category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	68/1738	157/9376	2.33656080273834	SERPINE1/ID1/SMAD7/MYC/WNT4/PPP1CB/LLGL1/LATS2/GDF5/TEAD1/BBC3/WNT5A/CSNK1E/SMAD4/LLGL2/BMP2/CTNNB1/SAV1/DVL1/TGFB2/PPP2CB/WTIP/PPP2R2D/FRMD6/WNT6/TGFB3/STK3/YAP1/PPP2R1B/AXIN2/AJUBA/GLI2/SMAD2/SMAD3/FZD7/TEAD3/BMPR1A/BMP6/DLG4/TGFBR1/FZD2/GDF6/BTRC/YWHAQ/AXIN1/WNT9A/PARD3/PATJ/ACTB/BIRC2/AMH/CCND3/YWHAG/DLG5/WNT2B/WWTR1/FZD6/FZD1/PARD6G/NKD1/TCF7L2/WNT10A/WNT11/PPP2CA/LATS1/PRKCI/WNT7B/MOB1A	8.05596065350733
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	63/1738	142/9376	2.39342614953241	SOCS1/SOCS3/UBE2B/HERC4/UBE2S/RCHY1/SKP1/SYVN1/SMURF2/UBE2A/UBE2D1/SIAH1/UBE2N/PML/UBE2L6/ITCH/UBE2W/TRAF6/ELOC/CDC34/UBE3C/UBE2Q1/UBE2Q2/NEDD4/UBA3/UBE2Z/CBLB/CUL4A/MDM2/HERC3/FBXW7/ANAPC10/BTRC/CDC16/UBE2E1/UBE2J2/CDC26/ANAPC1/UBR5/BIRC2/UBA6/HERC2/UBE2M/PIAS2/UBE2H/SMURF1/UBE2D3/CUL3/CUL1/UBA2/COP1/BIRC6/UBE3B/CUL5/UBE2F/UBE2G1/UBE2I/ANAPC4/MID1/RNF7/UBE3A/ANAPC16/CUL2	7.98093714954834
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	67/1738	157/9376	2.30219961446278	IGFBP3/SERPINE1/MYC/GADD45A/SIRT1/ZFP36L1/RHEB/PPP1CB/ZFP36L2/PPP3CC/AKT1/GADD45B/GADD45G/TGFB2/TRAF3IP2/RAF1/TGFB3/GATA4/CDKN1A/TRPM7/HIPK3/MAPK14/SMAD2/SMAD3/MDM2/HIPK1/TGFBR1/RRAS2/MAP2K1/FOXO1/TSC1/PIK3CA/IL6/BTRC/PPID/HLA-F/VDAC2/RELA/PPP3CB/IL1A/CCND3/MCU/PPP3R1/LIN37/CDKN2A/RAD50/RRAS/CALM2/VDAC1/PTEN/RB1/CAPN2/CDKN2B/RBL1/AKT3/E2F5/CDK2/PIK3R2/VDAC3/HUS1/CCNA2/RBL2/LIN9/MAPKAPK2/ITPR3/ATR/RAD9A	7.84885269389294
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	69/1738	174/9376	2.13928018729416	PPP1R15A/XBP1/CRYAB/SEC23A/SEC61G/HSPA1B/SKP1/SEC24D/ERO1A/SYVN1/SEC24A/EIF2AK3/SAR1B/OSTC/DAD1/UBE2D1/SSR3/MAPK8/AMFR/UBQLN1/DNAJA1/ERN1/RNF5/ERO1B/TXNDC5/HSPA4L/EIF2S1/PDIA6/DERL2/PDIA4/MOGS/UBXN2A/FBXO6/SEC61B/DERL1/SEC24C/SAR1A/NGLY1/BCAP29/UBE2J2/KRTCAP2/HSPH1/MAPK9/HSPA8/HERPUD1/BAG2/UBE2D3/CUL1/RAD23B/SEC24B/CAPN2/TRAM1/HYOU1/UFD1/UBE2G1/ATXN3/SEC13/DNAJC1/DNAJB11/CALR/DDIT3/UGGT2/ERLEC1/ATF4/RAD23A/HSPA5/MAN1A1/MBTPS1/MBTPS2	7.23576996746619
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	55/1738	133/9376	2.230893689921	IRS2/GADD45A/SIRT1/BNIP3/KLF2/BCL6/AKT1/FBXO32/CSNK1E/SMAD4/IGF1R/INSR/GABARAPL1/GADD45B/GADD45G/TGFB2/MAPK8/SOD2/RAF1/IRS1/SOS2/TGFB3/ATG12/PLK2/CDKN1A/BRAF/STAT3/MAPK14/CDKN2D/SOS1/SMAD3/MDM2/TGFBR1/MAP2K1/FOXO1/PIK3CA/IL6/PRKAA1/PLK3/MAPK9/PRKAG2/DEPP1/GABARAPL2/CCNG2/SETD7/PTEN/ARAF/CDKN2B/AKT3/BCL2L11/CDK2/PIK3R2/PRKAB1/RBL2/PRKAB2	6.81962645011037
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	47/1738	110/9376	2.3050109844126	ID4/ID1/SMAD7/MYC/ID3/TGIF1/SKP1/SKI/GDF5/THBS1/SMAD6/SKIL/SMAD4/BMP2/SMURF2/TGFB2/PPP2CB/ACVR1B/TGFB3/PPP2R1B/DCN/SMAD2/SMAD3/IGSF1/BMPR1A/BMP6/RPS6KB1/TGFBR1/GDF6/ZFYVE9/TFRC/LEMD3/AMH/ACVR2B/SMURF1/CUL1/FMOD/CDKN2B/RBL1/E2F5/SIN3A/PPP2CA/INHBB/GREM1/PITX2/BAMBI/TFDP1	6.56727283202356
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	97/1738	300/9376	1.74428845416187	DUSP1/JUN/VEGFA/FOS/DUSP8/JUND/PLA2G4A/FAS/MYC/GADD45A/PDGFA/MKNK2/HSPA1B/DUSP7/IL1R1/MAP4K3/NR4A1/PPP3CC/AKT1/IL1RAP/IGF1R/INSR/DUSP5/GADD45B/GADD45G/TGFB2/MAPK8/ATF2/RAF1/SOS2/FGF2/TRAF6/TGFB3/RAP1B/STK3/MAP3K8/GDNF/BRAF/CACNA2D1/GNA12/PDGFRB/CACNB2/MAPK7/CASP3/MAPK14/SOS1/MAP3K12/TGFBR1/RRAS2/DUSP9/MAP2K1/RASA2/FGFR2/LAMTOR3/MAPKAPK5/MAPK8IP3/FGFR4/MAP3K7/RELA/PPP3CB/PPM1B/FGFR3/IL1A/MAPK9/PPM1A/CRKL/HSPA8/DUSP16/CACNA1A/PPP3R1/ELK4/RET/GNG12/PRKCA/CSF1/RRAS/MAX/ARAF/RAPGEF2/AKT3/FGF22/IRAK4/FGF10/EPHA2/MAP3K4/NF1/VEGFB/RAP1A/MAP3K2/MAPT/DDIT3/MYD88/MAPKAPK2/ATF4/MAP2K4/TAB2/KITLG	6.24993301903343
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	38/1738	83/9376	2.46986565363872	PHF1/SKP1/BMI1/AEBP2/OGT/FOXK1/PHC2/CBX8/PHC3/FBRS/UBE2D1/ASXL1/CBX4/SCMH1/PCGF3/KDM2A/PHF19/FOXK2/MBD5/PHC1/SCML1/FBRSL1/PCGF5/WDR5/RNF2/RYBP/CSNK2B/CBX7/UBE2D3/MAX/PCGF6/RING1/L3MBTL3/PCGF1/LCOR/BCOR/MGA/TFDP1	6.41592704103951
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	39/1738	87/9376	2.41831673346296	JUN/FOS/MYC/GADD45A/AKT1/BBC3/SMAD4/CTNNB1/CYCS/GADD45B/POLK/GADD45G/TGFB2/MAPK8/RAF1/SOS2/TGFB3/AXIN2/CDKN1A/BRAF/CASP3/SMAD2/SOS1/SMAD3/RPS6KB1/TGFBR1/MAP2K1/PIK3CA/AXIN1/MLH1/MAPK9/RALA/ARAF/AKT3/TCF7L2/MSH6/BCL2L11/RALB/PIK3R2	6.33970528006907
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	64/1738	178/9376	1.93966977411722	JUN/MYC/DKK1/SIRT1/TLE4/PRICKLE2/WNT4/SKP1/PPP3CC/CTBP2/WNT5A/CSNK1E/SMAD4/CTNNB1/TLE2/PLCB1/DVL1/SIAH1/RYK/DAAM2/MAPK8/INVS/CAMK2D/WNT6/MCC/CACYBP/LZTS2/AXIN2/TLE1/SMAD3/FZD7/FZD2/CTBP1/APCDD1/BTRC/AXIN1/WNT9A/CSNK2A2/MAP3K7/ROR2/PPP3CB/CSNK2B/CSNK1A1/MAPK9/CCND3/PLCB3/PSEN1/CSNK2A1/WNT2B/PPP3R1/PRKCA/CUL1/TBL1X/FZD6/FZD1/NKD1/TCF7L2/WNT10A/WNT11/LGR4/PPARD/WNT7B/BAMBI/TBL1XR1	6.03752932412543
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	53/1738	144/9376	1.98555171972893	ID4/KLF4/ID1/MEIS1/MYC/ID3/WNT4/BMI1/SKIL/AKT1/WNT5A/SMAD4/IGF1R/CTNNB1/DVL1/ACVR1B/RAF1/PCGF3/FGF2/WNT6/AXIN2/TBX3/STAT3/MAPK14/SMAD2/SMAD3/FZD7/BMPR1A/DUSP9/FZD2/MAP2K1/PCGF5/FGFR2/PIK3CA/AXIN1/WNT9A/FGFR4/LIF/FGFR3/ACVR2B/WNT2B/FZD6/FZD1/PCGF6/AKT3/PCGF1/WNT10A/WNT11/PIK3R2/JAK2/INHBB/SMARCAD1/WNT7B	5.68503922426723
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	100/1738	333/9376	1.62003199977884	MX2/MX1/ISG15/STAT1/VEGFA/HES1/EIF2AK2/HES4/STAT2/FAS/IRF9/RHEB/WNT4/LLGL1/MAML2/THBS1/TBK1/AKT1/WNT5A/PTK2/LLGL2/OASL/ITGA1/IRF1/CTNNB1/ITGB8/DVL1/TBPL1/PPP2CB/RAF1/PPP2R2D/COL6A3/SOS2/WNT6/PPP2R1B/COL6A6/AXIN2/HEYL/CDKN1A/PDGFRB/CASP3/SOS1/MAML1/MDM2/FZD7/RPS6KB1/FZD2/MAP2K1/FOXO1/ITGA3/TSC1/PIK3CA/ATP6V1E2/AXIN1/WNT9A/PARD3/ATP6V1D/PATJ/NOTCH2/COL4A6/HLA-F/LAMA5/RELA/CSNK1A1/PPP2R3C/PXN/CCND3/PSEN1/ITGA11/WNT2B/THBS2/COL4A1/ITGAV/PTEN/CREB3L2/FZD6/RB1/FZD1/PARD6G/RBL1/AKT3/TCF7L2/WNT10A/WNT11/CDK2/PPP2R3A/PIK3R2/TNC/ATP6V1G1/PPP2CA/LAMC3/CCNA2/ATP6V0A2/RBL2/TICAM1/UBE3A/PRKCI/ATR/MAGI1/WNT7B	5.49541699551793
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	68/1738	204/9376	1.79823551975451	TIMP3/VEGFA/DDX5/FAS/MYC/HOXD10/WNT4/PPP1CB/PLCG2/THBS1/AKT1/LUM/WNT5A/PTK2/IGF1R/HSPB2/CTNNB1/TGFB2/TFAP4/RAF1/SOS2/CAMK2D/TWIST1/FGF2/WNT6/CTTN/VAV2/CDKN1A/BRAF/STAT3/DCN/CASP3/MAPK14/SMAD2/SOS1/MDM2/FZD7/RPS6KB1/RRAS2/FZD2/MAP2K1/PIK3CA/ARHGEF12/SDC4/TWIST2/WNT9A/FRS2/ACTB/CAV2/PXN/PPP1R12B/WNT2B/PRKCA/RRAS/ITGAV/FZD6/FZD1/ARAF/AKT3/WNT10A/WNT11/HSPG2/PIK3R2/ANK3/PLAU/SDC2/ITPR3/WNT7B	5.49838070618855
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	33/1738	77/9376	2.31201709682722	NFKBIA/MYC/GADD45A/STAT5B/AKT1/CTBP2/ABL1/SMAD4/GADD45B/POLK/SHC2/GADD45G/TGFB2/RAF1/SOS2/TGFB3/CDKN1A/BRAF/SOS1/SMAD3/MDM2/TGFBR1/CTBP1/MAP2K1/PIK3CA/RELA/CRKL/CDKN2A/RB1/ARAF/AKT3/PIK3R2/GAB2	5.51426242346336
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	58/1738	170/9376	1.84054694374873	MGST1/MYC/GADD45A/WNT4/PLCG2/GSTT2B/AKT1/WNT5A/SMAD4/GSTA1/IGF1R/CTNNB1/GADD45B/POLK/SHC2/ARID1B/GADD45G/DVL1/TGFB2/RAF1/SOS2/WNT6/TGFB3/AXIN2/PHF10/CDKN1A/BRAF/SMAD2/SOS1/SMAD3/FZD7/RPS6KB1/TGFBR1/FZD2/MAP2K1/ARID2/PIK3CA/AXIN1/WNT9A/ACTB/CSNK1A1/WNT2B/PRKCA/CDKN2A/PTEN/FZD6/RB1/FZD1/ARAF/SMARCD3/AKT3/TCF7L2/WNT10A/WNT11/PIK3R2/ACTL6A/SMARCE1/WNT7B	5.27559740589771
Human Diseases	Infectious disease: viral	hsa05162	Measles	49/1738	136/9376	1.94368103973465	MX2/MX1/OAS2/OAS1/IRF7/OAS3/STAT1/NFKBIA/JUN/EIF2AK2/FOS/IFIH1/STAT2/FAS/IRF9/STAT5B/RCHY1/HSPA1B/TBK1/AKT1/BBC3/RAB9A/CYCS/ADAR/MAPK8/TRAF6/EIF2S1/STAT3/CBLB/CASP3/PIK3CA/IL6/CSNK2A2/MAP3K7/RELA/CSNK2B/IL1A/MAPK9/CCND3/HSPA8/CSNK2A1/CD46/APAF1/AKT3/IRAK4/CDK2/PIK3R2/MYD88/TAB2	5.28785326464439
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	33/1738	78/9376	2.28237585199611	TOB1/BTG2/PAN3/MPHOSPH6/PNPT1/PFKP/ENO2/BTG3/CNOT8/CNOT2/HSPA9/DDX6/C1D/CNOT6/TENT4B/LSM1/TENT4A/DCP1A/PATL1/EXOSC3/XRN1/PAN2/TOB2/CNOT10/LSM8/EXOSC6/ZCCHC7/CNOT4/LSM6/DCP2/BTG1/EXOSC9/EXOSC10	5.42486030287851
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	56/1738	163/9376	1.85339611851998	IRF7/STAT1/NFKBIA/JUN/FOS/IFIH1/STAT2/FAS/MYC/STAT5B/TBK1/AKT1/SMAD4/CYCS/TGFB2/MAPK8/ATF2/RAF1/SOS2/TRAF6/TGFB3/CDKN1A/BRAF/STAT3/CASP10/CASP3/MAPK14/SOS1/SMAD3/TGFBR1/MAP2K1/PIK3CA/DDX3X/IL6/YWHAQ/MAP3K7/RELA/MAPK9/PRKCA/CREB3L2/APAF1/RB1/ARAF/AKT3/IRAK4/HSPG2/CDK2/PIK3R2/VDAC3/CCNA2/TICAM1/MYD88/JAK2/ATF4/MAP2K4/TAB2	5.24281613228956
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	52/1738	148/9376	1.89543743974124	JUN/HES1/FOS/MYC/DLL4/GADD45A/WNT4/AKT1/WNT5A/IGF1R/CTNNB1/GADD45B/POLK/SHC2/GADD45G/DVL1/RAF1/SOS2/FGF2/WNT6/AXIN2/HEYL/CDKN1A/BRAF/SOS1/FZD7/RPS6KB1/FZD2/MAP2K1/PIK3CA/AXIN1/WNT9A/NOTCH2/NCOA3/CSNK1A1/WNT2B/PTEN/FZD6/RB1/FZD1/ARAF/AKT3/FGF22/FGF10/TCF7L2/ESR2/WNT10A/WNT11/PIK3R2/WNT7B/PGR/NCOA1	5.23760823825819
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	52/1738	150/9376	1.87016494054469	MYC/GADD45A/WNT4/AKT1/WNT5A/SMAD4/CTNNB1/GADD45B/POLK/SHC2/GADD45G/DVL1/TGFB2/RAF1/SOS2/FGF2/WNT6/TGFB3/AXIN2/CDKN1A/BRAF/SMAD2/SOS1/SMAD3/FZD7/RPS6KB1/TGFBR1/FZD2/MAP2K1/FGFR2/PIK3CA/RARB/AXIN1/MLH1/WNT9A/CSNK1A1/WNT2B/FZD6/RB1/FZD1/ARAF/CDKN2B/AKT3/FGF22/FGF10/TCF7L2/WNT10A/RXRB/WNT11/CDK2/PIK3R2/WNT7B	5.124614286178
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	54/1738	158/9376	1.84376046962171	GRB10/DDIT4/RHEB/WNT4/FLCN/AKT1/WNT5A/LPIN1/IGF1R/INSR/RICTOR/CASTOR1/DVL1/CAB39L/RAF1/LPIN3/IRS1/ULK1/SOS2/FNIP1/DEPTOR/WNT6/EIF4E/BRAF/SOS1/FZD7/RPS6KB1/FZD2/MAP2K1/TSC1/TBC1D7/PIK3CA/LAMTOR3/ATP6V1E2/WDR59/WNT9A/ATP6V1D/PRKAA1/RNF152/WNT2B/CAB39/PRKCA/PTEN/SLC38A9/FZD6/FZD1/AKT3/SLC3A2/WNT10A/WNT11/SEC13/PIK3R2/ATP6V1G1/WNT7B	5.10211288892254
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	32/1738	77/9376	2.24195597268094	STAT1/VEGFA/GADD45A/AKT1/SMAD4/GADD45B/POLK/GADD45G/TGFB2/MAPK8/RAF1/TGFB3/ARHGEF6/CDKN1A/BRAF/STAT3/PLD1/SMAD2/SMAD3/RPS6KB1/TGFBR1/MAP2K1/PIK3CA/RELA/MAPK9/RALA/CDKN2A/RB1/ARAF/AKT3/RALB/PIK3R2	5.21980328481365
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	59/1738	180/9376	1.7682649277586	OAS2/OAS1/IRF7/OAS3/SOCS3/STAT1/NFKBIA/EIF2AK2/IFIH1/STAT2/SRSF6/FAS/IRF9/RHEB/PPP1CB/SRSF7/TAP2/TBK1/AKT1/TAP1/B2M/IFNGR2/BST2/CYCS/SP100/ZC3HAV1/SRSF1/IFNGR1/SRSF9/PML/NXF1/TRAF6/SRSF3/CGAS/EIF2S1/CASP3/RNASEL/SRSF5/EIF2B1/TSC1/PIK3CA/IL6/MAP3K7/HLA-F/RELA/BIRC2/EIF2B2/ALYREF/APAF1/AKT3/IRAK4/NECTIN1/CALR/PIK3R2/TICAM1/MYD88/JAK2/SRSF2/TAB2	4.96441953678822
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	108/1738	388/9376	1.50161935154758	COX7A1/IRS2/PSMA2/EIF2AK2/XBP1/FAS/DKK1/TUBB2A/SLC39A14/WNT4/TUBB4B/PSMD9/PPP3CC/AKT1/EIF2AK3/WNT5A/CSNK1E/INSR/CTNNB1/PLCB1/CYCS/DVL1/SDHB/SLC39A13/MAPK8/NDUFA7/RAF1/NDUFC2/IRS1/SDHD/ULK1/SDHA/ERN1/WNT6/PSMA3/AXIN2/CASP7/KLC1/EIF2S1/MME/BRAF/CASP3/NDUFS4/FZD7/PSMD11/FZD2/MAP2K1/NDUFA13/PIK3CA/IL6/NAE1/NDUFA5/PSMC6/AXIN1/NDUFB3/WNT9A/NDUFB5/CSNK2A2/PPID/VDAC2/RELA/PPP3CB/CSNK2B/CSNK1A1/IL1A/MAPK9/PLCB3/MCU/PSEN1/CSNK2A1/BACE2/WNT2B/PSMA1/PPP3R1/CSF1/SLC39A6/KLC2/CALM2/VDAC1/ATP2A2/PSMB2/KLC4/FZD6/APAF1/FZD1/CAPN2/ARAF/AKT3/COX7A2L/NCSTN/ATG101/PSMA5/WNT10A/WNT11/PIK3R2/NDUFV3/VDAC3/MAPT/DDIT3/ATG2B/TUBB2B/ATG13/RTN3/ITPR3/ATF4/NDUFB8/ADAM17/WNT7B	4.81370321386995
