ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 115/2103 495/18639 0.232323232323232 2.05909307050534 1.74365929351199e-14 2.15865020536784e-11 GO:0030695 GTPase regulator activity 101/2103 489/18639 0.206543967280164 1.83061008375415 9.30788382726536e-10 4.31444487590379e-07 GO:0060589 nucleoside-triphosphatase regulator activity 101/2103 490/18639 0.206122448979592 1.82687414480771 1.04550360482321e-09 4.31444487590379e-07 GO:0042393 histone binding 60/2103 247/18639 0.242914979757085 2.15296828706244 5.70961171192274e-09 1.76712482484009e-06 GO:0003713 transcription coactivator activity 59/2103 256/18639 0.23046875 2.04265669579173 5.81871570721949e-08 1.44071400910755e-05 GO:0051020 GTPase binding 67/2103 315/18639 0.212698412698413 1.88515725833843 2.00331472387143e-07 4.13350604692138e-05 GO:0061775 cohesin loader activity 40/2103 153/18639 0.261437908496732 2.31713798215435 2.44121277748914e-07 4.31745916933079e-05 GO:0016887 ATP hydrolysis activity 82/2103 417/18639 0.196642685851319 1.74285450384343 3.20341466385845e-07 4.36809575442629e-05 GO:0140033 acetylation-dependent protein binding 13/2103 24/18639 0.541666666666667 4.80082025677603 3.46982325230738e-07 4.36809575442629e-05 GO:0004386 helicase activity 40/2103 155/18639 0.258064516129032 2.2872394275459 3.54003877948996e-07 4.36809575442629e-05 GO:0031267 small GTPase binding 61/2103 283/18639 0.215547703180212 1.91041067026913 4.30518181244955e-07 4.36809575442629e-05 GO:0005096 GTPase activator activity 59/2103 271/18639 0.217712177121771 1.92959451705787 4.65432637810454e-07 4.36809575442629e-05 GO:0016755 aminoacyltransferase activity 93/2103 496/18639 0.1875 1.66182239657632 5.06297182126516e-07 4.36809575442629e-05 GO:0008094 ATP-dependent activity, acting on DNA 49/2103 210/18639 0.233333333333333 2.06804564907275 5.0915952896542e-07 4.36809575442629e-05 GO:0140097 catalytic activity, acting on DNA 69/2103 336/18639 0.205357142857143 1.82009119625025 5.29252312733395e-07 4.36809575442629e-05 GO:0140658 ATP-dependent chromatin remodeler activity 40/2103 158/18639 0.253164556962025 2.24381083082035 6.08040281348106e-07 4.70471167693097e-05 GO:0019787 ubiquitin-like protein transferase activity 90/2103 479/18639 0.187891440501044 1.66529175439798 7.02679760487598e-07 5.11716202049204e-05 GO:0000510 H3-H4 histone complex chaperone activity 38/2103 151/18639 0.251655629139073 2.23043712388168 1.34824753538756e-06 7.72420528771512e-05 GO:0140584 chromatin extrusion motor activity 38/2103 151/18639 0.251655629139073 2.23043712388168 1.34824753538756e-06 7.72420528771512e-05 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 38/2103 151/18639 0.251655629139073 2.23043712388168 1.34824753538756e-06 7.72420528771512e-05 GO:0140849 ATP-dependent H2AZ histone chaperone activity 38/2103 151/18639 0.251655629139073 2.23043712388168 1.34824753538756e-06 7.72420528771512e-05 GO:0140104 molecular carrier activity 54/2103 249/18639 0.216867469879518 1.92210783218466 1.59215671020762e-06 7.72420528771512e-05 GO:0140297 DNA-binding transcription factor binding 90/2103 488/18639 0.184426229508197 1.63457940646851 1.59521630335714e-06 7.72420528771512e-05 GO:0015616 DNA translocase activity 38/2103 152/18639 0.25 2.21576319543509 1.60466138290755e-06 7.72420528771512e-05 GO:0140674 ATP-dependent histone chaperone activity 38/2103 152/18639 0.25 2.21576319543509 1.60466138290755e-06 7.72420528771512e-05 GO:0070577 lysine-acetylated histone binding 12/2103 23/18639 0.521739130434783 4.6242014513428 1.68709426864526e-06 7.72420528771512e-05 GO:0140713 histone chaperone activity 40/2103 164/18639 0.24390243902439 2.16172019066838 1.69554363517176e-06 7.72420528771512e-05 GO:0140597 protein carrier chaperone 44/2103 188/18639 0.234042553191489 2.07433150210945 1.74699311838468e-06 7.72420528771512e-05 GO:0061659 ubiquitin-like protein ligase activity 72/2103 372/18639 0.193548387096774 1.71542957065943 3.00496757383602e-06 0.000128281029531345 GO:0019838 growth factor binding 34/2103 136/18639 0.25 2.21576319543509 5.56056145294978e-06 0.000229465835958394 GO:0003689 DNA clamp loader activity 38/2103 160/18639 0.2375 2.10497503566334 5.99329283648339e-06 0.000239345049405369 GO:0140938 histone H3 methyltransferase activity 17/2103 47/18639 0.361702127659574 3.2057850487146 7.16413208099869e-06 0.000268763500493223 GO:1990518 single-stranded 3'-5' DNA helicase activity 17/2103 47/18639 0.361702127659574 