category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	30/335	250/9376	3.3585671641791	HLA-C/HLA-B/ARPC1B/SNX3/ARPC3/HSPA1A/CHMP5/SNX5/VPS36/HSPA8/WASHC4/SH3KBP1/VPS4B/TGFBR1/KIF5B/AP2M1/AP2A2/EPN1/PSD3/ARRB2/FOLR2/CHMP2A/CAV1/HSPA1B/CLTA/ARPC4/SMAP2/CYTH1/RABEP1/ARRB1	7.27575099283416
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	27/335	238/9376	3.17511601655588	ISG15/C1QC/C1QB/MX1/C1QA/OAS1/OAS2/RPS10/MX2/RPL36A/CXCL10/RPL41/FCGR2A/OAS3/RPS21/RPL17/IFIH1/IL6/SYK/EIF2AK2/RPS29/RPL26/TNFRSF1A/IFNAR1/RPL39/NFKBIA/CASP1	6.54252114787
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/335	82/9376	5.11976701856571	B2M/HSP90AB1/HLA-C/HLA-B/CD4/HSPA1A/LGMN/HSPA8/PSME1/CANX/PDIA3/TAP1/HSPA1B/HSPA5/CTSB	7.21237095372883
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	28/335	275/9376	2.84969335142469	C1QC/C1QB/C1QA/TUBA1B/PSMA2/IL6/HSPA1A/HSPA8/ATP5F1E/PSMA7/NDUFA7/UQCRB/KIF5B/PRKACB/NDUFV3/NCF4/ATP5PB/PSMD4/PSMA4/ATP5PO/NDUFA13/CAV1/GRIN2C/HSPA1B/NDUFS5/HSPA5/COX7A2/PSMD9	5.99268337657701
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/335	156/9376	3.58821278224263	IFIT1/MX1/RSAD2/OAS1/OAS2/IRF7/MX2/CXCL10/OAS3/EIF2AK2/TNFRSF1A/IFNAR1/NFKBIA/EIF3E/RB1/CD81/PPP2R1A/CLDN23/SCARB1/MAP2K2	6.27475283480841
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	20/335	173/9376	3.23561383832284	MX1/RSAD2/OAS1/OAS2/IRF7/MX2/CXCL10/OAS3/ACTB/IFIH1/IL6/EIF2AK2/TNFRSF1A/IFNAR1/NFKBIA/CASP1/XPO1/MAP2K2/ICAM1/DNAJC3	5.71287783123573
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	21/335	205/9376	2.8670695303968	B2M/ISG15/OAS1/OAS2/IRF7/HLA-C/CXCL10/HLA-B/OAS3/IL6/SYK/EIF2AK2/IFNAR1/NFKBIA/HDAC2/PSMD4/RB1/PDIA3/TAP1/CIR1/ICAM1	5.20270117733261
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/335	180/9376	2.9542951907131	B2M/OAS1/OAS2/IRF7/HLA-C/BST2/HLA-B/OAS3/IFIH1/IL6/SYK/EIF2AK2/TNFRSF1A/IFNAR1/NFKBIA/PPP1CC/PDIA3/TAP1/PTPN11	5.09596858006319
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/335	136/9376	3.29271290605795	MX1/OAS1/OAS2/IRF7/MX2/OAS3/IFIH1/IL6/HSPA1A/EIF2AK2/HSPA8/IFNAR1/EIF3H/NFKBIA/HSPA1B/MSN	5.18421436796481
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	24/335	268/9376	2.50639340610381	TUBA1B/UBC/PSMA2/UBE2L6/ATF6/ATP5F1E/PSMA7/NDUFA7/UQCRB/KIF5B/PRKACB/NDUFV3/ATP5PB/PSMD4/PSMA4/ATP5PO/NDUFA13/PARK7/TXN2/GNAS/NDUFS5/HSPA5/COX7A2/PSMD9	4.81608451054639
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/335	174/9376	2.89531652084406	HSP90AB1/DNAJA1/HSPA1A/ATF6/HSPA8/SSR1/OS9/HSPH1/RPN2/CANX/P4HB/HSP90B1/PDIA3/HSPA4L/HSPA1B/HSPA5/DNAJC3/BAG1	4.85752522991535
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	21/335	224/9376	2.62388059701493	B2M/HLA-C/HLA-B/CD4/IL6/ZFP36/ANAPC11/TNFRSF1A/TGFBR1/CANX/PRKACB/MAP3K1/NFKBIA/RB1/NFATC2/ANAPC16/XPO1/MAP2K2/ICAM1/SPI1/ADCY7	4.73499912626815
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	21/335	227/9376	2.58920376093103	B2M/HLA-C/HLA-B/CXCL12/IL6/CCL3L1/IL10RB/TNFRSF1A/PRKACB/NFKBIA/CCL4/GNA13/RB1/NFATC2/PDIA3/TAP1/GNAS/MAP2K2/GNB1/PTGER4/ADCY7	4.66557855454235
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	22/335	248/9376	2.48281174771305	HSP90AB1/ARPC1B/TUBA1B/ARPC3/ACTB/IL6/LY96/TNFRSF1A/KIF5B/MYL12A/NFKBIA/DYNC1I2/CASP1/RHOG/HSP90B1/BRK1/DCTN2/TXN2/ARPC4/MAP2K2/CYTH1/DCTN4	4.55537201967694
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/335	138/9376	3.04218040233614	FCGR2A/ARPC1B/ARPC3/ACTB/CD4/IL6/WAS/NFKBIA/SKAP2/CASP1/RHOG/NFATC2/ARPC4/MAP2K2/VAV1	4.65205108916956
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	21/335	250/9376	2.35099701492537	CTSC/LGMN/LAMTOR4/GNPTAB/GAA/AP2M1/HEXA/AP2A2/LAPTM5/MITF/PLA2G15/ATP6V1E1/LAMTOR1/VAMP8/ATP6V1F/GNS/DNASE2/CLTA/CTSH/CTSB/CD68	4.16758022495426
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/335	216/9376	2.46191265892758	IRF7/HSP90AB1/IL6/HSPA1A/CXCL1/ATF6/HSPA8/CCL3L1/LY96/TNFRSF1A/NFKBIA/NCF4/CASP1/NFATC2/HSP90B1/HSPA1B/HSPA5/ICAM1/VAV1	4.18408378517093
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/335	200/9376	2.51892537313433	FCGR2A/ARPC1B/TUBA1B/ARPC3/ACTB/IL6/PAK2/TNFRSF1A/NFKBIA/GNA13/CASP1/BRK1/HCLS1/PTPN11/ARPC4/CLDN23/CYTH1/TMED10	4.1795020192776
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/335	196/9376	2.42753579043558	IRF7/HLA-C/HLA-B/UBC/IL6/SYK/EIF2AK2/CXCL1/ZFP36/TNFRSF1A/IFNAR1/NFKBIA/RB1/NFATC2/MAP2K2/ICAM1/GNB1	3.88770683064249
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/335	103/9376	2.98901608462542	C1QC/C1QB/C1QA/IL6/CCL3L1/TNFRSF1A/TGFBR1/NFKBIA/GNAS/SERPINE1/PPP2R1A	3.90702854946801
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	25/335	368/9376	1.90136275146009	TUBA1B/ACTB/PSMA2/ATF6/ATP5F1E/PSMA7/NDUFA7/UQCRB/TNFRSF1A/KIF5B/NDUFV3/NUP62/ATP5PB/CASP1/PSMD4/PSMA4/ATP5PO/NDUFA13/DCTN2/GRIN2C/NDUFS5/HSPA5/COX7A2/DCTN4/PSMD9	3.3955422189601
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	22/335	308/9376	1.99914712153518	TUBA1B/PSMA2/ATP5F1E/PSMA7/NDUFA7/UQCRB/KIF5B/AP2M1/NDUFV3/AP2A2/ATP5PB/HDAC2/PSMD4/PSMA4/ATP5PO/NDUFA13/DCTN2/CLTA/NDUFS5/COX7A2/DCTN4/PSMD9	3.43201242261987
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/335	142/9376	2.56228715577044	FCGR3A/FCGR2A/SYK/TYROBP/TNFRSF1A/IFNAR1/TGFBR1/NFKBIA/MITF/NCF4/LILRB4/NFATC2/SPI1	3.61085381515447
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/335	78/9376	3.22939150401837	ARPC1B/ARPC3/ACTB/CTNNA1/RHOG/HCLS1/CAV1/CLTA/ARPC4	3.80573618252282
