category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	49/1106	142/9376	2.92529862720628	SOCS3/UBE2B/BIRC2/CBLB/UBE2J1/BIRC3/CUL3/HERC2/CUL1/UBA6/UBE2N/UBE2A/UBE2D3/HERC4/ELOC/CUL2/UBA2/TRIP12/COP1/ANAPC16/SOCS1/UBR5/CDC27/UBC/SKP1/UBE2D1/UBE2J2/BIRC6/WWP1/RCHY1/UBE2H/RNF7/PIAS2/CUL4B/FBXO2/UBE2E3/UBE2F/UBE4A/HUWE1/NEDD4/UBE2S/UBE4B/UBE2Q1/SMURF1/ANAPC10/CDC26/DDB1/KLHL9/DDB2	8.45391321420553
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	51/1106	174/9376	2.48475400636029	ERO1B/KRTCAP2/NFE2L2/XBP1/EDEM1/SVIP/STT3B/SEC61G/UBXN2A/UBE2J1/SAR1A/HSPA4L/CUL1/UBE2D3/SEC23A/SAR1B/ERO1A/DNAJB12/TMEM258/LMAN1/DNAJC3/DERL1/RPN2/SEC24C/SEC62/PDIA4/TRAM1/SKP1/SEC24B/MOGS/UBE2D1/CALR/UBE2J2/NPLOC4/GANAB/UBQLN1/VCP/FBXO2/EIF2S1/PDIA3/DNAJB11/PLAA/UBE4B/ATXN3/DDOST/MAGT1/DDIT3/STT3A/MBTPS1/UBQLN2/MAPK8	7.22933687153662
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	83/1106	368/9376	1.91202138532904	NDUFA13/PSMA2/NUP98/VDAC1/UQCR11/PSMD9/NDUFB8/NDUFV2/PSMA6/XBP1/HNRNPA1/PPP3R1/CYCS/DCTN6/MAP1LC3B/NDUFA7/NDUFC1/NUP54/NDUFC2/RAB5A/UQCRFS1/PSMA1/NUP58/RANBP2/TANK/TUBB2A/PSMD12/COX6C/NDUFA3/DCTN4/ATG13/RAB1A/NDUFA11/OPTN/NUP205/MT-ND4L/NDUFB1/CASP1/NUP153/COX7C/CASP3/NDUFA1/SOD1/TUBB4B/VAPB/PIK3C3/DERL1/KLC1/NUP210/TARDBP/PSMC6/NDUFV3/NDUFB3/ATP5F1E/NUP160/PSMA3/NUP50/PSMD14/ULK1/TP53/UBQLN1/PPP3CA/SDHB/VCP/PSMC4/EIF2S1/NDUFB9/NXT1/SDHD/NDUFA5/PSMD6/BECN1/NDUFB6/NDUFB5/CHMP2B/KIF5C/DDIT3/COX7A2L/NCBP1/HNRNPA3/UBQLN2/NUP85/SRSF3	6.5271739882253
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	36/1106	108/9376	2.82579867389994	NUP98/SENP2/KPNA5/XPO4/RBM8A/EIF4A3/NUP54/KPNA1/DDX19A/EEF1A1/SUMO1/NUP58/RANBP2/THOC3/MAGOH/DDX39B/NUP205/RANGAP1/IPO5/NUP153/NMD3/NUP210/KPNA4/THOC1/TNPO3/NUP160/NUP50/TMEM33/IPO4/SAP18/NXT1/PHAX/RNPS1/NCBP1/TNPO1/NUP85	6.97882325235866
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	34/1106	103/9376	2.79836373531839	PPP1CB/PABPC1/CSTF2T/ETF1/RBM8A/PPP2R3C/DAZAP1/EIF4A3/PPP2R5C/DDX19A/PABPN1/SMG1/GSPT1/RNMT/MSI2/MAGOH/DDX39B/PPP2R2A/HBS1L/CPSF6/PPP2R2D/PPP2R1B/TARDBP/CSTF2/PABPC4/PELO/PPP2CA/SMG5/SAP18/NXT1/PAPOLG/RNPS1/NCBP1/CPSF1	6.71114258029555
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	53/1106	205/9376	2.19171702024434	PLCG2/IRF7/RELB/IRF9/TAP1/HLA-C/B2M/NFKB2/JAK3/STAT2/AKT2/STAT1/CYCS/EIF2AK2/STAT3/RUNX3/RELA/NFKB1/CDKN1A/RIPK1/PSMD12/SIN3A/IFNAR1/IKBKB/HDAC1/CCND2/USP7/CASP3/PIK3CA/AKT3/RB1/HLA-B/FAS/IRAK1/MYC/TAPBP/IRAK4/TRAF3/PSMC6/CALR/BCL2L11/PSMD14/TP53/NFKBIB/PSMC4/NEDD4/PSMD6/PDIA3/SAP30/TAP2/MAPK8/CCND3/DDB2	6.30887863296781
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/1106	157/9376	2.32183457919167	NDUFA13/SOCS3/UQCR11/NDUFB8/NDUFV2/XBP1/AKT2/CYCS/CDC42/NDUFA7/NDUFC1/NDUFC2/UQCRFS1/RELA/TGFB1/NFKB1/IRS2/COX6C/NDUFA3/NDUFA11/NDUFB1/IKBKB/COX7C/CASP3/NDUFA1/PIK3CA/AKT3/FAS/NDUFV3/PRKAA1/NDUFB3/BCL2L11/SDHB/EIF2S1/NDUFB9/SDHD/NDUFA5/NDUFB6/NDUFB5/ADIPOR2/DDIT3/COX7A2L/MAPK8	6.10795001700968
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	47/1106	180/9376	2.21354229455495	IFNGR1/PPP1CB/SOCS3/IRF7/SRSF6/IRF9/BIRC2/TAP1/HLA-C/B2M/STAT2/AKT2/STAT1/CYCS/EIF2AK2/PILRB/BIRC3/RELA/RHEB/NFKB1/ZC3HAV1/IFNAR1/IKBKB/CASP3/PIK3CA/AKT3/HLA-B/FAS/IRAK1/TAPBP/SRSF9/IRAK4/SRSF5/TRAF3/IFNGR2/SRSF1/EIF2B1/CALR/TP53/EIF2S1/SRSF2/SP100/PDIA3/NECTIN1/PTPN11/TAP2/SRSF3	6.01176693132413
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	42/1106	156/9376	2.28237585199611	SOCS3/IRF7/MX1/CTNNB1/IRF9/KRAS/BRAF/LDLR/MX2/STAT2/AKT2/STAT1/CYCS/EIF2AK2/STAT3/SOS2/RELA/NFKB1/CDKN1A/RIPK1/RSAD2/YWHAE/PPP2R2A/IFNAR1/IKBKB/CASP3/PIK3CA/AKT3/PPP2R2D/RB1/YWHAQ/FAS/IFIT1/MYC/PPP2R1B/TRAF3/PPP2CA/RAF1/YWHAG/TP53/EIF2S1/CLDN1	5.90639675651864
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	80/1106	388/9376	1.74791670550512	NDUFA13/PSMA2/CTNNB1/KRAS/BRAF/VDAC1/UQCR11/PSMD9/NDUFB8/NDUFV2/PSMA6/XBP1/AKT2/PPP3R1/CYCS/EIF2AK2/CALM2/NDUFA7/NDUFC1/NDUFC2/NAE1/UQCRFS1/RELA/PSMA1/NFKB1/CALM3/IRS2/TUBB2A/PSMD12/CSNK1E/ATP2A2/VDAC2/COX6C/NDUFA3/ATG13/NDUFA11/MT-ND4L/NDUFB1/IKBKB/COX7C/CASP3/NDUFA1/PIK3CA/AKT3/FAS/TUBB4B/PIK3C3/ADAM17/KLC1/VDAC3/CSNK1A1/PSMC6/NDUFV3/RAF1/NDUFB3/ATP5F1E/PSEN1/WNT7A/PSMA3/PSMD14/ULK1/PPP3CA/SDHB/PSMC4/EIF2S1/NDUFB9/RTN3/SDHD/NDUFA5/FRAT1/PSMD6/BECN1/NOX4/NDUFB6/NDUFB5/KIF5C/DDIT3/COX7A2L/FRAT2/MAPK8	5.50234746019888
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	27/1106	83/9376	2.7577071395891	OGT/CBX6/PHF1/ASXL1/RYBP/FOXK1/PCGF5/USP16/AEBP2/JARID2/EZH2/UBE2D3/BCOR/HDAC1/FBRSL1/SCML1/USP7/KDM2B/SKP1/SFMBT2/UBE2D1/TFDP1/SFMBT1/PHC1/KDM2A/L3MBTL3/EED	5.88190548031771
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	60/1106	268/9376	1.89792448247011	NDUFA13/PSMA2/VDAC1/UQCR11/PSMD9/NDUFB8/NDUFV2/NFE2L2/PSMA6/XBP1/CYCS/CALM2/NDUFA7/NDUFC1/UBE2J1/NDUFC2/UQCRFS1/PSMA1/CALM3/TUBB2A/PSMD12/VDAC2/COX6C/NDUFA3/GNAS/NDUFA11/MT-ND4L/NDUFB1/COX7C/CASP3/NDUFA1/SOD1/TUBB4B/KLC1/VDAC3/PSMC6/UBC/NDUFV3/NDUFB3/ATP5F1E/UBE2J2/PSMA3/GNAI3/CAMK2G/PSMD14/TP53/SDHB/GNAI1/PSMC4/EIF2S1/NDUFB9/SDHD/NDUFA5/PSMD6/NDUFB6/NDUFB5/KIF5C/DDIT3/COX7A2L/MAPK8	5.4538871318966
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	93/1106	480/9376	1.64249547920434	NDUFA13/PSMA2/CTNNB1/KRAS/BRAF/VDAC1/UQCR11/PSMD9/NDUFB8/NDUFV2/PSMA6/XBP1/PPP3R1/CYCS/CALM2/DCTN6/MAP1LC3B/NDUFA7/NDUFC1/UBE2J1/NDUFC2/RAB5A/UQCRFS1/RELA/IFT57/PSMA1/NFKB1/TANK/CALM3/PRNP/TUBB2A/PSMD12/CSNK1E/ATP2A2/VDAC2/COX6C/NDUFA3/DCTN4/ATG13/RAB1A/NDUFA11/OPTN/MT-ND4L/NDUFB1/PRKCA/COX7C/CASP3/NDUFA1/SOD1/FAS/TUBB4B/VAPB/PIK3C3/DERL1/KLC1/VDAC3/CSNK1A1/TARDBP/PSMC6/UBC/NDUFV3/RAF1/NDUFB3/ATP5F1E/PSEN1/ATXN1/WNT7A/UBE2J2/PSMA3/CAMK2G/PSMD14/ULK1/PPP3CA/SDHB/VCP/PSMC4/EIF2S1/NDUFB9/SDHD/NDUFA5/FRAT1/PSMD6/BECN1/NOX4/NDUFB6/NDUFB5/ATXN3/CHMP2B/KIF5C/DDIT3/COX7A2L/FRAT2/MAPK8	5.28449820429944
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	66/1106	308/9376	1.81658486179282	NDUFA13/PSMA2/TAF4B/SOD2/VDAC1/UQCR11/PSMD9/NDUFB8/NDUFV2/PSMA6/CYCS/DCTN6/NDUFA7/NDUFC1/NDUFC2/BBC3/UQCRFS1/IFT57/PSMA1/POLR2K/TUBB2A/PSMD12/VDAC2/SIN3A/COX6C/NDUFA3/DCTN4/ATG13/NDUFA11/MT-ND4L/NDUFB1/POLR2J3/HDAC1/COX7C/CASP3/NDUFA1/SOD1/TUBB4B/PIK3C3/POLR2C/KLC1/VDAC3/NRF1/PSMC6/NDUFV3/NDUFB3/ATP5F1E/POLR2L/PSMA3/PSMD14/ULK1/TP53/SDHB/PSMC4/NDUFB9/SDHD/NDUFA5/PSMD6/BECN1/POLR2B/NDUFB6/NDUFB5/TFAM/KIF5C/COX7A2L/MAPK8	5.32882396710879
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/1106	227/9376	1.94195856003696	NDUFA13/KRAS/SOD2/BRAF/HIF1A/VDAC1/UQCR11/NDUFB8/NDUFV2/NFE2L2/AKT2/NDUFA7/NDUFC1/SOS2/NDUFC2/UQCRFS1/RELA/NFKB1/VDAC2/COX6C/NDUFA3/NDUFA11/MT-ND4L/NDUFB1/IKBKB/COX7C/NDUFA1/SOD1/PIK3CA/AKT3/PTPN1/ARNT/VDAC3/PRKD3/NDUFV3/RAF1/NDUFB3/ATP5F1E/SDHB/AHR/ABL2/NDUFB9/SDHD/PDPK1/NDUFA5/NOX4/NDUFB6/NDUFB5/PTPN11/ACP1/COX7A2L/MAPK8	5.2537373682859
Human Diseases	Infectious disease: viral	hsa05162	Measles	36/1106	136/9376	2.24401659397936	IRF7/MX1/IRF9/MX2/JAK3/STAT2/AKT2/CBLB/STAT1/CYCS/EIF2AK2/IL2RB/STAT3/BBC3/RELA/NFKB1/ADAR/STAT5B/IFNAR1/IKBKB/CCND2/CASP3/PIK3CA/AKT3/FAS/IRAK1/IRAK4/CD28/TRAF3/RCHY1/TP53/NFKBIB/SLAMF1/EIF2S1/MAPK8/CCND3	5.34404478401451
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	46/1106	196/9376	1.98959294386832	PLCG2/IFNGR1/IRF7/CTNNB1/IRF9/KRAS/HLA-C/CLEC2B/HIF1A/STAT2/AKT2/PPP3R1/GNB5/STAT1/CYCS/EIF2AK2/CALM2/ZFP36/MAP1LC3B/STAT3/GNG2/RELA/NFKB1/CDKN1A/CALM3/NFATC1/GNG8/IFNAR1/IKBKB/CASP3/PIK3CA/AKT3/RB1/HLA-B/FAS/PIK3C3/MYC/TRAF3/UBC/RAF1/PREX1/MICA/TP53/PPP3CA/BECN1/MAPK8	5.12004445711315
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	49/1106	214/9376	1.94108600496865	PLCG2/KRAS/TAP1/HLA-C/B2M/AKT2/PPP3R1/GNB5/CYCS/CALM2/CFL2/GNG2/RELA/NFKB1/RIPK1/CUL1/CALM3/NFATC1/GNG8/AP1G1/AP1G2/ELOC/IKBKB/PRKCA/CASP3/PIK3CA/AKT3/HLA-B/FAS/IRAK1/TAPBP/IRAK4/SKP1/RPS6KB2/RAF1/PXN/CALR/GNAI3/RNF7/PPP3CA/CUL4B/GNAI1/TRIM5/RPS6KB1/PDIA3/DDB1/TAP2/MAPK8/ATR	5.09274000226213
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	33/1106	122/9376	2.29306613701716	ITK/NCK2/KRAS/VAV1/ICOS/AKT2/CBLB/PPP3R1/CDC42/PPP2R3C/VAV3/BCL10/SOS2/MALT1/PPP2R5C/RELA/NFKB1/NFATC1/PPP2R2A/IKBKB/PIK3CA/AKT3/PPP2R2D/PRKCQ/PPP2R1B/CD28/PPP2CA/RAF1/PPP3CA/NFKBIB/PDPK1/PTPN11/MAPK8	5.2571013915853
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	40/1106	163/9376	2.08034258201223	STAT4/IRF7/KRAS/BRAF/JAK3/STAT2/AKT2/STAT1/CYCS/STAT3/SOS2/RELA/TGFB1/NFKB1/CDKN1A/NFATC1/STAT5B/IFNAR1/IKBKB/PRKCA/CASP3/PIK3CA/AKT3/RB1/YWHAQ/ELK1/FAS/IRAK1/MYC/VDAC3/IRAK4/TRAF3/SMAD4/RAF1/TP53/STAT6/DDX3X/DDB1/MAPK8/DDB2	5.08821211635719
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	52/1106	238/9376	1.85220417280836	RPS10/RPL17/RPS21/RPL36A/RPS29/RPS27/PLCG2/RPL26/RPL41/RPL39/RPL37/RPL38/RPL34/MX1/IRF9/RPS15A/RPS17/MX2/STAT2/RPS25/STAT1/EIF2AK2/RPL36/RPL35A/STAT3/RSL24D1/RPL22/RPL30/RELA/RPL32/NFKB1/RPL6/RPL14/RPS28/ADAR/IFNAR1/CASP1/IKBKB/PRKCA/RPL22L1/PIK3CA/ADAM17/IRAK1/IRAK4/TRAF3/RPL36AL/RPL37A/NFKBIB/RPL5/RPL27/RPS27L/MAPK8	4.86986592936183
