category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	50/1021	203/9376	2.26186053468299	JUN/COL1A1/COL6A2/HGF/COL6A1/FN1/SPP1/ARHGAP5/PIK3R1/ROCK1/COL1A2/ROCK2/IGF1/COL4A2/CCND1/MYL9/COL4A1/FLNA/PDGFC/TNXB/ITGAV/ITGA6/ACTN4/VAV1/ARHGAP35/BRAF/GSK3B/LAMC1/CCND2/EGFR/SOS1/PIK3R3/LAMB2/RAF1/LAMB1/COL6A3/PDGFRA/MYLK/LAMA2/FLT1/LAMA4/IGF1R/DOCK1/PPP1R12B/VCL/AKT2/ITGA5/LAMC3/ACTN1/PPP1R12C	6.3537330205247
NA	NA	hsa04518	Integrin signaling	38/1021	154/9376	2.26597300838241	COL1A1/COL6A2/HGF/COL6A1/FN1/SPP1/PIK3R1/COL1A2/IGF1/COL4A2/CCND1/COL4A1/FLNA/PDGFC/TNXB/ITGAV/ITGA6/ACTN4/FBN1/ARHGEF6/GSK3B/LAMC1/CCND2/EGFR/PIK3R3/LAMB2/LAMB1/COL6A3/PDGFRA/LAMA2/FLT1/LAMA4/IGF1R/VCL/AKT2/ITGA5/LAMC3/ACTN1	5.53729332520155
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1021	362/9376	1.77574796673178	COL1A1/CSH1/COL6A2/FOXO3/HGF/COL6A1/FN1/SPP1/PIK3R1/PRLR/FGFR1/IL2RA/GNG2/TLR4/COL1A2/IGF1/COL4A2/CCND1/IKBKB/CREB3L2/PKN2/JAK2/COL4A1/CSF1R/IL6R/CREB1/PDGFC/CSH2/NR4A1/TNXB/ITGAV/ITGA6/IL4R/ATF6B/SGK3/ATF4/GSK3B/LAMC1/CCND2/CDK6/EGFR/TSC2/EIF4EBP1/JAK3/MAGI1/CSF3R/SOS1/PIK3R3/TSC1/LAMB2/RAF1/LAMB1/COL6A3/PDGFRA/INSR/IFNAR2/LAMA2/FLT1/LAMA4/BCL2L1/IGF1R/PRKAA1/RXRA/PPP2R2A/CREB3L1/RPS6KB1/AKT2/ITGA5/AREG/LAMC3	5.26188602086244
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	49/1021	233/9376	1.93122117926967	TPM1/COL1A1/COL6A2/DCN/COL3A1/COL6A1/FN1/VIM/FBLN1/COL1A2/ATP1B1/COL4A2/MYL9/COL4A1/DSC2/VCAN/DAAM1/ITGAV/SYNE2/ITGA6/FMNL1/ATP1A1/FBN1/SPTBN1/PDLIM5/TTN/NID1/PLEC/COL5A1/TPM2/FHL1/SDC2/COL6A3/FBN2/SPTAN1/PDLIM7/BGN/DES/LAMA2/TNNT3/DTNA/MYH10/LMOD1/SYNE1/VCL/ITGA5/SUN1/AMPD3/DAG1	5.03166510178992
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	25/1021	93/9376	2.46858972333681	FN1/PIK3R1/COL4A2/CCND1/IKBKB/COL4A1/GADD45B/SKP2/ITGAV/ITGA6/POLK/LAMC1/CDK6/E2F3/PIK3R3/LAMB2/LAMB1/LAMA2/LAMA4/BCL2L1/RXRA/AKT2/TRAF5/LAMC3/BIRC7	4.97534345437388
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	43/1021	204/9376	1.93566476541645	COL1A1/ITPR2/HGF/DCN/FN1/PIK3R1/ROCK1/FGFR1/TLR4/COL1A2/ROCK2/IGF1/LUM/CCND1/STAT3/TNF/TIMP3/MMP2/GPC3/FLNA/CBL/ITGAV/VAV1/BRAF/PLCG2/EGFR/ARHGEF1/PRKACB/SOS1/PIK3R3/PTPN11/RAF1/WNT2/SDC2/MAPK14/TIAM1/IGF1R/FRS2/RPS6KB1/PPP1R12B/AKT2/ITGA5/PPP1R12C	4.72311606793181
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	61/1021	333/9376	1.68219933939816	RBPJ/COL1A1/COL6A2/ATM/ATP6V0A1/COL6A1/FN1/SPP1/PIK3R1/APC/EP300/ATP6V0B/COL1A2/MAML2/UBE3A/COL4A2/CCND1/IKBKB/CREB3L2/ATP6V0D1/TNF/COL4A1/CHD4/IRF3/CREB1/TNXB/ITGAV/NFX1/BCAP31/ITGA6/GSK3B/LAMC1/UBR4/DLG1/CCND2/CDK6/EGFR/TSC2/EIF4EBP1/PRKACB/MAGI1/TCF7L2/SOS1/PIK3R3/TSC1/LAMB2/RAF1/LAMB1/WNT2/COL6A3/IFNAR2/LAMA2/LAMA4/PPP2R2A/CREB3L1/RPS6KB1/NOTCH1/MAML3/AKT2/ITGA5/LAMC3	4.43100691702255
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1021	80/9376	2.52536728697356	FOXO3/HGF/PIK3R1/IGF1/JAK2/STAT3/NF1/IL6R/PDGFC/BRAF/GSK3B/PLCG2/EGFR/EIF4EBP1/SOS1/PIK3R3/RAF1/PDGFRA/BCL2L1/IGF1R/RPS6KB1/AKT2	4.78957133972859
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	30/1021	133/9376	2.07138806860442	FOXO3/ATM/PIK3R1/EP300/IGF1/CCND1/IKBKB/STAT3/DEPP1/GADD45B/SKP2/SGK3/BRAF/CCND2/EGFR/USP7/BCL6/SOD2/HOMER1/SOS1/PIK3R3/RAF1/FBXO25/PRKAG2/INSR/MAPK14/IGF1R/PRKAA1/AKT2/S1PR1	4.35002178268531
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	25/1021	103/9376	2.22892081815848	HSPB1/COL1A1/COL3A1/FN1/PIK3R1/SERPINB6/TLR4/COL1A2/COL4A2/CD14/TNF/COL4A1/PLCB2/ACTN4/LAMC1/PRKACB/PIK3R3/LAMB2/LAMB1/LAMA2/LAMA4/IL1R1/VCL/LAMC3/ACTN1	4.38386998872148
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	44/1021	227/9376	1.77999456350559	ITPR2/PIK3R1/AKAP13/ROCK1/IL10RA/GNG2/ROCK2/CCND1/IKBKB/CREB3L2/STAT3/TNF/PPP3CA/CCL5/IRF3/IL6R/CREB1/NFATC2/ITGAV/PLCB2/ATF6B/ATF4/GSK3B/CDK6/EGFR/TSC2/EIF4EBP1/ARHGEF1/PRKACB/SP1/E2F3/SOS1/NFATC3/PIK3R3/TSC1/RAF1/PDGFRA/MAPK14/CREB3L1/IL1R1/RPS6KB1/AKT2/TRAF5/PTK2B	4.15856000706315
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/1021	227/9376	1.77999456350559	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/MT-ATP8/JUN/MT-ND6/FOXO3/HGF/PIK3R1/COX4I1/EPHX1/IKBKB/SLC26A2/NDUFS8/NDUFB7/ABL2/BRAF/NDUFS7/EGFR/NDUFS2/SOD2/SOS1/MAP2K7/NDUFB10/PIK3R3/PTPN11/RAF1/ATP5MC1/SLC25A4/MAPK14/MAP3K14/NDUFV1/AKT2/COX4I2/AHR/GSTM4	4.15856000706315
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	22/1021	90/9376	2.24477092175427	FOXO3/PIK3R1/RB1CC1/IGF1/CREB3L2/CREB1/ATF6B/ATF4/TSC2/EIF4EBP1/PRKACB/SOD2/EHMT1/PIK3R3/TSC1/PRKAG2/INSR/IGF1R/PRKAA1/CREB3L1/RPS6KB1/AKT2	4.14783652594006
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	19/1021	73/9376	2.39013591295131	FOXO3/HGF/PIK3R1/CCND1/STAT3/EML4/GADD45B/POLK/BRAF/PLCG2/CDK6/EGFR/E2F3/JAK3/SOS1/PIK3R3/RAF1/RXRA/AKT2	4.16804563022144
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	17/1021	63/9376	2.47799387466381	ASH1L/KMT2C/KMT2A/SETD2/KMT2E/NSD3/NSD1/HADHA/PRDM2/KMT5B/PHYKPL/KMT2B/SETDB2/EHMT1/DHTKD1/KMT2D/EZH1	4.11455990358347
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	33/1021	163/9376	1.85916610083943	DDX3X/JUN/PIK3R1/EP300/TLR4/MAVS/IKBKB/CREB3L2/JAK2/STAT3/TNF/IRF3/CREB1/NFATC2/STAT6/ATF6B/ATF4/BRAF/EGR2/E2F3/JAK3/SOS1/MAP2K7/EGR3/NFATC3/PIK3R3/RAF1/IRAK1/MAPK14/DDB1/CREB3L1/AKT2/PTK2B	3.8680820872135
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	39/1021	205/9376	1.74703901005709	RBPJ/DDX3X/JUN/REL/IL6ST/PIK3R1/EP300/UBE3A/CCND1/CREB3L2/STAT3/ATP6V0D1/CHD4/IRF3/LTBR/CREB1/HDAC9/SKP2/ACTN4/ATF6B/ATF4/UBR4/DLG1/CCND2/CDK6/EGR2/USP7/PRKACB/JAK3/HDAC7/EGR3/PIK3R3/RASA2/HDAC8/DDB1/CREB3L1/TRAF5/MAPKAPK2/ACTN1	3.78039471206961
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	39/1021	205/9376	1.74703901005709	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/CD36/MT-ND4L/MT-ATP8/COL1A1/MT-ND6/COL3A1/PIK3R1/COL1A2/COX4I1/MMP2/NCF4/NDUFS8/PLCB2/NDUFB7/GSK3B/NDUFS7/NDUFS2/SP1/NDUFB10/PPARA/PIK3R3/PDHB/ATP5MC1/INSR/SLC25A4/MAPK14/NDUFV1/AKT2/COX4I2	3.78039471206961
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/1021	106/9376	2.07920462735387	PIK3R1/FGFR1/EP300/IGF1/CCND1/IKBKB/CREB3L2/GSTP1/CREB1/PDGFC/ATF4/BRAF/GSK3B/EGFR/E2F3/TCF7L2/SOS1/PIK3R3/SLC46A1/RAF1/PDGFRA/IGF1R/CREB3L1/AKT2	3.90608910849185
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	43/1021	235/9376	1.68032175380832	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/ARID1A/ARID1B/FGFR1/COX4I1/CREB3L2/NDUFS8/SMARCA4/CREB1/NDUFB7/NDUFS7/TSC2/NDUFS2/PRKACB/SMARCC2/SOS1/NDUFB10/TSC1/PRKAG2/ATP5MC1/COA1/MAPK14/NDUFV1/PRKAA1/CREB3L1/FRS2/RPS6KB1/PNPLA2/COX4I2/NDUFAF8/KDM3B	3.6921277278217
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	21/1021	89/9376	2.16681156389968	CD36/COL1A1/COL6A2/COL6A1/FN1/SPP1/COL1A2/COL4A2/COL4A1/TNXB/ITGAV/ITGA6/LAMC1/LAMB2/LAMB1/COL6A3/LAMA2/LAMA4/ITGA5/LAMC3/DAG1	3.86619083790236
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	48/1021	275/9376	1.60287774908735	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/MT-ATP8/ITPR2/MT-ND6/PIK3R1/C7/COX4I1/CREB3L2/TNF/PPP3CA/CCL5/NCF4/NDUFS8/RYR1/CSNK2A1/CREB1/ATF6B/PSMD7/NDUFB7/ATF4/GSK3B/LAMC1/NDUFS7/NDUFS2/PRKACB/PSMD1/GRIN2C/PSMD13/NDUFB10/PIK3R3/KLC1/ATP5MC1/SLC25A4/MAPK14/NDUFV1/CREB3L1/NOTCH1/COX4I2	3.54712364383229
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	42/1021	232/9376	1.662467492992	WASF2/FN1/PIK3R1/ROCK1/FGFR1/NCKAP1L/APC/C7/IQGAP2/ROCK2/MYL9/PDGFC/ITGAV/ITGA6/PIKFYVE/ACTN4/ARHGEF6/VAV1/ARHGAP35/BRAF/ABI2/EGFR/ARHGEF1/SOS1/WASL/PIK3R3/RAF1/PDGFRA/MYLK/SSH1/TIAM1/MYH10/DOCK1/PPP1R12B/VCL/AKT2/ENAH/ITGA5/BAIAP2/ARHGEF7/ACTN1/PPP1R12C	3.57162404735771
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	51/1021	300/9376	1.5611361410382	HSPB1/MKNK1/JUN/HGF/DUSP6/FGFR1/MEF2C/TAOK1/IGF1/MAP3K8/MAP3K2/IKBKB/CD14/TNF/PPP3CA/RASA1/CSF1R/NF1/GADD45B/FLNA/PDGFC/NR4A1/MAP3K11/ATF4/BRAF/EGFR/PRKACB/SOS1/MAP2K7/PLA2G4C/PPM1A/NFATC3/RASA2/RAF1/IRAK1/MAP3K4/MAP3K3/STK3/PDGFRA/INSR/RASGRP3/MAPK14/MAPK8IP3/FLT1/MAP3K14/IGF1R/IL1R1/CACNB4/AKT2/AREG/MAPKAPK2	3.45308212265439
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	31/1021	158/9376	1.80175801832406	PIK3R1/CLIP1/IGF1/IKBKB/TNF/RICTOR/LPIN2/SKP2/FNIP1/BRAF/GSK3B/TSC2/EIF4EBP1/SOS1/PIK3R3/MAPKAP1/TSC1/RAF1/WNT2/INSR/STRADA/NPRL3/PRR5/IGF1R/PRKAA1/RPS6KB1/FLCN/RRAGB/MIOS/AKT2/LPIN1	3.55286565433736
