ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0032182 ubiquitin-like protein binding 61/3948 120/18639 0.508333333333333 2.39990501519757 6.3226634057759e-13 8.41546499308772e-10 GO:0003712 transcription coregulator activity 166/3948 495/18639 0.335353535353535 1.583245832182 7.33260277817963e-11 4.87984714887854e-08 GO:0043130 ubiquitin binding 50/3948 100/18639 0.5 2.36056231003039 1.6081339903226e-10 7.13475447039795e-08 GO:0070063 RNA polymerase binding 34/3948 59/18639 0.576271186440678 2.72064808613673 1.09355987691496e-09 3.63882049043453e-07 GO:0031267 small GTPase binding 103/3948 283/18639 0.363957597173145 1.7182891726723 2.39023660259734e-09 6.36280983611412e-07 GO:0000993 RNA polymerase II complex binding 24/3948 36/18639 0.666666666666667 3.14741641337386 5.25813253312488e-09 1.16642906693154e-06 GO:0001098 basal transcription machinery binding 33/3948 60/18639 0.55 2.59661854103343 9.6425129663221e-09 1.22640085773507e-06 GO:0001099 basal RNA polymerase II transcription machinery binding 33/3948 60/18639 0.55 2.59661854103343 9.6425129663221e-09 1.22640085773507e-06 GO:0019787 ubiquitin-like protein transferase activity 154/3948 479/18639 0.321503131524008 1.51785634966464 9.69653611232186e-09 1.22640085773507e-06 GO:0051020 GTPase binding 110/3948 315/18639 0.349206349206349 1.64864669271964 1.00191482985094e-08 1.22640085773507e-06 GO:0042393 histone binding 91/3948 247/18639 0.368421052631579 1.73936170212766 1.01355442788023e-08 1.22640085773507e-06 GO:0043175 RNA polymerase core enzyme binding 26/3948 42/18639 0.619047619047619 2.92260095527573 1.24878759333076e-08 1.38511357226937e-06 GO:0140297 DNA-binding transcription factor binding 155/3948 488/18639 0.317622950819672 1.49953753301111 2.14985394369371e-08 2.20111969158179e-06 GO:0045296 cadherin binding 114/3948 334/18639 0.341317365269461 1.61140181642793 2.31594934096184e-08 2.20180612344301e-06 GO:0016755 aminoacyltransferase activity 155/3948 496/18639 0.3125 1.475351443769 6.98595789015942e-08 6.19887330120146e-06 GO:0003713 transcription coactivator activity 90/3948 256/18639 0.3515625 1.65977037424012 1.50912049811266e-07 1.25539961436746e-05 GO:0140030 modification-dependent protein binding 65/3948 173/18639 0.375722543352601 1.77383294973382 5.50819714677773e-07 4.3125943543301e-05 GO:0004842 ubiquitin-protein transferase activity 138/3948 449/18639 0.307349665924276 1.45103607476256 1.01595937978684e-06 7.51245519164605e-05 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 112/3948 349/18639 0.320916905444126 1.51508870328598 1.08002514343874e-06 7.56586034693137e-05 GO:0001221 transcription coregulator binding 47/3948 115/18639 0.408695652173913 1.92950310559006 1.30868919748124e-06 8.70932660923768e-05 GO:0051010 microtubule plus-end binding 14/3948 21/18639 0.666666666666667 3.14741641337386 9.03444226069649e-06 0.000572611554713668 GO:0016504 peptidase activator activity 26/3948 57/18639 0.456140350877193 2.15349544072948 3.1568768602541e-05 0.00190991050045373 GO:0003714 transcription corepressor activity 68/3948 204/18639 0.333333333333333 1.57370820668693 3.50367494336768e-05 0.00202756145635755 GO:0001222 transcription corepressor binding 23/3948 49/18639 0.469387755102041 2.21603808696731 5.1156764697037e-05 0.00283706890882317 GO:0061659 ubiquitin-like protein ligase activity 110/3948 372/18639 0.295698924731183 1.39603147367389 7.46328529492675e-05 0.003973453091019 GO:0035091 phosphatidylinositol binding 87/3948 284/18639 0.306338028169014 1.44626000684961 0.000107649207753791 0.00551081136616523 GO:0099122 RNA polymerase II C-terminal domain binding 8/3948 10/18639 0.8 3.77689969604863 0.000119630166118654 0.00577948826440695 GO:0031491 nucleosome binding 30/3948 74/18639 0.405405405405405 1.91396944056519 0.000122557844404368 0.00577948826440695 GO:0004674 protein serine/threonine kinase activity 124/3948 433/18639 0.286374133949192 1.35200797433612 0.000126651682340567 0.00577948826440695 GO:0032183 SUMO binding 11/3948 17/18639 0.647058823529412 3.05484534239228 0.000130266452240577 0.00577948826440695 GO:0009055 electron transfer activity 42/3948 116/18639 0.362068965517241 1.70937270726339 0.000138750250214361 0.00595730913017145 GO:0019789 SUMO transferase activity 15/3948 28/18639 0.535714285714286 2.52917390360399 0.000164609844272355 0.00684674071020328 GO:0043021 ribonucleoprotein complex binding 58/3948 177/18639 0.327683615819209 1.54703518623461 0.00021249791642264 0.00819949337314538 GO:0106310 protein serine kinase activity 105/3948 361/18639 0.290858725761773 1.37318029115342 0.000214217595700481 0.00819949337314538 GO:0051536 iron-sulfur cluster binding 30/3948 76/18639 0.394736842105263 1.86360182370821 0.000215614025589848 0.00819949337314538 GO:0008135 translation factor activity, RNA binding 32/3948 83/18639 0.385542168674699 1.82019262460175 0.000225610878405896 0.00834133553217356 GO:0035615 clathrin adaptor activity 11/3948 18/18639 0.611111111111111 2.88513171225937 0.000270763011897358 0.00948383075882587 GO:0070628 proteasome binding 11/3948 18/18639 0.611111111111111 2.88513171225937 0.000270763011897358 0.00948383075882587 GO:0051540 metal cluster binding 30/3948 77/18639 0.38961038961039 1.83939920262109 0.000282404572650719 0.00963796118456686 GO:0180051 translation factor activity 32/3948 84/18639 0.380952380952381 1.79852366478506 0.000291235770357649 0.00969087025865076 GO:0005201 extracellular matrix structural constituent 55/3948 168/18639 0.327380952380952 1.54560627442466 0.000313069089003066 0.00994635629220875 GO:0140463 chromatin-protein adaptor activity 23/3948 54/18639 0.425925925925926 2.01084937521108 0.000313859477289833 0.00994635629220875 GO:0016651 oxidoreductase activity, acting on NAD(P)H 33/3948 88/18639 0.375 1.7704217325228 0.000331278043877735 0.0102542110790992 GO:0044389 ubiquitin-like protein ligase binding 94/3948 322/18639 0.291925465838509 1.3782165039929 0.000388655668404631 0.011425404965359 GO:0031625 ubiquitin protein ligase binding 89/3948 302/18639 0.294701986754967 1.3913248052497 0.000389622749268273 0.011425404965359 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 24/3948 58/18639 0.413793103448276 1.95356880830102 0.000394867489411355 0.011425404965359 GO:0060589 nucleoside-triphosphatase regulator activity 135/3948 490/18639 0.275510204081633 1.30071800756777 0.000411650459106509 0.0116575906610801 GO:0030695 GTPase regulator activity 134/3948 489/18639 0.274028629856851 1.2937233110187 0.000548036256919037 0.0151965887074841 GO:0140597 protein carrier chaperone 59/3948 188/18639 0.313829787234043 1.48162953501908 0.000660648821739787 0.017945379219095 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 24/3948 60/18639 0.4 1.88844984802432 0.000712264638373664 0.0189604846735069 GO:0048029 monosaccharide binding 28/3948 74/18639 0.378378378378378 1.78637147786084 0.000769517324317796 0.0200828933071958 GO:1990226 histone methyltransferase binding 10/3948 17/18639 0.588235294117647 2.77713212944752 0.000794646069794809 0.0203225304765287 GO:0061630 ubiquitin protein ligase activity 100/3948 353/18639 0.28328611898017 1.33742907083875 0.000809236750755837 0.0203225304765287 GO:0140104 molecular carrier activity 74/3948 249/18639 0.29718875502008 1.40306514813052 0.000887394055991709 0.0218726201578697 GO:0140098 catalytic activity, acting on RNA 108/3948 387/18639 0.27906976744186 1.31752314978441 0.000915331241665251 0.0221510160482991 GO:0070577 lysine-acetylated histone binding 12/3948 23/18639 0.521739130434783 2.46319545394476 0.00102097155765262 0.0240152205573579 GO:0051219 phosphoprotein binding 33/3948 93/18639 0.354838709677419 1.67523776840867 0.00102845046714455 0.0240152205573579 GO:0003779 actin binding 121/3948 443/18639 0.27313769751693 1.2895171084139 0.00112521110263576 0.0257182172966152 GO:0140097 catalytic activity, acting on DNA 95/3948 336/18639 0.282738095238095 1.33484178245766 0.00115004310067065 0.0257182172966152 GO:0051539 4 iron, 4 sulfur cluster binding 19/3948 45/18639 0.422222222222222 1.99336372847011 0.001159348638465 0.0257182172966152 GO:0043022 ribosome binding 38/3948 112/18639 0.339285714285714 1.6018101389492 0.00118736301892368 0.0259078717735642 GO:0042826 histone deacetylase binding 42/3948 127/18639 0.330708661417323 1.56131680348467 0.00120783248507767 0.0259294360909415 GO:0015279 store-operated calcium channel activity 7/3948 10/18639 0.7 3.30478723404255 0.00124009415308856 0.0261994494882678 GO:0043539 protein serine/threonine kinase activator activity 27/3948 73/18639 0.36986301369863 1.74616938002248 0.00141134555806632 0.0293515771529104 GO:0070064 proline-rich region binding 10/3948 18/18639 0.555555555555556 2.62284701114488 0.00144949989216662 0.0294117050015512 GO:0005484 SNAP receptor activity 16/3948 36/18639 0.444444444444444 2.09827760891591 0.00145843165296948 0.0294117050015512 GO:0140312 cargo adaptor activity 11/3948 21/18639 0.523809523809524 2.47297003907946 0.00158950990141993 0.031576681772984 GO:0140033 acetylation-dependent protein binding 12/3948 24/18639 0.5 2.36056231003039 0.00165079072003354 0.0323118007112446 GO:0016922 nuclear receptor binding 44/3948 137/18639 0.321167883211679 1.51627360060347 0.00181469398968329 0.0350051840618617 GO:0016407 acetyltransferase activity 33/3948 96/18639 0.34375 1.6228865881459 0.00189262254585892 0.0359868658362603 GO:0003727 single-stranded RNA binding 31/3948 89/18639 0.348314606741573 1.64443666541443 0.00201844016516877 0.0378386459132343 GO:0034450 ubiquitin-ubiquitin ligase activity 9/3948 16/18639 0.5625 2.65563259878419 0.00225153275410798 0.0416220846627461 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 25/3948 68/18639 0.367647058823529 1.7357075809047 0.00229322939380174 0.0418121688102756 GO:0046966 nuclear thyroid hormone receptor binding 13/3948 28/18639 0.464285714285714 2.1919507164568 0.00249261456814544 0.0448333782459673 GO:0140035 ubiquitin-like protein reader activity 11/3948 22/18639 0.5 2.36056231003039 0.00257475409260638 0.0453198631380146 GO:0008137 NADH dehydrogenase (ubiquinone) activity 17/3948 41/18639 0.414634146341463 1.95753947661057 0.00262181026418266 0.0453198631380146 GO:0061650 ubiquitin-like protein conjugating enzyme activity 17/3948 41/18639 0.414634146341463 1.95753947661057 0.00262181026418266 0.0453198631380146 GO:0048407 platelet-derived growth factor binding 7/3948 11/18639 0.636363636363636 3.00435203094778 0.00278609266729084 0.0475421710277449 GO:0002039 p53 binding 25/3948 69/18639 0.36231884057971 1.71055239857275 0.00288390371917307 0.0485883019015109 GO:0140566 histone reader activity 15/3948 35/18639 0.428571428571429 2.0233391228832 0.0031451527947727 0.0523274796230307 GO:0031593 polyubiquitin modification-dependent protein binding 22/3948 59/18639 0.372881355932203 1.76041934985318 0.0033462291753045 0.0548106261892274 GO:0030515 snoRNA binding 14/3948 32/18639 0.4375 2.0654920212766 0.00340664919195688 0.0548106261892274 GO:0004197 cysteine-type endopeptidase activity 30/3948 88/18639 0.340909090909091 1.60947430229345 0.00341794288031997 0.0548106261892274 GO:0015631 tubulin binding 104/3948 385/18639 0.27012987012987 1.27531678048395 0.00347799137220076 0.0548818115108114 GO:0061665 SUMO ligase activity 8/3948 14/18639 0.571428571428571 2.69778549717759 0.00350484896951087 0.0548818115108114 GO:0048487 beta-tubulin binding 17/3948 42/18639 0.404761904761905 1.91093139383413 0.00354721366422718 0.0548993184544928 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 13/3948 29/18639 0.448275862068966 2.11636620899277 0.00365133842464472 0.0552264936727514 GO:0097472 cyclin-dependent protein kinase activity 13/3948 29/18639 0.448275862068966 2.11636620899277 0.00365133842464472 0.0552264936727514 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 10/3948 20/18639 0.5 2.36056231003039 0.00402942428709556 0.0602602665856651 GO:0140296 general transcription initiation factor binding 20/3948 53/18639 0.377358490566038 1.7815564604003 0.00429496704880261 0.0635177904661808 GO:0004712 protein serine/threonine/tyrosine kinase activity 17/3948 43/18639 0.395348837209302 1.86649112886124 0.00472611055647247 0.0691258587985149 GO:0004679 AMP-activated protein kinase activity 70/3948 248/18639 0.282258064516129 1.3325754975978 0.00495086601427427 0.0716261159239027 GO:0032451 demethylase activity 16/3948 40/18639 0.4 1.88844984802432 0.00529075743220181 0.0756997889309484 GO:0140713 histone chaperone activity 49/3948 164/18639 0.298780487804878 1.41057991696938 0.00535638946073245 0.0756997889309484 GO:0016853 isomerase activity 53/3948 180/18639 0.294444444444444 1.39010891590679 0.00540306532564996 0.0756997889309484 GO:0140938 histone H3 methyltransferase activity 18/3948 47/18639 0.382978723404255 1.80809028002328 0.0054959343640877 0.0761988399854243 GO:0050431 transforming growth factor beta binding 11/3948 24/18639 0.458333333333333 2.16384878419453 0.00598604739008975 0.0805699128375164 GO:0061775 cohesin loader activity 46/3948 153/18639 0.300653594771242 1.41942308838429 0.00600739898599278 0.0805699128375164 GO:0015929 hexosaminidase activity 8/3948 15/18639 0.533333333333333 2.51793313069909 0.00612501635971836 0.0805699128375164 GO:0001223 transcription coactivator binding 17/3948 44/18639 0.386363636363636 1.82407087593258 0.00620672862201707 0.0805699128375164 GO:0003954 NADH dehydrogenase activity 17/3948 44/18639 0.386363636363636 1.82407087593258 0.00620672862201707 0.0805699128375164 GO:0030020 extracellular matrix structural constituent conferring tensile strength 17/3948 44/18639 0.386363636363636 1.82407087593258 0.00620672862201707 0.0805699128375164 GO:0003743 translation initiation factor activity 19/3948 51/18639 0.372549019607843 1.7588503486501 0.00623493690628414 0.0805699128375164 GO:0005096 GTPase activator activity 75/3948 271/18639 0.276752767527675 1.30658430444487 0.0063245675914572 0.0809423025406686 GO:0030332 cyclin binding 14/3948 34/18639 0.411764705882353 1.94399249061327 0.00656367557661307 0.0830911987493927 GO:0008094 ATP-dependent activity, acting on DNA 60/3948 210/18639 0.285714285714286 1.3488927485888 0.00663860995460827 0.0830911987493927 GO:0035402 histone H3T11 kinase activity 69/3948 247/18639 0.279352226720648 1.31885667523965 0.00679006588450165 0.0830911987493927 GO:0035403 histone H3T6 kinase activity 69/3948 247/18639 0.279352226720648 1.31885667523965 0.00679006588450165 0.0830911987493927 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 68/3948 243/18639 0.279835390946502 1.32113775376187 0.00686453864797838 0.0830911987493927 GO:0140658 ATP-dependent chromatin remodeler activity 47/3948 158/18639 0.29746835443038 1.40438517179024 0.00686704121895807 0.0830911987493927 GO:0140457 protein demethylase activity 13/3948 31/18639 0.419354838709677 1.97982645357388 0.00725852744662971 0.0848873389823397 GO:0042162 telomeric DNA binding 15/3948 38/18639 0.394736842105263 1.86360182370821 0.0078768651257059 0.0848873389823397 GO:0051537 2 iron, 2 sulfur cluster binding 12/3948 28/18639 0.428571428571429 2.0233391228832 0.00797152963250213 0.0848873389823397 GO:0051213 dioxygenase activity 30/3948 93/18639 0.32258064516129 1.52294342582606 0.00834499090466209 0.0848873389823397 GO:0004676 3-phosphoinositide-dependent protein kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0004711 ribosomal protein S6 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0035175 histone H3S10 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0035979 histone H2AXS139 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0044022 histone H3S28 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0044023 histone H4S1 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0044024 histone H2AS1 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0044025 histone H2BS14 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0072354 histone H3T3 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0072371 histone H2AS121 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0072518 Rho-dependent protein serine/threonine kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0140823 histone H2BS36 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0140855 histone H3S57 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0140995 histone H2A kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0140997 histone H4 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0140998 histone H2B kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:1990244 histone H2AT120 kinase activity 68/3948 245/18639 0.277551020408163 1.31035295577197 0.00837231734084524 0.0848873389823397 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 39/3948 128/18639 0.3046875 1.43846765767477 0.0085211377554146 0.0848873389823397 GO:0008239 dipeptidyl-peptidase activity 6/3948 10/18639 0.6 2.83267477203647 0.00854613330100189 0.0848873389823397 GO:1905394 retromer complex binding 6/3948 10/18639 0.6 2.83267477203647 0.00854613330100189 0.0848873389823397 GO:0004677 DNA-dependent protein kinase activity 68/3948 246/18639 0.276422764227642 1.30502631774038 0.00922551072455378 0.089130782942941 GO:0140857 histone H3T45 kinase activity 68/3948 246/18639 0.276422764227642 1.30502631774038 0.00922551072455378 0.089130782942941 GO:0034062 5'-3' RNA polymerase activity 10/3948 22/18639 0.454545454545455 2.14596573639127 0.00930817342529587 0.089130782942941 GO:0061133 endopeptidase activator activity 10/3948 22/18639 0.454545454545455 2.14596573639127 0.00930817342529587 0.089130782942941 GO:0097747 RNA polymerase activity 10/3948 22/18639 0.454545454545455 2.14596573639127 0.00930817342529587 0.089130782942941 GO:0140036 ubiquitin-modified protein reader activity 9/3948 19/18639 0.473684210526316 2.23632218844985 0.00979595969543449 0.091074969092435 GO:0019887 protein kinase regulator activity 70/3948 255/18639 0.274509803921569 1.29599499374218 0.00987585700514363 0.091074969092435 GO:0070717 poly-purine tract binding 13/3948 32/18639 0.40625 1.9179568768997 0.00989402309456371 0.091074969092435 GO:0005521 lamin binding 8/3948 16/18639 0.5 2.36056231003039 0.00999849996532874 0.091074969092435 GO:0015923 mannosidase activity 8/3948 16/18639 0.5 2.36056231003039 