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	35/1106	138/9376	2.15006420840213	PPP1CB/SOCS3/PDE3B/PHKG1/KRAS/BRAF/AKT2/CBLB/CALM2/MKNK2/FASN/SOS2/EIF4E/RHEB/CALM3/IRS2/PYGM/ACACA/IKBKB/FOXO1/PIK3CA/AKT3/PTPN1/SOCS1/ELK1/SOCS4/RPS6KB2/PRKAA1/RAF1/PPP1R3B/RPS6KB1/PDPK1/PHKA2/MAPK8/HK1	4.97717715383468
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	41/1106	173/9376	2.00909385485371	IFNGR1/SOCS3/IRF7/MX1/IRF9/MX2/NUP98/KPNA5/VDAC1/STAT2/AKT2/STAT1/CYCS/EIF2AK2/KPNA1/PABPN1/RELA/NFKB1/HNRNPUL1/RSAD2/ADAR/IFNAR1/CASP1/IKBKB/PRKCA/CASP3/PIK3CA/AKT3/FAS/DNAJC3/IRAK4/TRAF3/IFNGR2/RAF1/TRIM25/RAB11A/TNFRSF10B/NFKBIB/EIF2S1/NXT1/CCND3	4.8989200164664
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	49/1106	224/9376	1.85443037974684	RELB/KRAS/HLA-C/B2M/NFKB2/VDAC1/CRTC3/JAK3/AKT2/PPP3R1/IL2RB/ZFP36/ELK4/RELA/TGFB1/NFKB1/CDKN1A/NFATC1/VDAC2/STAT5B/IKBKB/CCND2/PIK3CA/AKT3/ANAPC16/RB1/ELK1/HLA-B/POLB/BUB3/MYC/VDAC3/CDC27/TRRAP/MAP3K3/SMAD4/TCF3/ETS1/CALR/SMAD2/TP53/PPP3CA/CRTC2/ANAPC10/CDC26/MAPK8/ADCY2/ATR/CCND3	4.73318121137508
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1106	87/9376	2.43603333956891	CTNNB1/KRAS/BRAF/AKT2/CYCS/SOS2/BBC3/TGFB1/CDKN1A/CASP3/PIK3CA/AKT3/MYC/RALGDS/RPS6KB2/SMAD4/RAF1/MSH6/BCL2L11/SMAD2/TP53/RPS6KB1/MAPK8/AREG/DDB2	4.92096316905006
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	23/1106	77/9376	2.53220920128696	KRAS/BRAF/AKT2/STAT1/CDC42/STAT3/RELA/TGFB1/NFKB1/CDKN1A/IKBKB/PIK3CA/AKT3/RB1/RALGDS/RPS6KB2/SMAD4/RAF1/SMAD2/TP53/RPS6KB1/MAPK8/DDB2	4.93691615674265
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	23/1106	78/9376	2.49974498075764	PABPC1/DDX6/EXOSC6/PAN3/CNOT1/CNOT2/CNOT6L/CNOT9/DIS3/DCP1A/TENT4B/C1D/XRN2/MTREX/CNOT7/TENT4A/PNPT1/CNOT10/PABPC4/HSPA9/ZCCHC7/EXOSC3/MPHOSPH6	4.86385248117047
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	28/1106	105/9376	2.26063893911995	PLCG2/BCL3/RELB/IRF9/KRAS/NFKB2/STAT2/AKT2/CBLB/PPP3R1/STAT1/CALM2/IRF1/BCL10/MALT1/RELA/NFKB1/CALM3/NFATC1/CASP1/IKBKB/PIK3CA/AKT3/RAF1/PPP3CA/CYLD/PTPN11/MAPK8	4.7504256316767
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	25/1106	90/9376	2.35483222824995	BATF/IFNGR1/KRAS/HIF1A/AKT2/PPP3R1/STAT1/STAT3/RELA/NFKB1/NFATC1/IKBKB/PIK3CA/AKT3/PRKCQ/CD28/IFNGR2/MAP3K3/RPS6KB2/RAF1/EML4/PPP3CA/NFKBIB/RPS6KB1/PTPN11	4.72283617278153
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	30/1106	120/9376	2.11934900542495	PLCG2/KRAS/BRAF/AKT2/CALM2/CDC42/SOS2/RELA/NFKB1/CALM3/RIPK2/YWHAE/RAP1A/IKBKB/PIK3CA/AKT3/RAP1B/RPS6KA5/IRAK1/RPS6KA3/IRAK4/MAP3K3/RAF1/PSEN1/CAMK2G/TP53/NFKBIB/PDPK1/PTPN11/MAPK8	4.51289173317967
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	38/1106	169/9376	1.90616005221653	KRAS/HIF1A/AKT2/MAP1LC3B/GABARAP/RHEB/TANK/IRS2/ATG13/RAB1A/PLEKHM1/OPTN/WDR45B/PIK3CA/AKT3/PRKCQ/PIK3C3/RAB33B/LAMP2/UBC/RPS6KB2/PPP2CA/PRKAA1/SUPT20H/RAF1/ATG12/GORASP2/MTMR3/BIRC6/ATG5/ULK1/ATG4B/EIF2S1/DDIT4/RPS6KB1/PDPK1/BECN1/MAPK8	4.34710009429113
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	36/1106	157/9376	1.94386150816047	PPP1CB/KRAS/HLA-C/HIPK1/VDAC1/SIRT1/AKT2/PPP3R1/CALM2/RELA/TGFB1/RHEB/NFKB1/CDKN1A/RBL1/CALM3/NFATC1/VDAC2/FOXO1/CCND2/PIK3CA/AKT3/RB1/HLA-B/TRPM7/MYC/VDAC3/RAD1/RAF1/ETS1/SMAD2/TP53/PPP3CA/E2F4/ATR/CCND3	4.36140724836308
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	30/1106	122/9376	2.08460557910651	SIRT1/AKT2/PFKFB3/PPP2R3C/FASN/PPP2R5C/RHEB/CPT1A/IRS2/ACACA/PPP2R2A/FOXO1/PIK3CA/AKT3/PPP2R2D/ELAVL1/TBC1D1/PPP2R1B/CAB39/RPS6KB2/PPP2CA/PRKAA1/HMGCR/ULK1/RAB14/RPS6KB1/PDPK1/CRTC2/STRADB/ADIPOR2	4.40958226034369
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/1106	248/9376	1.7091524237298	SNX9/ARPC1B/CTNNB1/BIRC2/ARF6/CYTH1/ELMO2/AKT2/CYCS/DCTN6/CDC42/ARHGEF26/KPNA1/DNM2/RAB5A/BIRC3/RELA/DYNLT3/NFKB1/RIPK1/DYNLT1/TUBB2A/RIPK2/DCTN4/PLEKHM1/CASP1/IKBKB/CASP3/PIK3CA/AKT3/M6PR/PIK3C2B/TUBB4B/PIK3C3/IRAK1/KLC1/MYC/KPNA4/EXOC2/IRAK4/SKP1/RAF1/PIK3C2A/ACBD3/CYTH2/TNFRSF10B/ACTR3C/KIF5C/FYCO1/MAPK8	4.13892982610493
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	43/1106	205/9376	1.77818550699069	NDUFA13/PPP1CB/VDAC1/UQCR11/NDUFB8/NDUFV2/AKT2/NDUFA7/NDUFC1/NDUFC2/UQCRFS1/RELA/TGFB1/NFKB1/MPC1/ATP2A2/VDAC2/COX6C/NDUFA3/NDUFA11/MT-ND4L/NDUFB1/PRKCA/COX7C/NDUFA1/PIK3CA/AKT3/VDAC3/GFPT1/NDUFV3/NDUFB3/ATP5F1E/MPC2/SMAD2/CAMK2G/SDHB/NDUFB9/SDHD/NDUFA5/NDUFB6/NDUFB5/COX7A2L/MAPK8	4.11966753359971
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	27/1106	109/9376	2.09990543656785	IFNGR1/HIF1A/JAK3/PPP3R1/STAT1/IL2RB/IL4R/STAT3/RELA/TGFB1/NFKB1/NFATC1/STAT5B/IL21R/RORA/IKBKB/IRF4/PRKCQ/IFNGR2/SMAD4/SMAD2/PPP3CA/NFKBIB/AHR/STAT6/IL27RA/MAPK8	4.22385949402374
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	27/1106	109/9376	2.09990543656785	PPP1CB/SOCS3/OGT/AKT2/STAT3/RELA/NFKB1/CPT1A/IRS2/PYGM/NR1H2/IKBKB/FOXO1/PIK3CA/AKT3/PTPN1/PRKCQ/RPS6KA3/GFPT1/RPS6KB2/PRKAA1/PPP1R3B/RPS6KB1/PDPK1/CRTC2/PTPN11/MAPK8	4.22385949402374
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/1106	110/9376	2.0808153871445	PLCG2/IFNGR1/LDHA/PGK1/HIF1A/AKT2/PFKFB3/MKNK2/STAT3/ALDOA/EIF4E/RELA/NFKB1/CDKN1A/ELOC/CUL2/PRKCA/PIK3CA/AKT3/ARNT/FLT1/IFNGR2/RPS6KB2/CAMK2G/RPS6KB1/PDK1/HK1	4.16977057675413
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	46/1106	227/9376	1.71788641849424	CTNNB1/KRAS/TAP1/HLA-C/B2M/AKT2/PPP3R1/GNB5/CYCS/CALM2/STAT3/GNG2/SOS2/RELA/RHEB/NFKB1/CDKN1A/RIPK1/CALM3/NFATC1/GNG8/GNAS/IKBKB/PRKCA/CASP3/PIK3CA/AKT3/RB1/PTGER4/ELK1/HLA-B/FAS/MYC/TAPBP/RPS6KB2/RAF1/PXN/CALR/GNAI3/TP53/PPP3CA/GNAI1/RPS6KB1/PDIA3/TAP2/ADCY2	4.0039836814903
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/1106	77/9376	2.31201709682722	KRAS/BRAF/AKT2/SOS2/RELA/TGFB1/NFKB1/CDKN1A/STAT5B/IKBKB/HDAC1/PIK3CA/AKT3/RB1/MYC/SMAD4/RAF1/TP53/CTBP1/PTPN11/DDB2	4.22743734850852
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/1106	275/9376	1.63382541509124	NDUFA13/PSMA2/VDAC1/UQCR11/PSMD9/NDUFB8/NDUFV2/PSMA6/PPP3R1/CYCS/NOTCH1/NDUFA7/NDUFC1/NDUFC2/UQCRFS1/PSMA1/PRNP/TUBB2A/PSMD12/VDAC2/COX6C/NDUFA3/NDUFA11/MT-ND4L/NDUFB1/COX7C/CASP3/NDUFA1/SOD1/PIK3CA/TUBB4B/KLC1/VDAC3/PSMC6/NDUFV3/NDUFB3/ATP5F1E/PSMA3/PSMD14/PPP3CA/SDHB/PSMC4/EIF2S1/NDUFB9/SDHD/NDUFA5/PSMD6/NDUFB6/NDUFB5/KIF5C/DDIT3/COX7A2L/MAPK8	3.90123297267436
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/1106	250/9376	1.66156962025316	ARPC1B/HLA-C/LDLR/ARF6/ARF4/CYTH1/SMAP2/CBLB/IL2RB/CDC42/EHD4/RAB11FIP4/ZFYVE27/DNM2/RAB5A/ARFGEF1/CAPZA1/ARF5/CAPZA2/IST1/ARFGAP3/WASHC2A/PDCD6IP/HLA-B/EPS15/GRK5/GRK6/ARFGAP2/WASHC4/CHMP3/PARD6A/VPS26A/SNX3/RAB11A/CYTH2/WWP1/VPS26B/SMAD2/VPS37B/VPS4A/NEDD4/ARFGEF2/ACTR3C/RAB22A/CHMP2B/SMURF1/KIF5C/RAB11FIP2/CHMP1B	3.8771782957826
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	42/1106	205/9376	1.73683235566533	GTF2H2/IRF7/HDAC4/IRF9/KRAS/GTF2B/HLA-C/NFKB2/JAK3/EIF2AK2/CDC42/STAT3/GTF2H2C/RELA/NFKB1/CDKN1A/RBL1/TRAF1/YWHAE/STAT5B/HDAC1/CCND2/USP7/CASP3/PIK3CA/DNAJA3/RB1/YWHAQ/HLA-B/HNRNPK/POLB/VDAC3/RASA2/TRAF3/PXN/YWHAG/TP53/HDAC10/DDX3X/SP100/DDB1/CCND3	3.9007464236629
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	29/1106	125/9376	1.96675587703436	ABCC1/KRAS/AKT2/PPP2R3C/PPP2R5C/RELA/S1PR1/NFKB1/PPP2R2A/DEGS1/CERS2/PRKCA/PIK3CA/AKT3/PPP2R2D/PPP2R1B/SMPD1/NSMAF/DEGS2/PPP2CA/RAF1/CERS5/GNAI3/TP53/GNAI1/CERS6/PDPK1/SPHK1/MAPK8	3.97912822106631
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	30/1106	133/9376	1.91219459136086	KRAS/SOD2/BRAF/CDKN2D/FBXO32/SIRT1/AKT2/STAT3/SOS2/TGFB1/GABARAP/S1PR1/CDKN1A/IRS2/CSNK1E/IKBKB/FOXO1/CCND2/USP7/PIK3CA/AKT3/SGK1/FBXO25/SMAD4/PRKAA1/RAF1/ATG12/BCL2L11/PDPK1/MAPK8	3.87451443936232
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	34/1106	158/9376	1.82424977682148	CDKN2D/PPP2R5C/TGFB1/CDKN1A/CUL1/RBL1/YWHAE/HDAC1/CCND2/ANAPC16/ORC4/RB1/CCNH/YWHAQ/BUB3/MYC/PPP2R1B/CDC27/SKP1/SMAD4/PPP2CA/DBF4/YWHAG/SMAD2/WAPL/TFDP1/TP53/STAG1/CDC14A/ANAPC10/CDC26/E2F4/ATR/CCND3	3.82102145904145
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	19/1106	70/9376	2.30100749160424	KRAS/BRAF/HIF1A/AKT2/CDC42/SOS2/TGFB1/CDKN1A/ELOC/RAP1A/CUL2/PIK3CA/AKT3/RAP1B/ARNT/RAF1/ETS1/FH/PTPN11	3.995376769886
Genetic Information Processing	Transcription	hsa03040	Spliceosome	47/1106	243/9376	1.63966095892959	DDX5/SRSF6/TRA2A/PHF5A/HNRNPA1/RBM8A/EIF4A3/BCAS2/SNRPA1/WBP11/SNRNP27/THOC3/SF3A2/MAGOH/DDX39B/BUD31/RBMXL1/AQR/SNRPG/PRPF18/HNRNPK/DHX8/SNRPB2/THOC1/DHX15/RBMX/SRSF9/SART1/SRSF5/SF3B3/SRSF1/SNIP1/CWC15/HNRNPM/SRSF10/SF3A1/SYF2/U2SURP/CWC25/PRPF4/SRSF2/PLRG1/CCDC12/NCBP1/HNRNPA3/RBM17/SRSF3	3.69450875176558