Organismal Systems	Immune system	hsa04611	Platelet activation	12/335	126/9376	2.66552949538024	FCGR2A/ACTB/SYK/APBB1IP/PRKACB/MYL12A/PPP1CC/TBXAS1/VAMP8/GNA13/GNAS/ADCY7	3.62298504570847
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/335	83/9376	3.03484984714979	IRF7/CXCL10/IL6/ZBP1/G3BP1/NFKBIA/CCL4/CASP1/DNASE2	3.58420839400392
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/335	116/9376	2.65404014410705	ACTB/CXCL12/AFDN/MYL12A/NCF4/CTNNA1/PTPN11/CLDN23/MSN/ICAM1/VAV1	3.45039927739986
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/335	100/9376	2.79880597014925	CXCL10/CXCL12/IL6/CXCL1/CCL8/CCL3L1/IL10RB/TNFRSF1A/CCL4/ACKR3	3.48099786897187
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/335	170/9376	2.30489903424056	ARPC1B/TUBA1B/ARPC3/ACTB/WAS/PRKACB/AFDN/MAP3K1/MYL12A/HCLS1/ARPC4/PPP2R1A/CLDN23/MSN	3.30495607809635
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	25/335	388/9376	1.80335436220957	TUBA1B/PSMA2/IL6/DKK2/EIF2AK2/ATF6/ATP5F1E/PSMA7/NDUFA7/UQCRB/RTN4/TNFRSF1A/KIF5B/NDUFV3/ATP5PB/CSNK1A1/PSMD4/PSMA4/ATP5PO/NDUFA13/GRIN2C/NDUFS5/MAP2K2/COX7A2/PSMD9	3.11093755888354
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/335	56/9376	3.49850746268657	IL6/HSPA1A/CXCL1/HSPA8/NFKBIA/CASP1/HSPA1B	3.60966181591752
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/335	155/9376	2.34738565238325	FCGR3A/HLA-C/FCGR2A/HLA-B/TUBA1B/ACTB/CANX/NCF4/ATP6V1E1/ATP6V1F/DYNC1I2/TAP1/SCARB1	3.25588130184572
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	29/335	480/9376	1.69094527363184	TUBA1B/UBC/PSMA2/IL6/DKK2/UBE2L6/ATF6/ATP5F1E/PSMA7/NDUFA7/UQCRB/TNFRSF1A/KIF5B/NDUFV3/ATP5PB/CSNK1A1/PSMD4/PSMA4/ATP5PO/NDUFA13/DCTN2/PARK7/GRIN2C/NDUFS5/HSPA5/MAP2K2/COX7A2/DCTN4/PSMD9	2.99134627278115
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/335	138/9376	2.43374432186892	ATP5F1E/NDUFA7/UQCRB/ATP5MF/NDUFV3/ATP5PB/ATP6V1E1/ATP6V1F/ATP5PO/NDUFA13/NDUFS5/COX7A2	3.26604438398831
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/335	157/9376	2.31748265044206	C1QC/C1QB/C1QA/CH25H/PLA2G15/CASP1/SGK1/NFATC2/RAB14/AXL/PTPN11/MAP2K2/PTGER4	3.20444358872725
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/335	105/9376	2.66552949538024	CXCL12/SYK/CXCL1/LY96/TNFRSF1A/UBE2I/NFKBIA/CCL4/ICAM1/PARP1	3.30356985281751
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/335	109/9376	2.5677118992195	IRF7/CXCL10/IL6/CCL3L1/LY96/IFNAR1/NFKBIA/CCL4/MAP3K8/MAP2K2	3.16890871788721
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/335	46/9376	3.65061648280337	PSMA2/PSMA7/PSME1/PSMD4/PSMA4/PSMD9	3.46884420814944
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/335	62/9376	3.15994222436206	HSPA1A/HSPA8/PRKACB/HDAC2/IGF1/HSPA1B/ADCY7	3.2845030503887
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/335	187/9376	2.09536275840051	OAS1/OAS2/IRF7/HSP90AB1/OAS3/IL6/CXCL1/IFNAR1/GPSM3/NFKBIA/GABARAP/CASP1/TXN2/CTSB	2.91235596402189
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/335	168/9376	2.16574271499645	FTL/HSP90AB1/FTH1/EIF2AK2/CHMP5/VPS4B/TNFRSF1A/ZBP1/IFNAR1/CASP1/CHMP2A/PARP1/GLUD1	2.93477291806685
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/335	133/9376	2.31480193019863	FCGR3A/HLA-C/HLA-B/SYK/TYROBP/IFNAR1/NFATC2/PTPN11/MAP2K2/ICAM1/VAV1	2.93954074305531
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/335	98/9376	2.57033201340238	FCGR3A/MARCKS/FCGR2A/ARPC1B/ARPC3/SYK/WAS/ARPC4/VAV1	3.00799524454391
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/335	50/9376	3.3585671641791	HBA2/HBA1/IL6/GYPC/CD81/ICAM1	3.21873595790519
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	16/335	232/9376	1.93021101389604	TMSB4X/ARPC1B/ARPC3/ACTB/CXCL12/DIAPH2/PAK2/PDGFC/MYL12A/PPP1CC/GNA13/BRK1/ARPC4/MSN/MAP2K2/VAV1	2.76157707119988
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/335	51/9376	3.29271290605795	ACTB/PRKACB/KDELR1/ATP6V1E1/ATP6V1F/GNAS	3.16016785100904
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	14/335	193/9376	2.03022194725853	CXCL10/CXCL12/CXCL1/CCL8/CCL3L1/WAS/PRKACB/NFKBIA/CCL4/ARRB2/VAV1/GNB1/ARRB1/ADCY7	2.7836649878645
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/335	235/9376	1.90557002222928	ACTB/ATP5F1E/NDUFA7/UQCRB/PRKACB/ATP5MF/NDUFV3/ATP5PB/ATP5PO/NDUFA13/GNAS/NDUFS5/MGLL/COX16/COX7A2/ADCY7	2.70619396414637
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/335	52/9376	3.22939150401837	PRKACB/ACOT2/IGF1/GNAS/SCARB1/ADCY7	3.10303510069327
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/335	53/9376	3.16845958884821	ATP1B1/PRKACB/AP2M1/AP2A2/GNAS/CLTA	3.04727208235622
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/335	70/9376	2.79880597014925	HLA-C/HLA-B/ACTB/EIF4G3/CAV1/ICAM1/EIF4G2	2.90771357024873
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/335	73/9376	2.68378654671846	MX1/MX2/BST2/CD4/VPS4B/TRIM5/XPO1	2.77994857327402
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/335	91/9376	2.46048876496638	IFITM1/SYK/NFKBIA/LILRB4/CD81/NFATC2/MAP2K2/VAV1	2.69480763827542
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	20/335	333/9376	1.68096454663619	ISG15/MX1/MX2/HLA-C/OASL/HLA-B/EIF2AK2/TNFRSF1A/IFNAR1/HES4/PRKACB/ATP6V1E1/ATP6V1F/HDAC2/CSNK1A1/RB1/GNAS/PPP2R1A/MAP2K2/PTGER4	2.43551136258637
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/335	42/9376	3.3319118692253	FTL/FTH1/PCBP2/SLC3A2/NCOA4	2.91543046037173
