ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 174/3713 495/18639 0.351515151515152 1.76458144602502 7.99002371844131e-16 1.05228612371872e-12 GO:0019787 ubiquitin-like protein transferase activity 165/3713 479/18639 0.34446764091858 1.7292034363268 3.48591314023341e-14 2.2954738028437e-11 GO:0140297 DNA-binding transcription factor binding 165/3713 488/18639 0.338114754098361 1.69731238934537 2.15115376782889e-13 9.44356504076881e-11 GO:0016755 aminoacyltransferase activity 166/3713 496/18639 0.334677419354839 1.68005720962964 4.85223804161805e-13 1.59759937520274e-10 GO:0004842 ubiquitin-protein transferase activity 151/3713 449/18639 0.33630289532294 1.68821698516679 3.64969279680308e-12 9.61329082677932e-10 GO:0003714 transcription corepressor activity 82/3713 204/18639 0.401960784313726 2.01781499025681 1.96051820899604e-11 4.30333746874631e-09 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 120/3713 349/18639 0.343839541547278 1.72605042146505 1.25580884788086e-10 2.36271464665585e-08 GO:0046332 SMAD binding 39/3713 79/18639 0.493670886075949 2.47819327917307 4.23793216519507e-09 6.97669582695239e-07 GO:0044389 ubiquitin-like protein ligase binding 108/3713 322/18639 0.335403726708075 1.68370322168376 5.06149814480137e-09 7.40665895189267e-07 GO:0061659 ubiquitin-like protein ligase activity 118/3713 372/18639 0.317204301075269 1.59234337940801 3.70911609137795e-08 4.40715187471941e-06 GO:0031625 ubiquitin protein ligase binding 100/3713 302/18639 0.33112582781457 1.66222846879498 3.84584905540727e-08 4.40715187471941e-06 GO:0032182 ubiquitin-like protein binding 50/3713 120/18639 0.416666666666667 2.09163748990035 4.01562813186279e-08 4.40715187471941e-06 GO:0061630 ubiquitin protein ligase activity 110/3713 353/18639 0.311614730878187 1.56428412842406 2.91413301414235e-07 2.95224090740421e-05 GO:0005160 transforming growth factor beta receptor binding 17/3713 26/18639 0.653846153846154 3.28226190722824 5.77236632623381e-07 5.43014746546423e-05 GO:0003713 transcription coactivator activity 84/3713 256/18639 0.328125 1.64716452329653 7.02189548453778e-07 6.16522423542417e-05 GO:0004674 protein serine/threonine kinase activity 128/3713 433/18639 0.295612009237875 1.4839515863681 8.25718467617126e-07 6.79669513657346e-05 GO:0070411 I-SMAD binding 12/3713 16/18639 0.75 3.76494748182063 3.12105885057613e-06 0.000241790265071104 GO:0003924 GTPase activity 100/3713 331/18639 0.302114803625378 1.51659515884013 4.56368384444602e-06 0.000333909534618634 GO:0106310 protein serine kinase activity 107/3713 361/18639 0.296398891966759 1.48790168256623 5.60887539698669e-06 0.000388783626201657 GO:0061650 ubiquitin-like protein conjugating enzyme activity 21/3713 41/18639 0.51219512195122 2.57118364612141 7.62792765530823e-06 0.000502299036102047 GO:0043021 ribonucleoprotein complex binding 60/3713 177/18639 0.338983050847458 1.70167117822401 8.39378931357505e-06 0.000526410501237064 GO:0035925 mRNA 3'-UTR AU-rich region binding 17/3713 30/18639 0.566666666666667 2.84462698626448 9.71434256071997e-06 0.000581535870566736 GO:0016922 nuclear receptor binding 49/3713 137/18639 0.357664233576642 1.79544940738891 1.07554807128225e-05 0.000615868178208143 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 23/3713 48/18639 0.479166666666667 2.4053831133854 1.19248656263763e-05 0.000654377001247402 GO:0019887 protein kinase regulator activity 79/3713 255/18639 0.309803921568627 1.55519399249061 1.64468954424315e-05 0.000866422451907293 GO:0005525 GTP binding 109/3713 378/18639 0.288359788359788 1.44754594539135 1.75720508507866e-05 0.000890091960403305 GO:0043130 ubiquitin binding 38/3713 100/18639 0.38 1.90757339078912 2.15496575148214e-05 0.00105114440544518 GO:0070412 R-SMAD binding 15/3713 26/18639 0.576923076923077 2.89611344755433 2.44695006503212e-05 0.00115094044130261 GO:0019207 kinase regulator activity 86/3713 287/18639 0.299651567944251 1.50422988820708 2.87336617076301e-05 0.00130490456789479 GO:0061631 ubiquitin conjugating enzyme activity 18/3713 35/18639 0.514285714285714 2.58167827324843 3.1737728138492e-05 0.0013932862652798 GO:0060589 nucleoside-triphosphatase regulator activity 134/3713 490/18639 0.273469387755102 1.3727971770448 3.64474030581211e-05 0.0015484267686305 GO:0051082 unfolded protein binding 43/3713 121/18639 0.355371900826446 1.78394205750179 4.32293699525665e-05 0.00177915875711032 GO:0031624 ubiquitin conjugating enzyme binding 16/3713 30/18639 0.533333333333333 2.67729598707245 4.89967513918247e-05 0.00183981733090444 GO:0044183 protein folding chaperone 30/3713 75/18639 0.4 2.00797199030434 5.03956000018082e-05 0.00183981733090444 GO:0003727 single-stranded RNA binding 34/3713 89/18639 0.382022471910112 1.91772605815583 5.04328131119141e-05 0.00183981733090444 GO:0030695 GTPase regulator activity 133/3713 489/18639 0.2719836400818 1.36533882776317 5.11893235139496e-05 0.00183981733090444 GO:0044390 ubiquitin-like protein conjugating enzyme binding 18/3713 36/18639 0.5 2.50996498788042 5.16881102835719e-05 0.00183981733090444 GO:0019001 guanyl nucleotide binding 111/3713 400/18639 0.2775 1.39303056827363 8.67443593879813e-05 0.00292929029010183 GO:0032561 guanyl ribonucleotide binding 111/3713 400/18639 0.2775 1.39303056827363 8.67443593879813e-05 0.00292929029010183 GO:0016779 nucleotidyltransferase activity 46/3713 136/18639 0.338235294117647 1.69791749180146 9.55695503270431e-05 0.00314662744451789 GO:0003725 double-stranded RNA binding 29/3713 75/18639 0.386666666666667 1.94103959062752 0.00013673683155005 0.00439225383296137 GO:0140030 modification-dependent protein binding 55/3713 173/18639 0.317919075144509 1.59593149518408 0.000141081785427656 0.00442392170019577 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 9/3713 13/18639 0.692307692307692 3.4753361370652 0.000159737362225538 0.00483931338665219 GO:0005096 GTPase activator activity 79/3713 271/18639 0.291512915129151 1.46337442097825 0.000161677895985343 0.00483931338665219 GO:0035173 histone kinase activity 100/3713 360/18639 0.277777777777778 1.3944249932669 0.00018176968862027 0.00531979288695325 GO:0070063 RNA polymerase binding 24/3713 59/18639 0.406779661016949 2.04200541386882 0.000204005646500891 0.00572080176727446 GO:0000993 RNA polymerase II complex binding 17/3713 36/18639 0.472222222222222 2.37052248855373 0.000204159212651404 0.00572080176727446 GO:0015036 disulfide oxidoreductase activity 18/3713 40/18639 0.45 2.25896848909238 0.000284522367904932 0.00755220377582112 GO:0140662 ATP-dependent protein folding chaperone 18/3713 40/18639 0.45 2.25896848909238 0.000284522367904932 0.00755220377582112 GO:0000287 magnesium ion binding 68/3713 230/18639 0.295652173913043 1.48415321022494 0.000286719961116975 0.00755220377582112 GO:0019783 ubiquitin-like protein peptidase activity 42/3713 127/18639 0.330708661417323 1.66013432269256 0.000325737583606922 0.00811811648604946 GO:0015035 protein-disulfide reductase activity 16/3713 34/18639 0.470588235294118 2.36231998859334 0.000328846305687943 0.00811811648604946 GO:0140996 histone H3 kinase activity 98/3713 357/18639 0.274509803921569 1.37801999334611 0.000330870801111494 0.00811811648604946 GO:0140517 protein-RNA adaptor activity 12/3713 22/18639 0.545454545454545 2.73814362314228 0.000332861268220707 0.00811811648604946 GO:0043022 ribosome binding 38/3713 112/18639 0.339285714285714 1.70319052749028 0.000346235622066023 0.00827495398205548 GO:0019003 GDP binding 28/3713 75/18639 0.373333333333333 1.87410719095071 0.000351858331811015 0.00827495398205548 GO:0141003 histone H2AX kinase activity 97/3713 354/18639 0.274011299435028 1.37551753573108 0.000378723717679127 0.00875051116111246 GO:0070717 poly-purine tract binding 15/3713 32/18639 0.46875 2.35309217613789 0.000530343743323917 0.0120424605165103 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 12/3713 23/18639 0.521739130434783 2.61909390039696 0.000570206931489056 0.012392078416945 GO:0019902 phosphatase binding 57/3713 190/18639 0.3 1.50597899272825 0.000572795273532599 0.012392078416945 GO:0097602 cullin family protein binding 13/3713 26/18639 0.5 2.50996498788042 0.000573968704201707 0.012392078416945 GO:0001221 transcription coregulator binding 38/3713 115/18639 0.330434782608696 1.65875947025141 0.000622357671928788 0.0132200815150034 GO:0140098 catalytic activity, acting on RNA 103/3713 387/18639 0.266149870801034 1.33605371447898 0.000775799076050223 0.0162178949707642 GO:0140416 transcription regulator inhibitor activity 15/3713 33/18639 0.454545454545455 2.28178635261856 0.000794518418811879 0.0163496993371132 GO:0019209 kinase activator activity 46/3713 148/18639 0.310810810810811 1.56024850597972 0.000817919995621983 0.0165723174497562 GO:0070566 adenylyltransferase activity 14/3713 30/18639 0.466666666666667 2.34263398868839 0.000856503492830359 0.0170911378796604 GO:1990841 promoter-specific chromatin binding 25/3713 68/18639 0.367647058823529 1.84556249108854 0.000926147631280161 0.0180757124903392 GO:0004532 RNA exonuclease activity 17/3713 40/18639 0.425 2.13347023969836 0.000933294190845154 0.0180757124903392 GO:0004679 AMP-activated protein kinase activity 70/3713 248/18639 0.282258064516129 1.41691571896475 0.000983991804222916 0.0187814087849504 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 124/3713 484/18639 0.256198347107438 1.28609776238501 0.00118694088835435 0.0222118089996414 GO:0031994 insulin-like growth factor I binding 8/3713 13/18639 0.615384615384615 3.08918767739129 0.00120650672202785 0.0222118089996414 GO:0004860 protein kinase inhibitor activity 29/3713 84/18639 0.345238095238095 1.73307106306029 0.00121431302048154 0.0222118089996414 GO:0101005 deubiquitinase activity 37/3713 115/18639 0.321739130434783 1.61510790524479 0.00126736777724364 0.022695675562655 GO:0140857 histone H3T45 kinase activity 69/3713 246/18639 0.280487804878049 1.40802913954267 0.00127523158058958 0.022695675562655 GO:0030295 protein kinase activator activity 43/3713 139/18639 0.309352517985612 1.55292797811307 0.00131656519970837 0.023118884906879 GO:0005521 lamin binding 9/3713 16/18639 0.5625 2.82371061136547 0.00142534884817185 0.0235260272135597 GO:0035403 histone H3T6 kinase activity 69/3713 247/18639 0.279352226720648 1.40232861671052 0.00143093618103687 0.0235260272135597 GO:0001216 DNA-binding transcription activator activity 125/3713 491/18639 0.254582484725051 1.27798624637496 0.00145826593928528 0.0235260272135597 GO:0004843 cysteine-type deubiquitinase activity 35/3713 108/18639 0.324074074074074 1.62682915881138 0.00146755654375223 0.0235260272135597 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 16/3713 38/18639 0.421052631578947 2.11365472663614 0.00147566850123824 0.0235260272135597 GO:0003756 protein disulfide isomerase activity 10/3713 19/18639 0.526315789473684 2.64206840829518 0.00152042316665929 0.0235260272135597 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 10/3713 19/18639 0.526315789473684 2.64206840829518 0.00152042316665929 0.0235260272135597 GO:0043175 RNA polymerase core enzyme binding 17/3713 42/18639 0.404761904761905 2.03187641876034 0.00178539767009616 0.0235260272135597 GO:0001222 transcription corepressor binding 19/3713 49/18639 0.387755102040816 1.9465034599889 0.00179574211605427 0.0235260272135597 GO:0016763 pentosyltransferase activity 19/3713 49/18639 0.387755102040816 1.9465034599889 0.00179574211605427 0.0235260272135597 GO:0004676 3-phosphoinositide-dependent protein kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0004711 ribosomal protein S6 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0035175 histone H3S10 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0035979 histone H2AXS139 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0044022 histone H3S28 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0044023 histone H4S1 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0044024 histone H2AS1 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0044025 histone H2BS14 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0072354 histone H3T3 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0072371 histone H2AS121 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0072518 Rho-dependent protein serine/threonine kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0140823 histone H2BS36 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0140855 histone H3S57 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0140995 histone H2A kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0140997 histone H4 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0140998 histone H2B kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:1990244 histone H2AT120 kinase activity 68/3713 245/18639 0.277551020408163 1.39328668714995 0.0018437458605954 0.0235260272135597 GO:0001098 basal transcription machinery binding 22/3713 60/18639 0.366666666666667 1.84064099111231 0.00190628201597317 0.0235260272135597 GO:0001099 basal RNA polymerase II transcription machinery binding 22/3713 60/18639 0.366666666666667 1.84064099111231 0.00190628201597317 0.0235260272135597 GO:0098531 ligand-modulated transcription factor activity 22/3713 60/18639 0.366666666666667 1.84064099111231 0.00190628201597317 0.0235260272135597 GO:0005114 type II transforming growth factor beta receptor binding 7/3713 11/18639 0.636363636363636 3.19450089366599 0.0019113780651867 0.0235260272135597 GO:0180030 inositol phosphate kinase activity 7/3713 11/18639 0.636363636363636 3.19450089366599 0.0019113780651867 0.0235260272135597 GO:0016860 intramolecular oxidoreductase activity 20/3713 53/18639 0.377358490566038 1.89431319840032 0.00202399227606322 0.0246814613664376 GO:0004677 DNA-dependent protein kinase activity 68/3713 246/18639 0.276422764227642 1.38762292012901 0.00206093109115945 0.0249013417161192 GO:0030165 PDZ domain binding 28/3713 83/18639 0.337349397590361 1.69347035326872 0.0021650811628323 0.0259219262859104 GO:0035402 histone H3T11 kinase activity 68/3713 247/18639 0.275303643724696 1.38200501356979 0.00230025876651326 0.0272922594189006 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 67/3713 243/18639 0.275720164609054 1.3840959192427 0.00236717690153057 0.0278354641010336 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 11/3713 23/18639 0.478260869565217 2.40083607536388 0.0024030054875824 0.0280067099747435 GO:0003925 G protein activity 20/3713 54/18639 0.37037037037037 1.85923332435587 0.00262129821156541 0.0300195629967969 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 20/3713 54/18639 0.37037037037037 1.85923332435587 0.00262129821156541 0.0300195629967969 GO:0043539 protein serine/threonine kinase activator activity 25/3713 73/18639 0.342465753424658 1.71915410128796 0.00289574400608223 0.0328766797931922 GO:0051219 phosphoprotein binding 30/3713 93/18639 0.32258064516129 1.61933225024543 0.00332892058716529 0.0374716958401427 GO:0004879 nuclear receptor activity 21/3713 59/18639 0.355932203389831 1.78675473713521 0.00361597827012711 0.0398237081824402 GO:0031593 polyubiquitin modification-dependent protein binding 21/3713 59/18639 0.355932203389831 1.78675473713521 0.00361597827012711 0.0398237081824402 GO:0042393 histone binding 67/3713 247/18639 0.271255060728745 1.36168141042905 0.00362858388906061 0.0398237081824402 GO:0070410 co-SMAD binding 7/3713 12/18639 0.583333333333333 2.92829248586049 0.00380003000943877 0.0406881261986248 GO:1990247 N6-methyladenosine-containing RNA reader activity 7/3713 12/18639 0.583333333333333 2.92829248586049 0.00380003000943877 0.0406881261986248 GO:1990817 poly(A) RNA polymerase activity 7/3713 12/18639 0.583333333333333 2.92829248586049 0.00380003000943877 0.0406881261986248 GO:0051087 protein-folding chaperone binding 40/3713 134/18639 0.298507462686567 1.49848655992861 0.00386584705306637 0.04075675758016 GO:0019210 kinase inhibitor activity 29/3713 90/18639 0.322222222222222 1.6175329921896 0.00392572703805574 0.04075675758016 GO:0009931 calcium-dependent protein serine/threonine kinase activity 10/3713 21/18639 0.476190476190476 2.3904428456004 0.00393022643331839 0.04075675758016 GO:0035613 RNA stem-loop binding 10/3713 21/18639 0.476190476190476 2.3904428456004 0.00393022643331839 0.04075675758016 GO:0008308 voltage-gated monoatomic anion channel activity 9/3713 18/18639 0.5 2.50996498788042 0.00411583555378279 0.0423480892525932 GO:0031267 small GTPase binding 75/3713 283/18639 0.265017667844523 1.33037013491895 0.0041687370166937 0.0425598965192682 GO:0005109 frizzled binding 15/3713 38/18639 0.394736842105263 1.98155130622138 0.00433832451478051 0.0439505645074303 GO:0060590 ATPase regulator activity 18/3713 49/18639 0.36734693877551 1.84405590946317 0.00464867664492648 0.0467351690180777 GO:0035198 miRNA binding 16/3713 42/18639 0.380952380952381 1.91235427648032 0.00493588571973681 0.0490109290373897 GO:0019903 protein phosphatase binding 42/3713 144/18639 0.291666666666667 1.46414624293024 0.00494947119360124 0.0490109290373897 GO:0000175 3'-5'-RNA exonuclease activity 14/3713 35/18639 0.4 2.00797199030434 0.00502611347918556 0.0493984436722939 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 38/3713 128/18639 0.296875 1.490291711554 0.00528119403376191 0.0515209817960329 GO:0000049 tRNA binding 26/3713 80/18639 0.325 1.63147724212227 0.00538375654156988 0.0521353482738789 GO:0030291 protein serine/threonine kinase inhibitor activity 17/3713 46/18639 0.369565217391304 1.85519151278118 0.00546823234062543 0.0525668758584211 GO:0008140 cAMP response element binding protein binding 6/3713 10/18639 0.6 3.0119579854565 0.00622530606596257 0.058983655315631 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 6/3713 10/18639 0.6 3.0119579854565 0.00622530606596257 0.058983655315631 GO:0140597 protein carrier chaperone 52/3713 188/18639 