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	28/1021	138/9376	1.86324859117943	JUN/WASF2/FN1/PIK3R1/ROCK1/TLR4/ROCK2/IKBKB/PKN2/TNF/IRF3/NFATC2/VAV1/GSK3B/WIPF2/ARHGEF1/MAP2K7/WASL/NFATC3/PIK3R3/IRAK1/MAPK14/DOCK1/AKT2/ITGA5/PTK2B/BAIAP2/ARHGEF7	3.57117986775969
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	22/1021	99/9376	2.04070083795843	JUN/WASF2/PIK3R1/DGKZ/PDGFC/DGKH/GPCPD1/EGFR/PCYT1A/TSC2/EIF4EBP1/SP1/SOS1/PLA2G4C/PIK3R3/TSC1/RAF1/PDGFRA/PLPP3/RPS6KB1/AKT2/DGKE	3.63885713728805
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/1021	93/9376	2.07361536760292	WASF2/ROCK1/FGFR1/EP300/ROCK2/MYL9/FER/CTNND1/CSNK2A1/ACTN4/KRIT1/PTPRM/EGFR/TCF7L2/WASL/INSR/IGF1R/VCL/BAIAP2/LMO7/ACTN1	3.63723448886843
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	19/1021	83/9376	2.10216773066802	EP300/MGA/ASXL2/PHC3/MBD5/OGT/KDM2A/MTF2/MBD6/ASXL1/USP7/AUTS2/SFMBT2/CBX6/EZH1/SCML1/HCFC1/CBX4/PCGF3	3.52560823016091
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/1021	122/9376	1.88179380549445	PIK3R1/EP300/NCOR1/ATP1B1/CCND1/MED13L/ITGAV/NCOA1/PLCB2/ATP1A1/NCOA3/MED13/GSK3B/PLCG2/TSC2/PRKACB/MED1/PFKFB2/NCOA2/PIK3R3/RAF1/RCAN1/RXRA/NOTCH1/AKT2	3.42694783392706
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	51/1021	308/9376	1.52058715036188	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/GPX3/RB1CC1/EP300/COX4I1/CREB3L2/NDUFS8/REST/CREB1/PLCB2/HTT/PSMD7/NDUFB7/NDUFS7/NDUFS2/PIK3C3/PSMD1/SOD2/SP1/MAP2K7/PSMD13/NDUFB10/POLR2B/POLR2E/DCTN5/KLC1/POLR2A/ATP5MC1/ATG14/SLC25A4/HIP1/TGM2/RCOR1/NDUFV1/CREB3L1/ATG2A/COX4I2/BECN1/AP2A1	3.24741901163395
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/1021	157/9376	1.75474275875406	MT-CYB/MT-CO3/MT-CO2/MT-CO1/JUN/PIK3R1/MLXIP/COX4I1/IKBKB/TNF/NDUFS8/IL6R/MAP3K11/NDUFB7/ATF4/GSK3B/NDUFS7/NDUFS2/NDUFB10/PPARA/PIK3R3/PRKAG2/INSR/MAPK14/NDUFV1/PRKAA1/RXRA/AKT2/COX4I2/NR1H3	3.33374329942036
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1021	110/9376	1.92011397026088	MKNK1/PIK3R1/EP300/TFRC/TLR4/IGF1/STAT3/EPAS1/LDHB/IL6R/LTBR/PDK1/PLCG2/EGFR/EIF4EBP1/PIK3R3/VHL/PDHB/INSR/FLT1/IGF1R/RPS6KB1/AKT2	3.39325971762222
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	24/1021	117/9376	1.88372385042316	BAZ2B/BPTF/ARID1A/ARID1B/RSF1/BAZ1B/PBRM1/EPC1/CHD4/BAZ2A/SMARCA4/ARID2/BRD9/INO80D/EP400/BRD8/SMARCC2/TRRAP/MBD3/CHD3/INO80/SS18/INO80E/GATAD2B	3.36242609201103
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1021	73/9376	2.13854265895644	AFF4/EP300/RANBP2/CCNT2/SERINC5/BICD1/BICD2/PSIP1/SUPT5H/CCNT1/NUP153/MDFIC/MLLT1/HGS/NELFCD/MAP1B/APOBEC3A	3.41369337362791
Human Diseases	Cancer: specific types	hsa05218	Melanoma	17/1021	73/9376	2.13854265895644	HGF/PIK3R1/FGFR1/IGF1/CCND1/GADD45B/PDGFC/POLK/BRAF/CDK6/EGFR/E2F3/PIK3R3/RAF1/PDGFRA/IGF1R/AKT2	3.41369337362791
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	22/1021	105/9376	1.92408936150366	CFLAR/ATM/TLR4/TNFRSF11A/IKBKB/CD14/TNF/GADD45B/LTBR/CSNK2A1/ERC1/CYLD/PLCG2/EDA/IRAK1/MAP3K14/BCL2L1/CCL13/TRIM25/IL1R1/TRAF5/LTB	3.32866900145815
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1021	99/9376	1.94794170896032	JUN/PIK3R1/NCOR1/IGF1/CCND1/MMP2/NCOA3/BRAF/EGFR/PRKACB/SP1/E2F3/MED1/SOS1/PIK3R3/RAF1/MAPK14/IGF1R/RPS6KB1/NOTCH1/AKT2	3.31452068410949
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1021	68/9376	2.16074206372069	DUSP6/PIK3R1/RUNX1/CCND1/IKBKB/CD14/STAT3/CSF1R/BRAF/EIF4EBP1/TCF7L2/SOS1/PIK3R3/RAF1/RPS6KB1/AKT2	3.35805089558876
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/1021	168/9376	1.69451051723334	CSH1/IL6ST/PIK3R1/PRLR/IL10RA/EP300/IL2RA/PIAS2/CCND1/JAK2/STAT3/IL6R/PIAS1/CSF2RA/CSH2/IL4R/STAT6/IL12RB2/CCND2/EGFR/JAK3/CSF3R/SOS1/PIK3R3/PTPN11/FHL1/RAF1/PDGFRA/IFNAR2/BCL2L1/AKT2	3.17523661884991
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/1021	169/9376	1.68448382778225	VMP1/CFLAR/PIK3R1/RB1CC1/WDFY3/BIRC6/ATG7/UVRAG/ATG4B/TSC2/PIK3C3/PRKACB/PIK3R3/TSC1/DAPK1/RAF1/ATG16L2/ATG14/PLEKHM1/BCL2L1/IGF1R/PRKAA1/RPS6KB1/OPTN/RRAGB/ATG2A/AKT2/MTMR4/SUPT20H/BECN1/STX17	3.13886584542663
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	22/1021	108/9376	1.87064243479523	TPR/PNN/SRRM1/THOC2/RANBP2/UPF2/DDX39B/ACIN1/KPNA6/UPF3A/NUP62/AHCTF1/NUP153/NXF1/UPF3B/IPO9/THOC1/SENP2/XPO4/IPO8/CASC3/TNPO2	3.18114875647164
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/1021	142/9376	1.74609261839401	WWP1/UBE3A/PIAS2/UBE2G2/BIRC6/MGRN1/HERC2/PIAS1/HERC1/ANAPC5/SKP2/CBL/HERC4/FBXW7/CDC27/UBA6/HUWE1/UBE4A/UBR5/VHL/UBE4B/DDB1/SIAH1/ANAPC7/UBA1/RHOBTB1/BIRC7	3.13160705256167
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	27/1021	142/9376	1.74609261839401	JUN/ITPR2/LILRB5/PIK3R1/FOSB/TNFRSF11A/IKBKB/TNF/PPP3CA/NCF4/CSF1R/CREB1/NFATC2/LILRB4/LILRB2/CYLD/PLCG2/ACP5/TEC1/MAP2K7/PIK3R3/IFNAR2/MAPK14/LILRB3/MAP3K14/IL1R1/AKT2	3.13160705256167
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	22/1021	109/9376	1.85348057759527	CD36/PIK3R1/MLXIP/OGA/IKBKB/CREB3L2/STAT3/TNF/CREB1/OGT/GSK3B/PPARA/PIK3R3/PTPN11/PRKAG2/INSR/PRKAA1/CREB3L1/RPS6KB1/AKT2/NR1H3/SLC27A1	3.13301585034301
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1021	77/9376	2.02744953381584	PIK3R1/CCND1/IKBKB/STAT3/GADD45B/ARHGEF6/POLK/BRAF/CDK6/EGFR/E2F3/PIK3R3/RAF1/BCL2L1/BRCA2/RPS6KB1/AKT2	3.16455771187907
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	19/1021	90/9376	1.93866579606051	JUN/PIK3R1/TLR4/IKBKB/JAK2/STAT3/PPP3CA/EML4/CSNK2A1/NFATC2/EGFR/NFATC3/PIK3R3/PTPN11/RAF1/MAP3K3/MAPK14/RPS6KB1/AKT2	3.12783035537439
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	42/1021	253/9376	1.5244761200559	CYTH4/JUN/ITPR2/FOXO3/ATM/WASF2/NAIP/PIK3R1/ROCK1/TLR4/ROCK2/MYL9/IKBKB/CD14/TNF/CCL5/IRF3/PLCB2/ACTN4/GSK3B/PLCG2/EGFR/ARHGEF2/PIK3C3/WASL/PIK3R3/FNBP1L/ATG14/MAPK14/BCL2L1/IL1R1/DOCK1/RPS6KB1/RRAGB/VCL/AKT2/ITGA5/TRAF5/U2AF1/TECPR1/BECN1/ACTN1	2.95625861975414
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1021	59/9376	2.17905343714205	FOXO3/PIK3R1/APC/CCND1/GADD45B/POLK/BRAF/GSK3B/EGFR/TCF7L2/SOS1/PIK3R3/RAF1/AKT2	3.17575308665618
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/1021	91/9376	1.91736177632358	JUN/LILRB5/PIK3R1/IKBKB/PPP3CA/INPP5D/NFATC2/LILRB4/LILRB2/VAV1/GSK3B/PLCG2/SOS1/NFATC3/PIK3R3/RAF1/RASGRP3/LILRB3/AKT2	3.07394197057327
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	21/1021	105/9376	1.83663075416259	JUN/ITPR2/CD209/PIK3R1/IKBKB/TNF/PPP3CA/LSP1/NFATC2/CYLD/PLCG2/EGR2/EGR3/NFATC3/PIK3R3/PTPN11/RAF1/MAPK14/MAP3K14/AKT2/MAPKAPK2	3.0136337166744
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1021	62/9376	2.07361536760292	FOXO3/PIK3R1/IGF1/PRKACB/SOD2/PIK3R3/PRKAG2/INSR/EIF4EBP2/CLPB/IGF1R/PRKAA1/RPS6KB1/AKT2	2.96484319569648
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/1021	122/9376	1.7312503010549	CD36/FOXO3/PIK3R1/IGF1/CCND1/CREB3L2/CREB1/EEF2K/TSC2/EIF4EBP1/PFKFB2/PIK3R3/TSC1/PRKAG2/INSR/STRADA/IGF1R/PRKAA1/PPP2R2A/CREB3L1/MLYCD/RPS6KB1/AKT2	2.84188505254174
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	23/1021	122/9376	1.7312503010549	ITPR2/CSH1/PIK3R1/EP300/IGF1/CREB3L2/JAK2/STAT3/IGFBP3/CREB1/CSH2/PLCB2/ATF6B/ATF4/GSK3B/PLCG2/PRKACB/SOS1/PIK3R3/RAF1/MAPK14/CREB3L1/AKT2	2.84188505254174
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	36/1021	216/9376	1.53052562846882	CD36/POU2F2/JUN/ABCA1/PIK3R1/TLR4/ROCK2/IKBKB/CD14/JAK2/STAT3/TNF/PPP3CA/TLR6/CCL5/NCF4/IRF3/NFATC2/PLCB2/MIB1/ATF4/VAV1/GSK3B/POU2F1/ARHGEF1/SOD2/MAP2K7/NFATC3/PIK3R3/IRAK1/MAPK14/BCL2L1/OLR1/RXRA/AKT2/HSPA2	2.7574699565957
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1021	76/9376	1.93329553069746	PIK3R1/IGF1/CCND1/GADD45B/POLK/BRAF/PLCG2/CDK6/EGFR/E2F3/SOS1/PIK3R3/RAF1/PDGFRA/IGF1R/AKT2	2.85568164500379
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	25/1021	138/9376	1.66361481355307	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/ATP6V0A1/ATP6V0B/COX4I1/ATP6V0D1/NDUFS8/NDUFB7/NDUFS7/NDUFS2/NDUFB10/ATP5MC1/NDUFV1/COX4I2	2.7453133272652
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/1021	77/9376	1.90818779653256	PIK3R1/RUNX1/CCND1/IKBKB/GADD45B/CBL/POLK/BRAF/CDK6/E2F3/SOS1/PIK3R3/PTPN11/RAF1/BCL2L1/AKT2	2.79723003491741