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/335	75/9376	2.61221890547264	ATP1B1/CANX/PRKACB/HSP90B1/GNAS/HSPA5/ADCY7	2.69829622733078
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/335	93/9376	2.40757502808538	ACTB/SNAI1/TGFBR1/WAS/AFDN/MYL12A/CTNNA1/PTPN1	2.62584241713521
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/335	44/9376	3.18046132971506	PRKACB/DYNC1I2/DCTN2/GNAS/DCTN4	2.79053304153907
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/335	214/9376	1.83099455991073	B2M/HLA-C/BST2/HLA-B/CD4/PAK2/TNFRSF1A/TRIM5/NFKBIA/NFATC2/PDIA3/TAP1/MAP2K2/GNB1	2.36706253018121
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/335	115/9376	2.19036988968202	MEF2A/WNK1/PRKACB/GNA13/ARRB2/SGK1/GNAS/ARRB1/ADCY7	2.47230312646066
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/335	137/9376	2.04292406580237	TUBA1B/CTSC/ACTB/TNFRSF1A/NFKBIA/LMNA/CTSH/MAP2K2/CTSB/PARP1	2.36701110891867
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/335	99/9376	2.2616613900196	C1QC/C1QB/C1QA/FCGR3A/FCGR2A/DEFB1/PTAFR/ICAM1	2.42916177706239
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/335	139/9376	2.01352947492752	HSP90AB1/HSPA1A/FKBP4/HSPA8/PRKACB/HSP90B1/HSPA1B/GNAS/MAP2K2/ADCY7	2.3172778935125
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/335	122/9376	2.06469292879863	CD4/PAK2/NFKBIA/MAP3K8/NFATC2/PTPN11/PPP2R1A/MAP2K2/VAV1	2.2784491710925
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/335	205/9376	1.77485256643611	ATP5F1E/NDUFA7/UQCRB/TGFBR1/NDUFV3/PPP1CC/NCF4/ATP5PB/ATP5PO/NDUFA13/NDUFS5/PARP1/COX7A2	2.15917312881197
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/335	105/9376	2.13242359630419	UBC/FIS1/TOMM7/TOMM20/MITF/GABARAP/BNIP3L/NBR1	2.24615683105368
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/335	106/9376	2.11230639256547	HSP90AB1/PDGFC/NFKBIA/FOLR2/IGF1/RB1/HSP90B1/MAP2K2	2.21685509244611
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/335	300/9376	1.58599004975124	TAOK3/HSPA1A/HSPA8/PAK2/TNFRSF1A/TGFBR1/PRKACB/MAP3K1/PDGFC/MAP3K8/STMN1/ARRB2/CACNA1G/IGF1/HSPA1B/MAP2K2/ARRB1	1.98565334858087
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/335	37/9376	3.02573618394514	HBA2/HBA1/IL6/ICAM1	2.37647564046938
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/335	130/9376	1.93763490241102	TGFBR1/PRKACB/NFKBIA/ARRB2/GNAS/MAP2K2/GNB1/ARRB1/ADCY7	2.07218394154178
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/335	72/9376	2.33233830845771	ISG15/IRF7/CXCL10/IFIH1/MAP3K1/NFKBIA	2.18446816367977
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/335	94/9376	2.08421721181327	HSP90AB1/CXCL10/S100A8/IL6/CXCL1/NFKBIA/HSP90B1	2.03357057522105
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/335	95/9376	2.06227808326787	CXCL12/IL6/CXCL1/CCL3L1/ATP6V1E1/ATP6V1F/ICAM1	2.0030991408922
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/335	77/9376	2.18088776894747	TGFBR1/NFKBIA/HDAC2/RB1/PTPN11/MAP2K2	2.00279118038853
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/335	78/9376	2.15292766934558	C1QC/C1QB/C1QA/IL6/LY96/CASP1	1.9681328017764
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/335	60/9376	2.33233830845771	GNA13/IGF1/GNAS/PPP2R1A/MAP2K2	1.99285273776693
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/335	227/9376	1.60284042343349	ATP5F1E/NDUFA7/UQCRB/NDUFV3/NFKBIA/ATP5PB/ATP5PO/NDUFA13/PTPN1/PTPN11/NDUFS5/MAP2K2/COX7A2	1.76981669722125
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/335	61/9376	2.2941032542207	FTL/FTH1/ATP1B1/MT2A/CYBRD1	1.95183105789073
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/335	163/9376	1.71705887739218	IRF7/IFIH1/IL6/IFNAR1/TGFBR1/MAP3K1/NFKBIA/RB1/NFATC2/MAP2K2	1.77765668583395
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/335	142/9376	1.77389110784108	HSP90AB1/ACTB/MEF2A/TNFRSF1A/BMPR2/HSP90B1/CAV1/TXN2/ICAM1	1.78866455436229
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/335	298/9376	1.50271461484524	CXCL10/CXCL12/CD4/IL6/CXCL1/TNFSF9/CCL8/CCL3L1/IL10RB/TNFRSF1A/IFNAR1/TGFBR1/BMPR2/CCL4/ACKR3/IL13RA1	1.69759606975798
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/335	65/9376	2.15292766934558	PRKACB/CACNA1G/GNAS/SCARB1/ADCY7	1.79539654093966
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/335	149/9376	1.69055394170089	SYK/PDGFC/GNA13/LPAR6/PTPN11/GNAS/MAP2K2/CYTH1/ADCY7	1.63553668424447
NA	NA	hsa03272	Virion - Hepatitis viruses	4/335	48/9376	2.33233830845771	VPS4B/CD81/CLDN23/SCARB1	1.78131478396722
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/335	89/9376	1.88683548549388	TUBA1B/PRKACB/PDGFC/GNAS/MAP2K2/ADCY7	1.61808059698313
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/335	15/9376	3.73174129353234	HEXA/ST3GAL5	2.03809245668501
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/335	69/9376	2.0281202682241	PRKACB/PPP1CC/HDAC2/GRIN2C/GNAS	1.64992201109884
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/335	133/9376	1.68349231287173	KIF5B/PRKACB/PPP1CC/ARRB2/GNAS/PPP2R1A/GNB1/ARRB1	1.5281035531702
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/335	201/9376	1.53168485928566	IL6/BMP2K/MAF/MITF/HDAC2/IGF1/ETV7/FLI1/LYL1/SPI1/AFF1	1.46672634412833
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/335	112/9376	1.74925373134328	HSPA1A/HSPA8/LY96/IL10RB/TNFRSF1A/NFKBIA/HSPA1B	1.53545983201782
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/335	91/9376	1.84536657372478	PRKACB/ARRB2/GNAS/GNB1/ARRB1/ADCY7	1.55982048932004
