category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/200	196/9376	5.74040816326531	HIF1A/CCR1/CXCL8/CLEC2B/IRF9/PLCG2/EIF2AK2/MAP1LC3B/STAT1/CXCL1/ZFP36/PREX1/GNG10/HLA-C/KRAS/E2F3/FOS/IFNGR1/HLA-B/NFKBIA/ICAM1/LYN/HCK/VEGFA	9.90139453646852
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/200	187/9376	5.51529411764706	NAMPT/NAIP/CXCL8/GABARAP/IFI16/IRF9/CARD16/OAS3/OAS2/MAP1LC3B/STAT1/CXCL1/CASP1/OAS1/TNFAIP3/BIRC2/NFKBIA/AIM2/CASP4/TXN/CARD8/GBP2	9.20760448464896
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/200	205/9376	5.0310243902439	ISG15/B2M/IRF9/PLCG2/OAS3/EIF2AK2/OAS2/CD58/STAT1/TLR2/OAS1/TNFAIP3/HLA-C/CD44/E2F3/HLA-B/MAP2K3/NFKBIA/ICAM1/CIR1/LYN/TAP2	8.61505279618632
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/200	180/9376	4.94844444444444	ZC3HAV1/B2M/IRF9/OAS3/EIF2AK2/OAS2/STAT1/TLR2/SP100/OAS1/HLA-C/BIRC2/IFNGR1/HLA-B/IFIH1/PPP1CB/TNFSF14/NFKBIA/TAP2	7.8965381266064
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/200	105/9376	6.25066666666667	BCL2A1/CXCL8/TNFSF13B/PLCG2/LY96/CXCL1/TNFAIP3/PLAU/BIRC2/TNFSF14/NFKBIA/ICAM1/LYN/BCL10	7.98766313460419
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/200	173/9376	4.60670520231214	MX1/RSAD2/MX2/CXCL8/IRF9/OAS3/EIF2AK2/OAS2/STAT1/CASP1/OAS1/IFNGR1/IFIH1/NFKBIA/TNFSF10/ADAR/ICAM1	7.06875485261921
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/200	238/9376	3.93949579831933	MX1/ISG15/MX2/CXCL8/ADAM17/IRF9/PLCG2/OAS3/CFD/EIF2AK2/OAS2/STAT1/TLR2/CASP1/OAS1/FOS/IFIH1/NFKBIA/ADAR/TLR8	6.78124880511055
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/200	136/9376	5.17058823529412	MX1/MX2/IRF9/OAS3/EIF2AK2/OAS2/STAT1/TLR2/OAS1/TNFAIP3/FOS/IFIH1/NFKBIA/ADAR/HSPA6	7.23277101735856
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/200	119/9376	5.12134453781513	ADAM17/IL18R1/MAP3K8/CXCL1/TNFAIP3/CREB5/FOS/EDN1/BIRC2/MAP2K3/NFKBIA/IRF1/ICAM1	6.67961151595692
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/200	56/9376	7.53428571428571	NAIP/CXCL8/CXCL1/TLR2/CASP1/RAB1A/NFKBIA/HSPA6/SEC22B	7.24032583598908
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/200	156/9376	4.20717948717949	MX1/IFIT1/RSAD2/MX2/IRF9/OAS3/EIF2AK2/OAS2/STAT1/OAS1/KRAS/E2F3/OCLN/NFKBIA	5.96340132911252
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/200	169/9376	3.88355029585799	HIF1A/IRS2/SH3GLB1/GABARAP/MAP1LC3B/KRAS/PTEN/WDFY3/VMP1/RAB1A/RRAGC/LAMP2/ATG2A/VPS18	5.58451864483778
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/200	216/9376	3.47259259259259	CXCL8/LY96/CXCL1/TLR2/CASP1/KRAS/DDIT3/FOS/MAP2K3/NFKBIA/NFE2L2/TNFSF10/ICAM1/HSPA6/LYN/CCL3L1	5.42757253530821
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/200	193/9376	3.64352331606218	CCR1/CXCL8/PLCG2/CXCR2/STAT1/CXCL1/PREX1/CXCR4/GNG10/KRAS/ARRB2/NFKBIA/LYN/CCL3L1/HCK	5.47827010435897
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/200	109/9376	4.73100917431193	CXCL8/IRF9/MAP3K8/LY96/STAT1/TLR2/FOS/MAP2K3/NFKBIA/TLR8/CCL3L1	5.78420821578229
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/200	100/9376	4.688	CCR1/CXCL8/IL18R1/CXCR2/CXCL1/CXCR4/IL18RAP/TNFSF14/TNFSF10/CCL3L1	5.47374392225753
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/200	248/9376	3.02451612903226	NAIP/CXCL8/LY96/TLR2/CASP1/FOS/BIRC2/MAP2K3/NFKBIA/CASP4/TNFSF10/ARPC1B/TXN/SNX18/CYTH1/VPS18	4.77016277940754
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/200	227/9376	3.09779735682819	CCR1/CXCL8/B2M/CXCR2/CXCR4/GNG10/HLA-C/KRAS/CREB5/E2F3/HLA-B/NFKBIA/CCL3L1/VEGFA/TAP2	4.72349633000235
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/200	90/9376	4.688	HIF1A/STAT1/TLR2/KRAS/PTEN/FOS/IFNGR1/MAP2K3/NFKBIA	5.19005262001839
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/200	214/9376	3.06691588785047	B2M/PLCG2/TLR2/CXCR4/GNG10/HLA-C/KRAS/FOS/HLA-B/MAP2K3/NFKBIA/APOBEC3A/LIMK2/TAP2	4.51552738151244
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/200	42/9376	6.69714285714286	ACSL1/FTH1/MAP1LC3B/ACSL4/PCBP1/FTL	5.46288162790733
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/200	105/9376	4.01828571428571	IRF9/PLCG2/STAT1/CASP1/KRAS/NFKBIA/IRF1/BCL10/CLEC7A	4.59161684796264
