category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	71/1911	142/9376	2.45316588173731	UBE2M/UBE2F/HERC2/ANAPC5/UBE2E1/UBE2I/CUL3/FBXW7/UBE2G2/DDB1/HERC4/UBE2Q2/FBXW11/ANAPC16/CDC34/HUWE1/UBA3/UBE4A/WWP2/BIRC6/MDM2/ITCH/RHOBTB2/ANAPC7/SMURF2/PIAS4/RCHY1/CDC23/UBR5/CBL/CDC27/STUB1/ANAPC13/PML/KEAP1/CDC26/KLHL13/XIAP/SOCS1/WWP1/MGRN1/BTRC/ANAPC1/ANAPC10/TRIM32/PRPF19/SIAH1/CUL2/UBE2N/UBE2K/UBE2E2/UBE2G1/UBA2/UBE3B/ELOC/TRIP12/UBE2W/ANAPC11/SAE1/UBE2J1/PIAS3/ANAPC4/TRAF6/UBE2QL1/DET1/FZR1/CDC16/CUL5/SYVN1/NEDD4/UBE2H	8.82806466085215
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	94/1911	250/9376	1.84478074306646	SNF8/CHMP4A/RAB5C/ARF5/RAB35/EPS15L1/RAB4A/BIN1/AP2A1/VPS28/CHMP1B/AP2B1/RAB5A/ARF6/EHD2/ARFGEF2/MVB12A/ARPC5L/SNX2/ASAP2/ARF3/SNX1/PSD3/VPS36/VTA1/VPS4A/TGFBR2/ARFGAP3/AP2S1/STAMBP/RAB11FIP2/EHD4/EPN1/SPG21/MDM2/ITCH/RAB8A/GRK6/PARD3/SMURF2/DNM2/ARFGAP2/CBL/WASHC2A/WASHC4/HLA-F/PIP5K1C/PML/WIPF2/SH3GLB1/SMAP2/SH3KBP1/WWP1/SH3GL1/RAB11B/ACTR2/ACAP3/CXCR4/ZFYVE9/IGF2R/ASAP1/STAM2/CAV2/CHMP2A/VPS4B/SNX12/AP2M1/RAB11FIP3/HGS/SNX5/LDLR/SH3GLB2/HRAS/AP2A2/WASHC5/TRAF6/ACAP1/ARFGAP1/LDLRAP1/CXCR2/GRK4/CYTH3/ZFYVE27/RNF41/VPS37B/WASHC2C/GBF1/RAB22A/ARPC3/NEDD4/VPS29/EEA1/CAV1/CAPZB	6.84975208593339
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	80/1911	203/9376	1.93352975900478	COL6A2/HGF/RAP1A/AKT1/BCAR1/AKT2/ARHGAP5/GRB2/COL6A1/CTNNB1/PTEN/LAMB1/SOS2/DOCK1/PPP1CC/ACTN1/PPP1R12C/CRK/ZYX/PPP1R12B/DIAPH1/PPP1CA/PAK3/BAD/CCND3/PIP5K1C/ITGA5/MAPK1/COL1A1/PPP1R12A/ROCK1/EMP2/XIAP/PIK3CA/MAPK10/TNXB/VTN/LAMA2/ITGA4/TNC/CCND1/PRKCA/CRKL/COL4A4/COL4A5/ILK/ACTN4/LAMC1/FN1/ITGAV/CAV2/PAK2/FLNB/IGF1/CCND2/CAPN2/RAPGEF1/ARHGAP35/PARVB/LAMA4/FLNA/RAF1/HRAS/ITGA3/COL4A2/THBS3/VEGFC/PAK1/FLT1/ERBB2/COL1A2/PDGFRB/THBS2/MYLK/MYL5/SPP1/COL4A1/BRAF/VCL/CAV1	6.80333043247453
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	45/1911	103/9376	2.14354300345979	PPP2R2A/UPF3A/PPP2CB/GSPT1/CSTF3/PPP2R2D/PPP1CC/PNN/UPF2/MAGOHB/ETF1/PABPC4/TARDBP/PPP2R5C/ALYREF/CSTF1/SYMPK/PPP1CA/UPF3B/PCF11/WDR82/CPSF6/FUS/ACIN1/PPP2R5D/RNGTT/HBS1L/GSPT2/NUDT21/DDX39B/PPP2R1B/UPF1/SRRM1/CASC3/NCBP1/PYM1/MSI2/PELO/PABPN1/PPP2R3C/DDX19B/DAZAP1/CPSF2/SMG5/NXF1	5.904213578798
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	34/1911	70/9376	2.38307542797339	HGF/RAP1A/AKT1/TFE3/AKT2/GRB2/SOS2/EPAS1/CREBBP/CRK/MAP2K2/PAK3/BAD/PTPN11/CDKN1A/MAPK1/FH/PIK3CA/CRKL/CUL2/TGFB1/PAK2/HIF1A/KRAS/ELOC/RAPGEF1/RAF1/HRAS/ETS1/FLCN/PAK1/ARAF/TGFB2/BRAF	5.8764417722105
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	101/1911	308/9376	1.60889450685369	CREB3L1/HTT/UQCRC1/NDUFA11/NDUFA13/SDHA/MT-ND6/DCTN1/IFT57/SDHD/AP2A1/AP2B1/NDUFA9/PSMD13/PSMD11/HIP1/GNAQ/POLR2E/POLR2G/PSMD4/CREBBP/NDUFA2/PSMD14/NDUFS6/CREB3L2/NDUFB5/PSMB4/VDAC3/AP2S1/ATG14/ATP5F1C/NDUFB10/ATP5MC1/ACTR1B/SP1/NDUFB6/PSMC2/PSMC1/PSMC4/ATP5PB/TFAM/ACTR1A/NDUFB7/SDHB/NDUFV1/ACTR10/BAX/NDUFS1/NDUFS7/POLR2I/PSMB6/UQCRFS1/ATP5MC2/POLR2B/UQCR11/TUBA1C/PSMC5/CREB1/MAPK10/UQCRH/SLC25A6/DNAH14/POLR2D/PSMA6/MAP2K7/NDUFS8/CREB3/NDUFB1/ATP5F1D/PSMB3/DCTN3/UQCRQ/KLC1/AP2M1/NDUFA3/PSMD12/PSMD2/NDUFS2/GPX3/CREB5/DCTN2/COX6B1/MT-ATP8/PSMB7/TUBA4A/AP2A2/PSMB5/ITPR1/DNAL1/ATP5F1B/PIK3R4/GRIA3/DLG4/TAF4/NDUFA1/REST/TUBB6/NDUFV2/COX7A1/ATG13/ATG2B	5.49746830670019
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	144/1911	480/9376	1.47189952904239	PPP3CA/HTT/UQCRC1/NDUFA11/WDR41/NDUFA13/SDHA/VAPB/MT-ND6/WNT2/DCTN1/ITPR2/UBE2G2/IFT57/SDHD/CTNNB1/NDUFA9/RAB5A/PSMD13/PSMD11/CSNK1E/HIP1/ATXN3/HTRA2/GNAQ/PSMD4/NDUFA2/PSMD14/EIF2S1/NDUFS6/MAP2K2/NDUFB5/PSMB4/VDAC3/DVL3/ATXN1/CAPN1/ATG14/TARDBP/APC/PPP3CB/RAB8A/ALS2/CACNA1C/BID/ATP5F1C/NDUFB10/ATP5MC1/ACTR1B/NDUFB6/ATXN2/CSNK2A1/PSMC2/PSMC1/BAD/PSMC4/ATP5PB/ACTR1A/NDUFB7/FUS/PRNP/SDHB/NDUFV1/ACTR10/BAX/NDUFS1/NDUFS7/MAP1LC3A/PPP3R1/MAP2K3/MAPK1/PSMB6/UQCRFS1/ATP5MC2/VCP/UQCR11/TUBA1C/PSMC5/MAPK10/UQCRH/SLC25A6/DNAH14/CDK5/C9orf72/PSMA6/PRKCA/MAP2K7/NDUFS8/MFN2/RELA/NDUFB1/ATP5F1D/CSNK2A2/PSMB3/DCTN3/UQCRQ/FADD/WNT5B/KRAS/KLC1/UBE2G1/TOMM40/NDUFA3/HSD17B10/UCHL1/CAPN2/PSMD12/PSMD2/NDUFS2/GPX3/ZFYVE1/TANK/CAT/DCTN2/COX6B1/MT-ATP8/PSMB7/TUBA4A/RAF1/HRAS/UBE2J1/CALM3/PSMB5/ITPR1/CAMK2D/CYBB/DDIT3/DNAL1/ATXN1L/ATP5F1B/PIK3R4/FZD1/GRIA3/DLG4/NDUFA1/FAS/CSF1/ARAF/TUBB6/NDUFV2/COX7A1/BRAF/ATG13/ATG2B	5.36999462723456
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	45/1911	108/9376	2.04430490144776	TNPO1/UBE2I/UPF3A/THOC7/THOC2/TNPO2/NUP62/KPNB1/PNN/UPF2/MAGOHB/PHAX/IPO5/ALYREF/UPF3B/XPOT/NUP50/SUMO3/SNUPN/KPNA4/ACIN1/SUMO1/IPO13/RANBP17/XPO5/NUP160/THOC6/IPO9/NUP37/POM121/DDX39B/UPF1/SRRM1/CASC3/NCBP1/PYM1/NUP88/IPO7/SENP2/THOC3/DDX19B/RAE1/POM121C/TPR/NXF1	5.52264665217549
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	119/1911	388/9376	1.50477700993165	APH1A/SLC39A9/PPP3CA/UQCRC1/NDUFA11/NDUFA13/ADAM17/SDHA/AKT1/MT-ND6/WNT2/AKT2/ITPR2/BACE1/SDHD/CTNNB1/NDUFA9/PSMD13/PSMD11/CSNK1E/SLC39A13/GNAQ/PSMD4/NDUFA2/PSMD14/EIF2S1/NDUFS6/MAP2K2/NDUFB5/PSMB4/VDAC3/DVL3/CAPN1/ATG14/APC/PPP3CB/PSENEN/CACNA1C/BID/ATP5F1C/NDUFB10/ATP5MC1/NDUFB6/CSNK2A1/PSMC2/PSMC1/BAD/PSMC4/ATP5PB/NDUFB7/SDHB/NDUFV1/NDUFS1/NDUFS7/PPP3R1/APH1B/MAPK1/PSMB6/UQCRFS1/ATP5MC2/NCSTN/NAE1/UQCR11/TUBA1C/PSMC5/PIK3CA/MAPK10/UQCRH/SLC25A6/CDK5/PSMA6/MAP2K7/NDUFS8/RELA/NDUFB1/ATP5F1D/CSNK2A2/PSMB3/UQCRQ/FADD/WNT5B/KRAS/KLC1/NDUFA3/LRP1/HSD17B10/CAPN2/PSMD12/PSMD2/NDUFS2/COX6B1/MT-ATP8/PSMB7/TUBA4A/RAF1/HRAS/CALM3/APOE/PSMB5/ITPR1/CYBB/APBB1/DDIT3/ATP5F1B/PIK3R4/FZD1/NDUFA1/FAS/CSF1/ARAF/TUBB6/NDUFV2/COX7A1/BRAF/SLC39A4/ATG13/IDE/SLC11A2/ATG2B	5.13789202764322
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	89/1911	275/9376	1.58786737072451	CREB3L1/PPP3CA/PRKACA/UQCRC1/NDUFA11/NDUFA13/SDHA/MT-ND6/ITPR2/SDHD/NDUFA9/PSMD13/PSMD11/PSMD4/NDUFA2/PSMD14/EIF2S1/NDUFS6/CREB3L2/NDUFB5/PSMB4/VDAC3/PPP3CB/CACNA1C/ATP5F1C/NDUFB10/ATP5MC1/NDUFB6/CSNK2A1/PSMC2/PSMC1/BAD/PSMC4/ATP5PB/NDUFB7/PRNP/SDHB/NDUFV1/BAX/NDUFS1/NDUFS7/PPP3R1/MAPK1/PSMB6/UQCRFS1/ATP5MC2/UQCR11/TUBA1C/PSMC5/CREB1/PIK3CA/MAPK10/STIP1/UQCRH/SLC25A6/PSMA6/NDUFS8/CREB3/NDUFB1/ATP5F1D/CSNK2A2/LAMC1/PSMB3/CAV2/UQCRQ/ATF6B/KLC1/NDUFA3/PSMD12/PSMD2/NDUFS2/CREB5/COX6B1/MT-ATP8/PSMB7/TUBA4A/PSMB5/ITPR1/CYBB/DDIT3/ATP5F1B/NCF2/NCF1/NDUFA1/TUBB6/NDUFV2/COX7A1/CAV1/CYBA	5.00613112672628
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	34/1911	77/9376	2.16643220724853	AKT1/AKT2/GRB2/MYC/SOS2/CRK/TGFBR2/MAP2K2/MDM2/CBL/CDK4/BAD/PTPN11/ABL1/CDKN1B/BAX/CDKN1A/MAPK1/RB1/CDK6/PIK3CA/CDKN2A/CCND1/SMAD4/CRKL/RELA/TGFB1/KRAS/CTBP1/RAF1/HRAS/ARAF/TGFB2/BRAF	5.19981409848013
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	75/1911	224/9376	1.64274501009195	CREB3L1/PPP3CA/PRKACA/ANAPC5/AKT1/NFKB2/AKT2/MYC/PTEN/NRP1/ANAPC16/CREBBP/ADCY3/TGFBR2/CREB3L2/MAP2K2/VDAC3/PPP3CB/ANAPC7/CDC23/CRTC3/BUB3/CDK4/LTBR/HLA-F/CCND3/CDC27/BAX/ANAPC13/PPP3R1/DLG1/CDKN1A/RELB/MAPK1/CDC26/RANBP1/RB1/XIAP/ELK4/CREB1/PIK3CA/MAPK10/ATM/NFATC4/MAP2K4/FDPS/SLC25A6/CDKN2A/CRTC2/ANAPC1/ANAPC10/CCND1/GPS2/SMAD4/CREB3/RELA/IL15/TGFB1/TSPO/ATF6B/KRAS/CCND2/CREB5/ANAPC11/HRAS/ETS1/ANAPC4/ADCY9/MAD1L1/MAP3K3/CDC16/NFYB/JAK1/TGFB2/HLA-DPA1	4.92612914039263
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	57/1911	158/9376	1.77000576277249	ANAPC5/MYC/PPP2CB/SMC3/TFDP2/ANAPC16/NIPBL/CREBBP/RAD21/STAG2/WAPL/MDM2/PPP2R5C/CDC14B/ANAPC7/CDC23/ESCO1/BUB3/CDK4/ATRX/CCND3/ABL1/CDKN1B/CDC27/YWHAG/ANAPC13/STAG1/CDKN1A/CDC26/ORC3/RB1/YWHAH/CDK6/ATM/PPP2R5D/CDKN2A/MAU2/ANAPC1/ANAPC10/CCND1/SMAD4/TGFB1/PPP2R1B/CCND2/WEE1/ANAPC11/CCNH/ANAPC4/DBF4/ORC5/CDC14A/MCM3/MAD1L1/FZR1/CDC16/TGFB2/CDK7	4.93861581420895
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	75/1911	227/9376	1.62103472361496	HGF/UQCRC1/NDUFA11/NDUFA13/SDHA/AKT1/MT-ND6/AKT2/GRB2/SDHD/PTEN/FOXO3/NDUFA9/SOS2/SLC26A6/NDUFA2/AKR1A1/NDUFS6/MAP2K2/NDUFB5/VDAC3/ATP5F1C/NDUFB10/ATP5MC1/NDUFB6/ACP1/BAD/ATP5PB/PTPN11/ABL1/NDUFB7/CBR1/SDHB/NDUFV1/NDUFS1/NDUFS7/KEAP1/MAPK1/UQCRFS1/ATP5MC2/UQCR11/GSTM5/PIK3CA/MAPK10/MAP2K4/UQCRH/SLC25A6/MAP2K7/NDUFS8/RELA/NDUFB1/ATP5F1D/GSTA4/UQCRQ/HIF1A/KRAS/NDUFA3/NDUFS2/EPHX1/CAT/COX6B1/MT-ATP8/RAF1/HRAS/ATP5F1B/GSTM2/NCF2/NCF1/PTPRJ/NDUFA1/ARAF/NDUFV2/COX7A1/BRAF/CYBA	4.79228981058312
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	77/1911	235/9376	1.60760657781934	CREB3L1/PRKACA/UQCRC1/NDUFA11/NDUFA13/SDHA/MT-ND6/PNPLA2/GRB2/SDHD/NDUFA9/COA3/KDM1A/SOS2/PRKAG2/RPS6KB1/NDUFA2/ADCY3/NDUFS6/CREB3L2/NDUFB5/ARID1A/SMARCC2/PRKAB2/TSC1/ATP5F1C/NDUFB10/ATP5MC1/NDUFAF2/FGFR1/NDUFB6/ATP5PB/NDUFB7/SDHB/NDUFV1/NDUFS1/NDUFS7/NDUFAF7/MAP2K3/UQCRFS1/ATP5MC2/UQCR11/CREB1/UQCRH/COX15/COX16/NDUFAF4/SMARCB1/NDUFS8/CREB3/COA4/NDUFB1/ATP5F1D/ACSL3/UQCRQ/RPS6KA3/KRAS/NDUFA3/ARID1B/NDUFS2/CREB5/COX6B1/MT-ATP8/HRAS/RPS6KB2/ADCY9/ATP5F1B/CPT2/SLC25A29/COX10/CNR1/NDUFA1/COA1/NDUFAF3/SMARCC1/NDUFV2/COX7A1	4.7726613455142
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	101/1911	333/9376	1.48810663096377	CREB3L1/COL6A2/PRKACA/UBR4/RFNG/AKT1/WNT2/AKT2/GRB2/ATP6V0D1/PPP2R2A/COL6A1/CTNNB1/PTEN/PPP2CB/LAMB1/SOS2/PPP2R2D/RPS6KB1/ATP6V1A/CREBBP/CREB3L2/MAP2K2/DVL3/APC/MDM2/PPP2R5C/TSC1/PARD3/TADA3/CDK4/PSMC1/BAD/HLA-F/CCND3/MAML2/CDKN1B/BCAP31/BAX/DLG1/CDKN1A/ITGA5/MAPK1/IFNAR1/COL1A1/ATP6V1C1/RB1/CDK6/CREB1/PIK3CA/TNXB/ATM/VTN/LAMA2/PPP2R5D/ITGA4/MAGI1/TNC/CCND1/IRF3/COL4A4/COL4A5/CREB3/RELA/LAMC1/FN1/ITGAV/CHD4/NFX1/FADD/PPP2R1B/WNT5B/KRAS/CCND2/ATP6V1H/NOTCH2/HES1/CREB5/LAMA4/RAF1/HRAS/LFNG/RPS6KB2/PPP2R3C/ITGA3/NOTCH3/COL4A2/THBS3/FZD1/SCRIB/COL1A2/PDGFRB/THBS2/FAS/TRADD/EIF4EBP1/TYK2/SPP1/COL4A1/JAK1/ATP6V1E1	4.58861514972014
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	68/1911	204/9376	1.63544392115821	PRKACA/HGF/AKT1/WNT2/AKT2/GRB2/ITPR2/MYC/CTNNB1/GPC1/SOS2/SDC4/RPS6KB1/PPP1CC/PLCG2/PLAU/PPP1R12C/HSPG2/MAP2K2/GPC3/MDM2/PPP1R12B/PPP1CA/ESR1/CBL/FGFR1/PTPN11/PDCD4/CDKN1A/ITGA5/MAPK1/COL1A1/PPP1R12A/ROCK1/SLC9A1/PIK3CA/VTN/CCND1/PRKCA/NUDT16L1/RDX/FN1/TGFB1/ITGAV/CAV2/HIF1A/WNT5B/KRAS/IGF1/FLNA/RAF1/HRAS/ITPR1/CAMK2D/RPS6KB2/HCLS1/FZD1/PAK1/PTPN6/ERBB2/COL1A2/FAS/ARAF/STAT3/TGFB2/BRAF/CAV1/SDC2	4.64260105598261
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	17/1911	30/9376	2.78025466596895	IDH3G/SDHA/SDHD/DLD/DLAT/IDH2/OGDH/ACO1/ACLY/SDHB/FH/ACO2/PDHA1/IDH3B/IDH1/PC/SUCLG1	4.94118310069298
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/1911	73/9376	2.08351074887278	HGF/AKT1/AKT2/GRB2/FOXO3/SOS2/PLCG2/MAP2K2/CDK4/BAD/BAX/CDKN1A/MAPK1/RB1/CDK6/PIK3CA/CDKN2A/CCND1/PRKCA/EML4/STK4/KRAS/RASSF1/RAF1/HRAS/RXRB/ERBB2/ARAF/RXRA/STAT3/BRAF	4.70201726380127
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	45/1911	122/9376	1.80971253570785	CREB3L1/AKT1/AKT2/PPP2R2A/PPP2CB/FOXO3/PFKL/PRKAG2/CAMKK2/STK11/PPP2R2D/RPS6KB1/CREB3L2/PPP2R5C/RAB8A/PRKAB2/TSC1/CREB1/PIK3CA/SREBF1/G6PC3/RAB11B/PPP2R5D/CRTC2/CCND1/CD36/CREB3/ELAVL1/PPP2R1B/IGF1/TBC1D1/CREB5/STRADB/HMGCR/RPS6KB2/PFKM/PPP2R3C/ACACA/FASN/EEF2K/MLYCD/EIF4EBP1/MAP3K7/PFKFB3/ACACB	4.55456711783774
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	108/1911	368/9376	1.43990171319364	PPP3CA/UQCRC1/NDUFA11/WDR41/NDUFA13/SDHA/VAPB/MT-ND6/DCTN1/SDHD/ANXA11/NDUFA9/RAB5A/PSMD13/PSMD11/NUP62/PSMD4/NDUFA2/PSMD14/EIF2S1/NDUFS6/NDUFB5/PSMB4/ATG14/TARDBP/PPP3CB/RAB8A/ALS2/ALYREF/BID/ATP5F1C/NDUFB10/ATP5MC1/ACTR1B/NDUFB6/ATXN2/PSMC2/PSMC1/BAD/PSMC4/ATP5PB/CHCHD10/ACTR1A/NDUFB7/FUS/SDHB/NDUFV1/ACTR10/BAX/NUP50/NDUFS1/NDUFS7/MAP1LC3A/PPP3R1/MAP2K3/PSMB6/UQCRFS1/ATP5MC2/VCP/UQCR11/TUBA1C/PSMC5/UQCRH/DNAH14/C9orf72/NUP160/PSMA6/NUP37/NDUFS8/NDUFB1/ATP5F1D/PSMB3/DCTN3/UQCRQ/HNRNPA1/POM121/KLC1/TOMM40/NDUFA3/PSMD12/PSMD2/NDUFS2/GPX3/NCBP1/NUP88/TANK/CAT/DCTN2/COX6B1/MT-ATP8/PSMB7/TUBA4A/PSMB5/DDIT3/DNAL1/ATP5F1B/PIK3R4/RAE1/NDUFA1/POM121C/TUBB6/TPR/NDUFV2/COX7A1/UBQLN2/ATG13/NXF1/ATG2B	4.35578514668255