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/335	71/9376	1.97099011982342	CXCL1/NFKBIA/ATP6V1E1/ATP6V1F/PTPN11	1.58083158143115
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	9/335	157/9376	1.60441106569065	HLA-C/HLA-B/IL6/TGFBR1/PPP1CC/RB1/NFATC2/SERPINE1/MAP2K2	1.47007716857475
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/335	158/9376	1.59425656527489	LAMTOR4/TNFRSF1A/ATP6V1E1/LAMTOR1/ATP6V1F/SGK1/IGF1/SLC3A2/MAP2K2	1.45005337055591
NA	NA	hsa04517	IgSF CAM signaling	15/335	299/9376	1.40408326261668	ARPC1B/TUBA1B/ARPC3/ACTB/PAK2/MTSS1/AFDN/MYL12A/PTPN11/ARPC4/MSN/MAP2K2/ICAM1/VAV1/EPB41L2	1.36689481337449
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/335	205/9376	1.50179832544594	IRF7/HLA-C/HLA-B/SYK/EIF2AK2/HDAC9/PRKACB/NFKBIA/HDAC2/RB1/GTF2B	1.39829111668182
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/335	73/9376	1.91699039051319	PDGFC/MITF/IGF1/RB1/MAP2K2	1.51396038457561
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/335	140/9376	1.59931769722815	MEF2A/TGFBR1/PRKACB/GNA13/SERPINE1/MAP2K2/GNB1/ADCY7	1.37524148603913
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/335	97/9376	1.73122018772119	PRKACB/CACNA1G/GRIN2C/GNAS/GNB1/ADCY7	1.39342391475173
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/335	119/9376	1.64635645302897	CXCL10/IL6/CXCL1/TNFRSF1A/NFKBIA/MAP3K8/ICAM1	1.36587276348298
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/335	76/9376	1.84131971720346	ACTB/ATP1B1/PRKACB/GNAS/ADCY7	1.4175102114321
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/335	142/9376	1.57679209585873	UBC/UBE2L6/TRIP12/ANAPC11/MAP3K1/UBE2I/ANAPC16/UBE2K	1.33311723916425
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/335	98/9376	1.71355467560158	ATP1B1/PRKACB/CACNA1G/GNAS/SCARB1/ADCY7	1.36682501064293
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/335	56/9376	1.99914712153518	PRKACB/CSNK1A1/ARRB2/ARRB1	1.44349507333926
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/335	166/9376	1.5174249235749	GTF2I/MEF2A/ATP1B1/PPP1CC/GNA13/RGS2/NFATC2/MAP2K2/ADCY7	1.29470665458045
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/335	99/9376	1.6962460425147	PRKACB/IGF1/RB1/GNAS/MAP2K2/ADCY7	1.34052946954443
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/335	99/9376	1.6962460425147	PRKACB/PPP1CC/IGF1/GNAS/PTGER4/ADCY7	1.34052946954443
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/335	144/9376	1.55489220563847	C1QC/C1QB/C1QA/IL6/CXCL1/LY96/TNFRSF1A/NFKBIA	1.2916408737172
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	8/335	144/9376	1.55489220563847	PSMA2/PSMA7/PSMD4/PSMA4/PUM2/GRIN2C/GTF2B/PSMD9	1.2916408737172
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/335	19/9376	2.94611154752553	HEXA/GNS	1.63446649520025
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/335	169/9376	1.49048838647002	UBC/PRKACB/WDFY3/GABARAP/VAMP8/EIF2AK4/NBR1/MAP2K2/CTSB	1.23854792673451
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/335	79/9376	1.77139618363877	AP2M1/AP2A2/ATP6V1E1/ATP6V1F/CLTA	1.32531594547711
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/335	38/9376	2.20958366064415	ATP1B1/SGK1/IGF1	1.43813806763965
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/335	217/9376	1.41874957012174	HSP90AB1/PTGES3/KPNB1/PRKACB/ARRB2/RB1/HSP90B1/GNAS/MAP2K2/ARRB1/ADCY7	1.20132362724262
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/335	80/9376	1.74925373134328	IL6/PDGFC/IGF1/AXL/MAP2K2	1.29546492097897
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/335	59/9376	1.89749557298254	PRKACB/GNAS/MGLL/ADCY7	1.33112880116005
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/335	149/9376	1.50271461484524	NDUFA7/PRKACB/NDUFV3/NDUFA13/NDUFS5/MGLL/GNB1/ADCY7	1.19065020794762
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/335	105/9376	1.59931769722815	IL6/SYK/NFKBIA/CASP1/NFATC2/PTPN11	1.18874380928985
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/335	105/9376	1.59931769722815	ACTB/PRKACB/IGF1/LMNA/GNAS/ADCY7	1.18874380928985
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/335	62/9376	1.80568127106403	TLE4/HDAC2/NRARP/CIR1	1.22515434098356
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/335	154/9376	1.45392517929831	ACTB/PRKACB/PPP1CC/RGS2/NFATC2/GNAS/MAP2K2/ADCY7	1.09328120578605
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/335	204/9376	1.37196371085748	ACTB/PRKACB/PPP1CC/IGF1/HCLS1/CAV1/PTPN11/MSN/MAP2K2/VAV1	1.03391167523694
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/335	109/9376	1.5406271395317	HSP90AB1/CD4/IL6/TGFBR1/NFKBIA/NFATC2	1.09280158965519
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/335	109/9376	1.5406271395317	IL6/TNFRSF1A/NFKBIA/PPP1CC/PTPN1/PTPN11	1.09280158965519
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/335	23/9376	2.43374432186892	ATP6AP2/NLN	1.32513452399567
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/335	23/9376	2.43374432186892	ATP1B1/GLUD1	1.32513452399567
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/335	133/9376	1.47305577376276	IL6/TGFBR1/GABARAP/SGK1/IGF1/PRMT1/MAP2K2	1.05762448987516
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/335	157/9376	1.4261431695028	IL6/NDUFA7/UQCRB/TNFRSF1A/NDUFV3/NDUFA13/NDUFS5/COX7A2	1.03648556353663