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/200	133/9376	3.52481203007519	FCGR3B/PLCG2/LCP2/HLA-C/KRAS/IFNGR1/HLA-B/CD48/TNFSF10/ICAM1	4.32934632402145
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/200	298/9376	2.51704697986577	CCR1/CXCL8/TNFSF13B/IL18R1/CXCR2/IL1R2/IL1RAP/CSF3R/CXCL1/CXCR4/IL18RAP/IFNGR1/TNFSF14/TNFSF10/IL1RN/CCL3L1	3.92903598694873
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/200	112/9376	3.76714285714286	LY96/STAT1/TLR2/BIRC2/IFNGR1/PPIF/MAP2K3/NFKBIA/HSPA6	4.34925881572535
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/200	69/9376	4.75594202898551	PLCG2/LCP2/KRAS/GAB2/MAP2K3/LYN/ALOX5AP	4.62287874710938
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/200	71/9376	4.62197183098592	CXCL8/ADAM17/PLCG2/CXCR2/CXCL1/NFKBIA/LYN	4.52261884027102
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/200	72/9376	4.55777777777778	ISG15/CXCL8/ZNFX1/IFIH1/NFKBIA/ADAR/AZI2	4.4738781248082
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/200	250/9376	2.62528	SH3GLB1/CXCR2/CXCR4/HLA-C/HLA-B/ARRB2/IST1/WIPF1/ARPC1B/VPS26A/SH3KBP1/HSPA6/CYTH1/CAPZA2	3.84531477669321
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/200	168/9376	3.06952380952381	IRF9/FTH1/EIF2AK2/STAT1/CASP1/TNFAIP3/BIRC2/IFNGR1/TNFSF10/FTL/ZBP1	3.99591596543537
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/200	95/9376	3.94778947368421	CXCL8/TNFSF13B/CXCL1/TLR2/FOS/ICAM1/CCL3L1/VEGFA	4.26319122761947
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/200	224/9376	2.72071428571429	B2M/IL1R2/ZFP36/HLA-C/KRAS/PTEN/CREB5/E2F3/FOS/ETS2/HLA-B/NFKBIA/ICAM1	3.84812083915797
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/200	98/9376	3.8269387755102	FCGR3B/MARCKS/PLCG2/GAB2/ARPC1B/LYN/LIMK2/HCK	4.15313635662073
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/200	200/9376	2.8128	NAIP/CXCL8/CASP1/FOS/OCLN/RAB1A/NFKBIA/CASP4/TNFSF10/WIPF1/ARPC1B/CYTH1	3.8257106636905
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/200	83/9376	3.95373493975904	IFI16/CASP1/PCBP1/NFKBIA/AIM2/ADAR/ZBP1	3.99030903478388
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/200	157/9376	2.9859872611465	CXCL8/ZFP36L1/HLA-C/KRAS/PTEN/E2F3/HLA-B/LIN54/PPP1CB/MAP2K3	3.70474491616325
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/200	163/9376	2.8760736196319	CXCL8/STAT1/TLR2/KRAS/CREB5/E2F3/FOS/IFIH1/MAP2K3/NFKBIA	3.56711472173367
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/200	137/9376	3.07970802919708	BCL2A1/LMNB1/MCL1/KRAS/DDIT3/FOS/BIRC2/NFKBIA/TNFSF10	3.62012946369355
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/200	138/9376	3.05739130434783	CXCL8/LCP2/CASP1/FOS/MAP2K3/NFKBIA/WIPF1/ARPC1B/FYB1	3.59452408363073
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/200	253/9376	2.40885375494071	NAIP/CXCL8/UBE2D1/PLCG2/MAP1LC3B/CASP1/CD44/NFKBIA/CASP4/RRAGC/ARPC1B/CYTH1/BCL10	3.35375451662912
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/200	195/9376	2.64451282051282	FCGR3B/PLCG2/FPR2/AQP9/TLR2/CASP1/PPIF/CASP4/FPR1/TLR8/CLEC7A	3.42596963278258
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/200	91/9376	3.60615384615385	IFITM1/PLCG2/KRAS/FOS/NFKBIA/LYN/BCL10	3.68810880601996
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/200	142/9376	2.9712676056338	FCGR3B/IRF9/PLCG2/LCP2/STAT1/FOS/IFNGR1/GAB2/NFKBIA	3.49436893452254
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/200	101/9376	3.24910891089109	CXCL8/PLCG2/STAT1/KRAS/EDN1/ICAM1/VEGFA	3.3549661875271
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/200	78/9376	3.60615384615385	FCGR3B/STAT1/TLR2/FOS/IFNGR1/NFKBIA	3.41213741834146
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/200	130/9376	2.88492307692308	GNG10/KRAS/CREB5/FOS/EDN1/ARRB2/NFKBIA/VEGFA	3.19493698398101
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/200	106/9376	3.09584905660377	IL1R2/KRAS/PTEN/CREB5/PLAU/E2F3/NFKBIA	3.20366429204011
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/200	82/9376	3.43024390243902	B2M/IFI30/HLA-C/HLA-B/HSPA6/TAP2	3.26309252099081