0.276595744680851 1.3884912698913 0.00633441833501884 0.0595887781944273 GO:0005520 insulin-like growth factor binding 9/3713 19/18639 0.473684210526316 2.37786156746566 0.00645170670219393 0.0602616860055986 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 12/3713 29/18639 0.413793103448276 2.07721240376311 0.00667467015722522 0.0607404598212008 GO:0097472 cyclin-dependent protein kinase activity 12/3713 29/18639 0.413793103448276 2.07721240376311 0.00667467015722522 0.0607404598212008 GO:0061980 regulatory RNA binding 20/3713 58/18639 0.344827586206897 1.73101033646926 0.00667760785080785 0.0607404598212008 GO:0055106 ubiquitin-protein transferase regulator activity 14/3713 36/18639 0.388888888888889 1.95219499057366 0.00674079681455406 0.0607404598212008 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 8/3713 16/18639 0.5 2.50996498788042 0.00680641865799081 0.0607404598212008 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 7/3713 13/18639 0.538461538461538 2.70303921771738 0.00682580717808483 0.0607404598212008 GO:0140852 histone ubiquitin ligase activity 7/3713 13/18639 0.538461538461538 2.70303921771738 0.00682580717808483 0.0607404598212008 GO:0071889 14-3-3 protein binding 13/3713 33/18639 0.393939393939394 1.97754817226942 0.00785895597330306 0.0694647316566451 GO:0031072 heat shock protein binding 38/3713 131/18639 0.290076335877863 1.45616289373215 0.00797592919935055 0.0700286583702978 GO:0140789 histone phosphatase activity 39/3713 136/18639 0.286764705882353 1.43953874304906 0.00889635953609171 0.0771689141068651 GO:0008187 poly-pyrimidine tract binding 12/3713 30/18639 0.4 2.00797199030434 0.00914073697848971 0.0771689141068651 GO:0043995 histone H4K5 acetyltransferase activity 12/3713 30/18639 0.4 2.00797199030434 0.00914073697848971 0.0771689141068651 GO:0043996 histone H4K8 acetyltransferase activity 12/3713 30/18639 0.4 2.00797199030434 0.00914073697848971 0.0771689141068651 GO:0043997 histone H4K12 acetyltransferase activity 12/3713 30/18639 0.4 2.00797199030434 0.00914073697848971 0.0771689141068651 GO:0051721 protein phosphatase 2A binding 12/3713 30/18639 0.4 2.00797199030434 0.00914073697848971 0.0771689141068651 GO:0008266 poly(U) RNA binding 11/3713 27/18639 0.407407407407407 2.04515665679145 0.0105958209290383 0.0886723704984242 GO:0032183 SUMO binding 8/3713 17/18639 0.470588235294118 2.36231998859334 0.0106379912974571 0.0886723704984242 GO:0140034 methylation-dependent protein binding 24/3713 76/18639 0.315789473684211 1.58524104497711 0.0107446040692918 0.088997758234323 GO:0008174 mRNA methyltransferase activity 7/3713 14/18639 0.5 2.50996498788042 0.0113270400141404 0.09100884788666 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 6/3713 11/18639 0.545454545454545 2.73814362314228 0.0114020196668936 0.09100884788666 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 6/3713 11/18639 0.545454545454545 2.73814362314228 0.0114020196668936 0.09100884788666 GO:0032404 mismatch repair complex binding 6/3713 11/18639 0.545454545454545 2.73814362314228 0.0114020196668936 0.09100884788666 GO:0034713 type I transforming growth factor beta receptor binding 6/3713 11/18639 0.545454545454545 2.73814362314228 0.0114020196668936 0.09100884788666 GO:0140537 transcription regulator activator activity 6/3713 11/18639 0.545454545454545 2.73814362314228 0.0114020196668936 0.09100884788666 GO:0016791 phosphatase activity 70/3713 273/18639 0.256410256410256 1.28716153224637 0.0121766965841694 0.0963937238307681 GO:0035035 histone acetyltransferase binding 10/3713 24/18639 0.416666666666667 2.09163748990035 0.0122230462260731 0.0963937238307681 GO:0051879 Hsp90 protein binding 15/3713 42/18639 0.357142857142857 1.7928321342003 0.0124582336458863 0.0976636530454301 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 35/3713 122/18639 0.286885245901639 1.44014384550516 0.0126069426720073 0.0982446360889563 GO:0003724 RNA helicase activity 24/3713 77/18639 0.311688311688312 1.56465349893844 0.0127290712227716 0.098612863531707 GO:0140767 enzyme-substrate adaptor activity 39/3713 139/18639 0.280575539568345 1.40846956154441 0.0129097527529612 0.0994277448868412 GO:0005085 guanyl-nucleotide exchange factor activity 60/3713 230/18639 0.260869565217391 1.30954695019848 0.0134006837229376 0.102608723622726 GO:0010485 histone H4 acetyltransferase activity 13/3713 35/18639 0.371428571428571 1.86454541956831 0.0136477266605898 0.10329917248274 GO:0140566 histone reader activity 13/3713 35/18639 0.371428571428571 1.86454541956831 0.0136477266605898 0.10329917248274 GO:0042826 histone deacetylase binding 36/3713 127/18639 0.283464566929134 1.42297227659362 0.0139708803886532 0.104554722750179 GO:0051020 GTPase binding 79/3713 315/18639 0.250793650793651 1.25896656534954 0.0141936364239768 0.104554722750179 GO:0004725 protein tyrosine phosphatase activity 29/3713 98/18639 0.295918367346939 1.48548948262311 0.0141988640170978 0.104554722750179 GO:0019789 SUMO transferase activity 11/3713 28/18639 0.392857142857143 1.97211534762033 0.0143693278798651 0.104554722750179 GO:0036408 histone H3K14 acetyltransferase activity 11/3713 28/18639 0.392857142857143 1.97211534762033 0.0143693278798651 0.104554722750179 GO:0051019 mitogen-activated protein kinase binding 11/3713 28/18639 0.392857142857143 1.97211534762033 0.0143693278798651 0.104554722750179 GO:0051537 2 iron, 2 sulfur cluster binding 11/3713 28/18639 0.392857142857143 1.97211534762033 0.0143693278798651 0.104554722750179 GO:0008408 3'-5' exonuclease activity 19/3713 58/18639 0.327586206896552 1.64445981964579 0.0145751186081869 0.105469402236166 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 25/3713 82/18639 0.304878048780488 1.53046645602465 0.0149043197236701 0.10726223538838 GO:0035064 methylated histone binding 23/3713 74/18639 0.310810810810811 1.56024850597972 0.0150418686433481 0.107663809800486 GO:0045296 cadherin binding 83/3713 334/18639 0.248502994011976 1.24746762870703 0.0153424289107837 0.109221507435146 GO:0004712 protein serine/threonine/tyrosine kinase activity 15/3713 43/18639 0.348837209302326 1.7511383636375 0.015686734260954 0.110781950446381 GO:0004721 phosphoprotein phosphatase activity 47/3713 175/18639 0.268571428571429 1.34820976491863 0.0157298593268589 0.110781950446381 GO:0031690 adrenergic receptor binding 8/3713 18/18639 0.444444444444444 2.23107998922704 0.0158557158923966 0.111074350161097 GO:0043425 bHLH transcription factor binding 12/3713 32/18639 0.375 1.88247374091032 0.0161335098097418 0.112422393753597 GO:0017056 structural constituent of nuclear pore 10/3713 25/18639 0.4 2.00797199030434 0.0168039159671365 0.116477670151151 GO:0003743 translation initiation factor activity 17/3713 51/18639 0.333333333333333 1.67330999192028 0.0169301298374847 0.116738120397735 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 25/3713 83/18639 0.301204819277108 1.51202710113278 0.0173931685475072 0.117906943629242 GO:0008135 translation factor activity, RNA binding 25/3713 83/18639 0.301204819277108 1.51202710113278 0.0173931685475072 0.117906943629242 GO:0008186 ATP-dependent activity, acting on RNA 24/3713 79/18639 0.30379746835443 1.52504201795266 0.0175728088130969 0.117906943629242 GO:0000774 adenyl-nucleotide exchange factor activity 7/3713 15/18639 0.466666666666667 2.34263398868839 0.017636801742567 0.117906943629242 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 7/3713 15/18639 0.466666666666667 2.34263398868839 0.017636801742567 0.117906943629242 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 7/3713 15/18639 0.466666666666667 2.34263398868839 0.017636801742567 0.117906943629242 GO:0035197 siRNA binding 6/3713 12/18639 0.5 2.50996498788042 0.0190040093243485 0.123124126674283 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 6/3713 12/18639 0.5 2.50996498788042 0.0190040093243485 0.123124126674283 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 6/3713 12/18639 0.5 2.50996498788042 0.0190040093243485 0.123124126674283 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 6/3713 12/18639 0.5 2.50996498788042 0.0190040093243485 0.123124126674283 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 6/3713 12/18639 0.5 2.50996498788042 0.0190040093243485 0.123124126674283 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 6/3713 12/18639 0.5 2.50996498788042 0.0190040093243485 0.123124126674283 GO:0010484 histone H3 acetyltransferase activity 11/3713 29/18639 0.379310344827586 1.90411137011618 0.0190716187103673 0.123124126674283 GO:0019208 phosphatase regulator activity 33/3713 117/18639 0.282051282051282 1.41587768547101 0.0193673002990708 0.124423095092079 GO:0001223 transcription coactivator binding 15/3713 44/18639 0.340909090909091 1.71133976446392 0.0195218613795425 0.12459221373866 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 9/3713 22/18639 0.409090909090909 2.05360771735671 0.0195828308609738 0.12459221373866 GO:0180051 translation factor activity 25/3713 84/18639 0.297619047619048 1.49402677850025 0.0201985555920954 0.127891815936489 GO:0008234 cysteine-type peptidase activity 49/3713 187/18639 0.262032085561497 1.31538272092129 0.0217541976900981 0.137082671568704 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 10/3713 26/18639 0.384615384615385 1.93074229836955 0.0225376168029485 0.140673181656318 GO:0008143 poly(A) binding 10/3713 26/18639 0.384615384615385 1.93074229836955 0.0225376168029485 0.140673181656318 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 26/3713 89/18639 0.292134831460674 1.46649639741328 0.0228997623182376 0.141591163970702 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 26/3713 89/18639 0.292134831460674 1.46649639741328 0.0228997623182376 0.141591163970702 GO:0033192 calmodulin-dependent protein phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0140791 histone H2AXS140 phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:1990439 MAP kinase serine/threonine phosphatase activity 24/3713 81/18639 0.296296296296296 1.48738665948469 0.0237597928910593 0.141591163970702 GO:0046915 transition metal ion transmembrane transporter activity 15/3713 45/18639 0.333333333333333 1.67330999192028 0.0240280962135785 0.14254505726704 GO:0097027 ubiquitin-protein transferase activator activity 7/3713 16/18639 0.4375 2.19621936439537 0.0260604330305707 0.153908476687272 GO:0140793 histone H2AXY142 phosphatase activity 26/3713 90/18639 0.288888888888889 1.45020199299758 0.0262683582066678 0.154443873920453 GO:0030332 cyclin binding 12/3713 34/18639 0.352941176470588 1.771739991445 0.0265435061574317 0.155367989374834 GO:0033549 MAP kinase phosphatase activity 24/3713 82/18639 0.292682926829268 1.46924779778366 0.0274241266154963 0.15981227766641 GO:0004722 protein serine/threonine phosphatase activity 29/3713 103/18639 0.281553398058252 1.41337834268995 0.0276878994454793 0.160638606033904 GO:0004402 histone acetyltransferase activity 14/3713 42/18639 0.333333333333333 1.67330999192028 0.0286897626911451 0.165288877798958 GO:0035091 phosphatidylinositol binding 70/3713 284/18639 0.246478873239437 1.2373066841664 0.0287404350918462 0.165288877798958 GO:0035591 signaling adaptor activity 35/3713 129/18639 0.271317829457364 1.36199650505139 0.0289952312143312 0.166029215257714 GO:0004535 poly(A)-specific ribonuclease activity 6/3713 13/18639 0.461538461538462 2.31689075804346 0.0294424683068602 0.167136770517823 GO:0005338 nucleotide-sugar transmembrane transporter activity 6/3713 13/18639 0.461538461538462 2.31689075804346 0.0294424683068602 0.167136770517823 GO:0015605 organophosphate ester transmembrane transporter activity 16/3713 50/18639 0.32 1.60637759224347 0.0295982053845422 0.167299727431082 GO:0004540 RNA nuclease activity 33/3713 121/18639 0.272727272727273 1.36907181157114 0.030981358872778 0.174369442886532 GO:0140104 molecular carrier activity 62/3713 249/18639 0.248995983935743 1.2499424036031 0.0311207931964143 0.174408870807139 GO:0070273 phosphatidylinositol-4-phosphate binding 11/3713 31/18639 0.354838709677419 1.78126547526998 0.0317296021147069 0.177067313496055 GO:0042578 phosphoric ester hydrolase activity 87/3713 363/18639 0.239669421487603 1.20312371319888 0.0319001756728082 0.177268064814719 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 5/3713 10/18639 0.5 2.50996498788042 0.0322331263657858 0.177619361605606 GO:0008641 ubiquitin-like modifier activating enzyme activity 5/3713 10/18639 0.5 2.50996498788042 0.0322331263657858 0.177619361605606 GO:0016407 acetyltransferase activity 27/3713 96/18639 0.28125 1.41185530568274 0.0331830035063067 0.182091731740858 GO:0016776 phosphotransferase activity, phosphate group as acceptor 13/3713 39/18639 0.333333333333333 1.67330999192028 0.0343168672372554 0.187532423865002 GO:0045309 protein phosphorylated amino acid binding 18/3713 59/18639 0.305084745762712 1.53150406040161 0.0350048875626785 0.190501805454742 GO:0050431 transforming growth factor beta binding 9/3713 24/18639 0.375 1.88247374091032 0.0352448848410553 0.191018573397818 GO:0004527 exonuclease activity 24/3713 84/18639 0.285714285714286 1.43426570736024 0.0360269006364572 0.192875724139082 GO:0017018 myosin phosphatase activity 24/3713 84/18639 0.285714285714286 1.43426570736024 0.0360269006364572 0.192875724139082 GO:0051117 ATPase binding 24/3713 84/18639 0.285714285714286 1.43426570736024 0.0360269006364572 0.192875724139082 GO:0038191 neuropilin binding 7/3713 17/18639 0.411764705882353 2.06702999001917 0.0368561422437503 0.196516353583074 GO:0046966 nuclear thyroid hormone receptor binding 10/3713 28/18639 0.357142857142857 1.7928321342003 0.0380026885729453 0.201812664720036 GO:0005518 collagen binding 21/3713 72/18639 0.291666666666667 1.46414624293024 0.0387329847691653 0.204864823056188 GO:0030145 manganese ion binding 20/3713 68/18639 0.294117647058824 1.47644999287084 0.0395564464078557 0.208383359676584 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 18/3713 60/18639 0.3 1.50597899272825 0.0409873504303017 0.215010726788228 GO:0035401 histone H3Y41 kinase activity 31/3713 115/18639 0.269565217391304 1.3531985152051 0.0413042626252253 0.215010726788228 GO:0140801 histone H2AXY142 kinase activity 31/3713 115/18639 0.269565217391304 1.3531985152051 0.0413042626252253 0.215010726788228 GO:0030331 nuclear estrogen receptor binding 13/3713 40/18639 0.325 1.63147724212227 0.0418520312144992 0.216196214800153 GO:0030159 signaling receptor complex adaptor activity 16/3713 52/18639 0.307692307692308 1.54459383869564 0.0419616873641819 0.216196214800153 GO:0010314 phosphatidylinositol-5-phosphate binding 8/3713 21/18639 0.380952380952381 1.91235427648032 0.0420584680271017 0.216196214800153 GO:0140693 molecular condensate scaffold activity 15/3713 48/18639 0.3125 1.56872811742526 0.0421886311341224 0.216196214800153 GO:0008195 phosphatidate phosphatase activity 6/3713 14/18639 0.428571428571429 2.15139856104036 0.0430290395264 0.218800173962428 GO:0042813 Wnt receptor activity 6/3713 14/18639 0.428571428571429 2.15139856104036 0.0430290395264 0.218800173962428 GO:0019888 protein phosphatase regulator activity 29/3713 107/18639 0.271028037383178 1.36054176913144 0.0442845662666006 0.224318360665819 GO:0140713 histone chaperone activity 42/3713 164/18639 0.25609756097561 1.2855918230607 0.0445216422088064 0.224655183099609 GO:0017025 TBP-class protein binding 9/3713 25/18639 0.36 1.8071747912739 0.0456179298326347 0.228436553572547 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 9/3713 25/18639 0.36 1.8071747912739 0.0456179298326347 0.228436553572547 GO:0015932 nucleobase-containing compound transmembrane transporter activity 17/3713 57/18639 0.298245614035088 1.49717209803393 0.048580550450933 0.241610471979775 GO:0001217 DNA-binding transcription repressor activity 67/3713 278/18639 0.241007194244604 1.2098392387625 0.0486156226838576 0.241610471979775 GO:0034212 protein N-acetyltransferase activity 16/3713 53/18639 0.30188679245283 1.51545055872025 0.0493612913302795 0.242270350722058 GO:0043522 leucine zipper domain binding 5/3713 11/18639 0.454545454545455 2.28178635261856 0.049592381948196 0.242270350722058 GO:0070697 activin receptor binding 5/3713 11/18639 0.454545454545455 2.28178635261856 0.049592381948196 0.242270350722058 GO:0070990 snRNP binding 5/3713 11/18639 0.454545454545455 2.28178635261856 0.049592381948196 0.242270350722058 GO:0140674 ATP-dependent histone chaperone activity 39/3713 152/18639 0.256578947368421 1.2880083490439 0.0499911359618685 0.242270350722058 GO:0070628 proteasome binding 7/3713 18/18639 0.388888888888889 1.95219499057366 0.0502200499218845 0.242270350722058 GO:0098641 cadherin binding involved in cell-cell adhesion 7/3713 18/18639 0.388888888888889 1.95219499057366 0.0502200499218845 0.242270350722058 GO:1990381 ubiquitin-specific protease binding 7/3713 18/18639 0.388888888888889 1.95219499057366 0.0502200499218845 0.242270350722058 GO:0070851 growth factor receptor binding 36/3713 139/18639 0.258992805755396 1.30012574911792 0.0512432089654025 0.246304037253413 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 56/3713 229/18639 0.244541484716157 1.2275811294437 0.0525625188889152 0.251726681369823 GO:0061775 cohesin loader activity 39/3713 153/18639 0.254901960784314 1.27958999382139 0.0546121251191289 0.260594814427148 GO:0016853 isomerase activity 45/3713 180/18639 0.25 1.25498249394021 0.0554028639552673 0.263413616711506 GO:0140463 chromatin-protein adaptor activity 16/3713 54/18639 0.296296296296296 1.48738665948469 0.0576289082730197 0.273011770487651 GO:0033130 acetylcholine receptor binding 6/3713 15/18639 0.4 2.00797199030434 0.0599571980489553 0.282012963680265 GO:0120283 protein serine/threonine kinase binding 6/3713 15/18639 0.4 2.00797199030434 0.0599571980489553 0.282012963680265 GO:0008173 RNA methyltransferase activity 19/3713 