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	25/1106	105/9376	2.01842762421424	KRAS/CCZ1/HIF1A/CCZ1B/MAP1LC3B/ARIH1/RAB5A/RELA/TOMM7/GABARAP/USP15/OPTN/OPA1/UBC/TOMM20/ULK1/TP53/TBC1D15/VCP/EIF2S1/HUWE1/BECN1/BCL2L13/SMURF1/MAPK8	3.83770843494039
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	35/1106	168/9376	1.76612417118746	IFNGR1/STAT4/IRF9/BIRC2/VDAC1/JAK3/STAT2/STAT1/EIF2AK2/STAT3/DNM1L/BIRC3/RIPK1/PYGM/VDAC2/STAT5B/IFNAR1/CASP1/TRPM7/FAS/VDAC3/USP21/SMPD1/GLUD1/CHMP3/IFNGR2/TNFRSF10B/CAMK2G/CYLD/RBCK1/STAT6/VPS4A/CHMP2B/MAPK8/CHMP1B	3.66422047368804
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/1106	253/9376	1.60835971953198	PLCG2/UBE2V1/ARPC1B/ARF6/CYTH1/VDAC1/ELMO2/AKT2/CYCS/CDC42/MAP1LC3B/BCL10/MALT1/RELA/NFKB1/RIPK1/CUL1/UBE2N/RIPK2/UBE2D3/CASP1/IKBKB/TIFA/FOXO1/PIK3CA/AKT3/RPS6KA5/PRKCQ/GLMN/PIK3C3/PLCE1/UBC/SKP1/RPS6KB2/CAST/ATG12/PXN/CYTH2/UBE2D1/ATG5/TP53/NFKBIB/RBCK1/RPS6KB1/BECN1/ACTR3C/MAPK8/HK1	3.58725559035695
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	16/1106	56/9376	2.42211314905709	KRTCAP2/ALG13/STT3B/FUT8/TMEM258/RPN2/B4GALT1/MOGS/MAN2A1/ALG5/MGAT2/GANAB/MAN2A2/DDOST/MAGT1/STT3A	3.90328853744187
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	16/1106	56/9376	2.42211314905709	NFKB2/CYCS/SAR1A/EEF1A1/EEF1G/SEC22B/RELA/NFKB1/RAB1A/HBS1L/CASP1/SAR1B/CASP3/CLK4/VCP/BCL2L13	3.90328853744187
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/1106	46/9376	2.58007705008255	PSMA2/PSMD9/PSMA6/PSMA1/PSME4/PSMD12/PSMB10/POMP/PSMC6/PSMA3/PSMD14/PSMC4/PSMD6/PSMB8	3.9285004394679
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	31/1106	144/9376	1.82499497689371	PSMA2/GTF2B/VDAC1/PSMD9/PSMA6/XBP1/AKT2/CYCS/PSMA1/PSMD12/ATP2A2/VDAC2/ATG13/OPA1/RORA/PRKCA/PIK3CA/AKT3/PIK3C3/VDAC3/PUM2/PSMC6/ATXN1/PSMA3/PSMD14/ULK1/PSMC4/PSMD6/BECN1/ATXN3/MAPK8	3.64833827419879
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	19/1106	73/9376	2.20644553989447	PLCG2/KRAS/BRAF/JAK3/AKT2/STAT3/SOS2/CDKN1A/STAT5B/PRKCA/PIK3CA/AKT3/RB1/RAF1/TP53/EML4/PDPK1/KIF5C/DDB2	3.78414778358965
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	18/1106	68/9376	2.24401659397936	PIM2/KRAS/BRAF/PIM1/AKT2/STAT3/SOS2/RELA/NFKB1/STAT5B/IKBKB/PIK3CA/AKT3/MYC/RPS6KB2/RAF1/PER2/RPS6KB1	3.76498187163043
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	21/1106	86/9376	2.07006181925228	PLCG2/NCK2/KRAS/BRAF/AKT2/CBLB/SOS2/CDKN1A/STAT5B/PRKCA/PIK3CA/AKT3/ELK1/MYC/RPS6KB2/RAF1/CAMK2G/ABL2/RPS6KB1/MAPK8/AREG	3.6455300617083
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	27/1106	122/9376	1.87614502119586	PLCG2/CTNNB1/KRAS/HIF1A/AKT2/STAT1/NOTCH1/RHEB/ATP1A1/MED4/ATP2A2/SIN3A/HDAC1/FOXO1/MED13/PRKCA/PIK3CA/AKT3/PLCE1/MYC/MED30/RAF1/TP53/MED14/PDPK1/NCOA3/NCOA1	3.56206312910208
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	22/1106	93/9376	2.00540551050963	IFNGR1/STAT4/JAK3/PPP3R1/STAT1/IL2RB/NOTCH1/IL4R/RUNX3/RELA/NFKB1/NFATC1/STAT5B/IKBKB/PRKCQ/IFNGR2/PPP3CA/NFKBIB/MAML2/STAT6/MAPK8/MAML1	3.56327226236209
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	44/1106	235/9376	1.5872571274672	NDUFA13/KRAS/UQCR11/NDUFB8/NDUFV2/NDUFA7/NDUFC1/SOS2/NDUFC2/COX16/UQCRFS1/RHEB/CPT1A/COX6C/NDUFA3/GNAS/NDUFA11/MT-ND4L/NDUFB1/COX20/COX7C/NDUFA1/RPS6KA3/COX11/NDUFV3/RPS6KB2/PRKAA1/NDUFB3/ATP5F1E/SMARCA2/COX19/SDHB/NDUFAF4/NDUFB9/SDHD/RPS6KB1/NDUFA5/SMARCC1/NDUFAF6/NDUFB6/NDUFB5/ACSL3/COX7A2L/ADCY2	3.33407849286966
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1106	71/9376	2.14919899141686	SOCS3/KRAS/AKT2/STAT1/IRF1/STAT3/SOS2/RELA/NFKB1/STAT5B/CCND2/PIK3CA/AKT3/SOCS1/SOCS4/RAF1/GALT/MAPK8	3.55448485974584
Genetic Information Processing	Translation	hsa03010	Ribosome	42/1106	222/9376	1.60383167978105	RPS10/RPL17/RPS21/RPL36A/RPS29/RPS27/RPL26/RPL41/RPL39/RPL37/RPL38/RPL34/RPS15A/RPS17/MRPL53/RPS25/RPL36/RPL35A/MRPL23/RSL24D1/MRPL33/RPL22/RPL30/RPL32/RPL6/MRPL32/RPL14/RPS28/RPL22L1/MRPS30/MRPL19/MRPL1/MRPS22/MRPL48/RPL36AL/MRPS7/RPL37A/MRPS17/RPL5/RPL27/RPS27L/MRPL42	3.32964072252175
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/1106	44/9376	2.50468518822949	KRTCAP2/ALG13/STT3B/FUT8/TMEM258/RPN2/B4GALT1/MAN2A1/MGAT2/MAN2A2/DDOST/MAGT1/STT3A	3.65843266432539
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1106	34/9376	2.742686948197	CSNK1D/NR1D2/BHLHE40/CUL1/CSNK1E/CRY1/RORA/FBXL3/SKP1/PRKAA1/PER2	3.72262553931342
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	41/1106	216/9376	1.6091353559708	IRF7/KRAS/SOD2/LDLR/VAV1/NFE2L2/XBP1/AKT2/PPP3R1/CYCS/CALM2/CDC42/VAV3/STAT3/RELA/NFKB1/TANK/CALM3/NFATC1/RAP1A/CASP1/IKBKB/PRKCA/CASP3/ERO1A/PIK3CA/AKT3/RAP1B/FAS/IRAK1/HSPA4/IRAK4/TRAF3/TNFRSF10B/CAMK2G/TP53/PPP3CA/EIF2S1/PDPK1/DDIT3/MAPK8	3.31209964090614
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	58/1106	333/9376	1.476543451227	MX1/CTNNB1/IRF9/KRAS/HLA-C/MX2/STAT2/AKT2/STAT1/EIF2AK2/CDC42/NOTCH1/IRF1/PPP2R3C/SOS2/PPP2R5C/RELA/RHEB/NFKB1/CDKN1A/RBL1/GNAS/PPP2R2A/MFNG/IFNAR1/IKBKB/HDAC1/FOXO1/CCND2/CASP3/PIK3CA/AKT3/PPP2R2D/RB1/PTGER4/HLA-B/FAS/PPP2R1B/CSNK1A1/TRAF3/PARD6A/RPS6KB2/PPP2CA/RAF1/ATP6V1E2/PXN/PSEN1/WNT7A/TP53/MAML2/ITGA6/RPS6KB1/ITGB7/PATJ/OASL/ATR/CCND3/MAML1	3.23801461013222
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	21/1106	90/9376	1.97805907172996	KRAS/SOD2/SIRT1/AKT2/EIF4E/RELA/RHEB/NFKB1/IRS2/ATG13/FOXO1/PIK3CA/AKT3/RPS6KB2/PRKAA1/ATG5/ULK1/TP53/RPS6KB1/ADIPOR2/ADCY2	3.40943525461455
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/1106	30/9376	2.82579867389994	DLST/OGDH/CS/ACO1/ACO2/IDH3A/SDHB/FH/SDHD/MDH1	3.66278201656724
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	21/1106	91/9376	1.9563221588538	PLCG2/IFITM1/KRAS/VAV1/AKT2/PPP3R1/VAV3/RASGRP3/BCL10/SOS2/MALT1/RELA/NFKB1/NFATC1/IKBKB/PIK3CA/AKT3/RAF1/PPP3CA/NFKBIB/INPP5D	3.3523118166965
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	22/1106	98/9376	1.90308890283057	PLCG2/SYNJ2/INPP4B/CALM2/MTMR6/CALM3/CDS2/PRKCA/PIK3CA/PIK3C2B/PIK3C3/PLCE1/PIP4K2A/PI4KA/PIK3C2A/DGKD/MTMR3/DGKE/ITPKB/INPP5D/IP6K1/SACM1L	3.28644831278373
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/1106	63/9376	2.15298946582853	GTF2H2/GTF2H2C/POLR2K/POLR2J3/CCNH/POLR2C/POLD4/POLD2/POLR2M/POLR2L/XPC/CUL4B/RFC1/POLR2B/DDB1/DDB2	3.35784975187141
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	24/1106	112/9376	1.81658486179282	IFNGR1/BIRC2/LDLR/AKT2/STAT1/CYCS/STAT3/BIRC3/RELA/TGFB1/NFKB1/IKBKB/CASP3/AKT3/SOCS1/IRAK1/IRAK4/IFNGR2/GNAI3/NFKBIB/GNAI1/ITGA6/PDPK1/MAPK8	3.1792267912799
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	28/1106	138/9376	1.7200513667217	NDUFA13/UQCR11/NDUFB8/NDUFV2/CYCS/NDUFA7/NDUFC1/NDUFC2/UQCRFS1/COX6C/NDUFA3/NDUFA11/MT-ND4L/NDUFB1/COX7C/NDUFA1/COX11/NDUFV3/NDUFB3/ATP6V1E2/ATP5F1E/SDHB/NDUFB9/SDHD/NDUFA5/NDUFB6/NDUFB5/COX7A2L	3.11619402277893
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/1106	101/9376	1.84656150967719	PLCG2/KRAS/PIM1/AKT2/STAT1/CDC42/STAT3/RELA/TGFB1/NFKB1/NFATC1/STAT5B/FOXO1/PRKCA/CASP3/PIK3CA/AKT3/PLCE1/SMAD4/SMAD2/NOX4/MAPK8	3.12804284742282
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	36/1106	193/9376	1.58127594187147	PLCG2/CCR7/ITK/KRAS/BRAF/VAV1/JAK3/STAT2/AKT2/GNB5/STAT1/CDC42/VAV3/STAT3/GNG2/SOS2/RELA/NFKB1/GNG8/STAT5B/RAP1A/IKBKB/PIK3CA/AKT3/RAP1B/GRK5/GRK6/RAF1/PXN/PREX1/GNAI3/NFKBIB/GNAI1/CXCR5/DOCK2/ADCY2	2.98386491396394
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	17/1106	72/9376	2.00160739401246	IRF7/RNF125/RELA/NFKB1/RIPK1/TANK/ADAR/IKBKB/OTUD5/TRAF3/ATG12/TRIM25/ATG5/NFKBIB/CYLD/DDX3X/MAPK8	3.11989060403612
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/1106	103/9376	1.81070594638249	IFNGR1/AKT2/RELA/TGFB1/NFKB1/GNAS/PPP2R2A/IKBKB/PIK3CA/AKT3/PPP2R2D/FAS/IRAK1/PPP2R1B/IRAK4/IFNGR2/PPP2CA/CALR/GNAI3/SMAD2/GNAI1/MAPK8	3.02539641453738
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	32/1106	168/9376	1.61474209937139	IFNGR1/SOCS3/STAT4/IRF9/JAK3/STAT2/PIM1/AKT2/STAT1/IL2RB/IL4R/STAT3/SOS2/CDKN1A/STAT5B/IFNAR1/IL21R/CCND2/PIK3CA/AKT3/SOCS1/SOCS4/MYC/PTPN2/IFNGR2/RAF1/PIAS2/STAT6/IL11RA/IL27RA/PTPN11/CCND3	2.94018994735966
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	23/1106	110/9376	1.77254644090087	SKIL/SKI/TGFB1/LEMD3/CUL1/RBL1/SIN3A/HDAC1/SMAD7/TGIF2/MYC/PPP2R1B/SKP1/RPS6KB2/SMAD4/PPP2CA/SMAD2/TFDP1/RPS6KB1/SMAD1/SMURF1/E2F4/ACVR1B	2.98047331372226
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/1106	62/9376	2.05098290847576	KRAS/SOD2/SIRT1/AKT2/IRS2/HDAC1/FOXO1/SOD1/PIK3CA/AKT3/RPS6KB2/PRKAA1/ATG5/RPS6KB1/ADCY2	3.03622413574451
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1106	107/9376	1.74301600446164	LDHA/PDE3B/PHKG1/SIRT1/AKT2/PPP3R1/CALM2/SIK1/SIK2/CPT1A/CALM3/PYGM/ACACA/GNAS/FOXO1/AKT3/PRKAA1/CAMK2G/PPP3CA/CRTC2/PHKA2/ADCY2	2.8267282757755