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/335	110/9376	1.52662143826323	HSP90AB1/ANAPC11/PRKACB/IGF1/ANAPC16/ADCY7	1.06942057792038
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/335	65/9376	1.72234213547646	ARRB2/CACNA1G/MAP2K2/ARRB1	1.12486724526747
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/335	158/9376	1.41711694691101	ANAPC11/ESCO1/STAG2/STAG1/HDAC2/RB1/ANAPC16/PPP2R1A	1.01781262526653
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/335	88/9376	1.59023066485753	C1QC/C1QB/C1QA/CD59/SERPINE1	1.07078384148081
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/335	45/9376	1.86587064676617	HLA-C/HLA-B/IL6	1.12071448844594
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/335	67/9376	1.67092893740254	PRKACB/PPP1CC/GRIN2C/MAP2K2	1.06087011856835
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/335	90/9376	1.55489220563847	APPL1/SESN3/PRKACB/IGF1/ADCY7	1.01815839534266
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/335	90/9376	1.55489220563847	ATP1B1/PRKACB/GNAS/SCARB1/ADCY7	1.01815839534266
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/335	90/9376	1.55489220563847	CD4/NFKBIA/NFATC2/PTPN11/MAP2K2	1.01815839534266
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/335	138/9376	1.41968418775687	ANAPC11/PRKACB/PPP1CC/IGF1/ANAPC16/PPP2R1A/ADCY7	0.956033208686238
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/335	46/9376	1.82530824140169	FTL/FTH1/BLVRB	1.08007542083055
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/335	69/9376	1.62249621457928	PRKACB/GNAS/CTSB/PTGER4	0.998978658434724
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/335	93/9376	1.50473439255336	PRKACB/MAP3K1/GNAS/MAP2K2/ADCY7	0.941586026257069
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/335	93/9376	1.50473439255336	ATP1B1/PRKACB/GNAS/CST3/ADCY7	0.941586026257069
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/335	70/9376	1.59931769722815	APPL1/TNFRSF1A/NFKBIA/PTPN11	0.968778306298317
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/335	117/9376	1.43528511289705	ACTB/SMARCA5/YY1/HDAC2/SMARCA1/RBBP7	0.911978311436783
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/335	49/9376	1.71355467560158	PRKACB/GRIN2C/GNAS	0.963949128325354
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/335	195/9376	1.29175660160735	FCGR3A/FCGR2A/ACTB/SYK/HDAC9/NCF4/HDAC2/CASP1/MAP2K2	0.792488211610322
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/335	28/9376	1.99914712153518	ECHS1/ACOT2	1.01917535299771
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/335	28/9376	1.99914712153518	ATP6V1E1/ATP6V1F	1.01917535299771
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/335	50/9376	1.67928358208955	LAP3/P4HA1/AMD1	0.927018116970718
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/335	122/9376	1.37646195253242	PRKACB/MAP3K1/IGF1/GNAS/MAP2K2/ADCY7	0.805630807244317
Genetic Information Processing	Translation	hsa03010	Ribosome	10/335	222/9376	1.26072340997714	RPS10/RPL36A/RPL41/RPS21/RPL17/RPS29/RPL26/RPL39/MRPL53/MRPL41	0.756747278665422
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/335	52/9376	1.61469575200918	MYLIP/SCARB1/VAPA	0.855579870692748
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/335	226/9376	1.23840972130498	ATP1B1/PRKACB/AFDN/NFKBIA/PPP1CC/GRIN2C/GNAS/MAP2K2/VAV1/ADCY7	0.698340837958493
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/335	30/9376	1.86587064676617	IL6/FOLR2	0.91432493400427
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/335	101/9376	1.38554750997488	PRKACB/MITF/GNAS/MAP2K2/ADCY7	0.749862158170154
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/335	253/9376	1.21687216093446	ARPC1B/UBC/ARPC3/ACTB/TNFRSF1A/MYL12A/NFKBIA/CASP1/HCLS1/ARPC4/CYTH1	0.673123940547075
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/335	78/9376	1.43528511289705	FCGR3A/FCGR2A/NFKBIA/NCF4	0.743063881278788
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/335	31/9376	1.80568127106403	ALDOA/PGLS	0.864876843404708
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/335	31/9376	1.80568127106403	SEC11A/HSPA5	0.864876843404708
NA	NA	hsa04981	Folate transport and metabolism	2/335	31/9376	1.80568127106403	MTHFS/FOLR2	0.864876843404708
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/335	154/9376	1.27218453188602	ATP1B1/PRKACB/PPP1CC/CREM/GNAS/PPP2R1A/ADCY7	0.655557891008956
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/335	155/9376	1.26397688974482	PRKACB/CACNA1G/RB1/GNAS/SCARB1/MAP2K2/ADCY7	0.637885239403674
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/335	181/9376	1.23704131277315	FCGR3A/FCGR2A/IL6/SYK/IRAK2/IL10RB/TNFRSF1A/HSPA9	0.619850950376554
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/335	56/9376	1.49936034115139	RPN2/MGAT5/ST6GAL1	0.721439492479845
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/335	157/9376	1.24787527331495	ACTB/TGFBR1/PPP1CC/BMPR2/CTNNA1/SERPINE1/PPP2R1A	0.602893958498508
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/335	33/9376	1.6962460425147	VAMP8/VTI1B	0.771216552619447
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/335	107/9376	1.30785325707909	SIK1/PRKACB/PHKG1/GNAS/PRMT1	0.616480022664485
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/335	108/9376	1.29574350469873	KPNB1/UBE2I/NUP62/XPO1/RBM8A	0.59502318384504
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/335	83/9376	1.3488221542888	DCAF7/YY1/HDAC2/RBBP7	0.614419435010233