3.2057850487146 7.16413208099869e-06 0.000268763500493223 GO:0005201 extracellular matrix structural constituent 39/2103 168/18639 0.232142857142857 2.05749439576116 8.12614655317917e-06 0.000295887336259877 GO:0043138 3'-5' DNA helicase activity 17/2103 48/18639 0.354166666666667 3.13899786019971 9.93284970728991e-06 0.00035133908393214 GO:0031490 chromatin DNA binding 32/2103 128/18639 0.25 2.21576319543509 1.0364033036694e-05 0.000356407580539642 GO:0140296 general transcription initiation factor binding 18/2103 53/18639 0.339622641509434 3.0100933975722 1.07435091609672e-05 0.000359472009223714 GO:0004842 ubiquitin-protein transferase activity 81/2103 449/18639 0.180400890868597 1.59890261764136 1.22261722235989e-05 0.00039831582138988 GO:0141003 histone H2AX kinase activity 67/2103 354/18639 0.189265536723164 1.67747044174182 1.40711269129137e-05 0.000446668079953517 GO:0070063 RNA polymerase binding 19/2103 59/18639 0.322033898305085 2.85420343818758 1.47472248967685e-05 0.000456426610554984 GO:0005085 guanyl-nucleotide exchange factor activity 48/2103 230/18639 0.208695652173913 1.84968058053712 1.74240183292118e-05 0.000526120358330834 GO:0140996 histone H3 kinase activity 67/2103 357/18639 0.187675070028011 1.66337405147508 1.86646904223848e-05 0.000543484010212342 GO:0001098 basal transcription machinery binding 19/2103 60/18639 0.316666666666667 2.80663338088445 1.93160714453498e-05 0.000543484010212342 GO:0001099 basal RNA polymerase II transcription machinery binding 19/2103 60/18639 0.316666666666667 2.80663338088445 1.93160714453498e-05 0.000543484010212342 GO:0035173 histone kinase activity 67/2103 360/18639 0.186111111111111 1.64951260104612 2.46158142115937e-05 0.000677208399865623 GO:0019902 phosphatase binding 41/2103 190/18639 0.215789473684211 1.91255349500713 3.09711629590691e-05 0.000804174498109609 GO:0042054 histone methyltransferase activity 20/2103 67/18639 0.298507462686567 2.64568739753444 3.10393479887136e-05 0.000804174498109609 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 65/2103 349/18639 0.186246418338109 1.65071183614076 3.1579118997133e-05 0.000804174498109609 GO:0061749 forked DNA-dependent helicase activity 16/2103 47/18639 0.340425531914894 3.01720945761374 3.18292006521574e-05 0.000804174498109609 GO:0003714 transcription corepressor activity 43/2103 204/18639 0.21078431372549 1.86819249811194 3.64052843024377e-05 0.000901394839328358 GO:0009378 four-way junction helicase activity 16/2103 48/18639 0.333333333333333 2.95435092724679 4.27773761245908e-05 0.0010053532685513 GO:0036121 double-stranded DNA helicase activity 16/2103 48/18639 0.333333333333333 2.95435092724679 4.27773761245908e-05 0.0010053532685513 GO:0061980 regulatory RNA binding 18/2103 58/18639 0.310344827586207 2.75060258743667 4.30401641625357e-05 0.0010053532685513 GO:0016922 nuclear receptor binding 32/2103 137/18639 0.233576642335766 2.07020210960359 4.47537661053708e-05 0.00102602152663795 GO:0048407 platelet-derived growth factor binding 7/2103 11/18639 0.636363636363636 5.64012449747115 5.03566519562704e-05 0.00113348245676114 GO:0003725 double-stranded RNA binding 21/2103 75/18639 0.28 2.4816547788873 5.70226319971892e-05 0.00126060747165215 GO:0001221 transcription coregulator binding 28/2103 115/18639 0.243478260869565 2.15796067729331 6.00902996588899e-05 0.00130511913995975 GO:0061630 ubiquitin protein ligase activity 64/2103 353/18639 0.181303116147309 1.6068990879076 8.29689501196176e-05 0.00177095793531184 GO:0140030 modification-dependent protein binding 37/2103 173/18639 0.213872832369942 1.89556620187511 8.97597510994231e-05 0.00188343342137434 GO:0022853 active monoatomic ion transmembrane transporter activity 28/2103 118/18639 0.23728813559322 2.10309727024348 9.75077133664118e-05 0.0020119091524603 GO:0008276 protein methyltransferase activity 24/2103 95/18639 0.252631578947368 2.23908701854494 0.00010628309105494 0.00215702404468878 GO:0019789 SUMO transferase activity 11/2103 28/18639 0.392857142857143 3.48191359282657 0.000126434286203202 0.00252460719870264 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 19/2103 68/18639 0.279411764705882 2.47644121842746 0.000130631377594458 0.00256701024542761 GO:0003678 DNA helicase activity 20/2103 74/18639 0.27027027027027 2.39541967074064 0.000145171026105974 0.00280815203623744 GO:0017116 single-stranded DNA helicase activity 17/2103 58/18639 0.293103448275862 