SNX3/CAPZA1/CBLB/RAB5A/ARFGAP3/SMAD3/SMAD2/MDM2/LDLRAP1/EPN2/EPS15L1/NEDD4/IST1/SNX1/CYTH2/PLD1/RAB8A/TSG101/WASHC2A/ARFGEF1/CAPZA2/TRAF6/EPS15/VPS29/AP2A1/HLA-F/STAM2/PARD3/ASAP1/VPS37A/ZFYVE16/FGFR2/HSPA1A/ZFYVE9/PIP5K1A/DNM2/ARFGEF2/HSPA8/ARPC1A/CAV2/VPS26A/RNF41/GBF1/SMURF1/RAB35/FGFR3/TGFBR2/PDGFRA/CHMP7/STAM/PRKCI/ACAP2/FGFR4/AGAP1/ARFGAP1/ASAP2/ACAP3/STAMBP/LDLR/RAB22A/WASHC3/AGAP4/RAB11FIP5/PARD6G/DNM1/ASAP3/AGAP6/ARAP3/CYTH3/CDC42/ZFYVE27/AGAP9/GRK4/PSD/RAB11FIP4	4.30580024585053
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	52/2390	122/9376	1.67210371081693	JUN/FOS/NFKBIA/MAP3K8/AKT1/PPP3CC/SOS2/RAF1/PPP2CB/NCK1/PPP2R2D/MAPK8/CBLB/MAPK14/MAP2K1/SOS1/BCL10/PPP2R2A/FYN/PIK3CA/NCK2/VAV2/RELA/PPP3R1/PPP2R3C/PPP3CB/MAP3K7/PPP2R1B/PPP3CA/MAPK1/MALT1/MAPK9/PPP2CA/PDPK1/DLG1/AKT2/NFKB1/NFATC3/PPP2R5A/PPP2R5E/PPP2R3A/AKT3/PPP2R3B/CDC42/CHUK/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10/PPP2R5B	4.37040575118102
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	52/2390	122/9376	1.67210371081693	STAT1/PLCG2/MYC/CTNNB1/ATP1B1/RHEB/MED13L/AKT1/THRB/PFKP/RAF1/PLCB1/MED30/TSC2/GATA4/NCOA3/MAP2K1/MDM2/NOTCH2/NCOA2/RCAN1/PIK3CA/MED13/PRKCA/MAPK1/MED17/ATP2A2/SIN3A/CREBBP/PLCB3/KAT2B/PDPK1/MED4/RXRA/AKT2/NCOA1/ITGAV/MED14/KAT2A/FOXO1/NOTCH1/DIO3/HDAC3/CASP9/HIF1A/AKT3/ITGB3/ACTB/PIK3R2/PIK3CB/PIK3R3/BMP4	4.37040575118102
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	41/2390	90/9376	1.78715016271502	STAT1/JUN/FOS/NFKBIA/AKT1/IFNGR2/PPP3CC/RAF1/IFNGR1/STAT3/MAPK14/RPS6KB1/MAP2K1/PIK3CA/CSNK2A1/RELA/BATF3/PPP3R1/TRAF6/PPP3CB/BATF2/PPP3CA/CSNK2B/CSNK2A2/MAPK1/JAK2/PTEN/MYD88/AKT2/NFKB1/NFATC3/TICAM1/HIF1A/EML4/AKT3/CHUK/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3	4.38868896505113
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	67/2390	170/9376	1.5461284764952	PLCG2/MYC/ARID1B/SMAD4/CTNNB1/AKT1/GADD45A/GADD45B/GSTT2B/POLK/CDKN1A/SOS2/IGF1R/TGFB2/RAF1/BRAF/TGFBR1/SHC2/PHF10/TGFB3/RPS6KB1/DVL1/SMAD3/SMAD2/RB1/MAP2K1/SOS1/AXIN2/ARID2/CSNK1A1/PIK3CA/FZD2/PRKCA/AXIN1/FZD7/DVL2/MAPK1/GADD45G/ARAF/PTEN/SMARCE1/BRD7/TCF7L2/TGFBR2/WNT2B/AKT2/WNT6/SMARCD3/FZD1/WNT9A/FZD6/DDB2/WNT10A/CDKN2A/WNT11/ACTL6A/FZD5/LEF1/LRP5/AKT3/ACTB/PIK3R2/PIK3CB/WNT7B/PIK3R3/E2F1/ELK1	4.20294876377286
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	46/2390	106/9376	1.70243940948922	NFKBIA/PDGFA/CTNNB1/AKT1/CDKN1A/SOS2/IGF1R/RAF1/BRAF/NKX3-1/RB1/MAP2K1/MDM2/SOS1/PIK3CA/RELA/PDGFRB/CREB3L2/FGFR2/MAPK1/CDK2/ARAF/ATF4/PTEN/CREBBP/TCF7L2/PDPK1/PDGFRA/AKT2/PLAU/FGFR1/FOXO1/NFKB1/PDGFC/BCL2/CREB5/LEF1/CASP9/AKT3/PLAT/CHUK/PIK3R2/PIK3CB/PIK3R3/E2F1/CREB3L4	4.25394854760841
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	133/2390	388/9376	1.34474399344347	PSMA2/IRS2/COX7A1/EIF2AK2/XBP1/FAS/TUBB2A/CSNK1E/CTNNB1/CYCS/AKT1/SLC39A14/TUBB4B/PPP3CC/PSMD9/SLC39A13/RAF1/INSR/IRS1/BRAF/EIF2AK3/SDHA/SDHD/KLC1/MAPK8/PLCB1/SDHB/EIF2S1/ULK1/NDUFC2/PSMA3/DVL1/NDUFA13/MAP2K1/ERN1/AXIN2/CSNK1A1/CASP3/CASP7/PIK3CA/PSEN1/NDUFS4/CSNK2A1/RELA/PSMD11/FZD2/CSF1/PSMC6/PPP3R1/AXIN1/NAE1/NDUFV3/UQCRC2/NDUFA7/NDUFA5/PPP3CB/NDUFB5/FZD7/DVL2/PPP3CA/APAF1/CSNK2B/CSNK2A2/MAPK1/CAPN2/ADAM10/TNFRSF1A/DDIT3/PSMB2/PPID/ARAF/ATF4/VDAC1/ATP2A2/NDUFB3/PSMA6/ADAM17/SLC11A2/PLCB3/MAPK9/VDAC2/NCSTN/WNT2B/MCU/BACE2/ATP5F1C/RTN3/AKT2/WNT6/IL6/MME/ATG101/KLC4/FZD1/NFKB1/WNT9A/ATG13/SLC39A6/ATG2B/FZD6/KLC2/RB1CC1/WNT10A/ULK2/WNT11/NDUFA4L2/WIPI1/FZD5/CASP9/MAPT/MAP3K5/AMBRA1/LRP5/DKK1/ITPR3/CASP8/AKT3/LRP1/RYR3/PIK3R4/CALM2/SLC39A10/CHUK/PIK3R2/PIK3CB/TUBB2B/WNT7B/PTGS2/NOX4/PIK3R3/COX6B2/MAPK10/AGER	4.056498661802
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	58/2390	144/9376	1.58010227801023	TRA2A/NFKBIA/SIRT1/FAS/CTNNB1/LPIN1/AKT1/TBK1/ADIPOR1/MAPK8/MAPK14/CASP3/PRKAG2/RELA/TRAF6/PRKAA1/ACADVL/LPIN3/MAP3K7/TAB3/TNFRSF1A/IRAK4/TAB2/MAPK9/TCF7L2/PPARA/MYD88/AKT2/IL6/MAP2K4/RIPK1/FOXO1/NFKB1/ADIPOR2/TICAM1/LEF1/PRKAB1/IL17RC/MAP3K5/CPT1B/FOXO3/ACACA/SREBF1/ACOX3/ACACB/CASP8/TRA2B/AKT3/CHUK/MAPK13/PRKAB2/MAPK12/TRAF3/ADH1B/NOX4/TAB1/MAPK10/CXCL1	4.10306329977378
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	77/2390	204/9376	1.48074493395685	VEGFA/DDX5/PLCG2/MYC/FAS/THBS1/PPP1CB/CTNNB1/AKT1/HOXD10/CDKN1A/SOS2/IGF1R/TGFB2/RAF1/BRAF/CAMK2D/PTK2/TIMP3/STAT3/MAPK14/RPS6KB1/TFAP4/SMAD2/MAP2K1/MDM2/SOS1/HSPB2/TWIST1/FGF2/CASP3/PIK3CA/VAV2/FZD2/PRKCA/PXN/CTTN/FRS2/FZD7/ARHGEF12/RRAS2/PPP1R12B/MAPK1/ARAF/CAV2/HSPG2/SDC4/PDPK1/WNT2B/AKT2/PLAU/ITGAV/WNT6/ARHGEF1/ANK3/FGFR1/SDC2/FZD1/WNT9A/RRAS/FZD6/WNT10A/WNT11/FZD5/HIF1A/ITPR3/AKT3/CDC42/ITGB3/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/WNT7B/PIK3R3/ELK1	4.06039304390622
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	33/2390	70/9376	1.84942020322773	JUN/VEGFA/FLCN/AKT1/CDKN1A/SOS2/TGFB2/EGLN3/RAF1/BRAF/ARNT/TGFB3/MAP2K1/SOS1/EGLN1/ELOC/PIK3CA/RAP1A/MAPK1/ARAF/CRKL/PRCC/CREBBP/RAP1B/AKT2/VHL/HIF1A/FH/AKT3/CDC42/PIK3R2/PIK3CB/PIK3R3	4.17215447862593
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	30/2390	62/9376	1.89823188014577	HES1/TLE4/MAML2/DTX3L/DLL4/CTBP2/ITCH/ATXN1/CTBP1/NUMB/DVL1/SPEN/NOTCH2/TLE2/TLE1/PSEN1/MAML1/HEYL/ATXN1L/DTX3/DVL2/NUMBL/ADAM17/CREBBP/KAT2B/NCSTN/KAT2A/NOTCH1/JAG1/DTX2	4.15036690161605
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	14/2390	21/9376	2.61534170153417	CHSY1/CHST3/XYLT1/CSGALNACT2/XYLT2/CHST14/CHST12/DSE/CHST15/DSEL/CHPF2/CHST7/CSGALNACT1/B4GALT7	4.33433479615941
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	124/2390	362/9376	1.34379435493192	VEGFA/DDIT4/PDGFA/MYC/NR4A1/THBS1/RHEB/AKT1/EPOR/CDKN1A/SOS2/IGF1R/RAF1/IL4R/INSR/IRS1/PPP2CB/PTK2/PPP2R2D/ATF2/CRTC2/MCL1/TSC2/EIF4E/PKN2/TSC1/RPS6KB1/MAP2K1/MDM2/SOS1/PPP2R2A/FGF2/PIK3CA/GDNF/STK11/COL6A3/RELA/PDGFRB/PRKCA/CSF1/OSMR/ITGA1/PPP2R3C/PRKAA1/CCND3/GNB5/CREB3L2/GNG12/PPP2R1B/LAMA5/FGFR2/YWHAG/LAMC3/MAPK1/COL4A1/JAK2/ITGA3/GNB2/CDK2/ATF4/GNB1/RBL2/GNB4/LPAR1/PHLPP2/GNG5/COL6A6/PTEN/VEGFB/FGFR3/PPP2CA/PDPK1/PDGFRA/FGF10/YWHAQ/BCL2L11/RXRA/AKT2/JAK3/ITGAV/FLT3LG/IL6/MAGI1/GNGT1/FGFR4/FGFR1/ITGA11/NFKB1/PPP2R5A/PDGFC/KITLG/MAGI2/BCL2/CREB5/PPP2R5E/EPHA2/IFNAR1/ITGA9/CASP9/PPP2R3A/RET/FOXO3/EFNA5/FGF22/THBS3/COL4A2/THBS2/AKT3/PPP2R3B/NTF3/CHUK/ITGB3/VEGFC/PHLPP1/PIK3R2/PIK3CB/YWHAZ/TNC/RPTOR/PIK3R3/CREB3L4/GYS1/NGF/PPP2R5B	3.90179589752927
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	22/2390	41/9376	2.10503112562506	POLD4/UIMC1/ATM/RAD52/RAD50/TOP3B/ABRAXAS1/RPA4/TOP3A/MUS81/RAD51B/POLD3/BABAM2/MRE11/RAD51C/RAD51D/TOPBP1/SYCP3/POLD1/RAD54B/PALB2/BARD1	4.14743488492691
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	55/2390	137/9376	1.5749320465443	JUN/FOS/NFKBIA/FAS/CYCS/AKT1/GADD45A/GADD45B/RAF1/EIF2AK3/BBC3/LMNA/MAPK8/EIF2S1/MCL1/CASP10/MAP2K1/ATM/ERN1/BIRC2/CASP3/CASP7/PIK3CA/RELA/APAF1/MAPK1/CAPN2/TNFRSF1A/DDIT3/GADD45G/ATF4/XIAP/MAPK9/PDPK1/BCL2L11/AKT2/RIPK1/NFKB1/PARP4/BCL2/CASP9/MAP3K5/ITPR3/DAB2IP/CASP8/AKT3/CHUK/ACTB/PIK3R2/TNFRSF10B/PIK3CB/PIK3R3/DFFB/MAPK10/NGF	3.96492169638087
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	30/2390	63/9376	1.86810121538155	GTF2H2/GTF2H2C/POLD4/CCNH/POLR2M/POLR2C/POLR2A/CUL4A/RAD23B/POLR2K/RAD23A/POLR2J3/POLR2B/GTF2H5/POLE/RPA4/POLR2H/MNAT1/ERCC6/POLR2D/UVSSA/DDB2/ERCC5/GTF2H1/POLD3/CUL4B/CDK7/ERCC4/RFC4/POLD1	4.04358089119806
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	30/2390	63/9376	1.86810121538155	CTNNB1/PTCH2/GADD45A/GADD45B/POLK/CDKN1A/BMP2/DVL1/AXIN2/FZD2/AXIN1/FZD7/DVL2/GLI2/GADD45G/TCF7L2/WNT2B/WNT6/FZD1/WNT9A/GLI3/FZD6/DDB2/WNT10A/KIF7/WNT11/FZD5/LEF1/WNT7B/BMP4	4.04358089119806
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	42/2390	98/9376	1.6812910938434	PLCG2/IP6K3/PLCB1/MTMR3/PIK3CA/MTMR2/SACM1L/PIKFYVE/PRKCA/IMPA1/IP6K1/PIK3C2A/IPMK/PIP5K1A/PPIP5K2/PIP4P2/PTEN/INPP1/PI4KB/INPP5E/PLCB3/PI4KA/IMPA2/MTMR4/INPP5B/DGKD/PIP4K2A/CDS2/PIP4K2C/INPP4A/ITPKA/ITPR3/CALM2/PIK3R2/PIK3CB/IPPK/MTMR1/PIK3R3/INPP5F/PI4K2A/OCRL/PI4K2B	3.96541699403524
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	78/2390	212/9376	1.44337254282782	VEGFA/ID1/PDGFA/THBS1/CTNNB1/ADCY9/AKT1/PRKD3/IGF1R/RAF1/GNAI1/INSR/BRAF/PLCB1/MAPK14/MAP2K1/FGF2/BCAR1/PIK3CA/VAV2/PDGFRB/PRKCA/CSF1/RAP1A/AFDN/PARD3/FGFR2/GNAI3/MAPK1/LPAR1/CRKL/CTNND1/RAPGEF2/VEGFB/PLCB3/FGFR3/PDGFRA/FGF10/RAP1B/RALA/AKT2/PRKCI/MAGI1/ADCY3/FGFR4/MAGI3/FGFR1/RRAS/FARP2/PDGFC/KITLG/MAGI2/ENAH/ADORA2B/EPHA2/PARD6G/RAPGEF3/EFNA5/FGF22/PRKD1/ADCY6/GNAS/ARAP3/AKT3/RAP1GAP/CALM2/CDC42/ITGB3/VEGFC/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/NGF/RAPGEF6/DOCK4	3.81913036236981
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	42/2390	99/9376	1.66430835552174	JUN/FOS/DLL4/ADCY9/AKT1/CDKN1A/SOS2/IGF1R/RAF1/BRAF/PTK2/MAPK8/SHC2/MAPK14/RPS6KB1/NCOA3/RB1/MAP2K1/MDM2/SOS1/NOTCH2/PIK3CA/MAPK1/ARAF/MAPK9/AKT2/ADCY3/NOTCH1/BCL2/CDKN2A/JAG1/ADCY6/GNAS/AKT3/ESR2/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/E2F1/MAPK10	3.88645668634716
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	157/2390	480/9376	1.2831520223152	PSMA2/COX7A1/XBP1/FAS/ATXN2L/TUBB2A/CSNK1E/CTNNB1/CYCS/TUBB4B/TBK1/TANK/PPP3CC/PSMD9/RAF1/ATXN1/BRAF/CAMK2D/EIF2AK3/SDHA/SDHD/KLC1/MAPK8/PLCB1/SDHB/EIF2S1/UBE2L6/ULK1/TARDBP/NDUFC2/SPG11/MAPK14/PRNP/RAB5A/PSMA3/DVL1/NDUFA13/MAP2K1/ERN1/AXIN2/ACTR10/CSNK1A1/CASP3/CASP7/PSEN1/NDUFS4/CSNK2A1/RELA/PSMD11/MAP1LC3C/FZD2/PRKCA/CSF1/RAB8A/RAB1A/PSMC6/PPP3R1/DCTN6/DLG4/AXIN1/ATXN1L/NDUFV3/UQCRC2/NDUFA7/NDUFA5/PPP3CB/NDUFB5/UBE2J2/FZD7/DVL2/PPP3CA/APAF1/CSNK2B/CSNK2A2/MAPK1/CAPN2/TNFRSF1A/DDIT3/DERL1/ATXN3/PSMB2/MAP1LC3B/PPID/ARAF/TRAP1/ATF4/VDAC1/ATP2A2/NDUFB3/PSMA6/PLCB3/UBE2G1/MAPK9/VDAC2/MFN1/FUS/WNT2B/MCU/ATP5F1C/UBE2J1/WNT6/IL6/ATXN2/ATG101/KLC4/MFN2/FZD1/IFT57/NFKB1/SQSTM1/WNT9A/ATG13/GPX8/ATG2B/VAPB/FZD6/KLC2/RB1CC1/WNT10A/BCL2/ULK2/WNT11/NDUFA4L2/WIPI1/C9orf72/FZD5/ZFYVE1/CASP9/MAPT/MAP3K5/AMBRA1/LRP5/NEFM/DKK1/ITPR3/CASP8/RYR3/PIK3R4/CALM2/MAP3K10/HSPA5/ALS2/MAPK13/WDR41/MAPK12/TUBB2B/WNT7B/PTGS2/DNAL4/NOX4/COX6B2/MAPK10/DNAL1/AGER/DNAH9/RYR2/PRPH	3.7248878152297