67/18639 0.283582089552239 1.42356223193218 0.0614877215759854 0.288182666603462 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 64/3713 268/18639 0.238805970149254 1.19878924794289 0.061934280148144 0.289246265798247 GO:0031490 chromatin DNA binding 33/3713 128/18639 0.2578125 1.29420069687584 0.0632232400040369 0.294222639877444 GO:0004518 nuclease activity 51/3713 209/18639 0.244019138755981 1.22495898930049 0.0638416731453125 0.296054519480199 GO:0017022 myosin binding 21/3713 76/18639 0.276315789473684 1.38708591435497 0.0654687125084358 0.301476553753881 GO:0051536 iron-sulfur cluster binding 21/3713 76/18639 0.276315789473684 1.38708591435497 0.0654687125084358 0.301476553753881 GO:0005346 purine ribonucleotide transmembrane transporter activity 7/3713 19/18639 0.368421052631579 1.84944788580663 0.0662763317826362 0.302027435839903 GO:0016918 retinal binding 7/3713 19/18639 0.368421052631579 1.84944788580663 0.0662763317826362 0.302027435839903 GO:1990380 K48-linked deubiquitinase activity 7/3713 19/18639 0.368421052631579 1.84944788580663 0.0662763317826362 0.302027435839903 GO:0000510 H3-H4 histone complex chaperone activity 38/3713 151/18639 0.251655629139073 1.26329363628418 0.0674254679109035 0.30306942402273 GO:0140584 chromatin extrusion motor activity 38/3713 151/18639 0.251655629139073 1.26329363628418 0.0674254679109035 0.30306942402273 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 38/3713 151/18639 0.251655629139073 1.26329363628418 0.0674254679109035 0.30306942402273 GO:0140849 ATP-dependent H2AZ histone chaperone activity 38/3713 151/18639 0.251655629139073 1.26329363628418 0.0674254679109035 0.30306942402273 GO:0061733 protein-lysine-acetyltransferase activity 14/3713 47/18639 0.297872340425532 1.49529829065217 0.0699108114517176 0.311406812433601 GO:0008171 O-methyltransferase activity 8/3713 23/18639 0.347826086956522 1.74606260026464 0.0699896860139299 0.311406812433601 GO:0031681 G-protein beta-subunit binding 8/3713 23/18639 0.347826086956522 1.74606260026464 0.0699896860139299 0.311406812433601 GO:0030971 receptor tyrosine kinase binding 22/3713 81/18639 0.271604938271605 1.3634377711943 0.0711277526601606 0.311549954072117 GO:0004300 enoyl-CoA hydratase activity 5/3713 12/18639 0.416666666666667 2.09163748990035 0.0714412195366585 0.311549954072117 GO:0005049 nuclear export signal receptor activity 5/3713 12/18639 0.416666666666667 2.09163748990035 0.0714412195366585 0.311549954072117 GO:0031543 peptidyl-proline dioxygenase activity 5/3713 12/18639 0.416666666666667 2.09163748990035 0.0714412195366585 0.311549954072117 GO:0035259 nuclear glucocorticoid receptor binding 5/3713 12/18639 0.416666666666667 2.09163748990035 0.0714412195366585 0.311549954072117 GO:0035497 cAMP response element binding 5/3713 12/18639 0.416666666666667 2.09163748990035 0.0714412195366585 0.311549954072117 GO:0005385 zinc ion transmembrane transporter activity 9/3713 27/18639 0.333333333333333 1.67330999192028 0.0719742773199021 0.311809615889181 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 9/3713 27/18639 0.333333333333333 1.67330999192028 0.0719742773199021 0.311809615889181 GO:0015616 DNA translocase activity 38/3713 152/18639 0.25 1.25498249394021 0.0732369118939148 0.31623938676815 GO:0051540 metal cluster binding 21/3713 77/18639 0.272727272727273 1.36907181157114 0.0737623543167193 0.317467387696468 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 17/3713 60/18639 0.283333333333333 1.42231349313224 0.0746036964442337 0.320042567482266 GO:0003697 single-stranded DNA binding 31/3713 121/18639 0.256198347107438 1.28609776238501 0.0750996113255752 0.321123987388904 GO:0008080 N-acetyltransferase activity 19/3713 69/18639 0.27536231884058 1.38229955854284 0.0792565779523131 0.337802307971509 GO:0004707 MAP kinase activity 6/3713 16/18639 0.375 1.88247374091032 0.080295257059986 0.33785576213419 GO:0019841 retinol binding 6/3713 16/18639 0.375 1.88247374091032 0.080295257059986 0.33785576213419 GO:0022858 alanine transmembrane transporter activity 6/3713 16/18639 0.375 1.88247374091032 0.080295257059986 0.33785576213419 GO:0034450 ubiquitin-ubiquitin ligase activity 6/3713 16/18639 0.375 1.88247374091032 0.080295257059986 0.33785576213419 GO:0032266 phosphatidylinositol-3-phosphate binding 14/3713 48/18639 0.291666666666667 1.46414624293024 0.0813258268766097 0.341102273874188 GO:0140658 ATP-dependent chromatin remodeler activity 39/3713 158/18639 0.246835443037975 1.23909663958654 0.0824593679804303 0.344758690889609 GO:0001046 core promoter sequence-specific DNA binding 13/3713 44/18639 0.295454545454545 1.48316112920207 0.0833618390196009 0.347428930344349 GO:0031418 L-ascorbic acid binding 7/3713 20/18639 0.35 1.75697549151629 0.0850725160582446 0.350595371044578 GO:0043024 ribosomal small subunit binding 7/3713 20/18639 0.35 1.75697549151629 0.0850725160582446 0.350595371044578 GO:0052745 inositol phosphate phosphatase activity 7/3713 20/18639 0.35 1.75697549151629 0.0850725160582446 0.350595371044578 GO:0032451 demethylase activity 12/3713 40/18639 0.3 1.50597899272825 0.0851864227291306 0.350595371044578 GO:0019838 growth factor binding 34/3713 136/18639 0.25 1.25498249394021 0.0862353443504262 0.353806693176048 GO:0016409 palmitoyltransferase activity 11/3713 36/18639 0.305555555555556 1.53386749259359 0.0866930563555865 0.354579985156234 GO:0048027 mRNA 5'-UTR binding 8/3713 24/18639 0.333333333333333 1.67330999192028 0.0873620866003672 0.35468816719678 GO:0051059 NF-kappaB binding 10/3713 32/18639 0.3125 1.56872811742526 0.0877283640033457 0.35468816719678 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 9/3713 28/18639 0.321428571428571 1.61354892078027 0.0880660825158292 0.35468816719678 GO:0097718 disordered domain specific binding 9/3713 28/18639 0.321428571428571 1.61354892078027 0.0880660825158292 0.35468816719678 GO:0141052 histone H3 demethylase activity 9/3713 28/18639 0.321428571428571 1.61354892078027 0.0880660825158292 0.35468816719678 GO:0140296 general transcription initiation factor binding 15/3713 53/18639 0.283018867924528 1.42073489880024 0.0909140032009573 0.365041896998966 GO:0000149 SNARE binding 27/3713 106/18639 0.254716981132075 1.27866140892021 0.0970534865371233 0.387525024806648 GO:0043560 insulin receptor substrate binding 5/3713 13/18639 0.384615384615385 1.93074229836955 0.0976904390552825 0.387525024806648 GO:0070123 transforming growth factor beta receptor activity, type III 5/3713 13/18639 0.384615384615385 1.93074229836955 0.0976904390552825 0.387525024806648 GO:0097157 pre-mRNA intronic binding 5/3713 13/18639 0.384615384615385 1.93074229836955 0.0976904390552825 0.387525024806648 GO:0016887 ATP hydrolysis activity 94/3713 417/18639 0.225419664268585 1.13159092978782 0.0991838199599649 0.392267540202023 GO:0008429 phosphatidylethanolamine binding 6/3713 17/18639 0.352941176470588 1.771739991445 0.103989319687024 0.407600994130388 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/3713 17/18639 0.352941176470588 1.771739991445 0.103989319687024 0.407600994130388 GO:1990226 histone methyltransferase binding 6/3713 17/18639 0.352941176470588 1.771739991445 0.103989319687024 0.407600994130388 GO:0140311 protein sequestering activity 10/3713 33/18639 0.303030303030303 1.52119090174571 0.104385234198915 0.407938734243237 GO:0016417 S-acyltransferase activity 9/3713 29/18639 0.310344827586207 1.55790930282233 0.10611093534899 0.412068488579369 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 7/3713 21/18639 0.333333333333333 1.67330999192028 0.106579540073816 0.412068488579369 GO:0000030 mannosyltransferase activity 8/3713 25/18639 0.32 1.60637759224347 0.107006395667535 0.412068488579369 GO:0003707 nuclear steroid receptor activity 8/3713 25/18639 0.32 1.60637759224347 0.107006395667535 0.412068488579369 GO:0019211 phosphatase activator activity 8/3713 25/18639 0.32 1.60637759224347 0.107006395667535 0.412068488579369 GO:1901981 phosphatidylinositol phosphate binding 44/3713 185/18639 0.237837837837838 1.19392929153231 0.110914961704861 0.425874648878432 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 40/3713 167/18639 0.239520958083832 1.20237843730799 0.114038336188364 0.436594444069985 GO:0019894 kinesin binding 12/3713 42/18639 0.285714285714286 1.43426570736024 0.11527323592549 0.44002229816012 GO:1990782 protein tyrosine kinase binding 29/3713 117/18639 0.247863247863248 1.24425614783816 0.115601909767199 0.44002229816012 GO:0005543 phospholipid binding 110/3713 497/18639 0.221327967806841 1.11105090006779 0.116929326237354 0.44304084040795 GO:0004713 protein tyrosine kinase activity 34/3713 140/18639 0.242857142857143 1.2191258512562 0.118100822446107 0.44304084040795 GO:0016427 tRNA (cytidine) methyltransferase activity 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0030957 Tat protein binding 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0031434 mitogen-activated protein kinase kinase binding 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0032356 oxidized DNA binding 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0043422 protein kinase B binding 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0045322 unmethylated CpG binding 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0099122 RNA polymerase II C-terminal domain binding 4/3713 10/18639 0.4 2.00797199030434 0.119422549996069 0.44304084040795 GO:0052866 phosphatidylinositol phosphate phosphatase activity 10/3713 34/18639 0.294117647058824 1.47644999287084 0.122730194841787 0.454032771366948 GO:0015215 nucleotide transmembrane transporter activity 9/3713 30/18639 0.3 1.50597899272825 0.126070303618998 0.461162925872957 GO:0032452 histone demethylase activity 9/3713 30/18639 0.3 1.50597899272825 0.126070303618998 0.461162925872957 GO:0048019 receptor antagonist activity 9/3713 30/18639 0.3 1.50597899272825 0.126070303618998 0.461162925872957 GO:0001784 phosphotyrosine residue binding 13/3713 47/18639 0.276595744680851 1.3884912698913 0.127269721392149 0.461162925872957 GO:0140359 ABC-type transporter activity 13/3713 47/18639 0.276595744680851 1.3884912698913 0.127269721392149 0.461162925872957 GO:0004705 JUN kinase activity 5/3713 14/18639 0.357142857142857 1.7928321342003 0.128057883237995 0.461162925872957 GO:0005161 platelet-derived growth factor receptor binding 5/3713 14/18639 0.357142857142857 1.7928321342003 0.128057883237995 0.461162925872957 GO:0008191 metalloendopeptidase inhibitor activity 5/3713 14/18639 0.357142857142857 1.7928321342003 0.128057883237995 0.461162925872957 GO:0071933 Arp2/3 complex binding 5/3713 14/18639 0.357142857142857 1.7928321342003 0.128057883237995 0.461162925872957 GO:0008157 protein phosphatase 1 binding 8/3713 26/18639 0.307692307692308 1.54459383869564 0.128859496371487 0.461162925872957 GO:0050681 nuclear androgen receptor binding 8/3713 26/18639 0.307692307692308 1.54459383869564 0.128859496371487 0.461162925872957 GO:0050750 low-density lipoprotein particle receptor binding 8/3713 26/18639 0.307692307692308 1.54459383869564 0.128859496371487 0.461162925872957 GO:0046972 histone H4K16 acetyltransferase activity 7/3713 22/18639 0.318181818181818 1.59725044683299 0.130695870451315 0.464584900722789 GO:0050321 tau-protein kinase activity 7/3713 22/18639 0.318181818181818 1.59725044683299 0.130695870451315 0.464584900722789 GO:0070064 proline-rich region binding 6/3713 18/18639 0.333333333333333 1.67330999192028 0.130873954569593 0.464584900722789 GO:0048156 tau protein binding 12/3713 43/18639 0.27906976744186 1.40091069091 0.132336569144629 0.467795075172401 GO:0003689 DNA clamp loader activity 38/3713 160/18639 0.2375 1.1922333692432 0.132488658344196 0.467795075172401 GO:0000217 DNA secondary structure binding 11/3713 39/18639 0.282051282051282 1.41587768547101 0.137503745645255 0.484204366349735 GO:0008013 beta-catenin binding 26/3713 106/18639 0.245283018867925 1.23130357896021 0.14299158679835 0.502186452835804 GO:0140457 protein demethylase activity 9/3713 31/18639 0.290322580645161 1.45739902522089 0.147870193999346 0.517938950790264 GO:0030547 signaling receptor inhibitor activity 12/3713 44/18639 0.272727272727273 1.36907181157114 0.150702092941514 0.525065228581942 GO:0043014 alpha-tubulin binding 12/3713 44/18639 0.272727272727273 1.36907181157114 0.150702092941514 0.525065228581942 GO:0001671 ATPase activator activity 8/3713 27/18639 0.296296296296296 1.48738665948469 0.152811167551101 0.529611335960001 GO:0004683 calcium/calmodulin-dependent protein kinase activity 8/3713 27/18639 0.296296296296296 1.48738665948469 0.152811167551101 0.529611335960001 GO:0000295 adenine nucleotide transmembrane transporter activity 7/3713 23/18639 0.304347826086957 1.52780477523156 0.157254826142672 0.532410307784094 GO:0005212 structural constituent of eye lens 7/3713 23/18639 0.304347826086957 1.52780477523156 0.157254826142672 0.532410307784094 GO:0017134 fibroblast growth factor binding 7/3713 23/18639 0.304347826086957 1.52780477523156 0.157254826142672 0.532410307784094 GO:0044013 histone H2B acetyltransferase activity 7/3713 23/18639 0.304347826086957 1.52780477523156 0.157254826142672 0.532410307784094 GO:0002162 dystroglycan binding 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0003953 NAD+ nucleosidase activity 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0005225 volume-sensitive anion channel activity 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0008432 JUN kinase binding 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0019206 nucleoside kinase activity 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0048185 activin binding 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0050998 nitric-oxide synthase binding 4/3713 11/18639 0.363636363636364 1.82542908209485 0.159325503166281 0.532410307784094 GO:0042577 lipid phosphatase activity 6/3713 19/18639 0.315789473684211 1.58524104497711 0.160688242009728 0.532410307784094 GO:0050145 nucleoside monophosphate kinase activity 6/3713 19/18639 0.315789473684211 1.58524104497711 0.160688242009728 0.532410307784094 GO:0120227 acyl-CoA binding 6/3713 19/18639 0.315789473684211 1.58524104497711 0.160688242009728 0.532410307784094 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0031005 filamin binding 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0031386 protein tag activity 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0042809 nuclear vitamin D receptor binding 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0050780 dopamine receptor binding 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0051371 muscle alpha-actinin binding 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0141047 molecular tag activity 5/3713 15/18639 0.333333333333333 1.67330999192028 0.162108225832514 0.532410307784094 GO:0016410 N-acyltransferase activity 23/3713 94/18639 0.24468085106383 1.22828073874999 0.163724681664972 0.53638160635017 GO:0051539 4 iron, 4 sulfur cluster binding 12/3713 45/18639 0.266666666666667 1.33864799353622 0.170315688813581 0.556589980564482 GO:0140142 nucleocytoplasmic carrier activity 9/3713 32/18639 0.28125 1.41185530568274 0.171403953562999 0.558759917926904 GO:0004386 helicase activity 36/3713 155/18639 0.232258064516129 1.16591922017671 0.174490455723107 0.567417111573659 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 11/3713 41/18639 0.268292682926829 1.34681048130169 0.178541038684399 0.579158985092002 GO:0070888 E-box binding 15/3713 59/18639 0.254237288135593 1.27625338366801 0.183001355375021 0.59216900498502 GO:0043998 histone H2A acetyltransferase activity 7/3713 24/18639 0.291666666666667 1.46414624293024 0.18603418948362 0.599039187163638 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 7/3713 24/18639 0.291666666666667 1.46414624293024 0.18603418948362 0.599039187163638 GO:0140313 molecular sequestering activity 14/3713 55/18639 0.254545454545455 1.2778003574664 0.192295319131027 0.615410318253103 GO:0000339 RNA cap binding 6/3713 20/18639 0.3 1.50597899272825 0.193094981703221 0.615410318253103 GO:0015095 magnesium ion transmembrane transporter activity 6/3713 20/18639 0.3 1.50597899272825 0.193094981703221 0.615410318253103 GO:0016505 peptidase activator activity involved in apoptotic process 6/3713 20/18639 0.3 1.50597899272825 0.193094981703221 0.615410318253103 GO:0000062 fatty-acyl-CoA binding 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0004708 MAP kinase kinase activity 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0005024 transforming growth factor beta receptor activity 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0005159 insulin-like growth factor receptor binding 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0008142 oxysterol binding 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0016722 oxidoreductase activity, acting on metal ions 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0030275 LRR domain binding 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0043023 ribosomal large subunit binding 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0140328 floppase activity 5/3713 16/18639 0.3125 1.56872811742526 0.199295938910936 0.615410318253103 GO:0002039 p53 binding 17/3713 69/18639 0.246376811594203 1.23679434185412 0.200026501405081 0.615410318253103 GO:0016829 lyase activity 45/3713 200/18639 0.225 1.12948424454619 0.201907817313876 0.615410318253103 GO:0005010 insulin-like growth factor receptor activity 13/3713 51/18639 0.254901960784314 1.27958999382139 0.202264855203995 0.615410318253103 GO:0016830 carbon-carbon lyase activity 13/3713 51/18639 0.254901960784314 1.27958999382139 0.202264855203995 0.615410318253103 GO:0005025 transforming growth factor beta receptor activity, type I 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0005026 transforming growth factor beta receptor