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	78/1911	250/9376	1.53077551020408	AP1M1/LAPTM4B/TFE3/ATP6V0D1/LGMN/AP2A1/AP2B1/DMXL1/MANBA/ATP6V1A/GUSB/AP2S1/HGSNAT/AP1G1/IDUA/AP3S2/TELO2/CTSS/SNAP29/HYAL2/NAGLU/KXD1/ATP6V1C1/GALNS/HEXA/AGA/TPCN1/VPS33A/AP1G2/NAGA/TTI1/LAMTOR4/IGF2R/VPS13A/AP1S2/AP3B1/CTSZ/GLB1/VAMP7/LIPA/MCOLN1/AP2M1/GNPTAB/SCARB2/GALC/AP3D1/ATP6V1H/CTSC/SORT1/ENTPD4/SLC15A4/HEXB/AP2A2/GPR155/TFEB/BORCS5/PLA2G15/GGA3/OSBPL2/GGA1/PIKFYVE/TMEM175/SLC36A1/NAGPA/ARL8A/LAMTOR3/VPS16/ACP5/BLOC1S1/CTSA/ATP6V1E1/GM2A/SLC11A2/CLCN7/GGA2/VPS29/GAA/LAMTOR1	4.30369736528991
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	77/1911	248/9376	1.52333687817559	STX10/EXOC4/PTPRC/RAB5C/EXOC7/TXN2/AKT1/DCTN1/AKT2/MYC/CTNNB1/RAB5A/ARF6/PKN1/GCC2/ARPC5L/EXOC5/MAP2K2/CYFIP1/DNM2/ACTR1B/PAK3/ACTR1A/DYNLL2/ACTR10/BAX/ACBD3/DYNC1LI2/PLEKHM2/PIK3C2A/MAP2K3/MAPK1/TUBA1C/NCKAP1/KPNA4/PIK3CA/MAPK10/MAP2K4/ACTR2/VPS33A/GSDMD/MAP2K7/RELA/DCTN3/TAB2/RHOG/FADD/KLC1/CASP4/DYNLRB1/DCTN2/FLNA/TUBA4A/RAF1/MYO6/HRAS/TRAF6/DYNC2H1/WASF3/TAB1/RAB7B/CYTH3/PAK1/ARL8A/DYNLT3/TRADD/MYL5/VPS16/DYNC1I2/TUBB6/AHNAK/ARPC3/BRK1/MAP3K7/PYCARD/RILP/PODXL	4.22591190962509
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	33/1911	83/9376	1.9507102192128	PCGF5/CBX4/USP16/MAX/LCOR/EZH1/PCGF2/CREBBP/CBX6/RBBP7/SUZ12/AUTS2/SFMBT2/YAF2/KDM2A/FBRS/PHC3/JARID2/ASXL1/BAP1/FOXK1/SCMH1/PHF1/BMI1/ASXL2/E2F6/MBD5/BCORL1/MGA/CBX7/L3MBTL2/CBX3/PCGF3	4.40159738965396
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	66/1911	205/9376	1.57959949458207	UQCRC1/NDUFA11/NDUFA13/SDHA/AKT1/MT-ND6/PDK2/G6PD/AKT2/SDHD/PTEN/NDUFA9/PPP1CC/NDUFA2/TGFBR2/NDUFS6/NDUFB5/VDAC3/ATP5F1C/NDUFB10/ATP5MC1/PPP1CA/SP1/NDUFB6/ATP5PB/NDUFB7/SDHB/NDUFV1/NDUFS1/NDUFS7/UQCRFS1/COL1A1/ATP5MC2/UQCR11/PIK3CA/MAPK10/UQCRH/SLC25A6/GFPT2/PRKCA/CD36/NDUFS8/PDHA1/RELA/NDUFB1/ATP5F1D/TGFB1/UQCRQ/NDUFA3/NDUFS2/COL3A1/COX6B1/MT-ATP8/CAMK2D/CYBB/ATP5F1B/CPT2/NCF2/NCF1/COL1A2/NDUFA1/GFPT1/NDUFV2/COX7A1/TGFB2/CYBA	4.24519513241148
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	42/1911	116/9376	1.77643046608564	ECHS1/GCSH/IDH3G/TKT/SDHA/G6PD/SDHD/PFKL/PGD/ACAT2/DLD/DLAT/IDH2/OGDH/ALDOA/ACO1/ACAT1/PGLS/RPE/SDHB/GPI/FH/HK1/ACO2/ME2/ESD/PCCB/SHMT2/GOT2/PDHA1/IDH3B/IDH1/TALDO1/CAT/PGP/PRPS1/PFKM/MCEE/PC/SDSL/SUCLG1/ACADS	4.25723030641943
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	33/1911	86/9376	1.88266218831003	AKT1/AKT2/GRB2/MYC/SOS2/RPS6KB1/PLCG2/CRK/MAP2K2/PAK3/CBL/BAD/ABL1/CDKN1B/CDKN1A/MAPK1/PIK3CA/MAPK10/MAP2K4/PRKCA/MAP2K7/CRKL/PAK2/KRAS/RAF1/HRAS/CAMK2D/RPS6KB2/PAK1/ERBB2/ARAF/EIF4EBP1/BRAF	4.16041800211331
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	47/1911	138/9376	1.67099704987904	FLOT1/PRKACA/EXOC7/AKT1/INPP5A/AKT2/GRB2/SOS2/PRKAG2/FLOT2/RPS6KB1/PPP1CC/CRK/MAP2K2/PRKAB2/TSC1/PPP1CA/CBL/BAD/MAPK1/HK1/SOCS1/PIK3CA/MAPK10/SREBF1/G6PC3/TRIP10/CRKL/KRAS/SOCS4/PHKB/RAPGEF1/RAF1/HRAS/CALM3/PYGM/RPS6KB2/ACACA/FASN/PYGL/MKNK1/ARAF/EIF4EBP1/PHKG1/BRAF/ACACB/MKNK2	4.01765139182589
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	80/1911	268/9376	1.46457664581332	SLC39A9/PRKACA/UQCRC1/NDUFA11/NDUFA13/TXN2/SDHA/MT-ND6/ITPR2/UBE2G2/SDHD/NDUFA9/PSMD13/PSMD11/HTRA2/SLC39A13/PSMD4/NDUFA2/PSMD14/EIF2S1/NDUFS6/NDUFB5/PSMB4/VDAC3/ATP5F1C/NDUFB10/ATP5MC1/NDUFB6/PSMC2/PSMC1/PSMC4/ATP5PB/NDUFB7/SDHB/NDUFV1/BAX/NDUFS1/NDUFS7/KEAP1/PSMB6/UQCRFS1/ATP5MC2/UQCR11/TUBA1C/PSMC5/MAPK10/UQCRH/SLC25A6/PSMA6/NDUFS8/MFN2/NDUFB1/ATP5F1D/PSMB3/UQCRQ/KLC1/UBE2G1/NDUFA3/GNAI3/UCHL1/PSMD12/PSMD2/NDUFS2/COX6B1/MT-ATP8/PSMB7/TUBA4A/UBE2J1/CALM3/PSMB5/ITPR1/CAMK2D/DDIT3/ATP5F1B/NDUFA1/TUBB6/NDUFV2/COX7A1/SLC39A4/SLC11A2	3.90404069339301
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	25/1911	62/9376	1.97835958204622	NUMB/APH1A/RFNG/ADAM17/NUMBL/SPEN/CREBBP/NCOR2/DVL3/ATXN1/ITCH/PSENEN/DTX1/CIR1/MAML2/APH1B/NCSTN/TLE4/NOTCH2/HES1/CTBP1/LFNG/TLE1/ATXN1L/NOTCH3	3.91045512541988
NA	NA	hsa04518	Integrin signaling	50/1911	154/9376	1.59296485827098	COL6A2/HGF/AKT1/AKT2/COL6A1/CTNNB1/LAMB1/ACTN1/LIMS2/CCND3/ITGA5/COL1A1/VCAM1/PIK3CA/TNXB/VTN/LAMA2/FERMT3/ITGA4/TNC/CCND1/COL4A4/COL4A5/ILK/ACTN4/LAMC1/FN1/TGFB1/ITGAV/FLNB/IGF1/CCND2/PARVB/LAMA4/FLNA/ITGAX/ITGA3/COL4A2/THBS3/FGB/VEGFC/FLT1/ERBB2/COL1A2/PDGFRB/THBS2/SPP1/COL4A1/VCL/ITGAE	3.75385793836072
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	16/1911	33/9376	2.37882752168466	STX16/VAMP5/GOSR1/SNAP29/VTI1B/BET1/BNIP1/STX2/SNAP23/SEC22B/VAMP7/BET1L/GOSR2/YKT6/VTI1A/STX6	4.01443855178386
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/1911	59/9376	1.9957959715829	AKT1/AKT2/GRB2/MYC/CTNNB1/PTEN/FOXO3/SOS2/MAP2K2/APC/BAD/BAX/CDKN1A/MAPK1/PIK3CA/CCND1/ILK/KRAS/RAF1/HRAS/ERBB2/ARAF/MLH1/BRAF	3.8820345726387
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	52/1911	163/9376	1.56521013313301	CREB3L1/STAT6/AKT1/AKT2/GRB2/MYC/DDB1/SOS2/CREBBP/HSPG2/TGFBR2/CREB3L2/MAP2K2/VDAC3/BID/BAD/BAX/CDKN1A/MAP2K3/MAPK1/IFNAR1/RB1/CREB1/PIK3CA/MAPK10/NFATC4/MAP2K4/PRKCA/SMAD4/MAP2K7/IRF3/CREB3/RELA/TGFB1/ATF6B/TAB2/FADD/KRAS/CREB5/MAVS/RAF1/HRAS/TRAF6/TAB1/FAS/ARAF/TYK2/STAT3/JAK1/TGFB2/MAP3K7/BRAF	3.68302173347901
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	25/1911	63/9376	1.94695704899787	ECHS1/KMT5A/ALDH7A1/KMT2E/KMT2A/ALDH9A1/KMT2C/EZH1/PLOD1/NSD3/ACAT2/DLD/EHMT1/ACAT1/SETD2/KMT5B/COLGALT1/KMT2B/SETD7/SETDB2/PLOD3/SMYD3/PLOD2/PHYKPL/SETDB1	3.81554719844153
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	50/1911	157/9376	1.56252603932313	PPP3CA/AKT1/AKT2/NBN/ITPR2/MYC/PTEN/FOXO3/FBXW11/HIPK3/PPP1CC/TGFBR2/MAP2K2/VDAC3/CAPN1/PPP3CB/MDM2/TSC1/PPP1CA/CDK4/HLA-F/CCND3/PPP3R1/CDKN1A/MAP2K3/MAPK1/RB1/CDK6/PIK3CA/HUS1/ATM/NFATC4/SLC25A6/HIPK1/CDKN2A/BTRC/CCND1/RELA/TGFB1/KRAS/CCND2/CAPN2/RAF1/HIPK2/HRAS/ETS1/CALM3/ITPR1/EIF4EBP1/TGFB2	3.59626449327283
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	15/1911	31/9376	2.37403149845546	TKT/G6PD/PFKL/PGD/DERA/ALDOA/PGLS/RPE/GPI/TALDO1/PRPS1/PFKM/RBKS/SHPK/PGM1	3.87693891578434
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	27/1911	71/9376	1.86578813540584	AKT1/G6PD/AKT2/MYC/PTEN/PFKL/GLS/MAP2K2/TIGAR/IDH2/FGFR1/SLC1A5/MAPK1/LDHB/HK1/PIK3CA/PDHA1/HIF1A/KRAS/IDH1/SLC16A3/RAF1/HRAS/PFKM/NTRK1/ERBB2/PDGFRB	3.70496143151799
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	53/1911	169/9376	1.53867209150387	PRKACA/WDR41/EIF2AK4/AKT1/AKT2/PTEN/PPP2CB/CAMKK2/STK11/RPS6KB1/EIF2S1/MAP2K2/ATG14/DAPK3/BIRC6/RAB8A/TSC1/ATG4B/ATG4A/SNAP29/BAD/GORASP2/WDR45B/MAP1LC3A/UVRAG/MAPK1/SH3GLB1/PIK3CA/WDFY3/MAPK10/C9orf72/VPS33A/HIF1A/KRAS/NBR1/ZFYVE1/TANK/RAF1/HRAS/YKT6/ITPR1/ATG7/TRAF6/RPS6KB2/RAB7B/GORASP1/PIK3R4/VPS16/CFLAR/MAP3K7/ATG13/ATG2B/DDIT4	3.57527812603299
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	18/1911	41/9376	2.15399931079374	MYC/MAP2K2/DAPK3/MDM2/CDK4/CDKN1A/MAPK1/RB1/CDKN2A/CCND1/KRAS/TYMP/RASSF1/RAF1/HRAS/ERBB2/ARAF/BRAF	3.7466350560717
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	32/1911	90/9376	1.74447351590209	CREB3L1/PRKACA/AKT1/AKT2/FOXO3/PRKAG2/CAMKK2/STK11/RPS6KB1/ADCY3/CREB3L2/SESN1/EHMT1/PRKAB2/TSC1/BAX/APPL1/CREB1/PIK3CA/CREB3/RELA/SESN3/ATF6B/KRAS/IGF1/CREB5/CAT/HRAS/RPS6KB2/ADCY9/EIF4EBP1/ATG13	3.59051911720045
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	67/1911	227/9376	1.44812435309603	CREB3L1/PPP3CA/PRKACA/AKT1/BCAR1/AKT2/GRB2/ITPR2/MYC/CTNNB1/SOS2/RPS6KB1/GNAQ/GNB1/ADCY3/CRK/CREB3L2/MAP2K2/PPP3CB/MDM2/TSC1/BID/SP1/CCL2/CDK4/HLA-F/GNA11/BAX/PPP3R1/CDKN1A/MAPK1/ROCK1/RB1/CDK6/CREB1/PIK3CA/NFATC4/CXCR4/CDKN2A/CCND1/PRKCA/IRF3/CRKL/CREB3/RELA/GNB2/ITGAV/ATF6B/FADD/KRAS/GNAI3/CREB5/RAF1/HRAS/CALM3/ITPR1/RPS6KB2/ADCY9/CXCR2/CXCL12/FAS/TRADD/EIF4EBP1/TAPBPL/STAT3/JAK1/CGAS	3.45800595289698
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	29/1911	80/9376	1.77854526425955	HGF/AKT1/AKT2/GRB2/PTEN/FOXO3/SOS2/RPS6KB1/PLCG2/MAP2K2/BAD/GAS6/NF1/BAX/MAPK1/PIK3CA/PRKCA/KRAS/IGF1/RAF1/HRAS/RPS6KB2/ERBB2/PDGFRB/ARAF/EIF4EBP1/STAT3/JAK1/BRAF	3.53819593322527
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	27/1911	73/9376	1.81467065224404	CHMP4A/SUPT4H1/APOBEC3C/PIN1/CREBBP/VPS4A/CDK9/MAP1S/CPSF6/MLLT1/CCNT2/SERINC5/PSIP1/CXCR4/SMARCB1/AFF4/MAP1A/VPS4B/SUPT5H/NELFE/HGS/MLLT3/FURIN/ELL/NELFB/APOBEC3A/MDFIC	3.53535530233439
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/1911	99/9376	1.68500282785997	PRKACA/AKT1/AKT2/GRB2/SOS2/RPS6KB1/ADCY3/MAP2K2/MDM2/ESR1/SP1/CDK4/BAD/CDKN1B/BAX/CDKN1A/MAPK1/RB1/PIK3CA/MAPK10/CDKN2A/CCND1/KRAS/IGF1/NCOR1/NOTCH2/RAF1/HRAS/RPS6KB2/ADCY9/NOTCH3/ERBB2/ARAF/BRAF	3.46662814822225
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	28/1911	77/9376	1.7841206412635	AKT1/AKT2/RPS6KB1/TGFBR2/CDK4/BAD/BAX/CDKN1A/MAPK1/RB1/CDK6/PIK3CA/MAPK10/CDKN2A/CCND1/SMAD4/RELA/TGFB1/KRAS/RAF1/RPS6KB2/RALGDS/ERBB2/ARAF/STAT3/JAK1/TGFB2/BRAF	3.49551524727614
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	44/1911	138/9376	1.56433766371655	UQCRC1/NDUFA11/NDUFA13/SDHA/MT-ND6/ATP6V0D1/SDHD/NDUFA9/ATP6V1A/NDUFA2/NDUFS6/NDUFB5/ATP5F1C/NDUFB10/ATP5MC1/NDUFB6/ATP5PB/NDUFB7/SDHB/NDUFV1/NDUFS1/NDUFS7/LHPP/UQCRFS1/ATP5MC2/ATP6V1C1/UQCR11/UQCRH/COX15/NDUFS8/NDUFB1/ATP5F1D/UQCRQ/NDUFA3/ATP6V1H/NDUFS2/COX6B1/MT-ATP8/ATP5F1B/COX10/NDUFA1/NDUFV2/COX7A1/ATP6V1E1	3.37901932728212
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	63/1911	214/9376	1.44438738831262	PPP3CA/AP1M1/AKT1/APOBEC3C/AKT2/ITPR2/DDB1/FBXW11/RPS6KB1/GNAQ/PLCG2/GNB1/CRK/MAP2K2/PPP3CB/AP1G1/BID/PAK3/BAD/HLA-F/GNA11/BAX/PPP3R1/MAP2K3/MAPK1/PIK3CA/MAPK10/ATM/NFATC4/CXCR4/BTRC/AP1G2/PRKCA/MAP2K7/IRF3/CRKL/RELA/GNB2/AP1S2/PAK2/TAB2/FADD/KRAS/GNAI3/ELOC/CFL2/WEE1/RAF1/HRAS/CALM3/ITPR1/TRAF6/RPS6KB2/TAB1/PAK1/APOBEC3A/FAS/TRADD/CUL5/TAPBPL/CGAS/MAP3K7/LIMK2	3.32716657059156
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/1911	46/9376	2.02652833708734	PSMD13/PSMD11/PSMD4/PSMD14/PSMB4/PSMC2/PSMC1/PSMC4/PSMB6/PSMC5/PSMB9/PSMF1/PSMA6/PSMB3/PSME3/PSMD12/PSMD2/PSMB7/PSMB5	3.5311007746482
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	53/1911	174/9376	1.49445737623078	PRKCSH/MAN1A2/UBE2G2/CKAP4/ATXN3/MAN1B1/RAD23A/BAG2/MBTPS1/TUSC3/EIF2S1/CAPN1/NSFL1C/DNAJB2/KRTCAP2/SEC24D/BCAP31/BAX/STUB1/DNAJA2/DNAJC5/MAN1A1/VCP/UGGT1/MAPK10/SEC24B/NPLOC4/TXNDC5/MBTPS2/MAP2K7/RNF185/ATF6B/UBE2G1/DNAJB12/EDEM3/SAR1A/CAPN2/UBXN6/RPN1/DERL2/NGLY1/SIL1/RAD23B/WFS1/UBE2J1/UGGT2/DDIT3/HSPBP1/SEC23A/MOGS/UBQLN2/SYVN1/SEC24C	3.33091419542897
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	25/1911	68/9376	1.8037984424539	AKT1/AKT2/GRB2/MYC/SOS2/RPS6KB1/MAP2K2/RUNX1T1/DUSP6/BAD/PML/MAPK1/PIK3CA/CCND1/RELA/KRAS/RAF1/HRAS/ZBTB16/RPS6KB2/ARAF/EIF4EBP1/PIM1/STAT3/BRAF	3.36569304309029
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	30/1911	87/9376	1.69183853912918	AKT1/MSH3/AKT2/GRB2/MYC/CTNNB1/SOS2/RPS6KB1/TGFBR2/MAP2K2/APC/BAD/BAX/CDKN1A/MAPK1/APPL1/PIK3CA/MAPK10/CCND1/SMAD4/TGFB1/KRAS/RAF1/HRAS/RPS6KB2/RALGDS/ARAF/TGFB2/MLH1/BRAF	3.28005383260035
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	18/1911	44/9376	2.00713572142144	CREB3L1/PRKACA/RAB5C/DCTN1/RAB5A/ADCY3/CREB3L2/DYNLL2/DYNC1LI2/CREB1/RAB11B/CREB3/CREB5/DCTN2/DYNC2H1/ADCY9/ARHGDIB/DYNC1I2	3.38788023218957