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	15/1021	71/9376	1.94010290932668	FOXO3/PIK3R1/PRLR/CCND1/TNFRSF11A/JAK2/STAT3/GSK3B/CCND2/CGA/SOS1/PIK3R3/RAF1/MAPK14/AKT2	2.77953191121888
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	19/1021	98/9376	1.78040736372904	ITPR2/PIK3R1/DGKZ/PPIP5K2/INPP5D/PIK3C2A/DGKH/PIKFYVE/PLCB2/PLCG2/PIK3C3/INPP4A/PIK3R3/SACM1L/INPP5B/IPMK/CDS2/MTMR4/DGKE	2.71476658205074
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	26/1021	148/9376	1.61325674352119	JUN/PIK3R1/FGFR1/APC/IGF1/CCND1/GADD45B/NCOA1/NCOA3/POLK/BRAF/GSK3B/CDK6/EGFR/SP1/E2F3/TCF7L2/SOS1/PIK3R3/RAF1/WNT2/IGF1R/BRCA2/RPS6KB1/NOTCH1/AKT2	2.62872211870249
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1021	13/9376	3.53198221954343	PRKDC/POLL/MRE11/DCLRE1C/POLM	3.19337630277601
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	29/1021	170/9376	1.5665379961975	HGF/ARID1A/ARID1B/PIK3R1/APC/PBRM1/CCND1/GSTP1/GADD45B/SMARCA4/ARID2/POLK/BRAF/GSK3B/PLCG2/CDK6/EGFR/E2F3/TCF7L2/SMARCC2/SOS1/PIK3R3/RAF1/WNT2/BCL2L1/IGF1R/RPS6KB1/AKT2/GSTM4	2.605813319877
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	36/1021	224/9376	1.47586399888065	NRP1/JUN/ATM/PIK3R1/HLA-DRB5/EP300/IL2RA/CCND1/IKBKB/CREB3L2/TNF/PPP3CA/LTBR/CREB1/ANAPC5/NFATC2/ATF6B/ATF4/DLG1/CCND2/EGR2/CDC27/PRKACB/E2F3/JAK3/NFATC3/PIK3R3/TRRAP/MAP3K3/SLC25A4/MAP3K14/BCL2L1/CREB3L1/IL1R1/ANAPC7/AKT2	2.51984678706641
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/1021	157/9376	1.57926848287866	ITPR2/FOXO3/ATM/PIK3R1/CCND1/IGFBP3/PPP3CA/GADD45B/HIPK3/NFATC2/CCND2/CDK6/TSC2/TRPM7/EIF4EBP1/E2F3/NFATC3/PIK3R3/TSC1/RAF1/SLC25A4/MAPK14/MRE11/AKT2/ZFP36L1/RAD9A/MAPKAPK2	2.55866306892437
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/1021	180/9376	1.53052562846882	POU2F2/PIK3R1/HLA-DRB5/SRSF5/SRSF7/MAVS/IKBKB/JAK2/TNF/SRSF3/CCL5/IRF3/SRSF2/SRSF6/TNFRSF14/TSC2/EIF4EBP1/POU2F1/PIK3R3/PTPN11/TSC1/NXF1/IRAK1/IFNAR2/BCL2L1/HCFC1/EIF2B4/AKT2/ITGA5/TRAF5	2.51228220341919
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/1021	87/9376	1.79440935751517	JUN/PIK3R1/APC/CCND1/GADD45B/POLK/BRAF/GSK3B/EGFR/TCF7L2/SOS1/PIK3R3/RAF1/RPS6KB1/MSH3/AKT2/AREG	2.60222460017543
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1021	101/9376	1.72752397668758	JUN/COL1A1/COL3A1/FN1/PIK3R1/COL1A2/COL4A2/CCND1/JAK2/STAT3/TNF/COL4A1/MMP2/PLCB2/PLCG2/PIK3R3/MAPK14/F3/AKT2	2.56966388378924
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/1021	130/9376	1.62471182098998	JUN/COL1A1/COL3A1/PIK3R1/GNG2/COL1A2/COL4A2/CREB3L2/COL4A1/MMP2/CREB1/PLCB2/ATF6B/ATF4/EGFR/PRKACB/SOS1/MAP2K7/PIK3R3/RAF1/MAPK14/CREB3L1/AKT2	2.5072621099455
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	33/1021	205/9376	1.47826377774062	RBPJ/JUN/PIK3R1/VIM/HLA-DRB5/CCND1/MAVS/IKBKB/STAT3/TNF/IRF3/GADD45B/SKP2/PSMD7/POLK/PLCG2/CCND2/CDK6/USP7/PSMD1/E2F3/JAK3/MAP2K7/PSMD13/PIK3R3/NCOR2/IRAK1/ENTPD1/IFNAR2/MAPK14/MAP3K14/AKT2/TRAF5	2.42025628113702
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1021	75/9376	1.83663075416259	ATM/MDM4/IGF1/CCND1/IGFBP3/ZMAT3/GADD45B/CCND2/CDK6/TSC2/SIVA1/CD82/BCL2L1/SIAH1/GORAB	2.5428744410419
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	26/1021	154/9376	1.5504025846827	JUN/ITPR2/ROCK1/MEF2C/ROCK2/CCND1/MYL9/PPP3CA/KCNJ5/RYR1/NFATC2/PLCB2/EEF2K/TRPM2/EGFR/PRKACB/PLA2G4C/NFATC3/RAF1/PRKAG2/MYLK/RCAN1/PRKAA1/PPP1R12B/CACNB4/PPP1R12C	2.4074293355049
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/1021	50/9376	2.02029382957884	CD36/HBB/HGF/HBA2/CR1/HBA1/LRP1/TLR4/GYPC/TNF/SDC2	2.52864486319398
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/1021	112/9376	1.63984888764517	HLA-DRB5/IL10RA/TLR4/IKBKB/JAK2/STAT3/TNF/ITGA6/LAMC1/LAMB2/IRAK1/LAMB1/MAPK14/LAMA2/LAMA4/BCL2L1/CIITA/AKT2/LAMC3/BIRC7	2.38129082991322
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	21/1021	120/9376	1.60705190989226	JUN/FOXO3/PIK3R1/KIDINS220/IKBKB/ATF4/BRAF/GSK3B/PLCG2/SOS1/MAP2K7/PIK3R3/PTPN11/BEX3/RAF1/IRAK1/MAP3K3/MAPK14/FRS2/AKT2/MAPKAPK2	2.33953777575763
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/1021	250/9376	1.39583937316357	CYTH4/DAB2/WWP1/ZFYVE16/TFRC/IL2RA/USP8/EEA1/ACAP2/DNM1/WASHC4/EHD4/GRK3/CBL/ARAP2/ARFGEF1/EGFR/IQSEC1/WIPF2/RUFY2/RBSN/WASL/RAB11FIP2/SH3GL1/VPS37B/PDGFRA/AGAP3/ARFGAP1/ARFGEF2/IGF1R/MVB12A/VPS45/EPN2/WASHC5/HGS/WASHC1/VPS37A/AP2A1	2.21755318434476
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	31/1021	196/9376	1.4524375862	JUN/ITPR2/IL6ST/PIK3R1/EP300/GNG2/CCND1/IKBKB/JAK2/STAT3/PPP3CA/IRF3/CREB1/NFATC2/GSK3B/PLCG2/CDK6/PIK3C3/E2F3/TCF7L2/MAP2K7/NFATC3/PIK3R3/RAF1/IFNAR2/ATG14/MAPK14/RCAN1/AKT2/BECN1/MAPKAPK2	2.23764225184519
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1021	100/9376	1.65296767874633	CD36/CR1/HLA-DRB5/TFRC/IL2RA/CD14/TNF/CD37/CSF1R/IL6R/CSF2RA/ITGA6/IL4R/CSF3R/CD55/IL1R1/CD9/ITGA5	2.29475643720839
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1021	93/9376	1.67864101186903	RBPJ/JUN/HLA-DRB5/IL2RA/MAML2/IKBKB/JAK2/PPP3CA/NFATC2/IL4R/STAT6/IL12RB2/JAK3/NFATC3/MAPK14/NOTCH1/MAML3	2.29912552336299
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	17/1021	93/9376	1.67864101186903	JUN/ITPR2/MAP3K2/MMP2/PLCB2/ATF4/EGFR/PRKACB/CGA/SOS1/MAP2K7/PLA2G4C/RAF1/MAP3K4/MAP3K3/MAPK14/PTK2B	2.29912552336299
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1021	86/9376	1.70849372480241	JUN/PIK3R1/CBL/ABL2/BRAF/GSK3B/PLCG2/EGFR/EIF4EBP1/SOS1/MAP2K7/PIK3R3/RAF1/RPS6KB1/AKT2/AREG	2.30729252332555
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1021	122/9376	1.58070679661534	JUN/PIK3R1/MAP3K8/IKBKB/TNF/PPP3CA/NFATC2/VAV1/GSK3B/DLG1/TEC1/SOS1/MAP2K7/NFATC3/PIK3R3/PTPN11/RAF1/MAPK14/MAP3K14/PPP2R2A/AKT2	2.25682227115643
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	20/1021	115/9376	1.59707022101094	ITPR2/AKAP13/FGFR1/MEF2A/MEF2C/MAFB/CREB3L2/CREB1/PLCB2/ATF6B/NR4A2/ATF4/BRAF/EGFR/ARHGEF1/PRKACB/SP1/RAF1/RXRA/CREB3L1	2.25201184990487
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	55/1021	388/9376	1.30173571493482	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/APOE/MT-ATP8/ITPR2/MT-ND6/PIK3R1/RB1CC1/LRP1/APC/SLC11A2/COX4I1/IKBKB/TNF/PPP3CA/NDUFS8/CSNK2A1/PLCB2/PSMD7/NDUFB7/ATF4/BRAF/GSK3B/NDUFS7/NDUFS2/PIK3C3/PSMD1/GRIN2C/MAP2K7/PSMD13/NDUFB10/PIK3R3/RAF1/KLC1/WNT2/ATP5MC1/INSR/ATG14/SLC25A4/SNCA/NDUFV1/ATG2A/AKT2/COX4I2/BECN1/SLC39A7	2.12195579092335
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	19/1021	109/9376	1.60073322610501	JUN/SPP1/PIK3R1/TLR4/TLR7/MAP3K8/IKBKB/CD14/TNF/TLR6/CCL5/IRF3/MAP2K7/PIK3R3/IRAK1/IFNAR2/MAPK14/TLR8/AKT2	2.20521329790259
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/1021	109/9376	1.60073322610501	JUN/IL6ST/HLA-DRB5/RUNX1/IL2RA/IKBKB/JAK2/STAT3/PPP3CA/IL6R/NFATC2/IL4R/STAT6/JAK3/NFATC3/MAPK14/RXRA/IL1R1/AHR	2.20521329790259
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	23/1021	139/9376	1.51951465272444	JUN/ITPR2/PIK3R1/CREB3L2/KCNJ5/MMP2/CREB1/FKBP5/NCOA1/KRT18/PLCB2/ATF6B/NCOA3/ATF4/EGFR/PRKACB/SP1/SOS1/NCOA2/PIK3R3/RAF1/CREB3L1/AKT2	2.15707383849095
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1021	34/9376	2.16074206372069	PER3/CSNK1D/CREB1/NR1D2/PER1/PRKAG2/PRKAA1/CLOCK	2.37017565031804
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	18/1021	103/9376	1.6048229890741	FUS/SMG1/PNN/SRRM1/PCF11/UPF2/DDX39B/ACIN1/RNMT/UPF3A/SMG6/PABPN1/NXF1/UPF3B/SYMPK/FIP1L1/PPP2R2A/CASC3	2.15755589059348
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1021	155/9376	1.48115383400209	CD36/CD209/ATP6V0A1/MRC1/HLA-DRB5/DYNC1H1/ATP6V0B/TFRC/TLR4/EEA1/CD14/ATP6V0D1/TLR6/NCF4/DYNC1LI2/ITGAV/PIKFYVE/SCARB1/PIK3C3/SEC61A1/FCAR/OLR1/HGS/ITGA5/DYNC2H1	2.11147561862274
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	31/1021	201/9376	1.41630729798607	FUS/REL/JMJD1C/DUSP6/ATM/KMT2A/NUPR1/RUNX1/EWSR1/MEF2C/NCOR1/IGF1/CD14/IGFBP3/CSF1R/GADD45B/LYL1/CCNT2/TAF15/POLK/CCND2/BCL6/SP1/CCNT1/FLT1/SS18/MLLT1/BCL2L1/IGF1R/PROM1/RXRA	2.08561575379869
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	52/1021	368/9376	1.29761955457139	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/FUS/MT-ATP8/MT-ND6/SETX/HNRNPA2B1/GPX3/TPR/RB1CC1/ATXN2/COX4I1/RANBP2/SRSF7/TNF/PPP3CA/SRSF3/NDUFS8/PSMD7/NDUFB7/ATF4/NDUFS7/NDUFS2/PIK3C3/PSMD1/GRIN2C/NUP62/PSMD13/NDUFB10/NUP153/CCS/NXF1/DCTN5/KLC1/ATP5MC1/ATG14/MAPK14/BCL2L1/NDUFV1/OPTN/ATG2A/COX4I2/BECN1	2.03608762842776