0.00999849996532874 0.091074969092435 GO:0030275 LRR domain binding 8/3948 16/18639 0.5 2.36056231003039 0.00999849996532874 0.091074969092435 GO:0097027 ubiquitin-protein transferase activator activity 8/3948 16/18639 0.5 2.36056231003039 0.00999849996532874 0.091074969092435 GO:0008017 microtubule binding 75/3948 276/18639 0.271739130434783 1.28291429892956 0.0100586179238076 0.091074969092435 GO:0046332 SMAD binding 26/3948 79/18639 0.329113924050633 1.55378784964026 0.0101937204147678 0.0916746072436214 GO:0030276 clathrin binding 17/3948 46/18639 0.369565217391304 1.74476344654421 0.0102867685343443 0.0918905296591428 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 12/3948 29/18639 0.413793103448276 1.95356880830102 0.0110210763674603 0.0976294968990151 GO:0005518 collagen binding 24/3948 72/18639 0.333333333333333 1.57370820668693 0.0111959993917041 0.0976294968990151 GO:0051087 protein-folding chaperone binding 40/3948 134/18639 0.298507462686567 1.40929093136143 0.0112177009678759 0.0976294968990151 GO:0016741 transferase activity, transferring one-carbon groups 60/3948 215/18639 0.27906976744186 1.31752314978441 0.0112226243617951 0.0976294968990151 GO:0005516 calmodulin binding 58/3948 207/18639 0.280193236714976 1.32282718822959 0.0114746035500179 0.0988018597475024 GO:0008276 protein methyltransferase activity 30/3948 95/18639 0.315789473684211 1.49088145896657 0.0115150778718201 0.0988018597475024 GO:0140034 methylation-dependent protein binding 25/3948 76/18639 0.328947368421053 1.55300151975684 0.0116862229843902 0.0988018597475024 GO:0055106 ubiquitin-protein transferase regulator activity 14/3948 36/18639 0.388888888888889 1.83599290780142 0.0117017053171541 0.0988018597475024 GO:0048156 tau protein binding 16/3948 43/18639 0.372093023255814 1.75669753304588 0.0117285453344143 0.0988018597475024 GO:1902936 phosphatidylinositol bisphosphate binding 34/3948 111/18639 0.306306306306306 1.44611024398258 0.0123015174838409 0.102594457402651 GO:0051287 NAD binding 19/3948 54/18639 0.351851851851852 1.66113644039176 0.0123420459757539 0.102594457402651 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 48/3948 167/18639 0.287425149700599 1.35696995067616 0.0124990201646372 0.102594457402651 GO:0000510 H3-H4 histone complex chaperone activity 44/3948 151/18639 0.291390728476821 1.37569194226937 0.0127183211656179 0.102594457402651 GO:0140584 chromatin extrusion motor activity 44/3948 151/18639 0.291390728476821 1.37569194226937 0.0127183211656179 0.102594457402651 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 44/3948 151/18639 0.291390728476821 1.37569194226937 0.0127183211656179 0.102594457402651 GO:0140849 ATP-dependent H2AZ histone chaperone activity 44/3948 151/18639 0.291390728476821 1.37569194226937 0.0127183211656179 0.102594457402651 GO:0061733 protein-lysine-acetyltransferase activity 17/3948 47/18639 0.361702127659574 1.70764082002199 0.0130015745641564 0.104247564728266 GO:0140416 transcription regulator inhibitor activity 13/3948 33/18639 0.393939393939394 1.8598369715391 0.0132190506344348 0.105356625116364 GO:0030544 Hsp70 protein binding 18/3948 51/18639 0.352941176470588 1.66627927766851 0.0141564436511633 0.111024019622439 GO:0003689 DNA clamp loader activity 46/3948 160/18639 0.2875 1.35732332826748 0.014168438390913 0.111024019622439 GO:0015616 DNA translocase activity 44/3948 152/18639 0.289473684210526 1.36664133738602 0.0143141150098692 0.111024019622439 GO:0140674 ATP-dependent histone chaperone activity 44/3948 152/18639 0.289473684210526 1.36664133738602 0.0143141150098692 0.111024019622439 GO:0000287 magnesium ion binding 63/3948 230/18639 0.273913043478261 1.293177613321 0.0144404272112432 0.111024019622439 GO:0000339 RNA cap binding 9/3948 20/18639 0.45 2.12450607902736 0.0145140341204391 0.111024019622439 GO:0061608 nuclear import signal receptor activity 9/3948 20/18639 0.45 2.12450607902736 0.0145140341204391 0.111024019622439 GO:0032452 histone demethylase activity 12/3948 30/18639 0.4 1.88844984802432 0.0148951059061627 0.113287919777729 GO:1901981 phosphatidylinositol phosphate binding 52/3948 185/18639 0.281081081081081 1.3270188121252 0.0150336249907566 0.113673150960203 GO:0004659 prenyltransferase activity 8/3948 17/18639 0.470588235294118 2.22170570355802 0.0154278063576562 0.113673150960203 GO:0005092 GDP-dissociation inhibitor activity 8/3948 17/18639 0.470588235294118 2.22170570355802 0.0154278063576562 0.113673150960203 GO:0032977 membrane insertase activity 8/3948 17/18639 0.470588235294118 2.22170570355802 0.0154278063576562 0.113673150960203 GO:0032050 clathrin heavy chain binding 6/3948 11/18639 0.545454545454545 2.57515888366952 0.0154581820614551 0.113673150960203 GO:0140031 phosphorylation-dependent protein binding 6/3948 11/18639 0.545454545454545 2.57515888366952 0.0154581820614551 0.113673150960203 GO:0004065 arylsulfatase activity 7/3948 14/18639 0.5 2.36056231003039 0.0158876496908036 0.114743465033653 GO:0008174 mRNA methyltransferase activity 7/3948 14/18639 0.5 2.36056231003039 0.0158876496908036 0.114743465033653 GO:0070742 C2H2 zinc finger domain binding 7/3948 14/18639 0.5 2.36056231003039 0.0158876496908036 0.114743465033653 GO:0035064 methylated histone binding 24/3948 74/18639 0.324324324324324 1.53117555245215 0.0159485657635056 0.114743465033653 GO:0016791 phosphatase activity 73/3948 273/18639 0.267399267399267 1.2624252647049 0.0160436867823798 0.114807242512621 GO:0042054 histone methyltransferase activity 22/3948 67/18639 0.328358208955224 1.55022002449757 0.0176725813245293 0.125787196486356 GO:0019207 kinase regulator activity 76/3948 287/18639 0.264808362369338 1.25019327917986 0.0179271238403625 0.126920222508098 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 62/3948 229/18639 0.270742358078603 1.27820841241821 0.0192999632224379 0.135916672217274 GO:0140101 catalytic activity, acting on a tRNA 40/3948 139/18639 0.287769784172662 1.35859701296713 0.0207090067771137 0.145072042212307 GO:0031072 heat shock protein binding 38/3948 131/18639 0.290076335877863 1.36948653101 0.0209209515565265 0.145789458228988 GO:0016859 cis-trans isomerase activity 15/3948 42/18639 0.357142857142857 1.686115935736 0.021443238877658 0.147880574850584 GO:0051879 Hsp90 protein binding 15/3948 42/18639 0.357142857142857 1.686115935736 0.021443238877658 0.147880574850584 GO:0061631 ubiquitin conjugating enzyme activity 13/3948 35/18639 0.371428571428571 1.75356057316544 0.0223596175084592 0.151256714834247 GO:0036408 histone H3K14 acetyltransferase activity 11/3948 28/18639 0.392857142857143 1.8547275293096 0.0223873574923717 0.151256714834247 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 11/3948 28/18639 0.392857142857143 1.8547275293096 0.0223873574923717 0.151256714834247 GO:0141052 histone H3 demethylase activity 11/3948 28/18639 0.392857142857143 1.8547275293096 0.0223873574923717 0.151256714834247 GO:1990381 ubiquitin-specific protease binding 8/3948 18/18639 0.444444444444444 2.09827760891591 0.022704802919178 0.152626730734475 GO:0051117 ATPase binding 26/3948 84/18639 0.30952380952381 1.46130047763786 0.0229755965362985 0.153670949697554 GO:0044325 transmembrane transporter binding 39/3948 136/18639 0.286764705882353 1.35385191310567 0.0233830063113279 0.155613907001887 GO:0004559 alpha-mannosidase activity 7/3948 15/18639 0.466666666666667 2.2031914893617 0.0244299538555031 0.160971626641954 GO:0120283 protein serine/threonine kinase binding 7/3948 15/18639 0.466666666666667 2.2031914893617 0.0244299538555031 0.160971626641954 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 14/3948 39/18639 0.358974358974359 1.69476268412439 0.0246610244018423 0.161693711718484 GO:0016279 protein-lysine N-methyltransferase activity 22/3948 69/18639 0.318840579710145 1.50528611074402 0.0248607851138282 0.162204436208359 GO:0035173 histone kinase activity 92/3948 360/18639 0.255555555555556 1.20650962512665 0.0253450743108807 0.162846844828638 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 10/3948 25/18639 0.4 1.88844984802432 0.0253556556864162 0.162846844828638 GO:0017166 vinculin binding 6/3948 12/18639 0.5 2.36056231003039 0.0254486429183747 0.162846844828638 GO:0035497 cAMP response element binding 6/3948 12/18639 0.5 2.36056231003039 0.0254486429183747 0.162846844828638 GO:0019208 phosphatase regulator activity 34/3948 117/18639 0.290598290598291 1.37195074429117 0.0270381709649997 0.172190457198156 GO:0140996 histone H3 kinase activity 91/3948 357/18639 0.254901960784314 1.20342392276059 0.0276762715946121 0.175414845202042 GO:0008168 methyltransferase activity 55/3948 204/18639 0.269607843137255 1.27285222599678 0.0283310734101817 0.176535722355265 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 13/3948 36/18639 0.361111111111111 1.70485055724417 0.0283836548339794 0.176535722355265 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 13/3948 36/18639 0.361111111111111 1.70485055724417 0.0283836548339794 0.176535722355265 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 13/3948 36/18639 0.361111111111111 1.70485055724417 0.0283836548339794 0.176535722355265 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 9/3948 22/18639 0.409090909090909 1.93136916275214 0.0286101950990024 0.177117068264057 GO:0004721 phosphoprotein phosphatase activity 48/3948 175/18639 0.274285714285714 1.29493703864525 0.028885798440126 0.177995359832443 GO:0016278 lysine N-methyltransferase activity 22/3948 70/18639 0.314285714285714 1.48378202344768 0.0292032413599459 0.178277532407933 GO:0010484 histone H3 acetyltransferase activity 11/3948 29/18639 0.379310344827586 1.79077140760927 0.0293334181798177 0.178277532407933 GO:0106222 lncRNA binding 11/3948 29/18639 0.379310344827586 1.79077140760927 0.0293334181798177 0.178277532407933 GO:0051015 actin filament binding 56/3948 209/18639 0.267942583732057 1.26499032882012 0.0304051732803454 0.183485707734649 GO:0022853 active monoatomic ion transmembrane transporter activity 34/3948 118/18639 0.288135593220339 1.36032404306836 0.0304660716824624 0.183485707734649 GO:0004177 aminopeptidase activity 14/3948 40/18639 0.35 1.65239361702128 0.030741658625234 0.184311475811651 GO:0004386 helicase activity 43/3948 155/18639 0.27741935483871 1.30973134621041 0.0309940666074943 0.184991491724551 GO:0004879 nuclear receptor activity 19/3948 59/18639 0.322033898305085 1.52036216578229 0.0320295154199447 0.18984823522671 GO:0042800 histone H3K4 methyltransferase activity 8/3948 19/18639 0.421052631578947 1.98784194528875 0.0320930525364461 0.18984823522671 GO:0071889 14-3-3 protein binding 12/3948 33/18639 0.363636363636364 1.71677258911301 0.0326948153488634 0.192552208979368 GO:0034237 protein kinase A regulatory subunit binding 10/3948 26/18639 0.384615384615385 1.81581716156184 0.03357697753444 0.19687646298828 GO:0032266 phosphatidylinositol-3-phosphate binding 16/3948 48/18639 0.333333333333333 1.57370820668693 0.0343992920577551 0.200414120666415 GO:0017124 SH3 domain binding 33/3948 115/18639 0.28695652173913 1.35475749966962 0.0344814677930947 0.200414120666415 GO:0004708 MAP kinase kinase activity 7/3948 16/18639 0.4375 2.0654920212766 0.0356544179923054 0.205437360812808 GO:0017070 U6 snRNA binding 7/3948 16/18639 0.4375 2.0654920212766 0.0356544179923054 0.205437360812808 GO:0002020 protease binding 38/3948 136/18639 0.279411764705882 1.31913776148757 0.0366382327358649 0.209293938933203 GO:0019838 growth factor binding 38/3948 136/18639 0.279411764705882 1.31913776148757 0.0366382327358649 0.209293938933203 GO:0043995 histone H4K5 acetyltransferase activity 11/3948 30/18639 0.366666666666667 1.73107902735562 0.0376924410750915 0.212521130961018 GO:0043996 histone H4K8 acetyltransferase activity 11/3948 30/18639 0.366666666666667 1.73107902735562 0.0376924410750915 0.212521130961018 GO:0043997 histone H4K12 acetyltransferase activity 11/3948 30/18639 0.366666666666667 1.73107902735562 0.0376924410750915 0.212521130961018 GO:0098531 ligand-modulated transcription factor activity 19/3948 60/18639 0.316666666666667 1.49502279635258 0.0378418542732993 0.212521130961018 GO:0017154 semaphorin receptor activity 6/3948 13/18639 0.461538461538462 2.17898059387421 0.0389506945654182 0.216014060277382 GO:0019104 DNA N-glycosylase activity 6/3948 13/18639 0.461538461538462 2.17898059387421 0.0389506945654182 0.216014060277382 GO:0140852 histone ubiquitin ligase activity 6/3948 13/18639 0.461538461538462 2.17898059387421 0.0389506945654182 0.216014060277382 GO:0141003 histone H2AX kinase activity 89/3948 354/18639 0.251412429378531 1.18694941012828 0.0399147368181192 0.21848883311545 GO:0005528 FK506 binding 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0008140 cAMP response element binding protein binding 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0008641 ubiquitin-like modifier activating enzyme activity 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0042975 peroxisome proliferator activated receptor binding 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0043121 neurotrophin binding 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0050815 phosphoserine residue binding 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0097177 mitochondrial ribosome binding 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:1990757 ubiquitin ligase activator activity 5/3948 10/18639 0.5 2.36056231003039 0.0412026274319895 0.21848883311545 GO:0034212 protein N-acetyltransferase activity 17/3948 53/18639 0.320754716981132 1.51432299134025 0.0426047138010529 0.225027278052386 GO:0016505 peptidase activator activity involved in apoptotic process 8/3948 20/18639 0.4 1.88844984802432 0.0438123981471175 0.229583865881155 GO:0031418 L-ascorbic acid binding 8/3948 20/18639 0.4 1.88844984802432 0.0438123981471175 0.229583865881155 GO:0016874 ligase activity 45/3948 167/18639 0.269461077844311 1.2721593287589 0.0441028512075151 0.230199588067461 GO:0004402 histone acetyltransferase activity 14/3948 42/18639 0.333333333333333 1.57370820668693 0.0460452645998921 0.23939940305647 GO:0004550 nucleoside diphosphate kinase activity 7/3948 17/18639 0.411764705882353 1.94399249061327 0.0498130461365598 0.254027449838165 GO:0008484 sulfuric ester hydrolase activity 7/3948 17/18639 0.411764705882353 1.94399249061327 0.0498130461365598 0.254027449838165 GO:0015278 intracellularly gated calcium channel activity 7/3948 17/18639 0.411764705882353 1.94399249061327 0.0498130461365598 0.254027449838165 GO:0048038 quinone binding 7/3948 17/18639 0.411764705882353 1.94399249061327 0.0498130461365598 0.254027449838165 GO:0070402 NADPH binding 7/3948 17/18639 0.411764705882353 1.94399249061327 0.0498130461365598 0.254027449838165 GO:0070840 dynein complex binding 9/3948 24/18639 0.375 1.7704217325228 0.0502199050701769 0.255124784917578 GO:0010485 histone H4 acetyltransferase activity 12/3948 35/18639 0.342857142857143 1.61867129830656 0.0508329890541855 0.257257446506163 GO:0019902 phosphatase binding 50/3948 190/18639 0.263157894736842 1.24240121580547 0.0519447054751411 0.261887890103837 GO:0097110 scaffold protein binding 21/3948 70/18639 0.3 1.41633738601824 0.0523348892234189 0.262859387005172 GO:0097718 disordered domain specific binding 10/3948 28/18639 0.357142857142857 1.686115935736 0.0552144614675 0.275359153552326 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 68/3948 268/18639 0.253731343283582 1.19789729165722 0.0552373358365673 0.275359153552326 GO:0140789 histone phosphatase activity 37/3948 136/18639 0.272058823529412 1.28442360986948 0.0556224335527895 0.276244250219264 GO:0005347 ATP transmembrane transporter activity 6/3948 14/18639 0.428571428571429 2.0233391228832 0.0562479782213792 0.278312487035895 GO:0010314 phosphatidylinositol-5-phosphate binding 8/3948 21/18639 0.380952380952381 1.79852366478506 0.0580268502344429 0.284340383441101 GO:0019200 carbohydrate kinase activity 8/3948 21/18639 0.380952380952381 1.79852366478506 0.0580268502344429 0.284340383441101 GO:0005048 signal sequence binding 16/3948 51/18639 0.313725490196078 1.48113713570535 0.0581071256919455 0.284340383441101 GO:0140142 nucleocytoplasmic carrier activity 11/3948 32/18639 0.34375 1.6228865881459 0.0590840335686122 0.288061716775908 GO:0045309 protein phosphorylated amino acid binding 18/3948 59/18639 0.305084745762712 1.44034310442533 0.0595087153933107 0.289073358352177 GO:0001217 DNA-binding transcription repressor activity 70/3948 278/18639 0.251798561151079 1.18877238634624 0.0603494313327339 0.292091247650432 GO:0044390 ubiquitin-like protein conjugating enzyme binding 12/3948 36/18639 0.333333333333333 1.57370820668693 0.0620576561642885 0.297841349174269 GO:0005536 D-glucose binding 5/3948 11/18639 0.454545454545455 2.14596573639127 0.0626563319074345 0.297841349174269 GO:0015217 ADP transmembrane transporter activity 5/3948 11/18639 0.454545454545455 2.14596573639127 0.0626563319074345 0.297841349174269 GO:0043522 leucine zipper domain binding 5/3948 11/18639 0.454545454545455 2.14596573639127 0.0626563319074345 0.297841349174269 GO:0140537 transcription regulator activator activity 5/3948 11/18639 0.454545454545455 2.14596573639127 0.0626563319074345 0.297841349174269 GO:0003707 nuclear steroid receptor activity 9/3948 25/18639 0.36 1.69960486322188 0.0642060453485423 0.300357954418224 GO:0042974 nuclear retinoic acid receptor binding 9/3948 25/18639 0.36 1.69960486322188 0.0642060453485423 0.300357954418224 GO:0030331 nuclear estrogen receptor binding 13/3948 40/18639 0.325 1.53436550151976 0.064314062366036 0.300357954418224 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 13/3948 40/18639 0.325 1.53436550151976 0.064314062366036 0.300357954418224 GO:0050997 quaternary ammonium group binding 13/3948 40/18639 0.325 1.53436550151976 0.064314062366036 0.300357954418224 GO:0003697 single-stranded DNA binding 33/3948 121/18639 0.272727272727273 1.28757944183476 0.0656216385969105 0.305393010393314 GO:0001046 core promoter sequence-specific DNA binding 14/3948 44/18639 0.318181818181818 1.50217601547389 0.0659925116240174 0.306048895371314 GO:0004860 protein kinase inhibitor activity 24/3948 84/18639 0.285714285714286 1.3488927485888 0.0668762607812621 0.3084343245883 GO:0003746 translation elongation