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	27/2390	56/9376	1.89145248057382	NFKBIA/CLK1/HSPA1B/SEC22B/CYCS/BNIP3/CLK4/SAR1B/ARF1/CASP1/NFKB2/CASP3/CASP7/SAR1A/RELA/RAB1A/HSF1/APAF1/HSPA1A/HBS1L/HSPA8/MYD88/IL6/NFKB1/CASP9/CASP8/CXCL1	3.91340281564324
Human Diseases	Cancer: specific types	hsa05214	Glioma	34/2390	76/9376	1.75503193129267	PLCG2/PDGFA/AKT1/GADD45A/GADD45B/POLK/CDKN1A/SOS2/IGF1R/RAF1/BRAF/CAMK2D/SHC2/RB1/MAP2K1/MDM2/SOS1/PIK3CA/PDGFRB/PRKCA/MAPK1/GADD45G/ARAF/PTEN/PDGFRA/AKT2/DDB2/CDKN2A/AKT3/CALM2/PIK3R2/PIK3CB/PIK3R3/E2F1	3.86545782170404
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	46/2390	112/9376	1.61123729826659	SOCS1/STAT1/NFKBIA/HSPA1B/IL10RB/CYCS/AKT1/IFNGR2/TGFB2/GNAI1/IFNGR1/MAPK8/STAT3/TGFB3/MAPK14/BIRC2/CASP3/RELA/TRAF6/MAP3K7/LAMA5/GNAI3/LAMC3/HSPA1A/MAPK1/JAK2/TNFRSF1A/IRAK4/HSPA8/TAB2/XIAP/MAPK9/PDPK1/MYD88/AKT2/NFKB1/BCL2/LDLR/CASP9/CASP8/AKT3/CHUK/MAPK13/MAPK12/TAB1/MAPK10	3.80618491414911
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	124/2390	368/9376	1.32188466436238	PSMA2/COX7A1/XBP1/SRSF7/ATXN2L/TUBB2A/NUP160/CYCS/HNRNPA2B1/NXT1/TUBB4B/SRSF3/TBK1/NUP58/TANK/PPP3CC/PSMD9/NXF1/NUP98/UBQLN1/EIF2AK3/SDHA/SDHD/KLC1/NUP153/SDHB/EIF2S1/CASP1/ULK1/TARDBP/NDUFC2/SPG11/ANG/MAPK14/RAB5A/PSMA3/NDUFA13/ERN1/ACTR10/CASP3/NDUFS4/PSMD11/MAP1LC3C/RAB8A/RAB1A/PSMC6/PPP3R1/NUP155/DCTN6/NUP54/NDUFV3/UQCRC2/NDUFA7/NDUFA5/PPP3CB/NDUFB5/PPP3CA/APAF1/TNFRSF1A/POM121C/DDIT3/DERL1/PSMB2/MAP1LC3B/ATF4/VDAC1/NDUFB3/ALYREF/PSMA6/FUS/MCU/ATP5F1C/SEC13/SETX/NUP93/SEH1L/HNRNPA3/NUP85/ATXN2/ATG101/KLC4/RANBP2/NUP188/NUP50/SQSTM1/HDAC6/ATG13/GPX8/ATG2B/VAPB/NUP107/KLC2/RB1CC1/BCL2/NUP205/ULK2/NDUFA4L2/WIPI1/C9orf72/CASP9/NUP88/MAP3K5/AMBRA1/HNRNPA1/NEFM/ITPR3/NUP35/PIK3R4/NUP43/ACTB/HSPA5/ALS2/NRG2/MAPK13/WDR41/MAPK12/TUBB2B/DNAL4/COX6B2/DNAL1/NXT2/NDC1/DNAH9/PRPH	3.68451479350771
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	29/2390	62/9376	1.83495748414091	IRS2/HSPA1B/SIRT1/ADCY9/AKT1/IGF1R/INSR/IRS1/RPS6KB1/PIK3CA/PRKAG2/CRYAB/PRKAA1/SOD2/HSPA1A/ATG5/HSPA8/AKT2/ADCY3/FOXO1/PRKAB1/FOXO3/ADCY6/AKT3/PIK3R2/PIK3CB/PRKAB2/RPTOR/PIK3R3	3.85800146157434
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	31/2390	68/9376	1.78843219296087	PIM1/MYC/RARA/STAT5B/AKT1/SOS2/RAF1/ZBTB16/PML/BRAF/STAT3/RPS6KB1/MAP2K1/SOS1/PIK3CA/RELA/MAPK1/ARAF/STAT5A/TCF7L2/AKT2/NFKB1/PPARD/PER2/LEF1/AKT3/CHUK/CCNA2/PIK3R2/PIK3CB/PIK3R3	3.8164617667454
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	37/2390	86/9376	1.68780772599008	JUN/PLCG2/MYC/STAT5B/AKT1/ABL1/CDKN1A/SOS2/RAF1/BRAF/CAMK2D/PTK2/NCK1/MAPK8/SHC2/CBLB/RPS6KB1/MAP2K1/SOS1/PIK3CA/NCK2/PRKCA/MAPK1/BTC/ARAF/CRKL/STAT5A/MAPK9/AKT2/MAP2K4/AKT3/PIK3R2/NRG2/PIK3CB/PIK3R3/MAPK10/ELK1	3.74781993129239
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	74/2390	203/9376	1.43006368901622	JUN/VEGFA/PDGFA/EMP1/THBS1/PPP1CB/CTNNB1/AKT1/SOS2/IGF1R/RAF1/BRAF/PTK2/EMP2/MAPK8/SHC2/MAP2K1/SOS1/FYN/BIRC2/BCAR1/PIK3CA/VAV2/COL6A3/PDGFRB/PRKCA/PXN/ITGA1/CCND3/RAP1A/PPP1R12B/LAMA5/LAMC3/MAPK1/CAPN2/COL4A1/PIP5K1A/ITGA3/XIAP/COL6A6/PTEN/CAV2/CRKL/VEGFB/MAPK9/PDPK1/PDGFRA/RAP1B/AKT2/ITGAV/ACTN1/ACTN4/ITGA11/MYL12A/PDGFC/BCL2/ITGA9/VCL/THBS3/COL4A2/THBS2/AKT3/CDC42/ARHGAP5/ITGB3/VEGFC/ACTB/PIK3R2/PIK3CB/TNC/PIK3R3/MAPK10/ELK1/MYL12B	3.6232257662385
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	52/2390	133/9376	1.53380941894485	FOS/PPP1CB/AKT1/PPP3CC/GNAI1/CAMK2D/PPP2CB/COMT/PPP2R2D/MAPK8/PLCB1/ATF2/MAPK14/PPP2R2A/PRKCA/PPP2R3C/GNB5/GSK3A/CREB3L2/PPP3CB/GNG12/PPP2R1B/PPP3CA/GNAI3/GNB2/ATF4/GNB1/GNB4/GNG5/PLCB3/MAPK9/PPP2CA/AKT2/GNGT1/CACNA1A/PPP2R5A/CREB5/CLOCK/PPP2R5E/PPP2R3A/ITPR3/GNAS/AKT3/PPP2R3B/CALM2/MAPK13/MAPK12/MAOB/CREB3L4/MAPK10/LRTOMT/PPP2R5B	3.62640140685289
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	33/2390	75/9376	1.72612552301255	FAS/CYCS/AKT1/GSTT2B/CDKN1A/BBC3/MDM2/ATM/BIRC2/CASP3/PIK3CA/APAF1/MLH1/MAPK1/MSH6/XIAP/PDPK1/AKT2/REV3L/ATP7B/BCL2/CDKN2A/TOP2B/CASP9/MAP3K5/CASP8/AKT3/POLH/PIK3R2/PIK3CB/MSH3/MSH2/PIK3R3	3.69273216965984
Human Diseases	Cancer: specific types	hsa05218	Melanoma	32/2390	73/9376	1.71967673525534	PDGFA/AKT1/GADD45A/GADD45B/POLK/CDKN1A/IGF1R/RAF1/BRAF/RB1/MAP2K1/MDM2/FGF2/PIK3CA/PDGFRB/MAPK1/GADD45G/ARAF/PTEN/PDGFRA/FGF10/AKT2/FGFR1/PDGFC/DDB2/CDKN2A/FGF22/AKT3/PIK3R2/PIK3CB/PIK3R3/E2F1	3.61041962529501
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	55/2390	144/9376	1.49837284983728	PSMA2/XBP1/ATXN2L/CYCS/AKT1/PSMD9/GTF2B/ATXN1/MAPK8/PLCB1/ULK1/PSMA3/PUM2/OMA1/TBPL1/ERN1/PIK3CA/PSMD11/PRKCA/PSMC6/ATXN1L/PUM1/NOP56/ATXN10/MYOD1/ATXN3/PSMB2/NFYA/VDAC1/ATP2A2/PSMA6/PLCB3/MAPK9/VDAC2/MCU/AKT2/ATXN2/ATG101/OPA1/ATG13/CACNA1A/ATG2B/RB1CC1/ULK2/WIPI1/MAP3K5/AMBRA1/ITPR3/RORA/AKT3/PIK3R4/PIK3R2/PIK3CB/PIK3R3/MAPK10	3.52499107016949
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	59/2390	157/9376	1.47425312475015	CEBPB/DUSP8/PTGER2/SIRT1/THBS1/AXL/DUSP7/EPOR/ELMO1/ODC1/CAMK2D/PTK2/ARNT/DUSP5/GAS6/CASP1/MAPK14/RAB5A/ABCA1/MAP2K1/BCAR1/ATP11A/CASP3/CASP7/CD47/ADAM9/GULP1/NR1H2/MAPK1/ADAM10/JAK2/PBX1/ATP2A2/ATP11B/CRKL/ADAM17/VPS8/PROS1/DUSP16/RXRA/ITGAV/TGFBRAP1/NFATC3/MFGE8/RAB14/PPARD/CALR/CPT1B/HIF1A/LRP1/TYRO3/SLC16A1/ITGB3/PANX1/MAPK13/VPS33A/MAPK12/PTGS2/AGER	3.50500319173528
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	72/2390	200/9376	1.41228451882845	JUN/FOS/NFKBIA/ARHGEF11/FAS/SEC24D/TUBB2A/CYCS/ABL1/TUBB4B/SEC24A/BAIAP2/NCK1/ARF1/MAPK8/CASP1/NCKAP1/MAPK14/ABI1/CLDN23/FYN/CASP3/CASP7/CASP4/CYTH2/NCK2/RELA/RAB1A/CTTN/GNA12/TRAF6/GNA13/ARHGEF12/MAP3K7/SEC24C/TAB3/MAPK1/SEC24B/TNFRSF1A/IRAK4/ARPC1A/LPAR1/TAB2/IL1R1/MAPK9/MYD88/IL6/ARHGEF1/ARHGEF2/RIPK1/MYO6/NFKB1/BAIAP2L1/WASF1/CLDN15/CASP9/MYO1E/OCLN/CLDN12/CASP8/CYTH3/CDC42/CHUK/ACTB/MAPK13/TNFRSF10B/MAPK12/TUBB2B/MYH9/TAB1/MAPK10/TMBIM6	3.44711379852033
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	42/2390	105/9376	1.5692050209205	NFKBIA/PLCG2/GADD45A/GADD45B/TRIM25/PPP1R13L/BCL10/NFKB2/ATM/BIRC2/CSNK2A1/RELA/TRAF6/MAP3K7/TAB3/UBE2I/CSNK2B/CSNK2A2/TNFRSF1A/IRAK4/GADD45G/MALT1/TAB2/XIAP/IL1R1/MYD88/PLAU/RIPK1/CYLD/NFKB1/ERC1/TRAF5/BCL2/TICAM1/CCL13/RELB/CHUK/TRAF3/PTGS2/TAB1/TNFAIP3/CXCL1	3.43060233859918
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	40/2390	99/9376	1.58505557668738	JUN/FOS/PLA2G4A/PDGFA/SLC22A3/RHEB/AKT1/SOS2/RAF1/SLC44A1/MAPK8/CHPT1/TSC2/TSC1/RPS6KB1/MAP2K1/SOS1/PIK3CA/PDGFRB/PRKCA/PLD1/MAPK1/PIP5K1A/CHKA/CHKB/MAPK9/PDPK1/PDGFRA/AKT2/DGKD/PLPP3/PDGFC/WASF1/HIF1A/AKT3/SLC22A5/PIK3R2/PIK3CB/PIK3R3/MAPK10	3.42279777004388
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	27/2390	60/9376	1.76535564853556	VEGFA/PLA2G4A/PLCG2/AKT1/PPP3CC/RAF1/PTK2/SHC2/MAPK14/MAP2K1/PIK3CA/PRKCA/PXN/PPP3R1/PPP3CB/PPP3CA/MAPK1/AKT2/CASP9/AKT3/CDC42/PIK3R2/MAPK13/PIK3CB/MAPK12/PTGS2/PIK3R3	3.47851976240397
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	45/2390	115/9376	1.5350918682918	EGR1/FOS/JUND/ARHGEF11/PDE4D/ADCY9/CDKN1A/RAF1/GNAI1/BRAF/MEF2D/PLCB1/ATF2/RUNX2/OXSR1/MAP2K1/MMP14/PRKCA/PLD1/GNA12/GNA13/CREB3L2/GNAI3/MAPK1/ARAF/ATF4/PLCB3/RXRA/MEF2A/ARHGEF1/ADCY3/PTH1R/FGFR1/VDR/WNK1/GNA11/BCL2/CREB5/LRP5/ADCY6/ITPR3/GNAS/AKAP13/CREB3L4/MMP16	3.37690332124182
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	38/2390	94/9376	1.58589869135583	CEBPB/JUN/FOS/NFKBIA/JUND/FOSB/TBK1/SRSF1/USP25/MAPK8/MAPK14/TRAF3IP2/CASP3/MAPK6/RELA/TRAF6/ELAVL1/MAPK7/MAP3K7/TAB3/MAPK1/TRAF4/TAB2/MAPK9/IL6/NFKB1/TRAF5/IL17RC/CASP8/CHUK/CXCL10/MAPK13/MAPK12/TRAF3/PTGS2/MAPK10/TNFAIP3/CXCL1	3.33915032341205
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	53/2390	142/9376	1.464222994873	DUSP1/JUN/FOS/VEGFA/KLF2/PDGFA/CTNNB1/AKT1/GSTT2B/PTK2/MAPK8/MAPK14/SUMO1/PIK3CA/RELA/BMPR1A/PRKAA1/TXN/MAPK7/MAP3K7/TNFRSF1A/SUMO4/CAV2/IL1R1/MAPK9/SDC4/MEF2A/AKT2/ACVR2B/ITGAV/MAP2K4/ARHGEF2/SDC2/NFKB1/SQSTM1/ACVR1/BCL2/SUMO2/MAP3K5/NPPC/AKT3/CALM2/PLAT/CHUK/ITGB3/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10/BMP4	3.26021457140224
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	57/2390	155/9376	1.44265622891078	RASD1/NR4A1/AHR/CTNNB1/ADCY9/CDKN1A/GNAI1/BRAF/CAMK2D/ARNT/PLCB1/ATF2/PDE8A/DVL1/RB1/MAP2K1/AXIN2/FZD2/AXIN1/RAP1A/CREB3L2/FZD7/DVL2/WDR5/GNAI3/RBBP5/MAPK1/CDK2/PBX1/ATF4/PLCB3/TCF7L2/WNT2B/RAP1B/CDKN2B/WNT6/ADCY3/FZD1/WNT9A/FZD6/GNA11/WNT10A/CREB5/LDLR/CDKN2A/WNT11/FZD5/LEF1/FH/ADCY6/ITPR3/GNAS/MEN1/WNT7B/E2F1/KMT2D/CREB3L4	3.25022716632295
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	25/2390	56/9376	1.7513448894202	OSTC/ALG13/MOGS/MAN2A1/KRTCAP2/DHRSX/DAD1/DPM1/B4GALT1/B4GALT3/MAN1A1/RPN1/MGAT4B/MGAT2/STT3B/ALG2/ALG9/ALG8/TMEM258/DPAGT1/ALG6/ST6GAL2/B4GALT2/ALG10B/ALG10	3.29834205395169
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	42/2390	109/9376	1.51161951556562	IRF7/STAT1/JUN/FOS/NFKBIA/STAT2/IRF9/MAP3K8/AKT1/TBK1/MAPK8/MAPK14/MAP2K1/PIK3CA/RELA/TRAF6/MAP3K7/MAPK1/IRAK4/TAB2/MAPK9/TOLLIP/MYD88/AKT2/IL6/MAP2K4/RIPK1/NFKB1/TICAM1/IFNAR1/CASP8/AKT3/CHUK/CXCL10/PIK3R2/MAPK13/PIK3CB/MAPK12/TRAF3/TAB1/PIK3R3/MAPK10	3.14239711677923
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	71/2390	205/9376	1.358701908358	IRF7/GTF2H2/EIF2AK2/JUN/NFKBIA/GTF2H2C/IRF9/STAT5B/SP100/DDX3X/CDKN1A/GTF2B/ATF2/STAT3/RB1/MDM2/RASA2/TBPL1/NFKB2/CASP3/PIK3CA/RELA/PXN/CCND3/GTF2A2/CREB3L2/HLA-F/UBE3A/YWHAG/MAPK1/CDK2/ATF4/RBL2/HDAC5/CREBBP/KAT2B/STAT5A/GTF2A1/YWHAQ/DLG1/CDKN2B/JAK3/RBL1/KAT2A/ACTN1/RANBP1/ACTN4/NFKB1/HDAC6/DNAJA3/TRAF5/CREB5/GTF2H1/GTF2E2/HDAC4/CDKN2A/HDAC3/HNRNPK/SKP2/CASP8/CDC42/CCNA2/GSN/HDAC8/PIK3R2/PIK3CB/YWHAZ/TRAF3/PIK3R3/CREB3L4/CDK1	3.03719425022053
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	42/2390	110/9376	1.49787751996957	SERPINE1/VEGFA/PLCG2/ALDOA/MKNK2/AKT1/IFNGR2/PFKP/LDHA/CDKN1A/IGF1R/EGLN3/INSR/CAMK2D/ARNT/IFNGR1/TFRC/STAT3/EIF4E/RPS6KB1/MAP2K1/ENO2/EGLN1/ELOC/PIK3CA/RELA/PRKCA/HK2/PDK1/MAPK1/CREBBP/AKT2/IL6/VHL/NFKB1/BCL2/HIF1A/PFKFB3/AKT3/PIK3R2/PIK3CB/PIK3R3	3.07215419915697