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1021	17/9376	2.70092757965086	CD209/NRP2/TFRC/MYH10/DAG1	2.4536964933111
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/1021	119/9376	1.54338718837192	JUN/CFLAR/PIK3R1/MAP3K8/IKBKB/CREB3L2/TNF/CCL5/CREB1/ATF6B/ATF4/CYLD/DNM1L/MAP2K7/PIK3R3/MAPK14/MAP3K14/CREB3L1/AKT2/TRAF5	2.08532152282203
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1021	69/9376	1.73015940609519	ALOX5AP/PIK3R1/TNF/INPP5D/VAV1/PLCG2/SOS1/MAP2K7/PLA2G4C/PIK3R3/RAF1/MAPK14/AKT2	2.12795605416704
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1021	70/9376	1.70544284315097	JUN/HGF/PIK3R1/EP300/EPAS1/BRAF/SOS1/PIK3R3/PTPN11/VHL/RAF1/FLCN/AKT2	2.07087845520596
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/1021	144/9376	1.46675372728262	TRA2B/FOXO3/TLR4/CCND1/IKBKB/CD14/TNF/IRF3/LPIN2/GSK3B/IL17RA/TCF7L2/MAP2K7/PPARA/IRAK1/PRKAG2/MAPK14/MAP3K14/PRKAA1/MLYCD/AKT2/ACADM/LPIN1	1.97308786236207
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/1021	144/9376	1.46675372728262	RBPJ/ITPR2/PIK3R1/RB1CC1/ATXN2/PUM1/RYR1/ATXN1/PLCB2/PSMD7/AFG3L2/PIK3C3/PSMD1/GRIN2C/SP1/PSMD13/PIK3R3/ATG14/SLC25A4/ATG2A/AKT2/ATXN3/BECN1	1.97308786236207
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1021	30/9376	2.14273587985635	IKBKB/TNF/MTHFR/ABCC5/MTR/SLC46A1/ABCG2	2.19138601029587
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1021	44/9376	1.87837236221174	DYNC1H1/CREB3L2/VAMP2/CREB1/DYNC1LI2/PRKACB/DCTN5/CREB3L1/DYNC2H1	2.0414696024782
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/1021	155/9376	1.421907680642	ITPR2/KMT2A/APC/USP8/CCND1/CREB3L2/CREB1/NR4A1/PLCB2/ATF6B/ATF4/BRAF/GSK3B/CDK6/EGFR/SCARB1/PRKACB/SP1/E2F3/TCF7L2/KMT2D/WNT2/CREB3L1/AHR	1.85148224545041
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	36/1021	250/9376	1.32237414299706	ATP6V0A1/VPS13C/MCOLN1/ATP6V0B/SLC11A2/TLR7/TPP1/TPCN1/DMXL2/ATP6V0D1/GGA1/NEU1/CLN6/HGSNAT/PIKFYVE/GPR155/NPC1/AP3D1/CLN8/BORCS7/ACP5/CLCN7/VPS13A/OSBPL3/AP5Z1/SLC11A1/PLEKHM1/CTSO/ENTPD4/TLR8/RRAGB/GLA/KXD1/AP2A1/AP4E1/STX17	1.80598964079844
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/1021	156/9376	1.41279288781737	CFLAR/PIK3R1/CCND1/MAVS/IKBKB/STAT3/TNF/IRF3/PIAS1/BRAF/GSK3B/CDK6/EGFR/SCARB1/E2F3/SOS1/PPARA/PIK3R3/RAF1/IFNAR2/RXRA/PPP2R2A/AKT2/NR1H3	1.81741591498595
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/1021	243/9376	1.32267646904713	TRA2B/FUS/RBM25/PRPF38B/HNRNPU/DDX46/SNRNP70/SF3B1/U2SURP/SF1/THOC2/SRSF5/RBMX/SRSF7/DDX39B/SRSF3/ACIN1/TCERG1/SRSF10/SRSF2/SRSF6/SNRPD2/DDX42/PRPF6/SNRNP200/CWC25/CCDC12/PRPF3/PQBP1/THOC1/CASC3/DHX38/U2AF1/CHERP/PRPF38A	1.78151295990872
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1021	32/9376	2.00881488736533	HADHA/ACSS1/LDHB/DBT/MLYCD/ABAT/ACADS	1.99822937494481
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1021	60/9376	1.6835781913157	HSPB1/PIK3R1/PPP3CA/NFATC2/PLCG2/PLA2G4C/PIK3R3/RAF1/MAPK14/AKT2/MAPKAPK2	1.85683949951418
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	25/1021	166/9376	1.3830050859658	ITPR2/ATP2B1/ROCK1/MEF2A/MEF2C/ATP1B1/ROCK2/MYL9/CREB3L2/PPP3CA/ADRB2/ATP2B4/CREB1/NFATC2/PLCB2/ATP1A1/ATF6B/ATF4/NFATC3/RAF1/INSR/SLC25A4/MYLK/CREB3L1/AKT2	1.74041994696144
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/1021	238/9376	1.31187911011613	REL/HGF/PIK3R1/FGFR1/GNG2/IGF1/PLA2G2A/IKBKB/RASA1/CSF1R/NF1/PDGFC/ABL2/PLCG2/EGFR/PRKACB/RGL2/RALGAPA2/SOS1/RALGAPA1/PLA2G4C/PIK3R3/RASA2/PTPN11/RAF1/PDGFRA/INSR/RASGRP3/FLT1/RALGAPB/TIAM1/BCL2L1/IGF1R/AKT2	1.70362682656189
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1021	75/9376	1.59174665360757	ATM/PIK3R1/GSTP1/XPA/TOP2B/ATP7A/REV3L/SLC31A1/PIK3R3/BCL2L1/MSH3/AKT2/GSTM4	1.79856816587734
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1021	75/9376	1.59174665360757	ITPR2/GPX3/ATP1B1/CREB3L2/CREB1/PLCB2/ATP1A1/ATF6B/ATF4/PRKACB/CGA/CREB3L1/TTF1	1.79856816587734
Human Diseases	Infectious disease: viral	hsa05162	Measles	21/1021	136/9376	1.4179869793167	JUN/CD209/PIK3R1/IL2RA/TLR4/TLR7/CCND1/MAVS/IKBKB/STAT3/IRF3/CSNK2A1/GSK3B/CCND2/CDK6/JAK3/PIK3R3/IRAK1/IFNAR2/BCL2L1/AKT2	1.71641184920697
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	22/1021	144/9376	1.40298182609642	ZFHX3/IL6ST/PIK3R1/FGFR1/APC/RIF1/KAT6A/IGF1/JAK2/STAT3/REST/SMAD5/GSK3B/JAK3/PIK3R3/RAF1/WNT2/MAPK14/SMARCAD1/IGF1R/AKT2/PCGF3	1.70350766013681
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/1021	98/9376	1.49929041156129	ITPR2/ATP2B1/ATP1B1/CREB3L2/KCNJ5/ATP2B4/CREB1/NR4A1/PLCB2/ATP1A1/ATF6B/NR4A2/ATF4/SCARB1/PRKACB/CREB3L1	1.73685819360821
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/1021	248/9376	1.29600960475182	CYTH4/JUN/AHNAK/NAIP/GCC2/NCKAP1L/DYNC1H1/TLR4/ROCK2/MYL9/IKBKB/CD14/TNF/TLR6/S100A10/SNX18/PIK3C2A/FLNA/DYNC1LI2/GSDMD/PIK3C3/TCF7L2/MAP2K7/WASL/EXOC7/EXOC4/RAF1/DCTN5/KLC1/IRAK1/MAPK14/PLEKHM1/FHOD1/AKT2/DYNC2H1	1.65146399562991
NA	NA	hsa04517	IgSF CAM signaling	41/1021	299/9376	1.2592284434894	NRP1/CD84/CD209/PIK3R1/SRGAP3/FGFR1/NRP2/MTSS1/SRGAP1/MYL9/PMP22/INPP5D/RASA1/CASK/EPB41L1/ACTN4/ERC1/SPTBN1/VAV1/GSK3B/PLCG2/CADM3/MAGI1/WASL/RAPGEF6/PIK3R3/SLITRK4/PTPN11/MAPK14/MYLK/SPTAN1/MYH10/VCL/AKT2/CSK/ITGA5/CLMP/BAIAP2/LMO7/TRIO/ACTN1	1.59247403786664
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1021	21/9376	2.18646518352689	CSGALNACT1/CHSY1/CSGALNACT2/B3GAT3/CHST11	1.90268998430408
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	21/1021	138/9376	1.39743644338458	MKNK1/PIK3R1/IKBKB/PRKAR2A/PHKB/CBL/BRAF/GSK3B/TSC2/EIF4EBP1/PRKACB/SOS1/EXOC7/PIK3R3/TSC1/RAF1/PRKAG2/INSR/PRKAA1/RPS6KB1/AKT2	1.64415793993922
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/1021	116/9376	1.42497213685028	ARHGAP5/PIK3R1/ROCK1/ROCK2/MYL9/MMP2/NCF4/CTNND1/ACTN4/VAV1/ARHGAP35/PLCG2/PIK3R3/PTPN11/MAPK14/VCL/PTK2B/ACTN1	1.6099383287859
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	13/1021	78/9376	1.53052562846882	PPIP5K2/INPP5D/PIK3C2A/PIKFYVE/PLCB2/PLCG2/PIK3C3/INPP4A/SACM1L/INPP5B/IPMK/ISYNA1/MTMR4	1.64469048933988
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1021	56/9376	1.63984888764517	CCND1/MGRN1/DISP1/CSNK1D/GRK3/GSK3B/CCND2/PRKACB/MEGF8/CSNK1G1	1.67876056457052
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/1021	49/9376	1.68670171300646	JUN/FOSB/CREB3L2/CREB1/ATF6B/ATF4/PRKACB/GRIN2C/CREB3L1	1.68469180978117
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1021	71/9376	1.55208232746134	JUN/ATP6V0A1/ATP6V0B/IKBKB/ATP6V0D1/CCL5/PLCG2/EGFR/PTPN11/MAPK14/MAP3K14/CSK	1.63230049771663
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/1021	149/9376	1.3559018990462	CYTH4/PIK3R1/DGKZ/DNM1/PDGFC/DGKH/PLCB2/PLCG2/EGFR/TSC2/SOS1/PLA2G4C/PIK3R3/PTPN11/TSC1/RAF1/PDGFRA/PLPP3/INSR/AKT2/PTK2B/DGKE	1.53080002758349
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	23/1021	157/9376	1.34530278171145	CD36/STAB1/ABCA1/LRP1/TMEM30A/JAK2/DNMT3A/CREB1/PROS1/VPS8/NFATC2/ITGAV/MFGE8/NFATC3/ATP11C/PTPN11/MAPK14/TGFBRAP1/RXRA/DOCK1/S1PR1/NR1H3/MAPKAPK2	1.52522276159639
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1021	103/9376	1.42650932362143	COL1A1/COL6A2/COL3A1/COL6A1/COL1A2/ATP1B1/COL4A2/COL4A1/SLC38A2/COL15A1/SLC7A8/ATP1A1/COL14A1/COL5A1/COL6A3/DPP4	1.52146614827119
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1021	65/9376	1.55407217659911	ITPR2/CREB3L2/CREB1/NR4A1/PLCB2/ATF6B/ATF4/SCARB1/PRKACB/SP1/CREB3L1	1.56693196165633
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1021	37/9376	1.73735341609974	HBB/HBA2/HBA1/TNF/PLCB2/LAMA4/APOL1	1.57091126162832
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1021	37/9376	1.73735341609974	TPR/CCND1/GADD45B/POLK/BRAF/TCF7L2/RXRA	1.57091126162832
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	36/1021	268/9376	1.23355796921368	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/MT-ATP8/ITPR2/MT-ND6/SLC11A2/COX4I1/UBE2G2/NDUFS8/PSMD7/NDUFB7/ATF4/NDUFS7/NDUFS2/PRKACB/PSMD1/PSMD13/NDUFB10/KLC1/ATP5MC1/SLC25A4/SNCA/BCL2L1/NDUFV1/UBA1/COX4I2/SLC39A7	1.35605048563915
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1021	52/9376	1.58939199879455	CD36/APOE/PLTP/APOC1/ABCA1/LRP1/MYLIP/NPC1/SCARB1	1.48980716073885