2.59779133257907 0.000153682540527032 0.00292706131034563 GO:0016279 protein-lysine N-methyltransferase activity 19/2103 69/18639 0.27536231884058 2.44055076598648 0.00016142483431179 0.00302793855875752 GO:0010484 histone H3 acetyltransferase activity 11/2103 29/18639 0.379310344827586 3.36184760686704 0.0001830359730542 0.00338206768121044 GO:0016278 lysine N-methyltransferase activity 19/2103 70/18639 0.271428571428571 2.40568575504381 0.000198411122541269 0.00361224955450133 GO:0140857 histone H3T45 kinase activity 47/2103 246/18639 0.191056910569106 1.69334748269023 0.000202554025786151 0.00363423020178631 GO:0140463 chromatin-protein adaptor activity 16/2103 54/18639 0.296296296296296 2.62608971310826 0.000207329947243316 0.00366677820981751 GO:0031994 insulin-like growth factor I binding 7/2103 13/18639 0.538461538461538 4.77241303632174 0.000213206504987779 0.00370546624840801 GO:0042974 nuclear retinoic acid receptor binding 10/2103 25/18639 0.4 3.54522111269615 0.000215503691345216 0.00370546624840801 GO:0004679 AMP-activated protein kinase activity 47/2103 248/18639 0.189516129032258 1.67969145460402 0.000245986470003755 0.00417166095704998 GO:0106310 protein serine kinase activity 63/2103 361/18639 0.174515235457064 1.5467377430738 0.000282519282348375 0.0042413621357721 GO:0010485 histone H4 acetyltransferase activity 12/2103 35/18639 0.342857142857143 3.03876095373956 0.000284872634428001 0.0042413621357721 GO:0004674 protein serine/threonine kinase activity 73/2103 433/18639 0.168591224018476 1.49423291701397 0.00028697737540677 0.0042413621357721 GO:0015631 tubulin binding 66/2103 385/18639 0.171428571428571 1.51938047686978 0.000343077390929803 0.0042413621357721 GO:0004676 3-phosphoinositide-dependent protein kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0004711 ribosomal protein S6 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0035175 histone H3S10 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0035979 histone H2AXS139 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0044022 histone H3S28 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0044023 histone H4S1 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0044024 histone H2AS1 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0044025 histone H2BS14 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0072354 histone H3T3 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0072371 histone H2AS121 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0072518 Rho-dependent protein serine/threonine kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0140823 histone H2BS36 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0140855 histone H3S57 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0140995 histone H2A kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0140997 histone H4 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0140998 histone H2B kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:1990244 histone H2AT120 kinase activity 46/2103 245/18639 0.187755102040816 1.6640833794288 0.000353517798656478 0.0042413621357721 GO:0032931 histone H3K56 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0043992 histone H3K9 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0043993 histone H3K18 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0043994 histone H3K23 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0043999 histone H2AK5 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0044012 histone H2AK9 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0044014 histone H2BK5 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0044015 histone H2BK12 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0044016 histone H3K4 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0044017 histone H3K27 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0044018 histone H3K36 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0050321 tau-protein kinase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0140908 histone H3K122 acetyltransferase activity 9/2103 22/18639 0.409090909090909 3.62579431980288 0.000366579764561886 0.0042413621357721 GO:0046332 SMAD binding 20/2103 79/18639 0.253164556962025 2.24381083082035 0.000376030282712435 0.00429143267342692 GO:0000993 RNA polymerase II complex binding 12/2103 36/18639 0.333333333333333 2.95435092724679 0.000383805685669163 0.00429143267342692 GO:0061665 SUMO ligase activity 7/2103 