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/335	134/9376	1.2531967030519	PRKACB/PPP1CC/GNA13/GNAS/MAP2K2/ADCY7	0.568234071354108
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/335	212/9376	1.18817234581808	ACTB/APBB1IP/AFDN/PDGFC/IGF1/GNAS/MAP2K2/VAV1/ADCY7	0.533434372190608
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/335	110/9376	1.27218453188602	ALDOA/IL6/IGF1/SERPINE1/MAP2K2	0.55273051615693
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/335	86/9376	1.30177021867407	ATP1B1/PRKACB/GNAS/ADCY7	0.54114986357454
Genetic Information Processing	Transcription	hsa03040	Spliceosome	10/335	243/9376	1.15177200417665	HSPA1A/HSPA8/SYF2/SNU13/PHF5A/HSPA1B/RBM8A/CDC40/CWC15/DDX23	0.461410936595614
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/335	138/9376	1.21687216093446	PRKACB/PPP1CC/PHKG1/RHOQ/PTPN1/MAP2K2	0.494030973625823
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/335	13/9376	2.15292766934558	XRCC5	0.800693003414787
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/335	37/9376	1.51286809197257	NCOA4/MAP2K2	0.601666957922014
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/335	63/9376	1.33276474769012	PTGES3/TBXAS1/LTC4S	0.510108537560958
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/335	89/9376	1.25789032366259	PRKACB/GABARAP/GNB1/ADCY7	0.470535218418488
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/335	38/9376	1.47305577376276	CD4/TAP1	0.562441060093905
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/335	116/9376	1.20638188368502	PRKACB/GRIN2C/GNAS/GNB1/ADCY7	0.430521535328067
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/335	39/9376	1.43528511289705	HLA-C/HLA-B	0.524327028121379
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/335	93/9376	1.20378751404269	CD4/MAF/NFKBIA/NFATC2	0.380167229297687
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/335	120/9376	1.16616915422886	IRAK2/MAP3K1/NFKBIA/PTPN11/MAP2K2	0.352638046132486
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/335	41/9376	1.36527120495086	RB1/MAP2K2	0.451180178353356
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/335	203/9376	1.10297772222631	ACTB/PAK2/PDGFC/MYL12A/PPP1CC/IGF1/CAV1/VAV1	0.285519260880506
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/335	16/9376	1.74925373134328	HEXA	0.577365445611336
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/335	122/9376	1.14705162711035	ACTB/ATP1B1/PRKACB/HDAC2/MAP2K2	0.314691352628256
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/335	69/9376	1.21687216093446	SYK/MAP2K2/VAV1	0.348035305770607
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/335	178/9376	1.10065403320476	DKK2/DAAM1/TLE4/TBL1XR1/PRKACB/CSNK1A1/NFATC2	0.260972224449126
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/335	70/9376	1.19948827292111	PAK2/PTPN11/MAP2K2	0.32246655164818
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/335	17/9376	1.64635645302897	CH25H	0.513430463469904
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/335	17/9376	1.64635645302897	TXNRD1	0.513430463469904
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/335	17/9376	1.64635645302897	GLUD1	0.513430463469904
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/335	125/9376	1.1195223880597	TNFRSF1A/GNA13/DEGS1/PPP2R1A/MAP2K2	0.258946314899148
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/335	44/9376	1.27218453188602	RPN2/HEXA	0.348339096535618
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/335	44/9376	1.27218453188602	GTF2I/GTF2B	0.348339096535618
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/335	44/9376	1.27218453188602	RFC1/PARP1	0.348339096535618
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/335	44/9376	1.27218453188602	HLA-C/HLA-B	0.348339096535618
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/335	99/9376	1.1308306950098	ACTB/IL6/IGF1/LMNA	0.251897162026473
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/335	238/9376	1.05837200551863	PAK2/PRKACB/AFDN/PDGFC/RALBP1/IGF1/PTPN11/MAP2K2/GNB1	0.175576878494003
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/335	18/9376	1.55489220563847	HEXA	0.453579234482393
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/335	45/9376	1.24391376451078	DEFB1/TAP1	0.315702687046329
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/335	100/9376	1.1195223880597	CD4/IL6/CD59/CD33	0.23129630712518
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/335	73/9376	1.15019423430791	KIF5B/RB1/MAP2K2	0.2479721958772
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/335	184/9376	1.06476314081765	CXCL12/PAK2/MYL12A/BMPR2/NFATC2/DPYSL2/PTPN11	0.17077787815764
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/335	101/9376	1.1084380079799	IL6/TGFBR1/SERPINE1/ICAM1	0.2109041209909
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/335	103/9376	1.08691493986379	PPP1CC/PAPOLA/PPP2R1A/RBM8A	0.170727202282563
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/335	103/9376	1.08691493986379	IL6/CXCL1/PRKACB/GNAS	0.170727202282563
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/335	75/9376	1.1195223880597	SESN3/IGF1/SERPINE1	0.200039093753532
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/335	160/9376	1.04955223880597	HLA-C/HLA-B/CD4/SIGLEC1/CLDN23/ICAM1	0.12168914686885
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/335	76/9376	1.10479183032207	IGF1/RB1/MAP2K2	0.176560095429544