activity, type II 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0005247 voltage-gated chloride channel activity 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0016361 activin receptor activity, type I 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0016362 activin receptor activity, type II 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0017002 activin receptor activity 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 4/3713 12/18639 0.333333333333333 1.67330999192028 0.203267644981093 0.615410318253103 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 8/3713 29/18639 0.275862068965517 1.3848082691754 0.206365683933294 0.621930447917959 GO:0106222 lncRNA binding 8/3713 29/18639 0.275862068965517 1.3848082691754 0.206365683933294 0.621930447917959 GO:0042162 telomeric DNA binding 10/3713 38/18639 0.263157894736842 1.32103420414759 0.211623304067318 0.634869912201955 GO:0043531 ADP binding 10/3713 38/18639 0.263157894736842 1.32103420414759 0.211623304067318 0.634869912201955 GO:0043495 protein-membrane adaptor activity 12/3713 47/18639 0.25531914893617 1.28168424913043 0.212995243674371 0.637533490725333 GO:0004709 MAP kinase kinase kinase activity 7/3713 25/18639 0.28 1.40558039321304 0.216767220412098 0.644429862940706 GO:0019706 protein-cysteine S-palmitoyltransferase activity 7/3713 25/18639 0.28 1.40558039321304 0.216767220412098 0.644429862940706 GO:0019707 protein-cysteine S-acyltransferase activity 7/3713 25/18639 0.28 1.40558039321304 0.216767220412098 0.644429862940706 GO:0016836 hydro-lyase activity 15/3713 61/18639 0.245901639344262 1.23440901043299 0.221245520015849 0.654787303058143 GO:0019905 syntaxin binding 15/3713 61/18639 0.245901639344262 1.23440901043299 0.221245520015849 0.654787303058143 GO:0042626 ATPase-coupled transmembrane transporter activity 23/3713 98/18639 0.23469387755102 1.17814683104591 0.22184119816591 0.655078156915927 GO:0009975 cyclase activity 6/3713 21/18639 0.285714285714286 1.43426570736024 0.227701158354982 0.669380414181946 GO:0140312 cargo adaptor activity 6/3713 21/18639 0.285714285714286 1.43426570736024 0.227701158354982 0.669380414181946 GO:0001968 fibronectin binding 8/3713 30/18639 0.266666666666667 1.33864799353622 0.235564004047583 0.688779559835505 GO:0033612 receptor serine/threonine kinase binding 8/3713 30/18639 0.266666666666667 1.33864799353622 0.235564004047583 0.688779559835505 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:0004659 prenyltransferase activity 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:0032977 membrane insertase activity 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:0046965 nuclear retinoid X receptor binding 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:0051787 misfolded protein binding 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:1901567 fatty acid derivative binding 5/3713 17/18639 0.294117647058824 1.47644999287084 0.239007030254234 0.688779559835505 GO:0098631 cell adhesion mediator activity 18/3713 76/18639 0.236842105263158 1.18893078373283 0.243659586620283 0.700654313491077 GO:0008168 methyltransferase activity 45/3713 204/18639 0.220588235294118 1.10733749465313 0.245116641068692 0.700754489452068 GO:0005246 calcium channel regulator activity 13/3713 53/18639 0.245283018867925 1.23130357896021 0.245822759397764 0.700754489452068 GO:0038064 collagen receptor activity 13/3713 53/18639 0.245283018867925 1.23130357896021 0.245822759397764 0.700754489452068 GO:1901505 carbohydrate derivative transmembrane transporter activity 13/3713 53/18639 0.245283018867925 1.23130357896021 0.245822759397764 0.700754489452068 GO:0015216 purine nucleotide transmembrane transporter activity 7/3713 26/18639 0.269230769230769 1.35151960885869 0.249154276637586 0.704030186471529 GO:0043548 phosphatidylinositol 3-kinase binding 7/3713 26/18639 0.269230769230769 1.35151960885869 0.249154276637586 0.704030186471529 GO:0019205 nucleobase-containing compound kinase activity 11/3713 44/18639 0.25 1.25498249394021 0.249220411483136 0.704030186471529 GO:0050840 extracellular matrix binding 16/3713 67/18639 0.238805970149254 1.19878924794289 0.24924233967733 0.704030186471529 GO:0005172 vascular endothelial growth factor receptor binding 4/3713 13/18639 0.307692307692308 1.54459383869564 0.250190847614787 0.704030186471529 GO:0005004 GPI-linked ephrin receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0005008 hepatocyte growth factor receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0005009 insulin receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0005011 macrophage colony-stimulating factor receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0005018 platelet-derived growth factor alpha-receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0005020 stem cell factor receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0008288 boss receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0036332 placental growth factor receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0038062 protein tyrosine kinase collagen receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0060175 brain-derived neurotrophic factor receptor activity 12/3713 49/18639 0.244897959183673 1.22937060630878 0.25966246817236 0.704030186471529 GO:0061791 GTPase motor activity 10/3713 40/18639 0.25 1.25498249394021 0.263792947504617 0.704030186471529 GO:1990606 membrane scission GTPase motor activity 10/3713 40/18639 0.25 1.25498249394021 0.263792947504617 0.704030186471529 GO:0008649 rRNA methyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0032931 histone H3K56 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0043992 histone H3K9 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0043993 histone H3K18 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0043994 histone H3K23 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0043999 histone H2AK5 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0044012 histone H2AK9 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0044014 histone H2BK5 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0044015 histone H2BK12 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0044016 histone H3K4 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0044017 histone H3K27 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0044018 histone H3K36 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0070034 telomerase RNA binding 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0140908 histone H3K122 acetyltransferase activity 6/3713 22/18639 0.272727272727273 1.36907181157114 0.264078141318857 0.704030186471529 GO:0017147 Wnt-protein binding 8/3713 31/18639 0.258064516129032 1.29546580019635 0.26606619884697 0.706470128793265 GO:0070325 lipoprotein particle receptor binding 8/3713 31/18639 0.258064516129032 1.29546580019635 0.26606619884697 0.706470128793265 GO:0004715 non-membrane spanning protein tyrosine kinase activity 11/3713 45/18639 0.244444444444444 1.22709399407487 0.274748409993874 0.726593686670546 GO:0140303 intramembrane lipid transporter activity 11/3713 45/18639 0.244444444444444 1.22709399407487 0.274748409993874 0.726593686670546 GO:0001786 phosphatidylserine binding 14/3713 59/18639 0.23728813559322 1.19116982475681 0.276950110676166 0.730327708781709 GO:0005484 SNAP receptor activity 9/3713 36/18639 0.25 1.25498249394021 0.279825580436338 0.730327708781709 GO:0000400 four-way junction DNA binding 5/3713 18/18639 0.277777777777778 1.3944249932669 0.280596674748326 0.730327708781709 GO:0000900 mRNA regulatory element binding translation repressor activity 5/3713 18/18639 0.277777777777778 1.3944249932669 0.280596674748326 0.730327708781709 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 5/3713 18/18639 0.277777777777778 1.3944249932669 0.280596674748326 0.730327708781709 GO:0017075 syntaxin-1 binding 5/3713 18/18639 0.277777777777778 1.3944249932669 0.280596674748326 0.730327708781709 GO:0017128 phospholipid scramblase activity 5/3713 18/18639 0.277777777777778 1.3944249932669 0.280596674748326 0.730327708781709 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 5/3713 18/18639 0.277777777777778 1.3944249932669 0.280596674748326 0.730327708781709 GO:0019199 transmembrane receptor protein kinase activity 18/3713 78/18639 0.230769230769231 1.15844537902173 0.282122413004802 0.732524703734191 GO:0005006 epidermal growth factor receptor activity 12/3713 50/18639 0.24 1.2047831941826 0.284221809877123 0.732524703734191 GO:0005007 fibroblast growth factor receptor activity 12/3713 50/18639 0.24 1.2047831941826 0.284221809877123 0.732524703734191 GO:0005017 platelet-derived growth factor receptor activity 12/3713 50/18639 0.24 1.2047831941826 0.284221809877123 0.732524703734191 GO:0005019 platelet-derived growth factor beta-receptor activity 12/3713 50/18639 0.24 1.2047831941826 0.284221809877123 0.732524703734191 GO:0004197 cysteine-type endopeptidase activity 20/3713 88/18639 0.227272727272727 1.14089317630928 0.292562396940703 0.752548196818175 GO:0005347 ATP transmembrane transporter activity 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0005545 1-phosphatidylinositol binding 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0019992 diacylglycerol binding 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0030983 mismatched DNA binding 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0032454 histone H3K9 demethylase activity 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0046030 inositol trisphosphate phosphatase activity 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0061665 SUMO ligase activity 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0070742 C2H2 zinc finger domain binding 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0098821 BMP receptor activity 4/3713 14/18639 0.285714285714286 1.43426570736024 0.299044033365503 0.754484658893425 GO:0008170 N-methyltransferase activity 22/3713 98/18639 0.224489795918367 1.12692305578305 0.301496443908675 0.755598673955503 GO:0003887 DNA-directed DNA polymerase activity 6/3713 23/18639 0.260869565217391 1.30954695019848 0.301780487851628 0.755598673955503 GO:0005158 insulin receptor binding 6/3713 23/18639 0.260869565217391 1.30954695019848 0.301780487851628 0.755598673955503 GO:0140102 catalytic activity, acting on a rRNA 6/3713 23/18639 0.260869565217391 1.30954695019848 0.301780487851628 0.755598673955503 GO:0019843 rRNA binding 15/3713 65/18639 0.230769230769231 1.15844537902173 0.306397100231935 0.765702051243754 GO:0005021 vascular endothelial growth factor receptor activity 12/3713 51/18639 0.235294117647059 1.18115999429667 0.309439334391932 0.766374138823884 GO:0005030 neurotrophin receptor activity 12/3713 51/18639 0.235294117647059 1.18115999429667 0.309439334391932 0.766374138823884 GO:0005048 signal sequence binding 12/3713 51/18639 0.235294117647059 1.18115999429667 0.309439334391932 0.766374138823884 GO:0030544 Hsp70 protein binding 12/3713 51/18639 0.235294117647059 1.18115999429667 0.309439334391932 0.766374138823884 GO:0042805 actinin binding 9/3713 37/18639 0.243243243243243 1.22106404815804 0.309575582273581 0.766374138823884 GO:0015399 primary active transmembrane transporter activity 36/3713 166/18639 0.216867469879518 1.0886595128156 0.312280766049976 0.771620579526863 GO:0051393 alpha-actinin binding 7/3713 28/18639 0.25 1.25498249394021 0.317596085902071 0.774190222073634 GO:0016741 transferase activity, transferring one-carbon groups 46/3713 215/18639 0.213953488372093 1.07403152969767 0.318526547156541 0.774190222073634 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0004955 prostaglandin receptor activity 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0005381 iron ion transmembrane transporter activity 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0005528 FK506 binding 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0016783 sulfurtransferase activity 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0050815 phosphoserine residue binding 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0051864 histone H3K36 demethylase activity 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0051880 G-quadruplex DNA binding 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:1990763 arrestin family protein binding 3/3713 10/18639 0.3 1.50597899272825 0.31978700137286 0.774190222073634 GO:0140036 ubiquitin-modified protein reader activity 5/3713 19/18639 0.263157894736842 1.32103420414759 0.323421115012111 0.781551575176055 GO:0140299 molecular sensor activity 16/3713 71/18639 0.225352112676056 1.13125182552357 0.334230298600803 0.806192863108529 GO:0005080 protein kinase C binding 12/3713 52/18639 0.230769230769231 1.15844537902173 0.33518992302445 0.807029485600002 GO:0050699 WW domain binding 6/3713 24/18639 0.25 1.25498249394021 0.340362587307631 0.81649822856858 GO:0060229 lipase activator activity 6/3713 24/18639 0.25 1.25498249394021 0.340362587307631 0.81649822856858 GO:0140101 catalytic activity, acting on a tRNA 30/3713 139/18639 0.215827338129496 1.08343812426493 0.343246887271667 0.821920273703246 GO:0004953 icosanoid receptor activity 4/3713 15/18639 0.266666666666667 1.33864799353622 0.348838872468408 0.832284048987126 GO:0050700 CARD domain binding 4/3713 15/18639 0.266666666666667 1.33864799353622 0.348838872468408 0.832284048987126 GO:0015631 tubulin binding 80/3713 385/18639 0.207792207792208 1.04310233262563 0.354775501036495 0.844917422902467 GO:0005003 ephrin receptor activity 12/3713 53/18639 0.226415094339623 1.13658791904019 0.361346166037139 0.857464685893535 GO:0005005 transmembrane-ephrin receptor activity 12/3713 53/18639 0.226415094339623 1.13658791904019 0.361346166037139 0.857464685893535 GO:0008175 tRNA methyltransferase activity 8/3713 34/18639 0.235294117647059 1.18115999429667 0.362847629819338 0.857935957759548 GO:0016831 carboxy-lyase activity 8/3713 34/18639 0.235294117647059 1.18115999429667 0.362847629819338 0.857935957759548 GO:0016004 phospholipase activator activity 5/3713 20/18639 0.25 1.25498249394021 0.366863159448407 0.865875951601348 GO:0008139 nuclear localization sequence binding 6/3713 25/18639 0.24 1.2047831941826 0.379392703169379 0.876370233335956 GO:0015662 P-type ion transporter activity 6/3713 25/18639 0.24 1.2047831941826 0.379392703169379 0.876370233335956 GO:0042974 nuclear retinoic acid receptor binding 6/3713 25/18639 0.24 1.2047831941826 0.379392703169379 0.876370233335956 GO:0140358 P-type transmembrane transporter activity 6/3713 25/18639 0.24 1.2047831941826 0.379392703169379 0.876370233335956 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0004016 adenylate cyclase activity 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0004954 prostanoid receptor activity 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0015217 ADP transmembrane transporter activity 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0019107 myristoyltransferase activity 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0032050 clathrin heavy chain binding 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0048407 platelet-derived growth factor binding 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0140031 phosphorylation-dependent protein binding 3/3713 11/18639 0.272727272727273 1.36907181157114 0.379960063200327 0.876370233335956 GO:0004519 endonuclease activity 27/3713 127/18639 0.21259842519685 1.06722920744522 0.386664542322327 0.889732815430524 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 12/3713 54/18639 0.222222222222222 1.11553999461352 0.387780285540714 0.889732815430524 GO:0051287 NAD binding 12/3713 54/18639 0.222222222222222 1.11553999461352 0.387780285540714 0.889732815430524 GO:0031210 phosphatidylcholine binding 7/3713 30/18639 0.233333333333333 1.1713169943442 0.388725186730203 0.890349688562917 GO:0051213 dioxygenase activity 20/3713 93/18639 0.21505376344086 1.07955483349695 0.390706131150462 0.8933332894534 GO:0005126 cytokine receptor binding 57/3713 275/18639 0.207272727272727 1.04049457679407 0.391626803085534 0.893886481219495 GO:0043015 gamma-tubulin binding 8/3713 35/18639 0.228571428571429 1.14741256588819 0.396007166558624 0.902320827608492 GO:0003688 DNA replication origin binding 4/3713 16/18639 0.25 1.25498249394021 0.398686516987566 0.903735185667168 GO:0005149 interleukin-1 receptor binding 4/3713 16/18639 0.25 1.25498249394021 0.398686516987566 0.903735185667168 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/3713 16/18639 0.25 1.25498249394021 0.398686516987566 0.903735185667168 GO:0003684 damaged DNA binding 16/3713 74/18639 0.216216216216216 1.08539026502937 0.401784176236045 0.906300242023214 GO:0031491 nucleosome binding 16/3713 74/18639 0.216216216216216 1.08539026502937 0.401784176236045 0.906300242023214 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 9/3713 40/18639 0.225 1.12948424454619 0.401882567457522 0.906300242023214 GO:0016835 carbon-oxygen lyase activity 17/3713 79/18639 0.215189873417722 1.0802380960498 0.40440974562185 0.910440401682011 GO:0036122 BMP binding 5/3713 21/18639 0.238095238095238 1.1952214228002 0.410351284790102 0.917542686024728 GO:0051010 microtubule plus-end binding 5/3713 21/18639 0.238095238095238 1.1952214228002 0.410351284790102 0.917542686024728 GO:0072542 protein phosphatase activator activity 5/3713 21/18639 0.238095238095238 1.1952214228002 0.410351284790102 0.917542686024728 GO:1904047 S-adenosyl-L-methionine binding 5/3713 21/18639 0.238095238095238 1.1952214228002 0.410351284790102 0.917542686024728 GO:0098632 cell-cell adhesion mediator activity 12/3713 55/18639 0.218181818181818 1.09525744925691 0.414365933473 0.924949041328714 GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/3713 60/18639 0.216666666666667 1.08765149474818 0.417422301163349 0.927807057907041 GO:0004112 cyclic-nucleotide phosphodiesterase activity 