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	15/2390	29/9376	2.0291444236041	LATS2/CSNK1E/TEAD1/SAV1/STK3/YAP1/WTIP/AJUBA/TEAD3/FRMD6/LATS1/MOB1A/WWTR1/NF2/MOB1B	3.2464558478817
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	41/2390	107/9376	1.50321041723693	SIRT1/AKT1/SIK1/PPP3CC/PFKP/LDHA/CAMK2D/PLCB1/ATF2/CRTC2/PPP4R3A/PHKG1/PRKAG2/PPP4R3B/PPP3R1/PPP4C/PRKAA1/CREB3L2/PPP3CB/PPP3CA/SIK2/ATF4/CREBBP/PLCB3/PPARA/AKT2/PHKB/FOXO1/CREB5/PRKAB1/CPT1B/ACACA/ACACB/ITPR3/GNAS/AKT3/CALM2/PHKA2/PRKAB2/CREB3L4/GYS1	3.06193078251853
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	16/2390	32/9376	1.96150627615063	CYCS/BBC3/MAPK8/BIRC2/CASP3/CASP7/BIRC6/APAF1/TNFRSF1A/XIAP/MAPK9/BCL2L11/BCL2/CASP9/CASP8/MAPK10	3.18662526943486
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	29/2390	70/9376	1.62524805738195	SOCS3/IRS2/NFKBIA/AKT1/IRS1/ADIPOR1/MAPK8/STAT3/STK11/PRKAG2/RELA/PRKAA1/LEPR/JAK2/TNFRSF1A/MAPK9/PPARA/RXRA/AKT2/NFKB1/ADIPOR2/PRKAB1/CPT1B/ACACB/AKT3/CHUK/PRKAB2/MAPK10/ACSL6	3.07107303657913
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	51/2390	140/9376	1.42909742976689	EGR1/SERPINE1/KLF2/SMAD4/ADCY9/AKT1/RAF1/GNAI1/MEF2D/PLCB1/TGFBR1/PRKCE/RPS6KB1/SMAD3/SMAD2/MAP2K1/NRF1/PRKAG2/MAP1LC3C/PRKAA1/GNB5/GNA13/GNG12/RRAS2/GNAI3/MAPK1/GNB2/MAP1LC3B/GNB1/HDAC5/GNB4/GNG5/PLCB3/SLC8A1/MEF2A/AKT2/ADCY3/GNGT1/RRAS/HDAC4/PRKAB1/JAG1/ADCY6/ITPR3/AKT3/RYR3/PIK3R4/CALM2/PLAT/PRKAB2/RYR2	2.99190821979762
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	80/2390	238/9376	1.3186596814458	VEGFA/KSR1/PLA2G4A/PLCG2/PDGFA/ETS2/AKT1/ABL1/TBK1/RASA3/RALGAPA1/SOS2/IGF1R/RAF1/INSR/PLA2G5/MAPK8/SHC2/RAB5A/SYNGAP1/MAP2K1/SOS1/RASA2/FGF2/PIK3CA/SHOC2/RELA/PDGFRB/PRKCA/CSF1/PLD1/GNB5/RAP1A/NF1/GNG12/RRAS2/AFDN/FGFR2/MAPK1/GNB2/GNB1/GNB4/GNG5/VEGFB/MAPK9/FGFR3/PDGFRA/FGF10/RAP1B/RALA/AKT2/RALGAPB/FLT3LG/RGL2/RASAL2/GNGT1/FGFR4/GAB2/FGFR1/NFKB1/RRAS/PDGFC/KITLG/EPHA2/EFNA5/FGF22/AKT3/CALM2/NTF3/CDC42/CHUK/VEGFC/PIK3R2/PIK3CB/PLA2G12A/RIN1/PIK3R3/MAPK10/NGF/ELK1	2.9124623331512
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	50/2390	138/9376	1.42138135952944	JUN/FOS/NFKBIA/AKT1/TBK1/ELMO1/BAIAP2/PTK2/MAPK8/CASP1/PKN2/MAPK14/MAP2K1/BCAR1/PIK3CA/VAV2/RELA/PXN/TRAF6/ARHGEF12/MAP3K7/MAPK1/ARHGEF7/PIP5K1A/IRAK4/ARPC1A/TAB2/CRKL/MAPK9/MYD88/AKT2/IL6/MAP2K4/LIMK1/ARHGEF1/NFKB1/NFATC3/TICAM1/RPS6KA3/AKT3/CDC42/CHUK/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/TAB1/PIK3R3/MAPK10	2.91672968883219
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	20/2390	44/9376	1.7831875237733	GTF2H2/GTF2H2C/CCNH/GTF2B/TBPL1/TAF7/TAF13/GTF2A2/TAF8/TAF4/GTF2H5/GTF2A1/TAF2/MNAT1/GTF2F2/TAF1/GTF2H1/GTF2E2/CDK7/TAF5L	3.04561520306075
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	36/2390	93/9376	1.51858550411661	EGR1/JUN/PLA2G4A/ADCY9/SOS2/RAF1/CAMK2D/MAPK8/PLCB1/MAPK14/MAP2K1/SOS1/MMP14/MAP3K2/PRKCA/PLD1/PRKCD/MAPK7/MAPK1/ATF4/PLCB3/MAPK9/MAP3K4/MAP2K4/ADCY3/GNA11/MAP3K1/ADCY6/ITPR3/GNAS/CALM2/CDC42/MAPK13/MAPK12/MAPK10/ELK1	2.93959818091865
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	41/2390	109/9376	1.47562857471882	STAT1/JUN/FOS/NFKBIA/RARA/STAT5B/AHR/SMAD4/IFNGR2/PPP3CC/IL4R/IL1RAP/IFNGR1/MAPK8/TGFBR1/STAT3/MAPK14/SMAD3/SMAD2/RELA/PPP3R1/PPP3CB/PPP3CA/STAT6/MAPK1/JAK2/IL1R1/STAT5A/MAPK9/TGFBR2/RXRA/JAK3/IL6/NFKB1/NFATC3/HIF1A/RORA/CHUK/MAPK13/MAPK12/MAPK10	2.9213386440153
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	41/2390	110/9376	1.4622137694941	CPEB2/ADCY9/AKT1/IGF1R/RAF1/GNAI1/BRAF/MAPK8/MAPK14/MAP2K1/PIK3CA/CDC16/ANAPC10/GNAI3/ANAPC1/ANAPC16/MAPK1/CDC26/CDK2/ARAF/MAPK9/AKT2/ADCY3/ANAPC4/RPS6KA3/CDC23/SPDYE1/ADCY6/AKT3/CCNA2/ANAPC7/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/SPDYE5/SPDYE16/MAPK10/SPDYA/CDK1	2.8520909579253
Organismal Systems	Nervous system	hsa04730	Long-term depression	25/2390	60/9376	1.63458856345886	PLA2G4A/GUCY1B1/IGF1R/RAF1/GNAI1/BRAF/PPP2CB/PLCB1/PRKG1/MAP2K1/PRKCA/GNA12/GNA13/PPP2R1B/GNAI3/MAPK1/GUCY1A2/GUCY1A1/ARAF/PLCB3/PPP2CA/CACNA1A/GNA11/ITPR3/GNAS	2.88418706154568
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	16/2390	34/9376	1.84612355402412	BHLHE40/NFIL3/CSNK1E/PER1/FBXL3/CRY1/SKP1/PRKAG2/PRKAA1/BTRC/CUL1/PER2/CLOCK/PRKAB1/RORA/PRKAB2	2.89083703559248
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	17/2390	37/9376	1.80246522673301	MYC/CTNNB1/GADD45A/GADD45B/POLK/CDKN1A/BRAF/MAP2K1/TFG/MAPK1/GADD45G/TCF7L2/CCDC6/RXRA/DDB2/LEF1/RET	2.86053452972982
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	58/2390	170/9376	1.33843957666749	YBX3/JUN/WHAMM/AMOTL2/RAP2C/F11R/LLGL2/PPP2CB/LLGL1/PPP2R2D/MAPK8/PRKCE/GATA4/CLDN23/PPP2R2A/NEDD4/STK11/PRKAG2/RAB8A/CTTN/PRKAA1/RAP1A/ARHGAP17/PPP2R1B/AFDN/PARD3/RAB8B/JAM3/ARPC1A/TJAP1/RAPGEF2/PATJ/MAPK9/PPP2CA/DLG1/PRKCI/MAGI1/ARHGEF2/ACTN1/ACTN4/MYL12A/MPDZ/MICALL2/MAP3K1/PARD6G/CLDN15/PRKAB1/MAP3K5/OCLN/CLDN12/CDC42/NF2/ACTB/PRKAB2/MYH9/MAPK10/RAPGEF6/MYL12B	2.60459628381771
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	67/2390	201/9376	1.30767085076708	NFKBIZ/CEBPB/IGFBP3/MEIS1/DDX5/PDGFA/MYC/RARA/BCL6/BMI1/SS18L1/GADD45A/KDM6A/GADD45B/POLK/CDKN1A/IGF1R/ZBTB16/PML/PTK2/SS18/RUNX2/MLLT3/HOXA9/HOXA11/MDM2/CDK14/ATM/MLF1/BIRC2/LDB1/ID2/RELA/CCNT2/AFF1/ELK4/HOXA10/MAX/DDIT3/EWSR1/PBX1/GADD45G/SIN3A/ETV6/PRCC/ETV7/FUS/TGFBR2/RXRA/PLAU/CDK9/IL6/SUPT3H/FOXO1/NFKB1/DDB2/ATF1/EYA1/PBX3/PER2/TCF3/ZBTB17/SMAD1/NSD2/PLAT/CCNA2/MEN1	2.57900178489408
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	23/2390	56/9376	1.61123729826659	GAS1/CSNK1E/PTCH2/SMURF2/SPOP/CSNK1A1/MOSMO/CUL3/BTRC/SPOPL/GLI2/CSNK1G2/CUL1/MGRN1/SMURF1/EVC2/BOC/GLI3/BCL2/KIF7/CSNK1G1/EFCAB7/EVC	2.68328129226014
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	42/2390	117/9376	1.40826091621071	MORF4L2/EPC2/ARID1B/SS18L1/DPF2/BCL7B/GATAD2B/MBD2/SS18/MEAF6/PHF10/MTA3/EPC1/GATAD2A/ARID2/INO80D/MTA1/TRRAP/BRD8/CDK2AP2/BCL7C/SMARCE1/ING3/BRD7/BICRA/BAZ2B/YY1/ACTR8/VPS72/EP400/MRGBP/SMARCD3/INO80C/INO80/MTA2/BICRAL/ACTL6A/YY2/ACTR5/INO80B/ACTB/CDK2AP1	2.59907608231461
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	25/2390	63/9376	1.55675101281796	PLOD2/DLST/KMT5A/PHYKPL/AASS/KMT2E/KMT5C/KMT2B/EHMT1/DLD/NSD1/NSD3/SETD7/ACAT1/GCDH/TMLHE/PRDM6/ASH1L/SETD2/SMYD2/SETD1A/NSD2/KMT2D/SUV39H2/CAMKMT	2.59332404643205
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	51/2390	149/9376	1.3427761085058	PLA2G4A/PLCG2/PDGFA/RHEB/ADCY9/AKT1/SOS2/RAF1/INSR/ARF1/PLCB1/SHC2/TSC2/TSC1/MAP2K1/SOS1/FYN/PIK3CA/CYTH2/PDGFRB/PRKCA/PLD1/GNA12/GNA13/RRAS2/MAPK1/PIP5K1A/DNM2/PTGFR/LPAR1/PLCB3/PDGFRA/RALA/AKT2/DGKD/PLPP3/ADCY3/GAB2/RRAS/PDGFC/KITLG/AGPAT4/RAPGEF3/DNM1/ADCY6/GNAS/AKT3/CYTH3/PIK3R2/PIK3CB/PIK3R3	2.46685552932659
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	56/2390	166/9376	1.32342592125825	IRS2/PPP1CB/ATP1B1/ADCY9/AKT1/GUCY1B1/PPP3CC/RAF1/GNAI1/INSR/IRS1/MEF2D/PLCB1/ATF2/PRKCE/PDE3A/GATA4/PRKG1/MAP2K1/PPP3R1/GNA12/KCNMA1/GNA13/CREB3L2/PPP3CB/ATP2B4/PPP3CA/GNAI3/MAPK1/GUCY1A2/GUCY1A1/ATF4/VDAC1/ATP2A2/PLCB3/VDAC2/SLC8A1/MEF2A/AKT2/ADCY3/NFATC3/KCNJ8/GNA11/CREB5/EDNRB/ADRA2C/ADCY6/ITPR3/NPPC/AKT3/CALM2/ADRA2A/CREB3L4/ADORA1/NPR2/KCNMB3	2.45906127604543
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	75/2390	232/9376	1.26821526475256	PDGFA/PPP1CB/AKT1/DIAPH2/BAIAP2/SOS2/ARHGEF6/RAF1/BRAF/PTK2/SPATA13/CFL2/NCKAP1/MAP2K1/SOS1/FGF2/BCAR1/PIK3CA/VAV2/PDGFRB/PIKFYVE/PXN/GNA12/ITGA1/GNA13/GNG12/ARHGEF12/RRAS2/PPP1R12B/ABI2/FGFR2/MAPK1/ARHGEF7/PIP5K1A/ITGA3/ARAF/ARPC1A/BDKRB1/LPAR1/CRKL/FGFR3/PDGFRA/FGF10/AKT2/ITGAV/LIMK1/ARHGEF1/FGD1/FGFR4/FGFR1/ACTN1/ACTN4/ITGA11/MYL12A/PIP4K2A/RRAS/PDGFC/ENAH/WASF1/PIP4K2C/ITGA9/VCL/FGF22/AKT3/CDC42/GSN/ITGB3/ACTB/PIK3R2/PIK3CB/C7/MYH9/PIK3R3/MYL12B/SSH3	2.41952254221572
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	16/2390	37/9376	1.6964378604546	UGP2/GFPT2/UGDH/UAP1/GALK2/HK2/PGM3/GFPT1/TGDS/PMM2/GNPNAT1/UAP1L1/GNE/PGM2/NANP/FPGT	2.48258052969111
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	36/2390	101/9376	1.39830150379055	CTNNB1/ADCY9/RAF1/GNAI1/CAMK2D/PLCB1/DVL1/MAP2K1/FZD2/PRKCA/CREB3L2/FZD7/DVL2/GNAI3/MAPK1/CREBBP/PLCB3/TCF7L2/WNT2B/WNT6/ADCY3/FZD1/WNT9A/FZD6/KITLG/WNT10A/EDNRB/WNT11/FZD5/LEF1/ADCY6/GNAS/CALM2/WNT7B/CREB3L4/MC1R	2.35388895917572
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	47/2390	138/9376	1.33609847795767	CPEB2/PPP1CB/ADCY9/PPP3CC/IGF1R/CAMK2D/PPP2CB/SKP1/MAPK14/MAP2K1/CDC16/STAG3/PPP3R1/BTRC/PPP3CB/PPP2R1B/PPP3CA/ANAPC10/ANAPC1/YWHAG/ANAPC16/MAPK1/CDC26/CDK2/CUL1/PPP2CA/YWHAQ/ADCY3/PPP2R5A/ANAPC4/PPP2R5E/RPS6KA3/CDC23/SPDYE1/REC8/ADCY6/ITPR3/CALM2/ANAPC7/MAPK13/YWHAZ/MAPK12/SPDYE5/SPDYE16/SPDYA/PPP2R5B/CDK1	2.32641617114999
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	26/2390	69/9376	1.47823661391062	PLA2G4A/PLCG2/AKT1/SOS2/RAF1/MAPK8/MAPK14/MAP2K1/SOS1/FYN/PIK3CA/VAV2/PRKCA/MAPK1/MAPK9/PDPK1/AKT2/MAP2K4/GAB2/AKT3/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10	2.33202289132895
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	11/2390	23/9376	1.87622339457886	POLD4/MLH1/PMS2/MSH6/RPA4/MLH3/POLD3/MSH3/MSH2/RFC4/POLD1	2.46078456025685
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	19/2390	47/9376	1.58589869135583	SOCS1/SOCS3/IRS2/MAFA/INSR/IRS1/MAPK8/PRKCE/PIK3CA/PRKCD/HK2/MAPK1/MAPK9/SOCS2/CACNA1A/PIK3R2/PIK3CB/PIK3R3/MAPK10	2.35518056267254
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	17/2390	41/9376	1.62661496071028	VEGFA/MYC/THBS1/CDKN1A/RAF1/BRAF/TYMP/DAPK1/RB1/MAP2K1/MDM2/MAPK1/DAPK3/ARAF/FGFR3/CDKN2A/E2F1	2.35182945276483
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	14/2390	32/9376	1.7163179916318	LDHA/SUCLA2/SUCLG2/MCEE/HIBCH/ALDH6A1/ECHDC1/DLD/PCCA/ACACA/ACOX3/ABAT/ACACB/ACSS3	2.37402195877827
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	14/2390	32/9376	1.7163179916318	GABARAPL1/PPP2CB/ATG12/ATG5/PPP2CA/GABARAPL2/ATG16L1/ATG101/ATG13/ATG2B/ULK2/WIPI1/PIK3R4/RPTOR	2.37402195877827