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	56/1738	169/9376	1.78759507289205	IRS2/DDIT4/BNIP3/RHEB/TBK1/AKT1/EIF2AK3/IGF1R/GABARAPL1/TANK/RAB33B/SUPT20H/MAP1LC3C/MAPK8/PPP2CB/MTMR3/RAF1/IRS1/ULK1/ERN1/DEPTOR/TRAF6/ATG12/EIF2S1/WDFY3/RAB1A/CALCOCO2/RPS6KB1/PRKCD/DAPK1/RRAS2/MAP1LC3B/MAP2K1/EPG5/TSC1/PIK3CA/ATG5/PRKAA1/MAP3K7/RAB8A/MAPK9/GABARAPL2/GORASP1/ATG16L1/RRAS/PTEN/BIRC6/STX7/AKT3/ATG101/PIK3R2/PPP2CA/ATG2B/ATG13/MTMR4/GORASP2	4.92842291909022
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	69/1738	224/9376	1.66176228834457	ZFP36/EGR1/NFKBIA/JUN/FOS/MYC/MSX1/STAT5B/IL15RA/ADCY9/IL1R1/PPP3CC/AKT1/CRTC3/SMAD4/B2M/CRTC2/ETS2/TGFB2/MAPK8/TBPL1/ATF2/TGFB3/NFYB/IL15/CDKN1A/SMAD2/SMAD3/TGFBR1/MAP2K1/ANAPC10/PIK3CA/IL6/CDC16/TRRAP/CDC26/HLA-F/VDAC2/RELA/XPO1/PPP3CB/ANAPC1/BUB3/MAPK9/CCND3/PPP3R1/ELK4/CDKN2A/KAT2A/VDAC1/PTEN/CREB3L2/RB1/MSX2/CDKN2B/AKT3/CDK2/RANBP1/CALR/PIK3R2/VDAC3/CCNA2/ANAPC4/KAT2B/ANAPC16/ADCY6/ATF4/MAP2K4/ATR	4.7817703544602
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	39/1738	105/9376	2.00374815058359	JUN/BNIP3/CCZ1/TBK1/CITED2/EIF2AK3/GABARAPL1/SMURF2/RABGEF1/MAP1LC3C/SIAH1/MAPK8/AMFR/ULK1/MTX2/EIF2S1/CALCOCO2/RRAS2/MAP1LC3B/RAB5A/USP15/TBC1D15/RHOT1/ARIH1/CSNK2A2/RELA/CSNK2B/MAPK9/CCZ1B/GABARAPL2/CSNK2A1/SMURF1/MFN1/USP30/RRAS/MTX3/BNIP3L/MFN2/ATF4	4.93374630703882
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	52/1738	156/9376	1.79823551975451	IFIT1/MX2/MX1/OAS2/OAS1/IRF7/OAS3/SOCS3/STAT1/NFKBIA/EIF2AK2/STAT2/FAS/MYC/IRF9/TBK1/AKT1/CTNNB1/CYCS/PPP2CB/CLDN23/RAF1/PPP2R2D/SOS2/TRAF6/PPP2R1B/EIF2S1/CDKN1A/BRAF/STAT3/CASP3/SOS1/MAP2K1/RNASEL/PIK3CA/YWHAQ/RSAD2/RELA/YWHAG/APAF1/RB1/ARAF/AKT3/OCLN/PPARA/CDK2/PIK3R2/CLDN12/PPP2CA/CLDN15/TICAM1/LDLR	4.79566220603713
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	27/1738	63/9376	2.31201709682722	GADD45A/PTCH2/WNT4/WNT5A/BMP2/CTNNB1/GADD45B/POLK/GADD45G/DVL1/WNT6/AXIN2/CDKN1A/GLI2/FZD7/FZD2/AXIN1/WNT9A/WNT2B/KIF7/FZD6/FZD1/TCF7L2/WNT10A/WNT11/WNT7B/GLI3	4.98408757684798
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	59/1738	187/9376	1.70207319249491	OAS2/OAS1/IRF7/OAS3/STAT1/NFKBIA/JUN/STAT2/NEK7/TXN/IRF9/GBP1/TBK1/NLRP1/NOD1/GABARAPL1/TANK/PLCB1/MAP1LC3C/MAPK8/TRAF6/SUGT1/ATG12/ANTXR1/TRPM7/MAPK14/CASP1/PRKCD/MAP1LC3B/RNASEL/GBP3/IL6/ATG5/ERBIN/TAB3/MAP3K7/VDAC2/RELA/BIRC2/TRIP6/MAPK9/PLCB3/MCU/GABARAPL2/MFN1/ATG16L1/PKN2/VDAC1/CASP4/IRAK4/CXCL1/SHARPIN/VDAC3/MFN2/TICAM1/MYD88/ITPR3/TAB2/IFI16	4.62583103255528
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	39/1738	108/9376	1.94808847973405	EIF4A3/NXT1/NUP160/THOC3/DDX39B/NUP58/NUP98/NUP153/NXF1/XPO4/XPOT/SUMO1/RNPS1/NUP54/KPNA5/RANBP17/NUP155/SUMO4/KPNA4/THOC1/NMD3/MAGOHB/CSE1L/XPO1/ALYREF/THOC7/MAGOH/THOC6/NUP188/NUP107/TNPO3/UPF1/SEC13/UBE2I/ACIN1/SUMO2/NUP205/NUP88/IPO7	4.72703079832306
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	30/1738	75/9376	2.15788262370541	IGFBP3/SERPINE1/FAS/GADD45A/RCHY1/THBS1/BBC3/PPP1R13L/CYCS/GADD45B/GADD45G/SIAH1/PPM1D/MDM4/CDKN1A/CASP3/SESN1/MDM2/RRM2B/CCNG1/CCND3/CCNG2/CDKN2A/COP1/PTEN/APAF1/GORAB/CDK2/SHISA5/ATR	4.80231942083422
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	74/1738	250/9376	1.596833141542	ARF4/RAB11FIP3/HSPA1B/ARF1/GRK5/CHMP5/IGF1R/SMURF2/SPART/WASHC1/PML/ITCH/PDCD6IP/TRAF6/RUFY2/SNX3/ARAP1/NEDD4/CBLB/PLD1/SMAD2/ARFGAP3/EPN2/SMAD3/MDM2/TSG101/TGFBR1/CYTH2/LDLRAP1/FGFR2/ZFYVE9/RAB5A/EPS15L1/TFRC/VPS29/STAM2/WASHC4/ARFGEF1/CAPZA2/PARD3/VPS37A/FGFR4/HLA-F/CAPZA1/RAB8A/ARPC1A/CAV2/FGFR3/WASHC2A/PIP5K1A/HSPA8/SMURF1/IST1/AGAP1/CHMP4B/ASAP2/PARD6G/GBF1/AP2A1/CHMP7/STAM/AGAP4/WASHC3/EPS15/VPS26A/RAB11A/RAB11FIP5/ASAP3/PRKCI/ARFGAP1/AGAP6/ASAP1/ARAP3/LDLR	4.56250549397441
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	37/1738	101/9376	1.97627864052228	SERPINE1/EGR1/STAT1/JUN/VEGFA/PIM1/STAT5B/PLCG2/AKT1/SMAD4/PRKCE/F3/PLCB1/TGFB2/MAPK8/TGFB3/STAT3/CASP3/MAPK14/SMAD2/SMAD3/TGFBR1/PRKCD/FOXO1/PIK3CA/IL6/COL4A6/RELA/IL1A/MAPK9/PLCB3/PRKCA/COL4A1/AKT3/VEGFB/PIK3R2/JAK2	4.70541803480721
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	31/1738	80/9376	2.09044879171461	VEGFA/PDGFA/AXL/PLCG2/AKT1/IGF1R/SHC2/RAF1/SOS2/FGF2/EIF4E/BRAF/PDGFRB/STAT3/SOS1/RPS6KB1/MAP2K1/FGFR2/PIK3CA/IL6/GAS6/FGFR3/PRKCA/PTEN/ARAF/AKT3/BCL2L11/NF1/PIK3R2/NRG2/JAK2	4.67221596222815
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	42/1738	122/9376	1.8571940613858	SOCS1/IGFBP3/SOCS3/JUNB/IRS2/STAT1/FOS/STAT5B/PLCG2/ADCY9/AKT1/PTK2/GNAI1/PLCB1/SHC2/MAPK8/ATF2/RAF1/IRS1/SOS2/BCAR1/STAT3/MAPK14/SOS1/MAP2K1/PIK3CA/MAPK9/CRKL/PLCB3/PRKCA/CREB3L2/AKT3/PIK3R2/GNAI3/GNA11/SOCS2/SSTR2/JAK2/ADCY6/ITPR3/ATF4/MAP2K4	4.54584913582864
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	34/1738	93/9376	1.97225831198881	NFKBIA/MYC/GADD45A/AKT1/PTK2/CYCS/GADD45B/POLK/GADD45G/TRAF6/CDKN1A/CASP3/ITGA3/PIK3CA/RARB/COL4A6/TRAF4/LAMA5/CKS2/RELA/CKS1B/BIRC2/COL4A1/ITGAV/MAX/PTEN/APAF1/RB1/CDKN2B/AKT3/RXRB/CDK2/PIK3R2/LAMC3	4.49468914391856
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	124/1738	480/9376	1.39363252780974	COX7A1/PSMA2/XBP1/FAS/DKK1/TUBB2A/WNT4/ATXN2L/TUBB4B/TBK1/PSMD9/PPP3CC/EIF2AK3/WNT5A/CSNK1E/TANK/CTNNB1/PLCB1/CYCS/DVL1/MAP1LC3C/SDHB/UCHL1/MAPK8/NDUFA7/RAF1/NDUFC2/SDHD/ULK1/SDHA/ERN1/UBE2L6/CAMK2D/WNT6/PSMA3/AXIN2/CASP7/KLC1/EIF2S1/BRAF/CASP3/MAPK14/RAB1A/NDUFS4/ATXN1/SPG11/FZD7/DLG4/ACTR10/DCTN6/MAP1LC3B/PSMD11/FZD2/MAP2K1/TARDBP/NDUFA13/ATXN1L/RAB5A/DERL1/IL6/NDUFA5/PSMC6/AXIN1/PRNP/NDUFB3/UBE2J2/WNT9A/NDUFB5/CSNK2A2/PPID/RAB8A/VDAC2/RELA/PPP3CB/CSNK2B/CSNK1A1/IL1A/MAPK9/TRAP1/PLCB3/MCU/PSEN1/CSNK2A1/NEFM/WNT2B/MFN1/PSMA1/PPP3R1/PRKCA/CSF1/KLC2/CALM2/GPX8/VDAC1/ATP2A2/PSMB2/KLC4/FZD6/APAF1/FZD1/CAPN2/ARAF/SNCAIP/UBE2G1/COX7A2L/IFT57/ATXN3/ATG101/PSMA5/WNT10A/WNT11/NDUFV3/VDAC3/MAPT/DDIT3/ATG2B/MFN2/TUBB2B/ATG13/ITPR3/ATF4/HSPA5/NDUFB8/WNT7B	4.22313444880971
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	50/1738	157/9376	1.71805941377819	SOCS3/COX7A1/IRS2/JUN/FOS/XBP1/FAS/AKT1/EIF2AK3/INSR/CYCS/SDHB/MAPK8/NDUFA7/NDUFC2/IRS1/SDHD/SDHA/ERN1/ITCH/ADIPOR1/CASP7/EIF2S1/CASP3/MAPK14/NDUFS4/LEPR/NDUFA13/PIK3CA/IL6/NDUFA5/NDUFB3/NDUFB5/PRKAA1/RELA/IL1A/MAPK9/PRKAG2/AKT3/COX7A2L/PPARA/MLX/BCL2L11/PIK3R2/PRKAB1/NDUFV3/DDIT3/ATF4/NDUFB8/PRKAB2	4.32801738044843
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	49/1738	155/9376	1.70542336389621	RASD1/WNT4/ADCY9/AHR/NR4A1/WNT5A/GNAI1/CTNNB1/PLCB1/DVL1/PDE8A/ATF2/CAMK2D/WNT6/RAP1B/AXIN2/ARNT/CDKN1A/BRAF/FZD7/FZD2/MAP2K1/WDR5/AXIN1/WNT9A/PBX1/RBBP5/PLCB3/WNT2B/CDKN2A/CREB3L2/FZD6/RB1/FZD1/CDKN2B/TCF7L2/WNT10A/WNT11/CDK2/GNAI3/RAP1A/GNA11/ADCY6/ITPR3/ATF4/WNT7B/FH/LDLR/KCNK3	4.22422823303638
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	40/1738	119/9376	1.81334674260959	SOCS3/CEBPB/JUNB/NFKBIA/JUN/FOS/FAS/IL18R1/AKT1/IRF1/MAPK8/ATF2/RHBDF1/ITCH/CASP7/MAP3K8/IL15/MMP14/CASP10/CASP3/MAPK14/MAP2K1/PIK3CA/IL6/TAB3/MAP3K7/RELA/LIF/BIRC2/MAPK9/BAG4/CSF1/CREB3L2/AKT3/CXCL1/PIK3R2/ATF4/MAP2K4/TAB2/ADAM17	4.25926613975163
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	63/1738	214/9376	1.58816127679253	NFKBIA/JUN/FOS/WEE1/FAS/SKP1/PLCG2/TAP2/TBK1/PPP3CC/AKT1/TAP1/PTK2/GNAI1/B2M/BST2/CYCS/MAPK8/AP1G1/RAF1/CFL2/TRAF6/ELOC/CGAS/GNG4/CASP3/MAPK14/GNB5/CUL4A/RPS6KB1/TRIM5/MAP2K1/PIK3CA/BTRC/GNG5/GNGT1/MAP3K7/HLA-F/RELA/PPP3CB/PXN/MAPK9/CRKL/PPP3R1/GNG12/PRKCA/CUL1/CALM2/CUL5/LIMK1/AKT3/IRAK4/GNB2/CALR/PIK3R2/GNAI3/GNA11/RNF7/MYD88/PAK4/ITPR3/TAB2/ATR	4.15172776407556
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	66/1738	227/9376	1.56850499079909	NFKBIA/VEGFA/FAS/MYC/PTGER2/IL10RB/ARHGEF11/RHEB/ADCY9/TAP2/IL1R1/TBK1/PPP3CC/AKT1/TAP1/PTK2/GNAI1/B2M/CTNNB1/PLCB1/CYCS/ATF2/RAF1/SOS2/BCAR1/CGAS/GNG4/CDKN1A/GNA12/STAT3/CASP3/MAPK14/SOS1/GNB5/MDM2/RPS6KB1/MAP2K1/TSC1/PIK3CA/IL6/ARHGEF12/GNG5/GNGT1/HLA-F/RELA/PPP3CB/PXN/CRKL/PLCB3/PPP3R1/GNG12/PRKCA/CDKN2A/CALM2/ITGAV/CREB3L2/RB1/AKT3/GNB2/CALR/PIK3R2/GNAI3/GNA11/ADCY6/ITPR3/ATF4	4.13600536726661
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	37/1738	109/9376	1.83123066690597	SOCS3/IRS2/NFKBIA/GFPT2/TRIB3/PPP1CB/AKT1/OGT/CRTC2/PRKCE/INSR/MAPK8/IRS1/PPP1R3B/STAT3/RPS6KB1/PRKCD/PPP1R3C/FOXO1/GFPT1/PIK3CA/IL6/PRKAA1/RELA/MAPK9/PRKAG2/NR1H2/CPT1B/PTEN/CREB3L2/AKT3/PPARA/MLX/PIK3R2/PRKAB1/ACACB/PRKAB2	4.16376223767351
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	31/1738	86/9376	1.94460352717639	JUN/MYC/STAT5B/PLCG2/AKT1/ABL1/PTK2/NCK1/SHC2/MAPK8/RAF1/SOS2/CAMK2D/BTC/CDKN1A/BRAF/CBLB/SOS1/RPS6KB1/MAP2K1/PIK3CA/NCK2/MAPK9/CRKL/PRKCA/ARAF/AKT3/PIK3R2/NRG2/PAK4/MAP2K4	4.19770223709624
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	32/1738	90/9376	1.91811788773814	IRS2/SIRT1/RHEB/ADCY9/AKT1/IGF1R/INSR/SOD2/ATF2/IRS1/ULK1/ADIPOR1/EIF4E/SESN1/RPS6KB1/FOXO1/TSC1/PIK3CA/ATG5/PRKAA1/RELA/PRKAG2/CREB3L2/AKT3/ATG101/PIK3R2/PRKAB1/ATG13/EHMT1/ADCY6/ATF4/PRKAB2	4.17470758664623
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	70/1738	248/9376	1.52269943205019	RHOB/NFKBIA/JUN/FOS/MYC/TXN/AHNAK2/TUBB2A/SKP1/TUBB4B/ARF1/AKT1/RAB9A/NOD1/CTNNB1/CYCS/MAPK8/ELMO1/RAF1/TRAF6/DYNLL1/NCKAP1/CASP7/KLC1/DYNLT3/EXOC5/CASP3/MAPK14/CASP1/DYNC2LI1/ACTR10/DCTN6/ARHGEF26/MAP2K1/CYTH2/RAB5A/PIK3CA/KPNA4/IL6/TAB3/MAP3K7/ACTB/RELA/ARPC1A/CSE1L/ABI1/BIRC2/DYNC1I1/MAPK9/ARL8A/RALA/DYNC2H1/SNX9/RRAS/KLC2/MYO6/KLC4/CASP4/SNX33/AKT3/IRAK4/TCF7L2/ARL8B/TUBB2B/MYD88/MAP2K4/TAB2/DYNLT1/MYL12B/ACBD3	3.97933727621476
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	35/1738	103/9376	1.83315271431285	SERPINE1/NFKBIA/JUN/FOS/FAS/AKT1/GNAI1/IFNGR2/PLCB1/TGFB2/MAPK8/PPP2CB/IFNGR1/PPP2R2D/TRAF6/TGFB3/PPP2R1B/MAPK14/SMAD2/TGFBR1/PIK3CA/IL6/RELA/MAPK9/PLCB3/AKT3/IRAK4/CALR/PIK3R2/GNAI3/GNA11/PPP2CA/TICAM1/MYD88/MAP2K4	4.05558766266863
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	52/1738	173/9376	1.62153029526996	MX2/MX1/OAS2/OAS1/IRF7/OAS3/SOCS3/STAT1/NFKBIA/EIF2AK2/IFIH1/STAT2/FAS/IRF9/TBK1/NXT1/AKT1/IFNGR2/CYCS/ADAR/TRIM25/NUP98/IFNGR1/RAF1/PABPN1/PML/NXF1/EIF2S1/CASP3/CASP1/CALCOCO2/KPNA5/MAP2K1/RNASEL/PIK3CA/IL6/RSAD2/ACTB/RELA/XPO1/IL1A/CCND3/PRKCA/VDAC1/APAF1/AKT3/IRAK4/PIK3R2/RAB11A/TICAM1/MYD88/JAK2	3.93587538925766
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	24/1738	62/9376	2.08827350681169	HES1/DLL4/TLE4/MAML2/DTX3L/CTBP2/TLE2/DVL1/ITCH/HEYL/TLE1/DTX3/ATXN1/MAML1/CTBP1/ATXN1L/NUMBL/NOTCH2/PSEN1/KAT2A/NCSTN/SPEN/KAT2B/ADAM17	4.1009689578431
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	61/1738	212/9376	1.55225047224092	VEGFA/ID1/PDGFA/F2R/ADCY9/THBS1/AKT1/GNAI1/IGF1R/INSR/PRKD3/CTNNB1/PLCB1/RAF1/FGF2/RAP1B/BCAR1/VAV2/BRAF/PDGFRB/MAPK14/MAP2K1/FGFR2/PIK3CA/LPAR1/PARD3/FGFR4/ACTB/FGFR3/CRKL/PLCB3/RALA/ADORA2B/PRKCA/CSF1/RRAS/CALM2/CNR1/AFDN/PARD6G/RAPGEF2/AKT3/FGF22/FGF10/EPHA2/RAPGEF3/RALB/VEGFB/FARP2/MAGI2/PIK3R2/GNAI3/RAP1A/RAP1GAP/MAGI3/PRKCI/ADCY6/KITLG/MAGI1/ARAP3/PRKD1	3.87955741344033
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	26/1738	70/9376	2.00374815058359	JUN/VEGFA/FLCN/AKT1/EGLN3/TGFB2/RAF1/SOS2/EGLN1/TGFB3/RAP1B/ELOC/ARNT/CDKN1A/BRAF/SOS1/MAP2K1/PIK3CA/CRKL/ARAF/AKT3/PIK3R2/RAP1A/PAK4/CUL2/FH	4.0208044438894
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	23/1738	59/9376	2.10302120106883	MYC/GADD45A/AKT1/CTNNB1/GADD45B/POLK/GADD45G/RAF1/SOS2/AXIN2/CDKN1A/BRAF/SOS1/MAP2K1/PIK3CA/AXIN1/MLH1/PTEN/ARAF/AKT3/TCF7L2/PIK3R2/ILK	4.0540818754148