14/18639 0.5 4.43152639087019 0.00038488540799269 0.00429143267342692 GO:0008137 NADH dehydrogenase (ubiquinone) activity 13/2103 41/18639 0.317073170731707 2.8102362478689 0.000386386773787975 0.00429143267342692 GO:0004677 DNA-dependent protein kinase activity 46/2103 246/18639 0.186991869918699 1.65731881284576 0.000388239466416652 0.00429143267342692 GO:0015399 primary active transmembrane transporter activity 34/2103 166/18639 0.204819277108434 1.81532406372996 0.000398343588177654 0.00436415364746846 GO:0035402 histone H3T11 kinase activity 46/2103 247/18639 0.186234817813765 1.6506090200812 0.000425982150396427 0.00458579045383284 GO:0035403 histone H3T6 kinase activity 46/2103 247/18639 0.186234817813765 1.6506090200812 0.000425982150396427 0.00458579045383284 GO:0005516 calmodulin binding 40/2103 207/18639 0.193236714975845 1.71266720420104 0.000458075421896107 0.0048887704509257 GO:0008170 N-methyltransferase activity 23/2103 98/18639 0.23469387755102 2.08010422428601 0.000466185951174235 0.00493280519276669 GO:0035198 miRNA binding 13/2103 42/18639 0.30952380952381 2.74332586101488 0.000502388639511481 0.00522653055222869 GO:0043175 RNA polymerase core enzyme binding 13/2103 42/18639 0.30952380952381 2.74332586101488 0.000502388639511481 0.00522653055222869 GO:0044013 histone H2B acetyltransferase activity 9/2103 23/18639 0.391304347826087 3.4681510885071 0.000542274974755845 0.00559447015623113 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 45/2103 243/18639 0.185185185185185 1.64130607069266 0.000554245625810979 0.00567071144424787 GO:0003779 actin binding 73/2103 443/18639 0.164785553047404 1.46050305432742 0.000566066147991827 0.00574417943617936 GO:0097493 structural molecule activity conferring elasticity 6/2103 11/18639 0.545454545454545 4.83439242640384 0.000571671331346561 0.00575389518867514 GO:0140693 molecular condensate scaffold activity 14/2103 48/18639 0.291666666666667 2.58505706134094 0.000607345884260615 0.00606366294124711 GO:0042800 histone H3K4 methyltransferase activity 8/2103 19/18639 0.421052631578947 3.73181169757489 0.000621282086416296 0.00611832229728979 GO:0036408 histone H3K14 acetyltransferase activity 10/2103 28/18639 0.357142857142857 3.1653759934787 0.00062973767558873 0.00611832229728979 GO:0046966 nuclear thyroid hormone receptor binding 10/2103 28/18639 0.357142857142857 3.1653759934787 0.00062973767558873 0.00611832229728979 GO:0019903 protein phosphatase binding 30/2103 144/18639 0.208333333333333 1.84646932952924 0.000632589058201206 0.00611832229728979 GO:0048156 tau protein binding 13/2103 43/18639 0.302325581395349 2.67952758517732 0.00064653984220531 0.00620477771046646 GO:0043021 ribonucleoprotein complex binding 35/2103 177/18639 0.19774011299435 1.75258105853623 0.00065252058293517 0.00621400370518262 GO:0043998 histone H2A acetyltransferase activity 9/2103 24/18639 0.375 3.32364479315264 0.0007813712147106 0.00738425621230323 GO:0003954 NADH dehydrogenase activity 13/2103 44/18639 0.295454545454545 2.61862923096875 0.000824018990203778 0.00772829931721422 GO:0004713 protein tyrosine kinase activity 29/2103 140/18639 0.207142857142857 1.83591807621765 0.000849823853875553 0.00791039045938297 GO:1990247 N6-methyladenosine-containing RNA reader activity 6/2103 12/18639 0.5 4.43152639087019 0.00103430032882353 0.00952177268349863 GO:0009055 electron transfer activity 25/2103 116/18639 0.21551724137931 1.91014068571991 0.0010383193152442 0.00952177268349863 GO:0004709 MAP kinase kinase kinase activity 9/2103 25/18639 0.36 3.19069900142653 0.00109967169660363 0.0100102467676124 GO:0140566 histone reader activity 11/2103 35/18639 0.314285714285714 2.78553087426126 0.00116467688169883 0.0103232179482986 GO:0043995 histone H4K5 acetyltransferase activity 10/2103 30/18639 0.333333333333333 2.95435092724679 0.00116740752242472 0.0103232179482986 GO:0043996 histone H4K8 acetyltransferase activity 10/2103 30/18639 0.333333333333333 2.95435092724679 0.00116740752242472 0.0103232179482986 GO:0043997 histone H4K12 acetyltransferase activity 10/2103 30/18639 0.333333333333333 2.95435092724679 0.00116740752242472 0.0103232179482986 GO:0050681 nuclear androgen receptor binding 9/2103 26/18639 0.346153846153846 3.06797980906397 0.00151510252040425 0.0133028150373082 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 15/2103 58/18639 0.258620689655172 2.29216882286389 0.00154803437389161 0.01349624334421 