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/1106	187/9376	1.54134473121815	IRF7/IRF9/BIRC2/VDAC1/STAT2/IFI16/STAT1/MAP1LC3B/DNM1L/BIRC3/RELA/GABARAP/NFKB1/RIPK1/TANK/NLRP1/RIPK2/GBP2/VDAC2/YWHAE/IFNAR1/CASP1/IKBKB/TRPM7/VDAC3/GBP1/IRAK4/TRAF3/ATG12/ATG5/NFKBIB/RBCK1/GBP3/MAPK8	2.73445662400799
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/1106	70/9376	1.93769051924567	SOCS3/AKT2/STAT3/RELA/NFKB1/CPT1A/IRS2/IKBKB/AKT3/PRKCQ/PRKAA1/NFKBIB/PTPN11/ADIPOR2/ACSL3/MAPK8	2.87963516129864
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1106	59/9376	2.01158549667453	CTNNB1/KRAS/BRAF/AKT2/SOS2/CDKN1A/PIK3CA/AKT3/ELK1/MYC/RAF1/TP53/PDPK1/DDB2	2.85036842932844
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1106	170/9376	1.54587809807467	PLCG2/CTNNB1/KRAS/BRAF/PHF10/NFE2L2/AKT2/SOS2/TGFB1/CDKN1A/PRKCA/PIK3CA/AKT3/RB1/BRD7/ELK1/MYC/CSNK1A1/RPS6KB2/SMAD4/RAF1/WNT7A/SMARCA2/SMAD2/TP53/RPS6KB1/FRAT1/SMARCC1/ARID2/FRAT2/DDB2	2.62660696799932
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1106	157/9376	1.56588843712927	PPP1CB/CTNNB1/BIRC2/CSNK1D/TP53BP2/BBC3/BIRC3/TGFB1/CSNK1E/YWHAE/PPP2R2A/SMAD7/CCND2/PPP2R2D/YWHAQ/MYC/MOB1A/PPP2R1B/PARD6A/SMAD4/PPP2CA/NF2/YWHAG/WNT7A/SMAD2/SMAD1/PATJ/AREG/CCND3	2.61486447971648
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1106	137/9376	1.60884888003062	KRAS/BIRC2/AKT2/CYCS/BBC3/BIRC3/RELA/NFKB1/RIPK1/TRAF1/IKBKB/CASP3/PIK3CA/AKT3/FAS/RAF1/CASP2/TNFRSF10B/BCL2L11/TP53/EIF2S1/PDPK1/LMNB1/DDIT3/LMNB2/MAPK8	2.62523241721661
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/1106	32/9376	2.38426763110307	BIRC2/CYCS/BBC3/BIRC3/CASP3/BIRC6/BCL2L11/BECN1/MAPK8	2.86839584617704
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1106	99/9376	1.71260525690905	KRAS/GPCPD1/HIF1A/AKT2/SOS2/CHKB/RHEB/PRKCA/PIK3CA/AKT3/CHKA/RALGDS/RPS6KB2/RAF1/DGKD/CHPT1/RPS6KB1/PDPK1/DGKE/MAPK8	2.60659337878235
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	19/1106	93/9376	1.73194112271287	BIRC2/AKT2/CYCS/BIRC3/TRAF4/RELA/NFKB1/CDKN1A/TRAF1/IKBKB/CASP3/PIK3CA/AKT3/RB1/MYC/TRAF3/TP53/ITGA6/DDB2	2.59408315647971
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	35/1106	201/9376	1.47616348636564	DDX5/ETV6/BIRC2/SS18/JMJD1C/IL2RB/NFKBIZ/AFF1/ELK4/BIRC3/RELA/NFKB1/CDKN1A/FUT8/TRAF1/SIN3A/NR4A3/HDAC1/FOXO1/CCND2/HPGD/ZEB1/MYC/FLT1/KDM6A/SUPT3H/TCF3/TP53/SS18L1/PER2/ITGB7/SMAD1/PLAT/DDIT3/DDB2	2.49552272194132
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	26/1106	140/9376	1.57437354688711	PDE3B/HDAC4/KRAS/AKT2/GNB5/CALM2/MAP1LC3B/GNG2/CALM3/GNG8/AKT3/PIK3C3/NRF1/RPS6KB2/SMAD4/PRKAA1/RAF1/GNAI3/SMAD2/GNAI1/RPS6KB1/BECN1/SPHK1/PLAT/TFAM/ADCY2	2.50395738103834
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	35/1106	204/9376	1.45445519980144	PLCG2/PPP1CB/PDCD4/CTNNB1/DDX5/KRAS/BRAF/HIF1A/VAV1/AKT2/CDC42/VAV3/STAT3/SOS2/TGFB1/CDKN1A/PRKCA/CASP3/PIK3CA/AKT3/ELK1/FAS/PLCE1/MYC/ANK3/RPS6KB2/RAF1/PXN/WNT7A/SMAD2/CAMK2G/TP53/RPS6KB1/PDPK1/PTPN11	2.39985269135471
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1106	76/9376	1.7847149519368	PLCG2/KRAS/BRAF/AKT2/CALM2/SOS2/CDKN1A/CALM3/PRKCA/PIK3CA/AKT3/RB1/RAF1/CAMK2G/TP53/DDB2	2.51181527110496
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	26/1106	142/9376	1.55219927157884	PLCG2/IFNGR1/SOCS3/RELB/IRF9/NFKB2/STAT2/FOSL2/AKT2/PPP3R1/STAT1/JUND/RELA/TGFB1/NFKB1/NFATC1/ATP2A2/IFNAR1/IKBKB/PIK3CA/AKT3/SOCS1/IFNGR2/PPP3CA/CYLD/MAPK8	2.42468604761274
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/1106	157/9376	1.51189228412481	GPR132/HIF1A/CD47/SIRT1/ODC1/RAB5A/UQCRFS1/TGFB1/S1PR1/CPT1A/NFATC1/NR1H2/ATP2A2/CASP1/SLC16A1/CASP3/PTGER4/ARNT/ADAM17/SGK1/DUSP8/DUSP16/ANO9/CALR/CAMK2G/RAB14/SPHK1/PTPN11	2.36535836990983
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1106	158/9376	1.50232334561769	KRAS/BRAF/AKT2/SLC7A5/SOS2/LPIN1/EIF4E/RHEB/IKBKB/PRKCA/PIK3CA/AKT3/LAMTOR3/SGK1/RPS6KA3/CAB39/RPS6KB2/PRKAA1/RAF1/ATP6V1E2/WNT7A/SLC3A2/ULK1/DDIT4/RPS6KB1/PDPK1/STRADB/FNIP1	2.3286488355318
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1106	14/9376	3.02764143632136	ST3GAL1/B4GALT4/FUT8/B4GALT1/ST3GAL2	2.77639532286682
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1106	78/9376	1.73895303009227	PLCG2/SYNJ2/INPP4B/MTMR6/PIK3CA/PIK3C2B/PIK3C3/PLCE1/PIP4K2A/PI4KA/PIK3C2A/MTMR3/ITPKB/INPP5D/IP6K1/SACM1L	2.39651312389593
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/1106	66/9376	1.79823551975451	IFNGR1/STAT4/STAT1/IL4R/STAT3/RELA/TGFB1/NFKB1/NFATC1/IL21R/RORA/IFNGR2/SMAD2/STAT6	2.37978993406331
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	39/1106	238/9376	1.38915312960627	PLCG2/KRAS/ARF6/RASA3/AKT2/GNB5/CALM2/CDC42/RASGRP3/GNG2/SOS2/RAB5A/RELA/NFKB1/CALM3/RALGAPA1/GNG8/RASA4/RAP1A/IKBKB/PRKCA/PIK3CA/AKT3/RAP1B/ELK1/PLCE1/FLT1/EXOC2/RASA2/RALGDS/RAF1/ETS1/RASGRF2/ABL2/FLT3LG/PTPN11/RASA4B/RALGAPA2/MAPK8	2.22379052771932
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1106	60/9376	1.83676913803496	PLCG2/KRAS/AKT2/PPP3R1/CDC42/SH2D2A/PRKCA/PIK3CA/AKT3/RAF1/PXN/PPP3CA/SPHK1	2.37780910778383
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	22/1106	119/9376	1.567249684684	SOCS3/BCL3/BIRC2/AKT2/IRF1/DNM1L/BIRC3/RELA/NFKB1/RIPK1/TRAF1/IKBKB/CASP3/PIK3CA/AKT3/RPS6KA5/FAS/ADAM17/FRMD8/TRAF3/CYLD/MAPK8	2.27731474915182
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1106	42/9376	2.01842762421424	MAP1LC3B/PRNP/VDAC2/PCBP2/VDAC3/LPCAT3/ATG5/SLC3A2/TP53/ACSL3	2.41897491441271
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/1106	55/9376	1.84961367746178	UGCG/KDSR/DEGS1/CERS2/GLA/SMPD1/CERK/DEGS2/CERS5/CERS6/SMPD4/SPHK1	2.3109046843739
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1106	300/9376	1.32812537673297	RELB/KRAS/BRAF/MAPK8IP1/NFKB2/AKT2/PPP3R1/JUND/CDC42/RASGRP3/MKNK2/SOS2/ELK4/RELA/TGFB1/NFKB1/NFATC1/RAP1A/IKBKB/PRKCA/CASP3/AKT3/MAP3K12/LAMTOR3/RAP1B/RPS6KA5/ELK1/FAS/IRAK1/RPS6KA3/MYC/DUSP8/DUSP16/FLT1/IRAK4/RASA2/MAP3K3/RAF1/MAP3K2/RASGRF2/TP53/PPP3CA/PPM1A/FLT3LG/DDIT3/MAPK8/AREG	2.11233915843473
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1106	75/9376	1.69547920433996	CYCS/BBC3/CDKN1A/CCNG1/CCND2/CASP3/COP1/FAS/RCHY1/TNFRSF10B/TP53/MDM4/ATR/CCND3/DDB2	2.21136486468171
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	30/1106	178/9376	1.42877461039885	CTNNB1/SENP2/SIRT1/PPP3R1/CUL1/INVS/NFATC1/CSNK1E/TBL1X/CCND2/PRKCA/TLE3/MYC/CCDC88C/CSNK1A1/SKP1/SMAD4/PSEN1/WNT7A/CAMK2G/TP53/PPP3CA/RYK/CTBP1/FRAT1/CHD8/FRAT2/MAPK8/TLE4/CCND3	2.11204324554673
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1106	32/9376	2.11934900542495	GABARAP/ATG13/PIK3C3/PPP2CA/ATG12/ATG5/ATG4B/BECN1	2.31944745758797
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	25/1106	144/9376	1.47177014265622	CTNNB1/TRA2A/SIRT1/AKT2/FASN/LPIN1/RELA/NFKB1/RIPK1/CPT1A/ACACA/IKBKB/FOXO1/CASP3/AKT3/ALDH7A1/FAS/IRAK1/IRAK4/TRAF3/PRKAA1/ALDH9A1/NOX4/ADIPOR2/MAPK8	2.08628793663389
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	21/1106	117/9376	1.52158390133074	EPC2/BAZ1A/SS18/PHF10/MORF4L1/MORF4L2/GATAD2A/ING3/HDAC1/BCL7B/BRD7/INO80D/INO80B/TRRAP/EPC1/SMARCA2/ACTR6/CHRAC1/SS18L1/SMARCC1/ARID2	2.07608683355446
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1106	71/9376	1.67159921554644	LDHA/KRAS/HIF1A/AKT2/SLC7A5/PIK3CA/AKT3/GLS/MYC/TIGAR/RAF1/TP53/PDK1/HK1	2.07726360822318
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/1106	98/9376	1.55707273867956	PLCG2/ARPC1B/ARF6/VAV1/AKT2/CDC42/VAV3/CFL2/DNM2/PRKCA/PIK3CA/AKT3/RPS6KB2/RAF1/RPS6KB1/SPHK1/ACTR3C/INPP5D	2.02725418991747
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	23/1106	133/9376	1.46601585337666	PLCG2/IFNGR1/KRAS/BRAF/HLA-C/VAV1/PPP3R1/VAV3/SOS2/NFATC1/IFNAR1/PRKCA/CASP3/PIK3CA/HLA-B/FAS/IFNGR2/ULBP2/RAF1/MICA/TNFRSF10B/PPP3CA/PTPN11	1.97938594459978
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	19/1106	106/9376	1.51953324917261	CTNNB1/KRAS/BRAF/AKT2/SOS2/RELA/NFKB1/CDKN1A/IKBKB/FOXO1/PIK3CA/AKT3/RB1/ZEB1/RAF1/TP53/PDPK1/PLAT/SLC19A1	1.96714720120631
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1106	34/9376	1.99468141687055	POLR3A/POLR2K/POLR3E/POLR2J3/POLR2C/POLR2M/POLR2L/POLR2B	2.12478004139167
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/1106	149/9376	1.42238188283554	NDUFA13/NDUFB8/NDUFV2/GNB5/NDUFA7/NDUFC1/GNG2/NDUFC2/GNG8/NDUFA3/NDUFA11/MT-ND4L/NDUFB1/PRKCA/NDUFA1/NDUFV3/NDUFB3/GNAI3/GNAI1/NDUFB9/NDUFA5/NDUFB6/NDUFB5/MAPK8/ADCY2	1.90054694989256
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	13/1106	67/9376	1.64486788480743	PPP1CB/KRAS/BRAF/PPP3R1/CALM2/CALM3/RAP1A/PRKCA/RAP1B/RPS6KA3/RAF1/CAMK2G/PPP3CA	1.93716708941949