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/200	110/9376	2.98327272727273	HIF1A/PLCG2/PFKFB3/EDN1/IFNGR1/MKNK1/VEGFA	3.08891934110085
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/200	142/9376	2.64112676056338	KLF2/IL1R2/FOS/EDN1/NFE2L2/TXN/ICAM1/VEGFA	2.90914452879799
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/200	41/9376	4.57365853658537	CXCL8/KRAS/E2F3/VEGFA	3.38549170524978
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	14/200	333/9376	1.97093093093093	MX1/ISG15/MX2/IRF9/OASL/EIF2AK2/STAT1/HLA-C/KRAS/PTEN/CREB5/HLA-B/IRF1/VEGFA	2.66334925927221
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/200	205/9376	2.28682926829268	GTF2H2/IRF9/EIF2AK2/SP100/HLA-C/KRAS/CREB5/HLA-B/NFKBIA/LYN	2.75019474276822
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/200	66/9376	3.55151515151515	IL18R1/STAT1/TLR2/IL18RAP/IFNGR1	3.07092501781164
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/200	94/9376	2.99234042553191	CXCL8/S100A8/CXCL1/TNFAIP3/FOS/NFKBIA	2.86602929648724
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/200	122/9376	2.68983606557377	IRS2/PLCG2/STAT1/KRAS/CREB5/FOS/MAP2K3	2.77353516271019
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/200	155/9376	2.41961290322581	FCGR3B/TLR2/HLA-C/HLA-B/SEC22B/LAMP2/CLEC7A/TAP2	2.63099916204934
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/200	103/9376	2.73087378640777	CXCL8/TLR2/FOS/IFNGR1/NFKBIA/CCL3L1	2.60764109553632
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/200	133/9376	2.46736842105263	IRS2/GABARAP/KLF2/BCL6/KRAS/PTEN/TNFSF10	2.51612635079222
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/200	77/9376	3.04415584415584	STAT1/RALGDS/KRAS/E2F3/VEGFA	2.65898063947987
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/200	78/9376	3.00512820512821	CXCL8/LY96/CASP1/FOS/IRF1	2.62523756507578
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/200	300/9376	1.8752	LAMTOR3/MAP3K8/IL1RAP/KRAS/DDIT3/FOS/ARRB2/MAP2K3/DUSP6/MKNK1/HSPA6/VEGFA	2.27454548664416
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/200	201/9376	2.09910447761194	BCL2A1/NFKBIZ/CXCL8/IL1R2/BCL6/DDIT3/PLAU/BIRC2/DUSP6	2.32545480236719
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/200	109/9376	2.5805504587156	HIF1A/IL1RAP/STAT1/FOS/IFNGR1/NFKBIA	2.45033783666512
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/200	109/9376	2.5805504587156	IRS2/PTEN/CREB5/PPP1R3B/PPP1CB/NFKBIA	2.45033783666512
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/200	88/9376	2.66363636363636	CFD/PLAU/SERPINA1/F5/ITGAX	2.31479518793029
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/200	181/9376	2.07204419889503	FCGR3B/STAT1/TLR2/IFNGR1/LAMP2/BCL10/CLEC7A/ITGAX	2.1500573549692
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/200	149/9376	2.20241610738255	CXCL8/PLCG2/CXCR2/RALGDS/KRAS/GAB2/CYTH1	2.18419592665497
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/200	122/9376	2.3055737704918	MAP3K8/LCP2/KRAS/FOS/NFKBIA/BCL10	2.14284381410788
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/200	227/9376	1.85867841409692	HIF1A/KRAS/PTEN/ATP5F1E/FOS/PPIF/NFKBIA/NFE2L2/VEGFA	1.9334395309619
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/200	18/9376	5.20888888888889	ACSL1/ACSL4	2.63867636228881
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/200	99/9376	2.36767676767677	FCGR3B/CFD/FPR2/FPR1/ICAM1	2.01962725240441
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/200	99/9376	2.36767676767677	HIF1A/RALGDS/KRAS/FOS/GPCPD1	2.01962725240441
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/200	70/9376	2.67885714285714	IRS2/ACSL1/ACSL4/NFKBIA	2.08139818857032
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/200	71/9376	2.64112676056338	STAT1/KRAS/FOS/IRF1	2.04921273630572
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/200	71/9376	2.64112676056338	HIF1A/KRAS/PTEN/SLC7A5	2.04921273630572
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/200	73/9376	2.56876712328767	MX1/MX2/CXCR4/APOBEC3A	1.98647147165651
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/200	204/9376	1.83843137254902	HIF1A/PLCG2/TLR2/KRAS/CD44/PLAU/PPP1CB/VEGFA	1.78741136376997