GO:0061733 protein-lysine-acetyltransferase activity 13/2103 47/18639 0.276595744680851 2.45148268431117 0.00161762567189522 0.014004339732911 GO:0046975 histone H3K36 methyltransferase activity 6/2103 13/18639 0.461538461538462 4.09063974541863 0.00173809503496845 0.0148397355399375 GO:0051011 microtubule minus-end binding 6/2103 13/18639 0.461538461538462 4.09063974541863 0.00173809503496845 0.0148397355399375 GO:0034212 protein N-acetyltransferase activity 14/2103 53/18639 0.264150943396226 2.34118375366727 0.00176415284572664 0.0148572872313577 GO:0051018 protein kinase A binding 14/2103 53/18639 0.264150943396226 2.34118375366727 0.00176415284572664 0.0148572872313577 GO:0004402 histone acetyltransferase activity 12/2103 42/18639 0.285714285714286 2.53230079478296 0.00178444503190608 0.0149266415506738 GO:0003727 single-stranded RNA binding 20/2103 89/18639 0.224719101123595 1.99169725432368 0.00186958329369717 0.0155338531382356 GO:0046972 histone H4K16 acetyltransferase activity 8/2103 22/18639 0.363636363636364 3.22292828426923 0.00192787700951697 0.0159114115852134 GO:0043014 alpha-tubulin binding 12/2103 44/18639 0.272727272727273 2.41719621320192 0.00275026401141744 0.022548522159833 GO:0005381 iron ion transmembrane transporter activity 5/2103 10/18639 0.5 4.43152639087019 0.00281220854384354 0.022754994622734 GO:0045322 unmethylated CpG binding 5/2103 10/18639 0.5 4.43152639087019 0.00281220854384354 0.022754994622734 GO:0046915 transition metal ion transmembrane transporter activity 12/2103 45/18639 0.266666666666667 2.36348074179743 0.00337195112828875 0.0269518210257004 GO:0005520 insulin-like growth factor binding 7/2103 19/18639 0.368421052631579 3.26533523537803 0.0033961906946763 0.0269518210257004 GO:1990380 K48-linked deubiquitinase activity 7/2103 19/18639 0.368421052631579 3.26533523537803 0.0033961906946763 0.0269518210257004 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 31/2103 167/18639 0.18562874251497 1.64523734271827 0.00358824909540395 0.0281050256603434 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/2103 24/18639 0.333333333333333 2.95435092724679 0.00360961153472907 0.0281050256603434 GO:0035035 histone acetyltransferase binding 8/2103 24/18639 0.333333333333333 2.95435092724679 0.00360961153472907 0.0281050256603434 GO:0045296 cadherin binding 54/2103 334/18639 0.161676646706587 1.43294865333527 0.0041516072052253 0.0321230607504307 GO:0008168 methyltransferase activity 36/2103 204/18639 0.176470588235294 1.56406813795418 0.00431668425485082 0.0331928888664927 GO:0008017 microtubule binding 46/2103 276/18639 0.166666666666667 1.4771754636234 0.00437132260777103 0.0334055394346947 GO:0001968 fibronectin binding 9/2103 30/18639 0.3 2.65891583452211 0.00457656420445637 0.034619975898545 GO:0035091 phosphatidylinositol binding 47/2103 284/18639 0.165492957746479 1.46677281951337 0.00458616805118043 0.034619975898545 GO:0008172 S-methyltransferase activity 5/2103 11/18639 0.454545454545455 4.02866035533653 0.00467932288759104 0.0351091014232588 GO:0003724 RNA helicase activity 17/2103 77/18639 0.220779220779221 1.95677788687774 0.00479564024642146 0.0357650760546371 GO:0004879 nuclear receptor activity 14/2103 59/18639 0.23728813559322 2.10309727024348 0.00512153674963721 0.0379668412937177 GO:0015078 proton transmembrane transporter activity 33/2103 185/18639 0.178378378378378 1.58097698268882 0.005157099902999 0.0380029147613855 GO:0005543 phospholipid binding 75/2103 497/18639 0.150905432595573 1.33748281414593 0.00529187485712357 0.0387653317936034 GO:0098531 ligand-modulated transcription factor activity 14/2103 60/18639 0.233333333333333 2.06804564907275 0.00600180096651725 0.0437072329208727 GO:0008186 ATP-dependent activity, acting on RNA 17/2103 79/18639 0.215189873417722 1.9072392061973 0.00629117355617386 0.0455466249271534 GO:0043022 ribosome binding 22/2103 112/18639 0.196428571428571 1.74095679641329 0.00657327091658774 0.0473122639228815 GO:0051219 phosphoprotein binding 19/2103 93/18639 0.204301075268817 1.81073121347384 0.00721943166779892 0.051521389210314 GO:0034452 dynactin binding 5/2103 12/18639 0.416666666666667 3.69293865905849 0.00728291042956781 0.051521389210314 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/2103 12/18639 0.416666666666667 3.69293865905849 0.00728291042956781 0.051521389210314 GO:0019783 ubiquitin-like protein peptidase activity 24/2103 127/18639 0.188976377952756 