factor activity 7/3948 18/18639 0.388888888888889 1.83599290780142 0.0670637463658028 0.3084343245883 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 15/3948 48/18639 0.3125 1.475351443769 0.0672020692190887 0.3084343245883 GO:0000049 tRNA binding 23/3948 80/18639 0.2875 1.35732332826748 0.067477551950575 0.308634438646788 GO:0019212 phosphatase inhibitor activity 17/3948 56/18639 0.303571428571429 1.4331985453756 0.0685412907435916 0.31163537454541 GO:0015078 proton transmembrane transporter activity 48/3948 185/18639 0.259459459459459 1.22494044196172 0.0688119848090751 0.31163537454541 GO:0016417 S-acyltransferase activity 10/3948 29/18639 0.344827586206897 1.62797400691751 0.0688360631978592 0.31163537454541 GO:0030295 protein kinase activator activity 37/3948 139/18639 0.266187050359712 1.2567022369946 0.0734097284416004 0.320280402193564 GO:0140767 enzyme-substrate adaptor activity 37/3948 139/18639 0.266187050359712 1.2567022369946 0.0734097284416004 0.320280402193564 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 25/3948 89/18639 0.280898876404494 1.32615860114067 0.0742187387050814 0.320280402193564 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 25/3948 89/18639 0.280898876404494 1.32615860114067 0.0742187387050814 0.320280402193564 GO:0032931 histone H3K56 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0043992 histone H3K9 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0043993 histone H3K18 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0043994 histone H3K23 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0043999 histone H2AK5 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0044012 histone H2AK9 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0044014 histone H2BK5 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0044015 histone H2BK12 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0044016 histone H3K4 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0044017 histone H3K27 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0044018 histone H3K36 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0050321 tau-protein kinase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0140908 histone H3K122 acetyltransferase activity 8/3948 22/18639 0.363636363636364 1.71677258911301 0.0748363674546946 0.320280402193564 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 13/3948 41/18639 0.317073170731707 1.4969419527022 0.0766034605478056 0.325234235436308 GO:0019209 kinase activator activity 39/3948 148/18639 0.263513513513513 1.24408013636737 0.0768601638709509 0.325234235436308 GO:0000774 adenyl-nucleotide exchange factor activity 6/3948 15/18639 0.4 1.88844984802432 0.0774599944652966 0.325234235436308 GO:0031005 filamin binding 6/3948 15/18639 0.4 1.88844984802432 0.0774599944652966 0.325234235436308 GO:0042809 nuclear vitamin D receptor binding 6/3948 15/18639 0.4 1.88844984802432 0.0774599944652966 0.325234235436308 GO:0061578 K63-linked deubiquitinase activity 6/3948 15/18639 0.4 1.88844984802432 0.0774599944652966 0.325234235436308 GO:0019783 ubiquitin-like protein peptidase activity 34/3948 127/18639 0.267716535433071 1.26392312663045 0.0779066657449607 0.326081044360197 GO:0008080 N-acetyltransferase activity 20/3948 69/18639 0.289855072463768 1.3684419188582 0.0782025257827604 0.326293297231517 GO:0060590 ATPase regulator activity 15/3948 49/18639 0.306122448979592 1.44524223063085 0.0786123129715407 0.326978089266002 GO:0016860 intramolecular oxidoreductase activity 16/3948 53/18639 0.30188679245283 1.42524516832024 0.0790230263175513 0.327662454917946 GO:0008143 poly(A) binding 9/3948 26/18639 0.346153846153846 1.63423544540566 0.0804214341913024 0.330373237372295 GO:0050681 nuclear androgen receptor binding 9/3948 26/18639 0.346153846153846 1.63423544540566 0.0804214341913024 0.330373237372295 GO:0120014 phospholipid transfer activity 9/3948 26/18639 0.346153846153846 1.63423544540566 0.0804214341913024 0.330373237372295 GO:0140793 histone H2AXY142 phosphatase activity 25/3948 90/18639 0.277777777777778 1.31142350557244 0.08287256927035 0.339395045227187 GO:0015215 nucleotide transmembrane transporter activity 10/3948 30/18639 0.333333333333333 1.57370820668693 0.084407874259243 0.343568442321261 GO:0031210 phosphatidylcholine binding 10/3948 30/18639 0.333333333333333 1.57370820668693 0.084407874259243 0.343568442321261 GO:0019888 protein phosphatase regulator activity 29/3948 107/18639 0.271028037383178 1.27955714001648 0.0857590101626931 0.348003788190684 GO:0005346 purine ribonucleotide transmembrane transporter activity 7/3948 19/18639 0.368421052631579 1.73936170212766 0.0874633177662608 0.350352387106516 GO:0003684 damaged DNA binding 21/3948 74/18639 0.283783783783784 1.33977860839563 0.0875567120717115 0.350352387106516 GO:0000340 RNA 7-methylguanosine cap binding 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0004300 enoyl-CoA hydratase activity 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0005095 GTPase inhibitor activity 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0005527 macrolide binding 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0016840 carbon-nitrogen lyase activity 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0034452 dynactin binding 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0035197 siRNA binding 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0035259 nuclear glucocorticoid receptor binding 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0070679 inositol 1,4,5 trisphosphate binding 5/3948 12/18639 0.416666666666667 1.96713525835866 0.0892332526139059 0.350352387106516 GO:0003925 G protein activity 16/3948 54/18639 0.296296296296296 1.39885173927727 0.0911130307151287 0.354594865151568 GO:0017069 snRNA binding 16/3948 54/18639 0.296296296296296 1.39885173927727 0.0911130307151287 0.354594865151568 GO:0050661 NADP binding 16/3948 54/18639 0.296296296296296 1.39885173927727 0.0911130307151287 0.354594865151568 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 25/3948 91/18639 0.274725274725275 1.29701225825846 0.0921774761151898 0.357691605566524 GO:0044013 histone H2B acetyltransferase activity 8/3948 23/18639 0.347826086956522 1.64213030262984 0.0942726971652314 0.364758604438729 GO:0019003 GDP binding 21/3948 75/18639 0.28 1.32191489361702 0.098330162837986 0.379354918079302 GO:0016798 hydrolase activity, acting on glycosyl bonds 34/3948 130/18639 0.261538461538462 1.23475566986205 0.101427023372441 0.388846683773905 GO:0008327 methyl-CpG binding 10/3948 31/18639 0.32258064516129 1.52294342582606 0.101945781422564 0.388846683773905 GO:0016411 acylglycerol O-acyltransferase activity 10/3948 31/18639 0.32258064516129 1.52294342582606 0.101945781422564 0.388846683773905 GO:0005024 transforming growth factor beta receptor activity 6/3948 16/18639 0.375 1.7704217325228 0.102543340349091 0.388846683773905 GO:0043023 ribosomal large subunit binding 6/3948 16/18639 0.375 1.7704217325228 0.102543340349091 0.388846683773905 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 6/3948 16/18639 0.375 1.7704217325228 0.102543340349091 0.388846683773905 GO:0140313 molecular sequestering activity 16/3948 55/18639 0.290909090909091 1.37341807129041 0.104311379341518 0.394427403135113 GO:0043495 protein-membrane adaptor activity 14/3948 47/18639 0.297872340425532 1.40629244001811 0.105396583996576 0.397401850706635 GO:0005543 phospholipid binding 117/3948 497/18639 0.235412474849095 1.1114116308795 0.106705081012632 0.401199047536197 GO:0043024 ribosomal small subunit binding 7/3948 20/18639 0.35 1.65239361702128 0.110967659099646 0.414881893993338 GO:0140939 histone H4 methyltransferase activity 7/3948 20/18639 0.35 1.65239361702128 0.110967659099646 0.414881893993338 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/3948 24/18639 0.333333333333333 1.57370820668693 0.116299093212759 0.432385734821738 GO:0043998 histone H2A acetyltransferase activity 8/3948 24/18639 0.333333333333333 1.57370820668693 0.116299093212759 0.432385734821738 GO:0016779 nucleotidyltransferase activity 35/3948 136/18639 0.257352941176471 1.21499530663329 0.116645973811903 0.432467384801232 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 17/3948 60/18639 0.283333333333333 1.33765197568389 0.117078924714708 0.432866802209099 GO:0016866 intramolecular transferase activity 9/3948 28/18639 0.321428571428571 1.5175043421624 0.119573849587255 0.437997811721064 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/3948 13/18639 0.384615384615385 1.81581716156184 0.120659851394211 0.437997811721064 GO:0030955 potassium ion binding 5/3948 13/18639 0.384615384615385 1.81581716156184 0.120659851394211 0.437997811721064 GO:0046975 histone H3K36 methyltransferase activity 5/3948 13/18639 0.384615384615385 1.81581716156184 0.120659851394211 0.437997811721064 GO:0097157 pre-mRNA intronic binding 5/3948 13/18639 0.384615384615385 1.81581716156184 0.120659851394211 0.437997811721064 GO:0004725 protein tyrosine phosphatase activity 26/3948 98/18639 0.26530612244898 1.25254326654674 0.121335188731398 0.437997811721064 GO:0008170 N-methyltransferase activity 26/3948 98/18639 0.26530612244898 1.25254326654674 0.121335188731398 0.437997811721064 GO:0031369 translation initiation factor binding 10/3948 32/18639 0.3125 1.475351443769 0.121428394083451 0.437997811721064 GO:0051059 NF-kappaB binding 10/3948 32/18639 0.3125 1.475351443769 0.121428394083451 0.437997811721064 GO:0019205 nucleobase-containing compound kinase activity 13/3948 44/18639 0.295454545454545 1.39487772865432 0.121956874992143 0.438715136796061 GO:0003724 RNA helicase activity 21/3948 77/18639 0.272727272727273 1.28757944183476 0.122308140243477 0.438792815806113 GO:0019210 kinase inhibitor activity 24/3948 90/18639 0.266666666666667 1.25896656534954 0.126857461488734 0.453890540971786 GO:0008429 phosphatidylethanolamine binding 6/3948 17/18639 0.352941176470588 1.66627927766851 0.131305319010472 0.466046345607836 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/3948 17/18639 0.352941176470588 1.66627927766851 0.131305319010472 0.466046345607836 GO:0030169 low-density lipoprotein particle binding 6/3948 17/18639 0.352941176470588 1.66627927766851 0.131305319010472 0.466046345607836 GO:0004864 protein phosphatase inhibitor activity 15/3948 53/18639 0.283018867924528 1.33616734530022 0.136156212621486 0.477547587860689 GO:0016251 RNA polymerase II general transcription initiation factor activity 15/3948 53/18639 0.283018867924528 1.33616734530022 0.136156212621486 0.477547587860689 GO:0035613 RNA stem-loop binding 7/3948 21/18639 0.333333333333333 1.57370820668693 0.137438063532247 0.477547587860689 GO:0051082 unfolded protein binding 31/3948 121/18639 0.256198347107438 1.20954432414781 0.139097977225939 0.477547587860689 GO:0000030 mannosyltransferase activity 8/3948 25/18639 0.32 1.51075987841945 0.140813468678272 0.477547587860689 GO:0004709 MAP kinase kinase kinase activity 8/3948 25/18639 0.32 1.51075987841945 0.140813468678272 0.477547587860689 GO:0008483 transaminase activity 8/3948 25/18639 0.32 1.51075987841945 0.140813468678272 0.477547587860689 GO:0001727 lipid kinase activity 12/3948 41/18639 0.292682926829268 1.38179257172511 0.141330272882321 0.477547587860689 GO:0042169 SH2 domain binding 12/3948 41/18639 0.292682926829268 1.38179257172511 0.141330272882321 0.477547587860689 GO:0140318 protein transporter activity 12/3948 41/18639 0.292682926829268 1.38179257172511 0.141330272882321 0.477547587860689 GO:0042805 actinin binding 11/3948 37/18639 0.297297297297297 1.4035775897478 0.142358093983633 0.477547587860689 GO:0043394 proteoglycan binding 11/3948 37/18639 0.297297297297297 1.4035775897478 0.142358093983633 0.477547587860689 GO:0099604 ligand-gated calcium channel activity 9/3948 29/18639 0.310344827586207 1.46517660622576 0.142405853462483 0.477547587860689 GO:0005522 profilin binding 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0016868 intramolecular phosphotransferase activity 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0043422 protein kinase B binding 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0045322 unmethylated CpG binding 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0047429 nucleoside triphosphate diphosphatase activity 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0140940 histone H2A methyltransferase activity 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0140999 histone H3K4 trimethyltransferase activity 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:1990259 histone H2AQ104 methyltransferase activity 4/3948 10/18639 0.4 1.88844984802432 0.142536567764918 0.477547587860689 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 10/3948 33/18639 0.303030303030303 1.43064382426085 0.142797851216044 0.477547587860689 GO:0016829 lyase activity 49/3948 200/18639 0.245 1.15667553191489 0.143183394398726 0.477636836954147 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 22/3948 83/18639 0.265060240963855 1.2513824294137 0.146018068719594 0.485875123664449 GO:0008186 ATP-dependent activity, acting on RNA 21/3948 79/18639 0.265822784810127 1.25498249394021 0.149506816463289 0.49624332347291 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 31/3948 122/18639 0.254098360655738 1.19963002640889 0.150346977224537 0.496555401205604 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 31/3948 122/18639 0.254098360655738 1.19963002640889 0.150346977224537 0.496555401205604 GO:0019903 protein phosphatase binding 36/3948 144/18639 0.25 1.1802811550152 0.153106964868313 0.504419233266644 GO:0015605 organophosphate ester transmembrane transporter activity 14/3948 50/18639 0.28 1.32191489361702 0.156375467287205 0.510360941126483 GO:0005545 1-phosphatidylinositol binding 5/3948 14/18639 0.357142857142857 1.686115935736 0.156444225379117 0.510360941126483 GO:0016530 metallochaperone activity 5/3948 14/18639 0.357142857142857 1.686115935736 0.156444225379117 0.510360941126483 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 5/3948 14/18639 0.357142857142857 1.686115935736 0.156444225379117 0.510360941126483 GO:0030291 protein serine/threonine kinase inhibitor activity 13/3948 46/18639 0.282608695652174 1.33423087088674 0.159150802074396 0.517921069831348 GO:0050840 extracellular matrix binding 18/3948 67/18639 0.26865671641791 1.26836183822529 0.160430595332663 0.520812493628718 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 6/3948 18/18639 0.333333333333333 1.57370820668693 0.163426105332807 0.522594778273654 GO:0008409 5'-3' exonuclease activity 6/3948 18/18639 0.333333333333333 1.57370820668693 0.163426105332807 0.522594778273654 GO:0016854 racemase and epimerase activity 6/3948 18/18639 0.333333333333333 1.57370820668693 0.163426105332807 0.522594778273654 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 6/3948 18/18639 0.333333333333333 1.57370820668693 0.163426105332807 0.522594778273654 GO:1901611 phosphatidylglycerol binding 6/3948 18/18639 0.333333333333333 1.57370820668693 0.163426105332807 0.522594778273654 GO:0043531 ADP binding 11/3948 38/18639 0.289473684210526 1.36664133738602 0.164056121631792 0.522594778273654 GO:0046972 histone H4K16 acetyltransferase activity 7/3948 22/18639 0.318181818181818 1.50217601547389 0.166652188368438 0.522594778273654 GO:0008013 beta-catenin binding 27/3948 106/18639 0.254716981132075 1.2025506107702 0.166737451645004 0.522594778273654 GO:0001968 fibronectin binding 9/3948 30/18639 0.3 1.41633738601824 0.167262130263872 0.522594778273654 GO:0016769 transferase activity, transferring nitrogenous groups 9/3948 30/18639 0.3 1.41633738601824 0.167262130263872 0.522594778273654 GO:0031624 ubiquitin conjugating enzyme binding 9/3948 30/18639 0.3 1.41633738601824 0.167262130263872 0.522594778273654 GO:0035925 mRNA 3'-UTR AU-rich region binding 9/3948 30/18639 0.3 1.41633738601824 0.167262130263872 0.522594778273654 GO:0005112 Notch binding 8/3948 26/18639 0.307692307692308 1.45265372924947 0.167654372894703 0.522594778273654 GO:0008198 ferrous iron binding 8/3948 26/18639 0.307692307692308 1.45265372924947 0.167654372894703 0.522594778273654 GO:0015216 purine nucleotide transmembrane transporter activity 8/3948 26/18639 0.307692307692308 1.45265372924947 0.167654372894703 0.522594778273654 GO:0052742 phosphatidylinositol kinase activity 8/3948 26/18639 0.307692307692308 1.45265372924947 0.167654372894703 0.522594778273654 GO:0070006 metalloaminopeptidase activity 8/3948 26/18639 0.307692307692308 1.45265372924947 0.167654372894703 0.522594778273654 GO:0031490 chromatin DNA binding 32/3948 128/18639 0.25 1.1802811550152 0.169826662912798 0.528129178357323 GO:0005085 guanyl-nucleotide exchange factor activity 55/3948 230/18639 0.239130434782609 1.12896458305802 0.173336417438627 0.53778734641215 GO:1990841 promoter-specific chromatin binding 18/3948 68/18639 0.264705882352941 1.24970945825139 0.177275069529981 0.546429571413772 GO:0033192 calmodulin-dependent protein phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0140791 histone H2AXS140 phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:1990439 MAP kinase serine/threonine phosphatase activity 21/3948 81/18639 0.259259259259259 1.22399527186761 0.179816793598221 0.546429571413772 GO:0016410 N-acyltransferase activity 24/3948 94/18639 0.25531914893617 1.20539352001552 0.18059968690627 0.547558504037006 GO:0008200 ion channel inhibitor activity 12/3948 43/18639 0.27906976744186 1.31752314978441 0.183542751116366 0.551697790299237 GO:0004722 protein serine/threonine phosphatase activity 26/3948 103/18639 0.252427184466019 1.19174019535515 0.185182784054439 0.551697790299237 GO:0016776 phosphotransferase activity, phosphate group as acceptor 11/3948 39/18639 0.282051282051282 1.33159925181202 0.187270763207206 0.551697790299237 GO:0002162 dystroglycan binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0005114 type II transforming growth factor beta receptor binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0008526 phosphatidylinositol transfer activity 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0016176 superoxide-generating NADPH oxidase activator activity 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0019107 myristoyltransferase