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	33/2390	93/9376	1.3920367121069	STAT1/JUN/FOS/NFKBIA/MAML2/STAT5B/DLL4/IFNGR2/PPP3CC/IL4R/IFNGR1/MAPK8/MAPK14/NOTCH2/MAML1/RELA/PPP3R1/PPP3CB/PPP3CA/STAT6/MAPK1/JAK2/STAT5A/MAPK9/JAK3/NFKB1/NFATC3/NOTCH1/JAG1/CHUK/MAPK13/MAPK12/MAPK10	2.22225726830886
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	55/2390	168/9376	1.28431958557482	SOCS1/SOCS3/STAT1/STAT2/PIM1/PDGFA/IL11/MYC/IRF9/STAT5B/IL10RB/AKT1/IFNGR2/EPOR/IL15RA/CDKN1A/SOS2/RAF1/IL4R/IFNGR1/MCL1/STAT3/SOS1/PIK3CA/PIAS2/PDGFRB/CLCF1/OSMR/CCND3/CISH/STAM2/STAT6/LEPR/JAK2/SOCS6/PTPN2/LIF/CREBBP/STAT5A/SOCS2/PDGFRA/IL15/AKT2/JAK3/IL6/STAM/BCL2/IFNAR1/SOCS7/AKT3/PIK3R2/PIK3CB/FHL1/CTF1/PIK3R3	2.17494891633297
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	21/2390	54/9376	1.5256159925616	HES1/POLK/WDR48/POLI/MLH1/PMS2/TOP3B/FAN1/RPA4/REV3L/ATR/TOP3A/MUS81/FANCC/FANCF/POLH/RAD51C/ERCC4/FANCL/FANCI/PALB2	2.2655893754273
Organismal Systems	Immune system	hsa04611	Platelet activation	42/2390	126/9376	1.30767085076708	PLA2G4A/PLCG2/PPP1CB/ADCY9/AKT1/GUCY1B1/GNAI1/SNAP23/PLCB1/PRKG1/MAPK14/FYN/PIK3CA/GNA13/RAP1A/ARHGEF12/PTGIR/GNAI3/MAPK1/GUCY1A2/GUCY1A1/PLCB3/RAP1B/AKT2/PRKCI/ARHGEF1/ADCY3/MYL12A/ADCY6/ITPR3/GNAS/STIM1/AKT3/ITGB3/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/ADAMTS13/MYL12B	2.03362586387144
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	31/2390	89/9376	1.36644257439707	PDGFA/TUBB2A/ADCY9/TUBB4B/GUCY1B1/SOS2/RAF1/GNAI1/PLCB1/PRKG1/MAP2K1/SOS1/PDGFRB/MAP3K2/PRKCA/MAPK7/GNAI3/MAPK1/GUCY1A2/GUCY1A1/LPAR1/PLCB3/PDGFRA/ADCY3/PDGFC/GNA11/ADCY6/ITPR3/GNAS/TUBB2B/CDK1	2.03157801373318
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	26/2390	73/9376	1.39723734739497	MX2/MX1/BST2/ELL2/PDCD6IP/NUP153/MLLT3/SERINC5/XPO1/CPSF6/CCNT2/TSG101/NELFCD/CPSF7/AFF4/TRIM5/MDFIC/TNPO3/NELFA/CREBBP/ELL/KAT2B/CDK9/KAT2A/RANBP2/BICD2	1.99283017593457
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	58/2390	184/9376	1.23660178279061	PLCG2/SEMA4C/ABL1/PPP3CC/RAF1/GNAI1/RYK/CAMK2D/PTK2/NCK1/CFL2/DPYSL2/PLXNA3/FYN/PIK3CA/NCK2/SRGAP2/PRKCA/PPP3R1/PPP3CB/ARHGEF12/PARD3/PPP3CA/GNAI3/MAPK1/SLIT2/PLXNA4/PLXNA2/PDPK1/BOC/LIMK1/SRGAP1/SEMA3G/NFATC3/MYL12A/RRAS/ENAH/EPHA5/BMP7/EPHA2/EFNB1/PARD6G/NTN1/EFNA5/EPHB4/SEMA3C/CDC42/SEMA4A/RND1/PIK3R2/PIK3CB/PLXNA1/PIK3R3/UNC5B/NEO1/SEMA4F/MYL12B/SSH3	1.89579867062092
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	17/2390	44/9376	1.5157093952073	OSTC/ST3GAL3/ALG13/MAN2A1/KRTCAP2/DAD1/B4GALT1/B4GALT3/MAN1A1/RPN1/MGAT4B/MGAT2/STT3B/ALG2/ALG9/TMEM258/B4GALT2	2.00546143385612
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	45/2390	139/9376	1.27004003491767	JUN/FOS/HSPA1B/RARA/ADCY9/AKT1/FKBP4/SOS2/RAF1/GNAI1/PLCB1/ATF2/SHC2/NCOA3/MAP2K1/SOS1/NCOA2/PIK3CA/PRKCD/CREB3L2/GNAI3/HSPA1A/MAPK1/ATF4/HSPA8/PLCB3/AKT2/NCOA1/KRT10/ADCY3/GABBR1/BCL2/CREB5/ADCY6/ITPR3/GNAS/AKT3/ESR2/CALM2/FKBP5/PIK3R2/PIK3CB/PIK3R3/CREB3L4/KRT18	1.87603260400167
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2390	38/9376	1.54855758643471	UGP2/GFPT2/UGDH/UAP1/GALK2/HK2/PGM3/GFPT1/GNPDA2/PMM2/GNPNAT1/UAP1L1/GNE/PGM2/FPGT	1.98178887979074
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	33/2390	98/9376	1.32101443087695	PLA2G4A/PLCG2/AKT1/RAF1/CFL2/PRKCE/RPS6KB1/MAP2K1/PIK3CA/VAV2/PRKCA/PLD1/PRKCD/ASAP1/MAPK1/PIP5K1A/DNM2/ARPC1A/MARCKSL1/CRKL/AKT2/LIMK1/PLPP3/GAB2/ASAP2/WASF1/ASAP3/AKT3/CDC42/GSN/PIK3R2/PIK3CB/PIK3R3	1.86844667577972
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	25/2390	71/9376	1.3813424479934	MYC/GLS/AKT1/PFKP/LDHA/RAF1/MAP2K1/PIK3CA/PDGFRB/HK2/PDK1/FGFR2/MAPK1/PTEN/SIRT6/FGFR3/PDGFRA/AKT2/FGFR1/RET/HIF1A/AKT3/PIK3R2/PIK3CB/PIK3R3	1.88649836788276
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	17/2390	45/9376	1.4820269642027	ABCA8/ABCA5/TAP2/TAP1/ABCA1/ABCC9/ABCA6/ABCD4/ABCD3/ABCB7/ABCC3/ABCB10/ABCA9/ABCC5/ABCA10/ABCC10/ABCB5	1.89576191046771
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	21/2390	59/9376	1.39632650166655	IRS2/ADCY9/AKT1/ABHD5/GNAI1/INSR/IRS1/PRKG1/PIK3CA/GNAI3/AKT2/ADCY3/ADCY6/GNAS/AKT3/PIK3R2/PIK3CB/PTGS2/TSHR/PIK3R3/ADORA1	1.78612302872088
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	13/2390	33/9376	1.54542918727019	SEC22B/STX2/BET1/SNAP23/STX5/STX7/GOSR1/GOSR2/STX16/STX11/VAMP7/VAMP4/BNIP1	1.83578775172452
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/2390	30/9376	1.5692050209205	DLST/SDHA/SDHD/SDHB/SUCLA2/SUCLG2/IDH3A/ACO1/DLD/MDH1/DLAT/FH	1.82636156632518
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	37/2390	115/9376	1.26218664726214	FOS/ADCY9/AKT1/GNAI1/CAMK2D/PLCB1/MAP2K1/FYN/PIK3CA/PRKCA/GNB5/CREB3L2/GNG12/GNAI3/MAPK1/JAK2/GNB2/ATF4/GNB1/GNB4/GNG5/PLCB3/AKT2/ADCY3/GNGT1/CACNA1A/GNA11/BCL2/CREB5/ADCY6/ITPR3/AKT3/PIK3R2/PIK3CB/KCNJ14/PIK3R3/CREB3L4	1.65462981665417
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	48/2390	154/9376	1.22275715915883	JUN/FOS/PLA2G4A/PPP1CB/ADCY9/GUCY1B1/PPP3CC/CDKN1A/RAF1/GNAI1/CAMK2D/PLCB1/MAP2K1/RCAN1/EEF2K/PRKAG2/PRKCA/PPP3R1/CACNA2D1/PRKAA1/PPP3CB/MAPK7/PPP1R12B/PPP3CA/GNAI3/MAPK1/GUCY1A2/GUCY1A1/PLCB3/CACNB2/ADCY3/NFATC3/PRKAB1/ADCY6/ITPR3/GNAS/RYR3/CALM2/ACTB/PRKAB2/KCNJ14/OXTR/PTGS2/CACNA2D2/ELK1/NPR2/RYR2/CACNB4	1.63023333805934
NA	NA	hsa04517	IgSF CAM signaling	88/2390	299/9376	1.15459901204853	PMP22/PLCG2/TUBB2A/CTNNB1/AKT1/LRFN5/F11R/ABL1/TUBB4B/TRIO/BAIAP2/NFASC/IL1RAP/PTK2/NCK1/MAPK8/MAPK14/MAP2K1/PLXNA3/FYN/BCAR1/PIK3CA/NCK2/VAV2/SRGAP2/PRKCA/PXN/TRAF6/RAP1A/NRCAM/AFDN/PARD3/MAPK1/SLIT2/NECTIN3/PVR/JAM3/PLXNA4/ARPC1A/KIRREL1/RAPGEF2/MAPK9/PLXNA2/PDPK1/RAP1B/AKT2/NCAM2/PRKCI/DYNLL1/MAGI1/ANK3/FGFR1/ACTN1/SRGAP1/ACTN4/FOXO1/CASK/MYL12A/ERC1/MPDZ/CABLES1/MAGI2/GRIP2/CADM1/VCL/PARD6G/NTN1/NECTIN1/SORBS1/AKT3/CDC42/CLMP/ITGB3/LRRTM4/LRFN4/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/TUBB2B/PLXNA1/MYH9/PIK3R3/UNC5B/MAPK10/RAPGEF6/MYL12B	1.58906418236506
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	13/2390	34/9376	1.4999753876446	POLR2M/POLR2C/POLR3D/POLR2A/POLR1D/POLR2K/POLR2J3/POLR2B/CRCP/POLR2H/POLR2D/POLR3E/POLR3F	1.7081989511032
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	24/2390	71/9376	1.32608875007366	JUN/NFKBIA/PLCG2/F11R/NOD1/MAPK8/MAPK14/CASP3/RELA/ADAM10/JAM3/ATP6V1E2/ADAM17/MAPK9/ATP6V0A2/MAP2K4/NFKB1/ATP6V1G1/CDC42/CHUK/MAPK13/MAPK12/MAPK10/CXCL1	1.61315871872083
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	26/2390	78/9376	1.30767085076708	JUN/FOS/IRF1/NOD1/GNAI1/MAPK8/CASP1/CFL2/MAPK14/CASP3/CASP7/RELA/TRAF6/GNAI3/MAPK1/IRAK4/MAPK9/MYD88/IL6/NFKB1/TICAM1/CALM2/MAPK13/MAPK12/SERPING1/MAPK10	1.59591288409583
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	32/2390	99/9376	1.2680444613499	PLA2G4A/PLCG2/PTGER2/PPP1CB/ADCY9/CAMK2D/IL1RAP/MAPK8/PLCB1/PRKCE/MAPK14/PIK3CA/PRKCA/PRKCD/BDKRB1/IL1R1/PLCB3/MAPK9/ADCY3/ADCY6/ITPR3/GNAS/CALM2/TRPV1/TRPV3/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MAPK10/NGF	1.56816210483077
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	40/2390	128/9376	1.22594142259414	PDE4D/ADCY9/GUCY1B1/ADSL/AK4/PDE8A/PDE3A/ENTPD4/AK6/HPRT1/GUCY1A2/GUCY1A1/AK3/NME7/RRM2B/PAICS/AMPD2/IMPDH2/PPAT/GART/DCK/PDE7B/ADCY3/PAPSS1/PDE6D/GMPS/PGM2/PRPS2/PRUNE1/PDE10A/ADCY6/HDDC3/ADK/PDE1C/GMPR/AK9/NPR2/PAPSS2/ENTPD2/AK1	1.50538377596544
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	47/2390	154/9376	1.19728305167636	PPP1CB/ATP1B1/ADCY9/AKT1/GNAI1/CAMK2D/PPP2CB/PPP2R2D/PLCB1/ATF2/MAPK14/PPP2R2A/PRKCA/CACNA2D1/PPP2R3C/CREB3L2/ATP2B4/PPP2R1B/GNAI3/MAPK1/ATF4/ATP2A2/PLCB3/PPP2CA/SLC8A1/AKT2/CACNB2/ADCY3/PPP2R5A/BCL2/CREB5/PPP2R5E/RAPGEF3/PPP2R3A/ADCY6/GNAS/AKT3/PPP2R3B/CALM2/ACTC1/MAPK13/MAPK12/CACNA2D2/CREB3L4/PPP2R5B/RYR2/CACNB4	1.44380278995907
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	31/2390	97/9376	1.25374627960143	FOS/RASD1/ADCY9/GUCY1B1/PER1/GNAI1/CAMK2D/PLCB1/PRKG1/PRKCA/GNB5/GNG12/GNAI3/MAPK1/GUCY1A2/GNB2/GUCY1A1/GNB1/GNB4/GNG5/PLCB3/NOS1AP/ADCY3/GNGT1/PER2/ADCY6/ITPR3/GNAS/RYR3/CALM2/RYR2	1.46928234862813
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	17/2390	49/9376	1.36104517120656	OGT/ST3GAL3/POFUT2/GXYLT2/B4GALT1/B4GALT3/B3GLCT/GALNT2/C1GALT1C1/EOGT/GALNT15/POMT2/POGLUT1/GALNT12/ST6GAL2/B4GALT2/FUT10	1.48203646881643
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/2390	39/9376	1.40826091621071	MTHFD1L/MTHFS/MAT2A/MAT2B/DLD/GART/SHMT2/MTHFR/MTHFD1/CTH/AHCYL2/SARDH/AMT/DMGDH	1.49429632372989
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	36/2390	116/9376	1.21748665416246	PLCG2/CTNNB1/F11R/GNAI1/PTK2/MAPK14/CLDN23/BCAR1/PIK3CA/VAV2/PRKCA/PXN/RAP1A/AFDN/GNAI3/JAM3/CTNND1/RAP1B/CTNNA1/ACTN1/ACTN4/MYL12A/VCL/CLDN15/RAPGEF3/OCLN/CLDN12/CDC42/ARHGAP5/ACTB/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/MYL12B	1.37856234399151
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/2390	23/9376	1.5350918682918	HMGCS1/IDI1/FNTA/RCE1/NUS1/ZMPSTE24/ACAT1/HMGCR/MVK	1.50275125722284
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/2390	67/9376	1.2881533753825	PPP1CB/PPP3CC/RAF1/BRAF/CAMK2D/PLCB1/MAP2K1/PRKCA/PPP3R1/RAP1A/PPP3CB/PPP3CA/MAPK1/ARAF/ATF4/CREBBP/PLCB3/RAP1B/RPS6KA3/RAPGEF3/ITPR3/CALM2	1.38445835142747
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	57/2390	193/9376	1.15860992477291	STAT1/NFKBIA/STAT2/PLCG2/STAT5B/ADCY9/AKT1/GRK5/ELMO1/SOS2/RAF1/GNAI1/BRAF/PTK2/PLCB1/SHC2/STAT3/MAP2K1/SOS1/BCAR1/PIK3CA/VAV2/RELA/PXN/PRKCD/GNB5/GSK3A/RAP1A/GNG12/PARD3/GNAI3/MAPK1/JAK2/GNB2/GNB1/GNB4/GNG5/CRKL/PLCB3/RAP1B/AKT2/JAK3/ADCY3/GNGT1/NFKB1/FOXO3/CCL13/ADCY6/AKT3/CDC42/CHUK/CXCL10/PIK3R2/GRK4/PIK3CB/PIK3R3/CXCL1	1.30222797112312
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	31/2390	99/9376	1.22841807193272	TGFB2/LMNA/TGFB3/DMD/PRKAG2/ITGA1/CACNA2D1/PRKAA1/SGCE/SNTB2/ITGA3/ATP2A2/SNTB1/SLC8A1/SGCB/ITGAV/IL6/CACNB2/ITGA11/DES/ITGA9/PRKAB1/DTNA/ACTC1/ITGB3/TTN/ACTB/PRKAB2/CACNA2D2/RYR2/CACNB4	1.33633264667913