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	61/1021	480/9376	1.16702579170748	MT-CYB/MT-CO3/MT-ND1/MT-ATP6/MT-ND4/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND3/MT-ND4L/FUS/MT-ATP8/ITPR2/MT-ND6/GPX3/RB1CC1/APC/ATXN2/COX4I1/UBE2G2/TNF/PPP3CA/NDUFS8/RYR1/CSNK2A1/ATXN1/PLCB2/HTT/PSMD7/NDUFB7/ATF4/BRAF/GSK3B/NDUFS7/NDUFS2/PIK3C3/PSMD1/GRIN2C/MAP2K7/PSMD13/NDUFB10/CCS/RAF1/DCTN5/KLC1/WNT2/ATP5MC1/ATG14/SLC25A4/MAPK14/HIP1/SNCA/BCL2L1/NDUFV1/UBA1/OPTN/ATG2A/ATXN3/COX4I2/BECN1	1.31320356392365
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1021	31/9376	1.7773846008025	SEC63/SRP72/OXA1L/SEC61A1/TMEM208/SGTA	1.51548767815486
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1021	99/9376	1.39138693497166	TPM1/IGF1/TNF/ITGAV/ITGA6/TTN/TPM2/PRKAG2/DES/LAMA2/DTNA/PRKAA1/CACNB4/ITGA5/DAG1	1.3685019650381
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1021	107/9376	1.37318187227109	ITPR2/EP300/CREB3L2/PPP3CA/LDHB/PHKB/CREB1/PLCB2/ATF4/PRKACB/PPARA/PDHB/PRKAG2/PRKAA1/CREB3L1/AKT2	1.35712943204752
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	32/1021	238/9376	1.23470975069754	NRP1/JUN/RPL13A/IL6ST/PIK3R1/RPS20/RPL7/RPS11/C7/TLR4/TLR7/RPS26/MAVS/IKBKB/STAT3/TNF/F13A1/RPL31/RPL23/IRF3/IL6R/RPS14/RPLP2/RPS8/PLCG2/EGFR/PIK3R3/RPL27A/IRAK1/IFNAR2/MAPK14/TLR8	1.28209237096734
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1021	61/9376	1.50543504439556	ATP2B1/SLC40A1/SLC11A2/ATP1B1/ATP2B4/ATP1A1/ATP7A/TRPM7/SLC31A1/SLC46A1	1.38440806451993
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1021	54/9376	1.53052562846882	BCAT1/LDHB/DNMT3A/AMD1/MAT2A/DNMT1/AHCYL1/MTR/GCLC	1.36670247611431
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/1021	62/9376	1.48115383400209	RBPJ/SPEN/EP300/TLE4/MAML2/ATXN1/NCOR2/NOTCH1/MAML3/DTX2	1.32873067382542
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	24/1021	174/9376	1.26664189942247	RRBP1/UBXN4/MAN1A1/UBE2G2/SEC63/PPP1R15A/PRKCSH/BCAP31/SEC31A/MBTPS1/ATF6B/ATF4/MAN1A2/WFS1/DNAJB11/NPLOC4/MAP2K7/SEC61A1/CKAP4/UBE4B/ATXN3/UBXN6/UBXN2A/UGGT2	1.24104401973645
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1021	12/9376	2.29578844270323	COQ7/COQ4/VKORC1L1	1.57007104593738
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1021	70/9376	1.44306702112775	CD36/IKBKB/JAK2/STAT3/TNF/PPARA/PTPN11/PRKAG2/PRKAA1/RXRA/AKT2	1.30065526523369
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/1021	158/9376	1.2786669807461	ATRX/ATM/NIPBL/EP300/PRKDC/CCND1/WAPL/SMC3/GADD45B/CCNH/ANAPC5/SKP2/PDS5A/GSK3B/CCND2/CDK6/CDC27/E2F3/HDAC8/ANAPC7/MAU2/CDC14A	1.23486927759113
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/1021	78/9376	1.41279288781737	DHX36/DCP2/BTG1/DDX6/CNOT2/CNOT4/CNOT1/PARN/DIS3L/DIS3/EXOSC10/EXOSC8	1.27970544725584
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/1021	110/9376	1.33573145757279	DCN/ROCK1/ZFYVE16/EP300/TFRC/NCOR1/TNF/EMP3/FBN1/SMAD5/HFE/SP1/BMP5/LEMD3/PITX2/RPS6KB1	1.23813360924987
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1021	33/9376	1.66966432196599	BCAT1/DHTKD1/OGDH/PDHB/IDH3B/DBT	1.34708884264282
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1021	33/9376	1.66966432196599	STX16/VAMP2/STX3/VTI1A/VAMP5/STX17	1.34708884264282
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1021	19/9376	1.93329553069746	DHTKD1/OGDH/PDHB/DBT	1.42348519292231
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/1021	48/9376	1.53052562846882	BCAT1/HADHA/IVD/ACSF3/DBT/ABAT/ACADS/ACADM	1.28812497477101
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1021	41/9376	1.56785552184611	CCND1/MMP2/BRAF/EGFR/E2F3/DAPK1/RAF1	1.27379019793308
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/1021	104/9376	1.32449333232879	DGKZ/PLA2G2A/LPIN2/DGKH/LPGAT1/GPCPD1/PCYT1A/PLA2G4C/PLPP3/SAMD8/CDS2/LPCAT3/LPIN1/PTDSS2/DGKE	1.16321774205102
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/1021	57/9376	1.44997164802309	TECR/HADHA/HSD17B12/ACSF3/HACD3/CBR4/ACADS/ACADM/FADS1	1.19114108473824
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/1021	187/9376	1.22769435438676	JUN/ITPR2/NAIP/TLR4/MAVS/IKBKB/PKN2/TNF/CCL5/IRF3/PLCB2/CARD8/TRPM2/DNM1L/TRPM7/GSDMD/P2RX7/ANTXR1/PSTPIP1/IFNAR2/MAPK14/BCL2L1/DHX33/TRAF5/NLRP1	1.09942149118682
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	24/1021	181/9376	1.21765574861608	CD209/CR1/ATP6V0A1/MRC1/HLA-DRB5/IL10RA/EP300/ATP6V0B/TLR4/EEA1/CD14/JAK2/ATP6V0D1/TNF/PPP3CA/LSP1/TLR6/CREB1/PIK3C3/RAF1/IRAK1/MAPK14/CIITA/AKT2	1.03361509886178
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/1021	173/9376	1.22088171519478	PIK3R1/HLA-DRB5/EP300/TLR4/TLR7/MAVS/IKBKB/JAK2/TNF/CCL5/IRF3/KPNA6/HNRNPUL1/CDK6/PIK3R3/PABPN1/NXF1/RAF1/IFNAR2/SLC25A4/CIITA/TRIM25/AKT2	1.02504607900297
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1021	21/9376	1.74917214682151	BCAT1/ENPP1/PANK3/CSAD	1.20141944329087
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1021	44/9376	1.46095628172024	CCNH/TAF3/TAF15/TAF1/TAF7/TAF11/TAF2	1.07133179240037
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1021	44/9376	1.46095628172024	POLE/PARG/POLL/PNKP/POLD3/NEIL1/TDG	1.07133179240037
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1021	52/9376	1.41279288781737	IGF1/SCARB1/PRKACB/CGA/PLA2G4C/HSD17B2/INSR/IGF1R	1.04341728667879
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/1021	184/9376	1.19780266575821	NRP1/PIK3R1/SRGAP3/ROCK1/SRGAP1/ROCK2/MYL9/PPP3CA/LRRC4/PLXNB2/RASA1/NFATC2/GSK3B/PLCG2/EPHB3/NFATC3/PIK3R3/PTPN11/RAF1/SEMA3D/LRIG2/SSH1/ENAH/SEMA6D	0.947242828648075
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	25/1021	193/9376	1.18952769051981	FOXO3/CXCL14/PIK3R1/ROCK1/GNG2/ROCK2/IKBKB/JAK2/STAT3/CCL5/GRK3/PLCB2/VAV1/BRAF/GSK3B/PLCG2/PRKACB/JAK3/SOS1/PIK3R3/RAF1/TIAM1/CCL13/AKT2/PTK2B	0.930002926201014
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1021	126/9376	1.2389969373319	COL1A1/ITPR2/COL3A1/PIK3R1/ROCK1/COL1A2/ROCK2/PLCB2/ARHGAP35/PLCG2/ARHGEF1/PRKACB/PLA2G4C/PIK3R3/MAPK14/MYLK/AKT2	0.944130491910207
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1021	69/9376	1.33089185084245	JUN/FOSB/CREB3L2/PPP3CA/CREB1/ATF6B/ATF4/PRKACB/GRIN2C/CREB3L1	0.964341911364681
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1021	53/9376	1.38613641823591	ATP2B1/ATP1B1/DNM1/ATP2B4/PLCB2/ATP1A1/PRKACB/AP2A1	0.985430814582381
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/1021	212/9376	1.16955260288655	HGF/PIK3R1/FGFR1/IGF1/EVL/CSF1R/CTNND1/PDGFC/PLCB2/KRIT1/VAV1/BRAF/SIPA1L2/EGFR/MAGI1/RAPGEF6/PIK3R3/RAF1/PDGFRA/INSR/RASGRP3/MAPK14/FLT1/TIAM1/IGF1R/AKT2/ENAH	0.872881187447104
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/1021	170/9376	1.18840813504638	JUN/ROCK1/RUNX1/ROCK2/CCND1/MYL9/ACTN4/DLG1/RAB13/ARHGEF2/PRKACB/MAGI1/MAP2K7/ARHGAP17/RAPGEF6/PRKAG2/SYMPK/TIAM1/MYH10/PRKAA1/PPP2R2A/ACTN1	0.866590469081066
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/1021	103/9376	1.24819565816875	JUN/CFLAR/PIK3R1/TLR4/IKBKB/TNF/TLR6/CCL5/PLCB2/PIK3R3/IRAK1/MAPK14/PPP2R2A/AKT2	0.88537640594891
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1021	38/9376	1.44997164802309	PIK3R1/ATP1B1/IGF1/ATP1A1/PIK3R3/INSR	0.971572684183255
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/1021	87/9376	1.26664189942247	MT-CYB/MT-CO3/MT-CO2/MT-CO1/TPM1/ASPH/ATP1B1/COX4I1/ATP1A1/TPM2/CACNB4/COX4I2	0.873431441297456
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1021	23/9376	1.59707022101094	PCYOX1/FNTA/DHDDS/ZMPSTE24	1.00216479916302
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1021	71/9376	1.29340193955112	PIK3R1/FGFR1/LDHB/PDK1/EGFR/PIK3R3/PDHB/RAF1/PDGFRA/AKT2	0.867479555381801
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/1021	63/9376	1.31187911011613	UVSSA/XPA/CCNH/POLE/POLR2B/POLR2E/POLR2A/DDB1/POLD3	0.868234505735707
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1021	31/9376	1.48115383400209	HADHA/MLYCD/ABAT/CSAD/ACADS	0.937994791734214
NA	NA	hsa04981	Folate transport and metabolism	5/1021	31/9376	1.48115383400209	MTHFR/ABCC5/MTR/SLC46A1/ABCG2	0.937994791734214
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1021	55/9376	1.33573145757279	NEU1/ACER3/DEGS1/UGCG/PLPP3/SAMD8/B4GALT5/GLA	0.872905859642714