activity 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0019203 carbohydrate phosphatase activity 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0032794 GTPase activating protein binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0034056 estrogen response element binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0034511 U3 snoRNA binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0045294 alpha-catenin binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0048185 activin binding 4/3948 11/18639 0.363636363636364 1.71677258911301 0.188182416826336 0.551697790299237 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 22/3948 86/18639 0.255813953488372 1.20772955396904 0.190720841755651 0.556571709815223 GO:0050660 flavin adenine dinucleotide binding 22/3948 86/18639 0.255813953488372 1.20772955396904 0.190720841755651 0.556571709815223 GO:0030170 pyridoxal phosphate binding 15/3948 56/18639 0.267857142857143 1.264586951802 0.191418764400725 0.556571709815223 GO:0016887 ATP hydrolysis activity 96/3948 417/18639 0.23021582733813 1.08687761037371 0.191517538013052 0.556571709815223 GO:0003924 GTPase activity 77/3948 331/18639 0.232628398791541 1.09826766086006 0.192020385390671 0.556817283126325 GO:0005178 integrin binding 39/3948 161/18639 0.242236024844721 1.14362646076007 0.195681453537269 0.557351626432975 GO:0004865 protein serine/threonine phosphatase inhibitor activity 5/3948 15/18639 0.333333333333333 1.57370820668693 0.195936340836027 0.557351626432975 GO:0005041 low-density lipoprotein particle receptor activity 5/3948 15/18639 0.333333333333333 1.57370820668693 0.195936340836027 0.557351626432975 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/3948 15/18639 0.333333333333333 1.57370820668693 0.195936340836027 0.557351626432975 GO:0050780 dopamine receptor binding 5/3948 15/18639 0.333333333333333 1.57370820668693 0.195936340836027 0.557351626432975 GO:0051371 muscle alpha-actinin binding 5/3948 15/18639 0.333333333333333 1.57370820668693 0.195936340836027 0.557351626432975 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 21/3948 82/18639 0.25609756097561 1.20906850025947 0.19607835331024 0.557351626432975 GO:0033549 MAP kinase phosphatase activity 21/3948 82/18639 0.25609756097561 1.20906850025947 0.19607835331024 0.557351626432975 GO:0001671 ATPase activator activity 8/3948 27/18639 0.296296296296296 1.39885173927727 0.196609096889987 0.557351626432975 GO:0000295 adenine nucleotide transmembrane transporter activity 7/3948 23/18639 0.304347826086957 1.43686401480111 0.198318215769841 0.557351626432975 GO:0005158 insulin receptor binding 7/3948 23/18639 0.304347826086957 1.43686401480111 0.198318215769841 0.557351626432975 GO:0008171 O-methyltransferase activity 7/3948 23/18639 0.304347826086957 1.43686401480111 0.198318215769841 0.557351626432975 GO:0031420 alkali metal ion binding 6/3948 19/18639 0.315789473684211 1.49088145896657 0.198485853440443 0.557351626432975 GO:0043395 heparan sulfate proteoglycan binding 6/3948 19/18639 0.315789473684211 1.49088145896657 0.198485853440443 0.557351626432975 GO:0046527 glucosyltransferase activity 6/3948 19/18639 0.315789473684211 1.49088145896657 0.198485853440443 0.557351626432975 GO:0140693 molecular condensate scaffold activity 13/3948 48/18639 0.270833333333333 1.27863791793313 0.201462226260492 0.564518364532032 GO:0016836 hydro-lyase activity 16/3948 61/18639 0.262295081967213 1.23832776919627 0.206056814830231 0.575385883172353 GO:0016248 channel inhibitor activity 12/3948 44/18639 0.272727272727273 1.28757944183476 0.206637454662949 0.575385883172353 GO:0043014 alpha-tubulin binding 12/3948 44/18639 0.272727272727273 1.28757944183476 0.206637454662949 0.575385883172353 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 11/3948 40/18639 0.275 1.29830927051672 0.211882285801553 0.586403207942437 GO:0015932 nucleobase-containing compound transmembrane transporter activity 15/3948 57/18639 0.263157894736842 1.24240121580547 0.211915809932616 0.586403207942437 GO:0070279 vitamin B6 binding 15/3948 57/18639 0.263157894736842 1.24240121580547 0.211915809932616 0.586403207942437 GO:0016409 palmitoyltransferase activity 10/3948 36/18639 0.277777777777778 1.31142350557244 0.21715200211644 0.599511180267217 GO:0051018 protein kinase A binding 14/3948 53/18639 0.264150943396226 1.24708952228021 0.218004065551715 0.599511180267217 GO:1901505 carbohydrate derivative transmembrane transporter activity 14/3948 53/18639 0.264150943396226 1.24708952228021 0.218004065551715 0.599511180267217 GO:0016835 carbon-oxygen lyase activity 20/3948 79/18639 0.253164556962025 1.1952214228002 0.219327293199251 0.60190644793444 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 43/3948 181/18639 0.237569060773481 1.1215931417824 0.22123467074254 0.605891659996545 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 32/3948 132/18639 0.242424242424242 1.14451505940868 0.221972275499591 0.606663447001964 GO:0016763 pentosyltransferase activity 13/3948 49/18639 0.26530612244898 1.25254326654674 0.224332808285101 0.61135652205655 GO:0046875 ephrin receptor binding 8/3948 28/18639 0.285714285714286 1.3488927485888 0.22742319581108 0.61135652205655 GO:0051019 mitogen-activated protein kinase binding 8/3948 28/18639 0.285714285714286 1.3488927485888 0.22742319581108 0.61135652205655 GO:0051393 alpha-actinin binding 8/3948 28/18639 0.285714285714286 1.3488927485888 0.22742319581108 0.61135652205655 GO:0000149 SNARE binding 26/3948 106/18639 0.245283018867925 1.15801169926019 0.230499255193459 0.61135652205655 GO:0017018 myosin phosphatase activity 21/3948 84/18639 0.25 1.1802811550152 0.230645447611938 0.61135652205655 GO:0141110 transporter inhibitor activity 12/3948 45/18639 0.266666666666667 1.25896656534954 0.230912457569779 0.61135652205655 GO:0035035 histone acetyltransferase binding 7/3948 24/18639 0.291666666666667 1.37699468085106 0.232090795646287 0.61135652205655 GO:0101005 deubiquitinase activity 28/3948 115/18639 0.243478260869565 1.14949121184089 0.232819091940827 0.61135652205655 GO:0016408 C-acyltransferase activity 6/3948 20/18639 0.3 1.41633738601824 0.235993651015071 0.61135652205655 GO:0003995 acyl-CoA dehydrogenase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0005025 transforming growth factor beta receptor activity, type I 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0005026 transforming growth factor beta receptor activity, type II 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0005165 neurotrophin receptor binding 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0016208 AMP binding 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0016273 arginine N-methyltransferase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0016274 protein-arginine N-methyltransferase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0016361 activin receptor activity, type I 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0016362 activin receptor activity, type II 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0016423 tRNA (guanine) methyltransferase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0017002 activin receptor activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0031543 peptidyl-proline dioxygenase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0035251 UDP-glucosyltransferase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0036009 protein-glutamine N-methyltransferase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0070008 serine-type exopeptidase activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:1990459 transferrin receptor binding 4/3948 12/18639 0.333333333333333 1.57370820668693 0.237656998932552 0.61135652205655 GO:0005159 insulin-like growth factor receptor binding 5/3948 16/18639 0.3125 1.475351443769 0.238387704693726 0.61135652205655 GO:0008142 oxysterol binding 5/3948 16/18639 0.3125 1.475351443769 0.238387704693726 0.61135652205655 GO:0015562 efflux transmembrane transporter activity 5/3948 16/18639 0.3125 1.475351443769 0.238387704693726 0.61135652205655 GO:0008234 cysteine-type peptidase activity 44/3948 187/18639 0.235294117647059 1.11085285177901 0.239335178667771 0.612606005397699 GO:0008173 RNA methyltransferase activity 17/3948 67/18639 0.253731343283582 1.19789729165722 0.240012272970057 0.613159952635597 GO:0005525 GTP binding 86/3948 378/18639 0.227513227513228 1.07411829980219 0.2428366742125 0.619186998806201 GO:0019213 deacetylase activity 10/3948 37/18639 0.27027027027027 1.27597962704346 0.244853449573035 0.623135643177266 GO:0019239 deaminase activity 9/3948 33/18639 0.272727272727273 1.28757944183476 0.25221392031447 0.639422338930589 GO:0140311 protein sequestering activity 9/3948 33/18639 0.272727272727273 1.28757944183476 0.25221392031447 0.639422338930589 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 12/3948 46/18639 0.260869565217391 1.23159772697238 0.256240100685796 0.648187431455178 GO:0001618 virus receptor activity 20/3948 81/18639 0.246913580246914 1.16570978273106 0.256645211402614 0.648187431455178 GO:0015399 primary active transmembrane transporter activity 39/3948 166/18639 0.234939759036145 1.10917988061669 0.258602083503099 0.651892752164063 GO:0140223 general transcription initiation factor activity 17/3948 68/18639 0.25 1.1802811550152 0.260924674116749 0.655403367752382 GO:1901681 sulfur compound binding 63/3948 275/18639 0.229090909090909 1.0815667311412 0.260979552899145 0.655403367752382 GO:0008374 O-acyltransferase activity 14/3948 55/18639 0.254545454545455 1.20174081237911 0.264035044990289 0.661827956463418 GO:0015297 antiporter activity 32/3948 135/18639 0.237037037037037 1.11908139142182 0.265504114614383 0.664259354420571 GO:0008139 nuclear localization sequence binding 7/3948 25/18639 0.28 1.32191489361702 0.267587533911626 0.664475760515624 GO:0017056 structural constituent of nuclear pore 7/3948 25/18639 0.28 1.32191489361702 0.267587533911626 0.664475760515624 GO:0019706 protein-cysteine S-palmitoyltransferase activity 7/3948 25/18639 0.28 1.32191489361702 0.267587533911626 0.664475760515624 GO:0019707 protein-cysteine S-acyltransferase activity 7/3948 25/18639 0.28 1.32191489361702 0.267587533911626 0.664475760515624 GO:0004536 DNA nuclease activity 16/3948 64/18639 0.25 1.1802811550152 0.269514397378075 0.668014269851429 GO:0042578 phosphoric ester hydrolase activity 82/3948 363/18639 0.225895316804408 1.06647994172172 0.272307311137929 0.673682213986214 GO:0004713 protein tyrosine kinase activity 33/3948 140/18639 0.235714285714286 1.11283651758576 0.273078777904931 0.674337390336666 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/3948 21/18639 0.285714285714286 1.3488927485888 0.2754158860082 0.677594351713336 GO:0005123 death receptor binding 6/3948 21/18639 0.285714285714286 1.3488927485888 0.2754158860082 0.677594351713336 GO:0140272 exogenous protein binding 20/3948 82/18639 0.24390243902439 1.15149380977092 0.276182907561444 0.678227767461774 GO:1990518 single-stranded 3'-5' DNA helicase activity 12/3948 47/18639 0.25531914893617 1.20539352001552 0.282481088764208 0.68800229229495 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/3948 17/18639 0.294117647058824 1.38856606472376 0.283005365395082 0.68800229229495 GO:0017110 nucleoside diphosphate phosphatase activity 5/3948 17/18639 0.294117647058824 1.38856606472376 0.283005365395082 0.68800229229495 GO:0019198 transmembrane receptor protein phosphatase activity 5/3948 17/18639 0.294117647058824 1.38856606472376 0.283005365395082 0.68800229229495 GO:0046965 nuclear retinoid X receptor binding 5/3948 17/18639 0.294117647058824 1.38856606472376 0.283005365395082 0.68800229229495 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 9/3948 34/18639 0.264705882352941 1.24970945825139 0.283264655279965 0.68800229229495 GO:0004518 nuclease activity 48/3948 209/18639 0.229665071770335 1.08427742470296 0.287375775967011 0.69215759100482 GO:0019842 vitamin binding 35/3948 150/18639 0.233333333333333 1.10159574468085 0.287593601204216 0.69215759100482 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0008417 fucosyltransferase activity 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0009982 pseudouridine synthase activity 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0019855 calcium channel inhibitor activity 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0051011 microtubule minus-end binding 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0070123 transforming growth factor beta receptor activity, type III 4/3948 13/18639 0.307692307692308 1.45265372924947 0.289655731171814 0.69215759100482 GO:0019843 rRNA binding 16/3948 65/18639 0.246153846153846 1.16212298339958 0.292077223257106 0.695446841064774 GO:0120013 lipid transfer activity 16/3948 65/18639 0.246153846153846 1.16212298339958 0.292077223257106 0.695446841064774 GO:0008375 acetylglucosaminyltransferase activity 11/3948 43/18639 0.255813953488372 1.20772955396904 0.292628122503784 0.695514341165245 GO:0008187 poly-pyrimidine tract binding 8/3948 30/18639 0.266666666666667 1.25896656534954 0.293464800087258 0.696259623736435 GO:0052689 carboxylic ester hydrolase activity 22/3948 92/18639 0.239130434782609 1.12896458305802 0.297176329705914 0.703810844908491 GO:0005080 protein kinase C binding 13/3948 52/18639 0.25 1.1802811550152 0.298506985049556 0.705706566786782 GO:0015026 coreceptor activity 15/3948 61/18639 0.245901639344262 1.16093228362151 0.302255450725332 0.713301427154994 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 10/3948 39/18639 0.256410256410256 1.21054477437456 0.303516146715298 0.714573322777851 GO:0050750 low-density lipoprotein particle receptor binding 7/3948 26/18639 0.269230769230769 1.27107201309329 0.304405014286282 0.714573322777851 GO:0097602 cullin family protein binding 7/3948 26/18639 0.269230769230769 1.27107201309329 0.304405014286282 0.714573322777851 GO:0016758 hexosyltransferase activity 45/3948 197/18639 0.228426395939086 1.07842948173977 0.309072512792146 0.721414532065343 GO:0016879 ligase activity, forming carbon-nitrogen bonds 12/3948 48/18639 0.25 1.1802811550152 0.309487376265447 0.721414532065343 GO:0036121 double-stranded DNA helicase activity 12/3948 48/18639 0.25 1.1802811550152 0.309487376265447 0.721414532065343 GO:0043138 3'-5' DNA helicase activity 12/3948 48/18639 0.25 1.1802811550152 0.309487376265447 0.721414532065343 GO:0035591 signaling adaptor activity 30/3948 129/18639 0.232558139534884 1.09793595815367 0.313394788559028 0.726829960007352 GO:0005154 epidermal growth factor receptor binding 9/3948 35/18639 0.257142857142857 1.21400347372992 0.315272723181756 0.726829960007352 GO:0008238 exopeptidase activity 24/3948 102/18639 0.235294117647059 1.11085285177901 0.316183490290263 0.726829960007352 GO:0008093 cytoskeletal anchor activity 6/3948 22/18639 0.272727272727273 1.28757944183476 0.316202272623111 0.726829960007352 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/3948 22/18639 0.272727272727273 1.28757944183476 0.316202272623111 0.726829960007352 GO:0070034 telomerase RNA binding 6/3948 22/18639 0.272727272727273 1.28757944183476 0.316202272623111 0.726829960007352 GO:0140517 protein-RNA adaptor activity 6/3948 22/18639 0.272727272727273 1.28757944183476 0.316202272623111 0.726829960007352 GO:0003725 double-stranded RNA binding 18/3948 75/18639 0.24 1.13306990881459 0.316310440429802 0.726829960007352 GO:0004527 exonuclease activity 20/3948 84/18639 0.238095238095238 1.12407729049066 0.316725301881491 0.726829960007352 GO:0070273 phosphatidylinositol-4-phosphate binding 8/3948 31/18639 0.258064516129032 1.21835474066085 0.328067354973308 0.745988967782144 GO:0070325 lipoprotein particle receptor binding 8/3948 31/18639 0.258064516129032 1.21835474066085 0.328067354973308 0.745988967782144 GO:0000400 four-way junction DNA binding 5/3948 18/18639 0.277777777777778 1.31142350557244 0.328997388495957 0.745988967782144 GO:0000900 mRNA regulatory element binding translation repressor activity 5/3948 18/18639 0.277777777777778 1.31142350557244 0.328997388495957 0.745988967782144 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/3948 18/18639 0.277777777777778 1.31142350557244 0.328997388495957 0.745988967782144 GO:0030228 lipoprotein particle receptor activity 5/3948 18/18639 0.277777777777778 1.31142350557244 0.328997388495957 0.745988967782144 GO:0098641 cadherin binding involved in cell-cell adhesion 5/3948 18/18639 0.277777777777778 1.31142350557244 0.328997388495957 0.745988967782144 GO:0071949 FAD binding 10/3948 40/18639 0.25 1.1802811550152 0.334060767019879 0.756181770243978 GO:0017116 single-stranded DNA helicase activity 14/3948 58/18639 0.241379310344828 1.13958180484226 0.338466908606442 0.758228544640726 GO:0004683 calcium/calmodulin-dependent protein kinase activity 7/3948 27/18639 0.259259259259259 1.22399527186761 0.342133585374985 0.758228544640726 GO:0005044 scavenger receptor activity 7/3948 27/18639 0.259259259259259 1.22399527186761 0.342133585374985 0.758228544640726 GO:0008266 poly(U) RNA binding 7/3948 27/18639 0.259259259259259 1.22399527186761 0.342133585374985 0.758228544640726 GO:0015252 proton channel activity 7/3948 27/18639 0.259259259259259 1.22399527186761 0.342133585374985 0.758228544640726 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 7/3948 27/18639 0.259259259259259 1.22399527186761 0.342133585374985 0.758228544640726 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7/3948 27/18639 0.259259259259259 1.22399527186761 0.342133585374985 0.758228544640726 GO:0030983 mismatched DNA binding 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:0032454 histone H3K9 demethylase activity 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:0042043 neurexin family protein binding 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:0042813 Wnt receptor activity 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:0071933 Arp2/3 complex binding 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:0098821 BMP receptor activity 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:1901612 cardiolipin binding 4/3948 14/18639 0.285714285714286 1.3488927485888 0.342940333488893 0.758228544640726 GO:0005507 copper ion binding 15/3948 63/18639 