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/1911	76/9376	1.74303891597125	AKT1/AKT2/GRB2/PTEN/SOS2/PLCG2/MAP2K2/MDM2/CDK4/BAX/CDKN1A/MAPK1/RB1/CDK6/PIK3CA/CDKN2A/CCND1/PRKCA/KRAS/IGF1/RAF1/HRAS/CALM3/CAMK2D/PDGFRB/ARAF/BRAF	3.29062170266706
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	39/1911	122/9376	1.56841753094681	CREB3L1/PRKACA/AKT1/BCAR1/AKT2/GRB2/ITPR2/SOS2/GNAQ/PLCG2/CREBBP/ADCY3/CRK/CREB3L2/MAP2K2/CACNA1C/GNA11/MAP2K3/MAPK1/SOCS1/CREB1/PIK3CA/MAPK10/MAP2K4/PRKCA/CRKL/CREB3/ATF6B/KRAS/IGF1/GNAI3/CREB5/RAF1/HRAS/ITPR1/ADCY9/CSH1/GHR/STAT3	3.19730235297595
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	19/1911	48/9376	1.94208965637537	ACAA2/ECHS1/AOX1/ALDH7A1/ALDH9A1/HMGCS1/HADHB/ACAT2/DLD/AUH/ABAT/ACAT1/PCCB/HSD17B10/BCAT2/MCEE/HIBADH/DBT/ACADS	3.31069872208138
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	16/1911	38/9376	2.06582390041037	GALK1/GMPPA/PMM2/UAP1/GPI/HK1/HEXA/NAGK/GFPT2/HEXB/PMM1/GALK2/GFPT1/PGM1/GMPPB/GNPDA2	3.33082176603323
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	54/1911	184/9376	1.43990171319364	PPP3CA/TRPC4/SEMA5A/PLXNB2/RHOD/NRP1/PLXNA3/RYK/PLCG2/ENAH/PPP3CB/RASA1/PARD3/PAK3/PTPN11/ABL1/PPP3R1/MAPK1/ROCK1/BMPR2/PIK3CA/NFATC4/SRGAP2/CXCR4/EPHA3/CDK5/EFNB1/BOC/SSH1/PRKCA/ROBO1/TRPC1/ILK/PAK2/WNT5B/KRAS/GNAI3/CFL2/UNC5B/SLIT3/RAF1/PLXNA4/HRAS/CAMK2D/ROBO2/PLXNA1/EFNA5/PAK1/TRPC6/CXCL12/RGMA/MYL5/EFNB2/LIMK2	3.04902252444524
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1911	101/9376	1.60305889301646	AKT1/AKT2/PLCG2/TGFBR2/DIAPH1/CCL2/CDK4/CDKN1B/BAX/MAPK1/COL1A1/VCAM1/PIK3CA/MAPK10/CCND1/PRKCA/SMAD4/COL4A4/COL4A5/RELA/FN1/TGFB1/KRAS/COL3A1/HRAS/CYBB/COL4A2/VEGFC/COL1A2/PIM1/STAT3/COL4A1/TGFB2	3.08293614556999
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	96/1911	362/9376	1.30112665550708	CREB3L1/COL6A2/CSF3R/HGF/CDC37/AKT1/AKT2/GRB2/PPP2R2A/MYC/COL6A1/PTEN/PPP2CB/FOXO3/PKN2/LAMB1/SOS2/STK11/PPP2R2D/RPS6KB1/PKN1/GNB1/FGF7/CREB3L2/MAP2K2/MDM2/PPP2R5C/TSC1/FGFR1/CDK4/BAD/CCND3/CDKN1B/YWHAG/CDKN1A/ITGA5/MAPK1/IFNAR1/COL1A1/YWHAH/CDK6/CREB1/PIK3CA/TNXB/VTN/G6PC3/LAMA2/PPP2R5D/CRTC2/ITGA4/MAGI1/TNC/CCND1/PRKCA/COL4A4/COL4A5/CREB3/RELA/GNB2/LAMC1/FN1/ITGAV/ATF6B/PPP2R1B/KRAS/IGF1/CCND2/CREB5/KITLG/LAMA4/RAF1/HRAS/RPS6KB2/PPP2R3C/ITGA3/CSH1/COL4A2/THBS3/NTRK1/VEGFC/GHR/EFNA5/FLT1/ERBB2/COL1A2/PDGFRB/THBS2/CSF1/EIF4EBP1/EPOR/NR4A1/RXRA/SPP1/COL4A1/JAK1/DDIT4	2.95628149386904
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	34/1911	105/9376	1.58871695198226	RAB5C/TFE3/FOXO3/RAB5A/TBC1D17/BCL2L13/TOMM70/HUWE1/EIF2S1/SMURF2/SAMM50/SP1/MON1B/CSNK2A1/ARIH1/FKBP8/MAP1LC3A/VCP/MAPK10/RABGEF1/SIAH1/MFN2/RELA/CSNK2A2/HIF1A/MTX1/KRAS/TOMM40/NBR1/HRAS/TFEB/RAB7B/FUNDC1/RHOT1	3.06929743258071
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/1911	157/9376	1.46877447696374	UQCRC1/NDUFA11/NDUFA13/SDHA/AKT1/MLX/AKT2/SDHD/NDUFA9/PRKAG2/NDUFA2/EIF2S1/NDUFS6/NDUFB5/ITCH/PRKAB2/MLXIP/BID/NDUFB10/NDUFB6/NDUFB7/SDHB/NDUFV1/BAX/NDUFS1/NDUFS7/UQCRFS1/UQCR11/PIK3CA/MAPK10/SREBF1/UQCRH/NDUFS8/RELA/GSK3A/NDUFB1/TGFB1/UQCRQ/NDUFA3/NDUFS2/COX6B1/DDIT3/NDUFA1/FAS/RXRA/NDUFV2/COX7A1	2.99690483463799
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	41/1911	133/9376	1.51247821280045	AKT1/AKT2/GRB2/PTEN/FOXO3/FBXO25/SOS2/CSNK1E/PRKAG2/STK11/PRMT1/CREBBP/HOMER3/TGFBR2/MAP2K2/MDM2/PRKAB2/CDKN1B/CDKN1A/MAPK1/KLF2/PIK3CA/MAPK10/ATM/G6PC3/CCND1/SMAD4/TGFB1/STK4/SETD7/KRAS/IGF1/CCND2/CAT/RAF1/HRAS/PLK2/ARAF/STAT3/TGFB2/BRAF	3.01158986163237
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/1911	23/9376	2.34650649557482	IDI1/ICMT/ZMPSTE24/GGPS1/HMGCS1/ACAT2/ACAT1/FDPS/PDSS2/HMGCR/DHDDS	3.27113132035052
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1911	106/9376	1.57372905620884	CREB3L1/AKT1/AKT2/GRB2/CTNNB1/PTEN/SOS2/PLAU/CREBBP/CREB3L2/MAP2K2/MDM2/FGFR1/BAD/CDKN1B/CDKN1A/MAPK1/RB1/CREB1/PIK3CA/ZEB1/CCND1/CREB3/RELA/KRAS/IGF1/CREB5/RAF1/HRAS/AR/ERBB2/PDGFRB/ARAF/BRAF	3.00552943967322
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	35/1911	110/9376	1.56110556110556	AKT1/AKT2/PFKL/RPS6KB1/EPAS1/PLCG2/CREBBP/MAP2K2/ALDOA/LTBR/CDKN1B/CDKN1A/MAPK1/LDHB/HK1/PIK3CA/PRKCA/PDHA1/RELA/CUL2/IFNGR2/HIF1A/IGF1/ELOC/CAMK2D/CYBB/RPS6KB2/PFKM/FLT1/ERBB2/MKNK1/EIF4EBP1/STAT3/PFKFB3/MKNK2	2.99499321841848
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	38/1911	122/9376	1.52820169681996	PRKACA/AKT1/MED13/AKT2/MYC/CTNNB1/RCAN1/PFKL/THRA/MED4/PLCG2/CREBBP/MAP2K2/MDM2/ATP1B1/ESR1/BAD/MAPK1/SLC9A1/PIK3CA/MED27/CCND1/PRKCA/ITGAV/HIF1A/ATP1A1/KRAS/NCOR1/NOTCH2/RAF1/HRAS/MED30/PFKM/MED16/NOTCH3/RXRB/BMP4/RXRA	2.97109155883231
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	46/1911	155/9376	1.45607265238602	CREB3L1/PRKACA/RAP1A/WNT2/KMT2A/ITPR2/CTNNB1/GNAQ/PBX1/ADCY3/CREB3L2/MAP2K2/DVL3/APC/CACNA1C/SP1/CDK4/CDKN1B/GNA11/AIP/CDKN1A/MAPK1/FH/RB1/CDK6/CREB1/CDKN2A/KCNA4/ASH2L/CCND1/CREB3/ATF6B/WNT5B/GNAI3/CREB5/LDLR/ITPR1/CAMK2D/STAR/ORAI1/ADCY9/FZD1/RASD1/NR4A1/BRAF/CYP11A1	2.89675619933276
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	58/1911	205/9376	1.38813288917819	AKT1/NFKB2/AKT2/MYC/PSMD13/PSMD11/PSMD4/PLCG2/SAP30/NCOR2/PSMD14/SAP30L/MDM2/BID/CDK4/PSMC2/PSMC1/PSMC4/CIR1/HLA-F/CCND3/CDKN1B/BAX/CDKN1A/MAP2K3/RELB/IFNAR1/RB1/PSMC5/CDK6/CD58/PIK3CA/MAPK10/MAP2K4/CCND1/MAP2K7/IRF3/RELA/TAB2/FADD/CCND2/PSMD12/PSMD2/HES1/MAVS/TRAF6/TAB1/ENTPD3/FAS/TRADD/TAPBPL/TYK2/NFKBIB/STAT3/JAK1/HLA-DPA1/MAP3K7/NEDD4	2.84282485970097
Human Diseases	Cancer: specific types	hsa05218	Melanoma	25/1911	73/9376	1.68025060392966	HGF/AKT1/AKT2/PTEN/FGF7/MAP2K2/MDM2/FGFR1/CDK4/BAD/BAX/CDKN1A/MAPK1/RB1/CDK6/PIK3CA/CDKN2A/CCND1/KRAS/IGF1/RAF1/HRAS/PDGFRB/ARAF/BRAF	2.95202432160095
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	14/1911	34/9376	2.02025425554837	POLR3D/POLR2E/POLR2G/POLR3A/POLR1A/POLR3GL/POLR1D/POLR2I/POLR2B/POLR2D/POLR3E/CRCP/POLR1E/POLR3K	3.01528951579657
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	30/1911	93/9376	1.58268766563697	RAP1A/CTNNB1/CTNND1/CREBBP/ACTN1/TGFBR2/LMO7/PARD3/SMURF2/FGFR1/CSNK2A1/ACP1/KRIT1/MAPK1/ROCK1/NECTIN2/SMAD4/CSNK2A2/ACTN4/CCM2/NECTIN3/WASF3/PTPRJ/PTPN6/ERBB2/TJP1/MYL5/HEG1/MAP3K7/VCL	2.85715762080767
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	64/1911	232/9376	1.35347083130334	MYH10/DIAPH2/AKT1/BCAR1/AKT2/SOS2/IQGAP2/DOCK1/ARPC5L/PPP1CC/ACTN1/FGF7/PPP1R12C/CRK/MAP2K2/ENAH/APC/CYFIP1/PPP1R12B/DIAPH1/PPP1CA/PAK3/FGFR1/PIP5K1C/ITGA5/MAPK1/PPP1R12A/ROCK1/NCKAP1/SLC9A1/PIK3CA/ACTR2/CXCR4/ITGA4/SSH1/CRKL/RDX/ACTN4/FN1/ITGAV/PAK2/KRAS/CFL2/ARHGAP35/RAF1/HRAS/ITGAX/ITGA3/PIKFYVE/PAK1/CXCL12/SPATA13/MYH9/PDGFRB/MYLK/MYL5/ARAF/ARPC3/BRK1/BRAF/LIMK2/VCL/ABI2/ITGAE	2.75823039979896
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	34/1911	109/9376	1.53041541245997	CREB3L1/AKT1/MLX/AKT2/OGA/PTEN/PRKAG2/RPS6KB1/PPP1CC/NR1H2/CREB3L2/PRKAB2/MLXIP/PPP1CA/PTPN11/CREB1/PIK3CA/MAPK10/SREBF1/G6PC3/SLC27A1/CRTC2/GFPT2/CD36/CREB3/RELA/RPS6KA3/CREB5/PYGM/RPS6KB2/PYGL/GFPT1/STAT3/ACACB	2.81812905903459
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	36/1911	117/9376	1.50964054260758	PBRM1/INO80/POLE3/ZNHIT1/CHD3/MBD3/SMARCA1/MRGBP/EPC1/RBBP7/BAZ2A/ARID1A/PHF6/MEAF6/SMARCC2/MTA3/MBD2/SMARCA5/BPTF/BRD9/VPS72/BICRAL/NFRKB/SMARCB1/PHF10/CHD4/BAZ2B/ARID1B/EP400/UCHL5/DPF2/ARID2/RSF1/MCRS1/SMARCC1/GATAD2B	2.80657035744008
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	38/1911	125/9376	1.49152485609628	S1PR3/AKT1/AKT2/PPP2R2A/PTEN/PPP2CB/SGPP1/SGMS1/PPP2R2D/GNAQ/MAP2K2/PPP2R5C/DEGS1/NSMAF/ORMDL3/BID/SPTLC1/SPTLC2/BAX/MAPK1/ROCK1/CERS2/PIK3CA/MAPK10/SGMS2/PPP2R5D/PRKCA/RELA/CERS5/PPP2R1B/KRAS/GNAI3/ORMDL1/RAF1/HRAS/SPHK1/PPP2R3C/TRADD	2.79902789364757
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	49/1911	170/9376	1.41417797888386	PBRM1/HGF/AKT1/WNT2/AKT2/GRB2/MYC/CTNNB1/PTEN/SOS2/RPS6KB1/PLCG2/TGFBR2/MAP2K2/ARID1A/DVL3/APC/SMARCC2/CDK4/BAD/BAX/CDKN1A/KEAP1/MAPK1/RB1/CDK6/GSTM5/PIK3CA/CDKN2A/CCND1/PRKCA/SMAD4/SMARCB1/PHF10/GSTA4/TGFB1/WNT5B/KRAS/ARID1B/RAF1/HRAS/RPS6KB2/ARID2/GSTM2/FZD1/ARAF/SMARCC1/TGFB2/BRAF	2.75725577874221
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	23/1911	67/9376	1.68426314268532	PPP3CA/PRKACA/RAP1A/ITPR2/GNAQ/PPP1CC/CREBBP/MAP2K2/PPP3CB/CACNA1C/PPP1CA/PPP3R1/MAPK1/PRKCA/RPS6KA3/KRAS/RAF1/HRAS/CALM3/ITPR1/CAMK2D/ARAF/BRAF	2.84387242083731
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	29/1911	90/9376	1.58092912378627	PPP3CA/AKT1/AKT2/PTEN/RPS6KB1/MAP2K2/PPP3CB/CSNK2A1/PTPN11/PPP3R1/MAP2K3/MAPK1/PIK3CA/BATF3/EML4/RELA/CSNK2A2/IFNGR2/HIF1A/KRAS/RAF1/HRAS/TRAF6/RPS6KB2/PTPN6/MAP3K3/NFKBIB/STAT3/JAK1	2.80176135233725
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	20/1911	56/9376	1.75226134409808	MAN1A2/FUT8/ALG3/DPM2/MAN1B1/TUSC3/DPM1/B4GALT2/KRTCAP2/MGAT4B/ALG2/MAN2A1/MAN1A1/DPM3/RPN1/ALG13/ALG5/ALG10/ALG12/MOGS	2.85664240446187
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	25/1911	75/9376	1.63544392115821	IDH3G/TKT/PFKL/PYCR2/ASS1/IDH2/ASL/ALDOA/ACO1/RPE/ACO2/PYCR3/SHMT2/GOT2/IDH3B/IDH1/TALDO1/MTR/MAT2B/PRPS1/PFKM/PYCR1/BCAT2/PC/SDSL	2.79540099021816
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	25/1911	75/9376	1.63544392115821	SIVA1/EI24/PTEN/SHISA5/ZNF385A/SESN1/MDM2/BID/RCHY1/CDK4/CCND3/BAX/CDKN1A/MDM4/CDK6/ATM/CDKN2A/CCND1/SIAH1/SESN3/IGF1/CCND2/RPRM/PIDD1/FAS	2.79540099021816
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	33/1911	107/9376	1.51316774013703	CREB3L1/PPP3CA/PRKACA/PPP4C/AKT1/AKT2/ITPR2/PFKL/PRKAG2/GNAQ/PRMT1/CREBBP/CREB3L2/PPP3CB/PRKAB2/PPP3R1/LDHB/CREB1/G6PC3/CRTC2/PDHA1/CREB3/PHKB/CREB5/CALM3/ITPR1/CAMK2D/PYGM/PFKM/ACACA/PYGL/PHKG1/ACACB	2.70107019342693
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	79/1911	300/9376	1.29200069771498	PPP3CA/PRKACA/HGF/CACNA2D1/RAP1A/MAP3K8/MAX/AKT1/DUSP3/NFKB2/AKT2/GRB2/MYC/MAP3K13/SOS2/FGF7/CRK/TGFBR2/MAP2K2/MAP4K4/PPP3CB/RASA1/CACNA1C/DUSP6/FGFR1/TAOK1/NF1/MAP4K3/PPP3R1/MAP2K3/RELB/MAPK1/MAP3K4/ELK4/MAPK10/MAP2K4/PRKCA/MAP2K7/CRKL/RELA/TGFB1/STK4/PAK2/TAB2/RPS6KA3/KRAS/IGF1/PPM1A/KITLG/PLA2G4C/FLNA/STMN1/RAF1/HRAS/IL1RAP/TRAF6/DDIT3/TAB1/NTRK1/VEGFC/EFNA5/PAK1/CACNB3/FLT1/ERBB2/MAP3K3/ECSIT/PDGFRB/FAS/TRADD/MKNK1/CSF1/LAMTOR3/ARAF/NR4A1/TGFB2/MAP3K7/BRAF/MKNK2	2.60074845172283
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	45/1911	156/9376	1.4152880086946	AKT1/AKT2/GRB2/PPP2R2A/MYC/CTNNB1/PPP2CB/SOS2/PPP2R2D/EIF2S1/MAP2K2/BID/CDK4/BAD/YWHAG/BAX/CDKN1A/MAPK1/IFNAR1/EIF3E/RB1/YWHAH/CDK6/PIK3CA/CCND1/IRF3/RELA/FADD/PPP2R1B/KRAS/PSME3/MAVS/LDLR/RAF1/HRAS/TRAF6/FAS/TRADD/ARAF/TYK2/RXRA/CFLAR/STAT3/JAK1/BRAF	2.64635014084763
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	13/1911	32/9376	1.99319727891156	ECHS1/DLD/ABAT/LDHB/PCCB/ACSS3/ACACA/MLYCD/MCEE/SUCLG1/DBT/ACADS/ACACB	2.84737830047652
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/1911	19/9376	2.32405188796166	GUSB/HGSNAT/IDUA/HYAL2/NAGLU/GALNS/HEXA/GLB1/HEXB	2.92290409916862
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	22/1911	65/9376	1.66060459686833	CREB3L1/PRKACA/ITPR2/GNAQ/PBX1/ADCY3/CREB3L2/CACNA1C/SP1/GNA11/CREB1/KCNA4/CREB3/ATF6B/CREB5/LDLR/ITPR1/STAR/ORAI1/ADCY9/NR4A1/CYP11A1	2.70396572418337
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	63/1911	233/9376	1.32660472574636	MYH10/COL6A2/DIAPH2/SYNPO2/COL6A1/COL5A1/SGCE/SNTB2/SDC4/PDLIM7/DAG1/HSPG2/ZYX/AMPD2/ATP1B1/DIAPH1/AGRN/SSPN/SYNE1/LMOD1/TMEM43/ITGA5/COL1A1/FHL1/BGN/LAMA2/CSRP1/SNTB1/COL5A3/ITGA4/COL4A4/COL4A5/LMNA/PDLIM5/FN1/ITGAV/ATP1A1/FMNL2/COL5A2/EMD/COL3A1/SPTAN1/LBR/FLNC/ITGA3/COL4A2/FHL3/THBS3/DES/SGCD/NEBL/COL1A2/MYH9/THBS2/MYL5/AMPD3/SUN1/COL4A1/FMNL1/VCL/SYNE2/SDC2/CAPZB	2.55421317497151