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1021	105/9376	1.22442050277506	TPM1/IGF1/TNF/ITGAV/ITGA6/TTN/PRKACB/TPM2/DES/LAMA2/DTNA/CACNB4/ITGA5/DAG1	0.808386723188162
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1021	217/9376	1.14260438623018	JUN/PIK3R1/EPHX1/CCND1/CREB3L2/JAK2/STAT3/ADRB2/KPNA6/CREB1/ATF6B/ATF4/EGFR/EIF4EBP1/PRKACB/BCL6/SOS1/PPARA/PIK3R3/RAF1/RXRA/CREB3L1/RPS6KB1/PAQR7/AKT2/AHR/GSTM4	0.742957554976485
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1021	32/9376	1.43486777668952	ATG7/ATG4B/PIK3C3/ATG2A/BECN1	0.86137266259757
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/1021	149/9376	1.1710061855399	MT-ND1/MT-ND4/MT-ND5/MT-ND2/MT-ND3/MT-ND4L/ITPR2/MT-ND6/GNG2/KCNJ5/NDUFS8/PLCB2/NDUFB7/NDUFS7/NDUFS2/PRKACB/NDUFB10/MAPK14/NDUFV1	0.735529296817401
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1021	65/9376	1.27151359903564	ITPR2/SPP1/PIK3R1/KCNJ5/PLCB2/CGA/PIK3R3/RAF1/AKT2	0.767848223248903
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/1021	142/9376	1.164061745596	JUN/PIK3R1/MEF2A/MEF2C/IKBKB/TNF/GSTP1/MMP2/ITGAV/ARHGEF2/MAP2K7/PIK3R3/SDC2/MAPK14/PRKAA1/IL1R1/AKT2/GSTM4	0.688623512547213
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1021	67/9376	1.23355796921368	ITPR2/EP300/PPP3CA/PLCB2/ATF4/BRAF/PRKACB/GRIN2C/RAF1	0.670665334071222
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1021	42/9376	1.31187911011613	SLC40A1/SLC11A2/TFRC/ATG7/GCLC/LPCAT3	0.708112588971449
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1021	34/9376	1.35046378982543	POLR2B/POLR2E/POLR2A/POLR1A/CRCP	0.715629050522889
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1021	59/9376	1.2451733926526	PIK3R1/ADRB2/PRKACB/CGA/PIK3R3/INSR/PNPLA2/AKT2	0.660368846699404
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1021	18/9376	1.53052562846882	NEU1/MAN2C1/MAN2B2	0.787546820972122
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1021	18/9376	1.53052562846882	ABCD4/MTR/HCFC1	0.787546820972122
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1021	26/9376	1.41279288781737	ABCD4/SCARB1/SLC46A1/SLC19A3	0.736780896356916
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/1021	137/9376	1.13951543141474	JUN/CFLAR/ITPR2/ATM/PIK3R1/IKBKB/TNF/GADD45B/ATF4/PIK3R3/DFFA/RAF1/SPTAN1/MAP3K14/CTSO/BCL2L1/AKT2	0.575036389377987
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1021	43/9376	1.2813702936018	CD36/ABCA1/PLA2G2A/SCARB1/PLPP3/SLC27A1	0.646438361426056
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1021	60/9376	1.22442050277506	ITPR2/IGF1/RYR1/PLCB2/BRAF/PLA2G4C/RAF1/IGF1R	0.609605249768865
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1021	86/9376	1.17458943580165	DSC2/GJA1/ITGAV/ITGA6/TCF7L2/DES/LAMA2/DTNA/CACNB4/ITGA5/DAG1	0.568570878999851
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/1021	95/9376	1.15997731841848	JUN/ATP6V0A1/HLA-DRB5/ATP6V0B/TLR4/TNFRSF11A/ATP6V0D1/TNF/CCL5/ACP5/FLT1/LTB	0.547832901286781
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1021	27/9376	1.36046722530562	HADHA/ACSM5/ABAT/ACADS	0.655677631450348
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1021	27/9376	1.36046722530562	TECR/HSD17B12/HACD3/FADS1	0.655677631450348
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/1021	78/9376	1.17732740651448	WASF2/FN1/PIK3R1/DNM1/CBL/WASL/PIK3R3/DOCK1/VCL/ITGA5	0.549735363087759
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1021	140/9376	1.11509724359871	ITPR2/SPP1/MEF2A/MEF2C/GNG2/CCND1/RYR1/PLCB2/PIK3C3/PRKACB/RAF1/PRKAG2/MYLK/PRKAA1/RPS6KB1/AKT2/BECN1	0.479636539458615
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/1021	105/9376	1.13696189543398	JUN/FOXO3/USP8/CSNK2A1/ATF4/MON1B/HUWE1/SP1/RHOT2/BCL2L1/SIAH1/OPTN/BECN1	0.493351438404413
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1021	28/9376	1.31187911011613	TECR/HADHA/HSD17B12/HACD3	0.577738397301141
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1021	45/9376	1.22442050277506	ABCA1/ABCA6/ABCD4/ABCA9/ABCC5/ABCG2	0.527509123439277
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1021	150/9376	1.10197845249755	HGF/PIK3R1/APC/CCND1/GADD45B/POLK/BRAF/GSK3B/EGFR/E2F3/TCF7L2/SOS1/PIK3R3/RAF1/WNT2/RXRA/RPS6KB1/AKT2	0.440121519701009
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/1021	133/9376	1.10474030325569	ITPR2/GNG2/CREB3L2/PPP3CA/KCNJ5/CREB1/PLCB2/ATF6B/ATF4/GSK3B/PRKACB/MAPK14/PPP2R2A/CREB3L1/CLOCK/AKT2	0.425263836735469
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/1021	89/9376	1.13499653347126	ITPR2/MAP3K2/CSNK1D/PDGFC/GJA1/PLCB2/EGFR/PRKACB/SOS1/RAF1/PDGFRA	0.447306469187548
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/1021	98/9376	1.12446780867097	WASF2/PIK3R1/INPP5D/VAV1/PLCG2/PLA2G4C/PIK3R3/RAF1/PLPP3/DOCK1/RPS6KB1/AKT2	0.432980342351509
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1021	12/9376	1.53052562846882	CD209/NPC1	0.642823242541759
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	21/1021	178/9376	1.08340578194984	JUN/APC/EP300/TLE4/ROCK2/CCND1/SERPINF1/PPP3CA/CHD8/CSNK2A1/DAAM1/NFATC2/PLCB2/GSK3B/CCND2/PRKACB/TCF7L2/NFATC3/WNT2/SENP2/SIAH1	0.392721555264826
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1021	72/9376	1.14789422135162	DDX3X/MAVS/IKBKB/TNF/IRF3/CYLD/RNF125/MAPK14/TRIM25	0.440360021941317
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/1021	214/9376	1.07279833771179	JUN/ITPR2/ATM/PIK3R1/GNG2/TLR4/IKBKB/TNF/PPP3CA/IRF3/NFATC2/PLCG2/MAP2K7/NFATC3/PIK3R3/RAF1/IRAK1/MAPK14/BCL2L1/DDB1/RPS6KB1/AKT2/TRAF5/PTK2B/APOBEC3A	0.376581072320191
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/1021	134/9376	1.09649597263438	ITPR2/CALD1/ROCK1/ROCK2/MYL9/PLA2G2A/PLCB2/BRAF/ARHGEF1/PRKACB/PLA2G4C/RAF1/MYLK/MYH10/PPP1R12B/PPP1R12C	0.39328183464952
NA	NA	hsa04519	Cadherin signaling	46/1021	404/9376	1.0456066174688	PCDH12/MYO1F/ROCK1/VIM/FGFR1/NCKAP1L/APC/EP300/TAOK1/FMN1/ROCK2/EVL/RERE/IKBKB/DSC2/TMC6/CTNND1/DAAM1/TMC8/GJA1/KRT18/ACTN4/VAV1/ARHGAP35/LIMD1/GSK3B/ABI2/EGFR/MYO7A/KRT7/TCF7L2/RAF1/WNT2/LIMA1/STK3/PDGFRA/MAPK14/DES/IGF1R/CDH11/VCL/MYO1C/KRT8/ENAH/PTK2B/ACTN1	0.327566284844833
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1021	38/9376	1.20830970668591	AMDHD2/RENBP/GPI/PGM3/UAP1L1	0.449779495564731
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1021	38/9376	1.20830970668591	ENPP1/NT5C2/QPRT/NT5C/NAPRT	0.449779495564731
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	18/1021	154/9376	1.07335563554956	TPM1/ATP2B1/ATP1B1/CREB3L2/ADRB2/ATP2B4/CREB1/PLCB2/ATP1A1/ATF6B/ATF4/PRKACB/TPM2/MAPK14/PPP2R2A/CREB3L1/CACNB4/AKT2	0.320853342373801
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1021	65/9376	1.1302343102539	DGKZ/LPIN2/DGKH/PLPP3/PNPLA2/GLA/LPIN1/DGKE	0.368306354045189
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	13/1021	110/9376	1.08528180927789	CPEB4/PIK3R1/IGF1/ANAPC5/BRAF/CDC27/PRKACB/PIK3R3/RAF1/MAPK14/IGF1R/ANAPC7/AKT2	0.314508134233153
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	29/1021	254/9376	1.04847031241565	ITPR2/HGF/HRH1/ATP2B1/MCOLN1/FGFR1/ASPH/TPCN1/PPP3CA/ADRB2/ATP2B4/PHKB/RYR1/PDGFC/NFATC2/PLCB2/CYSLTR1/PLCG2/EGFR/P2RX7/PRKACB/GRIN2C/NFATC3/PDGFRA/SLC25A4/MYLK/FLT1/HRH2/PTK2B	0.273761849008573
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/1021	200/9376	1.05606268364349	CYTH4/JUN/WASF2/NAIP/MYO1F/ROCK1/NCKAP1L/MYO5A/TLR4/ROCK2/IKBKB/TNF/ARHGEF2/WIPF2/ARHGEF1/WASL/PTPN11/IRAK1/MAPK14/MYH10/IL1R1/MYO1C/BAIAP2	0.280147957532053
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1021	48/9376	1.14789422135162	PIK3R1/ATP1B1/PLCB2/ATP1A1/PIK3R3/AKT2	0.359089608351549
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1021	66/9376	1.11310954797732	JUN/HLA-DRB5/TLR4/STAT3/TNF/IL4R/STAT6/IL12RB2	0.322345547839814
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/1021	93/9376	1.0861794782682	ITPR2/ATP2B1/ATP1B1/LYZ/ADRB2/ATP2B4/VAMP2/PLCB2/ATP1A1/PRKACB/SLC4A2	0.291962075104817
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1021	86/9376	1.0678085780015	ATP1B1/CREB3L2/VAMP2/CREB1/PLCB2/ATP1A1/ATF6B/ATF4/PRKACB/CREB3L1	0.220826550134711
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1021	23/9376	1.19780266575821	MLH3/POLD3/MSH3	0.332005954790118