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/200	21/9376	4.4647619047619	DSE/CSGALNACT2	2.34657846468289
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/200	21/9376	4.4647619047619	VNN2/DPYD	2.34657846468289
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/200	105/9376	2.23238095238095	HIF1A/GABARAP/RABGEF1/MAP1LC3B/KRAS	1.87477981864939
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/200	76/9376	2.46736842105263	PLCG2/KRAS/PTEN/E2F3	1.89617503306085
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/200	77/9376	2.43532467532468	KRAS/E2F3/GAB2/NFKBIA	1.86703011610747
NA	NA	hsa03272	Virion - Hepatitis viruses	3/200	48/9376	2.93	OCLN/IST1/LAMP2	1.97905376371646
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/200	323/9376	1.59653250773994	IRS2/MARCKS/PLCG2/MCL1/KRAS/PTEN/CD44/PLAU/E2F3/ZEB2/VEGFA	1.61069403331335
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/200	50/9376	2.8128	CXCL8/TLR2/ICAM1	1.89740972729958
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/200	80/9376	2.344	PLCG2/KRAS/PTEN/VEGFA	1.78225621679322
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/200	226/9376	1.65946902654867	HCAR3/HCAR2/CREB5/FOS/EDN1/PPP1CB/NFKBIA/FFAR2	1.48153531757301
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/200	158/9376	1.78025316455696	LAMTOR3/KRAS/PTEN/TBC1D7/RRAGC/SLC7A5	1.46022461115856
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/200	160/9376	1.758	CD58/SELL/HLA-C/OCLN/HLA-B/ICAM1	1.42768335923267
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/200	125/9376	1.8752	KRAS/PTEN/GAB2/NSMAF/SPTLC2	1.45425949691038
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/200	60/9376	2.344	PLCG2/KRAS/VEGFA	1.54182146502054
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/200	238/9376	1.57579831932773	PLCG2/RALGDS/GNG10/KRAS/SHOC2/ETS2/GAB2/VEGFA	1.32833381396848
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/200	93/9376	2.01634408602151	STAT1/FOS/IFNGR1/NFKBIA	1.45415933982333
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/200	93/9376	2.01634408602151	PTEN/E2F3/BIRC2/NFKBIA	1.45415933982333
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/200	62/9376	2.26838709677419	IRS2/KRAS/HSPA6	1.47929052943022
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/200	62/9376	2.26838709677419	ADAM17/DTX3L/CIR1	1.47929052943022
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/200	32/9376	2.93	GABARAP/ATG2A	1.61450657079456
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/200	133/9376	1.76240601503759	GNG10/CREB5/FOS/PPP1CB/ARRB2	1.30731303530606
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/200	170/9376	1.65458823529412	PLCG2/KRAS/PTEN/E2F3/FRAT2/NFE2L2	1.27154315583671
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/200	33/9376	2.84121212121212	STX11/SEC22B	1.56419738106401
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/200	99/9376	1.89414141414141	PLCG2/IL1RAP/PPP1CB/MAP2K3	1.32036487727355
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/200	250/9376	1.50016	LAMTOR3/LITAF/RRAGC/TLR8/VPS26A/LAMP2/VPS18/MCOLN1	1.18334849300482
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/200	212/9376	1.54792452830189	LCP2/RALGDS/KRAS/MAP2K3/FPR1/FYB1/VEGFA	1.1912970496531
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/200	138/9376	1.69855072463768	IRS2/KRAS/PPP1R3B/PPP1CB/MKNK1	1.22045689511835
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/200	139/9376	1.6863309352518	FKBP5/KRAS/CREB5/FOS/HSPA6	1.20350926053525
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/200	68/9376	2.06823529411765	BCL2A1/KRAS/DUSP6	1.30517012828894
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/200	103/9376	1.82058252427184	CXCL8/IL1R2/CXCL1/TLR2	1.23624537466193
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/200	69/9376	2.03826086956522	CREB5/FOS/PPP1CB	1.27790952864221
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/200	70/9376	2.00914285714286	HIF1A/KRAS/VEGFA	1.25110592274173
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/200	70/9376	2.00914285714286	HLA-C/HLA-B/ICAM1	1.25110592274173