0.238095238095238 1.12407729049066 0.35110017812928 0.758933830753688 GO:0005539 glycosaminoglycan binding 54/3948 242/18639 0.223140495867769 1.0534740887739 0.356542575640056 0.758933830753688 GO:0003887 DNA-directed DNA polymerase activity 6/3948 23/18639 0.260869565217391 1.23159772697238 0.35780841033603 0.758933830753688 GO:0042171 lysophosphatidic acid acyltransferase activity 6/3948 23/18639 0.260869565217391 1.23159772697238 0.35780841033603 0.758933830753688 GO:0071617 lysophospholipid acyltransferase activity 6/3948 23/18639 0.260869565217391 1.23159772697238 0.35780841033603 0.758933830753688 GO:0000182 rDNA binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0001094 TFIID-class transcription factor complex binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0004090 carbonyl reductase (NADPH) activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0005131 growth hormone receptor binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0005381 iron ion transmembrane transporter activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0015187 glycine transmembrane transporter activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0016427 tRNA (cytidine) methyltransferase activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0030957 Tat protein binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0031434 mitogen-activated protein kinase kinase binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0033204 ribonuclease P RNA binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0035374 chondroitin sulfate binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0050308 sugar-phosphatase activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0051864 histone H3K36 demethylase activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0070513 death domain binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0140135 mechanosensitive monoatomic cation channel activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0141109 transporter activator activity 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:1990763 arrestin family protein binding 3/3948 10/18639 0.3 1.41633738601824 0.358084482128712 0.758933830753688 GO:0033218 amide binding 55/3948 247/18639 0.222672064777328 1.05126256722001 0.361335245507914 0.76390305583047 GO:0032934 sterol binding 16/3948 68/18639 0.235294117647059 1.11085285177901 0.362745599020666 0.76390305583047 GO:0043425 bHLH transcription factor binding 8/3948 32/18639 0.25 1.1802811550152 0.363298748565505 0.76390305583047 GO:0071813 lipoprotein particle binding 8/3948 32/18639 0.25 1.1802811550152 0.363298748565505 0.76390305583047 GO:0071814 protein-lipid complex binding 8/3948 32/18639 0.25 1.1802811550152 0.363298748565505 0.76390305583047 GO:0016877 ligase activity, forming carbon-sulfur bonds 10/3948 41/18639 0.24390243902439 1.15149380977092 0.365128318572978 0.766539104133492 GO:0003756 protein disulfide isomerase activity 5/3948 19/18639 0.263157894736842 1.24240121580547 0.375608651015783 0.782371071208148 GO:0008381 mechanosensitive monoatomic ion channel activity 5/3948 19/18639 0.263157894736842 1.24240121580547 0.375608651015783 0.782371071208148 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/3948 19/18639 0.263157894736842 1.24240121580547 0.375608651015783 0.782371071208148 GO:0070003 threonine-type peptidase activity 5/3948 19/18639 0.263157894736842 1.24240121580547 0.375608651015783 0.782371071208148 GO:0120227 acyl-CoA binding 5/3948 19/18639 0.263157894736842 1.24240121580547 0.375608651015783 0.782371071208148 GO:0016757 glycosyltransferase activity 59/3948 267/18639 0.220973782771536 1.04324476623066 0.379686666616487 0.789629614478975 GO:0051959 dynein light intermediate chain binding 7/3948 28/18639 0.25 1.1802811550152 0.380370381896287 0.789817438851728 GO:0061134 peptidase regulator activity 50/3948 226/18639 0.221238938053097 1.04449659735858 0.389294977866283 0.807089743831811 GO:0001540 amyloid-beta binding 19/3948 83/18639 0.228915662650602 1.08073937085729 0.393025464797097 0.811855810455364 GO:0004129 cytochrome-c oxidase activity 4/3948 15/18639 0.266666666666667 1.25896656534954 0.396396330817207 0.811855810455364 GO:0008242 omega peptidase activity 4/3948 15/18639 0.266666666666667 1.25896656534954 0.396396330817207 0.811855810455364 GO:0050700 CARD domain binding 4/3948 15/18639 0.266666666666667 1.25896656534954 0.396396330817207 0.811855810455364 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/3948 15/18639 0.266666666666667 1.25896656534954 0.396396330817207 0.811855810455364 GO:0141050 histone H3K deacetylase activity 4/3948 15/18639 0.266666666666667 1.25896656534954 0.396396330817207 0.811855810455364 GO:0141051 histone H4K deacetylase activity 4/3948 15/18639 0.266666666666667 1.25896656534954 0.396396330817207 0.811855810455364 GO:0004520 DNA endonuclease activity 10/3948 42/18639 0.238095238095238 1.12407729049066 0.396505117382839 0.811855810455364 GO:0003678 DNA helicase activity 17/3948 74/18639 0.22972972972973 1.08458268298694 0.397083495572083 0.811855810455364 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/3948 24/18639 0.25 1.1802811550152 0.399714281899277 0.812243830851814 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/3948 24/18639 0.25 1.1802811550152 0.399714281899277 0.812243830851814 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/3948 24/18639 0.25 1.1802811550152 0.399714281899277 0.812243830851814 GO:0070300 phosphatidic acid binding 6/3948 24/18639 0.25 1.1802811550152 0.399714281899277 0.812243830851814 GO:0003774 cytoskeletal motor activity 34/3948 153/18639 0.222222222222222 1.04913880445795 0.407166351631457 0.826125631130289 GO:0019001 guanyl nucleotide binding 87/3948 400/18639 0.2175 1.02684460486322 0.408936076823522 0.826863526315359 GO:0032561 guanyl ribonucleotide binding 87/3948 400/18639 0.2175 1.02684460486322 0.408936076823522 0.826863526315359 GO:0001784 phosphotyrosine residue binding 11/3948 47/18639 0.234042553191489 1.10494406001423 0.410014971726624 0.826863526315359 GO:0061749 forked DNA-dependent helicase activity 11/3948 47/18639 0.234042553191489 1.10494406001423 0.410014971726624 0.826863526315359 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 14/3948 61/18639 0.229508196721311 1.08353679804674 0.416547846209634 0.827507564313681 GO:0043236 laminin binding 7/3948 29/18639 0.241379310344828 1.13958180484226 0.418730263244781 0.827507564313681 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0008046 axon guidance receptor activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0015173 aromatic amino acid transmembrane transporter activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0019206 nucleoside kinase activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0034713 type I transforming growth factor beta receptor binding 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0097493 structural molecule activity conferring elasticity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0180030 inositol phosphate kinase activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:1990948 ubiquitin ligase inhibitor activity 3/3948 11/18639 0.272727272727273 1.28757944183476 0.421797756617103 0.827507564313681 GO:0016004 phospholipase activator activity 5/3948 20/18639 0.25 1.1802811550152 0.422146984349353 0.827507564313681 GO:0030742 GTP-dependent protein binding 5/3948 20/18639 0.25 1.1802811550152 0.422146984349353 0.827507564313681 GO:0042288 MHC class I protein binding 5/3948 20/18639 0.25 1.1802811550152 0.422146984349353 0.827507564313681 GO:0052745 inositol phosphate phosphatase activity 5/3948 20/18639 0.25 1.1802811550152 0.422146984349353 0.827507564313681 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 10/3948 43/18639 0.232558139534884 1.09793595815367 0.427982994618916 0.837713773290848 GO:0008175 tRNA methyltransferase activity 8/3948 34/18639 0.235294117647059 1.11085285177901 0.434409351552259 0.846557608954695 GO:0052866 phosphatidylinositol phosphate phosphatase activity 8/3948 34/18639 0.235294117647059 1.11085285177901 0.434409351552259 0.846557608954695 GO:0090482 vitamin transmembrane transporter activity 8/3948 34/18639 0.235294117647059 1.11085285177901 0.434409351552259 0.846557608954695 GO:0009378 four-way junction helicase activity 11/3948 48/18639 0.229166666666667 1.08192439209726 0.439901554161028 0.856007264018024 GO:0017025 TBP-class protein binding 6/3948 25/18639 0.24 1.13306990881459 0.441438518105904 0.856493684546586 GO:0120020 cholesterol transfer activity 6/3948 25/18639 0.24 1.13306990881459 0.441438518105904 0.856493684546586 GO:0000062 fatty-acyl-CoA binding 4/3948 16/18639 0.25 1.1802811550152 0.449065872858368 0.864987954811126 GO:0003688 DNA replication origin binding 4/3948 16/18639 0.25 1.1802811550152 0.449065872858368 0.864987954811126 GO:0004707 MAP kinase activity 4/3948 16/18639 0.25 1.1802811550152 0.449065872858368 0.864987954811126 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/3948 16/18639 0.25 1.1802811550152 0.449065872858368 0.864987954811126 GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/3948 16/18639 0.25 1.1802811550152 0.449065872858368 0.864987954811126 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 15/3948 67/18639 0.223880597014925 1.05696819852107 0.451919049592357 0.869225802033855 GO:0001965 G-protein alpha-subunit binding 7/3948 30/18639 0.233333333333333 1.10159574468085 0.456854534640549 0.874925734685713 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/3948 30/18639 0.233333333333333 1.10159574468085 0.456854534640549 0.874925734685713 GO:0051721 protein phosphatase 2A binding 7/3948 30/18639 0.233333333333333 1.10159574468085 0.456854534640549 0.874925734685713 GO:0061980 regulatory RNA binding 13/3948 58/18639 0.224137931034483 1.05818310449638 0.460212137002662 0.880089589584113 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/3948 21/18639 0.238095238095238 1.12407729049066 0.468000452580964 0.889869431978948 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/3948 21/18639 0.238095238095238 1.12407729049066 0.468000452580964 0.889869431978948 GO:0009975 cyclase activity 5/3948 21/18639 0.238095238095238 1.12407729049066 0.468000452580964 0.889869431978948 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/3948 21/18639 0.238095238095238 1.12407729049066 0.468000452580964 0.889869431978948 GO:1901682 sulfur compound transmembrane transporter activity 14/3948 63/18639 0.222222222222222 1.04913880445795 0.469031047413883 0.890556810424934 GO:0034061 DNA polymerase activity 8/3948 35/18639 0.228571428571429 1.07911419887104 0.469709093291667 0.890573793691181 GO:0005548 phospholipid transporter activity 15/3948 68/18639 0.220588235294118 1.04142454854282 0.477156818622081 0.893208236412144 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 12/3948 54/18639 0.222222222222222 1.04913880445795 0.478914681501825 0.893208236412144 GO:0004532 RNA exonuclease activity 9/3948 40/18639 0.225 1.06225303951368 0.480754189547446 0.893208236412144 GO:0061791 GTPase motor activity 9/3948 40/18639 0.225 1.06225303951368 0.480754189547446 0.893208236412144 GO:1990606 membrane scission GTPase motor activity 9/3948 40/18639 0.225 1.06225303951368 0.480754189547446 0.893208236412144 GO:0030507 spectrin binding 6/3948 26/18639 0.230769230769231 1.08949029693711 0.482548569251791 0.893208236412144 GO:0000995 RNA polymerase III general transcription initiation factor activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0004000 adenosine deaminase activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0004526 ribonuclease P activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0005078 MAP-kinase scaffold activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0005247 voltage-gated chloride channel activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0008179 adenylate cyclase binding 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0045295 gamma-catenin binding 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0097371 MDM2/MDM4 family protein binding 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0140829 bicarbonate:monoatomic anion antiporter activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0140900 chloride:bicarbonate antiporter activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:1990817 poly(A) RNA polymerase activity 3/3948 12/18639 0.25 1.1802811550152 0.483178009178621 0.893208236412144 GO:0036002 pre-mRNA binding 13/3948 59/18639 0.220338983050847 1.04024779764051 0.487331995291965 0.899329324597916 GO:0008201 heparin binding 37/3948 172/18639 0.215116279069767 1.01559076129215 0.487840550232679 0.899329324597916 GO:0005452 solute:inorganic anion antiporter activity 7/3948 31/18639 0.225806451612903 1.06606039807824 0.494417462043494 0.908935969585483 GO:0017147 Wnt-protein binding 7/3948 31/18639 0.225806451612903 1.06606039807824 0.494417462043494 0.908935969585483 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0004549 tRNA-specific ribonuclease activity 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0016018 cyclosporin A binding 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0031489 myosin V binding 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0051787 misfolded protein binding 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0070403 NAD+ binding 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0070492 oligosaccharide binding 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:1901567 fatty acid derivative binding 4/3948 17/18639 0.235294117647059 1.11085285177901 0.500161413616302 0.909446504813249 GO:0004540 RNA nuclease activity 26/3948 121/18639 0.214876033057851 1.01445652993042 0.503033405828827 0.91342082286244 GO:0045505 dynein intermediate chain binding 8/3948 36/18639 0.222222222222222 1.04913880445795 0.504488939888278 0.914815775192504 GO:0004407 histone deacetylase activity 5/3948 22/18639 0.227272727272727 1.07298286819563 0.512646976097979 0.923319519873357 GO:0008649 rRNA methyltransferase activity 5/3948 22/18639 0.227272727272727 1.07298286819563 0.512646976097979 0.923319519873357 GO:0015377 chloride:monoatomic cation symporter activity 5/3948 22/18639 0.227272727272727 1.07298286819563 0.512646976097979 0.923319519873357 GO:0016881 acid-amino acid ligase activity 5/3948 22/18639 0.227272727272727 1.07298286819563 0.512646976097979 0.923319519873357 GO:0033558 protein lysine deacetylase activity 5/3948 22/18639 0.227272727272727 1.07298286819563 0.512646976097979 0.923319519873357 GO:0160215 deacylase activity 14/3948 65/18639 0.215384615384615 1.01685761047463 0.520803182329608 0.936741940109065 GO:0008320 protein transmembrane transporter activity 6/3948 27/18639 0.222222222222222 1.04913880445795 0.522667136073735 0.938825854405048 GO:0004857 enzyme inhibitor activity 88/3948 416/18639 0.211538461538462 0.998699438859013 0.525302772591056 0.941756951983595 GO:0004843 cysteine-type deubiquitinase activity 23/3948 108/18639 0.212962962962963 1.00542468760554 0.52642161703666 0.941756951983595 GO:0005496 steroid binding 23/3948 108/18639 0.212962962962963 1.00542468760554 0.52642161703666 0.941756951983595 GO:0016830 carbon-carbon lyase activity 11/3948 51/18639 0.215686274509804 1.01828178079743 0.528162136264354 0.943602420627994 GO:0022884 macromolecule transmembrane transporter activity 7/3948 32/18639 0.21875 1.0327460106383 0.531130701817331 0.946365413813745 GO:0120015 sterol transfer activity 7/3948 32/18639 0.21875 1.0327460106383 0.531130701817331 0.946365413813745 GO:0019905 syntaxin binding 13/3948 61/18639 0.213114754098361 1.00614131247197 0.540604229906211 0.94787286292745 GO:0002161 aminoacyl-tRNA editing activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0004535 poly(A)-specific ribonuclease activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0005172 vascular endothelial growth factor receptor binding 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0008035 high-density lipoprotein particle binding 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0008253 5'-nucleotidase activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0035325 Toll-like receptor binding 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0035673 oligopeptide transmembrane transporter activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0039706 co-receptor binding 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0046974 histone H3K9 methyltransferase activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0070700 BMP receptor binding 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0071714 icosanoid transmembrane transporter activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/3948 13/18639 0.230769230769231 1.08949029693711 0.541234692580663 0.94787286292745 GO:0019894 kinesin binding 9/3948 42/18639 0.214285714285714 1.0116695614416 0.545120015316154 0.949098798800269 GO:0031492 nucleosomal DNA binding 9/3948 42/18639 0.214285714285714 1.0116695614416 0.545120015316154 0.949098798800269 GO:0035198 miRNA binding 9/3948 42/18639 0.214285714285714 1.0116695614416 0.545120015316154 0.949098798800269 GO:0008235 metalloexopeptidase activity 14/3948 66/18639 0.212121212121212 1.00145067698259 0.546167962097428 0.949098798800269 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/3948 18/18639 0.222222222222222 1.04913880445795 0.549065420793544 0.949098798800269 GO:0004706 JUN kinase kinase kinase activity 4/3948 18/18639 0.222222222222222 1.04913880445795 0.549065420793544 0.949098798800269 GO:0008308 voltage-gated monoatomic anion channel activity 4/3948 18/18639 0.222222222222222 1.04913880445795 0.549065420793544 0.949098798800269 GO:0008525 phosphatidylcholine transporter activity 4/3948 18/18639 0.222222222222222 1.04913880445795 0.549065420793544 0.949098798800269 GO:0031690 adrenergic receptor binding 4/3948 18/18639 0.222222222222222 1.04913880445795 0.549065420793544 0.949098798800269 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/3948 18/18639 0.222222222222222 1.04913880445795 0.549065420793544 0.949098798800269 GO:0017134 fibroblast growth factor binding 5/3948 23/18639 0.217391304347826 1.02633143914365 0.555657688809633 0.956766343862381 GO:0140102 catalytic activity, acting