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	48/1738	158/9376	1.6388981952193	WEE1/MYC/GADD45A/CDKN1C/SKP1/ABL1/SMAD4/GADD45B/GADD45G/CCNH/TGFB2/ORC4/PPP2CB/TGFB3/PPP2R1B/CDKN1A/CDKN2D/SMAD2/SMAD3/MDM2/ORC2/ANAPC10/YWHAQ/CDC16/STAG1/PDS5A/CDC26/ANAPC1/MAU2/BUB3/MAD2L1BP/CCND3/ORC3/YWHAG/CDKN2A/CUL1/RB1/CDKN2B/RBL1/E2F5/CDK2/PPP2CA/CCNA2/ANAPC4/RBL2/ANAPC16/ATR/TFDP1	3.86333661495091
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	43/1738	138/9376	1.6809592902053	SOCS1/SOCS3/IRS2/MKNK2/RHEB/PPP1CB/AKT1/INSR/SHC2/MAPK8/RAF1/IRS1/SOS2/EIF4E/PHKG1/RHOQ/BRAF/PPP1R3B/HK2/CBLB/SOS1/TRIP10/RPS6KB1/PPP1R3C/MAP2K1/FOXO1/TSC1/PIK3CA/PRKAA1/MAPK9/PRKAG2/CRKL/SORBS1/CALM2/ARAF/AKT3/PIK3R2/PRKAB1/ACACB/SOCS2/PPP1R3F/PRKCI/PRKAB2	3.84407994204226
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	41/1738	130/9376	1.70140745330619	NFKBIA/JUN/VEGFA/FOS/ADCY9/AKT1/GNAI1/RXFP1/PLCB1/SHC2/MAPK8/ATF2/RAF1/SOS2/GNG4/MAPK14/SMAD2/SOS1/GNB5/TGFBR1/MAP2K1/PIK3CA/GNG5/GNGT1/COL4A6/RELA/MAPK9/PLCB3/GNG12/PRKCA/COL4A1/CREB3L2/AKT3/GNB2/EDNRB/VEGFB/PIK3R2/GNAI3/ADCY6/ATF4/MAP2K4	3.8413670367017
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	26/1738	71/9376	1.9755263456458	PRL/SOCS1/SOCS3/STAT1/FOS/STAT5B/AKT1/IRF1/SHC2/MAPK8/RAF1/SOS2/STAT3/MAPK14/SOS1/MAP2K1/PIK3CA/RELA/CISH/MAPK9/AKT3/ESR2/PIK3R2/SOCS2/SOCS5/JAK2	3.93577883164188
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	34/1738	103/9376	1.78077692247534	EIF4A3/DAZAP1/PPP1CB/NXT1/MSI2/DDX39B/SMG1/PELO/PPP2CB/PABPN1/PPP2R2D/NXF1/PPP2R1B/PAPOLA/RNPS1/WDR33/PCF11/TARDBP/CPSF6/MAGOHB/CPSF7/PPP2R3C/SMG7/ALYREF/MAGOH/RNMT/UPF1/PPP2R3A/PPP2CA/ACIN1/CSTF1/PAPOLG/NUDT21/FIP1L1	3.80063486524073
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	44/1738	144/9376	1.64838255977497	PSMA2/XBP1/ATXN2L/PSMD9/AKT1/PLCB1/CYCS/GTF2B/MAPK8/TBPL1/ULK1/ERN1/OMA1/PSMA3/MYOD1/ATXN1/PSMD11/ATXN1L/PIK3CA/PSMC6/PUM2/ATXN10/VDAC2/NFYA/MAPK9/PLCB3/MCU/CACNA1A/PSMA1/PRKCA/VDAC1/ATP2A2/PSMB2/PUM1/AKT3/ATXN3/ATG101/PSMA5/PIK3R2/VDAC3/NOP56/ATG2B/ATG13/ITPR3	3.74011856593917
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/1738	76/9376	1.91654048815941	GADD45A/PDGFA/PLCG2/AKT1/IGF1R/GADD45B/POLK/SHC2/GADD45G/RAF1/SOS2/CAMK2D/CDKN1A/BRAF/PDGFRB/SOS1/MDM2/MAP2K1/PIK3CA/PRKCA/CDKN2A/CALM2/PTEN/RB1/ARAF/AKT3/PIK3R2	3.82681681669928
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	58/1738	205/9376	1.52630722164529	ISG15/OAS2/OAS1/IRF7/OAS3/STAT1/NFKBIA/JUN/HES1/EIF2AK2/SAP30/VIM/STAT2/FAS/MYC/GADD45A/IRF9/PLCG2/TAP2/TBK1/AKT1/TAP1/B2M/CYCS/GADD45B/POLK/GADD45G/MAPK8/TRAF6/CDKN1A/NEDD4/STAT3/CASP3/MAPK14/MDM2/PSMD11/PIK3CA/IL6/PSMC6/MAP3K7/HLA-F/RELA/MAPK9/CCND3/APAF1/RB1/AKT3/IRAK4/BCL2L11/CDK2/SIN3A/CALR/PIK3R2/CCNA2/MYD88/MAP2K4/TAB2/CD58	3.63436557544268
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	38/1738	122/9376	1.68031843649192	IRS2/SIRT1/RHEB/AKT1/PFKP/CRTC2/IGF1R/INSR/PPP2CB/CAB39L/IRS1/ULK1/PPP2R2D/ADIPOR1/PPP2R1B/LEPR/RPS6KB1/FOXO1/TSC1/PIK3CA/EEF2K/PRKAA1/MAP3K7/RAB8A/PPP2R3C/PRKAG2/ELAVL1/CAB39/CPT1B/CREB3L2/AKT3/PPP2R3A/PIK3R2/PRKAB1/PPP2CA/CCNA2/ACACB/PRKAB2	3.60784694613412
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	57/1738	203/9376	1.51476982205922	JUN/VEGFA/PDGFA/EMP1/PPP1CB/THBS1/AKT1/PTK2/ITGA1/IGF1R/CTNNB1/ITGB8/SHC2/EMP2/MAPK8/RAF1/COL6A3/SOS2/RAP1B/COL6A6/BCAR1/VAV2/BRAF/PDGFRB/SOS1/MAP2K1/FYN/ITGA3/PIK3CA/COL4A6/ACTB/LAMA5/CAV2/PXN/BIRC2/MAPK9/CCND3/CRKL/PIP5K1A/PPP1R12B/ITGA11/PRKCA/THBS2/COL4A1/ITGAV/PARVA/PTEN/CAPN2/AKT3/VEGFB/PIK3R2/TNC/RAP1A/LAMC3/PAK4/ILK/MYL12B	3.53692701580123
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	35/1738	110/9376	1.71649754158385	SERPINE1/VEGFA/LDHA/ALDOA/MKNK2/PLCG2/AKT1/PFKP/EGLN3/ENO2/IFNGR2/IGF1R/INSR/IFNGR1/CAMK2D/EGLN1/ELOC/EIF4E/ARNT/CDKN1A/HK2/STAT3/RPS6KB1/MAP2K1/PIK3CA/IL6/TFRC/RELA/PDK1/PRKCA/TIMP1/AKT3/PIK3R2/PGK1/CUL2	3.6056668451517
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	55/1738	196/9376	1.51382071816068	ZFP36/IRF7/STAT1/NFKBIA/JUN/VEGFA/EIF2AK2/FOS/STAT2/FAS/MYC/IRF9/PLCG2/TBK1/PPP3CC/AKT1/CTNNB1/CYCS/MAP1LC3C/MAPK8/IFNGR1/RAF1/FGF2/GNG4/CDKN1A/STAT3/CASP3/MAPK14/GNB5/MAP1LC3B/MAP2K1/PIK3CA/IL6/RCAN1/GNG5/GNGT1/HLA-F/RELA/PPP3CB/MAPK9/PPP3R1/GNG12/CALM2/RB1/AKT3/GNB2/TCF7L2/MICA/CXCL1/PIK3R2/TICAM1/JAK2/MAPKAPK2/ITPR3/MAP2K4	3.46767992393853
Organismal Systems	Nervous system	hsa04730	Long-term depression	22/1738	60/9376	1.97805907172996	PLA2G4A/GUCY1B1/GNAI1/IGF1R/PLCB1/PPP2CB/RAF1/PPP2R1B/BRAF/GNA12/PRKG1/MAP2K1/GUCY1A2/PLCB3/CACNA1A/PRKCA/ARAF/GUCY1A1/GNAI3/GNA11/PPP2CA/ITPR3	3.62532268109217
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	59/1738	216/9376	1.4735541064655	IRF7/NFKBIA/JUN/FOS/XBP1/FAS/HSPA1B/HSPA2/ERO1A/TBK1/PPP3CC/AKT1/EIF2AK3/PTK2/TANK/PLCB1/CYCS/MAPK8/SOD2/ERN1/CAMK2D/TRAF6/RAP1B/CASP7/EIF2S1/VAV2/STAT3/CASP3/MAPK14/CASP1/PIK3CA/IL6/ABCA1/MAP3K7/RELA/PPP3CB/MAPK9/HSPA8/PLCB3/PPP3R1/PRKCA/CALM2/APAF1/AKT3/IRAK4/RXRB/CXCL1/PIK3R2/RAP1A/DDIT3/TICAM1/MYD88/MIB2/JAK2/ATF4/MAP2K4/TAB2/HSPA5/LDLR	3.35868630128543
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	33/1738	105/9376	1.69547920433996	STAT1/NFKBIA/JUN/KSR1/STAT2/IRF9/PLCG2/PPP3CC/AKT1/IRF1/MAPK8/RAF1/BCL10/CBLB/MAPK14/CASP1/MDM2/PRKCD/RRAS2/PIK3CA/IL6/ARHGEF12/RELA/PLK3/PPP3CB/MAPK9/PPP3R1/RRAS/CALM2/AKT3/PIK3R2/MAPKAPK2/ITPR3	3.41850488495503
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	67/1738	253/9376	1.42863770541761	NFKBIA/JUN/BNIP3/UBE2V1/SKP1/PLCG2/IL1R1/TBK1/ARF1/AKT1/PTK2/PRKCE/NOD1/PLCB1/CYCS/MAP1LC3C/UBE2D1/MAPK8/UBE2N/ELMO1/TRAF6/CTTN/BCAR1/ATG12/CGAS/GLMN/BCL10/HK2/MAPK14/CASP1/MDM2/CALCOCO2/RPS6KB1/PRKCD/MAP1LC3B/CYTH2/FOXO1/UBE2V2/PIK3CA/BTRC/TNIP1/ATG5/WASF1/TAB3/MAP3K7/PPID/ACTB/RELA/ARPC1A/PXN/MAPK9/CRKL/PLCB3/UBE2D3/ATG16L1/CUL1/VDAC1/CASP4/CAPN2/AKT3/SHARPIN/PIK3R2/MYD88/ILK/ITPR3/TAB2/MYL12B	3.29687507960187
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	13/1738	29/9376	2.41831673346296	LATS2/TEAD1/CSNK1E/SAV1/WTIP/FRMD6/STK3/YAP1/AJUBA/TEAD3/WWTR1/LATS1/MOB1A	3.64885664779765
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	37/1738	122/9376	1.63609953026844	STAT1/MYC/RHEB/WNT4/PLCG2/AKT1/THRB/PFKP/CTNNB1/PLCB1/MED30/MED13L/RAF1/GATA4/MDM2/ATP1B1/MAP2K1/FOXO1/PIK3CA/RCAN1/NOTCH2/NCOA3/NCOA2/ACTB/MED17/PLCB3/PRKCA/KAT2A/ITGAV/ATP2A2/MED13/AKT3/RXRB/SIN3A/PIK3R2/KAT2B/NCOA1	3.37334639871049
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	22/1738	62/9376	1.91425071457738	IRS2/CRYAB/SIRT1/HSPA1B/ADCY9/AKT1/IGF1R/INSR/SOD2/IRS1/RPS6KB1/FOXO1/PIK3CA/ATG5/PRKAA1/PRKAG2/HSPA8/AKT3/PIK3R2/PRKAB1/ADCY6/PRKAB2	3.44519440811535
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	45/1738	157/9376	1.54625347240037	CEBPB/DUSP8/SIRT1/PTGER2/AXL/DUSP7/THBS1/EPOR/ODC1/PTK2/DUSP5/ELMO1/CAMK2D/BCAR1/CASP7/GULP1/ARNT/CASP3/MAPK14/CASP1/MAP2K1/RAB5A/ATP11A/GAS6/MFGE8/ABCA1/CD47/NR1H2/PBX1/CRKL/DUSP16/ADAM9/CPT1B/ITGAV/ATP2A2/VPS8/ATP11B/CALR/SLC16A1/PPARD/JAK2/MAPKAPK2/PROS1/TGFBRAP1/ADAM17	3.29247758237652
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	29/1738	90/9376	1.73829433576269	STAT1/NFKBIA/JUN/FOS/PPP3CC/AKT1/IFNGR2/IFNGR1/RAF1/TRAF6/BATF3/STAT3/BATF2/MAPK14/RPS6KB1/MAP2K1/PIK3CA/CSNK2A2/RELA/PPP3CB/CSNK2B/CSNK2A1/PPP3R1/PTEN/AKT3/PIK3R2/TICAM1/MYD88/JAK2	3.35704489134789
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	90/1738	362/9376	1.3412253876622	PRL/VEGFA/DDIT4/MYC/PDGFA/F2R/RHEB/THBS1/EPOR/NR4A1/AKT1/PTK2/CRTC2/ITGA1/IGF1R/INSR/ITGB8/CSF3/PPP2CB/ATF2/RAF1/IRS1/PPP2R2D/COL6A3/SOS2/FGF2/PPP2R1B/COL6A6/EIF4E/GNG4/GDNF/CDKN1A/PDGFRB/OSMR/SOS1/GNB5/MDM2/RPS6KB1/IL4R/MAP2K1/FGFR2/ITGA3/TSC1/PIK3CA/IL6/YWHAQ/LPAR1/PHLPP2/GNG5/GNGT1/FGFR4/PRKAA1/COL4A6/LAMA5/RELA/PPP2R3C/FGFR3/CCND3/ITGA11/YWHAG/RET/GNG12/PRKCA/THBS2/PKN2/COL4A1/CSF1/ITGAV/MCL1/PTEN/CREB3L2/AKT3/FGF22/FGF10/GNB2/EPHA2/BCL2L11/CDK2/VEGFB/PPP2R3A/MAGI2/PIK3R2/TNC/PPP2CA/LAMC3/RBL2/JAK2/ATF4/KITLG/MAGI1	3.15833026114696
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	41/1738	142/9376	1.55762654175919	SOCS1/SOCS3/JUNB/STAT1/NFKBIA/JUN/FOS/JUND/STAT2/IRF9/FOSB/PLCG2/FOSL2/IL1R1/PPP3CC/AKT1/IFNGR2/FHL2/TGFB2/MAPK8/IFNGR1/TRAF6/TMEM64/MAPK14/TGFBR1/MAP2K1/FYN/PIK3CA/MAP3K7/RELA/PPP3CB/IL1A/MAPK9/PPP3R1/CSF1/ATP2A2/AKT3/PIK3R2/GAB2/ITPR3/TAB2	3.19384158550022
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	20/1738	56/9376	1.92668091402269	NFKBIA/BNIP3/CLK1/SEC22B/HSPA1B/ARF1/CLK4/SAR1B/CYCS/CASP7/CASP3/RAB1A/CASP1/IL6/SAR1A/RELA/HSPA8/APAF1/CXCL1/MYD88	3.31769893157
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/1738	34/9376	2.22134975969674	BHLHE40/RORB/NFIL3/SKP1/CSNK1E/CRY1/FBXL3/PER1/BTRC/PRKAA1/PRKAG2/CUL1/PRKAB1/PRKAB2	3.40314360379109
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	54/1738	200/9376	1.45657077100115	NFKBIA/JUN/FOS/FAS/TUBB2A/F2R/ARHGEF11/SEC24D/IL1R1/TUBB4B/SEC24A/ARF1/ABL1/CYCS/NCK1/MAPK8/CLDN23/BAIAP2/TRAF6/CTTN/NCKAP1/CASP7/GNA12/CASP3/MAPK14/RAB1A/CASP1/CYTH2/FYN/IL6/SEC24C/ARHGEF12/NCK2/LPAR1/WASF1/TAB3/MAP3K7/ACTB/RELA/ARPC1A/ABI1/MAPK9/BAIAP2L1/SEC24B/MYO6/CASP4/OCLN/IRAK4/CLDN12/CLDN15/TUBB2B/MYD88/TMBIM6/TAB2	3.11327222962437
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	24/1738	73/9376	1.7736021564702	GADD45A/STAT5B/PLCG2/AKT1/GADD45B/POLK/GADD45G/RAF1/SOS2/CDKN1A/BRAF/STAT3/SOS1/MAP2K1/PIK3CA/RARB/RET/PRKCA/CDKN2A/RB1/ARAF/AKT3/RXRB/PIK3R2	3.1651062136874
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	32/1738	107/9376	1.61337018594797	LDHA/SIRT1/SIK1/PPP3CC/AKT1/PFKP/CRTC2/PLCB1/ATF2/CAMK2D/PHKG1/FOXO1/SIK2/PPP4C/PRKAA1/PPP4R3B/PPP3CB/PGAM1/PPP4R3A/PRKAG2/PLCB3/PPP3R1/CPT1B/CALM2/CREB3L2/AKT3/PPARA/PRKAB1/ACACB/ITPR3/ATF4/PRKAB2	3.04381888636932
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	25/1738	78/9376	1.72907261514856	PLCG2/IP6K3/MINPP1/PLCB1/MTMR3/MTMR2/IMPA1/INPP5E/PIK3CA/IMPA2/INPP1/PIP5K1A/PLCB3/ALDH6A1/PIKFYVE/ITPK1/IP6K1/PTEN/PPIP5K2/ITPKA/PIP4K2C/IPMK/INPP5B/MTMR4/ITPKC	3.08421051572272
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	30/1738	99/9376	1.63475956341319	JUN/FOS/PLA2G4A/PDGFA/SLC22A3/RHEB/CHPT1/AKT1/SLC44A1/MAPK8/RAF1/SOS2/PDGFRB/PLD1/SOS1/RPS6KB1/MAP2K1/TSC1/PIK3CA/CHKA/CHKB/WASF1/PLPP3/MAPK9/PIP5K1A/PRKCA/PLPP1/AKT3/PIK3R2/DGKD	3.02861290808277
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	21/1738	63/9376	1.79823551975451	GTF2H2/GTF2H2C/POLD4/POLR2M/CCNH/POLR2C/POLR2J3/CUL4A/POLR2A/GTF2H5/POLR2K/RAD23B/RPA4/ERCC5/POLR2H/MNAT1/POLE4/RPA3/RAD23A/ERCC3/POLR2B	3.03233528513321
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	39/1738	140/9376	1.5028111129377	SERPINE1/EGR1/ADCY9/KLF2/AKT1/GNAI1/SMAD4/PRKCE/PLCB1/MAP1LC3C/RAF1/NRF1/GNG4/PLAT/MEF2D/SMAD2/GNB5/SMAD3/RPS6KB1/TGFBR1/RRAS2/MAP1LC3B/MAP2K1/GNG5/GNGT1/PRKAA1/PRKAG2/PLCB3/GNG12/RRAS/CALM2/AKT3/GNB2/GNAI3/PRKAB1/ADCY6/ITPR3/HDAC4/PRKAB2	2.85922031376462
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/1738	56/9376	1.83034686832155	GAS1/PTCH2/CSNK1E/SMURF2/GLI2/MOSMO/BOC/SPOP/BTRC/EVC2/SPOPL/CSNK1A1/SMURF1/CUL3/CUL1/KIF7/CSNK1G2/EFCAB7/GLI3	2.9728042049601