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/200	144/9376	1.62777777777778	CXCL8/LY96/CXCL1/MAP2K3/NFKBIA	1.12076154207137
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/200	39/9376	2.40410256410256	HLA-C/HLA-B	1.29718342312376
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/200	73/9376	1.92657534246575	KRAS/PTEN/E2F3	1.17328790030428
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/200	73/9376	1.92657534246575	PLCG2/KRAS/E2F3	1.17328790030428
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/200	148/9376	1.58378378378378	KRAS/PTEN/E2F3/FOS/FRAT2	1.05682487138727
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/200	75/9376	1.8752	PTEN/CD82/SHISA5	1.1234326773784
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/200	76/9376	1.85052631578947	ACSL1/GK/ACSL4	1.09907419419883
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/200	232/9376	1.41448275862069	CXCR4/KRAS/PPP1CB/ARPC1B/LIMK2/ITGAX/SPATA13	0.943748527679464
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/200	115/9376	1.63060869565217	GNG10/KRAS/CREB5/FOS	1.00450907985291
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/200	43/9376	2.18046511627907	ACSL1/ACSL4	1.14538287700234
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/200	116/9376	1.61655172413793	PLCG2/CXCR4/OCLN/ICAM1	0.98643154351742
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/200	44/9376	2.13090909090909	HLA-C/HLA-B	1.11004504345473
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/200	157/9376	1.49299363057325	HIF1A/ADAM17/CASP1/ATP11B/VPS18	0.919651239612044
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/200	45/9376	2.08355555555556	HLA-C/HLA-B	1.07564082946139
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/200	46/9376	2.03826086956522	FTH1/FTL	1.04212187931883
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/200	122/9376	1.53704918032787	HIF1A/PLCG2/STAT1/KRAS	0.88146111690324
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/200	15/9376	3.12533333333333	ALPL	1.21614537958039
Organismal Systems	Immune system	hsa04611	Platelet activation	4/200	126/9376	1.48825396825397	PLCG2/LCP2/PPP1CB/LYN	0.81458071011343
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/200	87/9376	1.61655172413793	RALGDS/KRAS/FOS	0.852940222295068
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/200	168/9376	1.3952380952381	IRF9/CSF3R/STAT1/MCL1/IFNGR1	0.763140876969939
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/200	50/9376	1.8752	TNFSF13B/CXCR4	0.916048650337924
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/200	90/9376	1.56266666666667	IRS2/KRAS/CREB5	0.791830153885669
NA	NA	hsa04517	IgSF CAM signaling	8/200	299/9376	1.2543143812709	PLCG2/LCP2/IL1RAP/CD48/ARPC1B/ICAM1/LYN/ITGAX	0.659795394703091
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/200	17/9376	2.75764705882353	LAMP2	1.07081720980304
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/200	217/9376	1.29622119815668	BCL6/KRAS/CREB5/FOS/ARRB2/VEGFA	0.651772309037943
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/200	54/9376	1.7362962962963	HLA-C/HLA-B	0.801067071533108
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/200	55/9376	1.70472727272727	SAMD8/SPTLC2	0.773829181616232
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/200	57/9376	1.64491228070175	ACSL1/ACSL4	0.720986864698886
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/200	140/9376	1.33942857142857	KLF2/MAP1LC3B/GNG10/KRAS	0.597371344007537
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/200	20/9376	2.344	CYB5R4	0.888266111576046
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/200	99/9376	1.42060606060606	KRAS/E2F3/FOS	0.621102502142686
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/200	142/9376	1.32056338028169	UBE2D1/BIRC2/UBE2R2/UBE2B	0.568246905899779
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/200	59/9376	1.58915254237288	CMPK2/DPYD	0.670177198633551
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/200	59/9376	1.58915254237288	KRAS/PTEN	0.670177198633551