1.67490761229739 0.00767367241554408 0.0539773093775203 GO:0042162 telomeric DNA binding 10/2103 38/18639 0.263157894736842 2.33238231098431 0.00794139519853239 0.055544899750187 GO:0001618 virus receptor activity 17/2103 81/18639 0.209876543209877 1.86014688011835 0.00814366574025187 0.056639652732763 GO:0001223 transcription coactivator binding 11/2103 44/18639 0.25 2.21576319543509 0.00827620662051013 0.0569219099788419 GO:0030020 extracellular matrix structural constituent conferring tensile strength 11/2103 44/18639 0.25 2.21576319543509 0.00827620662051013 0.0569219099788419 GO:0015278 intracellularly gated calcium channel activity 6/2103 17/18639 0.352941176470588 3.12813627590837 0.00842596066129353 0.0570018540911551 GO:0032183 SUMO binding 6/2103 17/18639 0.352941176470588 3.12813627590837 0.00842596066129353 0.0570018540911551 GO:0048038 quinone binding 6/2103 17/18639 0.352941176470588 3.12813627590837 0.00842596066129353 0.0570018540911551 GO:0140517 protein-RNA adaptor activity 7/2103 22/18639 0.318181818181818 2.82006224873557 0.00849168186477092 0.0571342508075348 GO:0019207 kinase regulator activity 46/2103 287/18639 0.160278745644599 1.42055898243922 0.0089887046953531 0.0600023772736222 GO:0008080 N-acetyltransferase activity 15/2103 69/18639 0.217391304347826 1.92675060472617 0.00901489674708703 0.0600023772736222 GO:0140272 exogenous protein binding 17/2103 82/18639 0.207317073170732 1.83746216206813 0.00922134960739251 0.0610482931227376 GO:0004715 non-membrane spanning protein tyrosine kinase activity 11/2103 45/18639 0.244444444444444 2.16652401331431 0.00986287751505236 0.0649480976789086 GO:0016741 transferase activity, transferring one-carbon groups 36/2103 215/18639 0.167441860465116 1.48404604717513 0.00999754781044719 0.0654865830123472 GO:0141052 histone H3 demethylase activity 8/2103 28/18639 0.285714285714286 2.53230079478296 0.0101326955945705 0.0659641957071451 GO:0016407 acetyltransferase activity 19/2103 96/18639 0.197916666666667 1.75414586305278 0.0101770285784045 0.0659641957071451 GO:0097110 scaffold protein binding 15/2103 70/18639 0.214285714285714 1.89922559608722 0.0103074908622133 0.0664618421219794 GO:0046974 histone H3K9 methyltransferase activity 5/2103 13/18639 0.384615384615385 3.40886645451553 0.0107484200511924 0.0689458239553173 GO:0003887 DNA-directed DNA polymerase activity 7/2103 23/18639 0.304347826086957 2.69745084661663 0.0110400393475003 0.0700900959600275 GO:0005158 insulin receptor binding 7/2103 23/18639 0.304347826086957 2.69745084661663 0.0110400393475003 0.0700900959600275 GO:0000900 mRNA regulatory element binding translation repressor activity 6/2103 18/18639 0.333333333333333 2.95435092724679 0.0114520130198079 0.0716040005985971 GO:0004706 JUN kinase kinase kinase activity 6/2103 18/18639 0.333333333333333 2.95435092724679 0.0114520130198079 0.0716040005985971 GO:0070064 proline-rich region binding 6/2103 18/18639 0.333333333333333 2.95435092724679 0.0114520130198079 0.0716040005985971 GO:0038024 cargo receptor activity 14/2103 65/18639 0.215384615384615 1.9089652145287 0.012374015630964 0.0769800570408715 GO:0045309 protein phosphorylated amino acid binding 13/2103 59/18639 0.220338983050847 1.95287603665466 0.0129470435197957 0.0801421993875355 GO:0005518 collagen binding 15/2103 72/18639 0.208333333333333 1.84646932952924 0.0133269649774767 0.0820834957319214 GO:0001784 phosphotyrosine residue binding 11/2103 47/18639 0.234042553191489 2.07433150210945 0.0137264683573996 0.0840821009387996 GO:0001727 lipid kinase activity 10/2103 41/18639 0.24390243902439 2.16172019066838 0.0137872911878645 0.0840821009387996 GO:0070840 dynein complex binding 7/2103 24/18639 0.291666666666667 2.58505706134094 0.0140996272704061 0.0855653851017781 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 13/2103 60/18639 0.216666666666667 1.92032810271041 0.014868068055809 0.0897886256248365 GO:0005545 1-phosphatidylinositol binding 5/2103 14/18639 0.357142857142857 3.1653759934787 0.0151903188267436 0.0912893917840223 GO:0031624 ubiquitin conjugating enzyme binding 8/2103 30/18639 0.266666666666667 2.36348074179743 0.0155707061752477 0.0926756454084455 GO:0032452 histone demethylase activity 8/2103 30/18639 0.266666666666667 2.36348074179743 0.0155707061752477 0.0926756454084455 GO:0050840 extracellular matrix binding 14/2103 67/18639 0.208955223880597 1.85198117827411 0.0160492405588343 