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	41/1738	149/9376	1.48444945590473	PLA2G4A/PDGFA/F2R/RHEB/PLCG2/ADCY9/ARF1/AKT1/INSR/PLCB1/SHC2/RAF1/SOS2/GNA12/PDGFRB/PLD1/SOS1/RRAS2/MAP2K1/CYTH2/FYN/TSC1/PIK3CA/LPAR1/PTGFR/PLPP3/PIP5K1A/PLCB3/RALA/PRKCA/RRAS/PLPP1/AKT3/RAPGEF3/RALB/PIK3R2/AGPAT1/ADCY6/GAB2/KITLG/DGKD	2.84336127068746
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	22/1738	68/9376	1.74534623976173	MYC/PIM1/RARA/STAT5B/AKT1/ZBTB16/RAF1/PML/SOS2/BRAF/STAT3/SOS1/RPS6KB1/MAP2K1/PIK3CA/RELA/ARAF/AKT3/TCF7L2/PIK3R2/CCNA2/PPARD	2.9424224880849
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	28/1738	93/9376	1.6242127275202	SMAD4/IGF1R/INSR/SMURF2/CTNNB1/BAIAP2/RAP1B/NECTIN3/SMAD3/TGFBR1/FYN/PARD3/WASF1/CSNK2A2/MAP3K7/ACTB/CSNK2B/CSNK2A1/SMURF1/SORBS1/ACP1/AFDN/FER/TCF7L2/NECTIN1/FARP2/RAP1A/MYL12B	2.88569625508444
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1738	37/9376	2.04124031972133	MYC/GADD45A/TFG/CTNNB1/GADD45B/POLK/GADD45G/CDKN1A/BRAF/MAP2K1/RET/CCDC6/TCF7L2/RXRB	3.02706919448857
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	29/1738	98/9376	1.59639275733308	PLCG2/IP6K3/PLCB1/MTMR3/MTMR2/IMPA1/INPP5E/PIK3CA/IMPA2/INPP1/PIP4P2/PIP5K1A/PLCB3/PIKFYVE/PRKCA/ITPK1/CALM2/IP6K1/PTEN/PPIP5K2/ITPKA/PIP4K2C/IPMK/PIK3R2/INPP5B/MTMR4/ITPR3/ITPKC/DGKD	2.83099375722228
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/1738	73/9376	1.69970206661727	GADD45A/PDGFA/AKT1/IGF1R/GADD45B/POLK/GADD45G/RAF1/FGF2/CDKN1A/BRAF/PDGFRB/MDM2/MAP2K1/PIK3CA/CDKN2A/PTEN/RB1/ARAF/AKT3/FGF22/FGF10/PIK3R2	2.86275230783378
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	34/1738	120/9376	1.52850019179133	NFKBIA/JUN/ZNF274/PLCG2/AKT1/ABL1/SHC2/MAPK8/RAF1/IRS1/SOS2/CAMK2D/TRAF6/RAP1B/BRAF/MAPK7/MAPK14/SOS1/PRKCD/MAP2K1/PIK3CA/IRAK3/FRS2/RELA/MAPK9/CRKL/PSEN1/CALM2/AKT3/IRAK4/PIK3R2/RAP1A/MAPKAPK2/ATF4	2.77935995899785
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	39/1738	142/9376	1.48164475923435	DUSP1/JUN/VEGFA/FOS/MGST1/PDGFA/TXN/GSTT2B/KLF2/IL1R1/AKT1/PTK2/GSTA1/CTNNB1/MAPK8/PLAT/SUMO1/MAPK7/MAPK14/BMPR1A/SUMO4/PIK3CA/SDC4/PRKAA1/MAP3K7/ACTB/RELA/CAV2/IL1A/MAPK9/ACVR2B/CALM2/ITGAV/AKT3/NPPC/PIK3R2/SDC2/MAP2K4/SUMO2	2.75865107967767
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	52/1738	201/9376	1.39564547801842	IGFBP3/CEBPB/NFKBIZ/MEIS1/DDX5/MYC/GADD45A/PDGFA/RARA/SS18L1/BMI1/BCL6/PTK2/IGF1R/WT1/KDM6A/RUNX2/ZBTB16/GADD45B/POLK/HOXA9/HOXA11/GADD45G/CDK14/PML/MLLT3/ETV7/PLAT/CDKN1A/SS18/HOXA10/MDM2/LDB1/MLF1/FOXO1/IL6/SUPT3H/RELA/CCNT2/BIRC2/AFF1/PBX1/ELK4/PBX3/MAX/CDK9/ATF1/RXRB/SIN3A/DDIT3/CCNA2/PLAU	2.70471740574803
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	60/1738	238/9376	1.36001005695719	VEGFA/PLA2G4A/KSR1/PDGFA/PLCG2/TBK1/AKT1/ABL1/PLA2G5/IGF1R/INSR/ETS2/RASA3/SHC2/MAPK8/RALGAPA1/RAF1/SOS2/FGF2/SYNGAP1/RAP1B/GNG4/PDGFRB/PLD1/SOS1/GNB5/RRAS2/MAP2K1/RASA2/FGFR2/RAB5A/PIK3CA/GNG5/GNGT1/FGFR4/RELA/FGFR3/MAPK9/RALA/SHOC2/GNG12/PRKCA/CSF1/RRAS/CALM2/AFDN/AKT3/FGF22/FGF10/GNB2/EPHA2/NF1/RALB/VEGFB/PIK3R2/RAP1A/RASAL2/PAK4/GAB2/KITLG	2.6834791912788
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	29/1738	99/9376	1.58026757796608	JUN/FOS/DLL4/ADCY9/AKT1/PTK2/IGF1R/SHC2/MAPK8/RAF1/SOS2/CDKN1A/BRAF/MAPK14/SOS1/MDM2/RPS6KB1/MAP2K1/PIK3CA/NOTCH2/NCOA3/MAPK9/CDKN2A/RB1/ARAF/AKT3/ESR2/PIK3R2/ADCY6	2.7686166196854
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	35/1738	125/9376	1.51051783659379	CERS2/AKT1/GNAI1/PRKCE/PLCB1/SPTLC1/MAPK8/PPP2CB/RAF1/PPP2R2D/PPP2R1B/DEGS1/CERS5/CERS6/GNA12/MAPK14/PLD1/SPTSSA/MAP2K1/FYN/PIK3CA/SGPL1/RELA/PPP2R3C/MAPK9/PLCB3/PRKCA/PTEN/S1PR3/AKT3/PPP2R3A/PIK3R2/GNAI3/PPP2CA/GAB2	2.74089427304932
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	87/1738	368/9376	1.27537899634763	COX7A1/PSMA2/XBP1/TUBB2A/ATXN2L/SRSF7/TUBB4B/TBK1/PSMD9/PPP3CC/NXT1/EIF2AK3/NUP160/ANG/HNRNPA2B1/TANK/CYCS/MAP1LC3C/SDHB/NUP58/NUP98/UBQLN1/NDUFA7/NDUFC2/NUP153/SDHD/ULK1/SDHA/ERN1/NXF1/SRSF3/PSMA3/KLC1/EIF2S1/CASP3/MAPK14/RAB1A/CASP1/NDUFS4/SPG11/NUP54/ACTR10/DCTN6/MAP1LC3B/NUP155/PSMD11/TARDBP/NDUFA13/RAB5A/DERL1/NDUFA5/PSMC6/NDUFB3/NDUFB5/RAB8A/ACTB/PPP3CB/ALYREF/MCU/NEFM/PSMA1/PPP3R1/KLC2/GPX8/NUP188/VDAC1/NUP107/PSMB2/KLC4/APAF1/COX7A2L/ATG101/PSMA5/SEC13/NDUFV3/DDIT3/ATG2B/TUBB2B/ATG13/NRG2/ITPR3/ATF4/HSPA5/NUP205/NDUFB8/NUP88/ANXA7	2.57075820488421
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	29/1738	101/9376	1.54897515067962	WNT4/ADCY9/WNT5A/GNAI1/CTNNB1/PLCB1/DVL1/RAF1/CAMK2D/WNT6/FZD7/FZD2/MAP2K1/WNT9A/PLCB3/WNT2B/PRKCA/CALM2/CREB3L2/FZD6/FZD1/TCF7L2/WNT10A/WNT11/EDNRB/GNAI3/ADCY6/KITLG/WNT7B	2.64592245231034
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	27/1738	93/9376	1.56620513010876	EGR1/JUN/PLA2G4A/ADCY9/PLCB1/MAPK8/RAF1/SOS2/CAMK2D/MMP14/MAPK7/MAPK14/PLD1/SOS1/PRKCD/MAP2K1/MAPK9/PLCB3/PRKCA/CALM2/MAP3K4/GNA11/MAP3K2/ADCY6/ITPR3/ATF4/MAP2K4	2.61753077361209
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	12/1738	32/9376	2.02301495972382	LDHA/SUCLA2/MCEE/SUCLG2/HIBCH/ECHDC1/ALDH6A1/PCCA/DLD/ACACB/ACOX3/ACSS2	2.76510263477663
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1738	72/9376	1.64838255977497	ISG15/IRF7/NFKBIA/IFIH1/DHX58/TBK1/AZI2/TANK/ADAR/TRIM25/MAPK8/TRAF6/ATG12/CASP10/MAPK14/DDX3X/ATG5/SIKE1/MAP3K7/RELA/MAPK9/ZNFX1	2.63441032149776
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/1738	89/9376	1.57598169147024	PDGFA/TUBB2A/ADCY9/TUBB4B/GUCY1B1/GNAI1/PLCB1/RAF1/SOS2/PDGFRB/HTR2B/MAPK7/SOS1/PRKG1/MAP2K1/LPAR1/GUCY1A2/PLCB3/PRKCA/GUCY1A1/GNAI3/GNA11/MAP3K2/TUBB2B/ADCY6/ITPR3	2.60427388915922
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/1738	44/9376	1.83910450883984	GTF2H2/GTF2H2C/GTF2B/CCNH/TBPL1/TAF13/GTF2A2/TAF4/TAF7/TAF8/GTF2H5/GTF2A1/MNAT1/ERCC3/TAF12	2.66118903387013
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	22/1738	73/9376	1.62580197676435	MX2/MX1/BST2/NUP153/PDCD6IP/ELL2/MLLT3/TSG101/TRIM5/CPSF6/SERINC5/XPO1/CPSF7/CCNT2/NELFCD/MDFIC/NELFA/KAT2A/CHMP4B/CDK9/TNPO3/KAT2B	2.56039840198016
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	31/1738	112/9376	1.49317770836758	SOCS1/STAT1/NFKBIA/IL10RB/HSPA1B/AKT1/GNAI1/IFNGR2/CYCS/TGFB2/MAPK8/IFNGR1/TRAF6/TGFB3/STAT3/CASP3/MAPK14/MAP3K7/LAMA5/RELA/BIRC2/MAPK9/HSPA8/AKT3/IRAK4/GNAI3/LAMC3/MYD88/JAK2/TAB2/LDLR	2.50457403334885
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	43/1738	166/9376	1.39742398824296	IRS2/ADRA2C/PPP1CB/ADCY9/PPP3CC/AKT1/GUCY1B1/GNAI1/PRKCE/INSR/PLCB1/ATF2/RAF1/IRS1/PDE3A/GATA4/MEF2D/GNA12/PRKG1/ATP2B4/ATP1B1/MAP2K1/GUCY1A2/KCNMA1/VDAC2/PPP3CB/PLCB3/KCNJ8/PPP3R1/CALM2/VDAC1/ATP2A2/CREB3L2/AKT3/NPPC/GUCY1A1/EDNRB/GNAI3/VDAC3/GNA11/ADCY6/ITPR3/ATF4	2.46433079104577
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	32/1738	117/9376	1.47547529826011	MORF4L2/EPC2/SS18L1/DPF2/BCL7B/ARID1B/MTA3/MEAF6/PHF10/GATAD2B/MBD2/BICRA/SS18/ARID2/MTA1/GATAD2A/TRRAP/ACTB/EPC1/INO80D/ING3/ACTR8/BCL7C/SMARCD3/CDK2AP2/MRGBP/INO80C/MTA2/ACTL6A/SMARCE1/CDK2AP1/ACTR5	2.46865014014635
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/1738	41/9376	1.84209492267535	VEGFA/MYC/THBS1/RAF1/CDKN1A/BRAF/MDM2/DAPK1/MAP2K1/TYMP/FGFR3/CDKN2A/RB1/ARAF	2.57760587703223
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	33/1738	122/9376	1.45922390537456	NFKBIA/JUN/FOS/PPP3CC/AKT1/NCK1/MAPK8/PPP2CB/RAF1/PPP2R2D/SOS2/PPP2R1B/MAP3K8/BCL10/VAV2/CBLB/MAPK14/SOS1/MAP2K1/FYN/PIK3CA/NCK2/MAP3K7/RELA/PPP3CB/PPP2R3C/MAPK9/PPP3R1/AKT3/PPP2R3A/PIK3R2/PPP2CA/PAK4	2.43534420901597
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	21/1738	70/9376	1.61841196777906	SOCS3/IRS2/NFKBIA/AKT1/MAPK8/IRS1/ADIPOR1/STAT3/LEPR/PRKAA1/RELA/MAPK9/PRKAG2/CPT1B/AKT3/PPARA/RXRB/PRKAB1/ACACB/JAK2/PRKAB2	2.47722856251812
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	43/1738	168/9376	1.38078798838292	PRL/SOCS1/SOCS3/STAT1/IL11/STAT2/MYC/PIM1/PDGFA/IL10RB/IRF9/STAT5B/IL15RA/EPOR/AKT1/IFNGR2/CLCF1/CSF3/IFNGR1/RAF1/SOS2/IL15/CDKN1A/PDGFRB/STAT3/OSMR/SOS1/LEPR/IL4R/PIK3CA/IL6/STAM2/LIF/CISH/CCND3/PIAS2/MCL1/STAM/AKT3/PIK3R2/SOCS2/SOCS5/JAK2	2.3756142586457
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1738	30/9376	1.97805907172996	DLST/SUCLA2/SDHB/SDHD/SDHA/IDH3A/SUCLG2/ACO1/DLD/DLAT/FH	2.55937263347848
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	64/1738	268/9376	1.28828813355547	COX7A1/DUSP1/PSMA2/XBP1/TXN/TUBB2A/SLC39A14/TUBB4B/PSMD9/EIF2AK3/MAOB/GNAI1/CYCS/SDHB/UCHL1/SLC39A13/MAPK8/NDUFA7/NDUFC2/SDHD/SDHA/ERN1/UBE2L6/CAMK2D/PSMA3/KLC1/EIF2S1/CASP3/NDUFS4/PSMD11/NDUFA13/NDUFA5/PSMC6/NDUFB3/UBE2J2/NDUFB5/VDAC2/MAPK9/TRAP1/MCU/MFN1/PSMA1/SLC39A6/KLC2/CALM2/VDAC1/PSMB2/KLC4/APAF1/SNCAIP/UBE2G1/COX7A2L/PSMA5/GNAI3/NDUFV3/VDAC3/MAPT/DDIT3/MFN2/TUBB2B/ITPR3/ATF4/HSPA5/NDUFB8	2.284038129567
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	29/1738	106/9376	1.47591028508153	NFKBIA/PDGFA/NKX3-1/AKT1/IGF1R/CTNNB1/RAF1/SOS2/PLAT/CDKN1A/BRAF/PDGFRB/SOS1/MDM2/MAP2K1/FOXO1/FGFR2/PIK3CA/RELA/PTEN/CREB3L2/RB1/ARAF/AKT3/TCF7L2/CDK2/PIK3R2/PLAU/ATF4	2.35049241142092
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	35/1738	133/9376	1.41965962085882	FOS/PPP1CB/COMT/PPP3CC/AKT1/MAOB/GNAI1/PLCB1/MAPK8/PPP2CB/ATF2/PPP2R2D/CAMK2D/PPP2R1B/GNG4/MAPK14/GNB5/GNG5/GNGT1/PPP3CB/PPP2R3C/MAPK9/PLCB3/CACNA1A/GNG12/PRKCA/CALM2/CREB3L2/AKT3/GNB2/PPP2R3A/GNAI3/PPP2CA/ITPR3/ATF4	2.32507638465169
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	31/1738	115/9376	1.45422524641017	EGR1/FOS/JUND/ARHGEF11/PDE4D/ADCY9/GNAI1/RUNX2/PLCB1/ATF2/RAF1/MEF2D/CDKN1A/BRAF/GNA12/MMP14/PLD1/MAP2K1/OXSR1/PLCB3/PRKCA/CREB3L2/ARAF/VDR/RXRB/PTH1R/GNAI3/GNA11/ADCY6/ITPR3/ATF4	2.3378247091225
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	36/1738	138/9376	1.40731475459048	NFKBIA/JUN/FOS/TBK1/AKT1/PTK2/MAPK8/ELMO1/BAIAP2/TRAF6/BCAR1/VAV2/MAPK14/CASP1/MAP2K1/PIK3CA/IL6/ARHGEF12/MAP3K7/ACTB/RELA/ARPC1A/PXN/MAPK9/CRKL/PIP5K1A/PKN2/ARHGEF7/LIMK1/AKT3/IRAK4/PIK3R2/TICAM1/MYD88/MAP2K4/TAB2	2.29933051907859
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	27/1738	98/9376	1.48629670510321	PLA2G4A/PLCG2/AKT1/PRKCE/RAF1/CFL2/VAV2/PLD1/RPS6KB1/PRKCD/MAP2K1/PIK3CA/WASF1/ARPC1A/PLPP3/CRKL/PIP5K1A/MARCKSL1/PRKCA/ASAP2/PLPP1/LIMK1/AKT3/PIK3R2/ASAP3/GAB2/ASAP1	2.30838305693253
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	56/1738	232/9376	1.30217054878775	PDGFA/RGCC/F2R/PPP1CB/AKT1/PTK2/ITGA1/ITGB8/RAF1/CFL2/BAIAP2/SOS2/BDKRB1/FGF2/ARHGEF6/NCKAP1/BCAR1/DIAPH2/SPATA13/VAV2/BRAF/GNA12/PDGFRB/SOS1/RRAS2/MAP2K1/FGFR2/ITGA3/PIK3CA/ARHGEF12/LPAR1/WASF1/FGFR4/ACTB/ARPC1A/PXN/FGFR3/CRKL/PIP5K1A/PPP1R12B/ITGA11/PIKFYVE/GNG12/RRAS/ITGAV/ARHGEF7/ARAF/LIMK1/FGD1/AKT3/FGF22/FGF10/PIP4K2C/PIK3R2/PAK4/MYL12B	2.22304735625181
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	65/1738	275/9376	1.27511245946229	COX7A1/EGR1/PSMA2/TUBB2A/HSPA1B/TUBB4B/PSMD9/PPP3CC/EIF2AK3/CYCS/SDHB/MAPK8/ATF2/NDUFA7/NDUFC2/SDHD/SDHA/STIP1/PSMA3/KLC1/EIF2S1/NCAM2/CASP3/MAPK14/NDUFS4/PRKCD/PSMD11/FYN/NDUFA13/PIK3CA/IL6/NDUFA5/PSMC6/PRNP/NDUFB3/NDUFB5/CSNK2A2/VDAC2/PPP3CB/CSNK2B/CAV2/IL1A/MAPK9/HSPA8/MCU/CSNK2A1/PSMA1/PPP3R1/KLC2/VDAC1/PSMB2/CREB3L2/KLC4/APAF1/COX7A2L/PSMA5/PIK3R2/NDUFV3/VDAC3/DDIT3/TUBB2B/ITPR3/ATF4/HSPA5/NDUFB8	2.20878145044097
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	26/1738	94/9376	1.49215287809417	CEBPB/NFKBIA/JUN/FOS/JUND/FOSB/TBK1/USP25/CSF3/MAPK8/SRSF1/TRAF3IP2/TRAF6/MAPK6/MAPK7/CASP3/MAPK14/IL6/TAB3/MAP3K7/TRAF4/RELA/MAPK9/ELAVL1/CXCL1/TAB2	2.28751458190759