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	28/1911	89/9376	1.54356504918303	COL6A2/COL6A1/LAMB1/SDC4/DAG1/HSPG2/AGRN/ITGA5/COL1A1/TNXB/VTN/LAMA2/ITGA4/TNC/CD36/COL4A4/COL4A5/LAMC1/FN1/ITGAV/LAMA4/ITGA3/COL4A2/THBS3/COL1A2/THBS2/SPP1/COL4A1	2.60681301365116
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	29/1911	93/9376	1.52993141011574	MAX/AKT1/AKT2/MYC/PTEN/LAMB1/CDK4/CDKN1B/BAX/CDKN1A/RB1/XIAP/CDK6/PIK3CA/LAMA2/CCND1/COL4A4/COL4A5/RELA/LAMC1/FN1/ITGAV/LAMA4/TRAF6/ITGA3/COL4A2/RXRB/RXRA/COL4A1	2.59847197084975
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	13/1911	33/9376	1.93279736136879	IDH3G/DLD/DLAT/IDH2/OGDH/ACO1/ACO2/GOT2/PDHA1/IDH3B/IDH1/BCAT2/DBT	2.71582749081326
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	40/1911	138/9376	1.42212514883322	PPP3CA/PRKACA/ANAPC5/ITPR2/PPP2CB/SMC3/FBXW11/ANAPC16/PPP1CC/ADCY3/PPP3CB/PPP2R5C/ANAPC7/PPP1CA/CDC23/CDC27/YWHAG/ANAPC13/PPP3R1/MAPK1/CDC26/YWHAH/PPP2R5D/BTRC/ANAPC1/ANAPC10/RPS6KA3/PPP2R1B/IGF1/SLK/PGR/ANAPC11/CALM3/ITPR1/ANAPC4/CAMK2D/ADCY9/MAD1L1/AR/CDC16	2.52750990789042
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	38/1911	130/9376	1.4341585154772	CREB3L1/PRKACA/AKT1/AKT2/GRB2/SOS2/GNB1/ADCY3/ACTA2/TGFBR2/CREB3L2/MAP2K2/MAPK1/COL1A1/CREB1/PIK3CA/MAPK10/MAP2K4/PRKCA/MAP2K7/COL4A4/COL4A5/CREB3/RELA/GNB2/TGFB1/ATF6B/KRAS/GNAI3/CREB5/COL3A1/RAF1/HRAS/ADCY9/COL4A2/VEGFC/COL1A2/COL4A1	2.5219944753937
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	16/1911	44/9376	1.7841206412635	MAN1A2/FUT8/ALG3/MAN1B1/TUSC3/B4GALT2/KRTCAP2/MGAT4B/ALG2/MAN2A1/MAN1A1/HEXA/RPN1/HEXB/ALG13/ALG12	2.63768503458413
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	30/1911	98/9376	1.50193829494121	PTPRC/AKT1/AKT2/BIN1/ARF6/DOCK1/RPS6KB1/ARPC5L/PLCG2/ASAP2/CRK/DNM2/PIP5K1C/MAPK1/PIK3CA/ACTR2/FCGR2A/PRKCA/CRKL/ASAP1/CFL2/PLA2G4C/RAF1/SPHK1/RPS6KB2/WASF3/NCF1/PAK1/ARPC3/LIMK2	2.52718631129956
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	14/1911	37/9376	1.85644985644986	GALK1/GMPPA/PMM2/CMAS/UAP1/GPI/HK1/NAGK/GFPT2/PMM1/GALK2/GFPT1/PGM1/GMPPB	2.64091054650382
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1911	37/9376	1.85644985644986	MYC/CTNNB1/MAP2K2/BAX/CDKN1A/MAPK1/CCND1/KRAS/HRAS/NTRK1/RXRB/RXRA/TPR/BRAF	2.64091054650382
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	24/1911	75/9376	1.57002616431188	XPA/AKT1/MSH3/AKT2/TOP2B/MDM2/BID/BAD/BAX/CDKN1A/SLC31A1/MAPK1/XIAP/GSTM5/PIK3CA/ATM/CDKN2A/GSTA4/REV3L/FADD/GSTM2/ERBB2/FAS/MLH1	2.50761971451917
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	41/1911	144/9376	1.39694168265597	AKT1/AKT2/ITPR2/PUM2/RORA/PSMD13/PSMD11/ATXN3/GNAQ/PSMD4/PSMD14/PSMB4/VDAC3/ATXN1/ATG14/SP1/ATXN2/PSMC2/PSMC1/PSMC4/NOP56/PSMB6/PSMC5/PIK3CA/MAPK10/SLC25A6/KCND3/PSMA6/PRKCA/PSMB3/PSMD12/PSMD2/GTF2B/PSMB7/PSMB5/ITPR1/ATXN1L/PIK3R4/GRIA3/ATG13/ATG2B	2.42862874063791
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/1911	56/9376	1.66464827689317	PRKACA/SCUBE2/CUL3/FBXW11/SPOP/CSNK1E/CDON/CSNK1G3/EVC/SMURF2/CSNK1G2/MGRN1/GLI3/BTRC/BOC/CCND1/CCND2/KIF3A/SPOPL	2.52393994018389
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	13/1911	34/9376	1.87595038015206	RORA/FBXW11/CSNK1E/PRKAG2/BHLHE40/PRKAB2/CRY2/CREB1/PER3/BTRC/NR1D2/BHLHE41/PER1	2.58880958669552
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	35/1911	120/9376	1.43101343101343	RAP1A/AKT1/AKT2/GRB2/FOXO3/SOS2/PLCG2/CRK/MAP2K2/BAD/PTPN11/ABL1/BAX/MAPK1/PIK3CA/MAPK10/MAP2K7/CRKL/RELA/BEX3/RPS6KA3/KRAS/SORT1/RAPGEF1/MAGED1/RAF1/HRAS/CALM3/CAMK2D/TRAF6/NTRK1/MAP3K3/ARHGDIB/NFKBIB/BRAF	2.40420130956635
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	12/1911	31/9376	1.89922519876437	GCSH/GRHPR/ACAT2/DLD/ACO1/ACAT1/ACO2/PCCB/SHMT2/CAT/PGP/MCEE	2.53723526066349
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	55/1911	205/9376	1.31633291215173	CREB3L1/PRKACA/UBR4/NFKB2/GRB2/ATP6V0D1/DDB1/GTF2E2/CREBBP/ACTN1/CREB3L2/VDAC3/MDM2/MRPS18B/SND1/CDK4/PSMC1/BAD/LTBR/HLA-F/CCND3/CDKN1B/YWHAG/BAX/DLG1/CDKN1A/MAPK1/RANBP1/RB1/YWHAH/CDK6/CREB1/PIK3CA/CDKN2A/HDAC4/CCND1/IRF3/CREB3/RELA/ACTN4/CHD4/ATF6B/KRAS/CCND2/CREB5/GTF2H3/GTF2B/HRAS/HDAC11/MAD1L1/SCRIB/DNAJA3/TRADD/STAT3/JAK1	2.31693600743453
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	39/1911	138/9376	1.38657202011239	AKT1/BCAR1/AKT2/ARF6/PKN2/SKAP2/DOCK1/GNAQ/PKN1/ARPC5L/CRK/MAP2K2/CCL2/PIP5K1C/ITGA5/MAP2K3/WIPF2/MAPK1/ROCK1/PIK3CA/MAPK10/MAP2K4/ACTR2/FCGR2A/ITGA4/MAP2K7/IRF3/CRKL/RELA/FN1/TAB2/RPS6KA3/RHOG/TRAF6/TAB1/FYB1/ARPC3/MAP3K7/PYCARD	2.3146325530425
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1911	85/9376	1.50076030412165	NME3/IMPDH2/NME4/NT5C/AMPD2/ADK/DCTD/DUT/NME6/TK2/ASMTL/NME1/GMPR2/APRT/NT5C3A/TYMP/UCK2/DTYMK/ENTPD4/UPP1/AK9/ENTPD3/ADA/AMPD3/NT5C3B/LACC1	2.34643864675931
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	18/1911	54/9376	1.63544392115821	GCLM/DNMT1/AHCYL1/AHCY/LDHB/SMS/SRM/APIP/GOT2/MRI1/KYAT3/MPST/MTR/MAT2B/BCAT2/ENOPH1/SDSL/LACC1	2.3693031715435
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1911	110/9376	1.4272965130108	MYC/PPP2CB/RPS6KB1/CREBBP/TGFBR2/SKI/SMURF2/SP1/INHBB/MAPK1/ROCK1/BMPR2/RGMB/ZFYVE9/SMAD4/TGFB1/ID2/CHRD/PPP2R1B/LEMD3/NCOR1/LTBP1/ID3/FMOD/ACVR1/PITX2/HFE/BMP5/RPS6KB2/BMP4/RGMA/TGFB2	2.28076541640343
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	16/1911	47/9376	1.67024060033179	ALDH7A1/ALDH9A1/GRHPR/AKR1A1/ACAT2/DLD/DLAT/ACAT1/GLO1/LDHB/FH/ME2/PDHA1/ACACA/PC/ACACB	2.3305755723712
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	38/1911	137/9376	1.36088034315354	AKT1/AKT2/ITPR2/HTRA2/EIF2S1/MAP2K2/CAPN1/BID/CTSS/BAD/BAX/MAPK1/XIAP/TUBA1C/PIK3CA/MAPK10/ATM/PARP3/RELA/LMNA/CTSZ/FADD/KRAS/CTSC/CAPN2/SPTAN1/TUBA4A/RAF1/HRAS/ITPR1/CASP6/DDIT3/NTRK1/ENDOG/PIDD1/FAS/TRADD/CFLAR	2.15284172855392
NA	NA	hsa04517	IgSF CAM signaling	75/1911	299/9376	1.23068522495183	MYH10/ERC1/RAP1A/PVR/AKT1/BCAR1/AKT2/GRB2/CTNNB1/ARF6/NRP1/PLXNA3/ARPC5L/PLCG2/ACTN1/MAP2K2/LMO7/MPDZ/RASA1/PARD3/PAK3/FGFR1/PTPN11/ABL1/DYNLL2/ITGA5/MAPK1/NECTIN2/TUBA1C/PIK3CA/MAPK10/ACTR2/SRGAP2/KCNQ3/KCNA4/ITGA4/MAGI1/TRIO/PRKCA/EPB41L3/NFASC/ROBO1/EPB41L2/RDX/ACTN4/MYL6B/PAK2/NRP2/UNC5B/NLGN2/EPB41L1/SPTAN1/SLIT3/TUBA4A/PLXNA4/NLGN4X/NECTIN3/CADM3/IL1RAP/TRAF6/ITGAX/MBP/ROBO2/PLXNA1/FGB/PAK1/TRPC6/PTPN6/CDH2/MYH9/TJP1/MYLK/TUBB6/ARPC3/VCL	2.05109266549216
Organismal Systems	Nervous system	hsa04730	Long-term depression	19/1911	60/9376	1.5536717251003	ITPR2/PPP2CB/GNAQ/MAP2K2/GNA11/MAPK1/GUCY1A1/PRKCA/PPP2R1B/KRAS/IGF1/GNAI3/PLA2G4C/RAF1/HRAS/ITPR1/GRIA3/ARAF/BRAF	2.17677883690479
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	34/1911	122/9376	1.3673383603126	PPP3CA/PTPRC/MAP3K8/AKT1/AKT2/GRB2/PPP2R2A/PPP2CB/SOS2/PPP2R2D/MAP2K2/PPP3CB/PPP2R5C/PAK3/CDK4/PTPN11/PPP3R1/DLG1/MAPK1/PIK3CA/MAPK10/PPP2R5D/MAP2K7/RELA/PAK2/PPP2R1B/KRAS/RAF1/HRAS/PPP2R3C/PAK1/PTPN6/NFKBIB/MAP3K7	2.06624838225778
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	31/1911	110/9376	1.38269349697921	PRKACA/ANAPC5/AKT1/AKT2/ANAPC16/KIF22/ADCY3/ANAPC7/CDC23/CDC27/ANAPC13/MAPK1/CDC26/PIK3CA/MAPK10/ANAPC1/ANAPC10/RPS6KA3/KRAS/IGF1/GNAI3/PGR/ANAPC11/RAF1/ANAPC4/ADCY9/MAD1L1/FZR1/CDC16/ARAF/BRAF	2.04268948239841
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/1911	57/9376	1.54936792530778	ACAA2/ECHS1/ELOVL5/HADHB/TECR/ACAT2/FADS2/ACAT1/ACSL3/HACD4/HACD1/ACACA/FASN/CPT2/CBR4/MCAT/FADS1/ACADS	2.10483059243192
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	39/1911	144/9376	1.32879818594104	PCGF5/MEIS1/AKT1/WNT2/AKT2/GRB2/MYC/CTNNB1/PCGF2/MAP2K2/DVL3/SMARCAD1/APC/KAT6A/FGFR1/RIF1/INHBB/ZFHX3/MAPK1/BMPR2/PIK3CA/JARID2/SMAD4/ID2/BMI1/WNT5B/KRAS/IGF1/ID3/RAF1/HRAS/ACVR1/FZD1/BMP4/REST/PCGF3/STAT3/JAK1/SETDB1	2.01170287509995
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1911	119/9376	1.3605793965938	CREB3L1/ADAM17/MAP3K8/AKT1/AKT2/CREB3L2/ITCH/CCL2/DNM1L/MAP2K3/MAPK1/VCAM1/XIAP/CREB1/PIK3CA/MAPK10/MAP2K4/MAP2K7/CREB3/RELA/IL15/ATF6B/TAB2/FADD/CREB5/RHBDF1/TAB1/VEGFC/FAS/TRADD/CSF1/CFLAR/MAP3K7	2.00281267936553
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	52/1911	201/9376	1.26929975970488	KLF3/HOXA10/MEIS1/MAX/FUT8/TFE3/EWSR1/KMT2A/MYC/ASPSCR1/TAF15/AFF1/PBX1/PLAU/JMJD1C/TGFBR2/MDM2/RUNX1T1/LDB1/DUSP6/CDK9/SP1/PBX3/CDKN1B/FUS/MLLT1/BAX/CCNT2/CDKN1A/PML/ELK4/ATM/ZEB1/PROM1/BMP2K/RELA/ID2/BMI1/IGF1/NCOR1/CCND2/CDK14/MLLT3/ZBTB16/HOXA9/ETV6/DDIT3/NTRK1/RXRB/GRIA3/FLT1/RXRA	1.95268429722371
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	42/1911	158/9376	1.3042147725692	AKT1/WNT2/AKT2/GRB2/PTEN/SOS2/STK11/RPS6KB1/ATP6V1A/MAP2K2/DVL3/TSC1/TELO2/MAPK1/ATP6V1C1/PIK3CA/PRKCA/TTI1/LAMTOR4/RICTOR/RPS6KA3/WNT5B/KRAS/IGF1/ATP6V1H/CLIP1/NPRL2/RAF1/HRAS/LPIN2/STRADB/RPS6KB2/NPRL3/FLCN/FZD1/DEPDC5/LAMTOR3/EIF4EBP1/ATP6V1E1/BRAF/LAMTOR1/DDIT4	1.95115408138855
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	29/1911	103/9376	1.38139438000742	PRKACA/RAB5C/RAB5A/LAMB1/GNAQ/ACTN1/GNA11/COL1A1/PIK3CA/LAMA2/PRKCA/COL4A4/COL4A5/RELA/ACTN4/LAMC1/FN1/TGFB1/SERPINB6/COL3A1/LAMA4/COL4A2/RAB7B/COL1A2/SERPINB9/COL4A1/TGFB2/PRDX1/VCL	1.96917288681241
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	28/1911	99/9376	1.38764938764939	AKT1/AKT2/GRB2/PCYT1A/SOS2/RPS6KB1/MAP2K2/TSC1/SP1/PIP5K1C/MAPK1/PIK3CA/MAPK10/DGKD/PRKCA/SLC44A2/HIF1A/KRAS/PLA2G4C/RAF1/HRAS/RPS6KB2/WASF3/SLC22A3/RALGDS/DGKZ/PDGFRB/EIF4EBP1	1.96179668785425
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	13/1911	39/9376	1.63544392115821	GCSH/ALDH7A1/ATIC/AHCYL1/DLD/AHCY/SHMT2/MTHFD1L/GART/MTR/DHFR2/DMGDH/MAT2B	2.01190249528624
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	21/1911	71/9376	1.4511685497601	AKT1/AKT2/GRB2/FOXO3/SOS2/MAP2K2/ESR1/MAPK1/SOCS1/PIK3CA/MAPK10/CCND1/RELA/KRAS/SOCS4/CCND2/RAF1/HRAS/CISH/CGA/STAT3	1.93068258574775
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/1911	59/9376	1.49684697868717	NME3/NME4/NT5C/DCTD/DUT/NME6/TK2/ASMTL/NME1/NT5C3A/TYMP/UCK2/DTYMK/ENTPD4/UPP1/AK9/ENTPD3/NT5C3B	1.93692001536092
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	17/1911	55/9376	1.51650254507397	SGPP1/SGMS1/ACER3/DEGS1/SPTLC1/SPTLC2/CERK/CERS2/HEXA/SGMS2/CERS5/GLB1/GALC/HEXB/SPHK1/GM2A/SAMD8	1.94367492662831
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	39/1911	148/9376	1.29288472145615	AKT1/WNT2/NFKB2/AKT2/GRB2/MYC/CTNNB1/PTEN/SOS2/RPS6KB1/FGF7/MAP2K2/DVL3/APC/ESR1/SP1/FGFR1/CDK4/BAX/CDKN1A/MAPK1/RB1/CDK6/PIK3CA/CCND1/WNT5B/KRAS/IGF1/PGR/NOTCH2/HES1/RAF1/HRAS/RPS6KB2/NOTCH3/FZD1/ERBB2/ARAF/BRAF	1.8170833856079
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1911	21/9376	1.86907876703795	CHPF2/CHST11/CSGALNACT2/DSEL/B3GALT6/CHST12/CHSY3/B4GALT7	2.01719538873829
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1911	157/9376	1.28127135224496	WNT2/TEAD1/PPP2R2A/MYC/CTNNB1/PPP2CB/FBXW11/CSNK1E/PPP2R2D/PPP1CC/TGFBR2/DVL3/APC/PARD3/PPP1CA/CCND3/YWHAG/DLG1/BMPR2/YWHAH/BTRC/WTIP/CCND1/SMAD4/YAP1/TGFB1/ID2/PPP2R1B/DLG5/WNT5B/CCND2/RASSF1/TEAD3/LATS1/BMP5/FZD1/SCRIB/BMP4/DLG4/TGFB2/NKD1	1.79818551736831
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	26/1911	93/9376	1.37166264355204	PRKACA/GRB2/ITPR2/SOS2/GNAQ/ADCY3/MAP2K2/CACNA1C/GNA11/MAP2K3/MAPK1/MAP3K4/MAPK10/MAP2K4/PRKCA/MAP2K7/KRAS/PLA2G4C/RAF1/HRAS/CALM3/ITPR1/CAMK2D/ADCY9/CGA/MAP3K3	1.82241502097598