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/200	100/9376	1.4064	IL1R2/CSF3R/CD44	0.603180458244431
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/200	60/9376	1.56266666666667	KRAS/LYN	0.64548477999868
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/200	61/9376	1.53704918032787	FTH1/FTL	0.621242958941742
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/200	104/9376	1.35230769230769	PGS1/SAMD8/GPCPD1	0.533366847152424
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/200	235/9376	1.19693617021277	ACSL1/KRAS/CREB5/ATP5F1E/ACSL4/MAP2K3	0.451373957369967
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/200	23/9376	2.03826086956522	IDI1	0.735984843623075
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/200	24/9376	1.95333333333333	HS3ST3B1	0.690354378676375
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/200	65/9376	1.44246153846154	KRAS/ARRB2	0.528454954123739
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/200	67/9376	1.39940298507463	KRAS/PPP1CB	0.484363184866852
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/200	157/9376	1.1943949044586	IRS2/CXCL8/DDIT3/FOS	0.362632504301803
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/200	115/9376	1.22295652173913	CREB5/FOS/ARRB2	0.355151858900008
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	9/200	388/9376	1.08742268041237	IRS2/ADAM17/EIF2AK2/KRAS/DDIT3/ATP5F1E/FRAT2/PPIF/ATG2A	0.259646446049364
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/200	28/9376	1.67428571428571	B3GNT5	0.527518331323847
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/200	28/9376	1.67428571428571	ALPL	0.527518331323847
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/200	254/9376	1.10740157480315	PLCG2/CXCR4/HRH2/PPIF/VEGFA/MCOLN1	0.25618659843588
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/200	120/9376	1.172	PLCG2/KRAS/NFKBIA	0.279950553534915
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/200	166/9376	1.12963855421687	IRS2/CREB5/PPP1CB/PPIF	0.248789668519956
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/200	122/9376	1.1527868852459	IRS2/PFKFB3/CREB5	0.250769768300922
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/200	31/9376	1.51225806451613	DPYD	0.42174887412991
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/200	78/9376	1.20205128205128	PLCG2/PTEN	0.264538005278736
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/200	78/9376	1.20205128205128	PNPT1/TENT4B	0.264538005278736
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/200	32/9376	1.465	BIRC2	0.388987334414234
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/200	362/9376	1.03602209944751	CSF3R/TLR2/MCL1/GNG10/KRAS/PTEN/CREB5/VEGFA	0.103190202056904
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/200	174/9376	1.07770114942529	UBE2D1/DDIT3/NFE2L2/HSPA6	0.152733704868221
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/200	34/9376	1.37882352941176	NFIL3	0.326685912183308
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/200	35/9376	1.33942857142857	PFKFB3	0.29700219980444
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/200	83/9376	1.12963855421687	ACSL1/ACSL4	0.1751334851292
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/200	37/9376	1.26702702702703	ICAM1	0.24025909034383
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/200	37/9376	1.26702702702703	KRAS	0.24025909034383
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/200	86/9376	1.09023255813953	PLCG2/KRAS	0.124101940470659
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/200	184/9376	1.01913043478261	PLCG2/CXCR4/KRAS/LIMK2	0.0386903517168991
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/200	38/9376	1.23368421052632	NAMPT	0.213092500832197
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/200	38/9376	1.23368421052632	KRAS	0.213092500832197
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/200	38/9376	1.23368421052632	TAP2	0.213092500832197
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/200	89/9376	1.05348314606742	GABARAP/GNG10	0.0748424783193038
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/200	91/9376	1.03032967032967	GNG10/ARRB2	0.0429211515627218