6/3713 26/18639 0.230769230769231 1.15844537902173 0.418464231128916 0.927807057907041 GO:0008198 ferrous iron binding 6/3713 26/18639 0.230769230769231 1.15844537902173 0.418464231128916 0.927807057907041 GO:0034237 protein kinase A regulatory subunit binding 6/3713 26/18639 0.230769230769231 1.15844537902173 0.418464231128916 0.927807057907041 GO:0097110 scaffold protein binding 15/3713 70/18639 0.214285714285714 1.07569928052018 0.422485224456962 0.935147967411461 GO:0008327 methyl-CpG binding 7/3713 31/18639 0.225806451612903 1.1335325751718 0.424500724862813 0.938032642020678 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/3713 36/18639 0.222222222222222 1.11553999461352 0.429201905450706 0.943670967409984 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/3713 36/18639 0.222222222222222 1.11553999461352 0.429201905450706 0.943670967409984 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/3713 36/18639 0.222222222222222 1.11553999461352 0.429201905450706 0.943670967409984 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/3713 41/18639 0.219512195121951 1.10193584833775 0.432985724890024 0.944404207243587 GO:0016877 ligase activity, forming carbon-sulfur bonds 9/3713 41/18639 0.219512195121951 1.10193584833775 0.432985724890024 0.944404207243587 GO:0140318 protein transporter activity 9/3713 41/18639 0.219512195121951 1.10193584833775 0.432985724890024 0.944404207243587 GO:0017124 SH3 domain binding 24/3713 115/18639 0.208695652173913 1.04763756015878 0.435966815282192 0.944404207243587 GO:0000340 RNA 7-methylguanosine cap binding 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0004859 phospholipase inhibitor activity 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0005078 MAP-kinase scaffold activity 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0005095 GTPase inhibitor activity 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0005527 macrolide binding 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0043047 single-stranded telomeric DNA binding 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/3713 12/18639 0.25 1.25498249394021 0.438857535940072 0.944404207243587 GO:0004549 tRNA-specific ribonuclease activity 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0005092 GDP-dissociation inhibitor activity 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0008484 sulfuric ester hydrolase activity 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0031489 myosin V binding 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0048038 quinone binding 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0070403 NAD+ binding 4/3713 17/18639 0.235294117647059 1.18115999429667 0.447818666751668 0.952790281279398 GO:0008093 cytoskeletal anchor activity 5/3713 22/18639 0.227272727272727 1.14089317630928 0.453372797575763 0.958414084120835 GO:0034062 5'-3' RNA polymerase activity 5/3713 22/18639 0.227272727272727 1.14089317630928 0.453372797575763 0.958414084120835 GO:0097747 RNA polymerase activity 5/3713 22/18639 0.227272727272727 1.14089317630928 0.453372797575763 0.958414084120835 GO:0140035 ubiquitin-like protein reader activity 5/3713 22/18639 0.227272727272727 1.14089317630928 0.453372797575763 0.958414084120835 GO:0044325 transmembrane transporter binding 28/3713 136/18639 0.205882352941176 1.03351499500958 0.456578709936476 0.960347563144409 GO:0005104 fibroblast growth factor receptor binding 6/3713 27/18639 0.222222222222222 1.11553999461352 0.457204192932076 0.960347563144409 GO:0008320 protein transmembrane transporter activity 6/3713 27/18639 0.222222222222222 1.11553999461352 0.457204192932076 0.960347563144409 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/3713 27/18639 0.222222222222222 1.11553999461352 0.457204192932076 0.960347563144409 GO:0022884 macromolecule transmembrane transporter activity 7/3713 32/18639 0.21875 1.09810968219768 0.460027249254078 0.963204908215613 GO:0031369 translation initiation factor binding 7/3713 32/18639 0.21875 1.09810968219768 0.460027249254078 0.963204908215613 GO:0004520 DNA endonuclease activity 9/3713 42/18639 0.214285714285714 1.07569928052018 0.463932792347239 0.966771341014736 GO:0016859 cis-trans isomerase activity 9/3713 42/18639 0.214285714285714 1.07569928052018 0.463932792347239 0.966771341014736 GO:0048487 beta-tubulin binding 9/3713 42/18639 0.214285714285714 1.07569928052018 0.463932792347239 0.966771341014736 GO:0015179 L-amino acid transmembrane transporter activity 13/3713 62/18639 0.209677419354839 1.05256596265953 0.468346703218099 0.974401344676736 GO:0016500 protein-hormone receptor activity 14/3713 67/18639 0.208955223880597 1.04894059195003 0.469073995842863 0.974401344676736 GO:0043178 alcohol binding 19/3713 92/18639 0.206521739130435 1.03672466890713 0.471565069521323 0.978033380408791 GO:0008083 growth factor activity 33/3713 162/18639 0.203703703703704 1.02257832839573 0.474229332854031 0.980640878172421 GO:0016874 ligase activity 34/3713 167/18639 0.203592814371257 1.02202167171179 0.474311495365096 0.980640878172421 GO:0004521 RNA endonuclease activity 15/3713 73/18639 0.205479452054795 1.03149246077278 0.493149596214751 0.984465204852496 GO:0005548 phospholipid transporter activity 14/3713 68/18639 0.205882352941176 1.03351499500958 0.493368426370121 0.984465204852496 GO:0016251 RNA polymerase II general transcription initiation factor activity 11/3713 53/18639 0.207547169811321 1.04187225912017 0.494059441319001 0.984465204852496 GO:0051018 protein kinase A binding 11/3713 53/18639 0.207547169811321 1.04187225912017 0.494059441319001 0.984465204852496 GO:0005501 retinoid binding 8/3713 38/18639 0.210526315789474 1.05682736331807 0.494796325211728 0.984465204852496 GO:0019840 isoprenoid binding 8/3713 38/18639 0.210526315789474 1.05682736331807 0.494796325211728 0.984465204852496 GO:0017154 semaphorin receptor activity 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0019855 calcium channel inhibitor activity 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0045159 myosin II binding 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0046974 histone H3K9 methyltransferase activity 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0061459 L-arginine transmembrane transporter activity 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0071837 HMG box domain binding 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0140333 glycerophospholipid flippase activity 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0140666 annealing activity 3/3713 13/18639 0.230769230769231 1.15844537902173 0.495457542437658 0.984465204852496 GO:0005283 amino acid:sodium symporter activity 5/3713 23/18639 0.217391304347826 1.0912891251654 0.495481772499133 0.984465204852496 GO:0016849 phosphorus-oxygen lyase activity 5/3713 23/18639 0.217391304347826 1.0912891251654 0.495481772499133 0.984465204852496 GO:0042171 lysophosphatidic acid acyltransferase activity 5/3713 23/18639 0.217391304347826 1.0912891251654 0.495481772499133 0.984465204852496 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/3713 23/18639 0.217391304347826 1.0912891251654 0.495481772499133 0.984465204852496 GO:0070577 lysine-acetylated histone binding 5/3713 23/18639 0.217391304347826 1.0912891251654 0.495481772499133 0.984465204852496 GO:0071617 lysophospholipid acyltransferase activity 5/3713 23/18639 0.217391304347826 1.0912891251654 0.495481772499133 0.984465204852496 GO:0003746 translation elongation factor activity 4/3713 18/18639 0.222222222222222 1.11553999461352 0.495596378752623 0.984465204852496 GO:0004706 JUN kinase kinase kinase activity 4/3713 18/18639 0.222222222222222 1.11553999461352 0.495596378752623 0.984465204852496 GO:0008409 5'-3' exonuclease activity 4/3713 18/18639 0.222222222222222 1.11553999461352 0.495596378752623 0.984465204852496 GO:0008525 phosphatidylcholine transporter activity 4/3713 18/18639 0.222222222222222 1.11553999461352 0.495596378752623 0.984465204852496 GO:0015172 acidic amino acid transmembrane transporter activity 4/3713 18/18639 0.222222222222222 1.11553999461352 0.495596378752623 0.984465204852496 GO:0035615 clathrin adaptor activity 4/3713 18/18639 0.222222222222222 1.11553999461352 0.495596378752623 0.984465204852496 GO:0019955 cytokine binding 29/3713 144/18639 0.201388888888889 1.0109581201185 0.507219989896768 1 GO:0008094 ATP-dependent activity, acting on DNA 42/3713 210/18639 0.2 1.00398599515217 0.516285787609484 1 GO:0140097 catalytic activity, acting on DNA 67/3713 336/18639 0.199404761904762 1.00099794159517 0.518497531362679 1 GO:0036002 pre-mRNA binding 12/3713 59/18639 0.203389830508475 1.02100270693441 0.519833865928034 1 GO:0019842 vitamin binding 30/3713 150/18639 0.2 1.00398599515217 0.523078779180798 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 9/3713 44/18639 0.204545454545455 1.02680385867835 0.524667995772699 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/3713 39/18639 0.205128205128205 1.0297292257971 0.526792176113304 1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 8/3713 39/18639 0.205128205128205 1.0297292257971 0.526792176113304 1 GO:0005416 amino acid:monoatomic cation symporter activity 6/3713 29/18639 0.206896551724138 1.03860620188155 0.532398666980482 1 GO:0008276 protein methyltransferase activity 19/3713 95/18639 0.2 1.00398599515217 0.533361939978125 1 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/3713 24/18639 0.208333333333333 1.04581874495018 0.536302610707423 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/3713 24/18639 0.208333333333333 1.04581874495018 0.536302610707423 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/3713 24/18639 0.208333333333333 1.04581874495018 0.536302610707423 1 GO:0004622 lysophospholipase activity 5/3713 24/18639 0.208333333333333 1.04581874495018 0.536302610707423 1 GO:0140033 acetylation-dependent protein binding 5/3713 24/18639 0.208333333333333 1.04581874495018 0.536302610707423 1 GO:0140612 DNA damage sensor activity 5/3713 24/18639 0.208333333333333 1.04581874495018 0.536302610707423 1 GO:0016757 glycosyltransferase activity 53/3713 267/18639 0.198501872659176 0.996465500806459 0.536341948429554 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/3713 19/18639 0.210526315789474 1.05682736331807 0.54150978241676 1 GO:0042800 histone H3K4 methyltransferase activity 4/3713 19/18639 0.210526315789474 1.05682736331807 0.54150978241676 1 GO:0097001 ceramide binding 4/3713 19/18639 0.210526315789474 1.05682736331807 0.54150978241676 1 GO:0046982 protein heterodimerization activity 73/3713 369/18639 0.197831978319783 0.993102678131548 0.547774515850129 1 GO:0008374 O-acyltransferase activity 11/3713 55/18639 0.2 1.00398599515217 0.547967432046814 1 GO:1902936 phosphatidylinositol bisphosphate binding 22/3713 111/18639 0.198198198198198 0.994941076276923 0.548702435784921 1 GO:0004065 arylsulfatase activity 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0005313 L-glutamate transmembrane transporter activity 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0008474 palmitoyl-(protein) hydrolase activity 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0008494 translation activator activity 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0032036 myosin heavy chain binding 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0044548 S100 protein binding 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0098599 palmitoyl hydrolase activity 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0098847 sequence-specific single stranded DNA binding 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:1990825 sequence-specific mRNA binding 3/3713 14/18639 0.214285714285714 1.07569928052018 0.549024863093699 1 GO:0071949 FAD binding 8/3713 40/18639 0.2 1.00398599515217 0.558019578277249 1 GO:0001618 virus receptor activity 16/3713 81/18639 0.197530864197531 0.991591106323129 0.559547644797611 1 GO:0005154 epidermal growth factor receptor binding 7/3713 35/18639 0.2 1.00398599515217 0.562643680953738 1 GO:0034061 DNA polymerase activity 7/3713 35/18639 0.2 1.00398599515217 0.562643680953738 1 GO:0005201 extracellular matrix structural constituent 33/3713 168/18639 0.196428571428571 0.986057673810165 0.567058739709423 1 GO:0001965 G-protein alpha-subunit binding 6/3713 30/18639 0.2 1.00398599515217 0.568317037043051 1 GO:0016597 amino acid binding 10/3713 51/18639 0.196078431372549 0.984299995247224 0.578184199677348 1 GO:0008081 phosphoric diester hydrolase activity 17/3713 87/18639 0.195402298850575 0.980905857332578 0.578317253904796 1 GO:0140272 exogenous protein binding 16/3713 82/18639 0.195121951219512 0.979498531855774 0.581074742302219 1 GO:0022853 active monoatomic ion transmembrane transporter activity 23/3713 118/18639 0.194915254237288 0.978460927478808 0.583405880065816 1 GO:0008017 microtubule binding 54/3713 276/18639 0.195652173913043 0.98216021264886 0.583427626717982 1 GO:0001972 retinoic acid binding 4/3713 20/18639 0.2 1.00398599515217 0.585171438158848 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/3713 20/18639 0.2 1.00398599515217 0.585171438158848 1 GO:0016408 C-acyltransferase activity 4/3713 20/18639 0.2 1.00398599515217 0.585171438158848 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/3713 20/18639 0.2 1.00398599515217 0.585171438158848 1 GO:0061608 nuclear import signal receptor activity 4/3713 20/18639 0.2 1.00398599515217 0.585171438158848 1 GO:0004812 aminoacyl-tRNA ligase activity 8/3713 41/18639 0.195121951219512 0.979498531855774 0.588330815462031 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 8/3713 41/18639 0.195121951219512 0.979498531855774 0.588330815462031 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 8/3713 41/18639 0.195121951219512 0.979498531855774 0.588330815462031 1 GO:0042169 SH2 domain binding 8/3713 41/18639 0.195121951219512 0.979498531855774 0.588330815462031 1 GO:0004129 cytochrome-c oxidase activity 3/3713 15/18639 0.2 1.00398599515217 0.599071360750022 1 GO:0004559 alpha-mannosidase activity 3/3713 15/18639 0.2 1.00398599515217 0.599071360750022 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 3/3713 15/18639 0.2 1.00398599515217 0.599071360750022 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/3713 15/18639 0.2 1.00398599515217 0.599071360750022 1 GO:0061578 K63-linked deubiquitinase activity 3/3713 15/18639 0.2 1.00398599515217 0.599071360750022 1 GO:0140776 protein-containing complex destabilizing activity 3/3713 15/18639 0.2 1.00398599515217 0.599071360750022 1 GO:0016504 peptidase activator activity 11/3713 57/18639 0.192982456140351 0.968758416374899 0.599615253563947 1 GO:0099106 ion channel regulator activity 31/3713 160/18639 0.19375 0.972611432803663 0.600440929210971 1 GO:0001540 amyloid-beta binding 16/3713 83/18639 0.192771084337349 0.967697344724981 0.602172464488814 1 GO:0004857 enzyme inhibitor activity 81/3713 416/18639 0.194711538461538 0.977438288549587 0.611496387737136 1 GO:0052742 phosphatidylinositol kinase activity 5/3713 26/18639 0.192307692307692 0.965371149184777 0.612926720083129 1 GO:0070006 metalloaminopeptidase activity 5/3713 26/18639 0.192307692307692 0.965371149184777 0.612926720083129 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 13/3713 68/18639 0.191176470588235 0.959692495366043 0.614099927178444 1 GO:0032934 sterol binding 13/3713 68/18639 0.191176470588235 0.959692495366043 0.614099927178444 1 GO:0140223 general transcription initiation factor activity 13/3713 68/18639 0.191176470588235 0.959692495366043 0.614099927178444 1 GO:0042056 chemoattractant activity 8/3713 42/18639 0.19047619047619 0.95617713824016 0.617600938547864 1 GO:0005507 copper ion binding 12/3713 63/18639 0.19047619047619 0.95617713824016 0.618945736579684 1 GO:0000182 rDNA binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0004382 GDP phosphatase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0005131 growth hormone receptor binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0005522 profilin binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0008401 retinoic acid 4-hydroxylase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0015203 polyamine transmembrane transporter activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0016868 intramolecular phosphotransferase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0031996 thioesterase binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0033204 ribonuclease P RNA binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0035256 G protein-coupled glutamate receptor binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0035374 chondroitin sulfate binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0042975 peroxisome proliferator activated receptor binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0047429 nucleoside triphosphate diphosphatase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0070097 delta-catenin binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0070513 death domain binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0070739 protein-glutamic acid ligase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0070740 tubulin-glutamic acid ligase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0098505 G-rich strand telomeric DNA binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0140135 mechanosensitive monoatomic cation channel activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0140999 histone H3K4 trimethyltransferase activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0141109 transporter activator activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:1905394 retromer complex binding 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:1990757 ubiquitin ligase activator activity 2/3713 10/18639 0.2 1.00398599515217 0.621852204494359 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/3713 21/18639 