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	37/1911	140/9376	1.29667339463258	PRKACA/AKT1/AKT2/ITPR2/PRKAG2/MEF2D/RPS6KB1/GNAQ/GNB1/ADCY3/ACTA2/MAP2K2/MEF2A/PRKAB2/TFAM/MAP1LC3A/MAPK1/KLF2/SLC9A1/HDAC4/CCND1/SMAD4/GNB2/KRAS/GNAI3/RAF1/HRAS/SPHK1/CALM3/ITPR1/RPS6KB2/ADCY9/NOTCH3/SLC8A1/PIK3R4/MYLK/SPP1	1.78937651221143
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1911	44/9376	1.56110556110556	TAF3/GTF2F1/GTF2E2/TAF15/TAF9/GTF2I/TAF6/TAF13/GTF2H3/CCNH/GTF2B/TAF8/TAF4/CDK7	1.8874898369787
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/1911	44/9376	1.56110556110556	POLE3/UNG/MPG/SMUG1/NTHL1/PNKP/MBD4/PARP3/PARG/POLG2/POLL/OGG1/POLD2/APTX	1.8874898369787
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	40/1911	154/9376	1.27437188661678	PPP3CA/PRKACA/CACNA2D1/ITPR2/RCAN1/PRKAG2/CAMKK2/GNAQ/PPP1CC/ADCY3/PPP1R12C/MAP2K2/PPP3CB/PRKAB2/PPP1R12B/CACNA1C/PPP1CA/PPP3R1/CDKN1A/MAPK1/PPP1R12A/ROCK1/NFATC4/GUCY1A1/CCND1/PRKCA/MYL6B/KRAS/GNAI3/PLA2G4C/RAF1/HRAS/CALM3/ITPR1/CAMK2D/ADCY9/CACNB3/EEF2K/MYLK/OXTR	1.73695467829688
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	7/1911	18/9376	1.90801790801791	MANBA/MAN2B2/HEXA/AGA/MAN2C1/GLB1/HEXB	1.95092341706261
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	19/1911	65/9376	1.4341585154772	TRPC4/AKT1/AKT2/ITPR2/GNAQ/MAP2K2/CACNA1C/GNA11/MAPK1/PIK3CA/PRKCA/TRPC1/KRAS/GABBR1/RAF1/HRAS/ITPR1/CGA/SPP1	1.77708382635832
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	45/1911	178/9376	1.24036477166493	PPP3CA/PRKACA/WNT2/MYC/CTNNB1/FBXW11/CSNK1E/RYK/CREBBP/DVL3/APC/PPP3CB/CSNK2A1/CCND3/PPP3R1/PRICKLE2/MAPK10/NFATC4/CBY1/SFRP1/BTRC/CCND1/SIAH1/PRKCA/SMAD4/TLE4/CSNK2A2/WNT5B/MCC/CCND2/CTBP1/CHD8/VANGL1/SENP2/CAMK2D/TLE1/INVS/ROR1/FZD1/CCAR2/TBL1X/SERPINF1/TBL1XR1/MAP3K7/NKD1	1.6380803141958
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1911	30/9376	1.63544392115821	DPM2/PIGX/PIGG/PIGQ/GPAA1/PIGH/PIGF/PIGS/PIGB/PIGC	1.76370539827012
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	42/1911	166/9376	1.24136104858996	CREB3L1/ATP2B1/PPP3CA/AKT1/AKT2/ITPR2/MEF2D/GNAQ/PPP1CC/ADCY3/CREB3L2/MAP2K2/GTF2I/MEF2A/VDAC3/PPP3CB/ATP1B1/CACNA1C/PPP1CA/BAD/GNA11/PPP3R1/MAPK1/PPP1R12A/ROCK1/CREB1/NFATC4/SLC25A6/GUCY1A1/CREB3/ATF6B/ATP1A1/GNAI3/CREB5/RAF1/CALM3/ITPR1/ADCY9/SLC8A1/TRPC6/KCNMA1/MYLK	1.58742234248994
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	45/1911	180/9376	1.22658294086866	AKT1/AKT2/SRSF4/PPP1CC/EIF2S1/TSC1/ALYREF/BID/PPP1CA/POU2F1/CCL2/BAD/PTPN11/HLA-F/BAX/ITGA5/PML/IFNAR1/NECTIN2/PIK3CA/PILRB/IRF3/RELA/IFNGR2/TAB2/FADD/PILRA/MAVS/EIF2B1/SRSF1/TNFRSF14/CARD9/TRAF6/TAB1/SRPK1/FAS/TRADD/EIF4EBP1/TAPBPL/TYK2/JAK1/HLA-DPA1/CGAS/MAP3K7/NXF1	1.55297711617321
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	11/1911	35/9376	1.54198998280631	GMPPA/PFKL/PMM2/AKR1B1/TIGAR/ALDOA/HK1/PMM1/PFKM/GMPPB/PFKFB3	1.62528554076754
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	26/1911	98/9376	1.30167985561572	MTMR6/INPP5A/ITPR2/PTEN/PLCG2/PI4KB/PIP5K1C/PIK3C2A/IP6K2/PIK3CA/ITPKC/DGKD/IMPA1/PRKCA/PI4K2A/MTMR2/CALM3/ITPR1/PI4KA/INPP5B/INPP4A/PIKFYVE/SACM1L/IPPK/DGKZ/PIP4P1	1.51891419561076
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1911	142/9376	1.24385875693723	PPP3CA/AKT1/NFKB2/AKT2/GRB2/ITPR2/PLCG2/TGFBR2/PPP3CB/PPP3R1/RELB/MAPK1/IFNAR1/SOCS1/CREB1/PIK3CA/MAPK10/FCGR2A/MAP2K7/RELA/TGFB1/IFNGR2/TAB2/TYROBP/ITPR1/TRAF6/TAB1/NCF2/NCF1/CSF1/TYK2/ACP5/JAK1/TGFB2/MAP3K7/CYBA	1.48145569711775
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	36/1911	142/9376	1.24385875693723	TXN2/AKT1/AKT2/CTNNB1/GPC1/SDC4/ASS1/MEF2A/PIAS4/CCL2/SUMO3/KEAP1/VCAM1/BMPR2/KLF2/GSTM5/PIK3CA/MAPK10/MAP2K4/SUMO1/ARHGEF2/MAP2K7/RELA/GSTA4/ITGAV/CAV2/CALM3/ACVR1/GSTM2/NCF2/NCF1/BMP4/MAP3K7/CAV1/SDC2/CYBA	1.48145569711775
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/1911	52/9376	1.4152880086946	VAPB/STARD3NL/VDAC3/PLTP/CD36/TSPO/LIPA/LRP1/SORT1/LDLR/APOE/STAR/LDLRAP1/STARD3/MYLIP	1.5193261271659
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	34/1911	134/9376	1.24489014894132	MYH10/PRKACA/ITPR2/GNAQ/PPP1CC/ADCY3/PPP1R12C/ACTA2/MAP2K2/PPP1R12B/CACNA1C/AVPR1A/RAMP2/PPP1CA/PLA2G12A/GNA11/MAPK1/PPP1R12A/ROCK1/CALCRL/GUCY1A1/PRKCA/MYL6B/PLA2G4C/PPP1R14A/RAF1/CALM3/ITPR1/ADCY9/KCNMA1/MYH9/MYLK/ARAF/BRAF	1.44458069958591
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	10/1911	32/9376	1.53322867608582	GALK1/PFKL/AKR1B1/B4GALT2/HK1/G6PC3/GLB1/PFKM/PGM1/GAA	1.52870310231063
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/1911	53/9376	1.38858446136074	ATP2B1/PRKACA/AP2A1/AP2B1/GNAQ/AP2S1/ATP1B1/DNM2/ESR1/PRKCA/ATP1A1/AP2M1/AP2A2/ADCY9/SLC8A1	1.4353129343246
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	60/1911	253/9376	1.16355693995446	AKT1/BCAR1/AKT2/ITPR2/SHARPIN/FOXO3/ARF6/FBXW11/DOCK1/RPS6KB1/ARPC5L/PLCG2/ACTN1/FNBP1/CRK/CAPN1/ATG14/MDM2/DIAPH1/BAX/MAP1LC3A/ITGA5/MAPK1/ROCK1/HK1/PIK3CA/MAPK10/ATM/ACTR2/BTRC/ARHGEF2/IRF3/CRKL/RELA/GSK3A/ILK/UBE2N/ACTN4/TAB2/CASP4/CAPN2/ITPR1/TRAF6/RPS6KB2/TAB1/HCLS1/PIK3R4/CYTH3/TECPR1/CBX3/CAPNS1/TRADD/MYL5/NFKBIB/TNIP1/ARPC3/CGAS/MAP3K7/PYCARD/VCL	1.33432454641911
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	19/1911	70/9376	1.33171862151454	AKT1/AKT2/PRKAG2/CAMKK2/STK11/PRKAB2/PTPN11/APPL1/MAPK10/G6PC3/CD36/RELA/ACSL3/RXRB/TRADD/NFKBIB/RXRA/STAT3/ACACB	1.40941348870933
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	9/1911	29/9376	1.52265468521626	TEAD1/CSNK1E/WTIP/RASSF4/YAP1/RASSF1/TEAD3/LATS1/PAK1	1.42619464412511
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	38/1911	155/9376	1.2028426258841	RAB5C/ATP6V0D1/RAB5A/ATP6V1A/STX12/CTSS/HLA-F/DYNC1LI2/ITGA5/ATP6V1C1/TUBA1C/FCGR2A/CD36/MRC2/PLA2R1/SEC22B/ITGAV/ATP6V1H/HGS/TUBA4A/CYBB/DYNC2H1/COLEC12/THBS3/NCF2/RAB7B/PIKFYVE/NCF1/MRC1/THBS2/COLEC11/DYNC1I2/TUBB6/ATP6V1E1/HLA-DPA1/RILP/EEA1/CYBA	1.28835971844542
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	29/1911	115/9376	1.2372488794849	CREB3L1/PRKACA/ITPR2/MEF2D/GNAQ/ADCY3/CREB3L2/MEF2A/STK39/SP1/FGFR1/GNA11/CDKN1A/MAPK1/CREB1/PRKCA/CREB3/ATF6B/GNAI3/CREB5/RAF1/ITPR1/PDE4D/ADCY9/RXRB/ARAF/RXRA/BRAF/PDE4A	1.29516536983919
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	33/1911	133/9376	1.21736051274182	CREB3L1/PPP3CA/PRKACA/AKT1/AKT2/ITPR2/PPP2R2A/PPP2CB/PPP2R2D/GNAQ/PPP1CC/GNB1/CREB3L2/PPP3CB/PPP2R5C/CACNA1C/PPP1CA/CREB1/MAPK10/PPP2R5D/PRKCA/CREB3/GSK3A/GNB2/ATF6B/PPP2R1B/GNAI3/CREB5/CALM3/ITPR1/CAMK2D/PPP2R3C/GRIA3	1.27732399181501
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	25/1911	98/9376	1.25161524578434	CREB3L1/ATP2B1/PRKACA/ITPR2/GNAQ/ADCY3/CREB3L2/ATP1B1/CACNA1C/GNA11/CREB1/PRKCA/CREB3/ATF6B/ATP1A1/CREB5/LDLR/CALM3/ITPR1/CAMK2D/STAR/ORAI1/ADCY9/NR4A1/CYP11A1	1.26684616668856
Genetic Information Processing	Transcription	hsa03040	Spliceosome	57/1911	243/9376	1.15086794451874	CDC40/RBM17/THOC7/AQR/CWC25/THOC2/SNRNP200/CCDC12/RBMX/LSM7/SRSF4/SF3B2/BUD31/PUF60/PRPF6/MAGOHB/TCERG1/SNRNP27/SNRNP70/ALYREF/PLRG1/DDX42/TXNL4A/FUS/SYF2/SNRNP40/SF3A1/ACIN1/DHX16/THOC6/RP9/PRPF19/DHX8/SNRPD2/HNRNPA1/TRA2A/PPIE/DDX39B/SMNDC1/CASC3/LSM4/HNRNPM/SF3B5/SF1/NCBP1/SNRPC/SRSF1/SNIP1/PRPF18/CTNNBL1/U2AF2/THOC3/SNRPD3/PPIH/USP39/DHX38/YJU2	1.20557562076726
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	41/1911	170/9376	1.18329177824976	MYH10/PRKACA/RAP1A/PPP2R2A/PPP2CB/PRKAG2/STK11/PPP2R2D/ARPC5L/ACTN1/MPDZ/RAB8A/PRKAB2/PARD3/SYMPK/CDK4/DLG1/ROCK1/HSPA4/TUBA1C/MAPK10/ARHGAP17/ACTR2/ARHGEF2/MAGI1/CCND1/MAP2K7/RDX/ACTN4/MYL6B/PPP2R1B/TUBA4A/HCLS1/RAP2C/SCRIB/ERBB2/MYH9/TJP1/AMOTL2/ARPC3/NEDD4	1.22020566167475
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1911	51/9376	1.34683617036558	PRKACA/ATP6V0D1/PLCG2/ATP6V1A/ADCY3/KDELR3/ATP6V1C1/PRKCA/ATP6V1H/ADCY9/SLC12A2/TJP1/ATP6V1E1/KDELR1	1.25656837634555
Organismal Systems	Immune system	hsa04611	Platelet activation	31/1911	126/9376	1.20711337037868	PRKACA/RAP1A/AKT1/AKT2/ITPR2/STIM1/GNAQ/PPP1CC/PLCG2/ADCY3/PPP1CA/MAPK1/COL1A1/PPP1R12A/ROCK1/PIK3CA/FCGR2A/GUCY1A1/FERMT3/SNAP23/GNAI3/ARHGAP35/PLA2G4C/COL3A1/ITPR1/ORAI1/ADCY9/P2RY1/FGB/COL1A2/MYLK	1.18419607676158
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1911	18/9376	1.63544392115821	ACSL3/ACACA/FASN/CBR4/MCAT/ACACB	1.36528411507186
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1911	60/9376	1.30835513692657	PPP3CA/AKT1/AKT2/PLCG2/MAP2K2/PPP3CB/BAD/PPP3R1/MAPK1/PIK3CA/PRKCA/KRAS/PLA2G4C/RAF1/HRAS/SPHK1	1.21230849596128
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1911	43/9376	1.36920886422548	ACAA2/ECHS1/ALDH7A1/ALDH9A1/ECI1/HADHB/ACAT2/ACAT1/ACSL3/ECI2/CPT2/ACADS	1.22771281731444
Human Diseases	Infectious disease: viral	hsa05162	Measles	33/1911	136/9376	1.19050697201958	AKT1/AKT2/ADAR/EIF2S1/BID/RCHY1/CDK4/CSNK2A1/BAD/CCND3/CDKN1B/BAX/IFNAR1/CDK6/PIK3CA/MAPK10/EIF3H/CCND1/IRF3/RELA/CSNK2A2/TAB2/FADD/CCND2/MAVS/TRAF6/FAS/TRADD/TYK2/NFKBIB/STAT3/JAK1/MAP3K7	1.13225805382666
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/1911	78/9376	1.25803378550631	BCAR1/CTNNB1/DOCK1/ARPC5L/CRK/DNM2/CBL/ITGA5/PIK3CA/ACTR2/CRKL/ILK/FN1/CAV2/ARHGAP10/RHOG/HCLS1/ARPC3/VCL/CAV1	1.15779102830102
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	36/1911	150/9376	1.17751962323391	HGF/AKT1/WNT2/AKT2/GRB2/MYC/CTNNB1/SOS2/RPS6KB1/FGF7/TGFBR2/MAP2K2/DVL3/APC/CDKN1B/BAX/CDKN1A/MAPK1/RB1/PIK3CA/CCND1/SMAD4/TGFB1/WNT5B/KRAS/RAF1/HRAS/RPS6KB2/RXRB/FZD1/ERBB2/ARAF/RXRA/TGFB2/MLH1/BRAF	1.10888458841334
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	46/1911	196/9376	1.15148602612159	PPP3CA/AKT1/AKT2/ITPR2/MYC/CTNNB1/RCAN1/PLCG2/CREBBP/GNB1/MAP2K2/ATG14/PPP3CB/BID/CDK4/HLA-F/BAX/MAP1LC3A/PPP3R1/CDKN1A/MAPK1/IFNAR1/RB1/CDK6/CREB1/PIK3CA/MAPK10/NFATC4/MAP2K4/CCND1/MAP2K7/IRF3/RELA/GNB2/HIF1A/FADD/KRAS/RAF1/HRAS/CALM3/ITPR1/FAS/TRADD/TYK2/STAT3/JAK1	1.08437711572586
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1911	19/9376	1.54936792530778	GCSH/DLD/DLAT/OGDH/PDHA1/DBT	1.21275440595146
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	19/1911	75/9376	1.24293738008024	CREB3L1/PRKACA/ITPR2/GNAQ/ADCY3/CREB3L2/ATP1B1/TTF2/CREB1/PRKCA/CREB3/ATF6B/ATP1A1/GPX3/CREB5/ITPR1/ADCY9/CGA/TTF1	1.06871333602422
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1911	62/9376	1.26615013250958	EIF4EBP2/PRKACA/AKT1/AKT2/FOXO3/PRKAG2/RPS6KB1/ADCY3/PRKAB2/PIK3CA/KRAS/IGF1/CAT/HRAS/RPS6KB2/ADCY9	1.06378898812083
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	50/1911	217/9376	1.1304911897407	CREB3L1/PRKACA/AKT1/AKT2/GRB2/MYC/SOS2/RPS6KB1/KPNB1/ADCY3/FGF7/CREB3L2/MAP2K2/CACNA1C/PAQR7/ESR1/BAD/CCND3/AIP/MAPK1/RB1/XIAP/KPNA4/GSTM5/CREB1/PIK3CA/CCND1/PRKCA/CREB3/RELA/GSTA4/ATF6B/RPS6KA3/KRAS/GNAI3/PGR/NOTCH2/EPHX1/CREB5/RAF1/HRAS/RPS6KB2/ADCY9/GSTM2/RXRB/PAQR8/AR/EIF4EBP1/RXRA/STAT3	0.98398415230329
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1911	89/9376	1.21280111007238	PRKACA/GRB2/ITPR2/SOS2/GNAQ/ADCY3/MAP2K2/GNA11/MAPK1/TUBA1C/GUCY1A1/PRKCA/KRAS/GNAI3/TUBA4A/RAF1/HRAS/ITPR1/ADCY9/TJP1/PDGFRB/TUBB6	1.02054520225288
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	27/1911	112/9376	1.1827764072662	AKT1/AKT2/LAMB1/BAD/MAP2K3/MAPK1/XIAP/SOCS1/MAPK10/LAMA2/RELA/LAMC1/TGFB1/IFNGR2/TAB2/GNAI3/LAMA4/LDLR/TRAF6/TAB1/TYK2/NFKBIB/STAT3/JAK1/TGFB2/HLA-DPA1/MAP3K7	0.984534524864591
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/1911	28/9376	1.40180907527846	ACAA2/ECHS1/ELOVL5/HADHB/TECR/ACOT7/HACD4/HACD1	1.07730947876625