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	27/2390	85/9376	1.24613339896628	UCKL1/CMPK1/NT5C3A/CMPK2/ADSL/AK4/TYMP/DUT/ENTPD4/AK6/HPRT1/AK3/NME7/RRM2B/AMPD2/DCTD/IMPDH2/DCK/NT5C3B/GMPS/ADK/GMPR/DTYMK/AK9/ENTPD2/CTPS2/AK1	1.33327298652016
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/2390	30/9376	1.43843793584379	RELA/FPGS/GART/IL6/ABCC3/NFKB1/SHMT2/MTHFR/ABCC5/CHUK/GGH	1.40677992254725
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	79/2390	275/9376	1.12697451502472	PSMA2/EGR1/COX7A1/HSPA1B/TUBB2A/CYCS/TUBB4B/PPP3CC/PSMD9/STIP1/EIF2AK3/SDHA/SDHD/KLC1/MAPK8/ATF2/SDHB/EIF2S1/NDUFC2/MAPK14/PRNP/PSMA3/NDUFA13/FYN/CASP3/PIK3CA/NDUFS4/CSNK2A1/PSMD11/PSMC6/PPP3R1/PRKCD/NDUFV3/UQCRC2/CREB3L2/NDUFA7/NDUFA5/PPP3CB/NDUFB5/PPP3CA/APAF1/CSNK2B/HSPA1A/CSNK2A2/MAPK1/DDIT3/PSMB2/ATF4/VDAC1/HSPA8/NDUFB3/CAV2/PSMA6/MAPK9/VDAC2/MCU/ATP5F1C/NCAM2/IL6/KLC4/NOTCH1/KLC2/CREB5/NDUFA4L2/CASP9/ITPR3/RYR3/HSPA5/PIK3R2/MAPK13/PIK3CB/MAPK12/C7/TUBB2B/PIK3R3/COX6B2/CREB3L4/MAPK10/RYR2	1.24999607834634
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/2390	14/9376	1.6812910938434	ST3GAL3/B4GALT1/B4GALT3/B4GALT4/CHST2/B4GALT2	1.49204770553622
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	15/2390	44/9376	1.33739064282997	ADCY9/RAB5A/DCTN6/CREB3L2/DYNC2LI1/DYNC2H1/DYNLL1/DYNC1LI2/ADCY3/CREB5/DYNC1I1/ADCY6/GNAS/ARHGDIG/CREB3L4	1.31202558771971
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	63/2390	217/9376	1.13893912808746	KLF4/JUN/FOS/VEGFA/MYC/STAT5B/BCL6/DLL4/AHR/ADCY9/AKT1/GSTT2B/SOS2/RAF1/GNAI1/ARNT/KPNA4/ATF2/STAT3/RPS6KB1/RB1/MAP2K1/SOS1/NOTCH2/FGF2/PIK3CA/KPNA5/RELA/PRKCA/CCND3/CREB3L2/GNAI3/MAPK1/JAK2/ATF4/XIAP/PTGES3/STAT5A/PPARA/FGF10/RXRA/AKT2/ADCY3/NFKB1/VDR/CACNA1A/KPNA2/KPNA1/BCL2/CREB5/RPS6KA3/FGF22/JAG1/ADCY6/GNAS/AKT3/ESR2/PIK3R2/PIK3CB/EPHX2/PIK3R3/E2F1/CREB3L4	1.21115772788147
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	26/2390	83/9376	1.22889549831124	IRF7/NFKBIA/ADAR/TBK1/CGAS/CASP1/POLR3D/ZCCHC3/CASP3/CASP7/RELA/G3BP1/IFI16/POLR1D/POLR2K/IL6/POLR2H/RIPK1/NFKB1/POLR3E/PCBP1/CASP8/POLR3F/CHUK/CXCL10/AIM2	1.22509178348492
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	67/2390	233/9376	1.12807657083341	PDLIM3/THBS1/ATP1B1/FBLN2/SUN1/COL27A1/TMEM43/DIAPH2/AGRN/FHL2/LMNA/FMNL2/CAPZA1/SUN2/DMD/ELN/ENO2/COL5A3/DAAM2/COL6A3/ITGA1/CAPZA2/SGCE/CSRP1/SYNE3/PDLIM1/SNTB2/NEBL/COL4A1/ITGA3/SNTB1/COL6A6/AMPD2/HSPG2/PDLIM2/SDC4/SYNPO2/SGCB/ITGAV/ANK3/SDC2/ITGA11/VIM/COL11A1/DAAM1/PDLIM5/SYNE1/DES/ITGA9/VCL/MYH7B/THBS3/COL4A2/DTNA/THBS2/ACTC1/FBN2/ITGB3/TTN/ACTB/FHL1/MYH9/CAPN3/TMOD2/FLNC/ANKRD23/ACTG2	1.15790676097545
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/2390	31/9376	1.3920367121069	AFMID/MCEE/ACO1/DLD/PCCA/ACAT1/MDH1/SHMT2/PGP/GLUL/AMT	1.27875760726774
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	40/2390	134/9376	1.171048523075	PLA2G4A/ARHGEF11/PPP1CB/ADCY9/ADM/GUCY1B1/RAF1/BRAF/PLA2G5/PLCB1/PRKCE/PRKG1/MAP2K1/PRKCA/GNA12/PRKCD/KCNMA1/GNA13/ARHGEF12/PPP1R12B/PTGIR/MAPK1/GUCY1A2/GUCY1A1/ARAF/PLCB3/ARHGEF1/ADCY3/GNA11/ADORA2B/ADCY6/ITPR3/NPPC/GNAS/CALM2/PLA2G12A/MYH9/NPR2/KCNMB3/ACTG2	1.16643097431185
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	28/2390	91/9376	1.20708078532346	IFITM1/JUN/FOS/NFKBIA/PLCG2/AKT1/PPP3CC/SOS2/RAF1/MAP2K1/SOS1/BCL10/PIK3CA/VAV2/RELA/PPP3R1/PPP3CB/PPP3CA/MAPK1/MALT1/AKT2/NFKB1/NFATC3/AKT3/CHUK/PIK3R2/PIK3CB/PIK3R3	1.16102038067456
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	10/2390	28/9376	1.40107591153616	ST8SIA1/A4GALT/ST3GAL3/B4GALT1/B4GALT3/B4GALT4/FUT4/B3GALNT1/ST3GAL4/B4GALT2	1.24312998222585
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	59/2390	205/9376	1.1290621491989	COX7A1/GFPT2/PPP1CB/AKT1/TGFB2/INSR/IRS1/CAMK2D/SDHA/SDHD/MAPK8/PLCB1/SDHB/TGFBR1/PDK4/NDUFC2/TGFB3/MAPK14/NDUFA13/SMAD3/SMAD2/PIK3CA/NDUFS4/RELA/PRKCA/PRKCD/NDUFV3/UQCRC2/NDUFA7/NDUFA5/GFPT1/NDUFB5/VDAC1/ATP2A2/NDUFB3/PTEN/PLCB3/MAPK9/VDAC2/TGFBR2/PPARA/ATP5F1C/AKT2/MPC1/NFKB1/NDUFA4L2/GSR/CPT1B/AKT3/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/COX6B2/MAPK10/GYS1/AGER/RYR2	1.09279267362242
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/2390	42/9376	1.30767085076708	SLC39A14/TFRC/PRNP/PCBP2/MAP1LC3C/MAP1LC3B/ATG5/SLC11A2/VDAC2/SLC3A2/SLC7A11/PCBP1/ACSL6/CP	1.16881936232694
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	16/2390	49/9376	1.28098369054735	JUN/FOSB/GNAI1/ATF2/GPSM1/RELA/DLG4/CREB3L2/GNAI3/ATF4/NFKB1/CREB5/RGS9/GNAS/MAOB/CREB3L4	1.15339605607288
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	45/2390	154/9376	1.14633483671141	MTHFD1L/UGP2/MAT2A/CMPK1/UGDH/NADK2/CMPK2/MAT2B/ADSL/PTS/AFMID/AK4/CPOX/PANK2/VKORC1/NMNAT3/AK6/AK3/NME7/NADK/DLD/PMM2/FPGS/PANK3/HSD17B6/RDH11/LIAS/SHMT2/CAD/EARS2/RFK/MTHFD1/GPHN/LIPT1/PHOSPHO2/COX10/OXSM/COQ6/MOCS1/GGH/AK9/PPOX/CTPS2/NFS1/AK1	1.07094169375855
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	24/2390	78/9376	1.20708078532346	STAT1/JUN/FOS/NFKBIA/IFNGR2/TGFB2/IFNGR1/TGFB3/MAPK14/RELA/TRAF6/MAP3K7/MAPK1/JAK2/IRAK4/TAB2/MARCKSL1/MYD88/NFKB1/MAPK13/MAPK12/PTGS2/TAB1/ELK1	1.07414430883666
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	52/2390	181/9376	1.1270533299429	CEBPB/STAT1/KSR1/IL10RB/CYCS/AKT1/IFNGR2/PPP3CC/TGFB2/RAF1/CAMK2D/IFNGR1/MAPK8/HSPA9/TGFB3/CASP10/MAPK14/RAB5A/BCL10/NFYB/CASP3/RELA/PPP3R1/TRAF6/PPP3CB/ARHGEF12/PLK3/PPP3CA/APAF1/MAPK1/JAK2/TNFRSF1A/IRAK4/NFYA/MALT1/CREBBP/MAPK9/ATP6V0A2/MYD88/AKT2/IL6/NFKB1/VDR/BCL2/CASP9/CEBPG/CASP8/AKT3/CALM2/MAPK13/MAPK12/MAPK10	1.00953125832523
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	31/2390	104/9376	1.16935951078211	PLA2G4A/ETNK1/LPIN1/CEPT1/PLA2G5/CHPT1/SAMD8/PLD1/LPIN3/CRLS1/CHKA/PLPP5/CHKB/GNPAT/GPAT3/GPD1L/DGKD/PLPP3/PGS1/CDS2/AGPAT4/PTDSS2/SGMS1/LPGAT1/LCAT/GPD2/PISD/PNPLA7/SELENOI/PLA2G12A/LPCAT4	1.01580383169394
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	26/2390	86/9376	1.18602705069573	CTNNB1/LMNA/DMD/ITGA1/CACNA2D1/SGCE/SNTB2/ITGA3/ATP2A2/SNTB1/SLC8A1/TCF7L2/CTNNA1/SGCB/ITGAV/CACNB2/ITGA11/DES/ITGA9/LEF1/DTNA/ITGB3/ACTB/CACNA2D2/RYR2/CACNB4	1.0136493994065
NA	NA	hsa04519	Cadherin signaling	111/2390	404/9376	1.07785740917188	NFKBIA/AMOTL2/LATS2/PPP1CB/PRICKLE2/CTNNB1/TEAD1/IGF1R/PCDHGA10/SAV1/RAF1/RYK/PTK2/MAPK8/GABRE/ATN1/STK3/YAP1/NCKAP1/MAPK14/DVL1/MAP2K1/WTIP/CDH11/AXIN2/ERBIN/CSNK1A1/DAAM2/PSEN1/SHOC2/VAV2/RELA/PDGFRB/FZD2/AXIN1/FZD7/RRAS2/AJUBA/ABI2/DVL2/AFDN/TEAD3/YWHAG/MAPK1/LATS1/ADAM10/ARPC1A/MOB1A/CTNND1/CREBBP/FAT1/MAPK9/NCSTN/TCF7L2/WNT2B/PDGFRA/YWHAQ/CTNNA1/WNT6/WWTR1/KRT10/PCDH10/FGFR1/ACTN1/ACTN4/FZD1/NFKB1/MPDZ/WNT9A/VIM/RRAS/FZD6/DAAM1/ENAH/WNT10A/WASF1/WNT11/CDH8/FZD5/PCDHGA6/DES/VCL/LEF1/RERE/MYO1E/LRP5/TAOK2/PCDHGB6/PCDHGA5/PCDHB3/KRT8/CDC42/CHUK/PCDHGB5/PCDHB2/NF2/ACTB/PCDHGA8/MAPK13/YWHAZ/PCDHB14/MOB1B/MAPK12/WNT7B/MAPK10/LIMA1/LHFPL2/KRT82/KRT18/CTNND2/PCDHGB4	0.935656191772084
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	64/2390	227/9376	1.10604759183824	COX7A1/JUN/FOS/VEGFA/NFKBIA/AHR/AKT1/ABL1/PRKD3/GSTT2B/SOS2/RAF1/BRAF/PTK2/SDHA/SDHD/ARNT/MAPK8/SDHB/NDUFC2/MAPK14/NDUFA13/MAP2K1/SOS1/PIK3CA/NDUFS4/RELA/PLD1/PRKCD/NDUFV3/UQCRC2/NDUFA7/NDUFA5/NDUFB5/SOD2/ACP1/MAPK1/ARAF/VDAC1/NDUFB3/PTEN/MAPK9/VDAC2/PDPK1/ATP5F1C/AKT2/MAP2K4/NFKB1/NDUFA4L2/MAP3K5/FOXO3/HIF1A/PRKD1/AKT3/CHUK/PIK3R2/MAPK13/PIK3CB/EPHX2/MAPK12/NOX4/PIK3R3/COX6B2/MAPK10	0.94601325970634
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/2390	51/9376	1.23074903601608	PLCG2/ADCY9/ERO1A/SEC61G/ARF1/PDIA4/PRKCA/ATP6V1E2/ATP6V0A2/ADCY3/ATP6V1G1/SEC61B/KDELR2/GNAS/ACTB/SLC12A2	0.966431019895586
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	12/2390	37/9376	1.27232839534095	GLS/GFPT2/ADSL/GFPT1/ASPA/GLUD1/PPAT/CAD/RIMKLB/ABAT/GLUL/GPT2	0.970764529536279
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/2390	48/9376	1.22594142259414	AUH/HIBADH/HADHB/AACS/HMGCS1/MCEE/HIBCH/ALDH6A1/HMGCLL1/DLD/PCCA/ACAT1/ABAT/MCCC2/ACAD8	0.917893948991246
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/2390	59/9376	1.19685128714276	UCKL1/CMPK1/NT5C3A/CMPK2/TYMP/DUT/ENTPD4/NME7/RRM2B/DCTD/DCK/NT5C3B/CAD/CDADC1/DTYMK/AK9/CTPS2/DPYS	0.887148892946966
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2390	20/9376	1.37305439330544	UGP2/UGDH/UAP1/TGDS/UAP1L1/GNE/NANP	0.976815063246825
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/2390	10/9376	1.5692050209205	MPST/PAPSS1/ETHE1/PAPSS2	1.05332391246825
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/2390	78/9376	1.15678575260165	CTNNB1/ELMO1/PTK2/SHC2/BCAR1/PIK3CA/PXN/CTTN/DNM2/ARPC1A/CAV2/CRKL/CTNNA1/ARHGEF26/WASF1/VCL/DNM1/CDC42/ACTB/PIK3R2/PIK3CB/PIK3R3/ARHGAP10	0.813260021207075
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/2390	31/9376	1.26548792009718	SRP54/SEC61G/SRP9/IMMP2L/SPCS3/SRP19/SRPRB/SEC61B/HSPA5/GET4	0.865976800074242
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	33/2390	116/9376	1.11602943298225	SLC38A2/PLA2G4A/GLS/ADCY9/SLC38A1/PPP3CC/GNAI1/PLCB1/PRKCA/PLD1/PPP3R1/DLG4/GNB5/PPP3CB/GNG12/PPP3CA/GNAI3/MAPK1/GNB2/GNB1/GNB4/GNG5/PLCB3/SLC1A3/ADCY3/GNGT1/CACNA1A/DLGAP1/ADCY6/ITPR3/GNAS/HOMER1/GLUL	0.735464931032222
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	30/2390	105/9376	1.12086072922893	ADCY9/TGFB2/LMNA/TGFB3/DMD/ITGA1/CACNA2D1/SGCE/SNTB2/ITGA3/ATP2A2/SNTB1/SLC8A1/SGCB/ITGAV/CACNB2/ADCY3/ITGA11/DES/ITGA9/ADCY6/DTNA/GNAS/ACTC1/ITGB3/TTN/ACTB/CACNA2D2/RYR2/CACNB4	0.728428395917958
NA	NA	hsa04518	Integrin signaling	43/2390	154/9376	1.09538662174645	VEGFA/PDGFA/THBS1/CTNNB1/AKT1/ARHGEF6/IGF1R/PTK2/PIK3CA/NCK2/COL6A3/PDGFRB/PXN/ITGA1/CCND3/LAMA5/LAMC3/COL4A1/ITGA3/FERMT2/COL6A6/VEGFB/PDGFRA/AKT2/ITGAV/ACTN1/ACTN4/ITGA11/PDGFC/ITGA9/VCL/THBS3/COL4A2/THBS2/AKT3/CDC42/ITGB3/VEGFC/ACTB/PIK3R2/PIK3CB/TNC/PIK3R3	0.698080597558023