0.19047619047619 0.95617713824016 0.62630559189267 1 GO:0019200 carbohydrate kinase activity 4/3713 21/18639 0.19047619047619 0.95617713824016 0.62630559189267 1 GO:0030515 snoRNA binding 6/3713 32/18639 0.1875 0.941236870455158 0.63578811413067 1 GO:0071813 lipoprotein particle binding 6/3713 32/18639 0.1875 0.941236870455158 0.63578811413067 1 GO:0071814 protein-lipid complex binding 6/3713 32/18639 0.1875 0.941236870455158 0.63578811413067 1 GO:0009055 electron transfer activity 22/3713 116/18639 0.189655172413793 0.95205568505809 0.638546561412534 1 GO:0004536 DNA nuclease activity 12/3713 64/18639 0.1875 0.941236870455158 0.642109905083857 1 GO:0016247 channel regulator activity 32/3713 168/18639 0.19047619047619 0.95617713824016 0.642421583721025 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0008296 3'-5'-DNA exonuclease activity 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0015923 mannosidase activity 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0017070 U6 snRNA binding 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0055102 lipase inhibitor activity 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0140327 flippase activity 3/3713 16/18639 0.1875 0.941236870455158 0.645314017002896 1 GO:0008200 ion channel inhibitor activity 8/3713 43/18639 0.186046511627907 0.933940460606668 0.645727453985466 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/3713 43/18639 0.186046511627907 0.933940460606668 0.645727453985466 1 GO:0017069 snRNA binding 10/3713 54/18639 0.185185185185185 0.929616662177933 0.655353740541305 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 16/3713 86/18639 0.186046511627907 0.933940460606668 0.662441314974137 1 GO:0050660 flavin adenine dinucleotide binding 16/3713 86/18639 0.186046511627907 0.933940460606668 0.662441314974137 1 GO:0004407 histone deacetylase activity 4/3713 22/18639 0.181818181818182 0.912714541047426 0.664735101740872 1 GO:0016881 acid-amino acid ligase activity 4/3713 22/18639 0.181818181818182 0.912714541047426 0.664735101740872 1 GO:0031683 G-protein beta/gamma-subunit complex binding 4/3713 22/18639 0.181818181818182 0.912714541047426 0.664735101740872 1 GO:0033558 protein lysine deacetylase activity 4/3713 22/18639 0.181818181818182 0.912714541047426 0.664735101740872 1 GO:0030296 protein tyrosine kinase activator activity 6/3713 33/18639 0.181818181818182 0.912714541047426 0.667064717161324 1 GO:0015101 organic cation transmembrane transporter activity 15/3713 81/18639 0.185185185185185 0.929616662177933 0.667578979435393 1 GO:0141108 transporter regulator activity 32/3713 170/18639 0.188235294117647 0.944927995437335 0.670337707342148 1 GO:0003954 NADH dehydrogenase activity 8/3713 44/18639 0.181818181818182 0.912714541047426 0.672629555810525 1 GO:0016248 channel inhibitor activity 8/3713 44/18639 0.181818181818182 0.912714541047426 0.672629555810525 1 GO:0005536 D-glucose binding 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0010854 adenylate cyclase regulator activity 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0015173 aromatic amino acid transmembrane transporter activity 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0019215 intermediate filament binding 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0034056 estrogen response element binding 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0034511 U3 snoRNA binding 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0035252 UDP-xylosyltransferase activity 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0042285 xylosyltransferase activity 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0045294 alpha-catenin binding 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0097493 structural molecule activity conferring elasticity 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/3713 11/18639 0.181818181818182 0.912714541047426 0.67560601367081 1 GO:0005496 steroid binding 20/3713 108/18639 0.185185185185185 0.929616662177933 0.680043263965356 1 GO:0050698 proteoglycan sulfotransferase activity 5/3713 28/18639 0.178571428571429 0.89641606710015 0.681587567072977 1 GO:0004550 nucleoside diphosphate kinase activity 3/3713 17/18639 0.176470588235294 0.885869995722501 0.687634449199589 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/3713 17/18639 0.176470588235294 0.885869995722501 0.687634449199589 1 GO:0019198 transmembrane receptor protein phosphatase activity 3/3713 17/18639 0.176470588235294 0.885869995722501 0.687634449199589 1 GO:0030169 low-density lipoprotein particle binding 3/3713 17/18639 0.176470588235294 0.885869995722501 0.687634449199589 1 GO:0015297 antiporter activity 25/3713 135/18639 0.185185185185185 0.929616662177933 0.691955008376404 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 11/3713 61/18639 0.180327868852459 0.905233274317529 0.693627128180393 1 GO:0090482 vitamin transmembrane transporter activity 6/3713 34/18639 0.176470588235294 0.885869995722501 0.69658221839417 1 GO:0141110 transporter inhibitor activity 8/3713 45/18639 0.177777777777778 0.892431995690816 0.698246992976439 1 GO:0004602 glutathione peroxidase activity 4/3713 23/18639 0.173913043478261 0.87303130013232 0.700367381581238 1 GO:0043274 phospholipase binding 4/3713 23/18639 0.173913043478261 0.87303130013232 0.700367381581238 1 GO:0002020 protease binding 25/3713 136/18639 0.183823529411765 0.922781245544272 0.706591214494501 1 GO:0004177 aminopeptidase activity 7/3713 40/18639 0.175 0.878487745758147 0.71014011265387 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/3713 40/18639 0.175 0.878487745758147 0.71014011265387 1 GO:0050997 quaternary ammonium group binding 7/3713 40/18639 0.175 0.878487745758147 0.71014011265387 1 GO:0043236 laminin binding 5/3713 29/18639 0.172413793103448 0.865505168234628 0.71266858792558 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0003995 acyl-CoA dehydrogenase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0004000 adenosine deaminase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0004526 ribonuclease P activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0005436 sodium:phosphate symporter activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0016208 AMP binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0016273 arginine N-methyltransferase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0016274 protein-arginine N-methyltransferase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0016423 tRNA (guanine) methyltransferase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0016840 carbon-nitrogen lyase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0017166 vinculin binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0034452 dynactin binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0035251 UDP-glucosyltransferase activity 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0042301 phosphate ion binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0045295 gamma-catenin binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0097371 MDM2/MDM4 family protein binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0097677 STAT family protein binding 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/3713 12/18639 0.166666666666667 0.83665499596014 0.722955709216958 1 GO:0016854 racemase and epimerase activity 3/3713 18/18639 0.166666666666667 0.83665499596014 0.726042063288981 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/3713 18/18639 0.166666666666667 0.83665499596014 0.726042063288981 1 GO:0034185 apolipoprotein binding 3/3713 18/18639 0.166666666666667 0.83665499596014 0.726042063288981 1 GO:0050811 GABA receptor binding 3/3713 18/18639 0.166666666666667 0.83665499596014 0.726042063288981 1 GO:0005315 phosphate transmembrane transporter activity 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0030215 semaphorin receptor binding 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0030552 cAMP binding 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0070300 phosphatidic acid binding 4/3713 24/18639 0.166666666666667 0.83665499596014 0.733180335756001 1 GO:0017080 sodium channel regulator activity 7/3713 41/18639 0.170731707317073 0.857061215373802 0.735218497369837 1 GO:0003678 DNA helicase activity 13/3713 74/18639 0.175675675675676 0.881879590336364 0.7376990791702 1 GO:0048029 monosaccharide binding 13/3713 74/18639 0.175675675675676 0.881879590336364 0.7376990791702 1 GO:0140938 histone H3 methyltransferase activity 8/3713 47/18639 0.170212765957447 0.854456166086952 0.745480983280653 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 8/3713 47/18639 0.170212765957447 0.854456166086952 0.745480983280653 1 GO:0016279 protein-lysine N-methyltransferase activity 12/3713 69/18639 0.173913043478261 0.87303130013232 0.745698749562858 1 GO:0045505 dynein intermediate chain binding 6/3713 36/18639 0.166666666666667 0.83665499596014 0.750181614981113 1 GO:0005544 calcium-dependent phospholipid binding 9/3713 53/18639 0.169811320754717 0.852440939280143 0.755134485250234 1 GO:0008146 sulfotransferase activity 9/3713 53/18639 0.169811320754717 0.852440939280143 0.755134485250234 1 GO:0031492 nucleosomal DNA binding 7/3713 42/18639 0.166666666666667 0.83665499596014 0.758742009134232 1 GO:0031420 alkali metal ion binding 3/3713 19/18639 0.157894736842105 0.792620522488554 0.760641865952523 1 GO:0001848 complement binding 4/3713 25/18639 0.16 0.803188796121735 0.763208954453918 1 GO:0008483 transaminase activity 4/3713 25/18639 0.16 0.803188796121735 0.763208954453918 1 GO:0047617 fatty acyl-CoA hydrolase activity 4/3713 25/18639 0.16 0.803188796121735 0.763208954453918 1 GO:0016278 lysine N-methyltransferase activity 12/3713 70/18639 0.171428571428571 0.860559424416144 0.763781731020965 1 GO:0016782 transferase activity, transferring sulphur-containing groups 12/3713 70/18639 0.171428571428571 0.860559424416144 0.763781731020965 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0008035 high-density lipoprotein particle binding 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0008417 fucosyltransferase activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0019104 DNA N-glycosylase activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0030955 potassium ion binding 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0031432 titin binding 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0039706 co-receptor binding 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0046975 histone H3K36 methyltransferase activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0070700 BMP receptor binding 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0071714 icosanoid transmembrane transporter activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/3713 13/18639 0.153846153846154 0.772296919347822 0.76431901226774 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 8/3713 48/18639 0.166666666666667 0.83665499596014 0.767066197338178 1 GO:0036121 double-stranded DNA helicase activity 8/3713 48/18639 0.166666666666667 0.83665499596014 0.767066197338178 1 GO:0043138 3'-5' DNA helicase activity 8/3713 48/18639 0.166666666666667 0.83665499596014 0.767066197338178 1 GO:0005164 tumor necrosis factor receptor binding 5/3713 31/18639 0.161290322580645 0.809666125122716 0.768213118512812 1 GO:0047499 calcium-independent phospholipase A2 activity 5/3713 31/18639 0.161290322580645 0.809666125122716 0.768213118512812 1 GO:0030551 cyclic nucleotide binding 6/3713 37/18639 0.162162162162162 0.814042698772028 0.774254357232355 1 GO:0015485 cholesterol binding 9/3713 54/18639 0.166666666666667 0.83665499596014 0.77509063419202 1 GO:0008375 acetylglucosaminyltransferase activity 7/3713 43/18639 0.162790697674419 0.817197903030835 0.780717061524269 1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 10/3713 60/18639 0.166666666666667 0.83665499596014 0.782793375174228 1 GO:0005112 Notch binding 4/3713 26/18639 0.153846153846154 0.772296919347822 0.790532997066789 1 GO:0016289 acyl-CoA hydrolase activity 4/3713 26/18639 0.153846153846154 0.772296919347822 0.790532997066789 1 GO:0030247 polysaccharide binding 4/3713 26/18639 0.153846153846154 0.772296919347822 0.790532997066789 1 GO:0051139 metal cation:proton antiporter activity 4/3713 26/18639 0.153846153846154 0.772296919347822 0.790532997066789 1 GO:0004222 metalloendopeptidase activity 19/3713 110/18639 0.172727272727273 0.867078813995054 0.79078601591802 1 GO:0042288 MHC class I protein binding 3/3713 20/18639 0.15 0.752989496364126 0.791607235563172 1 GO:0140664 ATP-dependent DNA damage sensor activity 3/3713 20/18639 0.15 0.752989496364126 0.791607235563172 1 GO:0140939 histone H4 methyltransferase activity 3/3713 20/18639 0.15 0.752989496364126 0.791607235563172 1 GO:0008378 galactosyltransferase activity 5/3713 32/18639 0.15625 0.784364058712631 0.792736267472468 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/3713 32/18639 0.15625 0.784364058712631 0.792736267472468 1 GO:0047498 calcium-dependent phospholipase A2 activity 5/3713 32/18639 0.15625 0.784364058712631 0.792736267472468 1 GO:0001664 G protein-coupled receptor binding 54/3713 297/18639 0.181818181818182 0.912714541047426 0.795347786870632 1 GO:0008331 high voltage-gated calcium channel activity 2/3713 14/18639 0.142857142857143 0.71713285368012 0.800201370463414 1 GO:0008559 ABC-type xenobiotic transporter activity 2/3713 14/18639 0.142857142857143 0.71713285368012 0.800201370463414 1 GO:0015926 glucosidase activity 2/3713 14/18639 0.142857142857143 0.71713285368012 0.800201370463414 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/3713 14/18639 0.142857142857143 0.71713285368012 0.800201370463414 1 GO:0043176 amine binding 2/3713 14/18639 0.142857142857143 0.71713285368012 0.800201370463414 1 GO:0015026 coreceptor activity 10/3713 61/18639 0.163934426229508 0.822939340288662 0.800276953016157 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 21/3713 122/18639 0.172131147540984 0.864086307303095 0.804930566221405 1 GO:0032813 tumor necrosis factor receptor superfamily binding 8/3713 50/18639 0.16 0.803188796121735 0.806202426033042 1 GO:0042054 histone methyltransferase activity 11/3713 67/18639 0.164179104477612 0.824167607960735 0.806541041509828 1 GO:0030170 pyridoxal phosphate binding 9/3713 56/18639 0.160714285714286 0.806774460390135 0.811424072969565 1 GO:0019956 chemokine binding 5/3713 33/18639 0.151515151515152 0.760595450872855 0.815177615742315 1 GO:0005178 integrin binding 28/3713 161/18639 0.173913043478261 0.87303130013232 0.816692254613775 1 GO:0001846 opsonin binding 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0005123 death receptor binding 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0008373 sialyltransferase activity 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0015174 basic amino acid transmembrane transporter activity 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0061891 calcium ion sensor activity 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0070182 DNA polymerase binding 3/3713 21/18639 0.142857142857143 0.71713285368012 0.819157509508255 1 GO:0070279 vitamin B6 binding 9/3713 57/18639 0.157894736842105 0.792620522488554 0.82784189291711 1 GO:0072341 modified amino acid binding 15/3713 91/18639 0.164835164835165 0.827460985015523 0.829650002747748 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0005041 low-density lipoprotein particle receptor activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0008242 omega peptidase activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0010181 FMN binding 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0017081 chloride channel regulator activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0030553 cGMP binding 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0034483 heparan sulfate sulfotransferase activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0045504 dynein heavy chain binding 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0047372 monoacylglycerol lipase activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0141050 histone H3K deacetylase activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0141051 histone H4K deacetylase activity 2/3713 15/18639 0.133333333333333 0.669323996768112 0.831144448880858 1 GO:0042277 peptide binding 44/3713 249/18639 0.176706827309237 0.887055899331233 0.835041770052604 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 5/3713 34/18639 0.147058823529412 0.738224996435418 0.835625098043719 1 GO:0005242 inward rectifier potassium channel activity 4/3713 28/18639 0.142857142857143 0.71713285368012 0.837545744233343 1 GO:0016866 intramolecular transferase activity 4/3713 28/18639 0.142857142857143 0.71713285368012 0.837545744233343 1 GO:0045499 chemorepellent activity 4/3713 28/18639 0.142857142857143 0.71713285368012 0.837545744233343 1 GO:0046625 sphingolipid binding 4/3713 28/18639 0.142857142857143 0.71713285368012 0.837545744233343 1 GO:0051959 dynein light intermediate chain binding 4/3713 28/18639 0.142857142857143 0.71713285368012 0.837545744233343 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/3713 46/18639 0.152173913043478 0.76390238761578 0.837640287860345 1 GO:0005516 calmodulin binding 36/3713 207/18639 0.173913043478261 0.87303130013232 0.842376782256652 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 9/3713 58/18639 0.155172413793103 0.778954651411165 0.843133261715129 1 GO:0017116 single-stranded DNA helicase activity 9/3713 58/18639 0.155172413793103 0.778954651411165 0.843133261715129 1 GO:0008970 phospholipase A1 activity 3/3713 22/18639 0.136363636363636 0.684535905785569 0.84353999494521 1 GO:0140784 metal ion sensor activity 3/3713 22/18639 0.136363636363636 0.684535905785569 0.84353999494521 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 31/3713 181/18639 0.171270718232044 