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	35/1911	149/9376	1.15249403840008	PRKACA/NDUFA11/NDUFA13/MT-ND6/ITPR2/NDUFA9/GNAQ/NDUFA2/GNB1/ADCY3/NDUFS6/NDUFB5/CACNA1C/NDUFB10/NDUFB6/NDUFB7/NDUFV1/NDUFS1/NDUFS7/MAPK1/MAPK10/GABRE/PRKCA/NDUFS8/NDUFB1/GNB2/NDUFA3/GNAI3/NDUFS2/ITPR1/ADCY9/GRIA3/CNR1/NDUFA1/NDUFV2	0.949329147444558
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	46/1911	200/9376	1.12845630559916	MYH10/ARF6/ARPC5L/CYFIP1/MYO1C/PAK3/PTPN11/SEC24D/ABL1/BAX/WIPF2/MAPK1/ROCK1/TUBA1C/NCKAP1/MAPK10/SEC24B/ACTR2/FCGR2A/ARHGEF2/RELA/PAK2/TAB2/FADD/CASP4/MYO1B/TUBA4A/MYO6/TRAF6/WASF3/TAB1/HCLS1/CYTH3/PAK1/PTPN6/MYH9/TJP1/FAS/TRADD/NFKBIB/TUBB6/ARPC3/BRK1/MAP3K7/SEC24C/PYCARD	0.929062217093595
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/1911	63/9376	1.24605251135863	XPA/POLE3/DDB1/POLR2E/POLR2G/RAD23A/POLR2I/POLR2B/POLR2D/GTF2H3/CCNH/RAD23B/UVSSA/POLD2/ERCC4/CDK7	0.991412410285627
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1911	24/9376	1.43101343101343	EXT1/EXTL2/HS6ST1/HS2ST1/B3GALT6/NDST1/B4GALT7	1.06965875733609
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/1911	50/9376	1.2756462585034	ALDH7A1/ALDH9A1/PYCR2/SMS/SRM/PYCR3/GOT2/P4HA1/PYCR1/GAMT/ODC1/SAT2/L3HYPDH	0.988759056086526
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/1911	20/9376	1.47189952904239	CYP51A1/MSMO1/SQLE/LIPA/LBR/LSS	1.0688592275088
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1911	20/9376	1.47189952904239	GMPPA/CMAS/UAP1/CYB5R4/CYB5R3/GMPPB	1.0688592275088
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1911	12/9376	1.63544392115821	COQ7/COQ6/COQ5/COQ4	1.11439261574051
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	25/1911	105/9376	1.16817422939872	PPP3CA/AKT1/NFKB2/AKT2/ITPR2/PLCG2/PPP3CB/MDM2/LSP1/PTPN11/PPP3R1/RELB/MAPK1/PIK3CA/MAPK10/NFATC4/RELA/KRAS/RAF1/HRAS/CALM3/ITPR1/CARD9/PAK1/PYCARD	0.876782516252875
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	19/1911	78/9376	1.195132096231	MTMR6/INPP5A/PTEN/PLCG2/PI4KB/PIP5K1C/PIK3C2A/IP6K2/PIK3CA/ITPKC/IMPA1/PI4K2A/MTMR2/PI4KA/INPP5B/INPP4A/PIKFYVE/SACM1L/IPPK	0.875552749445254
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/1911	78/9376	1.195132096231	MAPK1/FCGR2A/ITGA4/RELA/TGFB1/IFNGR2/TAB2/CYBB/TRAF6/TAB1/NCF2/NCF1/PTPN6/NFKBIB/JAK1/TGFB2/HLA-DPA1/MAP3K7/CYBA	0.875552749445254
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	17/1911	69/9376	1.20880637650824	AKT1/AKT2/GRB2/SOS2/PLCG2/MAP2K2/MAP2K3/MAPK1/PIK3CA/MAPK10/MAP2K4/PRKCA/MAP2K7/KRAS/PLA2G4C/RAF1/HRAS	0.880774071148901
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1911	69/9376	1.20880637650824	CREB3L1/PPP3CA/PRKACA/PPP1CC/CREB3L2/PPP3CB/CACNA1C/PPP1CA/PPP3R1/CREB1/PRKCA/CREB3/ATF6B/CREB5/CALM3/CAMK2D/GRIA3	0.880774071148901
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	24/1911	101/9376	1.16586101310288	CREB3L1/PRKACA/WNT2/CTNNB1/GNAQ/CREBBP/ADCY3/CREB3L2/MAP2K2/DVL3/MAPK1/CREB1/PRKCA/CREB3/WNT5B/KRAS/GNAI3/KITLG/RAF1/HRAS/CALM3/CAMK2D/ADCY9/FZD1	0.847908750467211
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	36/1911	157/9376	1.12501874831265	RAB5C/ADAM17/BCAR1/RAB5A/DOCK1/PBX1/NR1H2/ATP11B/CRK/MAP2K2/GAS6/PTPN11/TMEM30A/MAPK1/UQCRFS1/CREB1/NFATC4/VPS33A/CRKL/CD36/TGFB1/ITGAV/HIF1A/LIPA/LRP1/GULP1/SPHK1/CAMK2D/PLA2G15/RAB7B/STAB1/PTPN6/ODC1/VPS16/EPOR/RXRA	0.799252752976902
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	32/1911	139/9376	1.12951522612365	CREB3L1/PRKACA/EBAG9/AKT1/AKT2/GRB2/ITPR2/SOS2/GNAQ/ADCY3/CREB3L2/MAP2K2/ESR1/SP1/MAPK1/CREB1/PIK3CA/CREB3/KRT18/ATF6B/KRAS/GNAI3/PGR/GABBR1/CREB5/RAF1/HRAS/FKBP4/CALM3/ITPR1/ADCY9/FKBP5	0.778330110930592
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	33/1911	144/9376	1.12436769579627	ALDH7A1/AKT1/AKT2/ALDH9A1/CTNNB1/FOXO3/PRKAG2/CAMKK2/PRKAB2/C5AR1/MAP2K3/MAPK10/MAP2K4/SREBF1/CCND1/MAP2K7/IRF3/IL17RA/RELA/TRA2A/TAB2/FADD/LPIN2/TRAF6/ACACA/FASN/TAB1/MLYCD/FAS/TRADD/C2/MAP3K7/ACACB	0.760925278486082
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1911	30/9376	1.30835513692657	ATIC/ABCC3/SHMT2/RELA/GART/MTR/DHFR2/ABCC4	0.855854626149307
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	24/1911	103/9376	1.14322293517855	COL6A2/COL15A1/COL6A1/COL5A1/DPP4/COL14A1/ATP1B1/SLC1A5/COL1A1/COL16A1/COL5A3/COL4A4/COL4A5/ATP1A1/COL5A2/PRCP/COL3A1/COL4A2/SLC8A1/SLC36A1/COL1A2/COL4A1/COL7A1/COL12A1	0.739472670566911
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1911	13/9376	1.50964054260758	XRCC6/POLL/POLM/XRCC4	0.93031325672078
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	23/1911	99/9376	1.13985485414057	CACNA2D1/SGCE/SNTB2/PRKAG2/DAG1/PRKAB2/CACNA1C/SSPN/ITGA5/LAMA2/SNTB1/ITGA4/LMNA/TGFB1/ITGAV/IGF1/EMD/ITGA3/SLC8A1/DES/SGCD/CACNB3/TGFB2	0.707770470880918
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/1911	67/9376	1.17166131665066	ALDH3B1/ALDH7A1/ALDH9A1/PFKL/AKR1A1/DLD/DLAT/ALDOA/GPI/LDHB/HK1/G6PC3/PDHA1/BPGM/PFKM/PGM1	0.713443197059538
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1911	49/9376	1.20155063595297	RFNG/GALNT13/B4GALT2/POFUT2/COLGALT1/GALNT2/POFUT1/GALNT11/PLOD3/GXYLT2/LFNG/FUT11	0.715669155690516
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/1911	49/9376	1.20155063595297	CREB3L1/PRKACA/GPSM1/CREB3L2/CREB1/CDK5/CREB3/RELA/ATF6B/GNAI3/CREB5/DLG4	0.715669155690516
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/1911	31/9376	1.26615013250958	ECHS1/ALDH3B1/ALDH7A1/ALDH9A1/ABAT/CSAD/MLYCD/ACADS	0.750963720502361
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	20/1911	86/9376	1.14100738685456	CACNA2D1/CTNNB1/SGCE/SNTB2/DAG1/CACNA1C/SSPN/ITGA5/LAMA2/SNTB1/ITGA4/LMNA/ITGAV/EMD/ITGA3/SLC8A1/DES/SGCD/CACNB3/CDH2	0.664636684872494
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	24/1911	105/9376	1.12144726022277	PRKACA/CACNA2D1/SGCE/SNTB2/DAG1/ADCY3/CACNA1C/SSPN/ITGA5/LAMA2/SNTB1/ITGA4/LMNA/TGFB1/ITGAV/IGF1/EMD/ADCY9/ITGA3/SLC8A1/DES/SGCD/CACNB3/TGFB2	0.633169747772005
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/1911	27/9376	1.27201193867861	ECHS1/HMGCS1/ACAT2/ABAT/ACAT1/ALDH5A1/ACADS	0.716124189357042
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1911	27/9376	1.27201193867861	ELOVL5/TECR/FADS2/ACOT7/HACD4/HACD1/FADS1	0.716124189357042
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/1911	59/9376	1.16421431675669	GCLM/G6PD/PGD/TXNDC12/IDH2/SMS/SRM/GSTM5/GGCT/GSTA4/IDH1/GPX3/GSTM2/ODC1	0.640176977175733
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	40/1911	181/9376	1.08427221292257	PPP3CA/RAB5C/AKT1/RFXANK/AKT2/ATP6V0D1/RAB5A/CREBBP/PPP3CB/LSP1/BID/CTSS/BAD/BAX/PPP3R1/MAPK1/CREB1/MAPK10/FCGR2A/MRC2/RELA/PLA2R1/TGFB1/IFNGR2/FADD/ATP6V1H/RAF1/SPHK1/CALM3/CAMK2D/CARD9/TRAF6/ITGAX/MRC1/TRADD/NFYB/JAK1/TGFB2/HLA-DPA1/EEA1	0.579227129172441
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1911	41/9376	1.1966662837743	GCSH/ALDH7A1/GRHPR/DLD/SHMT2/SRR/BPGM/DMGDH/GAMT/SDSL	0.638507134488081
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1911	78/9376	1.13223040695568	ZCCHC7/PAN3/PFKL/EXOSC6/LSM7/PABPC4/EDC3/XRN1/EXOSC1/DIS3L/LSM4/PATL1/PFKM/EXOSC5/DCPS/TENT4A/CNOT9/CNOT1	0.593314470589492
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	37/1911	168/9376	1.08056116219382	CSF3R/AOX1/STAT6/AKT1/AKT2/GRB2/MYC/SOS2/CREBBP/PIAS4/PTPN11/CCND3/CDKN1A/IFNAR1/SOCS1/FHL1/PIK3CA/CCND1/IL15/STAM2/IFNGR2/SOCS4/CCND2/RAF1/HRAS/PIAS3/CISH/CSH1/GHR/PTPN6/CTF1/PDGFRB/TYK2/EPOR/PIM1/STAT3/JAK1	0.533087849706594
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1911	116/9376	1.09969505043397	RAP1A/BCAR1/ARHGAP5/CTNNB1/CTNND1/PLCG2/ACTN1/CD99L2/PTPN11/ROCK1/VCAM1/PIK3CA/CXCR4/ITGA4/PRKCA/ACTN4/CD99/GNAI3/ARHGAP35/CYBB/NCF2/NCF1/CXCL12/MYL5/VCL/CYBA	0.54663593025558
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	34/1911	154/9376	1.08321610362427	GMPPA/GCLM/PANK3/PANK2/NME3/PMM2/NME4/GUSB/PDXK/RDH11/AKR1A1/DLD/COQ7/QPRT/UROS/NME6/COX15/SHMT2/COQ6/NME1/NADK/MTHFD1L/PMM1/DHFR2/MAT2B/AK9/COQ5/NADSYN1/COX10/FECH/BCAT2/COQ4/RFK/GMPPB	0.52681272225857
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1911	154/9376	1.08321610362427	CREB3L1/ATP2B1/PRKACA/CACNA2D1/AKT1/AKT2/PPP2R2A/PPP2CB/PPP2R2D/GNAQ/PPP1CC/ADCY3/CREB3L2/PPP2R5C/ATP1B1/CACNA1C/PPP1CA/MAPK1/SLC9A1/CREB1/PPP2R5D/PRKCA/CREB3/ATF6B/ATP1A1/PPP2R1B/GNAI3/CREB5/CALM3/CAMK2D/PPP2R3C/ADCY9/SLC8A1/CACNB3	0.52681272225857
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	47/1911	216/9376	1.06758144853383	PPP3CA/RAP1A/AKT1/AKT2/EIF2S1/PPP3CB/BID/POU2F1/CCL2/BAD/BAX/PPP3R1/MAP2K3/MAPK1/VCAM1/HSPA4/PIK3CA/MAPK10/MAP2K4/PRKCA/MAP2K7/IRF3/CD36/RELA/TAB2/KRAS/TANK/LDLR/HRAS/CALM3/ITPR1/CASP6/CAMK2D/CYBB/TRAF6/DDIT3/TAB1/NCF2/RXRB/NCF1/FAS/MIB2/RXRA/STAT3/MAP3K7/PYCARD/CYBA	0.508402538782411
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1911	10/9376	1.47189952904239	SQOR/MPST/SUOX	0.755394020752084
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1911	42/9376	1.16817422939872	GCLM/PCBP2/VDAC3/PRNP/MAP1LC3A/ACSL3/ATG7/CYBB/SAT2/SLC11A2	0.5526513929254
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	23/1911	103/9376	1.09558864621278	AKT1/AKT2/PPP2R2A/PPP2CB/PPP2R2D/GNAQ/TGFBR2/CCL2/GNA11/MAPK1/PIK3CA/MAPK10/MAP2K4/RELA/TGFB1/IFNGR2/FADD/PPP2R1B/GNAI3/TRAF6/FAS/CFLAR/TGFB2	0.493532627317812
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1911	15/9376	1.30835513692657	HEXA/ST6GALNAC4/GLB1/HEXB	0.604695546908521
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1911	104/9376	1.08505413999919	MBOAT7/PCYT1A/GPAT4/SGMS1/PTDSS1/LPGAT1/PLA2G12A/AGPAT5/PLPP5/PLD3/SGMS2/DGKD/GDPD5/PCYT2/AGPAT2/LYPLA2/LPCAT1/PGS1/PLA2G4C/LPIN2/PLA2G15/DGKZ/SAMD8	0.441292444229601
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	28/1911	128/9376	1.07326007326007	ATIC/NME3/IMPDH2/NME4/NT5C/ADCY3/AMPD2/ADK/NME6/GUCY1A1/NME1/GMPR2/APRT/ENTPD4/GART/NUDT9/PAICS/PDE4D/AK9/PDE10A/PRPS1/ADCY9/ENTPD3/ADA/AMPD3/PGM1/LACC1/PDE4A	0.422230399913844
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	25/1911	115/9376	1.06659386162492	CREB3L1/PRKACA/AKT1/AKT2/ITPR2/GNAQ/GNB1/ADCY3/CREB3L2/CACNA1C/GNA11/MAPK1/CREB1/PIK3CA/KCNQ3/PRKCA/CREB3/GNB2/KRAS/GNAI3/CREB5/HRAS/ITPR1/CAMK2D/ADCY9	0.363542553320863
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	37/1911	173/9376	1.04933107080093	AKT1/AKT2/ADAR/HNRNPUL1/CREBBP/EIF2S1/MAP2K2/BID/CCL2/CDK4/CCND3/BAX/PML/MAPK1/IFNAR1/CDK6/PIK3CA/FDPS/RAB11B/SLC25A6/PRKCA/IRF3/RELA/IFNGR2/FADD/MAVS/PABPN1/RAF1/RAE1/FAS/TRADD/TYK2/NFKBIB/JAK1/HLA-DPA1/NXF1/PYCARD	0.331344647000829
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1911	21/9376	1.16817422939872	PANK3/PANK2/AASDHPPT/CSAD/BCAT2	0.39034468786291
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/1911	50/9376	1.07939298796442	HGF/CCL2/GYPC/VCAM1/CD36/TGFB1/LRP1/THBS3/THBS2/TGFB2/SDC2	0.284787235153481
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1911	36/9376	1.0902959474388	AGL/GPI/HK1/G6PC3/PYGM/PYGL/PGM1/GAA	0.274629475330673
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1911	65/9376	1.0567483798253	ALDH7A1/PNPLA2/ALDH9A1/GPAT4/DGAT1/AKR1B1/AKR1A1/AGPAT5/PLPP5/DGKD/AGPAT2/GK/LPIN2/DGKZ	0.23228066331658
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	39/1911	187/9376	1.02324566190112	TP53BP1/TXN2/ITPR2/SHARPIN/PKN2/PKN1/VDAC3/CCL2/ANTXR2/MAP1LC3A/DNM1L/MAPK1/IFNAR1/XIAP/MAPK10/GSDMD/IRF3/MFN2/RELA/SUGT1/TAB2/FADD/CASP4/MAVS/TANK/NLRP1/ITPR1/CYBB/CARD9/TRAF6/TAB1/GPSM3/TRPV2/TYK2/NFKBIB/JAK1/MAP3K7/PYCARD/CYBA	0.162453723533275
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1911	17/9376	1.1544310031705	KYAT3/SEPHS2/MTR/SEPSECS	0.322437321907277