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/200	191/9376	0.981780104712042	GNG10/KRAS/CREB5/PPP1CB	-0.0375575205535305
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/200	93/9376	1.00817204301075	KRAS/MAP2K3	0.0116923518648511
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/200	44/9376	1.06545454545455	GTF2H2	0.0642469800070261
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/200	44/9376	1.06545454545455	CREB5	0.0642469800070261
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/200	97/9376	0.96659793814433	GNG10/FOS	-0.0488182817215846
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/200	45/9376	1.04177777777778	TAP2	0.0414726160661896
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/200	98/9376	0.956734693877551	PLCG2/PTEN	-0.0635622948024542
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/200	150/9376	0.9376	KRAS/E2F3/FRAT2	-0.113735863098328
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/200	203/9376	0.923743842364532	PTEN/BIRC2/PPP1CB/VEGFA	-0.162159043585244
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/200	47/9376	0.997446808510638	IRS2	-0.00259053046565737
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/200	101/9376	0.928316831683168	KRAS/EDN1	-0.106928839574292
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/200	205/9376	0.914731707317073	PTEN/ATP5F1E/PPP1CB/PPIF	-0.182234283940821
NA	NA	hsa04518	Integrin signaling	3/200	154/9376	0.913246753246753	ICAM1/VEGFA/ITGAX	-0.160253481146708
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/200	154/9376	0.913246753246753	KRAS/FOS/PPP1CB	-0.160253481146708
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/200	103/9376	0.910291262135922	PPP1CB/EIF4A3	-0.13515034621245
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/200	49/9376	0.956734693877551	CREB5	-0.0448271126092171
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/200	51/9376	0.91921568627451	PLCG2	-0.0854007414647723
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/200	368/9376	0.891739130434783	MAP1LC3B/CASP1/DDIT3/ATP5F1E/RAB1A/MAP2K3/ATG2A	-0.312791660250683
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/200	268/9376	0.874626865671642	DDIT3/ATP5F1E/PPIF/NFE2L2/TXN	-0.307421546509708
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/200	110/9376	0.852363636363636	KRAS/CPEB4	-0.229941557111652
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/200	56/9376	0.837142857142857	ARRB2	-0.180454120092426
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	9/200	480/9376	0.879	MAP1LC3B/KRAS/DDIT3/ATP5F1E/FRAT2/RAB1A/PPIF/MAP2K3/ATG2A	-0.401774653732822
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/200	275/9376	0.852363636363636	CREB5/DDIT3/ATP5F1E/PPIF/HSPA6	-0.366850455846838
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/200	170/9376	0.827294117647059	OCLN/RAB8B/ARPC1B	-0.335482629900843
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/200	115/9376	0.815304347826087	GNG10/KRAS	-0.294205362052892
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/200	59/9376	0.794576271186441	IRS2	-0.233675133700766
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/200	63/9376	0.744126984126984	GTF2H2	-0.300831905688161
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/200	65/9376	0.721230769230769	GK	-0.332948670678795
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/200	65/9376	0.721230769230769	CREB5	-0.332948670678795
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/200	243/9376	0.771687242798354	PCBP1/EIF4A3/HSPA6/BCAS2	-0.53235399846433
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/200	69/9376	0.679420289855073	EDN1	-0.39457508059137
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/200	134/9376	0.699701492537313	EDN1/PPP1CB	-0.516888088781403
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/200	138/9376	0.679420289855073	CPEB4/PPP1CB	-0.560093496265932
NA	NA	hsa04082	Neuroactive ligand signaling	3/200	199/9376	0.706733668341708	GNG10/HRH2/OGFR	-0.617322793454052
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/200	75/9376	0.625066666666667	BIRC2	-0.481275546737972