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/335	20/9376	1.39940298507463	CYP51A1	0.344176334296891
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/335	77/9376	1.09044388447374	TGFBR1/RALBP1/RB1	0.15339325116859
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/335	49/9376	1.14236978373439	GALNT1/ST6GAL1	0.192328960377047
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/335	191/9376	1.0257404079081	HDAC9/PRKACB/PPP1CC/HDAC2/GRIN2C/GNAS/GNB1	0.0691818761137717
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/335	78/9376	1.07646383467279	XRN2/XRN1/HSPA9	0.130529421029982
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	13/335	362/9376	1.00509606662818	HSP90AB1/IL6/SYK/IFNAR1/CDC37/PDGFC/SGK1/IGF1/HSP90B1/LPAR6/PPP2R1A/MAP2K2/GNB1	0.0190340152536555
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/335	50/9376	1.1195223880597	CXCL12/IL6	0.163112169992563
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/335	194/9376	1.00987844283736	TUBA1B/ACTB/KIF5B/MYL12A/DYNC1I2/DCTN2/DCTN4	0.0267621203219855
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/335	110/9376	1.01774762550882	TGFBR1/BMPR2/HDAC2/PPP2R1A	0.0360404543934827
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/335	254/9376	0.991702902808791	PRKACB/PDGFC/PTAFR/PHKG1/CACNA1G/NFATC2/GRIN2C/GNAS/ADCY7	-0.0258046402515882
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/335	168/9376	0.999573560767591	IL6/IL10RB/IFNAR1/PTPN2/PTPN11/IL13RA1	-0.00107356648630652
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/335	23/9376	1.21687216093446	GLUD1	0.200443540291189
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/335	23/9376	1.21687216093446	RFC1	0.200443540291189
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/335	170/9376	0.987813871817384	ACTB/TGFBR1/CSNK1A1/RB1/TXNRD1/MAP2K2	-0.0308641644669763
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/335	54/9376	1.03659480375898	AMD1/MTAP	0.0519112588052304
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/335	54/9376	1.03659480375898	HLA-C/HLA-B	0.0519112588052304
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/335	143/9376	0.978603486066173	C1QC/C1QB/C1QA/FCGR3A/FCGR2A	-0.0496294461857475
NA	NA	hsa04519	Cadherin signaling	14/335	404/9376	0.969883256982415	ARPC1B/ARPC3/ACTB/TAOK3/DAAM1/AFDN/NFKBIA/PPP1CC/CTNNA1/CSNK1A1/BRK1/ARPC4/MAP2K2/VAV1	-0.119111545673033
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/335	55/9376	1.01774762550882	HEXA/DEGS1	0.0254091509908346
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/335	85/9376	0.987813871817384	CMPK2/GMPR/NME4	-0.021724199477824
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/335	86/9376	0.976327664005554	ACTB/CTNNA1/LMNA	-0.0424504493855344
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/335	116/9376	0.965105506948019	ALDOA/ECHS1/PGLS/GLUD1	-0.0727914216838977
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/335	87/9376	0.965105506948019	ATP1B1/UQCRB/COX7A2	-0.0629407400850634
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/335	87/9376	0.965105506948019	APPL1/TGFBR1/MAP2K2	-0.0629407400850634
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/335	26/9376	1.07646383467279	SCARB1	0.0751513436421224
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/335	150/9376	0.932935323383084	TGFBR1/CTNNA1/CSNK1A1/RB1/MAP2K2	-0.15937953164503
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/335	27/9376	1.03659480375898	ECHS1	0.0366537599996958
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/335	27/9376	1.03659480375898	ACOT2	0.0366537599996958
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/335	59/9376	0.948747786491272	CMPK2/NME4	-0.076015191136768
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/335	59/9376	0.948747786491272	CTNNA1/MAP2K2	-0.076015191136768
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/335	60/9376	0.932935323383084	NFATC2/MAP2K2	-0.100312378286401
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/335	122/9376	0.91764130168828	RAB2A/IGF1/RAB14/PPP2R1A	-0.176248101987805
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/335	29/9376	0.965105506948019	RASSF4	-0.0362259328676846
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/335	29/9376	0.965105506948019	GNB1	-0.0362259328676846
NA	NA	hsa04081	Hormone signaling	7/335	219/9376	0.894595515572821	APPL1/PRKACB/GNA13/IGF1/GNAS/GNB1/ADCY7	-0.303811595691734
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/335	31/9376	0.902840635532017	ECHS1	-0.104297924584122
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/335	32/9376	0.874626865671642	GAA	-0.136745443698193
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/335	32/9376	0.874626865671642	ECHS1	-0.136745443698193
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/335	32/9376	0.874626865671642	GABARAP	-0.136745443698193
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/335	32/9376	0.874626865671642	TNFRSF1A	-0.136745443698193
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/335	66/9376	0.84812302125735	IL6/MAF	-0.238335581442895
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/335	99/9376	0.84812302125735	WAS/PDGFC/MAP2K2	-0.292418991732506
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/335	68/9376	0.823178226514486	MAP2K2/SPI1	-0.281683765893186