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	15/1738	47/9376	1.72171485933942	SOCS1/SOCS3/IRS2/MAFA/PRKCE/INSR/MAPK8/IRS1/HK2/PRKCD/PIK3CA/MAPK9/CACNA1A/PIK3R2/SOCS2	2.36601626985349
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	37/1738	144/9376	1.38613987981077	NFKBIA/TRA2A/FAS/SIRT1/TBK1/AKT1/LPIN1/CTNNB1/MAPK8/LPIN3/TRAF6/ADIPOR1/CASP3/MAPK14/FOXO1/IL6/TAB3/PRKAA1/MAP3K7/RELA/MAPK9/PRKAG2/CPT1B/ACADVL/AKT3/IRAK4/PPARA/TCF7L2/CXCL1/PRKAB1/ACACB/TICAM1/MYD88/ACOX3/MAP2K4/TAB2/PRKAB2	2.22740249835068
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1738	60/9376	1.61841196777906	VEGFA/PLA2G4A/PLCG2/PPP3CC/AKT1/PTK2/SHC2/RAF1/MAPK14/MAP2K1/PIK3CA/PPP3CB/PXN/PPP3R1/PRKCA/AKT3/PIK3R2/MAPKAPK2	2.29223673482501
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/1738	78/9376	1.52158390133074	JUN/FOS/GNAI1/IRF1/NOD1/MAPK8/CFL2/TRAF6/CASP7/CASP3/MAPK14/CASP1/IL6/RELA/IL1A/MAPK9/CALM2/IRAK4/GNAI3/TICAM1/MYD88/C1S	2.2064668455393
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	35/1738	137/9376	1.37820970492134	NFKBIA/JUN/FOS/FAS/GADD45A/AKT1/EIF2AK3/BBC3/CYCS/GADD45B/GADD45G/MAPK8/RAF1/ERN1/CASP7/LMNA/EIF2S1/CASP10/CASP3/MAP2K1/PIK3CA/ACTB/RELA/BIRC2/MAPK9/MCL1/APAF1/CAPN2/AKT3/BCL2L11/PIK3R2/DDIT3/ITPR3/PARP4/ATF4	2.12716493829413
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	12/1738	37/9376	1.74963455976114	GFPT2/UGDH/UGP2/UAP1/GALK2/HK2/TGDS/GFPT1/PGM3/GNPNAT1/GNE/UAP1L1	2.17931983615873
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	12/1738	38/9376	1.70359154503059	GFPT2/UGDH/UGP2/UAP1/GALK2/HK2/GFPT1/PGM3/GNPDA2/GNPNAT1/GNE/UAP1L1	2.07303279546145
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	41/1738	170/9376	1.30107628782238	YBX3/JUN/AMOTL2/LLGL1/WHAMM/RAP2C/LLGL2/F11R/PRKCE/MAPK8/PPP2CB/CLDN23/PPP2R2D/CTTN/PPP2R1B/GATA4/NEDD4/TJAP1/PARD3/PATJ/PRKAA1/RAB8A/ACTB/ARPC1A/MAPK9/PRKAG2/ARHGAP17/AFDN/PARD6G/RAB8B/RAPGEF2/OCLN/PRKAB1/RAP1A/CLDN12/PPP2CA/CLDN15/PRKCI/MYL12B/MAGI1/PRKAB2	1.88967111810458
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	28/1738	110/9376	1.37319803326708	CPEB2/ADCY9/AKT1/GNAI1/IGF1R/MAPK8/RAF1/BRAF/MAPK14/MAP2K1/ANAPC10/PIK3CA/CDC16/CDC26/ANAPC1/MAPK9/ARAF/AKT3/SPDYE1/CDK2/PIK3R2/GNAI3/CCNA2/ANAPC4/ANAPC16/ADCY6/PGR/SPDYE5	1.87806335280978
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	34/1738	139/9376	1.31956851089899	JUN/FOS/RARA/HSPA1B/GREB1/ADCY9/AKT1/GNAI1/PLCB1/FKBP4/SHC2/ATF2/RAF1/SOS2/SOS1/PRKCD/MAP2K1/PIK3CA/NCOA3/NCOA2/KRT10/HSPA8/PLCB3/CALM2/CREB3L2/AKT3/ESR2/PIK3R2/GNAI3/ADCY6/ITPR3/ATF4/PGR/NCOA1	1.81061704526073
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	29/1738	116/9376	1.34867663981588	ALDOA/DLST/PFKP/ENO2/ME3/SUCLA2/SDHB/SDHD/SDHA/MCEE/HK2/IDH3A/SUCLG2/HIBCH/PGAM1/ACO1/PRPS2/ALDH6A1/PCCA/GLUD1/DLD/RPIA/ACAT1/PGK1/PSPH/ACOX3/DLAT/FH/ACSS2	1.80246587221947
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/1738	44/9376	1.59389057432786	OSTC/DAD1/ST3GAL3/MGAT2/ALG13/MAN2A1/B4GALT3/KRTCAP2/B4GALT1/MGAT4B/ALG9/ALG2/MAN1A1	1.88350207521266
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1738	32/9376	1.68584579976985	GABARAPL1/PPP2CB/ATG12/ATG5/GABARAPL2/ATG16L1/ATG101/PPP2CA/ATG2B/ATG13	1.8537695954183
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1738	32/9376	1.68584579976985	BBC3/CYCS/MAPK8/CASP7/CASP3/BIRC2/MAPK9/BIRC6/APAF1/BCL2L11	1.8537695954183
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	18/1738	67/9376	1.4493241502499	PPP1CB/PPP3CC/PLCB1/RAF1/CAMK2D/RAP1B/BRAF/MAP2K1/PPP3CB/PLCB3/PPP3R1/PRKCA/CALM2/ARAF/RAPGEF3/RAP1A/ITPR3/ATF4	1.76062289501887
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	27/1738	109/9376	1.33630345963408	STAT1/NFKBIA/JUN/FOS/RARA/STAT5B/AHR/IL1R1/PPP3CC/SMAD4/IFNGR2/IL1RAP/MAPK8/IFNGR1/STAT3/MAPK14/SMAD2/SMAD3/IL4R/TGFBR1/IL6/RELA/PPP3CB/MAPK9/PPP3R1/RXRB/JAK2	1.68459574625122
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	33/1738	138/9376	1.29003852504128	CPEB2/PPP1CB/SKP1/ADCY9/PPP3CC/IGF1R/PPP2CB/CAMK2D/PPP2R1B/STAG3/MAPK14/MAP2K1/ANAPC10/BTRC/YWHAQ/CDC16/CDC26/PPP3CB/ANAPC1/YWHAG/PPP3R1/CUL1/CALM2/SPDYE1/CDK2/PPP2CA/ANAPC4/ANAPC16/REC8/ADCY6/ITPR3/PGR/SPDYE5	1.63729505209417
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/1738	42/9376	1.54134473121815	SLC39A14/MAP1LC3C/FTH1/MAP1LC3B/TFRC/ATG5/PRNP/SLC7A11/VDAC2/SLC3A2/VDAC3/PCBP2	1.6772019490203
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	18/1738	69/9376	1.40731475459048	PLA2G4A/PLCG2/AKT1/MAPK8/RAF1/SOS2/VAV2/MAPK14/SOS1/MAP2K1/FYN/PIK3CA/MAPK9/PRKCA/AKT3/PIK3R2/GAB2/MAP2K4	1.61983406506272
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1738	51/9376	1.48089983979783	SEC61G/ERO1A/PLCG2/ADCY9/ARF1/PDIA4/SEC61B/ATP6V1E2/ATP6V1D/ACTB/PRKCA/KDELR2/ATP6V1G1/ATP6V0A2	1.64261580581873
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/1738	97/9376	1.33477275693118	FOS/RASD1/ADCY9/GUCY1B1/GNAI1/PLCB1/CAMK2D/PER1/GNG4/GNB5/PRKG1/GUCY1A2/GNG5/GNGT1/PLCB3/NOS1AP/GNG12/PRKCA/CALM2/GNB2/GUCY1A1/GNAI3/ADCY6/ITPR3	1.58090613871525
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1738	21/9376	1.79823551975451	CHSY1/CHST3/XYLT1/CSGALNACT2/CHST7/CHST14/CHST15	1.74678517632983
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	42/1738	184/9376	1.23140041026667	SEMA4C/WNT4/PLCG2/PPP3CC/ABL1/WNT5A/PTK2/GNAI1/NCK1/RYK/RAF1/CFL2/CAMK2D/PLXNA3/DPYSL2/FYN/BOC/PIK3CA/SEMA3A/ARHGEF12/NCK2/PARD3/NTN1/PPP3CB/SRGAP2/SEMA3C/PLXNA4/PPP3R1/PRKCA/RRAS/PARD6G/PLXNA2/LIMK1/EPHA2/SEMA3G/EPHA5/RND1/PIK3R2/GNAI3/PAK4/ILK/MYL12B	1.51212859271279
Organismal Systems	Immune system	hsa04611	Platelet activation	30/1738	126/9376	1.28445394268179	PLA2G4A/F2R/PPP1CB/PLCG2/ADCY9/AKT1/GUCY1B1/GNAI1/PLCB1/FGG/RAP1B/PTGIR/SNAP23/MAPK14/PRKG1/FYN/PIK3CA/ARHGEF12/GUCY1A2/ACTB/PLCB3/AKT3/GUCY1A1/PIK3R2/GNAI3/RAP1A/PRKCI/ADCY6/ITPR3/MYL12B	1.53337034947907
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/1738	56/9376	1.44501068551701	OSTC/DAD1/MOGS/DHRSX/MGAT2/ALG13/DPM1/MAN2A1/B4GALT3/KRTCAP2/B4GALT1/MGAT4B/ALG9/ALG2/MAN1A1	1.59322529852049
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1738	34/9376	1.58667839978339	POLR2M/POLR2C/POLR3D/POLR2J3/POLR2A/POLR2K/POLR1D/POLR2H/CRCP/POLR2B	1.63470850823352
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	19/1738	75/9376	1.36665899501343	MGST1/FAS/GSTT2B/AKT1/BBC3/GSTA1/CYCS/CDKN1A/CASP3/MDM2/PIK3CA/MLH1/BIRC2/CDKN2A/APAF1/ATP7B/AKT3/MSH6/PIK3R2	1.52071857416915
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/1738	205/9376	1.21051952061523	COX7A1/GFPT2/PPP1CB/AKT1/INSR/PLCB1/SDHB/TGFB2/MAPK8/NDUFA7/NDUFC2/IRS1/SDHD/SDHA/CAMK2D/TGFB3/MAPK14/NDUFS4/SMAD2/SMAD3/TGFBR1/PRKCD/NDUFA13/GFPT1/PIK3CA/NDUFA5/NDUFB3/NDUFB5/VDAC2/RELA/MAPK9/PLCB3/PDK4/PRKCA/CPT1B/VDAC1/ATP2A2/PTEN/AKT3/COX7A2L/PPARA/GSR/PIK3R2/NDUFV3/VDAC3/NDUFB8	1.45372297247013
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/1738	99/9376	1.30780765073055	PLA2G4A/PTGER2/PPP1CB/PLCG2/ADCY9/IL1R1/IL1RAP/PRKCE/PLCB1/MAPK8/BDKRB1/CAMK2D/HTR2B/MAPK14/PRKCD/PIK3CA/MAPK9/PLCB3/PRKCA/CALM2/PIK3R2/ADCY6/ITPR3/TRPV3	1.46863517769855
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1738	71/9376	1.36767208544709	MYC/LDHA/GLS/AKT1/PFKP/RAF1/HK2/PDGFRB/MAP2K1/FGFR2/PIK3CA/PGAM1/FGFR3/PDK1/RET/PTEN/AKT3/PIK3R2	1.48337973376856
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	26/1738	109/9376	1.2868107389069	IRF7/STAT1/NFKBIA/JUN/FOS/STAT2/IRF9/TBK1/AKT1/MAPK8/TRAF6/MAP3K8/MAPK14/MAP2K1/PIK3CA/IL6/MAP3K7/RELA/MAPK9/AKT3/IRAK4/PIK3R2/TICAM1/MYD88/MAP2K4/TAB2	1.43667909710899
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1738	14/9376	1.92668091402269	ST3GAL3/CHST2/B4GALT3/B4GALT4/B4GALT1	1.65512430054424
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	48/1738	217/9376	1.19329914674953	JUN/KLF4/VEGFA/FOS/MGST1/MYC/DLL4/STAT5B/ADCY9/AHR/GSTT2B/BCL6/AKT1/GNAI1/GSTA1/ATF2/RAF1/SOS2/FGF2/ARNT/STAT3/SOS1/RPS6KB1/KPNA5/MAP2K1/PIK3CA/KPNA4/NOTCH2/RELA/CCND3/CACNA1A/PTGES3/PRKCA/CREB3L2/RB1/VDR/AKT3/FGF22/PPARA/FGF10/ESR2/RXRB/PIK3R2/GNAI3/JAK2/ADCY6/ATF4/PGR	1.3742206543675
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	50/1738	227/9376	1.18826135666597	COX7A1/NFKBIA/JUN/VEGFA/FOS/MGST1/AHR/GSTT2B/AKT1/ABL1/PTK2/GSTA1/PRKD3/SDHB/MAPK8/SOD2/NDUFA7/RAF1/NDUFC2/SDHD/SDHA/SOS2/ARNT/BRAF/MAPK14/PLD1/NDUFS4/SOS1/PRKCD/MAP2K1/NDUFA13/PIK3CA/NDUFA5/NDUFB3/NDUFB5/VDAC2/RELA/MAPK9/VDAC1/PTEN/ACP1/ARAF/AKT3/COX7A2L/PIK3R2/NDUFV3/VDAC3/MAP2K4/NDUFB8/PRKD1	1.3696449357901
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1738	31/9376	1.56620513010876	SEC61G/SRP54/IMMP2L/SRP9/SPCS3/SEC61B/SRPRB/SRP19/HSPA5	1.50621057100246
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/1738	115/9376	1.26658327913144	FOS/ADCY9/AKT1/GNAI1/PLCB1/CAMK2D/GNG4/GNB5/MAP2K1/FYN/PIK3CA/GNG5/GNGT1/PLCB3/CACNA1A/GNG12/PRKCA/CREB3L2/AKT3/GNB2/PIK3R2/GNAI3/GNA11/JAK2/ADCY6/ITPR3/ATF4	1.37206150894923
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1738	154/9376	1.22606967255989	JUN/FOS/PLA2G4A/PPP1CB/ADCY9/PPP3CC/GUCY1B1/GNAI1/PLCB1/RAF1/CAMK2D/CDKN1A/CACNA2D1/CACNB2/MAPK7/MAP2K1/RCAN1/EEF2K/GUCY1A2/PRKAA1/ACTB/PPP3CB/PRKAG2/PLCB3/PPP1R12B/PPP3R1/PRKCA/CALM2/OXTR/GUCY1A1/GNAI3/PRKAB1/ADCY6/ITPR3/PRKAB2	1.34930709497707
NA	NA	hsa04517	IgSF CAM signaling	64/1738	299/9376	1.15471979863835	PMP22/TUBB2A/LRFN5/PLCG2/TUBB4B/AKT1/ABL1/PTK2/IL1RAP/F11R/CTNNB1/NCK1/FGG/TRIO/MAPK8/NFASC/BAIAP2/TRAF6/RAP1B/DYNLL1/BCAR1/PLXNA3/VAV2/NECTIN3/NCAM2/MAPK14/MAP2K1/FYN/FOXO1/PIK3CA/PVR/NCK2/NRCAM/PARD3/NTN1/ACTB/ARPC1A/PXN/SRGAP2/MAPK9/KIRREL1/PLXNA4/PRKCA/SORBS1/GRIP2/AFDN/PARD6G/PLXNA2/RAPGEF2/AKT3/NECTIN1/MAGI2/PIK3R2/RAP1A/LRRTM4/ANK3/TUBB2B/PAK4/PRKCI/CADM1/CABLES1/MYL12B/MAGI1/LRFN4	1.29697323901633
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	14/1738	54/9376	1.39862762647573	HES1/POLK/POLI/WDR48/MLH1/PMS2/TOP3B/FAN1/RPA4/FANCC/RPA3/ATR/FANCF/MUS81	1.40129774002138
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	12/1738	45/9376	1.43858841580361	ABCA8/ABCA5/TAP2/TAP1/ABCC9/ABCA1/ABCB7/ABCD3/ABCA6/ABCA10/ABCC3/ABCB10	1.40676001647901
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	45/1738	205/9376	1.18420387886272	IRF7/GTF2H2/NFKBIA/JUN/EIF2AK2/GTF2H2C/IRF9/STAT5B/SP100/GTF2B/TBPL1/ATF2/CDKN1A/GTF2A2/STAT3/CASP3/MDM2/RASA2/PIK3CA/DDX3X/YWHAQ/HLA-F/RELA/PXN/CCND3/YWHAG/GTF2A1/CDKN2A/KAT2A/CREB3L2/RB1/CDKN2B/RBL1/DNAJA3/CDK2/RANBP1/PIK3R2/VDAC3/CCNA2/RBL2/UBE3A/KAT2B/MAPKAPK2/HDAC4/ATF4	1.27200275555575
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	65/1738	308/9376	1.13849326737704	COX7A1/PSMA2/TUBB2A/TGM2/TUBB4B/PSMD9/BBC3/PLCB1/CYCS/SDHB/POLR2C/MAPK8/TBPL1/SOD2/NDUFA7/NDUFC2/SDHD/ULK1/SDHA/ERN1/NRF1/PSMA3/KLC1/POLR2J3/CASP3/NDUFS4/DLG4/ACTR10/DCTN6/PSMD11/NDUFA13/TAF4/NDUFA5/PSMC6/NDUFB3/POLR2A/NDUFB5/VDAC2/POLR2K/MAPK9/PLCB3/PSMA1/KLC2/GPX8/VDAC1/PSMB2/CREB3L2/KLC4/APAF1/AP2A1/RCOR1/SLC1A3/COX7A2L/IFT57/POLR2H/ATG101/PSMA5/SIN3A/NDUFV3/VDAC3/ATG2B/TUBB2B/ATG13/NDUFB8/POLR2B	1.17887826631116