on a rRNA 5/3948 23/18639 0.217391304347826 1.02633143914365 0.555657688809633 0.956766343862381 GO:0140103 catalytic activity, acting on a glycoprotein 5/3948 23/18639 0.217391304347826 1.02633143914365 0.555657688809633 0.956766343862381 GO:0000146 microfilament motor activity 8/3948 38/18639 0.210526315789474 0.993920972644377 0.571601294375359 0.9816791262111 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 8/3948 38/18639 0.210526315789474 0.993920972644377 0.571601294375359 0.9816791262111 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 27/3948 130/18639 0.207692307692308 0.980541267243395 0.580587860639412 0.995827889833837 GO:0005246 calcium channel regulator activity 11/3948 53/18639 0.207547169811321 0.979856053220164 0.584408107057232 0.998995740833844 GO:0005161 platelet-derived growth factor receptor binding 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:0015926 glucosidase activity 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:0019992 diacylglycerol binding 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:0031404 chloride ion binding 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:0046030 inositol trisphosphate phosphatase activity 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:0098847 sequence-specific single stranded DNA binding 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:1901474 azole transmembrane transporter activity 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:1990825 sequence-specific mRNA binding 3/3948 14/18639 0.214285714285714 1.0116695614416 0.595314972332964 0.998995740833844 GO:0008301 DNA binding, bending 4/3948 19/18639 0.210526315789474 0.993920972644377 0.595320559400947 0.998995740833844 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/3948 19/18639 0.210526315789474 0.993920972644377 0.595320559400947 0.998995740833844 GO:0046624 sphingolipid transporter activity 4/3948 19/18639 0.210526315789474 0.993920972644377 0.595320559400947 0.998995740833844 GO:0097001 ceramide binding 4/3948 19/18639 0.210526315789474 0.993920972644377 0.595320559400947 0.998995740833844 GO:1990380 K48-linked deubiquitinase activity 4/3948 19/18639 0.210526315789474 0.993920972644377 0.595320559400947 0.998995740833844 GO:0003777 microtubule motor activity 14/3948 68/18639 0.205882352941176 0.971996245306633 0.595410181930948 0.998995740833844 GO:0015295 solute:proton symporter activity 5/3948 24/18639 0.208333333333333 0.983567629179331 0.596695427470252 0.998995740833844 GO:0050699 WW domain binding 5/3948 24/18639 0.208333333333333 0.983567629179331 0.596695427470252 0.998995740833844 GO:0060229 lipase activator activity 5/3948 24/18639 0.208333333333333 0.983567629179331 0.596695427470252 0.998995740833844 GO:0140612 DNA damage sensor activity 5/3948 24/18639 0.208333333333333 0.983567629179331 0.596695427470252 0.998995740833844 GO:0008237 metallopeptidase activity 38/3948 184/18639 0.206521739130435 0.975014867186468 0.599141852628366 1 GO:0008376 acetylgalactosaminyltransferase activity 7/3948 34/18639 0.205882352941176 0.971996245306633 0.601055303103055 1 GO:0016831 carboxy-lyase activity 7/3948 34/18639 0.205882352941176 0.971996245306633 0.601055303103055 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/3948 34/18639 0.205882352941176 0.971996245306633 0.601055303103055 1 GO:0019199 transmembrane receptor protein kinase activity 16/3948 78/18639 0.205128205128205 0.968435819499649 0.602043305599067 1 GO:0030165 PDZ domain binding 17/3948 83/18639 0.204819277108434 0.96697733181968 0.605190921127682 1 GO:0016790 thiolester hydrolase activity 9/3948 44/18639 0.204545454545455 0.965684581376071 0.606151922941636 1 GO:0004519 endonuclease activity 26/3948 127/18639 0.204724409448819 0.966529449776225 0.612573213546182 1 GO:0042277 peptide binding 51/3948 249/18639 0.204819277108434 0.96697733181968 0.631947703411105 1 GO:0000175 3'-5'-RNA exonuclease activity 7/3948 35/18639 0.2 0.944224924012158 0.633891855555902 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 6/3948 30/18639 0.2 0.944224924012158 0.634177851748973 1 GO:0046915 transition metal ion transmembrane transporter activity 9/3948 45/18639 0.2 0.944224924012158 0.635075578241652 1 GO:0005537 D-mannose binding 5/3948 25/18639 0.2 0.944224924012158 0.635509654811339 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 5/3948 25/18639 0.2 0.944224924012158 0.635509654811339 1 GO:0019211 phosphatase activator activity 5/3948 25/18639 0.2 0.944224924012158 0.635509654811339 1 GO:0001972 retinoic acid binding 4/3948 20/18639 0.2 0.944224924012158 0.638613953163845 1 GO:0015095 magnesium ion transmembrane transporter activity 4/3948 20/18639 0.2 0.944224924012158 0.638613953163845 1 GO:0140664 ATP-dependent DNA damage sensor activity 4/3948 20/18639 0.2 0.944224924012158 0.638613953163845 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 12/3948 60/18639 0.2 0.944224924012158 0.638961758328579 1 GO:0044183 protein folding chaperone 15/3948 75/18639 0.2 0.944224924012158 0.643871017854055 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0005523 tropomyosin binding 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0008252 nucleotidase activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0010181 FMN binding 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0016846 carbon-sulfur lyase activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0034483 heparan sulfate sulfotransferase activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0045504 dynein heavy chain binding 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0140161 monocarboxylate:sodium symporter activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0140776 protein-containing complex destabilizing activity 3/3948 15/18639 0.2 0.944224924012158 0.645044632711903 1 GO:0035401 histone H3Y41 kinase activity 23/3948 115/18639 0.2 0.944224924012158 0.658064477086951 1 GO:0140801 histone H2AXY142 kinase activity 23/3948 115/18639 0.2 0.944224924012158 0.658064477086951 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0004382 GDP phosphatase activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0005031 tumor necrosis factor receptor activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0008190 eukaryotic initiation factor 4E binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0015203 polyamine transmembrane transporter activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0015643 toxic substance binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0019911 structural constituent of myelin sheath 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0031419 cobalamin binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0032356 oxidized DNA binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0035256 G protein-coupled glutamate receptor binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0043295 glutathione binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0051880 G-quadruplex DNA binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0070097 delta-catenin binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0098505 G-rich strand telomeric DNA binding 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/3948 10/18639 0.2 0.944224924012158 0.65887378533303 1 GO:0004812 aminoacyl-tRNA ligase activity 8/3948 41/18639 0.195121951219512 0.92119504781674 0.663597018973145 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 8/3948 41/18639 0.195121951219512 0.92119504781674 0.663597018973145 1 GO:0017022 myosin binding 15/3948 76/18639 0.197368421052632 0.931800911854103 0.665405225962318 1 GO:0030971 receptor tyrosine kinase binding 16/3948 81/18639 0.197530864197531 0.932567826184847 0.6664430704303 1 GO:0008194 UDP-glycosyltransferase activity 29/3948 145/18639 0.2 0.944224924012158 0.668505942315328 1 GO:0004529 DNA exonuclease activity 5/3948 26/18639 0.192307692307692 0.907908580780921 0.671928960896946 1 GO:0005160 transforming growth factor beta receptor binding 5/3948 26/18639 0.192307692307692 0.907908580780921 0.671928960896946 1 GO:0051139 metal cation:proton antiporter activity 5/3948 26/18639 0.192307692307692 0.907908580780921 0.671928960896946 1 GO:0070412 R-SMAD binding 5/3948 26/18639 0.192307692307692 0.907908580780921 0.671928960896946 1 GO:0070182 DNA polymerase binding 4/3948 21/18639 0.19047619047619 0.899261832392531 0.67875830624217 1 GO:0072542 protein phosphatase activator activity 4/3948 21/18639 0.19047619047619 0.899261832392531 0.67875830624217 1 GO:1904047 S-adenosyl-L-methionine binding 4/3948 21/18639 0.19047619047619 0.899261832392531 0.67875830624217 1 GO:0030159 signaling receptor complex adaptor activity 10/3948 52/18639 0.192307692307692 0.907908580780921 0.687744293806087 1 GO:0043178 alcohol binding 18/3948 92/18639 0.195652173913043 0.923698295229285 0.687761246747504 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0015378 sodium:chloride symporter activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0015385 sodium:proton antiporter activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0016722 oxidoreductase activity, acting on metal ions 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0022858 alanine transmembrane transporter activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0070411 I-SMAD binding 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0140327 flippase activity 3/3948 16/18639 0.1875 0.885210866261398 0.690270500370411 1 GO:0008307 structural constituent of muscle 8/3948 42/18639 0.19047619047619 0.899261832392531 0.691473961010083 1 GO:0004175 endopeptidase activity 82/3948 405/18639 0.202469135802469 0.955882021839469 0.69795959781738 1 GO:0005385 zinc ion transmembrane transporter activity 5/3948 27/18639 0.185185185185185 0.874282337048295 0.705852102902222 1 GO:0035255 ionotropic glutamate receptor binding 5/3948 27/18639 0.185185185185185 0.874282337048295 0.705852102902222 1 GO:0004521 RNA endonuclease activity 14/3948 73/18639 0.191780821917808 0.905421160011658 0.706678992534009 1 GO:0030145 manganese ion binding 13/3948 68/18639 0.191176470588235 0.902567942070445 0.707376187256241 1 GO:0008408 3'-5' exonuclease activity 11/3948 58/18639 0.189655172413793 0.895385703804633 0.709832141780378 1 GO:0000099 sulfur amino acid transmembrane transporter activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0004016 adenylate cyclase activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0008172 S-methyltransferase activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0008199 ferric iron binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0008432 JUN kinase binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0008503 benzodiazepine receptor activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0019864 IgG binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0032404 mismatch repair complex binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0035252 UDP-xylosyltransferase activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0042285 xylosyltransferase activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0047676 arachidonate-CoA ligase activity 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0050998 nitric-oxide synthase binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0070990 snRNP binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:1900750 oligopeptide binding 2/3948 11/18639 0.181818181818182 0.858386294556507 0.711557347269903 1 GO:0031683 G-protein beta/gamma-subunit complex binding 4/3948 22/18639 0.181818181818182 0.858386294556507 0.715671935163102 1 GO:0005109 frizzled binding 7/3948 38/18639 0.184210526315789 0.86968085106383 0.722458173746204 1 GO:0042887 amide transmembrane transporter activity 7/3948 38/18639 0.184210526315789 0.86968085106383 0.722458173746204 1 GO:0005506 iron ion binding 30/3948 154/18639 0.194805194805195 0.919699601310544 0.72769790569272 1 GO:0019956 chemokine binding 6/3948 33/18639 0.181818181818182 0.858386294556507 0.728684407728851 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/3948 17/18639 0.176470588235294 0.833139638834257 0.73100816181772 1 GO:0001786 phosphatidylserine binding 11/3948 59/18639 0.186440677966102 0.880209674926588 0.731793077635624 1 GO:0070888 E-box binding 11/3948 59/18639 0.186440677966102 0.880209674926588 0.731793077635624 1 GO:0015485 cholesterol binding 10/3948 54/18639 0.185185185185185 0.874282337048295 0.734589866921995 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 10/3948 54/18639 0.185185185185185 0.874282337048295 0.734589866921995 1 GO:0050698 proteoglycan sulfotransferase activity 5/3948 28/18639 0.178571428571429 0.843057967867998 0.737238355324771 1 GO:0035254 glutamate receptor binding 9/3948 49/18639 0.183673469387755 0.867145338378513 0.738138175926161 1 GO:0000217 DNA secondary structure binding 7/3948 39/18639 0.179487179487179 0.847381342062193 0.748466407445058 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/3948 23/18639 0.173913043478261 0.82106515131492 0.749359144921727 1 GO:0016849 phosphorus-oxygen lyase activity 4/3948 23/18639 0.173913043478261 0.82106515131492 0.749359144921727 1 GO:0005262 calcium channel activity 25/3948 131/18639 0.190839694656489 0.900977980927632 0.753692999160053 1 GO:0003720 telomerase activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0004032 aldose reductase (NADPH) activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0004126 cytidine deaminase activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0004875 complement receptor activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0005049 nuclear export signal receptor activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0015132 prostaglandin transmembrane transporter activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0015368 calcium:monoatomic cation antiporter activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0016801 hydrolase activity, acting on ether bonds 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0016803 ether hydrolase activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0043047 single-stranded telomeric DNA binding 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0070410 co-SMAD binding 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/3948 12/18639 0.166666666666667 0.786854103343465 0.757233214888159 1 GO:0032813 tumor necrosis factor receptor superfamily binding 9/3948 50/18639 0.18 0.849802431610942 0.760518538232175 1 GO:0015101 organic cation transmembrane transporter activity 15/3948 81/18639 0.185185185185185 0.874282337048295 0.76154450314983 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 8/3948 45/18639 0.177777777777778 0.839311043566363 0.765919504561982 1 GO:0035250 UDP-galactosyltransferase activity 5/3948 29/18639 0.172413793103448 0.813987003458757 0.766097765115914 1 GO:0015085 calcium ion transmembrane transporter activity 28/3948 147/18639 0.19047619047619 0.899261832392531 0.766711314569418 1 GO:0015373 monoatomic anion:sodium symporter activity 3/3948 18/18639 0.166666666666667 0.786854103343465 0.767396710022555 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/3948 18/18639 0.166666666666667 0.786854103343465 0.767396710022555 1 GO:0017128 phospholipid scramblase activity 3/3948 18/18639 0.166666666666667 0.786854103343465 0.767396710022555 1 GO:0050811 GABA receptor binding 3/3948 18/18639 0.166666666666667 0.786854103343465 0.767396710022555 1 GO:1990782 protein tyrosine kinase binding 22/3948 117/18639 0.188034188034188 0.887732834541345 0.768881594578289 1 GO:0016247 channel regulator activity 32/3948 168/18639 0.19047619047619 0.899261832392531 0.778617876111342 1 GO:0004806 triacylglycerol lipase activity 4/3948 24/18639 0.166666666666667 0.786854103343465 0.779891888412021 1 GO:0005315 phosphate transmembrane transporter activity 4/3948 24/18639 0.166666666666667 0.786854103343465 0.779891888412021 1 GO:0005540 hyaluronic acid binding 4/3948 24/18639 0.166666666666667 0.786854103343465 0.779891888412021 1 GO:0004180 carboxypeptidase activity 8/3948 46/18639 0.173913043478261 0.82106515131492 0.787628679522758 1 GO:0015179 L-amino acid transmembrane transporter activity 11/3948 62/18639 0.17741935483871 0.837618884204334 0.790918389066837 1 GO:0033612 receptor serine/threonine kinase binding 5/3948 30/18639 0.166666666666667 0.786854103343465 0.792481747789302 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/3948 41/18639 0.170731707317073 0.806045666839647 0.795151286418714 1 GO:0017080 sodium channel regulator activity 7/3948 41/18639 0.170731707317073 0.806045666839647 0.795151286418714 1 GO:0140828 metal cation:monoatomic cation antiporter activity 7/3948 41/18639 0.170731707317073 0.806045666839647 0.795151286418714 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0003964 RNA-directed DNA polymerase activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0005035 death receptor activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0031432 titin binding 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0043560 insulin receptor substrate binding 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0045159 myosin II binding 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0089720 caspase binding 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0140666 annealing activity 2/3948 13/18639 0.153846153846154 0.726326864624737 0.796505673489522 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0008574 plus-end-directed microtubule motor activity 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0015245 fatty acid transmembrane transporter activity 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0022821 solute:potassium antiporter activity 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0030506 ankyrin binding 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0034987 immunoglobulin receptor binding 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0042577 lipid phosphatase activity 3/3948 19/18639 0.157894736842105 0.745440729483283 0.799660988264107 1 GO:0003735 structural constituent of ribosome 33/3948 175/18639 0.188571428571429 0.890269214068606 0.800706887324755 1 GO:0141108 transporter regulator activity 32/3948 170/18639 0.188235294117647 0.888682281423208 0.801014881233175 