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1911	17/9376	1.1544310031705	MYH10/DAG1/NRP2/MYH9	0.322437321907277
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	44/1911	212/9376	1.01829527166454	HGF/RAP1A/EVL/AKT1/BCAR1/AKT2/CTNNB1/CTNND1/GNAQ/ADCY3/FGF7/CRK/MAP2K2/ENAH/PARD3/FGFR1/KRIT1/MAP2K3/MAPK1/PIK3CA/MAGI1/PRKCA/CRKL/KRAS/IGF1/GNAI3/RAPGEF1/KITLG/RAF1/HRAS/CALM3/SIPA1L1/ADCY9/P2RY1/VEGFC/FYB1/EFNA5/RALGDS/FLT1/FPR1/CNR1/PDGFRB/CSF1/BRAF	0.136321805229035
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1911	22/9376	1.11507540078969	ALDH3B1/ALDH7A1/ALDH9A1/CARNMT1/HNMT	0.273398564203401
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	22/1911	105/9376	1.02799332187087	ERC1/UBE2I/NFKB2/PLCG2/PLAU/PIAS4/CSNK2A1/LTBR/RELB/VCAM1/XIAP/ATM/RELA/CSNK2A2/TAB2/TRAF6/TAB1/PIDD1/CXCL12/TRADD/CFLAR/MAP3K7	0.145944210810265
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	31/1911	149/9376	1.0207804340115	AKT1/AKT2/GRB2/ARF6/SOS2/PLCG2/ADCY3/MAP2K2/TSC1/AVPR1A/DNM2/AGPAT5/PTPN11/PIP5K1C/MAPK1/PIK3CA/DGKD/PRKCA/AGPAT2/KRAS/KITLG/PLA2G4C/RAF1/HRAS/SPHK1/ADCY9/CXCR2/CYTH3/RALGDS/DGKZ/PDGFRB	0.129365527404469
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1911	32/9376	1.07326007326007	PPP2CB/ATG4B/ATG4A/ATG7/PIK3R4/ATG13/ATG2B	0.210027904144738
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1911	32/9376	1.07326007326007	HTRA2/BIRC6/BID/BAX/XIAP/MAPK10/FADD	0.210027904144738
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1911	37/9376	1.06082848939992	GLS/ASS1/ABAT/ASL/ALDH5A1/GOT2/GFPT2/GFPT1	0.187568014606287
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1911	42/9376	1.05135680645885	ECHS1/AOX1/ALDH7A1/ALDH9A1/ACAT2/DLD/ACAT1/KYAT3/CAT	0.168767894624278
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/1911	91/9376	1.02439893962657	PPP3CA/AKT1/AKT2/GRB2/SOS2/PLCG2/MAP2K2/PPP3CB/PPP3R1/MAPK1/PIK3CA/RELA/KRAS/IFITM1/RAF1/HRAS/DAPP1/PTPN6/NFKBIB	0.118331881574218
Cellular Processes	Cell motility	hsa04814	Motor proteins	40/1911	194/9376	1.01161479659271	MYH10/MYO9B/DCTN1/KIF22/KIF3B/ACTA2/HOOK3/KIF26B/MYO1C/ACTR1B/ACTR1A/DYNLL2/ACTR10/DYNC1LI2/KIF16B/KIF13A/MYO9A/TUBA1C/DNAH14/KIF9/MYO19/MYL6B/DCTN3/KLC1/MYO1B/DYNLRB1/DCTN2/TUBA4A/KIF3A/MYO6/KIF13B/DYNC2H1/DNAL1/MYO18A/MYH9/DYNLT3/MYL5/DYNC1I2/TUBB6/CAPZB	0.0827075021608893
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1911	72/9376	1.02215245072388	ADAR/PIN1/OTUD5/AZI2/ZNFX1/MAPK10/IRF3/RELA/FADD/MAVS/TANK/TRAF6/TRADD/NFKBIB/MAP3K7	0.095467214749585
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1911	18/9376	1.0902959474388	LMBRD1/MTR/ABCD4/PRDX1	0.194005511090365
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1911	97/9376	1.01161479659271	PRKACA/GNAQ/GNB1/ADCY3/CACNA1C/MAPK1/CREB1/PER3/NOS1AP/GUCY1A1/PRKCA/GNB2/GNAI3/CALM3/ITPR1/CAMK2D/ADCY9/GRIA3/RASD1/PER1	0.0581765501250802
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1911	23/9376	1.06659386162492	LNPEP/THOP1/PRCP/NLN/CTSA	0.161779588305189
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1911	38/9376	1.03291195020518	AOX1/NT5C/SIRT2/QPRT/SIRT5/SIRT7/NADK/NADSYN1	0.102853614057461
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1911	83/9376	1.00491132504902	PEX2/IDH2/ACOT8/PEX3/PEX26/ACSL3/IDH1/PEX19/CAT/ECI2/PEX5/ABCD4/PEX11A/PEX14/MLYCD/NUDT19/PRDX1	0.0227384486656746
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	17/1911	83/9376	1.00491132504902	POLR3D/ADAR/POLR2E/POLR3A/POLR3GL/POLR1D/GSDME/GSDMD/IRF3/RELA/FADD/POLR3E/MAVS/NFKBIB/POLR3K/CGAS/PYCARD	0.0227384486656746
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1911	69/9376	0.995487604183256	PPP3CA/PRKACA/ITPR2/GNAQ/PPP3CB/CACNA1C/PPP3R1/CREB1/GUCY1A1/GNAI3/CALM3/ITPR1/ORAI1/KCNMA1	-0.0190339073959826
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1911	99/9376	0.991178134035277	PRKACA/ITPR2/GNAQ/PPP1CC/PLCG2/ADCY3/PPP1CA/MAP2K3/PIK3CA/MAPK10/PRKCA/IGF1/PLA2G4C/CALM3/ITPR1/IL1RAP/CAMK2D/ADCY9/NTRK1/TRPV2	-0.044645259303082
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/1911	109/9376	0.99026879629763	MAP3K8/AKT1/TOLLIP/AKT2/MAP2K2/MAP2K3/MAPK1/IFNAR1/PIK3CA/MAPK10/MAP2K4/MAP2K7/IRF3/RELA/TAB2/FADD/TRAF6/TAB1/TYK2/SPP1/JAK1/MAP3K7	-0.0517024718528592
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	48/1911	238/9376	0.989512288431856	PRKACA/HGF/RAB5C/RAP1A/AKT1/AKT2/GRB2/RAB5A/ARF6/SOS2/PLCG2/GNB1/FGF7/MAP2K2/RASA1/PLA2G12A/PAK3/FGFR1/BAD/PTPN11/ABL1/NF1/MAPK1/PIK3CA/MAPK10/PRKCA/RELA/GNB2/STK4/PAK2/KRAS/IGF1/RASSF1/KITLG/PLA2G4C/RAF1/HRAS/ETS1/CALM3/NTRK1/VEGFC/EFNA5/RALGDS/PAK1/FLT1/PDGFRB/RASA3/CSF1	-0.0829172160667836
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1911	70/9376	0.981266352694924	SGCE/SNTB2/DAG1/BID/SSPN/HLA-F/ABL1/LAMA2/SNTB1/CCND1/EIF4G3/SGCD/HLA-DPA1/CAV1	-0.079595939124388
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1911	86/9376	0.969856278826378	CREB3L1/PRKACA/GNAQ/ADCY3/CREB3L2/ATP1B1/CACNA1C/GNA11/CREB1/PRKCA/CREB3/ATF6B/ATP1A1/CREB5/CAMK2D/ADCY9/KCNMA1	-0.142082080644616
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1911	76/9376	0.968354953317359	PRKACA/ITPR2/GNAQ/ADCY3/ATP1B1/SLC9A1/PRKCA/ATP1A1/GNAI3/CALM3/ITPR1/CAMK2D/SLC4A2/ADCY9/MYLK	-0.140143234974034
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1911	71/9376	0.967445699840066	ADAM17/ATP6V0D1/PLCG2/ATP6V1A/PTPN11/ATP6V1C1/MAPK10/MAP2K4/RELA/ATP6V1H/CXCR2/PAK1/TJP1/ATP6V1E1	-0.1393094009842
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/1911	56/9376	0.963743739253943	NFKB2/BCL2L13/HSF1/VCP/RAB1B/HBS1L/RELA/SEC22B/SAR1A/CLK4/PYCARD	-0.137679774039949
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1911	46/9376	0.959934475462426	HEPH/GUSB/HCCS/UROS/COX15/BLVRA/FXN/COX10/FECH	-0.13781928819689
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1911	41/9376	0.957333027019438	NBN/RAD51B/ATM/RBBP8/TOPBP1/MUS81/UIMC1/POLD2	-0.138524845907824
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	38/1911	193/9376	0.966013507834381	PRKACA/RAP1A/AKT1/BCAR1/AKT2/GRB2/FOXO3/SOS2/GNAQ/PLCG2/GNB1/ADCY3/CRK/GRK6/PARD3/CCL2/BAD/MAPK1/ROCK1/PIK3CA/CXCR4/CRKL/RELA/GSK3A/GNB2/KRAS/GNAI3/RAF1/HRAS/ADCY9/CXCR2/GRK4/NCF1/PAK1/CXCL12/NFKBIB/STAT3/BRAF	-0.241375830060888
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1911	31/9376	0.949612599382185	SRP68/SRP19/TMEM208/BAG6/SRP54/UBL4A	-0.142172049578204
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1911	52/9376	0.943525339129735	PRKACA/ADCY3/IGF1/PLA2G4C/LDLR/STAR/ADCY9/HSD17B2/CGA/CYP11A1	-0.206611859689227
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/1911	109/9376	0.945256578284101	PPP3CA/STAT6/RORA/TGFBR2/PPP3CB/PPP3R1/MAPK1/MAPK10/SMAD4/RELA/TGFB1/IFNGR2/HIF1A/IL1RAP/RXRB/TYK2/NFKBIB/RXRA/STAT3/JAK1/HLA-DPA1	-0.290855099426814
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1911	37/9376	0.928224928224928	GNAQ/VCAM1/THOP1/PRKCA/APOL1/LAMA4/FAS	-0.221322407376635
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	44/1911	226/9376	0.955215033596829	CREB3L1/ATP2B1/PRKACA/RAP1A/AKT1/AKT2/PPP1CC/CREBBP/ADCY3/CREB3L2/MAP2K2/ATP1B1/CACNA1C/PPP1CA/BAD/MAPK1/PPP1R12A/ROCK1/SLC9A1/CREB1/PIK3CA/MAPK10/GLI3/CREB3/RELA/ATP1A1/GNAI3/GABBR1/CREB5/RAF1/CALM3/CAMK2D/PDE4D/PDE10A/ORAI1/ADCY9/CGA/GRIA3/PAK1/ABCC4/FXYD1/BRAF/PDE4A/OXTR	-0.344807736023411
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1911	16/9376	0.919937205651491	ALDH3B1/MIF/GOT2	-0.162163790198205
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1911	16/9376	0.919937205651491	HEXA/NAGA/HEXB	-0.162163790198205
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/1911	43/9376	0.91280590948365	DGAT1/ACAT2/PLA2G12A/ACAT1/GOT2/SLC27A1/CD36/AGPAT2	-0.289942395466494
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1911	38/9376	0.903797956429535	ATP1B1/MAPK1/PIK3CA/PRKCA/ATP1A1/KRAS/IGF1	-0.300642404939509
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1911	17/9376	0.865823252377874	ACOT8/CYP7B1/HSD3B7	-0.280148352839111
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1911	23/9376	0.853275089299934	GLS/ASS1/ASL/GOT2	-0.356445700369034
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1911	23/9376	0.853275089299934	B4GALT2/RXYLT1/POMGNT2/B4GAT1	-0.356445700369034
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1911	82/9376	0.897499712830723	NME3/IMPDH2/NME4/GUSB/DUT/GSTM5/NME6/TK2/NME1/GSTA4/TYMP/UCK2/UPP1/GSTM2/CES2	-0.471662935882635
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1911	61/9376	0.884748350790505	ATP2B1/SLC26A6/HEPH/ATP1B1/ATOX1/SLC31A1/ATP1A1/MT1X/SLC8A1/SLC39A4/SLC11A2	-0.456900583082686
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1911	93/9376	0.896856343860952	ATP2B1/PRKACA/ITPR2/GNAQ/ADCY3/ATP1B1/SLC9A1/GUCY1A1/PRH1/PRKCA/ATP1A1/CALM3/ITPR1/SLC4A2/ADCY9/SLC12A2/KCNMA1	-0.50575582864534
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	31/1911	168/9376	0.905335027784007	STAT6/CHMP4A/SHARPIN/CHMP1B/VPS4A/VDAC3/CAPN1/BID/BAX/DNM1L/IFNAR1/XIAP/MAPK10/SLC25A6/IFNGR2/CHMP2A/VPS4B/FADD/CAPN2/PLA2G4C/CAMK2D/CYBB/PYGM/PYGL/FAS/TRADD/TYK2/CFLAR/STAT3/JAK1/PYCARD	-0.626415323549442
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1911	116/9376	0.888215233042819	PPP3CA/PRKACA/ITPR2/GLS/GNAQ/HOMER3/GNB1/ADCY3/PPP3CB/CACNA1C/PPP3R1/MAPK1/PRKCA/TRPC1/GNB2/GNAI3/PLA2G4C/ITPR1/ADCY9/GRIA3/DLG4	-0.612924812295623
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1911	36/9376	0.817721960579103	GUSB/AKR1B1/AKR1A1/RPE/DCXR/CRYL1	-0.554387253806607
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	24/1911	133/9376	0.885353100175871	PPP3CA/GRB2/SOS2/PLCG2/MAP2K2/PPP3CB/BID/PTPN11/PPP3R1/MAPK1/IFNAR1/PIK3CA/PRKCA/IFNGR2/KRAS/TYROBP/RAF1/HRAS/RAET1G/PAK1/PTPN6/FAS/ARAF/BRAF	-0.673725111729523
NA	NA	hsa04981	Folate transport and metabolism	5/1911	31/9376	0.791343832818487	ABCC3/SHMT2/MTR/DHFR2/ABCC4	-0.588739934618487
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1911	102/9376	0.865823252377874	ATP2B1/RAP1A/ITPR2/GNAQ/ADCY3/RAB8A/ATP1B1/PLA2G12A/SLC9A1/PRKCA/TRPC1/ATP1A1/ITPR1/SLC4A2/ADCY9/SLC12A2/KCNMA1/RAB27B	-0.689358089587385
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1911	48/9376	0.817721960579103	CHMP4A/CHMP1B/DPP4/VPS4A/HSPG2/VPS4B/LDLR/TGOLN2	-0.640562889201082
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1911	37/9376	0.795621367049938	AOX1/ALDH3B1/MIF/GOT2/FAHD1/FAH	-0.630212829359557
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1911	54/9376	0.817721960579103	USP1/TELO2/REV3L/HES1/ATRIP/MUS81/FAN1/ERCC4/MLH1	-0.679638159281623
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1911	87/9376	0.84591926956459	CACNA2D1/UQCRC1/ATP1B1/CACNA1C/UQCRFS1/UQCR11/SLC9A1/UQCRH/UQCRQ/ASPH/ATP1A1/COX6B1/SLC8A1/CACNB3/COX7A1	-0.730507281410875
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1911	14/9376	0.700904537639231	FUT8/B4GALT2	-0.566618303502808
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	15/1911	89/9376	0.826909847776621	PRKACA/GLS/GNB1/ADCY3/CACNA1C/ABAT/PLCL1/GABRE/PRKCA/GNB2/GNAI3/TRAK2/GABBR1/ADCY9/SLC38A5	-0.830100577711783
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	46/1911	254/9376	0.888548272125325	ATP2B1/PPP3CA/PRKACA/HGF/ITPR2/STIM1/GNAQ/PLCG2/ADCY3/FGF7/VDAC3/PPP3CB/CACNA1C/AVPR1A/ORAI2/FGFR1/GNA11/PPP3R1/NFATC4/ITPKC/SLC25A6/CXCR4/TPCN1/PRKCA/ORAI3/ASPH/MCOLN1/PHKB/SPHK1/CALM3/ITPR1/STIM2/CAMK2D/TFEB/P2RX4/ORAI1/ADCY9/NTRK1/SLC8A1/VEGFC/FLT1/ERBB2/PDGFRB/MYLK/PHKG1/OXTR	-0.91108669804099