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	62/2390	226/9376	1.07622468248972	JUN/FOS/NFKBIA/PTGER2/PDE4D/PPP1CB/ATP1B1/ADCY9/AKT1/RAF1/GNAI1/BRAF/CAMK2D/MAPK8/PDE3A/MAP2K1/PIK3CA/VAV2/RELA/PLD1/RAP1A/CREB3L2/ATP2B4/RRAS2/AFDN/GNAI3/MAPK1/ATP2A2/CREBBP/MAPK9/PPARA/RAP1B/VIPR2/AKT2/ADCY3/GABBR1/NFKB1/AMH/GLI3/RRAS/CREB5/SSTR2/RAPGEF3/PDE10A/ACOX3/ADCY6/HCAR3/GNAS/ARAP3/AKT3/CALM2/SOX9/PIK3R2/PIK3CB/OXTR/TSHR/PIK3R3/CREB3L4/MAPK10/HTR1B/ADORA1/RYR2	0.678437108581153
Human Diseases	Substance dependence	hsa05032	Morphine addiction	26/2390	91/9376	1.12086072922893	PDE4D/ADCY9/GRK5/GNAI1/GABRE/PDE8A/PDE3A/PRKCA/GNB5/GNG12/GNAI3/GNB2/GNB1/GNB4/GNG5/PDE7B/ADCY3/GNGT1/GABBR1/CACNA1A/PDE10A/ADCY6/GNAS/GRK4/PDE1C/ADORA1	0.677618493858774
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	64/2390	235/9376	1.06839490786077	COX7A1/ARID1B/RHEB/ADCY9/SOS2/SDHA/SDHD/COX16/ATF2/SDHB/TSC2/NDUFC2/PRKG1/TSC1/MAPK14/RPS6KB1/NDUFA13/SOS1/NDUFS4/PRKAG2/PRKAA1/NDUFV3/UQCRC2/CREB3L2/NDUFA7/FRS2/NDUFA5/NDUFB5/NDUFAF4/COA1/ZNF516/COA6/NDUFB3/SMARCE1/SIRT6/KDM3A/NDUFAF7/KDM1A/ATP5F1C/ADCY3/SMARCD3/FGFR1/COA5/KDM3B/ATP5MGL/CREB5/NDUFA4L2/RPS6KA3/ACTL6A/PRKAB1/MAP3K5/CPT1B/ADCY6/GNAS/NDUFAF6/ACTB/MAPK13/PRKAB2/MAPK12/COX10/RPTOR/COX6B2/CREB3L4/ACSL6	0.621056545796464
Organismal Systems	Endocrine system	hsa04924	Renin secretion	20/2390	69/9376	1.13710508762355	PTGER2/GUCY1B1/PPP3CC/GNAI1/PLCB1/PDE3A/PPP3R1/KCNMA1/PPP3CB/PPP3CA/GNAI3/GUCY1A2/GUCY1A1/PLCB3/ADCY6/ITPR3/GNAS/CALM2/PDE1C/ADORA1	0.668564876790348
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	20/2390	69/9376	1.13710508762355	JUN/FOS/FOSB/SIRT1/PPP1CB/PPP3CC/CAMK2D/ATF2/PRKCA/PPP3R1/ARC/CREB3L2/PPP3CB/PPP3CA/ATF4/CREB5/GNAS/CALM2/MAOB/CREB3L4	0.668564876790348
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	46/2390	168/9376	1.07415819884439	STAT1/EIF2AK2/STAT2/PLA2G4A/IRF9/FAS/STAT5B/IFNGR2/CHMP5/CAMK2D/IFNGR1/MAPK8/CASP1/STAT3/TRPM7/BIRC2/DNM1L/STAT6/GLUD1/CAPN2/JAK2/TNFRSF1A/PPID/VDAC1/XIAP/STAT5A/MAPK9/VDAC2/CHMP7/SHARPIN/JAK3/RIPK1/CYLD/SQSTM1/TRAF5/BCL2/TICAM1/USP21/IFNAR1/SPATA2L/CASP8/TNFRSF10B/GLUL/PGAM5/MAPK10/TNFAIP3	0.567285204386217
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/2390	44/9376	1.15907189045264	POLD4/POLG2/POLE/PARP4/NEIL2/MUTYH/POLD3/OGG1/POLG/PARG/RFC4/POLD1/TDP1	0.618589741583294
NA	NA	hsa04081	Hormone signaling	59/2390	219/9376	1.05688466020901	IRS2/STAT5B/SMAD4/ADCY9/EPOR/THRB/IGF1R/GNAI1/INSR/IRS1/ADIPOR1/PLCB1/STAT3/PRKG1/PIK3CA/STK11/BMPR1A/GNA12/GNB5/GNA13/GNG12/LEPR/GNAI3/JAK2/GNB2/GNB1/GNB4/GNG5/PLCB3/STAT5A/VIPR2/ITGAV/UCN/ADCY3/GNGT1/PTH1R/AMH/ACVR1/ADIPOR2/GNA11/ADRA2C/SSTR2/RAPGEF3/ADCY6/NPPC/GNAS/SMAD1/ESR2/ITGB3/PIK3R2/HCRTR2/PIK3CB/ADRA2A/OXTR/NPR3/TSHR/PIK3R3/MC1R/NPR2	0.498208251955257
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	32/2390	116/9376	1.08221035925552	ALDOA/DLST/PFKP/SDHA/SDHD/SDHB/SUCLA2/ME3/ENO2/SUCLG2/HK2/MCEE/IDH3A/HIBCH/GLUD1/ALDH6A1/ACO1/DLD/PCCA/RPIA/ACAT1/MDH1/SHMT2/PRPS2/DLAT/FH/ACOX3/PSPH/RPE/PGP/AMT/GPT2	0.52109912671246
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	82/2390	308/9376	1.0444384067815	PSMA2/COX7A1/TUBB2A/CYCS/TUBB4B/PSMD9/SDHA/SDHD/KLC1/BBC3/POLR2C/MAPK8/PLCB1/SDHB/ULK1/NDUFC2/PSMA3/POLR2A/NDUFA13/TBPL1/ERN1/ACTR10/CASP3/NRF1/NDUFS4/PSMD11/PSMC6/DCTN6/DLG4/NDUFV3/UQCRC2/CREB3L2/NDUFA7/NDUFA5/AP2A1/NDUFB5/SOD2/RCOR1/APAF1/TAF4/PSMB2/POLR2K/POLR2J3/VDAC1/SIN3A/NDUFB3/PSMA6/CREBBP/PLCB3/SLC1A3/MAPK9/VDAC2/POLR2B/ATP5F1C/ATG101/POLR2H/KLC4/IFT57/ATG13/POLR2D/GPX8/ATG2B/KLC2/RB1CC1/CREB5/ULK2/NDUFA4L2/WIPI1/TGM2/CASP9/MAP3K5/AMBRA1/CASP8/PIK3R4/MAP3K10/TUBB2B/DNAL4/COX6B2/CREB3L4/MAPK10/DNAL1/DNAH9	0.463818834919108
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/2390	19/9376	1.23884606914776	DLST/DLD/LIAS/DLAT/LIPT1/AMT	0.609532521053229
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	23/2390	83/9376	1.08709986389071	FAR1/ECI2/SOD2/ABCD4/ABCD3/HMGCLL1/GNPAT/HSD17B4/PEX13/SLC25A17/PXMP2/PEX2/PEX14/NUDT19/AGPS/ACOX3/PEX3/PEX5/MPV17L/EPHX2/HACL1/MVK/ACSL6	0.46617486312497
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/2390	23/9376	1.19396034200473	ST3GAL3/B4GALT1/B4GALT3/FUT4/POMT2/B3GALNT2/B4GALT2	0.544717954188817
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2390	27/9376	1.16237408957074	ACOT2/ELOVL2/ELOVL5/HSD17B4/HACD1/ACOX3/HACD2/ELOVL3	0.494181324693561
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/2390	20/9376	1.17690376569038	LSS/SQLE/MSMO1/HSD17B7/CYP51A1/CYP2R1	0.463209296479091
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	24/2390	89/9376	1.05789102533966	SLC38A2/GLS/ADCY9/SLC38A1/GABARAPL1/GNAI1/GABRE/PRKCA/GNB5/GNG12/GNAI3/GNB2/GNB1/GNB4/GNG5/GABARAPL2/ADCY3/GNGT1/GABBR1/CACNA1A/ABAT/ADCY6/GPHN/GLUL	0.320951064340831
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/2390	24/9376	1.1442119944212	XYLT1/HS3ST3B1/XYLT2/EXT1/HS6ST1/NDST1/B4GALT7	0.413737659081697
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	13/2390	47/9376	1.08508857829609	LDHA/ME3/ACYP1/ACYP2/DLD/ACAT1/GLO1/MDH1/DLAT/ACACA/FH/ACACB/ADH1B	0.342036889081717
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	70/2390	268/9376	1.02466745769063	PSMA2/COX7A1/DUSP1/XBP1/TUBB2A/CYCS/SLC39A14/TUBB4B/PSMD9/SLC39A13/GNAI1/CAMK2D/EIF2AK3/SDHA/SDHD/KLC1/MAPK8/SDHB/EIF2S1/UBE2L6/NDUFC2/PSMA3/NDUFA13/ERN1/CASP3/NDUFS4/PSMD11/PSMC6/NDUFV3/UQCRC2/NDUFA7/TXN/NDUFA5/NDUFB5/UBE2J2/APAF1/GNAI3/DDIT3/PSMB2/TRAP1/ATF4/VDAC1/NDUFB3/PSMA6/SLC11A2/UBE2G1/MAPK9/VDAC2/MFN1/MCU/ATP5F1C/UBE2J1/KLC4/MFN2/SLC39A6/KLC2/NDUFA4L2/CASP9/MAPT/MAP3K5/ITPR3/GNAS/RYR3/CALM2/SLC39A10/HSPA5/TUBB2B/MAOB/COX6B2/MAPK10	0.239635180218843
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/2390	55/9376	1.06991251426398	CERS2/UGCG/SPTLC1/DEGS1/SAMD8/SMPD4/CERS6/CERS5/KDSR/SGPL1/SGPP1/PLPP3/ACER3/SGMS1/NEU3	0.304141238231243
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/2390	36/9376	1.08972570897257	POLD4/POLE/PRIM2/RPA4/RNASEH2B/POLD3/RFC4/RNASEH2A/POLD1/PRIM1	0.315475043502625
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/2390	17/9376	1.15382722126508	PAPSS1/SEPHS1/CTH/SEPSECS/PAPSS2	0.371289980863088
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2390	17/9376	1.15382722126508	CA5B/GLUD1/CA8/CA5A/GLUL	0.371289980863088
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/2390	75/9376	1.04613668061367	ATP1B1/ADCY9/PLCB1/ATF2/PDIA4/PRKCA/CREB3L2/ATF4/PLCB3/ADCY3/GPX8/CREB5/GSR/ADCY6/ITPR3/GNAS/HSPA5/TSHR/CREB3L4/TTF2	0.234629412276517
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	27/2390	103/9376	1.02836251371004	TGFB2/PTK2/PLCB1/TGFB3/RAB5A/CASP3/PIK3CA/RELA/PRKCA/LAMA5/LAMC3/COL4A1/IL1R1/PLCB3/IL6/SERPINB9/ACTN1/ACTN4/NFKB1/GNA11/VCL/COL4A2/GNAS/PIK3R2/PIK3CB/PIK3R3/CXCL1	0.169286957336895
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	14/2390	53/9376	1.03626746664561	ATP1B1/ADCY9/PLCB1/PRKCA/AP2A1/ATP2B4/DNM2/PLCB3/SLC8A1/PTH1R/VDR/DNM1/ADCY6/GNAS	0.154862979631285
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/2390	57/9376	1.0323717242898	ELOVL2/HADHB/ACADVL/ELOVL5/HSD17B4/HACD1/ACAT1/CPT1B/ACACA/ACOX3/HACD2/ELOVL3/CBR4/OXSM/ACSL6	0.143380107887947
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	17/2390	65/9376	1.02601866752494	NR4A1/ADCY9/PLCB1/ATF2/PDE8A/CREB3L2/PBX1/ATF4/PLCB3/ADCY3/GNA11/CREB5/LDLR/ADCY6/ITPR3/GNAS/CREB3L4	0.123115820737434
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	17/2390	65/9376	1.02601866752494	AKT1/RAF1/PLCB1/MAP2K1/PIK3CA/PRKCA/MAPK1/PLCB3/AKT2/GABBR1/GNA11/ITPR3/AKT3/ESR2/PIK3R2/PIK3CB/PIK3R3	0.123115820737434
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/2390	18/9376	1.08972570897257	ACACA/ACACB/CBR4/OXSM/ACSL6	0.222859898695462
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/2390	18/9376	1.08972570897257	LMBRD1/THAP11/ABCD4/MTRR/ZNF143	0.222859898695462
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/2390	30/9376	1.04613668061367	PIGA/PIGF/PIGL/PIGC/PIGN/PIGO/PIGG/PGAP1	0.148034991213459
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	10/2390	38/9376	1.0323717242898	SIRT1/NADK2/NMNAT3/NADK/SIRT6/NAMPT/NNMT/SIRT7/NNT/SIRT5	0.116950206876451
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/2390	38/9376	1.0323717242898	ATP1B1/INSR/IRS1/PIK3CA/PRKCA/MAPK1/PDPK1/PIK3R2/PIK3CB/PIK3R3	0.116950206876451
Genetic Information Processing	Transcription	hsa03040	Spliceosome	62/2390	243/9376	1.00093324379703	TRA2A/EIF4A3/SRSF6/HSPA1B/DDX5/SRSF7/PHF5A/DDX39B/SRSF3/SRSF1/THOC3/SRSF5/SRSF9/THOC1/SF1/U2AF2/CHERP/SRSF2/SF3B1/LSM8/SNRPA1/ACIN1/PRPF18/SF3B3/HSPA1A/SF3B6/DHX15/THOC7/MAGOH/SMNDC1/SRSF10/HSPA8/ALYREF/MAGOHB/PLRG1/SNRNP40/PRPF8/RBM17/SF3A3/PRPF3/FUS/BUD13/RBMXL1/THOC6/LSM6/HNRNPA3/PRPF4/BCAS2/AQR/HNRNPU/TCERG1/RP9/DDX42/DHX38/NCBP2/HNRNPA1/HNRNPK/PRPF40B/PCBP1/TRA2B/YJU2/HNRNPC	0.00862108283485425
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2390	23/9376	1.0233945788612	GLS/GLUD1/CAD/GLUL/ACY1/GPT2	0.0657013026718082
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2390	51/9376	0.999983591763065	PLA2G4A/CEPT1/PLA2G5/CHPT1/PLD1/PAFAH1B1/GDPD3/PAFAH1B2/PLPP3/AGPS/SELENOI/PLA2G12A/LPCAT4	-6.87215402047348e-05
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/2390	15/9376	1.04613668061367	AK4/ACP1/NFS1/AK1	0.104592646038703
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	13/2390	52/9376	0.980753138075314	PLA2G4A/ADCY9/IGF1R/INSR/ACOT2/HSD17B2/HSD17B7/BMP6/ADCY3/LDLR/ADCY6/GNAS/PTGS2	-0.0814011926773669
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/2390	52/9376	0.980753138075314	MYLIP/ABCA1/LDLRAP1/VAPA/ANGPTL4/VDAC1/VDAC2/VAPB/LDLR/STARD3/LCAT/OSBPL5/LRP1	-0.0814011926773669
NA	NA	hsa03272	Virion - Hepatitis viruses	12/2390	48/9376	0.980753138075314	PDCD6IP/CLDN23/IST1/TSG101/HSPG2/CHMP7/LDLR/CD9/CLDN15/OCLN/CLDN12/DPP4	-0.07819096602518
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2390	28/9376	0.980753138075314	ACOT2/ELOVL2/HADHB/ELOVL5/HACD1/HACD2/ELOVL3	-0.0596554179249962