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/1106	181/9376	1.35825682115632	IFNGR1/AKT2/PPP3R1/STAT1/CYCS/CALM2/BCL10/MALT1/RAB5A/RELA/TGFB1/NFKB1/CALM3/RIPK2/CASP3/AKT3/PIK3C3/IRAK1/LAMP2/IRAK4/IFNGR2/HSPA9/RAF1/CAMK2G/PPP3CA/SPHK1/CEBPG/TLR1/MAPK8	1.77978825137
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/1106	138/9376	1.41289933694997	PPP1CB/PPP3R1/CALM2/PPP2R5C/CUL1/CALM3/YWHAE/ANAPC16/YWHAQ/STAG3/SPDYA/RPS6KA3/PPP2R1B/CDC27/SKP1/PPP2CA/YWHAG/CAMK2G/PPP3CA/REC8/ANAPC10/CDC26/ADCY2	1.78692035773911
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1106	62/9376	1.64078632678061	DTX3L/NOTCH1/MFNG/HDAC1/TLE3/ADAM17/PSEN1/ATXN1/MAML2/CTBP1/TLE4/MAML1	1.85119177061406
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1106	69/9376	1.59719055481301	PLCG2/KRAS/VAV1/AKT2/VAV3/SOS2/PRKCA/PIK3CA/AKT3/RAF1/PDPK1/INPP5D/MAPK8	1.82071959247984
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/1106	83/9376	1.53205952199394	IRF7/POLR3A/IFI16/RELA/NFKB1/RIPK1/G3BP1/POLR2K/ADAR/CASP1/IKBKB/POLR3E/CASP3/POLR2L/NFKBIB	1.78045804547565
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1106	63/9376	1.61474209937139	KMT2E/EZH2/DLST/ALDH7A1/CAMKMT/SMYD3/PHYKPL/ALDH9A1/SETDB1/GCDH/SETD1B/NSD1	1.79031263252334
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/1106	133/9376	1.40227603366463	PPP1CB/AKT2/GNB5/CALM2/PPP2R3C/GNG2/PPP2R5C/CALM3/GNG8/GNAS/PPP2R2A/PRKCA/AKT3/PPP2R2D/PPP2R1B/PPP2CA/GNAI3/CAMK2G/PPP3CA/GNAI1/KIF5C/MAPK8	1.70865330249084
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1106	37/9376	1.83295049117834	CTNNB1/KRAS/BRAF/CDKN1A/MYC/TFG/TP53/DDB2	1.85643740292466
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1106	105/9376	1.45326788943425	PLCG2/RELB/BIRC2/NFKB2/BCL10/MALT1/BIRC3/RELA/NFKB1/RIPK1/TRAF1/IKBKB/PRKCQ/IRAK1/IRAK4/TRAF3/TRIM25/CYLD	1.708034975889
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1106	99/9376	1.4557144683727	KRAS/BRAF/AKT2/NOTCH1/SOS2/CDKN1A/GNAS/PIK3CA/AKT3/RB1/RPS6KB2/RAF1/TP53/RPS6KB1/NCOA3/MAPK8/ADCY2	1.66692892644095
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/1106	122/9376	1.38973705273768	PLCG2/SOCS3/KRAS/AKT2/STAT1/STAT3/SOS2/GHRL/IRS2/GNAS/STAT5B/PRKCA/PIK3CA/AKT3/SOCS1/RAF1/GNAI3/GNAI1/MAPK8/ADCY2	1.58451848953832
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1106	73/9376	1.50967326413832	MX1/ELL2/FURIN/MX2/RANBP2/CPSF6/NUP153/PDCD6IP/TNPO3/TRIM5/VPS4A/AFF4/SERINC5	1.59864568193658
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1106	80/9376	1.48354430379747	PLCG2/KRAS/BRAF/AKT2/STAT3/SOS2/EIF4E/PRKCA/PIK3CA/AKT3/RPS6KB2/RAF1/BCL2L11/RPS6KB1	1.58834066342936
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1106	116/9376	1.38853900355428	PGK1/ALDOA/DLST/PRPS2/PRPS1/OGDH/CS/GLUD1/PSPH/CPS1/ACSS2/ACO1/ACO2/IDH3A/SDHB/FH/SDHD/HK1/MDH1	1.53981508604613
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1106	33/9376	1.79823551975451	DLST/OGDH/CS/ACO1/ACO2/IDH3A/BCKDHB	1.67979116014141
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1106	33/9376	1.79823551975451	SEC22B/VTI1A/BET1L/STX5/VAMP7/STX11/STX16	1.67979116014141
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1106	47/9376	1.62333115309145	LDHA/ACACA/ALDH7A1/GLO1/ALDH9A1/ACSS2/FH/ACYP2/MDH1	1.56660916205684
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1106	75/9376	1.46941531042797	BIRC2/AKT2/CYCS/BBC3/BIRC3/CDKN1A/CASP3/PIK3CA/AKT3/FAS/MSH6/TP53/PDPK1	1.49256587105177
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	23/1106	148/9376	1.31743316553443	CTNNB1/KRAS/BRAF/NFKB2/AKT2/NOTCH1/SOS2/CDKN1A/PIK3CA/AKT3/RB1/MYC/CSNK1A1/RPS6KB2/RAF1/WNT7A/TP53/RPS6KB1/NCOA3/FRAT1/NCOA1/FRAT2/DDB2	1.42344211723834
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1106	41/9376	1.6541260530146	KRAS/BRAF/CDKN1A/RB1/RPS6KA5/MYC/RAF1/TP53	1.53499392493021
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1106	150/9376	1.29986738999397	CTNNB1/KRAS/BRAF/AKT2/SOS2/TGFB1/CDKN1A/PIK3CA/AKT3/RB1/MYC/ABCB1/CSNK1A1/RPS6KB2/SMAD4/RAF1/WNT7A/SMAD2/TP53/RPS6KB1/FRAT1/FRAT2/DDB2	1.353875068861
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1106	56/9376	1.51382071816068	CSNK1D/CUL3/CUL1/CSNK1E/CSNK1G2/CCND2/MOSMO/CSNK1A1/CSNK1G3/SMURF1	1.41028899200216
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/1106	78/9376	1.41289933694997	CALM2/IRF1/CFL2/RELA/NFKB1/CALM3/CASP1/CASP3/IRAK1/IRAK4/GNAI3/GNAI1/MAPK8	1.33908197077827
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1106	23/9376	1.8429121786304	ATP1A1/GLS/GLUD1/SLC9A3/MDH1	1.48006649171845
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/1106	130/9376	1.3042147725692	KRAS/AKT2/GNB5/GNG2/SOS2/RELA/TGFB1/NFKB1/GNG8/GNAS/INSL3/PRKCA/PIK3CA/AKT3/RAF1/GNAI3/SMAD2/GNAI1/MAPK8/ADCY2	1.27727813540608
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	21/1106	138/9376	1.29003852504128	ARPC1B/ARF6/VAV1/ELMO2/AKT2/CDC42/VAV3/RELA/NFKB1/NFATC1/CASP1/IKBKB/PIK3CA/AKT3/IRAK1/RPS6KA3/IRAK4/PXN/ACTR3C/MAPK8/ARHGEF7	1.25521089172318
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	23/1106	154/9376	1.26610460064348	PPP1CB/AKT2/CALM2/CREM/PPP2R3C/PPP2R5C/CALM3/ATP1A1/ATP2A2/GNAS/PPP2R2A/TPM4/PRKCA/AKT3/PPP2R2D/RPS6KA5/PPP2R1B/PPP2CA/GNAI3/CAMK2G/GNAI1/ATP2B4/ADCY2	1.217616799531
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1106	37/9376	1.60383167978105	UAP1/UGP2/NANS/UXS1/GFPT1/GALT/HK1	1.34578912827168
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	29/1106	200/9376	1.22922242314647	ARPC1B/NCK2/ARF6/CYTH1/CYCS/CDC42/RELA/NFKB1/RIPK1/TUBB2A/RAB1A/CASP1/IKBKB/CASP3/FAS/TUBB4B/TMED10/IRAK1/SEC24C/IRAK4/SEC24B/TMBIM6/CYTH2/TNFRSF10B/NFKBIB/ACTR3C/PTPN11/MAPK8/CLDN1	1.19827318703738
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/1106	109/9376	1.32216268228346	IRF7/IRF9/STAT2/AKT2/STAT1/RELA/NFKB1/RIPK1/IFNAR1/IKBKB/PIK3CA/AKT3/IRAK1/IRAK4/TRAF3/TLR1/MAPK8	1.23716990474135
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/1106	44/9376	1.54134473121815	GTF2H2/TAF4B/GTF2B/GTF2H2C/TAF9/TAF11/CCNH/TAF2	1.31620438802835
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1106	24/9376	1.76612417118746	NDST2/HS6ST1/B3GALT6/HS3ST3B1/XYLT2	1.37424125882205
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/1106	110/9376	1.31014302153543	PDE3B/KRAS/BRAF/AKT2/PIK3CA/AKT3/ANAPC16/SPDYA/RPS6KA3/CDC27/RAF1/GNAI3/GNAI1/ANAPC10/CDC26/MAPK8/ADCY2	1.19652741917445
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1106	31/9376	1.64078632678061	SRP54/SEC61G/SPCS3/IMMP2L/SEC62/TMEM208	1.30681730582624
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1106	38/9376	1.5616255829447	UAP1/UGP2/UXS1/GNPDA1/GFPT1/GALT/HK1	1.26859265571536
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1106	18/9376	1.88386578259996	FASN/ACACA/ACSF3/ACSL3	1.37259211674757
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/1106	149/9376	1.25169605689528	PLCG2/KRAS/ARF6/AGPAT5/CYTH1/AKT2/SOS2/DNM2/LPAR6/RHEB/GNAS/PRKCA/PIK3CA/AKT3/RALGDS/RAF1/DGKD/CYTH2/SPHK1/PTPN11/DGKE/ADCY2	1.13253004608286
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1106	39/9376	1.52158390133074	MTHFD2/MAT2A/MTHFS/MTHFD2L/ALDH7A1/MTHFD1L/AHCY	1.1936122009794
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1106	47/9376	1.44296102497018	SOCS3/IRS2/IKBKB/PIK3CA/SOCS1/SOCS4/MAPK8/HK1	1.11328753056974
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1106	48/9376	1.41289933694997	LDLR/IST1/DPP4/PDCD6IP/LAMP2/VPS4A/CHMP1B/CLDN1	1.04877175432405
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/1106	93/9376	1.27616714305159	KRAS/CALM2/CDC42/SOS2/CALM3/GNAS/PRKCA/ELK1/MAP3K3/RAF1/MAP3K2/CAMK2G/MAPK8/ADCY2	0.978767980009067
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1106	20/9376	1.69547920433996	CYP51A1/DHCR7/EBP/SC5D	1.13858245371034
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	48/1106	362/9376	1.12407461061213	KRAS/JAK3/AKT2/GNB5/IL2RB/IL4R/PPP2R3C/GNG2/SOS2/PPP2R5C/EIF4E/RELA/LPAR6/RHEB/NFKB1/CDKN1A/YWHAE/GNG8/PPP2R2A/IFNAR1/IKBKB/CCND2/PRKCA/PIK3CA/AKT3/PPP2R2D/YWHAQ/SGK1/MYC/FLT1/PPP2R1B/RPS6KB2/PPP2CA/PRKAA1/RAF1/YWHAG/BCL2L11/TP53/THEM4/ITGA6/DDIT4/RPS6KB1/PDPK1/CRTC2/ITGB7/FLT3LG/AREG/CCND3	0.880417925327977
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1106	28/9376	1.51382071816068	ELOVL5/PPT1/ACOT2/THEM4/HACD4	0.995730299188052
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1106	51/9376	1.32978761124703	PLCG2/SEC61G/SLC12A2/GNAS/PRKCA/ERO1A/PDIA4/ATP6V1E2	0.863585718674228
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1106	144/9376	1.17741611412497	CTNNB1/KRAS/SKIL/JAK3/AKT2/STAT3/KAT6A/PCGF5/JARID2/PIK3CA/AKT3/MYC/SMAD4/RAF1/TCF3/WNT7A/SETDB1/SMAD2/SMAD1/ACVR1B	0.784579321996477