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/335	102/9376	0.823178226514486	ATP1B1/GNAS/ADCY7	-0.345622565312851
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/335	103/9376	0.815186204897841	ATP1B1/SLC7A8/SLC3A2	-0.363030133029644
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/335	35/9376	0.799658848614073	ALDOA	-0.228563726741293
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/335	36/9376	0.777446102819237	CRYL1	-0.257521102543788
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/335	36/9376	0.777446102819237	GAA	-0.257521102543788
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/335	36/9376	0.777446102819237	GALNT1	-0.257521102543788
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/335	36/9376	0.777446102819237	RFC1	-0.257521102543788
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/335	37/9376	0.756434045986285	GLUD1	-0.285737383351669
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/335	38/9376	0.736527886881382	HEXA	-0.313255947451836
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/335	39/9376	0.717642556448527	MTHFS	-0.340116477358848
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/335	144/9376	0.777446102819237	HESX1/BMPR2/IGF1/MAP2K2	-0.518046040803492
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/335	41/9376	0.682635602475428	GRIN2C	-0.392006058888235
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/335	148/9376	0.756434045986285	CSNK1A1/IGF1/RB1/MAP2K2	-0.574901515891897
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/335	42/9376	0.66638237384506	ECHS1	-0.417099377658789
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/335	115/9376	0.730123296560675	PRKACB/GNB1/ADCY7	-0.56051234448661
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/335	115/9376	0.730123296560675	PRKACB/GNAS/GNB1	-0.56051234448661
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/335	43/9376	0.650885109337036	ECHS1	-0.441663769744894
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/335	43/9376	0.650885109337036	SCARB1	-0.441663769744894
NA	NA	hsa04518	Integrin signaling	4/335	154/9376	0.726962589649157	ACTB/PDGFC/IGF1/ICAM1	-0.65761205332233
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/335	86/9376	0.650885109337036	PAK2/MAP2K2	-0.626050762345608
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/335	47/9376	0.59549063194665	CACNA1G	-0.535130584963401
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/335	48/9376	0.583084577114428	ECHS1	-0.557409181838883
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/335	48/9376	0.583084577114428	ATP1B1	-0.557409181838883
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/335	128/9376	0.655970149253731	GMPR/NME4/ADCY7	-0.754357145398947
NA	NA	hsa04082	Neuroactive ligand signaling	5/335	199/9376	0.703217580439511	PRKACB/GRIN2C/GNAS/GNB1/ADCY7	-0.814543252829943
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/335	233/9376	0.720722567420409	ACTB/DIAPH2/ATP1B1/DAAM1/LMNA/TMOD3	-0.83093920673345
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/335	93/9376	0.601893757021345	NFKBIA/RB1	-0.742670364621076
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/335	57/9376	0.491018591254255	ECHS1	-0.741915592392828
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/335	59/9376	0.474373893245636	LAP3	-0.779587187285176
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/335	183/9376	0.611760867792187	XRN2/XRN1/SNU13/XPO1	-1.02093014984395
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/335	63/9376	0.444254915896707	ECHS1	-0.851924111783067
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/335	63/9376	0.444254915896707	RFC1	-0.851924111783067
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/335	65/9376	0.430585533869116	MGLL	-0.886720641749087
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/335	66/9376	0.424061510628675	HSD17B11	-0.90380145744307
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/335	67/9376	0.417732234350635	ALDOA	-0.920679432868698
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/335	71/9376	0.394198023964684	MAP2K2	-0.986282842902858
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/335	71/9376	0.394198023964684	MAP2K2	-0.986282842902858
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/335	75/9376	0.373174129353234	ALDOA	-1.04908947303509
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/335	76/9376	0.368263943440691	UBC	-1.06439002057301
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/335	82/9376	0.341317801237714	NME4	-1.15313811113165
NA	NA	hsa04382	Cornified envelope formation	4/335	217/9376	0.515908934589724	S100A8/S100A12/PPP2R1A/CLDN23	-1.38877762774859
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/335	86/9376	0.325442554668518	PRKACB	-1.20965107530568
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/335	154/9376	0.363481294824578	CMPK2/NME4	-1.53305868287652
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/335	323/9376	0.519902037798623	MARCKS/UBE2I/BMPR2/HDAC2/STMN1/MAP2K2	-1.69018666390938
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/335	104/9376	0.269115958668197	PLA2G15	-1.44270735064729
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/335	370/9376	0.302573618394514	PTAFR/LPAR6/GRIN2C/PTGER4	-2.63471151337414
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/335	449/9376	0.311671043446465	PRKACB/RGS2/ARRB2/GNB1/ARRB1	-2.87717481436838