0.859767012423127 0.851103605995709 1 GO:0001727 lipid kinase activity 6/3713 41/18639 0.146341463414634 0.73462389889183 0.853235835323495 1 GO:0005506 iron ion binding 26/3713 154/18639 0.168831168831169 0.847520645258324 0.85354715932535 1 GO:0005504 fatty acid binding 7/3713 47/18639 0.148936170212766 0.747649145326083 0.853768166161791 1 GO:0061749 forked DNA-dependent helicase activity 7/3713 47/18639 0.148936170212766 0.747649145326083 0.853768166161791 1 GO:0004623 phospholipase A2 activity 5/3713 35/18639 0.142857142857143 0.71713285368012 0.854180341062077 1 GO:0005343 organic acid:sodium symporter activity 5/3713 35/18639 0.142857142857143 0.71713285368012 0.854180341062077 1 GO:0016229 steroid dehydrogenase activity 5/3713 35/18639 0.142857142857143 0.71713285368012 0.854180341062077 1 GO:0017046 peptide hormone binding 8/3713 53/18639 0.150943396226415 0.757725279360127 0.855243792735262 1 GO:0035250 UDP-galactosyltransferase activity 4/3713 29/18639 0.137931034482759 0.692404134587702 0.857526089242585 1 GO:0022841 potassium ion leak channel activity 2/3713 16/18639 0.125 0.627491246970105 0.857691653434853 1 GO:0038024 cargo receptor activity 10/3713 65/18639 0.153846153846154 0.772296919347822 0.85983227123992 1 GO:0042562 hormone binding 15/3713 94/18639 0.159574468085106 0.801052655706517 0.864472134056897 1 GO:0140103 catalytic activity, acting on a glycoprotein 3/3713 23/18639 0.130434782608696 0.65477347509924 0.865015886949806 1 GO:0009378 four-way junction helicase activity 7/3713 48/18639 0.145833333333333 0.732073121465122 0.868570941326798 1 GO:0005319 lipid transporter activity 30/3713 178/18639 0.168539325842697 0.846055613892276 0.870649755768519 1 GO:0004190 aspartic-type endopeptidase activity 5/3713 36/18639 0.138888888888889 0.69721249663345 0.870954329139652 1 GO:0022804 active transmembrane transporter activity 82/3713 457/18639 0.179431072210066 0.900731417970216 0.871702419293008 1 GO:0016769 transferase activity, transferring nitrogenous groups 4/3713 30/18639 0.133333333333333 0.669323996768112 0.875370272494969 1 GO:0015278 intracellularly gated calcium channel activity 2/3713 17/18639 0.117647058823529 0.590579997148334 0.880365947332889 1 GO:0016805 dipeptidase activity 2/3713 17/18639 0.117647058823529 0.590579997148334 0.880365947332889 1 GO:0017110 nucleoside diphosphate phosphatase activity 2/3713 17/18639 0.117647058823529 0.590579997148334 0.880365947332889 1 GO:0030548 acetylcholine receptor regulator activity 2/3713 17/18639 0.117647058823529 0.590579997148334 0.880365947332889 1 GO:0045125 bioactive lipid receptor activity 2/3713 17/18639 0.117647058823529 0.590579997148334 0.880365947332889 1 GO:0070402 NADPH binding 2/3713 17/18639 0.117647058823529 0.590579997148334 0.880365947332889 1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 10/3713 67/18639 0.149253731343284 0.749243279964305 0.883803174401536 1 GO:0015295 solute:proton symporter activity 3/3713 24/18639 0.125 0.627491246970105 0.883849537120349 1 GO:0070840 dynein complex binding 3/3713 24/18639 0.125 0.627491246970105 0.883849537120349 1 GO:0004896 cytokine receptor activity 15/3713 96/18639 0.15625 0.784364058712631 0.884416254619653 1 GO:0019213 deacetylase activity 5/3713 37/18639 0.135135135135135 0.678368915643357 0.886063699750167 1 GO:0043394 proteoglycan binding 5/3713 37/18639 0.135135135135135 0.678368915643357 0.886063699750167 1 GO:0070001 aspartic-type peptidase activity 5/3713 37/18639 0.135135135135135 0.678368915643357 0.886063699750167 1 GO:0033293 monocarboxylic acid binding 12/3713 79/18639 0.151898734177215 0.76252100897633 0.887140767485563 1 GO:0016758 hexosyltransferase activity 33/3713 197/18639 0.16751269035533 0.840901975635065 0.888539858367235 1 GO:0016411 acylglycerol O-acyltransferase activity 4/3713 31/18639 0.129032258064516 0.647732900098173 0.891245406418252 1 GO:0016878 acid-thiol ligase activity 4/3713 31/18639 0.129032258064516 0.647732900098173 0.891245406418252 1 GO:0072349 modified amino acid transmembrane transporter activity 4/3713 31/18639 0.129032258064516 0.647732900098173 0.891245406418252 1 GO:0001094 TFIID-class transcription factor complex binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0004935 adrenergic receptor activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0005031 tumor necrosis factor receptor activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0008190 eukaryotic initiation factor 4E binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0008239 dipeptidyl-peptidase activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0015187 glycine transmembrane transporter activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0015643 toxic substance binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0019911 structural constituent of myelin sheath 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0031419 cobalamin binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0032052 bile acid binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0043121 neurotrophin binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0051378 serotonin binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0097177 mitochondrial ribosome binding 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0140940 histone H2A methyltransferase activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/3713 10/18639 0.1 0.501992997576084 0.891620445644175 1 GO:0031406 carboxylic acid binding 31/3713 187/18639 0.165775401069519 0.832180905072653 0.895039952937262 1 GO:0005253 monoatomic anion channel activity 16/3713 103/18639 0.155339805825243 0.779794947691004 0.89573833928178 1 GO:0016790 thiolester hydrolase activity 6/3713 44/18639 0.136363636363636 0.684535905785569 0.896266775592434 1 GO:0004620 phospholipase activity 17/3713 109/18639 0.155963302752294 0.782924858604902 0.898041003611476 1 GO:0016209 antioxidant activity 13/3713 86/18639 0.151162790697674 0.758826624242918 0.898393368993742 1 GO:0000146 microfilament motor activity 5/3713 38/18639 0.131578947368421 0.660517102073795 0.899627639986801 1 GO:0042887 amide transmembrane transporter activity 5/3713 38/18639 0.131578947368421 0.660517102073795 0.899627639986801 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/3713 18/18639 0.111111111111111 0.55776999730676 0.899656432838377 1 GO:0030228 lipoprotein particle receptor activity 2/3713 18/18639 0.111111111111111 0.55776999730676 0.899656432838377 1 GO:0099602 neurotransmitter receptor regulator activity 2/3713 18/18639 0.111111111111111 0.55776999730676 0.899656432838377 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 21/3713 132/18639 0.159090909090909 0.798625223416497 0.900251326858306 1 GO:0005251 delayed rectifier potassium channel activity 3/3713 25/18639 0.12 0.602391597091301 0.900300525665772 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/3713 25/18639 0.12 0.602391597091301 0.900300525665772 1 GO:0120015 sterol transfer activity 4/3713 32/18639 0.125 0.627491246970105 0.905318140553364 1 GO:0043177 organic acid binding 31/3713 189/18639 0.164021164021164 0.823374757929027 0.907177721045934 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0000099 sulfur amino acid transmembrane transporter activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0001851 complement component C3b binding 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0008046 axon guidance receptor activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0008199 ferric iron binding 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0008503 benzodiazepine receptor activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0008526 phosphatidylinositol transfer activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0032794 GTPase activating protein binding 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0050786 RAGE receptor binding 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:1990948 ubiquitin ligase inhibitor activity 1/3713 11/18639 0.0909090909090909 0.456357270523713 0.913221888841511 1 GO:0004435 phosphatidylinositol phospholipase C activity 3/3713 26/18639 0.115384615384615 0.579222689510866 0.914618029396074 1 GO:0004529 DNA exonuclease activity 3/3713 26/18639 0.115384615384615 0.579222689510866 0.914618029396074 1 GO:0005227 calcium-activated cation channel activity 3/3713 26/18639 0.115384615384615 0.579222689510866 0.914618029396074 1 GO:0030507 spectrin binding 3/3713 26/18639 0.115384615384615 0.579222689510866 0.914618029396074 1 GO:0120014 phospholipid transfer activity 3/3713 26/18639 0.115384615384615 0.579222689510866 0.914618029396074 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0008381 mechanosensitive monoatomic ion channel activity 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0022840 leak channel activity 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0022842 narrow pore channel activity 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0030506 ankyrin binding 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0042834 peptidoglycan binding 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0043395 heparan sulfate proteoglycan binding 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0046527 glucosyltransferase activity 2/3713 19/18639 0.105263157894737 0.528413681659036 0.916011087766124 1 GO:0019239 deaminase activity 4/3713 33/18639 0.121212121212121 0.608476360698284 0.91775131638937 1 GO:0030276 clathrin binding 6/3713 46/18639 0.130434782608696 0.65477347509924 0.918532017360961 1 GO:0033218 amide binding 41/3713 247/18639 0.165991902834008 0.833267728770018 0.921122574084129 1 GO:0120013 lipid transfer activity 9/3713 65/18639 0.138461538461538 0.695067227413039 0.922209828553482 1 GO:0160215 deacylase activity 9/3713 65/18639 0.138461538461538 0.695067227413039 0.922209828553482 1 GO:0003735 structural constituent of ribosome 28/3713 175/18639 0.16 0.803188796121735 0.922276118844097 1 GO:0015459 potassium channel regulator activity 8/3713 59/18639 0.135593220338983 0.680668471289606 0.923302859035634 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/3713 59/18639 0.135593220338983 0.680668471289606 0.923302859035634 1 GO:0004864 protein phosphatase inhibitor activity 7/3713 53/18639 0.132075471698113 0.663009619440111 0.925152828831121 1 GO:0003774 cytoskeletal motor activity 24/3713 153/18639 0.156862745098039 0.787439996197779 0.92536645997746 1 GO:0004364 glutathione transferase activity 3/3713 27/18639 0.111111111111111 0.55776999730676 0.927037032490708 1 GO:0005044 scavenger receptor activity 3/3713 27/18639 0.111111111111111 0.55776999730676 0.927037032490708 1 GO:0023026 MHC class II protein complex binding 3/3713 27/18639 0.111111111111111 0.55776999730676 0.927037032490708 1 GO:0035255 ionotropic glutamate receptor binding 3/3713 27/18639 0.111111111111111 0.55776999730676 0.927037032490708 1 GO:0008376 acetylgalactosaminyltransferase activity 4/3713 34/18639 0.117647058823529 0.590579997148334 0.928701478835457 1 GO:0051427 hormone receptor binding 4/3713 34/18639 0.117647058823529 0.590579997148334 0.928701478835457 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/3713 20/18639 0.1 0.501992997576084 0.929833738010897 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/3713 20/18639 0.1 0.501992997576084 0.929833738010897 1 GO:0010851 cyclase regulator activity 2/3713 20/18639 0.1 0.501992997576084 0.929833738010897 1 GO:0030742 GTP-dependent protein binding 2/3713 20/18639 0.1 0.501992997576084 0.929833738010897 1 GO:0003720 telomerase activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0005165 neurotrophin receptor binding 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0008179 adenylate cyclase binding 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0008504 monoamine transmembrane transporter activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0010853 cyclase activator activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0015132 prostaglandin transmembrane transporter activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0015166 polyol transmembrane transporter activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0015269 calcium-activated potassium channel activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0070008 serine-type exopeptidase activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0140900 chloride:bicarbonate antiporter activity 1/3713 12/18639 0.0833333333333333 0.41832749798007 0.930518814261925 1 GO:0140828 metal cation:monoatomic cation antiporter activity 5/3713 41/18639 0.121951219512195 0.612186582409859 0.93222703360954 1 GO:0050661 NADP binding 7/3713 54/18639 0.12962962962963 0.650731663524553 0.933488690415046 1 GO:0046875 ephrin receptor binding 3/3713 28/18639 0.107142857142857 0.53784964026009 0.937775987081591 1 GO:0008237 metallopeptidase activity 29/3713 184/18639 0.157608695652174 0.791184615744915 0.938177903833375 1 GO:0008307 structural constituent of muscle 5/3713 42/18639 0.119047619047619 0.5976107114001 0.940773280535824 1 GO:0051428 peptide hormone receptor binding 2/3713 21/18639 0.0952380952380952 0.47808856912008 0.941483867326965 1 GO:0048306 calcium-dependent protein binding 11/3713 80/18639 0.1375 0.690240371667116 0.941968196750101 1 GO:1901681 sulfur compound binding 45/3713 275/18639 0.163636363636364 0.821443086942683 0.943858071415374 1 GO:0035254 glutamate receptor binding 6/3713 49/18639 0.122448979591837 0.614685303154389 0.944089488087698 1 GO:0002161 aminoacyl-tRNA editing activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0003964 RNA-directed DNA polymerase activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0004993 G protein-coupled serotonin receptor activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0005035 death receptor activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0005542 folic acid binding 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0008253 5'-nucleotidase activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0009982 pseudouridine synthase activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0035325 Toll-like receptor binding 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0051011 microtubule minus-end binding 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:1901338 catecholamine binding 1/3713 13/18639 0.0769230769230769 0.386148459673911 0.94436879776144 1 GO:0003785 actin monomer binding 3/3713 29/18639 0.103448275862069 0.519303100940777 0.9470355906784 1 GO:0004181 metallocarboxypeptidase activity 3/3713 29/18639 0.103448275862069 0.519303100940777 0.9470355906784 1 GO:0004629 phospholipase C activity 3/3713 29/18639 0.103448275862069 0.519303100940777 0.9470355906784 1 GO:0019212 phosphatase inhibitor activity 7/3713 56/18639 0.125 0.627491246970105 0.947743135002405 1 GO:0005245 voltage-gated calcium channel activity 5/3713 43/18639 0.116279069767442 0.583712787879167 0.948335752355541 1 GO:0015085 calcium ion transmembrane transporter activity 22/3713 147/18639 0.149659863945578 0.751282037188697 0.950783978645034 1 GO:0033691 sialic acid binding 2/3713 22/18639 0.0909090909090909 0.456357270523713 0.95127825456514 1 GO:0061133 endopeptidase activator activity 2/3713 22/18639 0.0909090909090909 0.456357270523713 0.95127825456514 1 GO:1901682 sulfur compound transmembrane transporter activity 8/3713 63/18639 0.126984126984127 0.63745142549344 0.951461328511074 1 GO:0005200 structural constituent of cytoskeleton 16/3713 112/18639 0.142857142857143 0.71713285368012 0.95177564840594 1 GO:0003779 actin binding 75/3713 443/18639 0.169300225733634 0.849875278063348 0.95324992110635 1 GO:0004601 peroxidase activity 7/3713 57/18639 0.12280701754386 0.616482628602208 0.95379241547986 1 GO:0020037 heme binding 21/3713 142/18639 0.147887323943662 0.742384010499843 0.953956943871213 1 GO:0022829 wide pore channel activity 4/3713 37/18639 0.108108108108108 0.542695132514685 0.954091851888712 1 GO:0022839 monoatomic ion-gated channel activity 3/3713 30/18639 0.1 0.501992997576084 0.954998403809892 1 GO:0098918 structural constituent of synapse 3/3713 30/18639 0.1 0.501992997576084 0.954998403809892 1 GO:0003730 mRNA 3'-UTR binding 42/3713 262/18639 0.16030534351145 0.804721599167768 0.95507029629584 1 GO:0015386 potassium:proton antiporter activity 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:0016530 metallochaperone activity 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:0031404 chloride ion binding 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:0034236 protein kinase A catalytic subunit binding 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:0042043 neurexin family protein binding 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:1901474 azole transmembrane transporter activity 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:1901612 cardiolipin binding 1/3713 14/18639 0.0714285714285714 0.35856642684006 0.955458599861288 1 GO:0008201 heparin binding 26/3713 172/18639 0.151162790697674 0.758826624242918 0.957388748602297 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/3713 23/18639 0.0869565217391304 0.43651565006616 0.959493718147553 1 GO:0099186 structural constituent of postsynapse 2/3713 23/18639 0.0869565217391304 0.43651565006616 0.959493718147553 1 GO:0008238 exopeptidase activity 14/3713 102/18639 0.137254901960784 0.689009996673057 0.960133892577582 1 GO:0015171 amino acid transmembrane transporter activity 14/3713 102/18639 0.137254901960784 0.689009996673057 0.960133892577582 1 GO:0042605 peptide antigen binding 5/3713 45/18639 0.111111111111111 0.55776999730676 0.960890054695497 1 GO:0005452 solute:inorganic anion antiporter activity 3/3713 31/18639 0.0967741935483871 0.48579967507363 0.961829082101854 1 GO:0004089 carbonate dehydratase activity 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0005523 