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	42/1738	193/9376	1.17397759320761	STAT1/NFKBIA/STAT2/STAT5B/PLCG2/ADCY9/AKT1/GRK5/PTK2/GNAI1/PLCB1/SHC2/ELMO1/RAF1/SOS2/RAP1B/BCAR1/GNG4/VAV2/BRAF/STAT3/SOS1/GNB5/PRKCD/MAP2K1/PIK3CA/GNG5/GNGT1/PARD3/RELA/PXN/CRKL/PLCB3/GNG12/AKT3/GNB2/CXCL1/PIK3R2/GNAI3/RAP1A/JAK2/ADCY6	1.16493147128502
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	30/1738	134/9376	1.20777012520825	PLA2G4A/ADM/ARHGEF11/PPP1CB/ADCY9/GUCY1B1/PLA2G5/PRKCE/PLCB1/RAF1/PTGIR/BRAF/GNA12/PRKG1/PRKCD/MAP2K1/ARHGEF12/GUCY1A2/KCNMA1/PLCB3/PPP1R12B/ADORA2B/PRKCA/CALM2/ARAF/NPPC/GUCY1A1/GNA11/ADCY6/ITPR3	1.15550868970557
NA	NA	hsa04518	Integrin signaling	34/1738	154/9376	1.19103911048675	VEGFA/PDGFA/THBS1/FERMT2/AKT1/PTK2/ITGA1/IGF1R/CTNNB1/ITGB8/FGG/COL6A3/ARHGEF6/COL6A6/PDGFRB/ITGA3/PIK3CA/NCK2/COL4A6/ACTB/LAMA5/PXN/CCND3/ITGA11/THBS2/COL4A1/ITGAV/PARVA/AKT3/VEGFB/PIK3R2/TNC/LAMC3/ILK	1.14022559629086
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/1738	20/9376	1.61841196777906	LSS/MSMO1/CYP51A1/SQLE/HSD17B7/SOAT1	1.32059142867598
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1738	20/9376	1.61841196777906	UGDH/UGP2/UAP1/TGDS/GNE/UAP1L1	1.32059142867598
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/1738	71/9376	1.29169030292225	NFKBIA/JUN/PLCG2/F11R/NOD1/MAPK8/CASP3/MAPK14/ATP6V1E2/ATP6V1D/RELA/MAPK9/CXCL1/ATP6V1G1/ATP6V0A2/MAP2K4/ADAM17	1.1768298465344
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	24/1738	105/9376	1.23307578497452	NFKBIA/GADD45A/PLCG2/IL1R1/PPP1R13L/GADD45B/GADD45G/TRIM25/TRAF6/BCL10/TAB3/CSNK2A2/MAP3K7/RELA/CSNK2B/BIRC2/CSNK2A1/IRAK4/CXCL1/UBE2I/PLAU/TICAM1/MYD88/TAB2	1.14564275182935
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	26/1738	116/9376	1.20915836673148	SLC38A2/PLA2G4A/GLS/ADCY9/SLC38A1/PPP3CC/GNAI1/PLCB1/GNG4/PLD1/GNB5/DLG4/GNG5/GNGT1/PPP3CB/PLCB3/CACNA1A/PPP3R1/GNG12/PRKCA/SLC1A3/GNB2/GNAI3/DLGAP1/ADCY6/ITPR3	1.08123336889368
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	39/1738	181/9376	1.16239533597391	CEBPB/STAT1/KSR1/IL10RB/PPP3CC/AKT1/IFNGR2/CYCS/TGFB2/MAPK8/IFNGR1/RAF1/CAMK2D/TRAF6/TGFB3/HSPA9/NFYB/BCL10/CASP10/CASP3/MAPK14/RAB5A/IL6/ARHGEF12/RELA/PLK3/PPP3CB/NFYA/IL1A/MAPK9/PPP3R1/CALM2/APAF1/VDR/AKT3/IRAK4/ATP6V0A2/MYD88/JAK2	1.05234385630439
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/1738	78/9376	1.24493228290697	STAT1/NFKBIA/JUN/FOS/IFNGR2/TGFB2/IFNGR1/TRAF6/TGFB3/MAPK14/MAP3K7/RELA/IL1A/MARCKSL1/IRAK4/MYD88/JAK2/TAB2	1.0361419519614
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/1738	69/9376	1.25094644852487	PTGER2/PPP3CC/GUCY1B1/GNAI1/PLCB1/PDE3A/GUCY1A2/KCNMA1/PPP3CB/PLCB3/PPP3R1/CALM2/GUCY1A1/GNAI3/ADCY6/ITPR3	0.997979084346668
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/1738	69/9376	1.25094644852487	JUN/FOS/SIRT1/FOSB/PPP1CB/PPP3CC/MAOB/ARC/ATF2/CAMK2D/PPP3CB/PPP3R1/PRKCA/CALM2/CREB3L2/ATF4	0.997979084346668
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	49/1738	235/9376	1.12485370810176	COX7A1/RHEB/ADCY9/ARID1B/SDHB/ATF2/NDUFA7/NDUFC2/SDHD/SDHA/COX16/SOS2/MAPK14/NDUFS4/SOS1/PRKG1/RPS6KB1/ZNF516/NDUFA13/TSC1/NDUFA5/NDUFAF4/COA6/NDUFB3/NDUFB5/PRKAA1/FRS2/ACTB/NDUFAF7/ATP5MGL/PRKAG2/CPT1B/CNR1/COA1/CREB3L2/KDM3A/KDM1A/SMARCD3/COX7A2L/KDM3B/COA4/PRKAB1/NDUFV3/ACTL6A/SMARCE1/COA5/ADCY6/NDUFB8/PRKAB2	0.924611347564876
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	22/1738	99/9376	1.19882367983634	ITGA1/ITGB8/TGFB2/TGFB3/LMNA/DMD/CACNA2D1/CACNB2/ITGA3/IL6/SGCE/PRKAA1/ACTB/PRKAG2/SNTB2/ITGA11/SGCB/ITGAV/ATP2A2/PRKAB1/ACTC1/PRKAB2	0.948642600903804
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/1738	41/9376	1.31578208762525	POLD4/UIMC1/RAD52/BABAM2/TOP3B/RAD50/ABRAXAS1/RPA4/RPA3/MUS81	0.966591464936495
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1738	27/9376	1.39862762647573	ACOT2/ELOVL2/HACD1/ELOVL5/HSD17B4/ACOX3/ELOVL3	0.98943528307745
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/1738	233/9376	1.11135585770236	PDLIM3/VIM/FBLN2/THBS1/COL27A1/SUN1/PDLIM1/ENO2/ITGA1/TMEM43/FHL2/AGRN/ITGB8/DAAM2/PDLIM2/COL6A3/COL6A6/DIAPH2/LMNA/DMD/SUN2/DCN/ATP1B1/ITGA3/CSRP1/SGCE/ELN/SDC4/COL5A3/FMNL2/CAPZA2/COL4A6/CAPZA1/ACTB/NEBL/SNTB2/ITGA11/THBS2/COL4A1/SGCB/ITGAV/SYNE3/MYH7B/HSPG2/SYNPO2/ACTC1/ANK3/SDC2	0.821045764821214
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1738	23/9376	1.40731475459048	RCE1/HMGCS1/FNTA/NUS1/ACAT1/IDI1	0.93290901613137
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1738	23/9376	1.40731475459048	POLD4/MLH1/PMS2/RPA4/MSH6/RPA3	0.93290901613137
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1738	52/9376	1.24493228290697	MYLIP/ANGPTL4/VAPA/LDLRAP1/ABCA1/VDAC2/VDAC1/STARD3NL/VDAC3/SOAT1/LDLR/LRPAP1	0.844825992143715
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1738	28/9376	1.34867663981588	ST8SIA1/A4GALT/ST3GAL3/B4GALT3/B4GALT4/B4GALT1/FUT4	0.881380044021655
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1738	33/9376	1.30780765073055	BET1/SEC22B/STX2/STX5/SNAP23/GOSR1/STX7/STX11	0.844916717261904
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1738	128/9376	1.13794591484465	AK4/PDE4D/ADCY9/GUCY1B1/ADSL/PDE8A/PDE3A/AK6/NME7/HPRT1/GUCY1A2/PDE7B/RRM2B/PPAT/ENTPD4/PRPS2/PDE10A/PAICS/AK3/AK2/PDE6D/GUCY1A1/DCK/PAPSS1/DGUOK/ADCY6/PRUNE1	0.749567270884087
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1738	98/9376	1.15600854841361	ADCY9/NR4A1/PRKCE/PRKD3/PLCB1/ATF2/CAMK2D/ATP2B4/ATP1B1/PLCB3/PRKCA/CALM2/CREB3L2/ATF1/GNA11/ADCY6/ITPR3/ATF4/PRKD1/LDLR/KCNK3	0.740550956063303
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	20/1738	93/9376	1.16015194822871	STAT1/NFKBIA/JUN/FOS/DLL4/STAT5B/MAML2/PPP3CC/IFNGR2/MAPK8/IFNGR1/MAPK14/MAML1/IL4R/NOTCH2/RELA/PPP3CB/MAPK9/PPP3R1/JAK2	0.740372403305606
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/1738	48/9376	1.23628691983122	AUH/HIBADH/AACS/MCEE/HIBCH/HADHB/HMGCS1/ALDH6A1/PCCA/DLD/ACAT1	0.782864731357944
NA	NA	hsa03272	Virion - Hepatitis viruses	11/1738	48/9376	1.23628691983122	CLDN23/PDCD6IP/TSG101/IST1/CHMP4B/CHMP7/OCLN/HSPG2/CLDN12/CLDN15/LDLR	0.782864731357944
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/1738	63/9376	1.19882367983634	PLOD2/DLST/AASS/KMT5A/PHYKPL/KMT5C/DLD/SETD7/KMT2B/GCDH/ACAT1/TMLHE/EHMT1/SMYD2	0.755290944799318
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1738	44/9376	1.22606967255989	ADCY9/DYNLL1/DYNC2LI1/DCTN6/RAB5A/DYNC1I1/DYNC2H1/CREB3L2/RAB11A/ADCY6	0.716971637226451
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/1738	59/9376	1.18866415712586	IRS2/ADCY9/AKT1/GNAI1/ABHD5/INSR/IRS1/PRKG1/PIK3CA/AKT3/PIK3R2/GNAI3/ADCY6	0.693422700491351
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1738	49/9376	1.21105657452855	JUN/FOSB/MAOB/GNAI1/ATF2/GPSM1/DLG4/RELA/CREB3L2/GNAI3/ATF4	0.706556073789113
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1738	85/9376	1.14240844784404	AK4/UCKL1/CMPK1/NT5C3A/ADSL/CMPK2/AK6/DUT/DCTD/NME7/HPRT1/RRM2B/TYMP/ENTPD4/AK3/AK2/DCK/DGUOK	0.629121725559435
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/1738	65/9376	1.16193679737984	ADCY9/NR4A1/PLCB1/PDE8A/ATF2/PBX1/PLCB3/CREB3L2/GNA11/ADCY6/ITPR3/ATF4/LDLR/KCNK3	0.624920480798989
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/1738	55/9376	1.1770268856575	CERS2/UGCG/SPTLC1/SMPD4/DEGS1/CERS5/CERS6/SAMD8/SGPL1/PLPP3/KDSR/PLPP1	0.628072845294863
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	45/1738	226/9376	1.07416723525159	NFKBIA/JUN/FOS/PTGER2/F2R/PPP1CB/PDE4D/ADCY9/AKT1/GNAI1/MAPK8/RAF1/CAMK2D/RAP1B/PDE3A/VAV2/BRAF/PLD1/ATP2B4/RRAS2/ATP1B1/MAP2K1/PIK3CA/RELA/MAPK9/AMH/PDE10A/RRAS/CALM2/ATP2A2/CREB3L2/AFDN/OXTR/AKT3/PPARA/RAPGEF3/PIK3R2/GNAI3/RAP1A/SSTR2/ADCY6/HCAR3/ACOX3/ARAP3/GLI3	0.53836455605089
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/1738	91/9376	1.12636730358249	IFITM1/NFKBIA/JUN/FOS/PLCG2/PPP3CC/AKT1/RAF1/SOS2/BCL10/VAV2/SOS1/MAP2K1/PIK3CA/RELA/PPP3CB/PPP3R1/AKT3/PIK3R2	0.577810138649529
Human Diseases	Substance dependence	hsa05032	Morphine addiction	19/1738	91/9376	1.12636730358249	PDE4D/ADCY9/GRK5/GNAI1/PDE8A/PDE3A/GNG4/GABRE/GNB5/GNG5/PDE7B/GNGT1/CACNA1A/PDE10A/GNG12/PRKCA/GNB2/GNAI3/ADCY6	0.577810138649529
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/1738	66/9376	1.14433169438923	STAT1/JUN/IL18R1/IFNGR2/TGFB2/IFNGR1/TGFB3/STAT3/SMAD2/SMAD3/IL4R/IL6/RELA/IL1A	0.561279957663849
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1738	31/9376	1.21815954564015	AFMID/MCEE/ACO1/PCCA/DLD/ACAT1/ACSS2	0.580344819103224
NA	NA	hsa04081	Hormone signaling	43/1738	219/9376	1.05923462122526	PRL/IRS2/ADRA2C/STAT5B/ADCY9/EPOR/THRB/GNAI1/SMAD4/IGF1R/INSR/PLCB1/IRS1/ADIPOR1/GNG4/GNA12/STAT3/GNB5/PRKG1/LEPR/BMPR1A/PIK3CA/GNG5/GNGT1/UCN/AMH/PLCB3/GNG12/ITGAV/OXTR/NPPC/HCRTR2/GNB2/ESR2/RAPGEF3/PTH1R/NPR3/PIK3R2/GNAI3/GNA11/SSTR2/JAK2/ADCY6	0.423098770478426
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1738	104/9376	1.0893157475436	PLA2G4A/CHPT1/ETNK1/LPIN1/PLA2G5/LPIN3/CEPT1/PLD1/SAMD8/PLPP5/CRLS1/CHKA/CHKB/GPAT3/PLPP3/GPD1L/PLPP1/GNPAT/AGPAT1/PTDSS2/DGKD	0.43689662808503
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1738	78/9376	1.10660647369508	PTK2/CTNNB1/SHC2/ELMO1/CTTN/BCAR1/ARHGEF26/PIK3CA/WASF1/ACTB/ARPC1A/CAV2/PXN/CRKL/PIK3R2/ILK	0.450979505172455
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1738	47/9376	1.14780990622628	LDHA/ME3/ACYP1/ACYP2/DLD/ACAT1/ACACB/DLAT/FH/ACSS2	0.484568993490027
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1738	37/9376	1.16642303984076	GFPT2/GLS/ADSL/ASPA/GFPT1/PPAT/GLUD1/CAD	0.48382111949904
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	23/1738	115/9376	1.0789413118527	DUSP1/PLA2G4A/MAOB/GNAI1/PLCB1/RAF1/GNG4/BRAF/HTR2B/CASP3/GNB5/MAP2K1/GNG5/GNGT1/PLCB3/CACNA1A/GNG12/PRKCA/ARAF/GNB2/RAPGEF3/GNAI3/ITPR3	0.406298308775966
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/1738	89/9376	1.09106424794094	THBS1/ITGA1/AGRN/ITGB8/COL6A3/COL6A6/ITGA3/SDC4/COL4A6/LAMA5/CD47/ITGA11/THBS2/COL4A1/ITGAV/HSPG2/TNC/LAMC3	0.411742676304766
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	18/1738	89/9376	1.09106424794094	SLC38A2/GLS/ADCY9/SLC38A1/GNAI1/GABARAPL1/GNG4/GABRE/GNB5/GNG5/GNGT1/GABARAPL2/CACNA1A/GNG12/PRKCA/GNB2/GNAI3/ADCY6	0.411742676304766
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/1738	53/9376	1.11965607833771	ADCY9/PLCB1/ATP2B4/ATP1B1/PLCB3/PRKCA/AP2A1/VDR/PTH1R/RAB11A/ADCY6	0.416692376412565
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/1738	116/9376	1.06964009364708	PLCG2/PTK2/GNAI1/F11R/CTNNB1/CLDN23/RAP1B/BCAR1/VAV2/MAPK14/PIK3CA/ACTB/PXN/PRKCA/AFDN/OCLN/RAPGEF3/PIK3R2/GNAI3/RAP1A/CLDN12/CLDN15/MYL12B	0.360000865567903
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1738	59/9376	1.09722845273156	UCKL1/CMPK1/NT5C3A/CMPK2/DUT/DCTD/NME7/RRM2B/TYMP/ENTPD4/DCK/CAD	0.357356782999006
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	29/1738	149/9376	1.04997644442042	ADCY9/GNAI1/PLCB1/MAPK8/NDUFA7/NDUFC2/GNG4/GABRE/MAPK14/NDUFS4/GNB5/NDUFA13/NDUFA5/NDUFB3/GNG5/NDUFB5/GNGT1/MAPK9/PLCB3/CACNA1A/GNG12/PRKCA/CNR1/GNB2/GNAI3/NDUFV3/ADCY6/ITPR3/NDUFB8	0.293324896497816
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1738	28/9376	1.15600854841361	ACOT2/ELOVL2/HADHB/HACD1/ELOVL5/ELOVL3	0.39435627617942