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1106	59/9376	1.29316210500506	PDE3B/AKT2/IRS2/GNAS/PIK3CA/AKT3/GNAI3/GNAI1/ADCY2	0.826049811438464
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1106	15/9376	1.69547920433996	ST3GAL1/ST3GAL5/ST3GAL2	0.985777956437505
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1106	52/9376	1.3042147725692	LDLR/VDAC1/VDAC2/VAPA/VAPB/VDAC3/LRPAP1/STARD3	0.804435607104402
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/1106	75/9376	1.24335141651597	PGK1/MAT2A/ALDOA/PRPS2/PRPS1/CS/PSPH/CPS1/ACO1/ACO2/IDH3A	0.773766877421823
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1106	60/9376	1.27160940325497	KRAS/BRAF/GNAS/PRKCA/PPP2R1B/PPP2CA/RAF1/GNAI3/GNAI1	0.771820187269409
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/1106	91/9376	1.21105657452855	PDE3B/PDE4D/PDE4B/GNB5/GNG2/GNG8/GNAS/PRKCA/GRK5/GRK6/GNAI3/GNAI1/ADCY2	0.739842156989787
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1106	30/9376	1.41289933694997	ABCC1/RELA/NFKB1/IKBKB/SLC19A1	0.828328055909066
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1106	45/9376	1.31870604781997	ABCC1/TAP1/ABCD3/ABCB1/ABCB7/TAP2/ABCA5	0.783687489452955
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1106	23/9376	1.47432974290432	POLD4/POLD2/MSH6/RFC1	0.832873905842495
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1106	38/9376	1.3385362139526	KRAS/ATP1A1/PRKCA/PIK3CA/SGK1/PDPK1	0.764681253411207
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1106	16/9376	1.58951175406872	ST3GAL1/GLA/ST3GAL2	0.863028191717906
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/1106	116/9376	1.16929600299308	PLCG2/CTNNB1/ITK/VAV1/TXK/CDC42/VAV3/RAP1A/PRKCA/PIK3CA/RAP1B/PXN/GNAI3/GNAI1/PTPN11/CLDN1	0.670935316741334
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1106	69/9376	1.22860811908693	PPP1CB/SIRT1/PPP3R1/CALM2/CALM3/GNAS/HDAC1/PRKCA/CAMK2G/PPP3CA	0.696982358590495
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1106	31/9376	1.36732193898384	CS/ACSS2/ACO1/ACO2/MDH1	0.749115027290652
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/1106	78/9376	1.19553020818844	IFNGR1/STAT1/EEF1A1/RELA/TGFB1/NFKB1/ELK1/IRAK1/IRAK4/IFNGR2/NFKBIB	0.634127868699826
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1106	32/9376	1.3245931283906	UGP2/GLA/B4GALT1/GALT/HK1	0.672602291820743
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1106	17/9376	1.49601106265291	CA5B/GLUD1/CPS1	0.748534025901696
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1106	71/9376	1.19399943967603	PLCG2/CDC42/RELA/NFKB1/IKBKB/CASP3/ADAM17/ATP6V1E2/PTPN11/MAPK8	0.600042356700517
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	32/1106	250/9376	1.08510669077758	BLOC1S2/IDS/AP3M2/PPT1/LAPTM4A/BLOC1S6/PLEKHM1/AP1G1/AP1G2/CLN8/GLA/LAMTOR3/M6PR/HGSNAT/LAMP2/SMPD1/VPS26A/AP5M1/LITAF/MFSD8/ATP6V1E2/CLN5/ENTPD4/VAMP7/VPS26B/VPS13C/OSBP/DMXL1/NCOA7/AP3S1/GGA2/ABCA5	0.498774133828017
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	29/1106	226/9376	1.08780745411192	PPP1CB/PDE3B/BRAF/PDE4D/VAV1/PDE4B/AKT2/CALM2/VAV3/GHRL/RELA/NFKB1/CALM3/NFATC1/ATP1A1/ATP2A2/GNAS/RAP1A/PIK3CA/AKT3/RAP1B/PLCE1/RAF1/GNAI3/CAMK2G/GNAI1/ATP2B4/MAPK8/ADCY2	0.488636050206474
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/1106	170/9376	1.0970747792788	RAPGEF6/ARPC1B/RAP2C/YBX3/CDC42/PPP2R2A/WHAMM/RAP1A/PPP2R2D/HSPA4/PPP2R1B/PARD6A/PPP2CA/NF2/PRKAA1/RAB8B/NEDD4/ACTR3C/PATJ/ARHGAP17/MAPK8/CLDN1	0.467095662145092
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1106	97/9376	1.13614585857833	GNB5/CALM2/GNG2/CALM3/GNG8/GNAS/PRKCA/RPS6KA5/GNAI3/CAMK2G/GNAI1/PER2/ADCY2	0.492890175561817
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1106	89/9376	1.14301968831908	KRAS/CSNK1D/SOS2/TUBB2A/GNAS/PRKCA/TUBB4B/RAF1/MAP3K2/GNAI3/GNAI1/ADCY2	0.495750949543372
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1106	89/9376	1.14301968831908	GNB5/GNG2/GABARAP/GNG8/SLC38A2/PRKCA/GLS/GNAI3/GNAI1/SLC38A1/PLCL1/ADCY2	0.495750949543372
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1106	57/9376	1.18980996795787	ELOVL5/FASN/PPT1/CPT1A/ACACA/ACSF3/HACD4/ACSL3	0.52563253003369
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1106	73/9376	1.16128712626025	KRAS/BRAF/AKT2/CDKN1A/PIK3CA/AKT3/RB1/RAF1/TP53/DDB2	0.505894631110039
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/1106	212/9376	1.07966836125422	RAPGEF6/CTNNB1/KRAS/BRAF/VAV1/AKT2/CALM2/CDC42/VAV3/RASGRP3/CALM3/GNAS/RAP1A/PRKCA/PIK3CA/AKT3/RAP1B/PLCE1/FLT1/PRKD3/PARD6A/RALGDS/SIPA1L1/RAF1/GNAI3/GNAI1/ADCY2	0.42906364819393
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1106	50/9376	1.18683544303797	ODC1/OAT/AMD1/P4HA1/ALDH7A1/LAP3/ALDH9A1	0.484403206975983
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1106	99/9376	1.11319341699089	PLCG2/PPP1CB/CALM2/CALM3/PRKCH/GNAS/PRKCA/PIK3CA/PTGER4/PRKCQ/CAMK2G/MAPK8/ADCY2	0.414042989985753
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1106	19/9376	1.3385362139526	DLST/OGDH/BCKDHB	0.540162045952307
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1106	59/9376	1.14947742667116	CMPK2/CTPS1/NME2/CMPK1/DPYD/NT5C2/UPP1/ENTPD4	0.421186087860469
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1106	217/9376	1.05479121007325	KRAS/KPNA5/AKT2/STAT3/SOS2/KPNA1/RELA/NFKB1/GNAS/STAT5B/AIPL1/PRKCA/PIK3CA/AKT3/RB1/ARNT/RPS6KA3/MYC/KPNA4/RPS6KB2/RAF1/GNAI3/GNAI1/AHR/RPS6KB1/ADCY2/CCND3	0.298625696943678
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1106	44/9376	1.15600854841361	POLB/POLD4/POLD2/TDP1/RFC1/TDG	0.379313077509537
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1106	85/9376	1.0970747792788	CMPK2/CTPS1/NME2/CMPK1/ADSL/HPRT1/NT5C2/UPP1/ENTPD4/AK6/AK3	0.328772202808974
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1106	36/9376	1.17741611412497	ST3GAL1/GCNT4/ST6GALNAC1/ST3GAL2/GALNT11	0.390015010480953
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1106	12/9376	1.41289933694997	COQ2/GGCX	0.523376902866621
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1106	20/9376	1.27160940325497	UAP1/UGP2/NANS	0.444657006103206
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1106	69/9376	1.10574730717824	PDE3B/PPP3R1/CALM2/CALM3/GNAS/PTGER4/GNAI3/PPP3CA/GNAI1	0.322403280627381
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1106	61/9376	1.11178964219014	HMOX2/ATP1A1/MT2A/MT1X/TRPM7/SLC9A3/CLCN2/ATP2B4	0.320321065846835
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/1106	203/9376	1.04401428838668	PPP1CB/CTNNB1/BRAF/BIRC2/VAV1/AKT2/CDC42/VAV3/SOS2/BIRC3/RAP1A/CCND2/PRKCA/PIK3CA/AKT3/RAP1B/ELK1/FLT1/RAF1/PXN/ITGA6/PDPK1/ITGB7/MAPK8/CCND3	0.231844316416212
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1106	37/9376	1.14559405698646	ADSL/GLS/GLUD1/GFPT1/CPS1	0.324492578965708
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1106	21/9376	1.21105657452855	CHST12/B3GALT6/XYLT2	0.354076483620989
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1106	38/9376	1.1154468449605	SIRT1/SIRT2/NT5C2/NNT/NMNAT1	0.260769851107055
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1106	30/9376	1.13031946955998	PIGA/PIGX/PIGB/PIGK	0.261437263777431
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/1106	115/9376	1.03203082003302	BRAF/PDE4D/PDE4B/JUND/CDKN1A/GNAS/PRKCA/SGK1/RAF1/GNAI3/OXSR1/GNAI1/BGLAP/ADCY2	0.126385858357599
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1106	166/9376	1.02137301466263	PPP1CB/PDE3B/VDAC1/AKT2/PPP3R1/CALM2/CALM3/IRS2/NFATC1/ATP1A1/ATP2A2/VDAC2/AKT3/VDAC3/RAF1/GNAI3/PPP3CA/GNAI1/ATP2B4/ADCY2	0.101601579494956
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1106	31/9376	1.09385755118707	ALDOA/PRPS2/PRPS1/DERA	0.191412748755067
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/1106	48/9376	1.05967450271248	HMGCS1/AUH/ALDH7A1/ACSF3/ALDH9A1/BCKDHB	0.151574311938805
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1106	65/9376	1.04337181805536	AGPAT5/LPIN1/GLA/ALDH7A1/ABHD16A/DGKD/ALDH9A1/DGKE	0.128314752070678
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1106	23/9376	1.10574730717824	GLS/GLUD1/CPS1	0.185681319966543
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1106	23/9376	1.10574730717824	POMGNT1/B4GALT1/B3GALNT2	0.185681319966543
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1106	23/9376	1.10574730717824	IDI1/HMGCS1/HMGCR	0.185681319966543
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1106	32/9376	1.05967450271248	LDHA/ACACA/ACSS2/BCKDHB	0.123653903231669
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1106	101/9376	1.00721536891483	CTNNB1/KRAS/CALM2/CALM3/GNAS/PRKCA/RAF1/WNT7A/GNAI3/CAMK2G/GNAI1/ADCY2	0.0266607716835099