1 GO:0042562 hormone binding 17/3948 94/18639 0.180851063829787 0.853820410010994 0.804287633039963 1 GO:0004033 aldo-keto reductase (NADPH) activity 6/3948 36/18639 0.166666666666667 0.786854103343465 0.80453961593388 1 GO:0004190 aspartic-type endopeptidase activity 6/3948 36/18639 0.166666666666667 0.786854103343465 0.80453961593388 1 GO:0015662 P-type ion transporter activity 4/3948 25/18639 0.16 0.755379939209726 0.807393266240722 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/3948 25/18639 0.16 0.755379939209726 0.807393266240722 1 GO:0140358 P-type transmembrane transporter activity 4/3948 25/18639 0.16 0.755379939209726 0.807393266240722 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 95/3948 484/18639 0.196280991735537 0.926667022532593 0.816460573400886 1 GO:0016878 acid-thiol ligase activity 5/3948 31/18639 0.161290322580645 0.761471712913031 0.816474325195267 1 GO:0047499 calcium-independent phospholipase A2 activity 5/3948 31/18639 0.161290322580645 0.761471712913031 0.816474325195267 1 GO:0072349 modified amino acid transmembrane transporter activity 5/3948 31/18639 0.161290322580645 0.761471712913031 0.816474325195267 1 GO:0070001 aspartic-type peptidase activity 6/3948 37/18639 0.162162162162162 0.765587776226074 0.82580494509548 1 GO:0001614 purinergic nucleotide receptor activity 3/3948 20/18639 0.15 0.708168693009119 0.8280810532818 1 GO:0016502 nucleotide receptor activity 3/3948 20/18639 0.15 0.708168693009119 0.8280810532818 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/3948 20/18639 0.15 0.708168693009119 0.8280810532818 1 GO:0004705 JUN kinase activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0008191 metalloendopeptidase inhibitor activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0008195 phosphatidate phosphatase activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0008331 high voltage-gated calcium channel activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0008474 palmitoyl-(protein) hydrolase activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0008559 ABC-type xenobiotic transporter activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0015386 potassium:proton antiporter activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0044548 S100 protein binding 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0098599 palmitoyl hydrolase activity 2/3948 14/18639 0.142857142857143 0.674446374294399 0.830037457015615 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/3948 26/18639 0.153846153846154 0.726326864624737 0.832023139939591 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/3948 26/18639 0.153846153846154 0.726326864624737 0.832023139939591 1 GO:0008157 protein phosphatase 1 binding 4/3948 26/18639 0.153846153846154 0.726326864624737 0.832023139939591 1 GO:0008378 galactosyltransferase activity 5/3948 32/18639 0.15625 0.737675721884498 0.838184194262757 1 GO:0015106 bicarbonate transmembrane transporter activity 5/3948 32/18639 0.15625 0.737675721884498 0.838184194262757 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/3948 32/18639 0.15625 0.737675721884498 0.838184194262757 1 GO:0042910 xenobiotic transmembrane transporter activity 5/3948 32/18639 0.15625 0.737675721884498 0.838184194262757 1 GO:0047498 calcium-dependent phospholipase A2 activity 5/3948 32/18639 0.15625 0.737675721884498 0.838184194262757 1 GO:0098631 cell adhesion mediator activity 13/3948 76/18639 0.171052631578947 0.807560790273556 0.844670653039427 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/3948 60/18639 0.166666666666667 0.786854103343465 0.845614372139308 1 GO:0019955 cytokine binding 26/3948 144/18639 0.180555555555556 0.852425278622087 0.847444264485018 1 GO:0140299 molecular sensor activity 12/3948 71/18639 0.169014084507042 0.797936555503232 0.849151005514513 1 GO:0098632 cell-cell adhesion mediator activity 9/3948 55/18639 0.163636363636364 0.772547665100857 0.852084710863532 1 GO:0015125 bile acid transmembrane transporter activity 3/3948 21/18639 0.142857142857143 0.674446374294399 0.852968177788405 1 GO:0015174 basic amino acid transmembrane transporter activity 3/3948 21/18639 0.142857142857143 0.674446374294399 0.852968177788405 1 GO:0036122 BMP binding 3/3948 21/18639 0.142857142857143 0.674446374294399 0.852968177788405 1 GO:0099106 ion channel regulator activity 29/3948 160/18639 0.18125 0.855703837386018 0.853112405066652 1 GO:0016405 CoA-ligase activity 4/3948 27/18639 0.148148148148148 0.699425869638636 0.853965928989568 1 GO:0001216 DNA-binding transcription activator activity 95/3948 491/18639 0.193482688391039 0.913455883718483 0.856564297057303 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/3948 15/18639 0.133333333333333 0.629483282674772 0.858497891523878 1 GO:0031386 protein tag activity 2/3948 15/18639 0.133333333333333 0.629483282674772 0.858497891523878 1 GO:0141047 molecular tag activity 2/3948 15/18639 0.133333333333333 0.629483282674772 0.858497891523878 1 GO:0046625 sphingolipid binding 4/3948 28/18639 0.142857142857143 0.674446374294399 0.873420524600368 1 GO:0051119 sugar transmembrane transporter activity 4/3948 28/18639 0.142857142857143 0.674446374294399 0.873420524600368 1 GO:0005010 insulin-like growth factor receptor activity 8/3948 51/18639 0.156862745098039 0.740568567852673 0.874110138854414 1 GO:0005021 vascular endothelial growth factor receptor activity 8/3948 51/18639 0.156862745098039 0.740568567852673 0.874110138854414 1 GO:0016597 amino acid binding 8/3948 51/18639 0.156862745098039 0.740568567852673 0.874110138854414 1 GO:0008970 phospholipase A1 activity 3/3948 22/18639 0.136363636363636 0.64378972091738 0.874646531887137 1 GO:0005319 lipid transporter activity 32/3948 178/18639 0.179775280898876 0.84874150473003 0.874857574751463 1 GO:0015035 protein-disulfide reductase activity 5/3948 34/18639 0.147058823529412 0.694283032361881 0.875272938950857 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 5/3948 34/18639 0.147058823529412 0.694283032361881 0.875272938950857 1 GO:0051427 hormone receptor binding 5/3948 34/18639 0.147058823529412 0.694283032361881 0.875272938950857 1 GO:0030246 carbohydrate binding 52/3948 280/18639 0.185714285714286 0.876780286582718 0.876108412060902 1 GO:0015036 disulfide oxidoreductase activity 6/3948 40/18639 0.15 0.708168693009119 0.878663037824142 1 GO:0005149 interleukin-1 receptor binding 2/3948 16/18639 0.125 0.590140577507599 0.882530375974374 1 GO:0019841 retinol binding 2/3948 16/18639 0.125 0.590140577507599 0.882530375974374 1 GO:0022841 potassium ion leak channel activity 2/3948 16/18639 0.125 0.590140577507599 0.882530375974374 1 GO:0004623 phospholipase A2 activity 5/3948 35/18639 0.142857142857143 0.674446374294399 0.89093439761584 1 GO:0016229 steroid dehydrogenase activity 5/3948 35/18639 0.142857142857143 0.674446374294399 0.89093439761584 1 GO:0043015 gamma-tubulin binding 5/3948 35/18639 0.142857142857143 0.674446374294399 0.89093439761584 1 GO:0048306 calcium-dependent protein binding 13/3948 80/18639 0.1625 0.767182750759878 0.891539879796117 1 GO:0072341 modified amino acid binding 15/3948 91/18639 0.164835164835165 0.778207354955075 0.893133548692378 1 GO:0043274 phospholipase binding 3/3948 23/18639 0.130434782608696 0.61579886348619 0.893439639931949 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/3948 23/18639 0.130434782608696 0.61579886348619 0.893439639931949 1 GO:0099186 structural constituent of postsynapse 3/3948 23/18639 0.130434782608696 0.61579886348619 0.893439639931949 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/3948 23/18639 0.130434782608696 0.61579886348619 0.893439639931949 1 GO:0017046 peptide hormone binding 8/3948 53/18639 0.150943396226415 0.712622584160119 0.899457740680597 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/3948 17/18639 0.117647058823529 0.555426425889505 0.902733337861928 1 GO:0008569 minus-end-directed microtubule motor activity 2/3948 17/18639 0.117647058823529 0.555426425889505 0.902733337861928 1 GO:0016805 dipeptidase activity 2/3948 17/18639 0.117647058823529 0.555426425889505 0.902733337861928 1 GO:0030548 acetylcholine receptor regulator activity 2/3948 17/18639 0.117647058823529 0.555426425889505 0.902733337861928 1 GO:0045125 bioactive lipid receptor activity 2/3948 17/18639 0.117647058823529 0.555426425889505 0.902733337861928 1 GO:0045236 CXCR chemokine receptor binding 2/3948 17/18639 0.117647058823529 0.555426425889505 0.902733337861928 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/3948 59/18639 0.152542372881356 0.720171552212663 0.903215445189441 1 GO:0070566 adenylyltransferase activity 4/3948 30/18639 0.133333333333333 0.629483282674772 0.905686076629969 1 GO:0098918 structural constituent of synapse 4/3948 30/18639 0.133333333333333 0.629483282674772 0.905686076629969 1 GO:0022804 active transmembrane transporter activity 86/3948 457/18639 0.188183807439825 0.888439206400936 0.906245782997692 1 GO:0038024 cargo receptor activity 10/3948 65/18639 0.153846153846154 0.726326864624737 0.907082756554251 1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0005337 nucleoside transmembrane transporter activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0008519 ammonium channel activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0016783 sulfurtransferase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0019531 oxalate transmembrane transporter activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0031996 thioesterase binding 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0032052 bile acid binding 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0032395 MHC class II receptor activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0043208 glycosphingolipid binding 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0070739 protein-glutamic acid ligase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0070740 tubulin-glutamic acid ligase activity 1/3948 10/18639 0.1 0.472112462006079 0.907528985566625 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0004622 lysophospholipase activity 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0015149 hexose transmembrane transporter activity 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0030552 cAMP binding 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0048027 mRNA 5'-UTR binding 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0055056 D-glucose transmembrane transporter activity 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/3948 24/18639 0.125 0.590140577507599 0.909660747291939 1 GO:0061135 endopeptidase regulator activity 32/3948 184/18639 0.173913043478261 0.82106515131492 0.914900067389601 1 GO:0004222 metalloendopeptidase activity 18/3948 110/18639 0.163636363636364 0.772547665100857 0.916167972205765 1 GO:0030551 cyclic nucleotide binding 5/3948 37/18639 0.135135135135135 0.637989813521728 0.917222804623722 1 GO:0005245 voltage-gated calcium channel activity 6/3948 43/18639 0.13953488372093 0.658761574892203 0.91732159096963 1 GO:0005164 tumor necrosis factor receptor binding 4/3948 31/18639 0.129032258064516 0.609177370330425 0.918902632398073 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/3948 31/18639 0.129032258064516 0.609177370330425 0.918902632398073 1 GO:0015172 acidic amino acid transmembrane transporter activity 2/3948 18/18639 0.111111111111111 0.524569402228977 0.919650416341849 1 GO:0099602 neurotransmitter receptor regulator activity 2/3948 18/18639 0.111111111111111 0.524569402228977 0.919650416341849 1 GO:0015271 outward rectifier potassium channel activity 3/3948 25/18639 0.12 0.566534954407295 0.923606312889832 1 GO:0015645 fatty acid ligase activity 3/3948 25/18639 0.12 0.566534954407295 0.923606312889832 1 GO:0047617 fatty acyl-CoA hydrolase activity 3/3948 25/18639 0.12 0.566534954407295 0.923606312889832 1 GO:0120515 fatty acid-CoA ligase activity 3/3948 25/18639 0.12 0.566534954407295 0.923606312889832 1 GO:0008514 organic anion transmembrane transporter activity 48/3948 269/18639 0.178438661710037 0.842431158969955 0.925179860083473 1 GO:0001851 complement component C3b binding 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0003953 NAD+ nucleosidase activity 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0010854 adenylate cyclase regulator activity 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0016594 glycine binding 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0042608 T cell receptor binding 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0050786 RAGE receptor binding 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/3948 11/18639 0.0909090909090909 0.429193147278254 0.927126149396297 1 GO:0005501 retinoid binding 5/3948 38/18639 0.131578947368421 0.621200607902736 0.928138007638911 1 GO:0019840 isoprenoid binding 5/3948 38/18639 0.131578947368421 0.621200607902736 0.928138007638911 1 GO:0170055 lipid transmembrane transporter activity 8/3948 56/18639 0.142857142857143 0.674446374294399 0.929322985590939 1 GO:0005520 insulin-like growth factor binding 2/3948 19/18639 0.105263157894737 0.496960486322188 0.933766819645113 1 GO:0016918 retinal binding 2/3948 19/18639 0.105263157894737 0.496960486322188 0.933766819645113 1 GO:0022840 leak channel activity 2/3948 19/18639 0.105263157894737 0.496960486322188 0.933766819645113 1 GO:0022842 narrow pore channel activity 2/3948 19/18639 0.105263157894737 0.496960486322188 0.933766819645113 1 GO:0042834 peptidoglycan binding 2/3948 19/18639 0.105263157894737 0.496960486322188 0.933766819645113 1 GO:0050145 nucleoside monophosphate kinase activity 2/3948 19/18639 0.105263157894737 0.496960486322188 0.933766819645113 1 GO:0004435 phosphatidylinositol phospholipase C activity 3/3948 26/18639 0.115384615384615 0.544745148468553 0.935551944144211 1 GO:0005227 calcium-activated cation channel activity 3/3948 26/18639 0.115384615384615 0.544745148468553 0.935551944144211 1 GO:0015145 monosaccharide transmembrane transporter activity 3/3948 26/18639 0.115384615384615 0.544745148468553 0.935551944144211 1 GO:0016289 acyl-CoA hydrolase activity 3/3948 26/18639 0.115384615384615 0.544745148468553 0.935551944144211 1 GO:0030247 polysaccharide binding 3/3948 26/18639 0.115384615384615 0.544745148468553 0.935551944144211 1 GO:0140303 intramembrane lipid transporter activity 6/3948 45/18639 0.133333333333333 0.629483282674772 0.936681939849856 1 GO:0005030 neurotrophin receptor activity 7/3948 51/18639 0.137254901960784 0.647997496871089 0.936683878189684 1 GO:0005436 sodium:phosphate symporter activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0008504 monoamine transmembrane transporter activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0010853 cyclase activator activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0015269 calcium-activated potassium channel activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0042301 phosphate ion binding 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0097677 STAT family protein binding 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/3948 12/18639 0.0833333333333333 0.393427051671733 0.94257096162431 1 GO:0030627 pre-mRNA 5'-splice site binding 2/3948 20/18639 0.1 0.472112462006079 0.94550968257437 1 GO:0004364 glutathione transferase activity 3/3948 27/18639 0.111111111111111 0.524569402228977 0.945750196038542 1 GO:0023026 MHC class II protein complex binding 3/3948 27/18639 0.111111111111111 0.524569402228977 0.945750196038542 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/3948 27/18639 0.111111111111111 0.524569402228977 0.945750196038542 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 10/3948 70/18639 0.142857142857143 0.674446374294399 0.946544837460917 1 GO:0015020 glucuronosyltransferase activity 4/3948 34/18639 0.117647058823529 0.555426425889505 0.949152614017289 1 GO:0015459 potassium channel regulator activity 8/3948 59/18639 0.135593220338983 0.6401524908557 0.951150408041254 1 GO:0005544 calcium-dependent phospholipid binding 7/3948 53/18639 0.132075471698113 0.623544761140104 0.951185864293704 1 GO:0042287 MHC protein binding 5/3948 41/18639 0.121951219512195 0.575746904885462 0.953583274362689 1 GO:0045499 chemorepellent activity 3/3948 28/18639 0.107142857142857 0.505834780720799 0.954429756611123 1 GO:0004465 lipoprotein lipase activity 1/3948 13/18639 0.0769230769230769 0.363163432312369 0.954743068968876 1 GO:0005542 folic acid binding 1/3948 13/18639 0.0769230769230769 0.363163432312369 0.954743068968876 1 GO:0031994 insulin-like growth factor I binding 1/3948 13/18639 0.0769230769230769 0.363163432312369 0.954743068968876 1 GO:0061459 L-arginine transmembrane transporter activity 1/3948 13/18639 0.0769230769230769 0.363163432312369 0.954743068968876 1 GO:0140333 glycerophospholipid flippase activity 1/3948 13/18639 0.0769230769230769 0.363163432312369 0.954743068968876 1 GO:0070851 growth factor receptor binding 22/3948 139/18639 0.158273381294964 0.747228357131924 0.95501398810609 1 GO:0001846 opsonin binding 2/3948 21/18639 0.0952380952380952 0.449630916196266 0.955250893604471 1 GO:0005248 voltage-gated sodium channel activity 2/3948 21/18639 0.0952380952380952 0.449630916196266 0.955250893604471 1 GO:0008373 sialyltransferase activity 2/3948 21/18639 0.0952380952380952 0.449630916196266 0.955250893604471 1 GO:0051428 peptide hormone receptor binding 2/3948 21/18639 0.0952380952380952 0.449630916196266 0.955250893604471 1 GO:0042056 chemoattractant activity 5/3948 42/18639 0.119047619047619 0.562038645245332 0.960036675966767 1 GO:0004181 metallocarboxypeptidase activity 3/3948 29/18639 0.103448275862069 0.488392202075254 0.961795632437266 1 GO:0004629 phospholipase C activity 3/3948 29/18639 0.103448275862069 0.488392202075254 0.961795632437266 1 GO:0005416 amino acid:monoatomic cation symporter activity 3/3948 29/18639 0.103448275862069 0.488392202075254 0.961795632437266 1 GO:0046906 tetrapyrrole binding 24/3948 152/18639 0.157894736842105 0.745440729483283 0.962293520304157 1 GO:0015171 amino acid transmembrane transporter activity 15/3948 102/18639 0.147058823529412 0.694283032361881 0.962692979921463 1 GO:0046982 protein heterodimerization activity 65/3948 369/18639 0.176151761517615 0.83163441816789 0.962898100917146 1 GO:0033293 