tropomyosin binding 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0008252 nucleotidase activity 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0015116 sulfate transmembrane transporter activity 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0016846 carbon-sulfur lyase activity 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0048531 beta-1,3-galactosyltransferase activity 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0140161 monocarboxylate:sodium symporter activity 1/3713 15/18639 0.0666666666666667 0.334661998384056 0.964338182074176 1 GO:0004180 carboxypeptidase activity 5/3713 46/18639 0.108695652173913 0.5456445625827 0.966055669004587 1 GO:0008235 metalloexopeptidase activity 8/3713 66/18639 0.121212121212121 0.608476360698284 0.966103823732677 1 GO:0015149 hexose transmembrane transporter activity 2/3713 24/18639 0.0833333333333333 0.41832749798007 0.966370461877299 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/3713 24/18639 0.0833333333333333 0.41832749798007 0.966370461877299 1 GO:0019957 C-C chemokine binding 2/3713 24/18639 0.0833333333333333 0.41832749798007 0.966370461877299 1 GO:0055056 D-glucose transmembrane transporter activity 2/3713 24/18639 0.0833333333333333 0.41832749798007 0.966370461877299 1 GO:0046906 tetrapyrrole binding 22/3713 152/18639 0.144736842105263 0.726568812281174 0.967347202368262 1 GO:0015106 bicarbonate transmembrane transporter activity 3/3713 32/18639 0.09375 0.470618435227579 0.967675041572387 1 GO:0042910 xenobiotic transmembrane transporter activity 3/3713 32/18639 0.09375 0.470618435227579 0.967675041572387 1 GO:0008514 organic anion transmembrane transporter activity 42/3713 269/18639 0.156133828996283 0.783780888408756 0.971316535357925 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/3713 16/18639 0.0625 0.313745623485053 0.971447950650131 1 GO:0015378 sodium:chloride symporter activity 1/3713 16/18639 0.0625 0.313745623485053 0.971447950650131 1 GO:0015562 efflux transmembrane transporter activity 1/3713 16/18639 0.0625 0.313745623485053 0.971447950650131 1 GO:0015271 outward rectifier potassium channel activity 2/3713 25/18639 0.08 0.401594398060867 0.972115673721779 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/3713 25/18639 0.08 0.401594398060867 0.972115673721779 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/3713 25/18639 0.08 0.401594398060867 0.972115673721779 1 GO:0120020 cholesterol transfer activity 2/3713 25/18639 0.08 0.401594398060867 0.972115673721779 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/3713 33/18639 0.0909090909090909 0.456357270523713 0.972667414090689 1 GO:0015291 secondary active transmembrane transporter activity 45/3713 287/18639 0.156794425087108 0.787097034526961 0.973175367737816 1 GO:0003777 microtubule motor activity 8/3713 68/18639 0.117647058823529 0.590579997148334 0.973506286131715 1 GO:0005262 calcium channel activity 18/3713 131/18639 0.137404580152672 0.68976137071523 0.974705897935781 1 GO:0001530 lipopolysaccharide binding 4/3713 41/18639 0.0975609756097561 0.489749265927887 0.975080390399787 1 GO:0042287 MHC protein binding 4/3713 41/18639 0.0975609756097561 0.489749265927887 0.975080390399787 1 GO:0015145 monosaccharide transmembrane transporter activity 2/3713 26/18639 0.0769230769230769 0.386148459673911 0.976907144082255 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/3713 34/18639 0.0882352941176471 0.442934997861251 0.976922182018614 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/3713 34/18639 0.0882352941176471 0.442934997861251 0.976922182018614 1 GO:0051015 actin filament binding 31/3713 209/18639 0.148325358851675 0.744582915065005 0.976944648260575 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0008569 minus-end-directed microtubule motor activity 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0009881 photoreceptor activity 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0016018 cyclosporin A binding 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0036041 long-chain fatty acid binding 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0045236 CXCR chemokine receptor binding 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0070492 oligosaccharide binding 1/3713 17/18639 0.0588235294117647 0.295289998574167 0.977140575857459 1 GO:0008194 UDP-glycosyltransferase activity 20/3713 145/18639 0.137931034482759 0.692404134587702 0.978824891482612 1 GO:0005125 cytokine activity 35/3713 234/18639 0.14957264957265 0.750844227143715 0.979878234373807 1 GO:0016405 CoA-ligase activity 2/3713 27/18639 0.0740740740740741 0.371846664871173 0.980896753009578 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/3713 27/18639 0.0740740740740741 0.371846664871173 0.980896753009578 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/3713 18/18639 0.0555555555555556 0.27888499865338 0.981698466623287 1 GO:0015373 monoatomic anion:sodium symporter activity 1/3713 18/18639 0.0555555555555556 0.27888499865338 0.981698466623287 1 GO:0022851 GABA-gated chloride ion channel activity 1/3713 18/18639 0.0555555555555556 0.27888499865338 0.981698466623287 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/3713 18/18639 0.0555555555555556 0.27888499865338 0.981698466623287 1 GO:1901611 phosphatidylglycerol binding 1/3713 18/18639 0.0555555555555556 0.27888499865338 0.981698466623287 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/3713 36/18639 0.0833333333333333 0.41832749798007 0.983614493975092 1 GO:0051119 sugar transmembrane transporter activity 2/3713 28/18639 0.0714285714285714 0.35856642684006 0.984213735004039 1 GO:0016298 lipase activity 17/3713 130/18639 0.130769230769231 0.656452381445648 0.984606240224376 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 17/3713 130/18639 0.130769230769231 0.656452381445648 0.984606240224376 1 GO:0004890 GABA-A receptor activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0008301 DNA binding, bending 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0008574 plus-end-directed microtubule motor activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0015245 fatty acid transmembrane transporter activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0022821 solute:potassium antiporter activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0046624 sphingolipid transporter activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0070003 threonine-type peptidase activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0099589 serotonin receptor activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0141147 intracellularly calcium-gated channel activity 1/3713 19/18639 0.0526315789473684 0.264206840829518 0.985347765448685 1 GO:0023023 MHC protein complex binding 3/3713 37/18639 0.0810810810810811 0.407021349386014 0.986219432982714 1 GO:0051861 glycolipid binding 2/3713 29/18639 0.0689655172413793 0.346202067293851 0.986967671620753 1 GO:0099604 ligand-gated calcium channel activity 2/3713 29/18639 0.0689655172413793 0.346202067293851 0.986967671620753 1 GO:0001614 purinergic nucleotide receptor activity 1/3713 20/18639 0.05 0.250996498788042 0.988269556366463 1 GO:0016502 nucleotide receptor activity 1/3713 20/18639 0.05 0.250996498788042 0.988269556366463 1 GO:0030627 pre-mRNA 5'-splice site binding 1/3713 20/18639 0.05 0.250996498788042 0.988269556366463 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 10/3713 88/18639 0.113636363636364 0.570446588154641 0.988575890938891 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/3713 46/18639 0.0869565217391304 0.43651565006616 0.988760722180111 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/3713 30/18639 0.0666666666666667 0.334661998384056 0.9892511907501 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/3713 30/18639 0.0666666666666667 0.334661998384056 0.9892511907501 1 GO:0005248 voltage-gated sodium channel activity 1/3713 21/18639 0.0476190476190476 0.23904428456004 0.990608840818438 1 GO:0015125 bile acid transmembrane transporter activity 1/3713 21/18639 0.0476190476190476 0.23904428456004 0.990608840818438 1 GO:0005254 chloride channel activity 9/3713 83/18639 0.108433734939759 0.544329756407802 0.990797665691077 1 GO:0005184 neuropeptide hormone activity 2/3713 31/18639 0.0645161290322581 0.323866450049086 0.991142370656876 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/3713 31/18639 0.0645161290322581 0.323866450049086 0.991142370656876 1 GO:0005244 voltage-gated monoatomic ion channel activity 23/3713 173/18639 0.132947976878613 0.667389534349707 0.991471511031793 1 GO:0038187 pattern recognition receptor activity 4/3713 48/18639 0.0833333333333333 0.41832749798007 0.991897243087772 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 16/3713 130/18639 0.123076923076923 0.617837535478257 0.99199765859141 1 GO:0170055 lipid transmembrane transporter activity 5/3713 56/18639 0.0892857142857143 0.448208033550075 0.992380662327364 1 GO:0005243 gap junction channel activity 1/3713 22/18639 0.0454545454545455 0.228178635261856 0.992481725878119 1 GO:0015377 chloride:monoatomic cation symporter activity 1/3713 22/18639 0.0454545454545455 0.228178635261856 0.992481725878119 1 GO:0160041 neuropeptide activity 2/3713 32/18639 0.0625 0.313745623485053 0.992706859262508 1 GO:0022832 voltage-gated channel activity 23/3713 175/18639 0.131428571428571 0.65976222538571 0.992951326042456 1 GO:0052689 carboxylic ester hydrolase activity 10/3713 92/18639 0.108695652173913 0.5456445625827 0.993084286649839 1 GO:0015370 solute:sodium symporter activity 8/3713 79/18639 0.10126582278481 0.508347339317553 0.993744512771201 1 GO:0016493 C-C chemokine receptor activity 1/3713 23/18639 0.0434782608695652 0.21825782503308 0.993981180774963 1 GO:0016917 GABA receptor activity 1/3713 23/18639 0.0434782608695652 0.21825782503308 0.993981180774963 1 GO:0015020 glucuronosyltransferase activity 2/3713 34/18639 0.0588235294117647 0.295289998574167 0.995067073235094 1 GO:0019825 oxygen binding 2/3713 34/18639 0.0588235294117647 0.295289998574167 0.995067073235094 1 GO:0005272 sodium channel activity 4/3713 51/18639 0.0784313725490196 0.393719998098889 0.995080713485845 1 GO:0015294 solute:monoatomic cation symporter activity 13/3713 116/18639 0.112068965517241 0.562578359352508 0.995729392180137 1 GO:0008509 monoatomic anion transmembrane transporter activity 18/3713 149/18639 0.120805369127517 0.606434493716075 0.995926346015738 1 GO:0005539 glycosaminoglycan binding 33/3713 242/18639 0.136363636363636 0.684535905785569 0.995964548080608 1 GO:0005537 D-mannose binding 1/3713 25/18639 0.04 0.200797199030434 0.996142729026168 1 GO:0015645 fatty acid ligase activity 1/3713 25/18639 0.04 0.200797199030434 0.996142729026168 1 GO:0120515 fatty acid-CoA ligase activity 1/3713 25/18639 0.04 0.200797199030434 0.996142729026168 1 GO:0004033 aldo-keto reductase (NADPH) activity 2/3713 36/18639 0.0555555555555556 0.27888499865338 0.996672882646282 1 GO:0061134 peptidase regulator activity 30/3713 226/18639 0.132743362831858 0.666362386162944 0.996695289587389 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 9/3713 91/18639 0.0989010989010989 0.496476591009314 0.996837646277742 1 GO:0001637 G protein-coupled chemoattractant receptor activity 1/3713 26/18639 0.0384615384615385 0.193074229836955 0.996912152423924 1 GO:0004950 chemokine receptor activity 1/3713 26/18639 0.0384615384615385 0.193074229836955 0.996912152423924 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/3713 70/18639 0.0857142857142857 0.430279712208072 0.997207464652783 1 GO:0015293 symporter activity 17/3713 146/18639 0.116438356164384 0.584512394437906 0.997225845965117 1 GO:0030280 structural constituent of skin epidermis 2/3713 37/18639 0.0540540540540541 0.271347566257343 0.997270222627058 1 GO:0015078 proton transmembrane transporter activity 23/3713 185/18639 0.124324324324324 0.624099402391888 0.997392243446287 1 GO:0008395 steroid hydroxylase activity 1/3713 27/18639 0.037037037037037 0.185923332435587 0.997528129324476 1 GO:0015252 proton channel activity 1/3713 27/18639 0.037037037037037 0.185923332435587 0.997528129324476 1 GO:0008188 neuropeptide receptor activity 3/3713 48/18639 0.0625 0.313745623485053 0.998083243118813 1 GO:0046943 carboxylic acid transmembrane transporter activity 23/3713 188/18639 0.122340425531915 0.614140369374996 0.998089563839933 1 GO:0004867 serine-type endopeptidase inhibitor activity 9/3713 95/18639 0.0947368421052632 0.475572313493132 0.998186942896513 1 GO:0005342 organic acid transmembrane transporter activity 23/3713 189/18639 0.121693121693122 0.610890949431213 0.998279954014605 1 GO:0015144 carbohydrate transmembrane transporter activity 2/3713 40/18639 0.05 0.250996498788042 0.99849765942305 1 GO:0071855 neuropeptide receptor binding 2/3713 40/18639 0.05 0.250996498788042 0.99849765942305 1 GO:0004175 endopeptidase activity 58/3713 405/18639 0.14320987654321 0.718903552084268 0.998743021556921 1 GO:0008227 G protein-coupled amine receptor activity 2/3713 41/18639 0.0487804878048781 0.244874632963943 0.998770181100938 1 GO:0005249 voltage-gated potassium channel activity 9/3713 98/18639 0.0918367346938776 0.461013977365792 0.998815912309478 1 GO:0004497 monooxygenase activity 10/3713 106/18639 0.0943396226415094 0.473578299600079 0.998938104484307 1 GO:0004866 endopeptidase inhibitor activity 18/3713 161/18639 0.111801242236025 0.56123440722792 0.998950205329296 1 GO:0001653 peptide receptor activity 13/3713 128/18639 0.1015625 0.50983663816321 0.999052939045982 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/3713 52/18639 0.0576923076923077 0.289611344755433 0.99908750991142 1 GO:0030414 peptidase inhibitor activity 19/3713 169/18639 0.112426035502959 0.564370825677254 0.999106611275063 1 GO:0008528 G protein-coupled peptide receptor activity 12/3713 122/18639 0.0983606557377049 0.493763604173197 0.999168229720778 1 GO:0042923 neuropeptide binding 1/3713 33/18639 0.0303030303030303 0.152119090174571 0.999349686219663 1 GO:0099095 ligand-gated monoatomic anion channel activity 2/3713 47/18639 0.0425531914893617 0.213614041521738 0.999633597916406 1 GO:0030246 carbohydrate binding 35/3713 280/18639 0.125 0.627491246970105 0.999634013676765 1 GO:0061135 endopeptidase regulator activity 20/3713 184/18639 0.108695652173913 0.5456445625827 0.999665137661731 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/3713 36/18639 0.0277777777777778 0.13944249932669 0.999666502167393 1 GO:0022843 voltage-gated monoatomic cation channel activity 14/3713 143/18639 0.0979020979020979 0.491461675948614 0.999669518931843 1 GO:0005267 potassium channel activity 11/3713 124/18639 0.0887096774193548 0.445316368817494 0.999767591482323 1 GO:0048020 CCR chemokine receptor binding 2/3713 50/18639 0.04 0.200797199030434 0.999801123058645 1 GO:0140375 immune receptor activity 15/3713 156/18639 0.0961538461538462 0.482685574592389 0.999850133988482 1 GO:0015108 chloride transmembrane transporter activity 10/3713 121/18639 0.0826446280991736 0.414870245930648 0.999879268321015 1 GO:0015103 inorganic anion transmembrane transporter activity 16/3713 165/18639 0.096969696969697 0.486781088558627 0.999884128673922 1 GO:0005179 hormone activity 11/3713 132/18639 0.0833333333333333 0.41832749798007 0.999927653112322 1 GO:0015081 sodium ion transmembrane transporter activity 15/3713 164/18639 0.0914634146341463 0.459139936807394 0.99994941602404 1 GO:0046873 metal ion transmembrane transporter activity 59/3713 450/18639 0.131111111111111 0.658168596821977 0.999951642604774 1 GO:0004252 serine-type endopeptidase activity 16/3713 176/18639 0.0909090909090909 0.456357270523713 0.999973789549289 1 GO:0042379 chemokine receptor binding 3/3713 72/18639 0.0416666666666667 0.209163748990035 0.999980474973633 1 GO:0008236 serine-type peptidase activity 18/3713 194/18639 0.0927835051546392 0.465766698781934 0.999983960777233 1 GO:0099094 ligand-gated monoatomic cation channel activity 10/3713 136/18639 0.0735294117647059 0.369112498217709 0.999988018227003 1 GO:0015079 potassium ion transmembrane transporter activity 13/3713 160/18639 0.08125 0.407869310530568 0.999989263567048 1 GO:0017171 serine hydrolase activity 18/3713 198/18639 0.0909090909090909 0.456357270523713 0.999990697673053 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/3713 73/18639 0.0273972602739726 0.137532328103037 0.999998316865436 1 GO:0022824 transmitter-gated monoatomic ion channel activity 1/3713 63/18639 0.0158730158730159 0.07968142818668 0.999999186301125 1 GO:0022835 transmitter-gated channel activity 1/3713 63/18639 0.0158730158730159 0.07968142818668 0.999999186301125 1 GO:0005261 monoatomic cation channel activity 35/3713 341/18639 0.102639296187683 0.515242079623547 0.99999958181781 1 GO:0005216 monoatomic ion channel activity 50/3713 448/18639 0.111607142857143 0.560260041937594 0.999999810029739 1 GO:0022836 gated channel activity 28/3713 318/18639 0.0880503144654088 0.442006412960074 0.999999986248706 1 GO:0015276 ligand-gated monoatomic ion channel activity 11/3713 186/18639 0.0591397849462366 0.296877579211663 0.999999987544209 1 GO:0030594 neurotransmitter receptor activity 2/3713 97/18639 0.0206185567010309 0.10350371084043 0.999999989593425 1 GO:0022834 ligand-gated channel activity 11/3713 188/18639 0.0585106382978723 0.29371930709239 0.999999991146838 1 GO:0005549 odorant binding 1/3713 111/18639 0.00900900900900901 0.0452245943762238 0.999999999982 1 GO:0003823 antigen binding 5/3713 174/18639 0.028735632183908 0.144250861372438 0.999999999997835 1 GO:0004984 olfactory receptor activity 3/3713 419/18639 0.00715990453460621 0.0359422193968557 1 1 GO:0030371 translation repressor activity 8/3713 329/18639 0.0243161094224924 0.12206516658385 1 1 GO:0045182 translation regulator activity 14/3713 356/18639 0.0393258426966292 0.197412976574865 1 1