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1911	15/9376	0.654177568463283	THTPA/ACP1	-0.678170263208979
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/1911	79/9376	0.807371049685697	ATP6V0D1/NAPA/AP2A1/AP2B1/ATP6V1A/AP2S1/DNM2/ATP6V1C1/STX2/AP2M1/ATP6V1H/AP2A2/ATP6V1E1	-0.869890852415781
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1911	28/9376	0.700904537639231	AKR1B1/CBR1/DHFR2/PCBD2	-0.801919111543029
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1911	28/9376	0.700904537639231	ATP6V0D1/ATP6V1A/ATP6V1C1/ATP6V1E1	-0.801919111543029
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1911	63/9376	0.778782819599146	WNT2/CTNNB1/DVL3/APC/BAX/CDKN1A/GLI3/WNT5B/FZD1/BMP4	-0.891344115151643
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1911	47/9376	0.730730262645156	CACNA1C/MAPK1/HK1/SOCS1/PIK3CA/MAPK10/SOCS4	-0.936310739676697
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1911	59/9376	0.748423489343586	PRKACA/AKT1/PNPLA2/AKT2/ADCY3/PIK3CA/GNAI3/ADCY9/CGA	-0.980751820555748
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1911	23/9376	0.639956316974951	MSH3/POLD2/MLH1	-0.874670989043256
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1911	23/9376	0.639956316974951	GLS/ATP1B1/ATP1A1	-0.874670989043256
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/1911	93/9376	0.791343832818487	PPP3CA/STAT6/PPP3CB/MAML2/PPP3R1/MAPK1/MAPK10/RELA/IFNGR2/NOTCH2/NOTCH3/TYK2/NFKBIB/JAK1/HLA-DPA1	-1.02312712856119
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	58/1911	323/9376	0.881013133998539	UBE2I/GRB2/MYC/PTEN/SOS2/DNMT1/GLS/PLCG2/PLAU/CREBBP/CRK/MAP2K2/BCL2L2/APC/MDM2/RECK/ABL1/CDKN1B/PDCD4/DICER1/CDKN1A/ITGA5/MAPK1/ROCK1/MDM4/BMPR2/CDK6/SOCS1/PIK3CA/TNXB/ATM/ZEB1/CDKN2A/HDAC4/TNC/CCND1/PRKCA/CRKL/ZEB2/RDX/BMI1/KRAS/CCND2/FSCN1/NOTCH2/RASSF1/STMN1/RAF1/HRAS/FOXP1/NOTCH3/EFNA5/ERBB2/PDGFRB/PIM1/STAT3/TGFB2/DDIT4	-1.10104508465834
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1911	48/9376	0.715506715506716	AKT1/AKT2/ATP1B1/HK1/PIK3CA/G6PC3/ATP1A1	-0.999768490226761
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1911	36/9376	0.681434967149253	GALNT13/GALNT2/ST6GALNAC4/GALNT11/GCNT4	-0.968895618375247
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1911	31/9376	0.63307506625479	ALDH7A1/ALDH9A1/GUSB/AKR1A1	-1.03530781965877
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1911	50/9376	0.686886446886447	LTBR/CXCR4/ITGA4/IL15/TGFB1/CXCL12/HLA-DPA1	-1.12315640671261
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1911	91/9376	0.754820271303788	PRKACA/GNB1/ADCY3/GRK6/GABRE/PRKCA/GNB2/GNAI3/GABBR1/PDE4D/PDE10A/ADCY9/GRK4/PDE4A	-1.18909178286117
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1911	38/9376	0.645569968878239	PTPRC/UNG/RFXANK/ORAI1/ADA	-1.10763444293345
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1911	63/9376	0.700904537639231	PTGES2/PLA2G12A/CBR1/PTGR2/PTGIS/PTGR1/PLA2G4C/CBR3/LTA4H	-1.20513686939119
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1911	26/9376	0.566115203477841	FADS2/PLA2G12A/PLA2G4C	-1.12087291989546
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1911	76/9376	0.710126965766064	HMGCS1/FADS2/PLTP/SLC27A1/CD36/ILK/ACSL3/GK/CPT2/RXRB/RXRA	-1.28373154752106
NA	NA	hsa04519	Cadherin signaling	71/1911	404/9376	0.862251374274005	APH1A/EVL/WNT2/TEAD1/CTNNB1/CTNND1/ARPC5L/PPP1CC/RYK/CREBBP/ACTN1/LHFPL6/MAP2K2/ENAH/DVL3/APC/MPDZ/CYFIP1/PSENEN/PCDH10/CDH13/MYO1C/PPP1CA/ATN1/FGFR1/TAOK1/YWHAG/PRICKLE2/APH1B/MAP2K3/MAPK1/ROCK1/NCSTN/YWHAH/NCKAP1/MAPK10/PCDH18/ACTR2/PCDHGA10/WTIP/GABRE/TMC1/RELA/YAP1/ACTN4/KRT18/WNT5B/KRAS/MYO1B/TEAD3/LATS1/ARHGAP35/RAF1/HRAS/FAT1/VANGL1/PCDHGA12/CIB2/DES/FZD1/ERBB2/CDH2/TJP1/PDGFRB/AMOTL2/ARPC3/BRK1/VCL/KRT8/ABI2/LIMA1	-1.43197158595821
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/1911	95/9376	0.723038365143628	ATP6V0D1/ATP6V1A/CCL2/ATP6V1C1/IL15/TGFB1/ATP6V1H/CXCL12/FLT1/CSF1/ACP5/ATP6V1E1/TGFB2/HLA-DPA1	-1.3727299403812
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1911	78/9376	0.691918582028472	ITGA5/MAPK1/MAPK10/IRF3/RELA/GNAI3/CFL2/CALM3/TRAF6/C2/PYCARD	-1.38235348140084
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/1911	90/9376	0.708692365835223	PRKACA/ADCY3/ATP1B1/ABCC3/SLC9A1/ATP1A1/EPHX1/LDLR/HMGCR/SLC4A2/ADCY9/ABCC4/RXRA	-1.40494672693317
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/1911	115/9376	0.725283825904944	PRKACA/ITPR2/GNAQ/GNB1/CACNA1C/MAPK1/PRKCA/TRPC1/GNB2/KRAS/GNAI3/PLA2G4C/RAF1/HRAS/ITPR1/ARAF/BRAF	-1.49970307971578
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1911	44/9376	0.557537700394843	HLA-F/CPE/PTPRN/FAS/HLA-DPA1	-1.48838855224577
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1911	94/9376	0.678535243884788	ANAPC5/CCL2/MAPK1/MAPK10/IL17RA/RELA/ELAVL1/TAB2/FADD/SRSF1/TRAF6/TRADD/MAP3K7	-1.58481139917564
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1911	51/9376	0.577215501585249	PLA2G12A/PAFAH1B2/PLD3/LPCAT1/PLA2G4C/PAFAH1B1	-1.53172499326446
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/1911	160/9376	0.735949764521193	PTPRC/PVR/SDC4/CD99L2/HLA-F/GLG1/VSIR/NECTIN2/VCAM1/CD58/SELPLG/ITGA4/NFASC/ITGAV/CD99/NLGN2/NLGN4X/NECTIN3/CD276/CADM3/NEGR1/CDH2/HLA-DPA1/SDC2	-1.70441910306476
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	28/1911	183/9376	0.750695570367702	GTPBP4/NHP2/DKC1/WDR75/MDN1/NAT10/BMS1/UTP18/GNL2/CSNK2A1/XRN1/NOP56/WDR36/MPHOSPH10/POP7/POP5/FBL/HEATR1/UTP6/CSNK2A2/TCOF1/LSG1/NOP10/RPP25L/NOB1/GNL3L/NXF1/RIOK1	-1.72316944671405
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1911	66/9376	0.594706880421166	STAT6/RORA/RELA/TGFB1/IFNGR2/STAT3/TGFB2/HLA-DPA1	-1.67173499588907
Genetic Information Processing	Translation	hsa03010	Ribosome	34/1911	222/9376	0.751420179991608	MRPL21/RPS17/MRPS18C/RPS4Y1/RPL26L1/MRPL12/MRPL28/MRPL19/RPL17/MRPS18B/MRPL14/MRPL50/MRPS15/MRPS11/MRPS12/MRPS21/MRPL54/MRPS27/MRPL45/MRPL24/MRPL22/MRPL49/MRPL4/MRPL17/MRPL20/MRPL47/MRPS2/MRPS23/MRPL2/MRPL10/RPL31/RPL38/MRPL48/RPS20	-1.8964350706241
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1911	17/9376	0.288607750792625	CSAD	-1.48531970233189
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1911	26/9376	0.377410135651894	LMBRD1/ABCD4	-1.60836269153197
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/1911	88/9376	0.613291470434328	PLAU/C5AR1/F10/F13A1/VTN/A2M/SERPINE2/VSIG4/ITGAX/FGB/C2	-1.84401759124749
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/1911	82/9376	0.598333141887149	RFXANK/LGMN/CTSS/HLA-F/HSPA4/CREB1/PSME3/TAPBPL/NFYB/HLA-DPA1	-1.8483008660394
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1911	36/9376	0.408860980289552	POLE3/MCM3/POLD2	-1.79791234751253
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1911	28/9376	0.350452268819616	B4GALT2/ST3GAL4	-1.74153340669767
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	28/1911	195/9376	0.704498919883535	CLCN5/AKT1/AKT2/PLCG2/MAP2K2/VDAC3/HAT1/C5AR1/MAPK1/PIK3CA/SLC25A6/FCGR2A/SELPLG/HDAC4/GSDMD/PRKCA/RELA/CASP4/RAF1/ATG7/CYBB/NCF2/HDAC11/FGB/NCF1/FPR1/MAP3K7/CYBA	-2.10975711573604
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1911	29/9376	0.338367707825836	GNB1/CALM3	-1.80542996775887
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1911	45/9376	0.436118378975522	ABCB8/ABCC3/ABCD4/ABCC4	-1.91836471368703
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1911	30/9376	0.327088784231641	PLA2G12A/PLA2G4C	-1.86769769021314
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1911	39/9376	0.377410135651894	HLA-F/FAS/HLA-DPA1	-1.97120479072145
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	34/1911	238/9376	0.700904537639231	RPS17/ADAM17/RPS4Y1/ADAR/RPL26L1/NRP1/PLCG2/RPL17/C5AR1/CCL2/MAPK1/IFNAR1/PIK3CA/MAPK10/F13A1/FCGR2A/PRKCA/IRF3/RELA/TAB2/MAVS/CYBB/TRAF6/FGB/TYK2/NFKBIB/C2/RPL31/STAT3/JAK1/RPL38/CGAS/MAP3K7/RPS20	-2.36468775061402
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1911	191/9376	0.642190021397202	CREB3L1/PRKACA/GRB2/SOS2/CAMKK2/PPP1CC/GNB1/CREB3L2/HAT1/PPP1CA/MAPK1/CREB1/HDAC4/CREB3/GNB2/ATF6B/KRAS/GNAI3/CREB5/RAF1/HRAS/CALM3/HDAC11/ARAF/BRAF	-2.52772967504612
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1911	45/9376	0.327088784231641	HLA-F/FAS/HLA-DPA1	-2.28929102074462
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1911	26/9376	0.188705067825947	HES1	-2.09585246316848
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1911	54/9376	0.363431982479602	HLA-F/CGA/FAS/HLA-DPA1	-2.37349445418447
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1911	79/9376	0.434738257523068	ALDH3B1/CBR1/GSTM5/GSTA4/EPHX1/CBR3/GSTM2	-2.55265897570942
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1911	66/9376	0.371691800263229	STS/CYP7B1/HSD17B11/HSD17B2/CYP11A1	-2.591617658833
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1911	41/9376	0.23933325675486	GABRE/GRIA3	-2.46962078709554
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1911	68/9376	0.360759688490781	AOX1/PNPLA4/DGAT1/RDH11/CYP26B1	-2.67664946294398
Human Diseases	Immune disease	hsa05310	Asthma	1/1911	32/9376	0.153322867608582	HLA-DPA1	-2.42732249218705
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1911	100/9376	0.441569858712716	CSF3R/ITGA5/ITGA4/CD36/KITLG/ITGA3/CSF1/EPOR/HLA-DPA1	-2.84046575031919
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1911	70/9376	0.350452268819616	CBR1/GSTM5/GSTA4/EPHX1/GSTM2	-2.75981290922509
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1911	73/9376	0.336050120785933	AOX1/ALDH3B1/GSTM5/GSTA4/GSTM2	-2.88128548573343
NA	NA	hsa04081	Hormone signaling	26/1911	219/9376	0.58248687602895	PRKACA/HEPH/STK11/THRA/GNAQ/GNB1/ADCY3/AVPR1A/RAMP2/ESR1/GNA11/APPL1/PIK3CA/SMAD4/GNB2/ITGAV/IGF1/GNAI3/ACVR1/ADCY9/CSH1/GHR/CGA/EPOR/STAT3/OXTR	-3.1631272059543
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/1911	100/9376	0.39250654107797	CCL2/LTBR/CXCR4/TNFRSF10D/TNFRSF14/CXCR2/CXCL12/CSF1	-3.09002726757052
NA	NA	hsa04382	Cornified envelope formation	24/1911	217/9376	0.542635771075534	PPP2R2A/PPP2CB/PPP2R2D/KAZN/CAPN1/PPP2R5C/SPTLC1/SPTLC2/S100A3/PPP2R5D/SLC27A1/COL4A4/COL4A5/KRT18/PPP2R1B/PPP2R3C/FURIN/COL4A2/PCSK6/PPL/TJP1/COL4A1/COL7A1/KRT8	-3.44880872023911
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1911	99/9376	0.346912346912347	C5AR1/FCGR2A/SELPLG/KRT18/FPR1/C2/HLA-DPA1	-3.30511342343375
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1911	86/9376	0.228201477370913	PRKACA/CACNA1C/GABBR1/P2RY1	-3.63786339788543
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	31/1911	298/9376	0.510390217005749	CSF3R/TGFBR2/ACVRL1/GDF11/RELT/CCL2/LTBR/INHBB/TNFRSF21/IFNAR1/BMPR2/CXCR4/TNFRSF10D/IL17RA/IL15/TGFB1/IFNGR2/TNFRSF14/ACVR1/IL1RAP/BMP5/CSH1/CXCR2/GHR/CXCL12/BMP4/CTF1/FAS/CSF1/EPOR/TGFB2	-4.34574466298785
NA	NA	hsa04082	Neuroactive ligand signaling	16/1911	199/9376	0.394478935756753	PRKACA/GNAQ/GNB1/ADCY3/GNA11/GABRE/PRKCA/GNB2/GNAI3/P2RY14/GABBR1/OGFRL1/P2RX4/ADCY9/P2RY1/GRIA3	-4.36824012276393
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1911	143/9376	0.205860073991942	ACTN1/FCGR2A/ACTN4/SNRPD3/C2/HLA-DPA1	-4.84166467526205
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	21/1911	370/9376	0.278467478467478	S1PR3/THRA/AVPR1A/C5AR1/CALCRL/GABRE/TSPO/NR3C1/P2RY14/GABBR1/OGFRL1/P2RX4/CSH1/P2RY1/GHR/CGA/GRIA3/FPR1/CNR1/LYPD6/OXTR	-7.16459881971115
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1911	449/9376	0.0655634534094604	PRKACA/GNB1/ADCY3/CALM3/CAMK2D/SLC8A1	-10.2664735957174