monocarboxylic acid binding 11/3948 79/18639 0.139240506329114 0.65737178254011 0.962905715403018 1 GO:0140784 metal ion sensor activity 2/3948 22/18639 0.0909090909090909 0.429193147278254 0.963311329776205 1 GO:0005004 GPI-linked ephrin receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0005008 hepatocyte growth factor receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0005009 insulin receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0005011 macrophage colony-stimulating factor receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0005020 stem cell factor receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0008288 boss receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0036332 placental growth factor receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0038062 protein tyrosine kinase collagen receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0060175 brain-derived neurotrophic factor receptor activity 6/3948 49/18639 0.122448979591837 0.578096892252342 0.963735683276596 1 GO:0005313 L-glutamate transmembrane transporter activity 1/3948 14/18639 0.0714285714285714 0.337223187147199 0.964335808349896 1 GO:0019763 immunoglobulin receptor activity 1/3948 14/18639 0.0714285714285714 0.337223187147199 0.964335808349896 1 GO:0034236 protein kinase A catalytic subunit binding 1/3948 14/18639 0.0714285714285714 0.337223187147199 0.964335808349896 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/3948 14/18639 0.0714285714285714 0.337223187147199 0.964335808349896 1 GO:0020037 heme binding 22/3948 142/18639 0.154929577464789 0.731441842544629 0.965464681122806 1 GO:0022839 monoatomic ion-gated channel activity 3/3948 30/18639 0.1 0.472112462006079 0.968030027526965 1 GO:0048019 receptor antagonist activity 3/3948 30/18639 0.1 0.472112462006079 0.968030027526965 1 GO:0005006 epidermal growth factor receptor activity 6/3948 50/18639 0.12 0.566534954407295 0.968595732032691 1 GO:0005007 fibroblast growth factor receptor activity 6/3948 50/18639 0.12 0.566534954407295 0.968595732032691 1 GO:0005017 platelet-derived growth factor receptor activity 6/3948 50/18639 0.12 0.566534954407295 0.968595732032691 1 GO:0005019 platelet-derived growth factor beta-receptor activity 6/3948 50/18639 0.12 0.566534954407295 0.968595732032691 1 GO:0022829 wide pore channel activity 4/3948 37/18639 0.108108108108108 0.510391850817383 0.968704702820618 1 GO:0023023 MHC protein complex binding 4/3948 37/18639 0.108108108108108 0.510391850817383 0.968704702820618 1 GO:0042626 ATPase-coupled transmembrane transporter activity 14/3948 98/18639 0.142857142857143 0.674446374294399 0.968889673768957 1 GO:0004602 glutathione peroxidase activity 2/3948 23/18639 0.0869565217391304 0.41053257565746 0.969965776428038 1 GO:0005283 amino acid:sodium symporter activity 2/3948 23/18639 0.0869565217391304 0.41053257565746 0.969965776428038 1 GO:0016493 C-C chemokine receptor activity 2/3948 23/18639 0.0869565217391304 0.41053257565746 0.969965776428038 1 GO:0016917 GABA receptor activity 2/3948 23/18639 0.0869565217391304 0.41053257565746 0.969965776428038 1 GO:0004601 peroxidase activity 7/3948 57/18639 0.12280701754386 0.579787234042553 0.971596807656789 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0015116 sulfate transmembrane transporter activity 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0017081 chloride channel regulator activity 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0030553 cGMP binding 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0033130 acetylcholine receptor binding 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0047372 monoacylglycerol lipase activity 1/3948 15/18639 0.0666666666666667 0.314741641337386 0.971895659551754 1 GO:0005126 cytokine receptor binding 46/3948 275/18639 0.167272727272727 0.789715390991987 0.973597364685809 1 GO:0008083 growth factor activity 25/3948 162/18639 0.154320987654321 0.728568614206912 0.9745042810875 1 GO:0019957 C-C chemokine binding 2/3948 24/18639 0.0833333333333333 0.393427051671733 0.975448051804048 1 GO:0005200 structural constituent of cytoskeleton 16/3948 112/18639 0.142857142857143 0.674446374294399 0.976113674544951 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/3948 52/18639 0.115384615384615 0.544745148468553 0.976567619518988 1 GO:0004867 serine-type endopeptidase inhibitor activity 13/3948 95/18639 0.136842105263158 0.646048632218845 0.977260044797745 1 GO:0008296 3'-5'-DNA exonuclease activity 1/3948 16/18639 0.0625 0.295070288753799 0.977853345123579 1 GO:0055102 lipase inhibitor activity 1/3948 16/18639 0.0625 0.295070288753799 0.977853345123579 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/3948 16/18639 0.0625 0.295070288753799 0.977853345123579 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/3948 16/18639 0.0625 0.295070288753799 0.977853345123579 1 GO:0140328 floppase activity 1/3948 16/18639 0.0625 0.295070288753799 0.977853345123579 1 GO:0005003 ephrin receptor activity 6/3948 53/18639 0.113207547169811 0.534466938120089 0.979807843590301 1 GO:0005005 transmembrane-ephrin receptor activity 6/3948 53/18639 0.113207547169811 0.534466938120089 0.979807843590301 1 GO:0008146 sulfotransferase activity 6/3948 53/18639 0.113207547169811 0.534466938120089 0.979807843590301 1 GO:0038064 collagen receptor activity 6/3948 53/18639 0.113207547169811 0.534466938120089 0.979807843590301 1 GO:0005251 delayed rectifier potassium channel activity 2/3948 25/18639 0.08 0.377689969604863 0.979956029100936 1 GO:0015103 inorganic anion transmembrane transporter activity 25/3948 165/18639 0.151515151515152 0.715321912130423 0.980520188181836 1 GO:0015144 carbohydrate transmembrane transporter activity 4/3948 40/18639 0.1 0.472112462006079 0.981045510499135 1 GO:0030296 protein tyrosine kinase activator activity 3/3948 33/18639 0.0909090909090909 0.429193147278254 0.981454110062885 1 GO:0005504 fatty acid binding 5/3948 47/18639 0.106382978723404 0.502247300006467 0.981590942942582 1 GO:0009881 photoreceptor activity 1/3948 17/18639 0.0588235294117647 0.277713212944752 0.982548345577433 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/3948 17/18639 0.0588235294117647 0.277713212944752 0.982548345577433 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/3948 17/18639 0.0588235294117647 0.277713212944752 0.982548345577433 1 GO:0036041 long-chain fatty acid binding 1/3948 17/18639 0.0588235294117647 0.277713212944752 0.982548345577433 1 GO:0038191 neuropilin binding 1/3948 17/18639 0.0588235294117647 0.277713212944752 0.982548345577433 1 GO:0015108 chloride transmembrane transporter activity 17/3948 121/18639 0.140495867768595 0.663298500339119 0.983031080937468 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/3948 26/18639 0.0769230769230769 0.363163432312369 0.983656369513996 1 GO:0004950 chemokine receptor activity 2/3948 26/18639 0.0769230769230769 0.363163432312369 0.983656369513996 1 GO:0019865 immunoglobulin binding 2/3948 26/18639 0.0769230769230769 0.363163432312369 0.983656369513996 1 GO:0043548 phosphatidylinositol 3-kinase binding 2/3948 26/18639 0.0769230769230769 0.363163432312369 0.983656369513996 1 GO:0038187 pattern recognition receptor activity 5/3948 48/18639 0.104166666666667 0.491783814589666 0.984311156631781 1 GO:0004970 glutamate-gated receptor activity 1/3948 18/18639 0.0555555555555556 0.262284701114488 0.986248223767761 1 GO:0015280 ligand-gated sodium channel activity 1/3948 18/18639 0.0555555555555556 0.262284701114488 0.986248223767761 1 GO:0017075 syntaxin-1 binding 1/3948 18/18639 0.0555555555555556 0.262284701114488 0.986248223767761 1 GO:0022851 GABA-gated chloride ion channel activity 1/3948 18/18639 0.0555555555555556 0.262284701114488 0.986248223767761 1 GO:0032393 MHC class I receptor activity 1/3948 18/18639 0.0555555555555556 0.262284701114488 0.986248223767761 1 GO:0034185 apolipoprotein binding 1/3948 18/18639 0.0555555555555556 0.262284701114488 0.986248223767761 1 GO:0005104 fibroblast growth factor receptor binding 2/3948 27/18639 0.0740740740740741 0.349712934819318 0.986688863392033 1 GO:0008395 steroid hydroxylase activity 2/3948 27/18639 0.0740740740740741 0.349712934819318 0.986688863392033 1 GO:0005343 organic acid:sodium symporter activity 3/3948 35/18639 0.0857142857142857 0.404667824576639 0.987197131857452 1 GO:0031406 carboxylic acid binding 28/3948 187/18639 0.149732620320856 0.706906360223006 0.987906387505677 1 GO:0016782 transferase activity, transferring sulphur-containing groups 8/3948 70/18639 0.114285714285714 0.539557099435519 0.988863181552179 1 GO:0015291 secondary active transmembrane transporter activity 46/3948 287/18639 0.160278745644599 0.756695932135179 0.988937059857241 1 GO:0004890 GABA-A receptor activity 1/3948 19/18639 0.0526315789473684 0.248480243161094 0.98916385733013 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/3948 19/18639 0.0526315789473684 0.248480243161094 0.98916385733013 1 GO:0141147 intracellularly calcium-gated channel activity 1/3948 19/18639 0.0526315789473684 0.248480243161094 0.98916385733013 1 GO:0005254 chloride channel activity 10/3948 83/18639 0.120481927710843 0.568810195188047 0.989369071309065 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/3948 36/18639 0.0833333333333333 0.393427051671733 0.989384226371335 1 GO:0043177 organic acid binding 28/3948 189/18639 0.148148148148148 0.699425869638636 0.989941077296991 1 GO:0030547 signaling receptor inhibitor activity 4/3948 44/18639 0.0909090909090909 0.429193147278254 0.990494047992037 1 GO:0003785 actin monomer binding 2/3948 29/18639 0.0689655172413793 0.325594801383503 0.991198088752347 1 GO:0051861 glycolipid binding 2/3948 29/18639 0.0689655172413793 0.325594801383503 0.991198088752347 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/3948 20/18639 0.05 0.23605623100304 0.99146144547517 1 GO:0005326 neurotransmitter transmembrane transporter activity 1/3948 20/18639 0.05 0.23605623100304 0.99146144547517 1 GO:0010851 cyclase regulator activity 1/3948 20/18639 0.05 0.23605623100304 0.99146144547517 1 GO:0030414 peptidase inhibitor activity 24/3948 169/18639 0.142011834319527 0.670455567345911 0.992281110068102 1 GO:0016209 antioxidant activity 10/3948 86/18639 0.116279069767442 0.548967979076836 0.992901706575472 1 GO:0061891 calcium ion sensor activity 1/3948 21/18639 0.0476190476190476 0.224815458098133 0.993271973068705 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/3948 46/18639 0.0869565217391304 0.41053257565746 0.993322693595947 1 GO:0046943 carboxylic acid transmembrane transporter activity 27/3948 188/18639 0.143617021276596 0.678033855008731 0.993553176604596 1 GO:0016298 lipase activity 17/3948 130/18639 0.130769230769231 0.617377834931026 0.993756305685078 1 GO:0004497 monooxygenase activity 13/3948 106/18639 0.122641509433962 0.579005849630097 0.993966839891097 1 GO:0005342 organic acid transmembrane transporter activity 27/3948 189/18639 0.142857142857143 0.674446374294399 0.994155193155863 1 GO:0140359 ABC-type transporter activity 4/3948 47/18639 0.0851063829787234 0.401797840005174 0.99441401923812 1 GO:0008509 monoatomic anion transmembrane transporter activity 20/3948 149/18639 0.134228187919463 0.633708002692724 0.994533681843187 1 GO:0004866 endopeptidase inhibitor activity 22/3948 161/18639 0.136645962732919 0.645122618890294 0.994679607423791 1 GO:0033691 sialic acid binding 1/3948 22/18639 0.0454545454545455 0.214596573639127 0.994698670368348 1 GO:0140662 ATP-dependent protein folding chaperone 3/3948 40/18639 0.075 0.354084346504559 0.99504256814725 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/3948 23/18639 0.0434782608695652 0.20526628782873 0.99582289282018 1 GO:0031681 G-protein beta-subunit binding 1/3948 23/18639 0.0434782608695652 0.20526628782873 0.99582289282018 1 GO:0004620 phospholipase activity 13/3948 109/18639 0.119266055045872 0.56306990881459 0.995891893556668 1 GO:0001530 lipopolysaccharide binding 3/3948 41/18639 0.0731707317073171 0.345448142931277 0.995913212930538 1 GO:0005253 monoatomic anion channel activity 12/3948 103/18639 0.116504854368932 0.550033936317762 0.996042058027034 1 GO:0015294 solute:monoatomic cation symporter activity 14/3948 116/18639 0.120689655172414 0.56979090242113 0.99627915264804 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/3948 24/18639 0.0416666666666667 0.196713525835866 0.996708755473056 1 GO:0030215 semaphorin receptor binding 1/3948 24/18639 0.0416666666666667 0.196713525835866 0.996708755473056 1 GO:0048020 CCR chemokine receptor binding 4/3948 50/18639 0.08 0.377689969604863 0.996752045105079 1 GO:0042379 chemokine receptor binding 7/3948 72/18639 0.0972222222222222 0.458998226950355 0.996969316179456 1 GO:0001848 complement binding 1/3948 25/18639 0.04 0.188844984802432 0.997406785738561 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/3948 25/18639 0.04 0.188844984802432 0.997406785738561 1 GO:0008081 phosphoric diester hydrolase activity 9/3948 87/18639 0.103448275862069 0.488392202075254 0.997569247517992 1 GO:0016500 protein-hormone receptor activity 6/3948 67/18639 0.0895522388059701 0.422787279408429 0.997819106048325 1 GO:0008066 glutamate receptor activity 1/3948 26/18639 0.0384615384615385 0.181581716156184 0.997956802387543 1 GO:0008236 serine-type peptidase activity 26/3948 194/18639 0.134020618556701 0.632728041863817 0.998078987487216 1 GO:0008009 chemokine activity 3/3948 45/18639 0.0666666666666667 0.314741641337386 0.998130726657015 1 GO:0017171 serine hydrolase activity 26/3948 198/18639 0.131313131313131 0.6199456571797 0.998756727215159 1 GO:0004896 cytokine receptor activity 9/3948 96/18639 0.09375 0.442605433130699 0.999387315559511 1 GO:0005272 sodium channel activity 3/3948 51/18639 0.0588235294117647 0.277713212944752 0.999436104035146 1 GO:0015293 symporter activity 16/3948 146/18639 0.10958904109589 0.517383520006662 0.999620432551764 1 GO:0019825 oxygen binding 1/3948 34/18639 0.0294117647058824 0.138856606472376 0.999696708697143 1 GO:0042605 peptide antigen binding 2/3948 45/18639 0.0444444444444444 0.209827760891591 0.99971137765604 1 GO:0015370 solute:sodium symporter activity 6/3948 79/18639 0.0759493670886076 0.35856642684006 0.999725257930429 1 GO:0004252 serine-type endopeptidase activity 20/3948 176/18639 0.113636363636364 0.536491434097817 0.99978851222016 1 GO:0003730 mRNA 3'-UTR binding 34/3948 262/18639 0.129770992366412 0.61266502703079 0.999794050636499 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/3948 36/18639 0.0277777777777778 0.131142350557244 0.99981177188385 1 GO:0099095 ligand-gated monoatomic anion channel activity 2/3948 47/18639 0.0425531914893617 0.200898920002587 0.999813556814577 1 GO:0015079 potassium ion transmembrane transporter activity 17/3948 160/18639 0.10625 0.501619490881459 0.999864320851218 1 GO:0005249 voltage-gated potassium channel activity 7/3948 98/18639 0.0714285714285714 0.337223187147199 0.99996326246477 1 GO:0099094 ligand-gated monoatomic cation channel activity 12/3948 136/18639 0.0882352941176471 0.416569819417129 0.9999690262241 1 GO:0001664 G protein-coupled receptor binding 37/3948 297/18639 0.124579124579125 0.588153572196125 0.99996922885452 1 GO:0015081 sodium ion transmembrane transporter activity 16/3948 164/18639 0.0975609756097561 0.46059752390837 0.999970412226051 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/3948 56/18639 0.0357142857142857 0.1686115935736 0.999974383090011 1 GO:0022832 voltage-gated channel activity 17/3948 175/18639 0.0971428571428571 0.458623534520191 0.999984096862386 1 GO:0005261 monoatomic cation channel activity 43/3948 341/18639 0.126099706744868 0.595332430095642 0.999987204810861 1 GO:0140375 immune receptor activity 14/3948 156/18639 0.0897435897435897 0.423690671031097 0.999987710942097 1 GO:0022843 voltage-gated monoatomic cation channel activity 12/3948 143/18639 0.0839160839160839 0.396178289795311 0.99998993764862 1 GO:0005244 voltage-gated monoatomic ion channel activity 16/3948 173/18639 0.092485549132948 0.436635803011403 0.999992311748231 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/3948 73/18639 0.0410958904109589 0.194018820002498 0.999994187242782 1 GO:0005267 potassium channel activity 9/3948 124/18639 0.0725806451612903 0.342662270810864 0.999994293734802 1 GO:0046873 metal ion transmembrane transporter activity 60/3948 450/18639 0.133333333333333 0.629483282674772 0.999994620654312 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/3948 63/18639 0.0317460317460317 0.149876972065422 0.999994621330738 1 GO:0022835 transmitter-gated channel activity 2/3948 63/18639 0.0317460317460317 0.149876972065422 0.999994621330738 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/3948 53/18639 0.0188679245283019 0.0890778230200149 0.999996744056803 1 GO:0005125 cytokine activity 24/3948 234/18639 0.102564102564103 0.484217909749825 0.99999721273845 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/3948 69/18639 0.0289855072463768 0.13684419188582 0.999998601857582 1 GO:0030594 neurotransmitter receptor activity 4/3948 97/18639 0.0412371134020619 0.194685551342713 0.999999711573681 1 GO:0005216 monoatomic ion channel activity 55/3948 448/18639 0.122767857142857 0.579602352909249 0.999999742159213 1 GO:0022834 ligand-gated channel activity 15/3948 188/18639 0.0797872340425532 0.37668547500485 0.99999977096013 1 GO:0001653 peptide receptor activity 7/3948 128/18639 0.0546875 0.258186502659574 0.999999864769937 1 GO:0015276 ligand-gated monoatomic ion channel activity 14/3948 186/18639 0.0752688172043011 0.355353466026081 0.999999907836785 1 GO:0008528 G protein-coupled peptide receptor activity 6/3948 122/18639 0.0491803278688525 0.232186456724301 0.999999921811375 1 GO:0022836 gated channel activity 31/3948 318/18639 0.0974842767295598 0.460235418936744 0.999999985877881 1 GO:0005179 hormone activity 6/3948 132/18639 0.0454545454545455 0.214596573639127 0.999999989505757 1 GO:0003823 antigen binding 7/3948 174/18639 0.0402298850574713 0.189930300807043 0.999999999986491 1 GO:0030371 translation repressor activity 11/3948 329/18639 0.033434650455927 0.157849151430604 1 1 GO:0045182 translation regulator activity 13/3948 356/18639 0.0365168539325843 0.172400618148287 1 1