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1738	49/9376	1.10096052229868	OGT/ST3GAL3/POFUT2/GXYLT2/B4GALT3/B4GALT1/GALNT15/EOGT/C1GALT1C1/GALNT2	0.337986487283787
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1738	18/9376	1.19882367983634	THAP11/MTRR/LMBRD1/ZNF143	0.402748133906912
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1738	50/9376	1.0789413118527	OAT/P4HA1/AMD1/ODC1/MAOB/CKB/L3HYPDH/ALDH18A1/P4HA3/P4HA2	0.266969921078577
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	45/1738	238/9376	1.02000754271789	MX2/MX1/ISG15/OAS2/OAS1/OAS3/STAT1/NFKBIA/JUN/RPL17/EIF2AK2/FOS/IFIH1/RPS10/RPL36A/STAT2/IRF9/PLCG2/TBK1/RPL22L1/CFB/FGG/ADAR/CSF3/MAPK8/TRAF6/CGAS/STAT3/MAPK14/CASP1/PIK3CA/IL6/RPS21/MAP3K7/RELA/MAPK9/PRKCA/IRAK4/PIK3R2/RSL24D1/MYD88/TAB2/ADAM17/RPS27L/C1S	0.14913423532074
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/1738	88/9376	1.04215922167591	SERPINE1/CFH/F2R/CFB/F3/FGG/BDKRB1/TFPI/PLAT/CD59/CD55/SERPINB2/CD46/F5/PLAU/PROS1/C1S	0.189536787099151
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	16/1738	83/9376	1.03994343311104	IRF7/NFKBIA/TBK1/ADAR/CGAS/CASP7/POLR3D/CASP3/CASP1/IL6/RELA/POLR2K/POLR1D/POLR2H/G3BP1/IFI16	0.174352092638302
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1738	51/9376	1.05778559985559	PLA2G4A/CHPT1/PLA2G5/CEPT1/PLD1/GDPD3/PLPP3/PLPP1/PAFAH1B1/PAFAH1B2	0.19737902119372
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1738	19/9376	1.13572769668706	DLST/DLD/LIAS/DLAT	0.282486476808347
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1738	30/9376	1.0789413118527	PIGF/PIGA/PIGL/PIGC/PIGO/PIGN	0.20657262842963
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	29/1738	154/9376	1.01588630012105	PPP1CB/ADCY9/AKT1/GNAI1/PLCB1/PPP2CB/ATF2/PPP2R2D/CAMK2D/PPP2R1B/CACNA2D1/CACNB2/MAPK14/ATP2B4/ATP1B1/PPP2R3C/PLCB3/PRKCA/CALM2/ATP2A2/CREB3L2/AKT3/RAPGEF3/PPP2R3A/GNAI3/ACTC1/PPP2CA/ADCY6/ATF4	0.0948181028598285
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1738	52/9376	1.03744356908914	PLA2G4A/ADCY9/ACOT2/IGF1R/INSR/BMP6/HSD17B7/ADCY6/HSD17B2/LDLR	0.129151208773687
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/1738	75/9376	1.00701189106252	ALDOA/PFKP/ENO2/MAT2A/MAT2B/IDH3A/ALDH18A1/PGAM1/ACO1/PRPS2/RPIA/CTH/PGK1/PSPH	0.0290818256850361
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1738	75/9376	1.00701189106252	ADCY9/PLCB1/ATF2/PDIA4/ATP1B1/PLCB3/PRKCA/GPX8/CREB3L2/GSR/ADCY6/ITPR3/ATF4/HSPA5	0.0290818256850361
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1738	86/9376	1.00366633660717	ITGA1/CTNNB1/ITGB8/LMNA/DMD/CACNA2D1/CACNB2/ITGA3/SGCE/ACTB/SNTB2/ITGA11/SGCB/ITGAV/ATP2A2/TCF7L2	0.0162927502757225
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	31/1738	168/9376	0.995451805578388	STAT1/EIF2AK2/PLA2G4A/STAT2/FAS/IRF9/STAT5B/IFNGR2/CHMP5/MAPK8/IFNGR1/CAMK2D/STAT3/TRPM7/FTH1/CASP1/PPID/VDAC2/BIRC2/IL1A/MAPK9/GLUD1/CHMP4B/VDAC1/CAPN2/USP21/CHMP7/SHARPIN/VDAC3/TICAM1/JAK2	-0.0283747277978984
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1738	15/9376	1.0789413118527	AK4/ACP1/AK2	0.145951829560823
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1738	103/9376	0.995140044912688	IL1R1/PTK2/PLCB1/TGFB2/TGFB3/CASP3/RAB5A/PIK3CA/IL6/COL4A6/LAMA5/RELA/PLCB3/PRKCA/COL4A1/CXCL1/PIK3R2/GNA11/LAMC3	-0.0236570961777163
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1738	65/9376	0.995945826325573	AKT1/PLCB1/RAF1/MAP2K1/PIK3CA/PLCB3/PRKCA/AKT3/ESR2/PIK3R2/GNA11/ITPR3	-0.0156452159290446
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1738	10/9376	1.0789413118527	ETHE1/PAPSS1	0.119137356588245
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	19/1738	105/9376	0.976184996438161	ADCY9/ITGA1/ITGB8/TGFB2/TGFB3/LMNA/DMD/CACNA2D1/CACNB2/ITGA3/SGCE/ACTB/SNTB2/ITGA11/SGCB/ITGAV/ATP2A2/ACTC1/ADCY6	-0.117058433240475
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1738	61/9376	0.972815936916373	CYBRD1/TRPM7/FTH1/ATP2B4/ATP1B1/MT2A/MT1E/CLCN2/SLC30A1/ATP7B/VDR	-0.101603473296681
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1738	57/9376	0.946439747239214	ELOVL2/HADHB/HACD1/CPT1B/ACADVL/ACAT1/ELOVL5/HSD17B4/ACOX3/ELOVL3	-0.193471093842468
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/1738	46/9376	0.938209836393656	PSMA2/PSMD9/PSMA3/PSMD11/PSMC6/PSMA1/PSMB2/PSMA5	-0.200390964849457
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1738	23/9376	0.938209836393656	ST3GAL3/B4GALT3/B4GALT1/FUT4	-0.141523478064396
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1738	154/9376	0.945825175974773	MTHFD1L/UGDH/AK4/CMPK1/UGP2/PTS/ADSL/NADK2/AFMID/MAT2A/CPOX/VKORC1/CMPK2/MAT2B/NMNAT3/AK6/NME7/HSD17B6/FPGS/NADK/AK3/DLD/EARS2/AK2/CAD/LIAS/PANK3	-0.323344894512585
NA	NA	hsa04519	Cadherin signaling	72/1738	404/9376	0.961432852145974	NFKBIA/VIM/AMOTL2/PRICKLE2/WNT4/PPP1CB/LATS2/TEAD1/WNT5A/PTK2/PCDHGA10/IGF1R/CTNNB1/SAV1/DVL1/RYK/DAAM2/MAPK8/RAF1/WTIP/WNT6/STK3/YAP1/NCKAP1/AXIN2/ATN1/AJUBA/VAV2/GABRE/PDGFRB/MAPK14/CDH11/FZD7/TEAD3/RRAS2/FZD2/MAP2K1/FAT1/YWHAQ/AXIN1/ERBIN/WNT9A/WASF1/ACTB/RELA/ARPC1A/CSNK1A1/KRT10/MAPK9/PSEN1/SHOC2/YWHAG/CDH8/WNT2B/PCDHB3/RRAS/WWTR1/PCDHB2/PCDHGA6/FZD6/FZD1/AFDN/TCF7L2/NCSTN/WNT10A/WNT11/PCDHGB6/PCDHGA5/LATS1/WNT7B/PCDHGB5/MOB1A	-0.377993446369185
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/1738	93/9376	0.928121558582972	ADCY9/GUCY1B1/CST2/PLCB1/PRKG1/ATP2B4/ATP1B1/GUCY1A2/KCNMA1/PLCB3/PRKCA/CALM2/GUCY1A1/ADCY6/ITPR3/PRH1	-0.332289522583811
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1738	76/9376	0.922778753558234	ADCY9/GNAI1/PLCB1/CAMK2D/ATP1B1/ACTB/PLCB3/PRKCA/CALM2/GNAI3/SSTR2/ADCY6/ITPR3	-0.322420633138941
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1738	24/9376	0.899117759877254	XYLT1/HS3ST3B1/EXT1/HS6ST1	-0.236041728544881
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1738	36/9376	0.899117759877254	POLD4/PRIM2/RPA4/POLE4/RPA3/RNASEH2A	-0.289276548354324
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1738	12/9376	0.899117759877254	NCAM2/CD46	-0.1667997268368
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1738	48/9376	0.899117759877254	AKT1/PLCB1/HK2/ATP1B1/PIK3CA/PLCB3/AKT3/PIK3R2	-0.33424257199211
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1738	31/9376	0.870113961171536	ALDOA/PFKP/DERA/PRPS2/RPIA	-0.345520932796015
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1738	37/9376	0.874817279880571	FAS/PLCB1/IL6/PLCB3/PRKCA/MYD88	-0.363928238830804
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1738	43/9376	0.878208044531271	ECI2/HADHB/CPT1B/ACADVL/GCDH/ACAT1/ACOX3	-0.381823712139462
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1738	19/9376	0.851795772515293	IDS/ARSB/GALNS	-0.308453551427945
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1738	67/9376	0.885698091819384	LDHA/ALDOA/PFKP/ENO2/MINPP1/HK2/PGAM1/DLD/PGK1/DLAT/ACSS2	-0.447878344342745
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1738	38/9376	0.851795772515293	SIRT1/NADK2/NMNAT3/NNMT/NADK/SIRT5	-0.43666275720876
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1738	38/9376	0.851795772515293	INSR/IRS1/ATP1B1/PIK3CA/PRKCA/PIK3R2	-0.43666275720876
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1738	50/9376	0.863153049482163	THBS1/TGFB2/CSF3/TGFB3/IL6/THBS2/MYD88/SDC2	-0.462799752400356
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1738	32/9376	0.842922899884925	UGP2/PFKP/HK2/GANC/B4GALT1	-0.424563002977514
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1738	86/9376	0.878208044531271	ADCY9/PLCB1/ATF2/CAMK2D/ATP1B1/KCNMA1/RIMS2/PLCB3/PRKCA/CREB3L2/GNA11/ADCY6/ITPR3/ATF4	-0.54122851463368
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1738	39/9376	0.829954855271311	MTHFS/MTHFD1L/MAT2A/MAT2B/DLD/CTH	-0.507590584333534
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/1738	133/9376	0.892357475968402	FAS/PLCG2/PPP3CC/IFNGR2/SHC2/IFNGR1/RAF1/SOS2/VAV2/BRAF/CASP3/SOS1/ULBP1/MAP2K1/FYN/PIK3CA/PPP3CB/PPP3R1/PRKCA/ARAF/MICA/PIK3R2	-0.596381157896453
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1738	33/9376	0.817379781706594	DLST/IDH3A/ACO1/DLD/DLAT	-0.501283431324413
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	43/1738	254/9376	0.91327709467847	P2RX2/VEGFA/PDGFA/F2R/PLCG2/ADCY9/PPP3CC/PLCB1/CYSLTR2/BDKRB1/CAMK2D/FGF2/PHKG1/GDNF/PDGFRB/HTR2B/ATP2B4/FGFR2/FGFR4/VDAC2/PPP3CB/PTGFR/FGFR3/PLCB3/MCU/ADORA2B/CACNA1A/PPP3R1/RET/PRKCA/CALM2/VDAC1/ATP2A2/OXTR/ITPKA/FGF22/FGF10/EDNRB/VEGFB/VDAC3/GNA11/ITPR3/ITPKC	-0.668384454563998
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/1738	70/9376	0.847739602169982	ABL1/CYCS/DMD/CASP3/FYN/CD55/SGCE/HLA-F/ACTB/SNTB2/SGCB	-0.609923200224436
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1738	21/9376	0.770672365609074	CSAD/AASDHPPT/PANK3	-0.501839497696185
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1738	28/9376	0.770672365609074	PTS/PCBD1/MOCOS/FPGS	-0.579691259505048
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1738	28/9376	0.770672365609074	ATP6V1E2/ATP6V1D/ATP6V1G1/ATP6V0A2	-0.579691259505048
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1738	83/9376	0.84495403940272	SOD2/ECI2/FAR1/ABCD3/PEX13/PEX19/PXMP2/GNPAT/HSD17B4/ACOX3/MPV17L/PEX3/PEX5	-0.676771763961863
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	15/1738	95/9376	0.851795772515293	JUN/VEGFA/FOS/IL11/TGFB2/TGFB3/IL15/IL6/ATP6V1E2/ATP6V1D/IL1A/CSF1/CXCL1/ATP6V1G1/ATP6V0A2	-0.692541344088887
Cellular Processes	Cell motility	hsa04814	Motor proteins	32/1738	194/9376	0.889848504620787	TUBB2A/TUBE1/TUBB4B/DYNLL1/MYO9A/KLC1/DYNLT3/DYNC2LI1/TUBD1/ACTR10/DCTN6/STARD9/CAPZA2/CAPZA1/ACTB/DYNC1I1/KIFC3/DYNC2H1/KIF27/KLC2/MYO6/KLC4/KIF7/KIFAP3/KIF14/MYH7B/ACTC1/TUBB2B/DYNLT1/KIF13A/MYL12B/MYO15A	-0.739508747165097
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1738	15/9376	0.719294207901803	ST8SIA1/SLC33A1	-0.518987117942714
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1738	22/9376	0.735641803535935	MAOB/ASPA/CARNMT1	-0.592142366711381
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1738	102/9376	0.846228479884474	ADCY9/PLA2G5/PLCB1/RAP1B/ATP2B4/ATP1B1/CPB1/KCNMA1/RAB8A/PLCB3/PRKCA/ATP2A2/RAB11A/RAP1A/ADCY6/ITPR3	-0.744840263312283
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1738	155/9376	0.870113961171536	TUBB2A/SEC61G/SEC22B/TAP2/THBS1/TUBB4B/TAP1/SEC61B/RAB5A/ATP6V1E2/TFRC/ATP6V1D/HLA-F/ACTB/DYNC1I1/STX12/DYNC2H1/PIKFYVE/THBS2/ITGAV/STX7/CALR/ATP6V1G1/ATP6V0A2/TUBB2B	-0.7777857955626
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1738	42/9376	0.770672365609074	DLST/MAOB/AFMID/DLD/GCDH/ACAT1	-0.710506139958494
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1738	103/9376	0.838012669400159	SLC38A2/COL16A1/COL27A1/COL6A3/COL6A6/MME/COL8A2/SLC36A4/ATP1B1/ELN/CPB1/COL5A3/COL4A6/COL4A1/SLC3A2/COL8A1	-0.788515488461406
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1738	16/9376	0.67433831990794	MAOB/MIF	-0.621884057221636
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1738	16/9376	0.67433831990794	ST8SIA1/A4GALT	-0.621884057221636
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1738	23/9376	0.703657377295242	GLS/GLUD1/CAD	-0.678739725162279