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/1021	59/9376	1.08952671857103	ENPP1/NT5C2/NME6/NT5C/TK2/ENTPD1/ENTPD4	0.241138140039941
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1021	32/9376	1.14789422135162	BIRC6/BCL2L1/BECN1/BIRC7	0.292944306423948
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1021	78/9376	1.05959466586303	JUN/TLR4/CD14/TNF/C4BPB/IRF3/IRAK1/MAPK14/ITGA5	0.184750321003718
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/1021	78/9376	1.05959466586303	JUN/CR1/HLA-DRB5/TLR4/JAK2/TNF/NCF4/IRAK1/MAPK14	0.184750321003718
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/1021	51/9376	1.08037103186034	ATP6V0A1/ATP6V0B/ATP6V0D1/PLCG2/PRKACB/SEC61A1	0.201180319756465
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1021	24/9376	1.14789422135162	HS2ST1/B3GAT3/GLCE	0.253588677685872
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	25/1021	226/9376	1.01583559411647	JUN/ATP2B1/PIK3R1/ROCK1/EP300/ATP1B1/ROCK2/MYL9/CREB3L2/ADRB2/ATP2B4/CREB1/ATP1A1/VAV1/BRAF/PRKACB/GRIN2C/CGA/PPARA/PIK3R3/RAF1/TIAM1/CREB3L1/AKT2/FXYD1	0.0842370824103965
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/1021	70/9376	1.04950328809291	HLA-DRB5/EIF4G3/CCND1/ABL2/CD55/LAMA2/DTNA/DAG1	0.145320480275273
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1021	99/9376	1.02035041897921	ITPR2/HRH1/PIK3R1/IGF1/PLCB2/PLCG2/PRKACB/PLA2G4C/PIK3R3/MAPK14/IL1R1	0.0711561523238385
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/1021	100/9376	1.01014691478942	IL6ST/CXCL14/IL10RA/IL2RA/TNF/CCL5/CSF1R/IL6R/LTBR/TNFRSF14/CCL13	0.0356598018381814
Cellular Processes	Cell motility	hsa04814	Motor proteins	21/1021	194/9376	0.99405272776841	TPM1/MYO1F/DYNC1H1/MYO5A/HOOK3/MYO9B/MYL9/KIF20B/DYNC1LI2/MYO7A/TPM2/MYO9A/DCTN5/KLC1/TNNT3/KIF2A/MYH10/MYO1C/KIF13B/MYO15B/DYNC2H1	-0.0292600673416068
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1021	17/9376	1.08037103186034	MTR/INMT	0.115940338318226
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/1021	56/9376	0.983909332587099	CR1/NAIP/CLK1/TLR4/CD14/TNF	-0.0422168084245814
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1021	94/9376	0.976931252214141	JUN/FOSB/IKBKB/TNF/ANAPC5/GSK3B/IL17RA/S100A8/MAPK14/TRAF5	-0.0785764579218713
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1021	37/9376	0.992773380628425	NANS/GPI/PGM3/UAP1L1	-0.0153961146804715
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1021	47/9376	0.976931252214141	PIK3R1/IKBKB/TNF/PIK3R3/INSR	-0.0554218074830923
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1021	76/9376	0.966647765348729	CD36/PLTP/PPARA/OLR1/RXRA/ACADM/NR1H3/SLC27A1	-0.102050595101765
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1021	76/9376	0.966647765348729	ITPR2/ATP1B1/PLCB2/ATP1A1/PRKACB/MYLK/HRH2/SLC4A2	-0.102050595101765
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/1021	133/9376	0.966647765348729	PIK3R1/SH3BP2/TNF/PPP3CA/NFATC2/VAV1/BRAF/PLCG2/SOS1/PIK3R3/PTPN11/RAF1/IFNAR2/PTK2B	-0.135415869828794
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1021	18/9376	1.02035041897921	ACSF3/CBR4	0.0302094883121614
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1021	28/9376	0.983909332587099	ATP6V0A1/ATP6V0D1/SLC12A7	-0.0298070505561379
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1021	115/9376	0.958242132606566	ITPR2/PIK3R1/GNG2/CREB3L2/JAK2/CREB1/PLCB2/ATF4/PRKACB/PIK3R3/CREB3L1/AKT2	-0.157501092647936
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1021	48/9376	0.956578517793014	TGOLN2/EGFR/SCARB1/CD9/DPP4	-0.105428074858181
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/1021	125/9376	0.955047992164545	PIK3R1/ROCK1/ROCK2/TNF/ORMDL1/PLCB2/DEGS1/PIK3R3/RAF1/MAPK14/PPP2R2A/AKT2/S1PR1	-0.176862208150118
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1021	39/9376	0.941861925211582	MTHFR/MAT2A/AHCYL1/MTR	-0.127178750103823
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/1021	88/9376	0.939186181105868	CR1/C7/SERPINE2/C4BPB/F13A1/PROS1/CD55/CLU/F3	-0.200358509054178
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/1021	79/9376	0.929939622360803	ATP6V0A1/ATP6V0B/SYT1/ATP6V0D1/DNM1/VAMP2/STX3/AP2A1	-0.218594830002887
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	20/1021	195/9376	0.941861925211582	CR1/PIK3R1/TLR4/TLR7/CLCN5/SELPLG/NCF4/ATG7/HDAC9/PLCB2/PLCG2/GSDMD/HDAC7/PIK3R3/RAF1/SLC25A4/MAPK14/HDAC8/TLR8/AKT2	-0.286786193975221
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1021	30/9376	0.918315377081293	OGDH/PDHB/IDH3B	-0.156643843144971
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1021	30/9376	0.918315377081293	PIGN/PIGM/DPM2	-0.156643843144971
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1021	20/9376	0.918315377081293	NANS/UAP1L1	-0.127830792665306
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1021	51/9376	0.900309193216954	ENPP2/PLA2G2A/PLA2G4C/PLPP3/PLA2G7	-0.249540511315606
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1021	41/9376	0.89591744105492	ATM/MRE11/BRCA2/POLD3	-0.233473723965944
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1021	31/9376	0.888692300401251	GPI/H6PD/PGD	-0.216990981107074
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1021	101/9376	0.909223145625042	EP300/CREB3L2/CREB1/PLCB2/GSK3B/PRKACB/TCF7L2/RAF1/WNT2/CREB3L1	-0.320629988352253
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1021	10/9376	0.918315377081293	SELENBP1	-0.0903417531160127
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1021	42/9376	0.874586073410755	HADHA/AOC1/DHTKD1/INMT	-0.284748729137764
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1021	63/9376	0.874586073410755	APC/GADD45B/POLK/GSK3B/TCF7L2/WNT2	-0.349137518457203
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/1021	85/9376	0.864296825488276	ENPP1/NT5C2/NME6/NT5C/TK2/ENTPD1/ENTPD4/AMPD3	-0.439332692647742
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1021	23/9376	0.798535110505472	ATP1B1/ATP1A1	-0.338152889582788
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/1021	97/9376	0.852045195230065	GNG2/PER3/KCNJ5/RYR1/CREB1/PLCB2/PRKACB/GRIN2C/PER1	-0.512023194880372
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1021	67/9376	0.822371979475785	ADPGK/ACSS1/LDHB/PDHB/GALM/GPI	-0.510061618219904
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1021	46/9376	0.798535110505472	PSMD7/PSMD1/PSMD13/PSME4	-0.478809486149665
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1021	36/9376	0.765262814234411	ENPP1/AGL/GPI	-0.493270323586927
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/1021	36/9376	0.765262814234411	GALNT6/B4GALT5/GALNT7	-0.493270323586927
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1021	36/9376	0.765262814234411	RNASEH2B/POLE/POLD3	-0.493270323586927
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1021	47/9376	0.781545001771313	ME2/ACSS1/LDHB/PDHB	-0.524829998053529
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/1021	69/9376	0.798535110505472	ITPR2/PPP3CA/ADRB2/CREB1/PLCB2/PRKACB	-0.587143612371795
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1021	90/9376	0.816280335183371	ATP1B1/EPHX1/ATP1A1/SCARB1/PRKACB/RXRA/SLC4A2/ABCG2	-0.612192270033048
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1021	59/9376	0.778233370407875	GPX3/GSTP1/GCLC/PGD/GSTM4	-0.597323273278985
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1021	26/9376	0.706396443908687	PLA2G2A/PLA2G4C	-0.524043649042326
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1021	49/9376	0.749645205780647	OGT/GALNT6/FUT11/GALNT7	-0.614197785402683
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1021	38/9376	0.724985824011547	JAK3/CIITA/DCLRE1C	-0.593806881672318
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1021	14/9376	0.655939555058066	B3GNT2	-0.450339175343258
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/1021	83/9376	0.774482848140849	FAR1/ABCD4/SOD2/PHYH/MLYCD/PEX26/PEX1	-0.721383056783172
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/1021	83/9376	0.774482848140849	MAVS/IKBKB/CCL5/IRF3/GSDMD/POLR2E/DDX41	-0.721383056783172
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/1021	298/9376	0.862846663029403	CSH1/IL6ST/TNFRSF25/CXCL14/PRLR/IL10RA/IL2RA/TNFRSF11A/TNF/CCL5/CSF1R/IL6R/LTBR/TNFRSF21/CSF2RA/CSH2/IL4R/IL12RB2/IL1RL1/TNFRSF14/IL17RA/EDA/CSF3R/BMP5/IFNAR2/CCL13/IL1R1/LTB	-0.841094326514218