NA	NA	hsa04517	IgSF CAM signaling	35/1106	299/9376	0.992337326954828	PLCG2/RAPGEF6/ARPC1B/CTNNB1/NCK2/ARF6/MBP/CD2/VAV1/AKT2/CDC42/VAV3/TUBB2A/RAP1A/FOXO1/PRKCA/PIK3CA/AKT3/RAP1B/PRKCQ/TUBB4B/ANK3/ICAM3/MPZ/CD28/PARD6A/CXADR/PXN/SLAMF1/PDPK1/ACTR3C/NECTIN1/PTPN11/INPP5D/MAPK8	-0.0492442093115007
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1106	76/9376	1.00390216046445	CALM2/CALM3/ATP1A1/GNAS/PRKCA/GNAI3/CAMK2G/GNAI1/ADCY2	0.0124905307598915
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/1106	154/9376	0.99086447006881	CMPK2/MTHFD2/GCH1/MAT2A/CTPS1/NME2/MTHFD2L/CMPK1/COQ2/ADSL/UGP2/MTHFD1L/GGCX/AK6/AK3/RDH11/NMNAT1/MOCS2	-0.0418015122246545
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/1106	154/9376	0.99086447006881	PPP1CB/KRAS/PPP3R1/CALM2/CDKN1A/CALM3/NFATC1/GNAS/PRKCA/ELK1/PRKAA1/RAF1/GNAI3/CAMK2G/PPP3CA/GNAI1/KCNJ14/ADCY2	-0.0418015122246545
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1106	104/9376	0.978161079426902	GPCPD1/AGPAT5/LPIN1/CHKB/ETNK1/CDS2/CHKA/LPCAT3/DGKD/CHPT1/DGKE/PGS1	-0.0818976752195971
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/1106	78/9376	0.978161079426902	ARPC1B/CTNNB1/ELMO2/CDC42/ARHGEF26/DNM2/PIK3CA/PXN/ACTR3C	-0.0708262333786148
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1106	139/9376	0.975815369404296	FKBP5/KRAS/AKT2/CALM2/SOS2/CALM3/GNAS/PIK3CA/AKT3/FKBP4/RAF1/GNAI3/GNAI1/NCOA3/NCOA1/ADCY2	-0.105048978444158
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1106	43/9376	0.985743723453467	CPT1A/ALDH7A1/ALDH9A1/GCDH/ACSL3	-0.0342641650277832
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/1106	70/9376	0.968845259622837	HLA-C/CD55/CYCS/CASP3/HLA-B/CD28/CXADR/ABL2	-0.0956757949343258
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1106	35/9376	0.968845259622837	PFKFB3/ALDOA/TIGAR/HK1	-0.0675261391751821
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1106	44/9376	0.963340457011343	DCTN6/RAB5A/GNAS/DCTN4/RAB11A	-0.08913257774987
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1106	53/9376	0.959705210003753	DNM2/ATP1A1/GNAS/PRKCA/RAB11A/ATP2B4	-0.107577001823674
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/1106	115/9376	0.958314332887806	KRAS/AKT2/GNB5/GNG2/GNG8/PRKCA/PIK3CA/AKT3/GNAI3/CAMK2G/GNAI1/KCNJ14/ADCY2	-0.164481546640154
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1106	17/9376	0.997340708435273	SEPHS2/SEPHS1	-0.00401315690489855
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1106	17/9376	0.997340708435273	PCDH11X/LAMP2	-0.00401315690489855
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1106	116/9376	0.950053002431876	PPP3R1/GNB5/GNG2/GNG8/GNAS/SLC38A2/PRKCA/GLS/GNAI3/PPP3CA/GNAI1/SLC38A1/ADCY2	-0.197944452563465
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1106	54/9376	0.94193289129998	LDHA/MAT2A/AMD1/APIP/AHCY/MDH1	-0.156488698842436
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1106	27/9376	0.94193289129998	ELOVL5/ACOT2/HACD4	-0.110494319383706
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1106	82/9376	0.930445904820712	TAP1/HLA-C/B2M/HLA-B/TAPBP/HSPA4/CALR/PDIA3/TAP2	-0.231333614898808
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/1106	83/9376	0.919235713196366	SOD2/MPV17L/ABCD3/SOD1/PEX2/PEX6/PEX3/PEX19/ACSL3	-0.270265671945384
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1106	28/9376	0.908292430896409	B4GALT4/FUT6/B4GALT1	-0.177719585827933
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1106	65/9376	0.912950340798442	KRAS/AKT2/PRKCA/PIK3CA/AKT3/RAF1/KCNN1	-0.257534868011001
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	14/1106	128/9376	0.927215189873418	PDE3B/PDE4D/PDE4B/NME2/ADSL/HPRT1/PRPS2/PRPS1/NT5C2/ENTPD4/AK6/PDE9A/AK3/ADCY2	-0.303202148637889
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/1106	155/9376	0.929778918509012	CTNNB1/BRAF/LDLR/CDKN1A/GNAS/RAP1A/AIPL1/RB1/RAP1B/ARNT/WNT7A/GNAI3/CAMK2G/FH/GNAI1/AHR/ADCY2	-0.322370133311718
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/1106	93/9376	0.911547959322561	YES1/CTNNB1/CDC42/RAP1A/PTPN1/RAP1B/SMAD4/NECTIN1/ACP1/SMURF1	-0.313484161167447
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1106	38/9376	0.892357475968402	TAP1/JAK3/ICOS/TAP2	-0.243141551197097
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1106	19/9376	0.892357475968402	IDS/HGSNAT	-0.171752396393607
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1106	29/9376	0.876972002244809	CSNK1E/MOB1A/NF2	-0.242648315407796
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1106	48/9376	0.883062085593731	AKT2/ATP1A1/PIK3CA/AKT3/HK1	-0.297024409253819
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1106	94/9376	0.901850640606364	JUND/TRAF4/RELA/NFKB1/IKBKB/CASP3/ELAVL1/TRAF3/SRSF1/MAPK8	-0.34973658176009
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	20/1106	184/9376	0.921456089315198	PLCG2/NCK2/KRAS/SSH2/PPP3R1/CDC42/CFL2/SEMA4D/PRKCA/PIK3CA/PARD6A/RAF1/GNAI3/CAMK2G/SSH1/PPP3CA/GNAI1/RYK/PDPK1/PTPN11	-0.393483813243554
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/1106	67/9376	0.885698091819384	LDHA/PGK1/ALDOA/ALDH7A1/ALDH9A1/ACSS2/HK1	-0.343360089720485
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1106	39/9376	0.869476515046135	HLA-C/HLA-B/FAS/CD28	-0.298694848053783
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1106	49/9376	0.865040410377533	RELA/NFKB1/GNAS/GNAI3/GNAI1	-0.34637077995165
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/1106	142/9376	0.895499579757023	CTNNB1/NFE2L2/AKT2/CALM2/RELA/SUMO1/NFKB1/CALM3/IKBKB/PIK3CA/AKT3/PRKAA1/TP53/PLAT/MAPK8	-0.458857379888155
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1106	31/9376	0.820393163390305	ALDH7A1/DPYD/ALDH9A1	-0.366289529780518
NA	NA	hsa04981	Folate transport and metabolism	3/1106	31/9376	0.820393163390305	ABCC1/MTHFS/SLC19A1	-0.366289529780518
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1106	41/9376	0.827063026507299	UIMC1/POLD4/POLD2/ABRAXAS1	-0.405819646662488
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/1106	98/9376	0.865040410377533	LDLR/CALM2/CALM3/ATP1A1/GNAS/PRKCA/PRKD3/CAMK2G/ATP2B4/ADCY2	-0.49113405581505
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1106	42/9376	0.807371049685697	DLST/ALDH7A1/ALDH9A1/GCDH	-0.457533346033757
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1106	22/9376	0.770672365609074	ALDH7A1/ALDH9A1	-0.393803431076086
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	19/1106	183/9376	0.880166800067194	SBDS/GNL3/HEATR1/GNL3L/NOP58/WDR43/NOB1/XRN2/GTPBP4/NMD3/UTP4/EMG1/AK6/LSG1/RIOK2/BMS1/REXO2/NXT1/POP5	-0.598665895597397
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1106	102/9376	0.831117257029394	SLC12A2/ATP1A1/ATP2A2/GNAS/RAP1A/PRKCA/RAP1B/RAB11A/ATP2B4/ADCY2	-0.627136764567672
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1106	12/9376	0.706449668474985	SLAMF1	-0.372094236052619
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1106	44/9376	0.770672365609074	HLA-C/HLA-B/FAS/CD28	-0.557578233009277
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1106	45/9376	0.753546313039984	HLA-C/HLA-B/FAS/CD28	-0.606021355795609
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1106	115/9376	0.810881358597374	KRAS/BRAF/GNB5/GNG2/GNG8/GNAS/PRKCA/CASP3/RAF1/GNAI3/GNAI1	-0.746216356635661
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1106	36/9376	0.706449668474985	PYGM/UGP2/HK1	-0.645313624363162
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1106	36/9376	0.706449668474985	POLD4/POLD2/RFC1	-0.645313624363162
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/1106	87/9376	0.779530668662052	UQCR11/UQCRFS1/ATP1A1/ATP2A2/COX6C/TPM4/COX7C/COX7A2L	-0.755498796249968
Organismal Systems	Immune system	hsa04611	Platelet activation	12/1106	126/9376	0.807371049685697	PLCG2/PPP1CB/AKT2/GNAS/RAP1A/PIK3CA/AKT3/RAP1B/GP1BA/GNAI3/GNAI1/ADCY2	-0.796061116086837
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/1106	155/9376	0.820393163390305	TAP1/HLA-C/SEC61G/RAB5A/SEC22B/TUBB2A/STX12/M6PR/HLA-B/TUBB4B/PIK3C3/LAMP2/ATP6V1E2/CALR/TAP2	-0.824536999889334
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1106	26/9376	0.652107386284602	ABCC1/SLC19A1	-0.649585801425324
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	33/1106	323/9376	0.866111667851684	PLCG2/PDCD4/HDAC4/ABCC1/KRAS/PIM1/SIRT1/NOTCH1/STAT3/SOS2/NFKB1/CDKN1A/IRS2/CCNG1/EZH2/IKBKB/HDAC1/CCND2/PRKCA/CASP3/PIK3CA/SOCS1/RPS6KA5/HNRNPK/ZEB1/GLS/MYC/ABCB1/RAF1/BCL2L11/TP53/DDIT4/MDM4	-0.895484719475946
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1106	49/9376	0.692032328302026	OGT/MFNG/B4GALT1/GALNT11	-0.790392168087645