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/200	75/9376	0.625066666666667	CREB5	-0.481275546737972
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/200	76/9376	0.616842105263158	HRH2	-0.495127483525216
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/200	78/9376	0.601025641025641	ARPC1B	-0.522361847986946
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/200	144/9376	0.651111111111111	KRAS/SKIL	-0.622865706567095
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/200	144/9376	0.651111111111111	PPIF/ATG2A	-0.622865706567095
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/200	82/9376	0.571707317073171	DPYD	-0.575069296152134
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/200	83/9376	0.564819277108434	UBE2D1	-0.587901624801737
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/200	85/9376	0.551529411764706	CMPK2	-0.613177390195787
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/200	86/9376	0.545116279069767	CREB5	-0.625627308145902
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/200	154/9376	0.608831168831169	CMPK2/ALPL	-0.722580067685454
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/200	154/9376	0.608831168831169	CREB5/PPP1CB	-0.722580067685454
NA	NA	hsa04382	Cornified envelope formation	3/200	217/9376	0.648110599078341	S100A8/OCLN/SPTLC2	-0.774258455478179
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/200	155/9376	0.604903225806452	CREB5/E2F3	-0.732241359225147
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/200	157/9376	0.597197452229299	BIRC2/PPP1CB	-0.751404966318677
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/200	89/9376	0.526741573033708	CD44	-0.662261593867453
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/200	89/9376	0.526741573033708	KRAS	-0.662261593867453
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/200	90/9376	0.520888888888889	AQP9	-0.674244001491904
NA	NA	hsa04519	Cadherin signaling	6/200	404/9376	0.696237623762376	KRAS/SHOC2/PPP1CB/MAP2K3/NFKBIA/ARPC1B	-0.921412214700558
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/200	98/9376	0.478367346938775	CREB5	-0.766345403372985
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/200	99/9376	0.473535353535354	EDN1	-0.777422248119039
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	4/200	308/9376	0.608831168831169	CREB5/ATP5F1E/PPIF/ATG2A	-1.03052321195594
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/200	370/9376	0.633513513513514	FPR2/EDN1/HRH2/OGFR/FPR1	-1.06185884698768
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/200	107/9376	0.438130841121495	CREB5	-0.862947898727377
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/200	108/9376	0.434074074074074	EIF4A3	-0.873277737571027
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/200	110/9376	0.426181818181818	SKIL	-0.893713736754153
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/200	116/9376	0.404137931034483	GNG10	-0.953329813869184
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/200	194/9376	0.483298969072165	KIF1B/CAPZA2	-1.07360736567816
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/200	138/9376	0.339710144927536	ATP5F1E	-1.15361029339403
NA	NA	hsa04081	Hormone signaling	2/200	219/9376	0.428127853881278	IRS2/GNG10	-1.26420739967344
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/200	143/9376	0.327832167832168	FCGR3B	-1.19577166785887
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/200	149/9376	0.314630872483221	GNG10	-1.2449770486158
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	2/200	233/9376	0.402403433476395	LMNB1/CAPZA2	-1.36368991204644
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/200	158/9376	0.296708860759494	E2F3	-1.31619207326362
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/200	178/9376	0.263370786516854	FRAT2	-1.46482644009857
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/200	183/9376	0.256174863387978	NOP10	-1.50017422380821
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/200	449/9376	0.208819599109131	OR11G2/ARRB2	-2.53641233802943