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/2390	28/9376	0.980753138075314	PTS/FPGS/PCBD1/MOCOS/GPHN/MOCS1/GGH	-0.0596554179249962
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	24/2390	98/9376	0.960737767910511	NR4A1/ATP1B1/ADCY9/PRKD3/CAMK2D/PLCB1/ATF2/PRKCE/PRKCA/CREB3L2/ATP2B4/ATF4/PLCB3/ADCY3/GNA11/ATF1/CREB5/LDLR/PRKD1/ADCY6/ITPR3/GNAS/CALM2/CREB3L4	-0.228523642475798
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	21/2390	86/9376	0.957944925561934	ATP1B1/ADCY9/CAMK2D/PLCB1/ATF2/PRKCA/KCNMA1/CREB3L2/ATF4/PLCB3/ADCY3/GNA11/CREB5/RIMS2/ADCY6/ITPR3/GNAS/FFAR1/CREB3L4/RYR2/KCNMB3	-0.229155387814358
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	16/2390	66/9376	0.951033346012426	STAT1/JUN/IL18R1/IFNGR2/TGFB2/IL4R/IFNGR1/STAT3/TGFB3/SMAD3/SMAD2/RELA/STAT6/IL6/NFKB1/RORA	-0.233489768148166
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/2390	21/9376	0.934050607690775	CSAD/PANK2/AASDHPPT/PANK3/DPYS	-0.176957448445712
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/2390	75/9376	0.941523012552301	ALDOA/MAT2A/PFKP/MAT2B/ENO2/IDH3A/ALDH18A1/ACO1/RPIA/SHMT2/PRPS2/PYCR2/PSPH/CTH/RPE/GLUL/ACY1/GPT2	-0.297386396551687
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/2390	43/9376	0.912328500535176	HADHB/ACADVL/ECI2/ACAT1/GCDH/CPT1B/ACOX3/ADH1B/ACSL6/CYP2U1	-0.337017402750417
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2390	31/9376	0.885841544068025	ALDOA/PFKP/DERA/RPIA/PGM2/PRPS2/RPE	-0.37236562150625
NA	NA	hsa04981	Folate transport and metabolism	7/2390	31/9376	0.885841544068025	MTHFS/FPGS/ABCC3/SHMT2/MTHFR/ABCC5/MTHFD1	-0.37236562150625
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/2390	48/9376	0.899023709902371	ATP1B1/AKT1/PLCB1/PIK3CA/HK2/PLCB3/AKT2/AKT3/PIK3R2/PIK3CB/PIK3R3	-0.410219271030655
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/2390	27/9376	0.871780567178057	AACS/HMGCS1/HMGCLL1/ACAT1/ABAT/L2HGDH	-0.390232513887624
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	27/2390	115/9376	0.921055120975077	DUSP1/PLA2G4A/RAF1/GNAI1/BRAF/PLCB1/MAP2K1/CASP3/PRKCA/GNB5/GNG12/GNAI3/MAPK1/GNB2/ARAF/GNB1/GNB4/GNG5/PLCB3/GNGT1/CACNA1A/RAPGEF3/ITPR3/GNAS/MAOB/PTGS2/HTR1B	-0.498212064080404
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/2390	23/9376	0.852828815717664	PREP/MME/LNPEP/MAS1/THOP1	-0.413315348845201
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2390	23/9376	0.852828815717664	GLS/ATP1B1/GLUD1/MDH1/SLC9A3	-0.413315348845201
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/2390	70/9376	0.896688583383144	CYCS/ABL1/DMD/FYN/CASP3/SGCE/HLA-F/CD55/SNTB2/SNTB1/SGCB/EIF4G2/CASP9/DTNA/CASP8/ACTB	-0.507441650072977
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	35/2390	149/9376	0.921513015641234	ADCY9/GNAI1/MAPK8/PLCB1/GABRE/NDUFC2/MAPK14/NDUFA13/NDUFS4/PRKCA/NDUFV3/GNB5/NDUFA7/NDUFA5/NDUFB5/GNG12/GNAI3/MAPK1/GNB2/GNB1/NDUFB3/GNB4/GNG5/PLCB3/MAPK9/ADCY3/GNGT1/CACNA1A/NDUFA4L2/ADCY6/ITPR3/MAPK13/MAPK12/PTGS2/MAPK10	-0.564846984784282
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/2390	32/9376	0.8581589958159	UGP2/PFKP/HK2/B4GALT1/GANC/PGM2/B4GALT2	-0.470089628519763
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/2390	19/9376	0.825897379431843	IDS/ARSB/GALNS/IDUA	-0.444307957905848
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/2390	33/9376	0.832154177760872	DLST/IDH3A/ACO1/DLD/DLAT/ACY1/GPT2	-0.564929988779794
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	60/2390	254/9376	0.926695878496359	P2RX2/VEGFA/PLCG2/PDGFA/ADCY9/PPP3CC/CAMK2D/PLCB1/CYSLTR2/FGF2/GDNF/PHKG1/PDGFRB/PRKCA/PPP3R1/PPP3CB/ATP2B4/PPP3CA/FGFR2/TPCN1/PTGFR/VDAC1/ATP2A2/BDKRB1/VEGFB/PLCB3/FGFR3/VDAC2/SLC8A1/PDGFRA/FGF10/MCU/PHKB/ADCY3/FGFR4/FGFR1/NFATC3/CACNA1A/PDGFC/GNA11/EDNRB/ADORA2B/RET/ITPKA/FGF22/TPCN2/ITPR3/GNAS/ASPH/STIM1/RYR3/CALM2/VEGFC/PHKA2/STIM2/PDE1C/OXTR/NGF/P2RX6/RYR2	-0.692740399605493
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/2390	89/9376	0.88157585444972	THBS1/AGRN/CD47/COL6A3/ITGA1/LAMA5/LAMC3/COL4A1/ITGA3/COL6A6/HSPG2/SDC4/ITGAV/ITGA11/ITGA9/THBS3/COL4A2/THBS2/ITGB3/TNC	-0.656550049597656
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	56/2390	238/9376	0.92306177701206	MX2/MX1/OAS1/OAS2/ISG15/OAS3/RPL17/STAT1/EIF2AK2/JUN/FOS/RPL36A/RPS10/NFKBIA/STAT2/IFIH1/PLCG2/IRF9/ADAR/TBK1/RPL22L1/CGAS/MAPK8/CASP1/STAT3/CFB/MAPK14/PIK3CA/RELA/PRKCA/TRAF6/MAP3K7/RPS21/MAPK1/TNFRSF1A/IRAK4/TAB2/ADAM17/RSL24D1/MAPK9/MYD88/IL6/NFKB1/RPS27L/IFNAR1/CHUK/CXCL10/PIK3R2/MAPK13/PIK3CB/MAPK12/TRAF3/C7/MAS1/PIK3R3/MAPK10	-0.703194315061398
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	30/2390	133/9376	0.88489004939126	PLCG2/FAS/IFNGR2/PPP3CC/SOS2/RAF1/BRAF/IFNGR1/SHC2/SH3BP2/MAP2K1/SOS1/FYN/CASP3/PIK3CA/VAV2/PRKCA/PPP3R1/PPP3CB/PPP3CA/MAPK1/ARAF/ULBP1/MICA/IFNAR1/PIK3R2/TNFRSF10B/PIK3CB/KLRD1/PIK3R3	-0.781992359099652
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/2390	61/9376	0.836051855408464	ATP1B1/TRPM7/CYBRD1/ATP2B4/SLC11A2/MT2A/SLC8A1/SLC30A1/MT1E/VDR/ATP7B/CLCN2/SLC9A3	-0.751363842703784
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2390	16/9376	0.735564853556485	ST8SIA1/A4GALT/B3GALNT1	-0.619172333220733
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	58/2390	250/9376	0.910138912133891	NCOA7/IDS/ABCA5/AP1G1/AP3S1/ARSB/VPS13C/SPG11/LAMTOR3/PIKFYVE/VPS29/ENTPD4/AP2A1/GALNS/OSBP/ARL8A/SLC36A4/KXD1/DMXL1/TPCN1/BLOC1S4/AP5B1/CD164/ARL8B/BLOC1S2/VPS26A/SLC38A9/ATP6V1E2/SLC11A2/RRAGB/DEPTOR/OSBPL2/ATP6V0A2/BLOC1S6/SCARB2/AP4M1/LAPTM4A/AP5M1/ATP6V1G1/PLEKHM1/OSTM1/VPS13A/VAMP7/CTBS/OSBPL5/TPCN2/TTI1/AP1G2/AP4S1/MFSD8/ZFYVE26/SLC2A6/VPS33A/RPTOR/AP4B1/IDUA/AP4E1/CLN3	-0.842309583631632
Cellular Processes	Cell motility	hsa04814	Motor proteins	44/2390	194/9376	0.889755424233274	TUBB2A/TUBB4B/TUBE1/KLC1/MYO9A/CAPZA1/DYNLT3/ACTR10/CAPZA2/DCTN6/STARD9/TUBD1/KIFC3/DYNC2LI1/DYNC2H1/DYNLL1/DYNC1LI2/DYNLT1/KLC4/MYO6/MYL12A/KIF27/KLC2/KIF13A/KIF7/HOOK3/DYNC1I1/MYH7B/KIF14/MYO1E/ACTC1/ACTB/KIFC2/TUBB2B/DNAL4/MYO15B/MYH9/DNAL1/MYO15A/KIF9/DNAH9/MYL12B/KIF2C/ACTG2	-0.907527406830909
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/2390	31/9376	0.759292752058307	CSAD/HIBCH/ALDH6A1/ACOX3/ABAT/DPYS	-0.785146428699747
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/2390	54/9376	0.799132186579885	AMD1/MAT2A/LDHA/MAT2B/MRI1/MTAP/MPST/MDH1/APIP/CTH/AHCYL2	-0.865810763732786
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2390	17/9376	0.692296332759045	CSAD/GGT7/FMO4	-0.742698774520051
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/2390	12/9376	0.653835425383542	VKORC1/COQ6	-0.701799153483177
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/2390	12/9376	0.653835425383542	CD46/NCAM2	-0.701799153483177
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/2390	41/9376	0.76546586386366	DLD/SHMT2/PSPH/CTH/MAOB/SARDH/AMT/DMGDH	-0.880260325126892
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/2390	46/9376	0.767545934145898	PSMA2/PSMD9/PSMA3/PSMD11/PSMC6/PSMB2/PSMA6/PSMB10/PSME4	-0.924369354255687
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/2390	37/9376	0.742191563948886	FAS/PLCB1/PRKCA/PLCB3/MYD88/IL6/THOP1	-0.919005470657258
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/2390	18/9376	0.653835425383542	MAN2C1/ENGASE/NEU3	-0.8598004174541
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/2390	13/9376	0.603540392661732	RAD50/MRE11	-0.836629952735307
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/2390	93/9376	0.801475682728214	ATP1B1/ADCY9/GUCY1B1/PLCB1/PRKG1/PRKCA/KCNMA1/ATP2B4/GUCY1A2/GUCY1A1/PLCB3/ADCY3/PRH1/ADCY6/ITPR3/GNAS/RYR3/CALM2/SLC12A2	-1.12533365720348
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/2390	29/9376	0.676381474534699	GNB1/GNGT1/RGS9/CALM2/GUCA1B	-1.02086085332941
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	21/2390	102/9376	0.807679054885552	ATP1B1/ADCY9/PLA2G5/PLCB1/PRKCA/RAB8A/KCNMA1/RAP1A/ATP2B4/ATP2A2/PLCB3/RAP1B/ADCY3/TPCN2/ADCY6/ITPR3/GNAS/SLC12A2/PLA2G12A/SCT/RYR2	-1.14225593347544
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/2390	76/9376	0.774278793217353	ATP1B1/ADCY9/GNAI1/CAMK2D/PLCB1/PRKCA/GNAI3/PLCB3/ADCY3/SSTR2/ADCY6/ITPR3/GNAS/CALM2/ACTB	-1.15560119793695
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/2390	35/9376	0.672516437537358	ALDOA/PFKP/HK2/PMM2/PFKFB3/FPGT	-1.13526471621722
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/2390	50/9376	0.706142259414226	OAT/AMD1/P4HA1/ODC1/CKB/L3HYPDH/ALDH18A1/PYCR2/MAOB	-1.21855385991131
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/2390	50/9376	0.706142259414226	THBS1/TGFB2/TGFB3/MYD88/IL6/SDC2/THBS3/THBS2/LRP1	-1.21855385991131
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/2390	15/9376	0.523068340306834	ST8SIA1/SLC33A1	-1.081212250284
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2390	36/9376	0.653835425383542	UGP2/GBE1/HK2/GANC/PGM2/GYS1	-1.21711252534743
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/2390	26/9376	0.603540392661732	PLA2G4A/PLA2G5/ACOX3/PLA2G12A	-1.18399566711985
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/2390	26/9376	0.603540392661732	SLC19A2/LMBRD1/ABCD4/SLC19A3	-1.18399566711985
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	71/2390	323/9376	0.862334028524425	SOCS1/IRS2/VEGFA/DDIT4/PIM1/PLCG2/PDGFA/MYC/SIRT1/GLS/THBS1/BMI1/MDM4/ABL1/HOXD10/CDKN1A/SOS2/TGFB2/RAF1/IRS1/TIMP3/MCL1/STAT3/PRKCE/MAP2K1/MDM2/SOS1/NOTCH2/ATM/CASP3/PIK3CA/PDGFRB/PRKCA/ZFPM2/MAPK7/UBE2I/MAPK1/CCNG1/HDAC5/PTEN/FSCN1/CRKL/CREBBP/FGFR3/PDGFRA/BCL2L11/PLAU/NFKB1/BCL2L2/VIM/NOTCH1/IGF2BP1/BCL2/SPRY2/HDAC4/CDKN2A/RECK/BMF/EFNA5/HNRNPK/ITGB3/SLC7A1/PIK3R2/PIK3CB/TNC/PTGS2/RPTOR/PIK3R3/E2F1/SOX4/MMP16	-1.47265800627273
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	20/2390	103/9376	0.761750010155584	SLC38A2/COL16A1/ATP1B1/COL27A1/COL8A2/ELN/COL5A3/COL6A3/SLC36A4/COL4A1/COL6A6/SLC8A1/SLC3A2/MME/COL11A1/COL4A2/DPP4/COL8A1/SLC9A3/COL19A1	-1.42203953706802