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1106	90/9376	0.753546313039984	LDLR/SLC51A/ATP1A1/GNAS/ABCB1/HMGCR/SLC9A3/ADCY2	-0.859117729428121
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1106	15/9376	0.565159734779988	ACP1	-0.61634617591785
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1106	100/9376	0.762965641952984	CD2/CD55/IL4R/CD59/GP1BA/CD5/ITGA6/FLT3LG/IL11RA	-0.871447800968971
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1106	50/9376	0.678191681735986	ICOS/TGFB1/CD28/ITGB7	-0.834343735128202
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1106	28/9376	0.605528287264273	GCH1/MOCS2	-0.764444528335925
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1106	16/9376	0.529837251356239	MIF	-0.688304692781152
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/1106	103/9376	0.740743341701926	RAB5A/RELA/TGFB1/NFKB1/GNAS/SERPINB9/PRKCA/CASP3/PIK3CA	-0.967495265033968
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/1106	93/9376	0.729238367458049	CALM2/SLC12A2/CALM3/ATP1A1/GNAS/PRKCA/ATP2B4/ADCY2	-0.959610231755703
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1106	29/9376	0.584648001496539	CALM2/CALM3	-0.819199406452776
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/1106	52/9376	0.652107386284602	LDLR/GNAS/ACOT2/ADCY2	-0.919932991937864
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1106	63/9376	0.672809208071414	CTNNB1/CDKN1A/WNT7A/TP53/DDB2	-0.952877326335785
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1106	17/9376	0.498670354217636	GGT1	-0.756560339711493
NA	NA	hsa04518	Integrin signaling	14/1106	154/9376	0.770672365609074	CTNNB1/NCK2/AKT2/CDC42/TGFB1/CCND2/PIK3CA/AKT3/FLT1/ICAM3/PXN/ITGA6/ITGB7/CCND3	-1.04933616162918
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1106	54/9376	0.627955260866653	HLA-C/HLA-B/FAS/CD28	-1.00264673825805
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1106	195/9376	0.782528863541522	PLCG2/HDAC4/VDAC1/AKT2/RELA/NFKB1/VDAC2/CASP1/HDAC1/PRKCA/PIK3CA/AKT3/HAT1/VDAC3/GP1BA/RAF1/HDAC10/CLCN3	-1.12223648233782
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1106	31/9376	0.546928775593537	ALDH7A1/ALDH9A1	-0.923991808316103
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1106	18/9376	0.47096644564999	MAN2C1	-0.821558318571575
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1106	18/9376	0.47096644564999	MMADHC	-0.821558318571575
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/1106	254/9376	0.801013797325967	PLCG2/PHKG1/VDAC1/PPP3R1/CALM2/CYSLTR2/CALM3/NFATC1/STIM2/ATP2A2/VDAC2/GNAS/PRKCA/PLCE1/CYSLTR1/VDAC3/FLT1/CAMK2G/PPP3CA/SPHK1/ATP2B4/ITPKB/PHKA2/ADCY2	-1.17572359944669
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/1106	160/9376	0.741772151898734	HLA-C/CD2/ICOS/CD6/HLA-B/ICAM3/MPZ/CD28/SELL/CXADR/ITGA6/ITGB7/NECTIN1/CLDN1	-1.2047648311005
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1106	191/9376	0.754532630203649	PPP1CB/HDAC4/KRAS/BRAF/GNB5/CALM2/GNG2/SOS2/CALM3/GNG8/GNAS/HDAC1/HAT1/RAF1/GNAI3/GNAI1/HDAC10	-1.25337584095708
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/1106	232/9376	0.767350501964208	PPP1CB/ARPC1B/KRAS/BRAF/SSH2/VAV1/AKT2/CDC42/VAV3/CFL2/SOS2/PIK3CA/AKT3/PIP4K2A/RAF1/PXN/SSH1/ITGA6/ACTR3C/ITGB7/ARHGEF7	-1.31216500321499
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1106	21/9376	0.403685524842848	DPYD	-1.00039969362519
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/1106	59/9376	0.574738713335581	ODC1/LAP3/PRDX6/GGT1	-1.19826880645151
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/1106	134/9376	0.695905643572373	PPP1CB/BRAF/CALM2/CALM3/PRKCH/GNAS/PRKCA/PRKCQ/RAF1/ADM2/ADCY2	-1.29654687965072
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1106	37/9376	0.458237622794585	PRKCA/FAS	-1.20745224499324
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1106	23/9376	0.368582435726079	ATP6AP2	-1.10870385178536
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1106	86/9376	0.59144623407208	ATP1A1/GNAS/PRKCA/KCNN1/CAMK2G/ADCY2	-1.39187756138715
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/1106	75/9376	0.565159734779988	ATP1A1/GNAS/PRKCA/PDIA4/ADCY2	-1.38263010346801
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/1106	76/9376	0.557723422480251	CPT1A/HMGCS1/UBC/PDPK1/ACSL3	-1.41569503515158
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/1106	41/9376	0.41353151325365	ALDH7A1/PSPH	-1.37622643245884
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1106	27/9376	0.313977630433327	HMGCS1	-1.30541327963933
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1106	28/9376	0.302764143632136	ATP6V1E2	-1.35116947084392
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/1106	105/9376	0.565159734779988	TGFB1/ATP2A2/GNAS/TPM4/ITGA6/ITGB7/ADCY2	-1.63859474547747
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/1106	82/9376	0.516914391567062	NME2/CMPK1/HPRT1/DPYD/UPP1	-1.60671977424644
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/1106	99/9376	0.513781577072716	TGFB1/ATP2A2/TPM4/PRKAA1/ITGA6/ITGB7	-1.77850739881084
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/1106	63/9376	0.403685524842848	HPGD/LTA4H/GGT1	-1.73664588600982
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/1106	65/9376	0.391264431770761	LDLR/GNAS/ADCY2	-1.80093334833772
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/1106	194/9376	0.611770846926791	BICDL1/DCTN6/TUBD1/DYNLT3/CAPZA1/DYNLT1/TUBB2A/DCTN4/CAPZA2/TPM4/TUBE1/TUBB4B/KLC1/KIF5C	-1.99816253664131
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/1106	51/9376	0.332446902811758	PAFAH1B1/CHPT1	-1.7480623938802
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1106	36/9376	0.235483222824995	UGP2	-1.68064225920728
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1106	37/9376	0.229118811397292	MIF	-1.71810051964623
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/1106	54/9376	0.313977630433327	WDR48/ATR	-1.84880477767367
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/1106	86/9376	0.394297489381387	CTNNB1/ATP2A2/ITGA6/ITGB7	-2.06353191113322
NA	NA	hsa04081	Hormone signaling	15/1106	219/9376	0.580643563130125	GNB5/STAT3/GNG2/GHRL/IRS2/GNG8/GNAS/STAT5B/PIK3CA/SMAD4/GNAI3/GNAI1/SMAD1/ADIPOR2/ADCY2	-2.29635596801111
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/1106	89/9376	0.381006562773026	CD47/GP1BA/ITGA6/ITGB7	-2.14562475889172
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/1106	103/9376	0.411524078723292	ATP1A1/SLC38A2/DPP4/SLC3A2/SLC9A3	-2.19607732028669
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1106	46/9376	0.18429121786304	HMOX2	-2.0280734467572
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/1106	95/9376	0.356942990387361	TGFB1/FLT1/CD28/ATP6V1E2	-2.3036916057332
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/1106	50/9376	0.169547920433996	TGFB1	-2.15309067723239
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1106	100/9376	0.339095840867993	CCR7/IL2RB/TNFRSF10B/CXCR5	-2.42978900135901
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/1106	88/9376	0.289002137103403	CD55/CD59/PLAT	-2.45052408284726
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/1106	79/9376	0.214617620802527	DNM2/ATP6V1E2	-2.56350241142281
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1106	68/9376	0.124667588554409	RDH11	-2.64916937337724
NA	NA	hsa04382	Cornified envelope formation	11/1106	217/9376	0.429729752252065	UGCG/FURIN/KDSR/PPP2R3C/PPP2R5C/PPP2R2A/PPP2R2D/PPP2R1B/PPP2CA/ITGA6/CLDN1	-3.10811442113258
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/1106	298/9376	0.483609840164084	IFNGR1/CCR7/IL2RB/IL4R/TGFB1/IFNAR1/IL21R/FAS/TNFSF12/IFNGR2/TNFRSF10B/RELT/IL11RA/IL27RA/CXCR5/TNFSF8/ACVR1B	-3.31284752392039
NA	NA	hsa04082	Neuroactive ligand signaling	8/1106	199/9376	0.340799840068334	GNB5/GNG2/GNG8/GNAS/PRKCA/GNAI3/GNAI1/ADCY2	-3.43719303684228
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/1106	233/9376	0.363836739128748	CAPZA1/ATP1A1/SUN1/CAPZA2/TPM4/ANK3/ITGA6/ITGB7/LMNB1/LMNB2	-3.59594161740828
NA	NA	hsa04519	Cadherin signaling	23/1106	404/9376	0.482624030938356	PPP1CB/ARPC1B/CTNNB1/KRAS/VAV1/CDC42/VAV3/RELA/NFKB1/PCDH11X/YWHAE/IKBKB/YWHAQ/MOB1A/CSNK1A1/NF2/RAF1/PSEN1/YWHAG/WNT7A/RYK/ACTR3C/MAPK8	-3.88743150373617
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/1106	143/9376	0.0592824896622365	CD28	-4.14539840374924
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/1106	370/9376	0.252030692537022	GHRL/CYSLTR2/LPAR6/P2RY10/S1PR1/INSL3/PTGER4/P2RY8/CYSLTR1/ADM2/PGRMC2	-5.36820527902312
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1106	449/9376	0.132164303233627	OR11G2/CALM2/CALM3/OR2A25/OR52I1/OR7A17/CAMK2G	-6.89157298758564