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1021	28/9376	0.655939555058066	B3GNT2/ST3GAL6	-0.637352498413417
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/1021	116/9376	0.791651187139046	ADPGK/ME2/ACSS1/OGDH/PDHB/IDH3B/GPI/H6PD/ACADS/PGD	-0.789295839647162
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/1021	116/9376	0.791651187139046	ITPR2/GNG2/PPP3CA/SLC38A2/GRK3/PLCB2/PRKACB/HOMER1/GRIN2C/PLA2G4C	-0.789295839647162
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1021	29/9376	0.633320949711236	LIMD1/STK3	-0.691312257894948
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1021	16/9376	0.573947110675808	GLA	-0.596225935880077
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	30/1021	323/9376	0.852924498837114	ZEB2/TPM1/ATM/MDM4/PIK3R1/ROCK1/VIM/DICER1/APC/EP300/CCND1/IKBKB/STAT3/TIMP3/DNMT3A/FOXP1/TNXB/DNMT1/PLCG2/CCND2/CDK6/EGFR/E2F3/SOS1/PIK3R3/RAF1/SOX4/PDGFRA/NOTCH1/ITGA5	-0.940309058757471
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1021	30/9376	0.612210251387528	PLA2G2A/PLA2G4C	-0.743651306505181
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1021	54/9376	0.680233612652809	REV1/POLK/REV3L/BRCA2	-0.823759475346849
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1021	17/9376	0.540185515930172	CSAD	-0.663311713346065
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1021	17/9376	0.540185515930172	CA8	-0.663311713346065
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/1021	43/9376	0.640685146800902	HADHA/ACADS/ACADM	-0.825513247915165
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1021	44/9376	0.626124120737245	HLA-DRB5/TNF/ICA1	-0.868943827755295
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/1021	56/9376	0.655939555058066	MAN1A1/MAN1A2/DPM2/ALG5	-0.902705494922135
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1021	32/9376	0.573947110675808	GALM/GLA	-0.843912405923295
Human Diseases	Immune disease	hsa05310	Asthma	2/1021	32/9376	0.573947110675808	HLA-DRB5/TNF	-0.843912405923295
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/1021	102/9376	0.720247354573563	ITPR2/ATP2B1/ATP1B1/PLA2G2A/ATP2B4/PLCB2/ATP1A1/SLC4A2	-0.993038357997528
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/1021	157/9376	0.760388528793427	APC/CCND1/CSNK1D/LIMD1/GSK3B/DLG1/CCND2/TCF7L2/BMP5/WNT2/STK3/PPP2R2A/AREG	-1.05837800672356
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/1021	168/9376	0.765262814234411	CFLAR/TLR4/JAK2/STAT3/TNF/STAT6/CYLD/DNM1L/TRPM7/JAK3/PLA2G4C/IFNAR2/SLC25A4/TRAF5	-1.07319628652687
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1021	19/9376	0.483323882674365	HGSNAT	-0.788047063720534
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/1021	138/9376	0.731990517963349	ITPR2/CPEB4/IGF1/PPP3CA/SMC3/ANAPC5/CDC27/PRKACB/MAPK14/IGF1R/ANAPC7	-1.10873052837574
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1021	35/9376	0.524751644046453	ENOSF1/PFKFB2	-0.984653074820388
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1021	50/9376	0.550989226248776	HLA-DRB5/LTBR/MAP3K14	-1.11280569738764
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1021	22/9376	0.417416080491497	AOC1	-0.956305013948053
NA	NA	hsa04081	Hormone signaling	18/1021	219/9376	0.754779761984624	CSH1/SLC40A1/PIK3R1/PRLR/GNG2/IGF1/JAK2/STAT3/ADRB2/CSH2/ITGAV/PLCB2/SMAD5/PRKACB/CGA/PIK3R3/INSR/IGF1R	-1.28359211939934
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1021	37/9376	0.496386690314212	RIMKLB/ABAT	-1.072934365553
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1021	23/9376	0.399267555252736	LARGE1	-1.00831173395569
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1021	23/9376	0.399267555252736	LNPEP	-1.00831173395569
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1021	191/9376	0.721190086713057	FOSB/GNG2/CREB3L2/CREB1/HDAC9/ATF6B/ATF4/BRAF/PRKACB/GRIN2C/SOS1/HDAC7/RAF1/HDAC8/CREB3L1	-1.36085106272109
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1021	39/9376	0.470930962605791	HLA-DRB5/TNF	-1.15735409435733
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/1021	160/9376	0.68873653281097	HLA-DRB5/LRRC4/VCAN/SELPLG/GLG1/ITGAV/ITGA6/PTPRM/CADM3/CD276/SLITRK4/SDC2	-1.38816851896639
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/1021	115/9376	0.638828088404378	ITPR2/GNG2/KCNJ5/PLCB2/BRAF/PRKACB/PLA2G4C/RAF1	-1.36225756392434
NA	NA	hsa04382	Cornified envelope formation	17/1021	217/9376	0.719417576515298	S100A6/COL4A2/COL4A1/S100A10/S100A4/S100A1/ITGA6/KRT18/UGCG/KRT7/PLEC/DST/S100A8/S100A13/PPP2R2A/KRT8/SLC27A1	-1.46181219829445
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/1021	82/9376	0.559948400659325	GSTP1/CES2/NME6/TK2/GSTM4	-1.39905400159785
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/1021	82/9376	0.559948400659325	HLA-DRB5/TNF/CREB1/CIITA/HSPA2	-1.39905400159785
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/1021	154/9376	0.655939555058066	BCAT1/MAT2A/PANK3/COQ7/QPRT/NME6/UROS/GCLC/NAPRT/COQ4/VKORC1L1	-1.50490065161591
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/1021	44/9376	0.417416080491497	MAN1A1/MAN1A2	-1.35401273279421
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1021	45/9376	0.408140167591686	HLA-DRB5/TNF	-1.3911895639302
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/1021	75/9376	0.489768201110023	BCAT1/MAT2A/MTR/IDH3B	-1.55081007236319
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1021	31/9376	0.296230766800417	ACSS1	-1.37197675394836
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/1021	63/9376	0.437293036705378	PTGDS/PLA2G2A/PLA2G4C	-1.56650954265011
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/1021	128/9376	0.573947110675808	ENPP1/NT5C2/NME6/NT5C/ENTPD1/ENPP4/ENTPD4/AMPD3	-1.69656253104201
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/1021	50/9376	0.367326150832517	AMD1/AOC1	-1.56798701746034
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1021	54/9376	0.340116806326405	HLA-DRB5/CGA	-1.69994425593131
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1021	70/9376	0.39356373303484	EPHX1/GSTP1/GSTM4	-1.78023749465542
Genetic Information Processing	Translation	hsa03010	Ribosome	15/1021	222/9376	0.620483362892766	RPL13A/RPS20/RPL7/RPS11/RPS26/RPL31/RPL23/MRPS5/RPS14/RPLP2/RPS8/MRPS34/RPL27A/DAP3/MRPL55	-2.00044739041943
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/1021	89/9376	0.412726012171368	GNG2/SLC38A2/PRKACB/ABAT	-1.94591258891282
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1021	41/9376	0.22397936026373	GRIN2C	-1.74073764586497
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/1021	91/9376	0.403655110804964	GNG2/KCNJ5/GRK3/PRKACB	-1.99826244252288
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/1021	79/9376	0.348727358385301	EPHX1/GSTP1/GSTM4	-2.03203061668407
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1021	46/9376	0.199633777626368	UROS	-1.90218226425342
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1021	66/9376	0.278277386994331	HSD17B12/HSD17B2	-2.05680311908181
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/1021	99/9376	0.371036515992442	HLA-DRB5/SELPLG/KRT18/FCAR	-2.19919901992612
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	10/1021	183/9376	0.501811681465187	CSNK2A1/FBL/UTP14C/NXF1/MPHOSPH10/LSG1/RBM28/WDR36/MDN1/NOP58	-2.37911665328321
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1021	86/9376	0.320342573400451	SCN9A/PLCB2/PRKACB	-2.21338375192127
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/1021	73/9376	0.251593253994875	GSTP1/GSTM4	-2.24394855082358
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1021	143/9376	0.321089292685767	HLA-DRB5/C7/TNF/ACTN4/ACTN1	-2.85979262080518
NA	NA	hsa04082	Neuroactive ligand signaling	8/1021	199/9376	0.369172010886952	HRH1/GNG2/ADRB2/PLCB2/P2RY13/PRKACB/GRIN2C/HRH2	-3.14421625589061
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/1021	370/9376	0.372290017735659	CSH1/HRH1/PRLR/ADRB2/NR3C1/CSH2/CYSLTR1/P2RY13/P2RX7/GRIN2C/CGA/HRH2/SPX/S1PR1/LTB4R	-4.30644800477582
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1021	449/9376	0.040904916573777	GRK3/PRKACB	-7.28043535382463