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/2390	16/9376	0.490376569037657	MIF/MAOB	-1.19327832573236
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/2390	22/9376	0.534956257131989	ASPA/CARNMT1/MAOB	-1.27725249877719
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/2390	63/9376	0.684970445639902	PLA2G4A/PLA2G5/PTGIS/PTGR1/PTGES3/LTA4H/CYP4F8/PLA2G12A/EPHX2/PTGS2/CYP2U1	-1.46739511891278
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/2390	17/9376	0.46153088850603	TFRC/MYH9	-1.29969315221162
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/2390	76/9376	0.671041620788373	ME3/HMGCS1/ANGPTL4/PDPK1/PPARA/RXRA/PPARD/CPT1B/ACOX3/SORBS1/OLR1/PLIN2/ACSL6	-1.68413372632022
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/2390	42/9376	0.560430364614465	DLST/AFMID/DLD/ACAT1/GCDH/MAOB	-1.6698933280441
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/2390	37/9376	0.530136831392062	COMT/MIF/MAOB/ADH1B/LRTOMT	-1.67491347073467
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/2390	28/9376	0.420322773460849	ATP6V1E2/ATP6V0A2/ATP6V1G1	-1.79670261812613
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/2390	82/9376	0.621941014389223	UCKL1/CMPK1/GSTT2B/TYMP/DUT/HPRT1/NME7/RRM2B/IMPDH2/GMPS/CDADC1/NAT1/DPYS	-2.01110828374348
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/2390	82/9376	0.621941014389223	HSPA1B/HSPA2/TAP2/TAP1/NFYB/HLA-F/HSPA1A/NFYA/HSPA8/CALR/HSPA5/KLRD1/B2M	-2.01110828374348
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/2390	67/9376	0.585524261537501	ALDOA/PFKP/LDHA/MINPP1/ENO2/HK2/DLD/PGM2/DLAT/ADH1B	-1.99138530588707
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/2390	46/9376	0.511697289430599	CPOX/EARS2/COX10/FXN/PPOX/CP	-1.94176883760613
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/2390	88/9376	0.624115633320654	SERPINE1/CFB/F3/TFPI/CD55/BDKRB1/PROS1/CD46/F5/PLAU/SERPINE2/PLAT/SERPING1/C7	-2.07207177124834
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/2390	155/9376	0.70867323525442	SEC22B/THBS1/TUBB2A/TAP2/TUBB4B/TAP1/SEC61G/TFRC/RAB5A/STX7/PIKFYVE/STX12/HLA-F/DYNC2H1/ATP6V1E2/ATP6V0A2/ITGAV/DYNC1LI2/ATP6V1G1/SEC61B/CALR/DYNC1I1/THBS3/THBS2/ITGB3/ACTB/TUBB2B/OLR1	-2.1390824373645
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	34/2390	183/9376	0.728865720099687	NXT1/NXF1/REXO2/SBDS/XRN1/XPO1/CSNK2A1/EFL1/FCF1/AK6/GNL3/NMD3/CSNK2B/NOP56/CSNK2A2/UTP6/BMS1/UTP18/WDR36/RPP30/UTP4/RCL1/NOP10/HEATR1/NOB1/GTPBP4/GNL2/RIOK2/GNL3L/NVL/MDN1/NXT2/RPP40/PWP2	-2.16646482597926
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/2390	36/9376	0.435890283589028	UGP2/UGDH/FGGY/RPE	-1.98340630977246
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/2390	36/9376	0.435890283589028	GALNT2/C1GALT1C1/GALNT15/GALNT12	-1.98340630977246
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2390	30/9376	0.392301255230126	PLA2G4A/PLA2G5/PLA2G12A	-1.94987322767619
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/2390	138/9376	0.682263052574131	COX7A1/CYCS/SDHA/SDHD/SDHB/NDUFC2/NDUFA13/NDUFS4/NDUFV3/UQCRC2/NDUFA7/NDUFA5/NDUFB5/PPA1/NDUFB3/ATP6V1E2/ATP6V0A2/ATP5F1C/ATP6V1G1/ATP5MGL/NDUFA4L2/PPA2/COX10/COX6B2	-2.19932079774685
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/2390	43/9376	0.456164250267588	PLA2G5/ABCA1/PLPP3/ACAT1/PLA2G12A	-2.0905552319335
Human Diseases	Substance dependence	hsa05034	Alcoholism	35/2390	191/9376	0.718876645709654	FOSB/PPP1CB/SOS2/RAF1/GNAI1/BRAF/ATF2/SHC2/MAP2K1/SOS1/HAT1/GNB5/CREB3L2/GNG12/GNAI3/MAPK1/GNB2/ARAF/ATF4/GNB1/HDAC5/GNB4/GNG5/GNGT1/HDAC6/CREB5/HDAC4/ADORA2B/HDAC3/GNAS/CALM2/CAMKK1/HDAC8/MAOB/CREB3L4	-2.29585432159964
Organismal Systems	Sensory system	hsa04742	Taste transduction	13/2390	86/9376	0.593013525347864	P2RX2/PLCB1/PLCB3/GABBR1/CACNA1A/ADCY6/ITPR3/TAS2R30/PDE1C/TAS2R46/HTR1B/TAS2R19/ENTPD2	-2.21764304736773
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/2390	17/9376	0.230765444253015	HSD17B4	-1.85668752990319
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/2390	87/9376	0.586197277930073	COX7A1/ATP1B1/CACNA2D1/UQCRC2/ATP2A2/SLC8A1/CACNB2/ASPH/ACTC1/CACNA2D2/COX6B2/RYR2/CACNB4	-2.26797773175225
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2390	26/9376	0.301770196330866	HES1/MAFA	-2.08520880033269
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/2390	79/9376	0.546242254117896	STX2/STXBP1/AP2A1/DNM2/ATP6V1E2/SLC1A3/ATP6V0A2/CACNA1A/ATP6V1G1/DNM1/UNC13B	-2.36884410193493
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/2390	100/9376	0.588451882845188	IL11/EPOR/IL4R/TFRC/CSF1/ITGA1/CD55/ITGA3/IL1R1/FLT3LG/IL6/MME/KITLG/CD9/ITGB3	-2.41997314844103
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/2390	65/9376	0.482832314129385	LPIN1/LPIN3/PLPP5/GPAT3/ABHD16A/DGKD/PLPP3/AGPAT4	-2.44714776587998
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	34/2390	195/9376	0.684012445016629	PLCG2/AKT1/RAF1/PLCB1/CASP1/MAPK14/MAP2K1/HAT1/CASP4/PIK3CA/RELA/PRKCA/MAP3K7/MAPK1/VDAC1/HDAC5/PLCB3/VDAC2/CLCN3/AKT2/NFKB1/HDAC6/HDAC4/HDAC3/AKT3/ITGB3/ACTB/HDAC8/PIK3R2/MAPK13/PIK3CB/MAPK12/PIK3R3/AGER	-2.60803003444743
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/2390	95/9376	0.536833296630698	JUN/FOS/VEGFA/IL11/TGFB2/TGFB3/CSF1/ATP6V1E2/ATP6V0A2/IL15/IL6/ATP6V1G1/CXCL1	-2.65382355883246
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/2390	38/9376	0.309711517286941	TAP2/TAP1/JAK3	-2.49382393520355
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/2390	45/9376	0.348712226871223	FAS/HLA-F/IL6/KLRD1	-2.5614470657116
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/2390	59/9376	0.398950429047585	GSTT2B/ODC1/RRM2B/GGT7/GPX8/GSR	-2.70874765014868
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/2390	66/9376	0.416077088880436	COMT/HSD17B2/HSD17B7/HSD17B6/HSD11B1/CYP3A5/LRTOMT	-2.78434432477877
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/2390	90/9376	0.479479311947931	ATP1B1/ADCY9/RXRA/ADCY3/ABCC3/LDLR/HMGCR/ADCY6/GNAS/SLC9A3/SCT	-2.902118944949
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	52/2390	298/9376	0.684552525904917	IL11/FAS/IL10RB/IL18R1/IFNGR2/EPOR/IL15RA/TGFB2/IL4R/TNFRSF12A/IL1RAP/IFNGR1/TGFBR1/ACVR1B/TNFRSF10D/TGFB3/BMP2/GDF5/RELT/CLCF1/CSF1/OSMR/BMPR1A/GDF6/LEPR/TNFRSF1A/LIF/IL1R1/BMP6/TGFBR2/IL15/IL16/ACVR2B/IL6/AMH/ACVR1/BMP7/IFNAR1/IL17RC/CCL13/ACKR3/TNFSF9/IL1RL1/INHBB/TNFSF15/CXCL10/TNFRSF10B/TNFRSF19/CTF1/BMP4/NGF/CXCL1	-3.23675922954894
NA	NA	hsa04082	Neuroactive ligand signaling	31/2390	199/9376	0.611122558398688	P2RX2/ADCY9/GNAI1/PLCB1/GABRE/OGFR/PRKCA/GNB5/GNG12/SLC17A9/GNAI3/GNB2/GNB1/GNB4/GNG5/PLCB3/SLC1A3/ADCY3/GNGT1/GABBR1/GNA11/ADORA2B/ADRA2C/ADCY6/OGFRL1/GNAS/ADRA2A/HTR1B/GLRB/ADORA1/P2RX6	-3.24309164416108
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/2390	160/9376	0.563933054393305	F11R/NEGR1/NFASC/CLDN23/HLA-F/NRCAM/NECTIN3/PVR/JAM3/SDC4/ITGAV/NCAM2/SDC2/CD58/CADM1/NRXN2/ITGA9/CLDN15/NECTIN1/OCLN/CLDN12/PTPRM/NEO1	-3.25396010653152
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/2390	39/9376	0.201180130887244	FAS/HLA-F	-2.92380080076417
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/2390	68/9376	0.346148166379523	RDH10/HSD17B6/RDH11/CYP2W1/CYP3A5/ADH1B	-3.16501602345503
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/2390	31/9376	0.126548792009718	UGDH	-2.84905046466723
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/2390	100/9376	0.431531380753138	IL10RB/IL18R1/TNFRSF10D/CSF1/TNFRSF1A/IL6/CCL13/ACKR3/CXCL10/TNFRSF10B/CXCL1	-3.34269247498771
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/2390	41/9376	0.191366465965915	GABRE/CACNA1A	-3.03498684372138
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/2390	70/9376	0.336258218768679	GSTT2B/SULT1A1/HSD11B1/CYP3A5/NAT1/PTGS2	-3.26014525518998
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/2390	50/9376	0.235380753138075	IL15RA/IL15/IL6	-3.17068297322634
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/2390	44/9376	0.17831875237733	FAS/HLA-F	-3.19530741216699
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/2390	54/9376	0.217945141794514	FAS/HLA-F/TSHR	-3.37093087506085
Genetic Information Processing	Translation	hsa03010	Ribosome	31/2390	222/9376	0.54780805910513	RPL17/RPL36A/RPS10/MRPL42/MRPS22/MRPL32/RPL22L1/MRPS6/MRPS5/MRPS31/MRPS28/MRPL50/MRPL39/MRPS18C/RPS21/MRPL49/MRPL38/MRPL18/MRPL22/RSL24D1/MRPL30/MRPL35/MRPL44/MRPS17/MRPL47/MRPL53/MRPL3/MRPL17/RPS27L/MRPL10/DAP3	-3.98808264074498
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/2390	73/9376	0.268699489883648	GSTT2B/CYP3A5/MAOB/ADH1B/FMO4	-3.66873289682699
NA	NA	hsa04382	Cornified envelope formation	29/2390	217/9376	0.524273566897403	UGCG/ABHD5/SPTLC1/PPP2CB/PPP2R2D/CLDN23/PPP2R2A/PPP2R3C/PPP2R1B/KDSR/LAMA5/COL4A1/PPP2CA/PCSK6/KRT10/PPP2R5A/PPP2R5E/CLDN15/PPP2R3A/OCLN/KAZN/CLDN12/COL4A2/KRT8/PPP2R3B/EPHX2/KRT82/KRT18/PPP2R5B	-4.14699410987376
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/2390	79/9376	0.198633546951962	GSTT2B/HSD11B1/CYP3A5/ADH1B	-4.18353672861505
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/2390	99/9376	0.118879168251553	CFB/KRT10/KRT18	-5.15489218156677
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	40/2390	370/9376	0.424109465113649	P2RX2/PTGER2/ADM/THRB/LYPD6/PGRMC2/GABRE/PGRMC1/OGFR/CYSLTR2/PTGIR/LEPR/PTGFR/BDKRB1/LPAR1/S1PR3/VIPR2/UCN/GABBR1/PTH1R/EDNRB/ADORA2B/ADRA2C/SSTR2/OGFRL1/NR3C1/TRPV1/HCRTR2/ADRA2A/CHRNB1/MAS1/OXTR/TSHR/S1PR5/HTR1B/MC1R/GLRB/ADORA1/SCT/P2RX6	-6.61066469388133
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/2390	143/9376	0.109734616847588	TRIM21/ACTN1/ACTN4/C7	-6.27460491985156
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	14/2390	449/9376	0.122321104080663	CAMK2D/PRKG1/GNB1/SLC8A1/ADCY3/OR4D9/OR10K1/OR52H1/CALM2/OR3A3/PDE1C/OR51M1/OR5AS1/OR1I1	-11.1474711451061