0.0950667933580713 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/2103 36/18639 0.25 2.21576319543509 0.0162201737062341 0.0956217859443708 GO:0031491 nucleosome binding 15/2103 74/18639 0.202702702702703 1.79656475305548 0.016991935740188 0.0996967604092549 GO:0004843 cysteine-type deubiquitinase activity 20/2103 108/18639 0.185185185185185 1.64130607069266 0.0173898576679626 0.100320129814427 GO:0002020 protease binding 24/2103 136/18639 0.176470588235294 1.56406813795418 0.017411172139739 0.100320129814427 GO:0035401 histone H3Y41 kinase activity 21/2103 115/18639 0.182608695652174 1.61847050796998 0.0175033505976707 0.100320129814427 GO:0101005 deubiquitinase activity 21/2103 115/18639 0.182608695652174 1.61847050796998 0.0175033505976707 0.100320129814427 GO:0140801 histone H2AXY142 kinase activity 21/2103 115/18639 0.182608695652174 1.61847050796998 0.0175033505976707 0.100320129814427 GO:0017025 TBP-class protein binding 7/2103 25/18639 0.28 2.4816547788873 0.0177197424390679 0.101092355481871 GO:0140457 protein demethylase activity 8/2103 31/18639 0.258064516129032 2.2872394275459 0.0189642443277667 0.105710921642739 GO:0001094 TFIID-class transcription factor complex binding 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0003680 minor groove of adenine-thymine-rich DNA binding 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0005131 growth hormone receptor binding 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0016303 1-phosphatidylinositol-3-kinase activity 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0031720 haptoglobin binding 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0042975 peroxisome proliferator activated receptor binding 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0099122 RNA polymerase II C-terminal domain binding 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0140999 histone H3K4 trimethyltransferase activity 4/2103 10/18639 0.4 3.54522111269615 0.019383181916722 0.105710921642739 GO:0004129 cytochrome-c oxidase activity 5/2103 15/18639 0.333333333333333 2.95435092724679 0.0207084807321905 0.111465648462834 GO:0042809 nuclear vitamin D receptor binding 5/2103 15/18639 0.333333333333333 2.95435092724679 0.0207084807321905 0.111465648462834 GO:0051371 muscle alpha-actinin binding 5/2103 15/18639 0.333333333333333 2.95435092724679 0.0207084807321905 0.111465648462834 GO:0019208 phosphatase regulator activity 21/2103 117/18639 0.179487179487179 1.59080434544058 0.0209599167495512 0.112330636086339 GO:0140034 methylation-dependent protein binding 15/2103 76/18639 0.197368421052632 1.74928673323823 0.0213828651740682 0.114103392609898 GO:0052742 phosphatidylinositol kinase activity 7/2103 26/18639 0.269230769230769 2.38620651816087 0.0219466869542289 0.116609435404873 GO:0005178 integrin binding 27/2103 161/18639 0.167701863354037 1.48635046650304 0.022826379815977 0.120563487157669 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 9/2103 38/18639 0.236842105263158 2.09914407988588 0.0228856377076351 0.120563487157669 GO:0051117 ATPase binding 16/2103 84/18639 0.19047619047619 1.68820052985531 0.0244545078040082 0.128282545175263 GO:0051010 microtubule plus-end binding 6/2103 21/18639 0.285714285714286 2.53230079478296 0.0249455844116031 0.130306470470737 GO:0051539 4 iron, 4 sulfur cluster binding 10/2103 45/18639 0.222222222222222 1.96956728483119 0.0259470484191286 0.134968260264207 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 41/2103 268/18639 0.152985074626866 1.3559147912364 0.0265779866596224 0.137671746797542 GO:0042826 histone deacetylase binding 22/2103 127/18639 0.173228346456693 1.53533197793928 0.0267994139904208 0.138240310500587 GO:0032182 ubiquitin-like protein binding 21/2103 120/18639 0.175 1.55103423680456 0.0271051820255724 0.139237408081571 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/2103 16/18639 0.3125 2.76970399429387 0.0273855794647215 0.140096476765807 GO:0002162 dystroglycan binding 4/2103 11/18639 0.363636363636364 3.22292828426923 0.0277853870762254 0.14155682798505 GO:0051015 actin filament binding 33/2103 209/18639 0.157894736842105 1.39942938659058 0.0290593140612152 0.147440290195838 GO:0036002 pre-mRNA binding 12/2103 59/18639 0.203389830508475 1.80265480306584 0.0300166924337725 0.151206567139212 GO:0019887 protein kinase regulator activity 39/2103 255/18639 0.152941176470588 1.35552571956029 0.0300458929856592 0.151206567139212 GO:0044325 