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1738	23/9376	0.703657377295242	GLS/ATP1B1/GLUD1	-0.678739725162279
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1738	30/9376	0.719294207901803	IL6/RELA/FPGS/ABCC3	-0.734547373589909
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1738	43/9376	0.752749752455375	PLA2G5/ABCA1/PLPP3/PLPP1/ACAT1/AGPAT1	-0.775141568107337
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1738	44/9376	0.735641803535935	POLD4/POLG2/POLE4/NEIL2/PARP4/MUTYH	-0.838402280088497
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1738	17/9376	0.634671359913355	CTH/PAPSS1	-0.719141173651497
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1738	17/9376	0.634671359913355	CA5B/GLUD1	-0.719141173651497
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1738	31/9376	0.696091168937229	CSAD/HIBCH/ALDH6A1/ACOX3	-0.808453808745634
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1738	100/9376	0.809205983889528	IL11/IL1R1/EPOR/ITGA1/CSF3/MME/IL4R/CD59/CD55/ITGA3/IL6/TFRC/IL1A/CSF1/KITLG	-0.914966254862292
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/1738	138/9376	0.820933606844449	COX7A1/CYCS/SDHB/NDUFA7/NDUFC2/SDHD/SDHA/PPA1/NDUFS4/NDUFA13/NDUFA5/ATP6V1E2/NDUFB3/NDUFB5/ATP6V1D/ATP5MGL/COX7A2L/NDUFV3/ATP6V1G1/ATP6V0A2/NDUFB8	-1.01084681584354
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1738	65/9376	0.74695936974418	LPIN1/LPIN3/ABHD16A/PLPP5/GPAT3/PLPP3/PLPP1/AGPAT1/DGKD	-0.976493761021095
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/1738	59/9376	0.731485635154376	MGST1/GSTT2B/ODC1/GSTA1/PRDX6/RRM2B/GPX8/GSR	-0.986906886970374
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1738	26/9376	0.622466141453483	PLA2G4A/PLA2G5/ACOX3	-0.919512150762672
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1738	54/9376	0.699313813237864	LDHA/AMD1/MAT2A/MAT2B/MTAP/MRI1/CTH	-1.05700369462748
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1738	41/9376	0.657891043812625	MAOB/PGAM1/DLD/CTH/PSPH	-1.04717655018318
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1738	27/9376	0.599411839918169	AACS/HMGCS1/ACAT1	-0.994301531663098
Genetic Information Processing	Translation	hsa03010	Ribosome	34/1738	222/9376	0.826216319887206	RPL17/RPS10/RPL36A/MRPS6/MRPL42/MRPL32/MRPS22/RPL22L1/MRPS28/MRPL39/MRPL33/MRPL38/MRPS5/MRPL50/MRPS31/MRPL49/MRPL44/MRPS17/RPS21/MRPL53/MRPL18/MRPL22/MRPS18C/MRPL30/MRPL47/MRPL3/MRPL35/MRPL17/MRPS30/MRPL34/RSL24D1/MRPS23/MRPL9/RPS27L	-1.24997325342107
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1738	12/9376	0.449558879938627	VKORC1	-0.910104973425128
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/1738	82/9376	0.723680148193887	HSPA1B/HSPA2/TAP2/TAP1/B2M/NFYB/HLA-F/NFYA/HSPA8/CALR/HSPA5	-1.19877693038538
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1738	76/9376	0.709829810429411	ME3/ANGPTL4/HMGCS1/CPT1B/SORBS1/PPARA/RXRB/PPARD/ILK/ACOX3	-1.21154294381856
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1738	36/9376	0.599411839918169	GBE1/UGP2/HK2/GANC	-1.14867354371876
Genetic Information Processing	Transcription	hsa03040	Spliceosome	37/1738	243/9376	0.821416225073046	TRA2A/EIF4A3/SRSF6/DDX5/PHF5A/SRSF7/HSPA1B/THOC3/DDX39B/SRSF1/SRSF9/SRSF3/SNRPA1/SF3B6/CHERP/SRSF5/SF3B3/THOC1/PRPF18/BUD13/MAGOHB/SNRNP40/LSM8/HSPA8/ALYREF/PLRG1/THOC7/MAGOH/THOC6/LSM6/SF1/PRPF3/ACIN1/SRSF10/CWC15/SRSF2/PRPF4	-1.34542379443564
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1738	13/9376	0.414977427635656	RAD50	-1.00683310026709
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	50/1738	323/9376	0.835093894622836	SOCS1/IRS2/TIMP3/VEGFA/VIM/DDIT4/MYC/PIM1/PDGFA/HOXD10/SIRT1/GLS/PLCG2/BMI1/THBS1/ABL1/PRKCE/TGFB2/RAF1/IRS1/SOS2/MDM4/CDKN1A/PDGFRB/STAT3/MAPK7/CASP3/SOS1/MDM2/MAP2K1/PIK3CA/ZFPM2/NOTCH2/CCNG1/FGFR3/CRKL/PRKCA/CDKN2A/MCL1/PTEN/BCL2L2/BCL2L11/UBE2I/IGF2BP1/PIK3R2/TNC/PLAU/SPRY2/PAK4/HDAC4	-1.43867412647215
NA	NA	hsa04981	Folate transport and metabolism	3/1738	31/9376	0.522068376702921	MTHFS/FPGS/ABCC3	-1.27138668469525
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1738	82/9376	0.657891043812625	MGST1/UCKL1/GSTT2B/CMPK1/GSTA1/DUT/NME7/HPRT1/RRM2B/TYMP	-1.48419421071279
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1738	26/9376	0.414977427635656	HES1/MAFA	-1.42486654264724
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1738	26/9376	0.414977427635656	SLC19A2/LMBRD1	-1.42486654264724
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1738	79/9376	0.614586823207237	STX2/STXBP1/ATP6V1E2/ATP6V1D/CACNA1A/AP2A1/SLC1A3/ATP6V1G1/ATP6V0A2	-1.64092747213393
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1738	17/9376	0.317335679956678	HSD17B4	-1.34380928965636
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1738	17/9376	0.317335679956678	CSAD	-1.34380928965636
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1738	17/9376	0.317335679956678	TFRC	-1.34380928965636
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1738	35/9376	0.462403419365445	ALDOA/PFKP/HK2	-1.51989830653905
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/1738	36/9376	0.449558879938627	GALNT15/C1GALT1C1/GALNT2	-1.57837204140097
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1738	18/9376	0.299705919959085	ACACB	-1.4185540382046
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1738	18/9376	0.299705919959085	ENGASE	-1.4185540382046
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1738	45/9376	0.479529471934535	FAS/IL6/HLA-F/IL1A	-1.66939459013453
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/1738	250/9376	0.755258918296893	NCOA7/IDS/ABCA5/AP3S1/AP1G1/ARSB/DEPTOR/SLC36A4/SPG11/OSBP/LAMTOR3/ATP6V1E2/GALNS/AP5B1/VPS29/ATP6V1D/VPS13C/ARL8A/ENTPD4/BLOC1S4/PIKFYVE/BLOC1S2/SLC38A9/AP2A1/AP4M1/DMXL1/ARL8B/LAPTM4A/KXD1/VPS26A/ATP6V1G1/ATP6V0A2/CD164/OSTM1/AP5M1	-1.87092916285897
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1738	37/9376	0.437408639940286	COMT/MAOB/MIF	-1.63555227632557
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1738	29/9376	0.37204872822507	GNGT1/CALM2	-1.6155095109923
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1738	191/9376	0.706113423987372	FOSB/PPP1CB/MAOB/GNAI1/SHC2/ATF2/RAF1/SOS2/GNG4/BRAF/SOS1/GNB5/MAP2K1/HAT1/GNG5/GNGT1/ADORA2B/GNG12/CALM2/CREB3L2/ARAF/GNB2/GNAI3/HDAC4/ATF4	-1.95739083091612
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1738	30/9376	0.359647103950901	PLA2G4A/PLA2G5	-1.67566737560945
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1738	63/9376	0.513781577072716	PLA2G4A/PLA2G5/PTGIS/PTGR1/PTGES3/CYP4F8	-1.8470454441537
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	20/1738	160/9376	0.67433831990794	NEGR1/F11R/ITGB8/NFASC/CLDN23/NECTIN3/NCAM2/PVR/NRCAM/SDC4/HLA-F/NRXN2/ITGAV/OCLN/NECTIN1/CLDN12/CLDN15/SDC2/CADM1/CD58	-1.98187433935336
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	23/1738	183/9376	0.678023228759896	REXO2/SBDS/NXT1/NXF1/AK6/EFL1/FCF1/XRN1/NMD3/CSNK2A2/XPO1/CSNK2B/CSNK2A1/WDR36/RPP30/BMS1/RCL1/UTP6/GNL3/RIOK2/NOB1/NOP56/HEATR1	-2.09817714981805
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1738	66/9376	0.490427869023956	HSD11B1/COMT/CYP3A5/HSD17B6/HSD17B7/HSD17B2	-1.98163421631839
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1738	23/9376	0.234552459098414	MME	-1.75317221935804
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1738	44/9376	0.367820901767967	FAS/HLA-F/IL1A	-2.00493271807471
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/1738	298/9376	0.724121685807184	PRL/IL11/FAS/IL10RB/IL15RA/TNFRSF12A/GDF5/IL18R1/IL1R1/EPOR/IFNGR2/IL1RAP/BMP2/CLCF1/TGFB2/CSF3/IFNGR1/ACVR1B/TNFRSF10D/TGFB3/IL1RL1/IL15/OSMR/LEPR/BMPR1A/BMP6/IL4R/TGFBR1/GDF6/IL6/LIF/IL1A/AMH/RELT/ACVR2B/CSF1/ACKR3/CXCL1/INHBB/RELL1	-2.30861388602489
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1738	70/9376	0.462403419365445	MGST1/HSD11B1/GSTT2B/GSTA1/CYP3A5/SULT1A1	-2.15349908159571
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1738	36/9376	0.299705919959085	UGDH/UGP2	-2.00807053908319
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1738	46/9376	0.351828688647621	CPOX/FTH1/EARS2	-2.10207688228721
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1738	38/9376	0.283931924171764	TAP2/TAP1	-2.10979312565557
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	23/1738	195/9376	0.636298722374672	PLCG2/AKT1/PLCB1/FGG/RAF1/MAPK14/CASP1/MAP2K1/PIK3CA/HAT1/MAP3K7/ACTB/VDAC2/RELA/PLCB3/PRKCA/VDAC1/CASP4/AKT3/PIK3R2/CLCN3/VDAC3/HDAC4	-2.44814894050488
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1738	39/9376	0.27665161842377	FAS/HLA-F	-2.15921970760655
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1738	50/9376	0.323682393555811	IL15RA/IL15/IL6	-2.28722393609769
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1738	68/9376	0.396669599945847	ALDH1A2/RDH10/CYP3A5/HSD17B6/CYP2W1	-2.38178291129786
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1738	41/9376	0.26315641752505	GABRE/CACNA1A	-2.25543735925498
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1738	87/9376	0.434056849595916	COX7A1/CACNA2D1/CACNB2/ATP1B1/ATP2A2/COX7A2L/ACTC1	-2.52969784123992
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1738	31/9376	0.174022792234307	UGDH	-2.19725243659449
NA	NA	hsa04082	Neuroactive ligand signaling	22/1738	199/9376	0.596399720119585	P2RX2/ADRA2C/ADCY9/GNAI1/PLCB1/GNG4/SLC17A9/GABRE/HTR2B/GNB5/OGFR/GNG5/GNGT1/PLCB3/ADORA2B/GNG12/PRKCA/SLC1A3/GNB2/GNAI3/GNA11/ADCY6	-2.74503779448377
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1738	73/9376	0.369500449264625	MGST1/GSTT2B/MAOB/GSTA1/CYP3A5	-2.57961799753143
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1738	86/9376	0.376374876227688	P2RX2/PLCB1/PLCB3/CACNA1A/ADCY6/ITPR3	-2.77131357427129
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1738	79/9376	0.34143712400402	MGST1/HSD11B1/GSTT2B/GSTA1/CYP3A5	-2.80388419602582
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/1738	100/9376	0.377629459148447	IL10RB/IL18R1/TNFRSF10D/IL6/CSF1/ACKR3/CXCL1	-2.98462213075827
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1738	54/9376	0.19980394663939	FAS/HLA-F	-2.81293329080524
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1738	90/9376	0.299705919959085	ADCY9/ATP1B1/ABCC3/ADCY6/LDLR	-3.18425667103883
NA	NA	hsa04382	Cornified envelope formation	20/1738	217/9376	0.497207977812306	ABHD5/UGCG/SPTLC1/PPP2CB/CLDN23/PPP2R2D/PPP2R1B/COL4A6/LAMA5/PPP2R3C/KRT10/KDSR/COL4A1/OCLN/PPP2R3A/CLDN12/PPP2CA/CLDN15/PCSK6/KAZN	-3.57449680125498
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1738	99/9376	0.272459927235531	CFH/CFB/FGG/KRT10/C1S	-3.4712943018515
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	30/1738	370/9376	0.437408639940286	PRL/P2RX2/ADRA2C/ADM/PTGER2/F2R/THRB/PGRMC2/RXFP1/LYPD6/CYSLTR2/PGRMC1/BDKRB1/PTGIR/GABRE/HTR2B/LEPR/OGFR/LPAR1/GAL/UCN/PTGFR/ADORA2B/CNR1/S1PR3/OXTR/HCRTR2/EDNRB/PTH1R/SSTR2	-5.26682206330125
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/1738	143/9376	0.075450441388301	TRIM21/C1S	-5.31431745512663
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1738	449/9376	0.072089619945615	CAMK2D/PRKG1/OR4D9/CALM2/OR10K1/OR52H1	-9.61163197096494