transmembrane transporter binding 23/2103 136/18639 0.169117647058824 1.49889863220609 0.0308454721517872 0.154602002121103 GO:0070034 telomerase RNA binding 6/2103 22/18639 0.272727272727273 2.41719621320192 0.0311157978666651 0.155328055479562 GO:0004532 RNA exonuclease activity 9/2103 40/18639 0.225 1.99418687589158 0.0313060061145168 0.155649942047276 GO:0051393 alpha-actinin binding 7/2103 28/18639 0.25 2.21576319543509 0.0323863316912993 0.159738161887763 GO:0051959 dynein light intermediate chain binding 7/2103 28/18639 0.25 2.21576319543509 0.0323863316912993 0.159738161887763 GO:0019955 cytokine binding 24/2103 144/18639 0.166666666666667 1.4771754636234 0.0325485042797486 0.159808970353313 GO:0048306 calcium-dependent protein binding 15/2103 80/18639 0.1875 1.66182239657632 0.0326588606618645 0.159808970353313 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 68/2103 484/18639 0.140495867768595 1.24522229164947 0.0331332277956698 0.16149187405921 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/2103 60/18639 0.2 1.77261055634807 0.0338038485282632 0.163473298742148 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 12/2103 60/18639 0.2 1.77261055634807 0.0338038485282632 0.163473298742148 GO:0043495 protein-membrane adaptor activity 10/2103 47/18639 0.212765957446809 1.88575591100859 0.0342864184668885 0.165161813470848 GO:0046965 nuclear retinoid X receptor binding 5/2103 17/18639 0.294117647058824 2.60678022992364 0.0352854206328165 0.169315312959019 GO:0035064 methylated histone binding 14/2103 74/18639 0.189189189189189 1.67679376951845 0.0356520197486944 0.170413901347041 GO:0000175 3'-5'-RNA exonuclease activity 8/2103 35/18639 0.228571428571429 2.02584063582637 0.0378099808209236 0.174404971276474 GO:0005154 epidermal growth factor receptor binding 8/2103 35/18639 0.228571428571429 2.02584063582637 0.0378099808209236 0.174404971276474 GO:0034061 DNA polymerase activity 8/2103 35/18639 0.228571428571429 2.02584063582637 0.0378099808209236 0.174404971276474 GO:0043015 gamma-tubulin binding 8/2103 35/18639 0.228571428571429 2.02584063582637 0.0378099808209236 0.174404971276474 GO:0003995 acyl-CoA dehydrogenase activity 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0016423 tRNA (guanine) methyltransferase activity 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0035197 siRNA binding 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0035259 nuclear glucocorticoid receptor binding 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0035497 cAMP response element binding 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/2103 12/18639 0.333333333333333 2.95435092724679 0.0380366253995542 0.174404971276474 GO:0030295 protein kinase activator activity 23/2103 139/18639 0.165467625899281 1.46654830201459 0.0384809714300395 0.175791301219147 GO:0032266 phosphatidylinositol-3-phosphate binding 10/2103 48/18639 0.208333333333333 1.84646932952924 0.0390878415019298 0.177255486371389 GO:0038187 pattern recognition receptor activity 10/2103 48/18639 0.208333333333333 1.84646932952924 0.0390878415019298 0.177255486371389 GO:0001216 DNA-binding transcription activator activity 68/2103 491/18639 0.138492871690428 1.22746963168706 0.0430058256612477 0.193583915151497 GO:0019209 kinase activator activity 24/2103 148/18639 0.162162162162162 1.43725180244438 0.0430970858090932 0.193583915151497 GO:0002039 p53 binding 13/2103 69/18639 0.188405797101449 1.66985052409601 0.0431576418269897 0.193583915151497 GO:0001222 transcription corepressor binding 10/2103 49/18639 0.204081632653061 1.80878628198783 0.0443319920450537 0.197246306255604 GO:0001217 DNA-binding transcription repressor activity 41/2103 278/18639 0.147482014388489 1.30714087788257 0.044343215736523 0.197246306255604 GO:0030228 lipoprotein particle receptor activity 5/2103 18/18639 0.277777777777778 2.46195910603899 0.0444521158685892 0.197246306255604 GO:0031625 ubiquitin protein ligase binding 44/2103 302/18639 0.145695364238411 1.29130570329992 0.0456160533444797 0.201688121573092 GO:0004527 exonuclease activity 15/2103 84/18639 0.178571428571429 1.58268799673935 0.0477505654653485 0.210374377388261 GO:0008035 high-density lipoprotein particle binding 4/2103 13/18639 0.307692307692308 2.72709316361242 0.0501647166654928 0.217146570740839 GO:0017154 semaphorin receptor activity 4/2103 13/18639 0.307692307692308 2.72709316361242 0.0501647166654928 0.217146570740839 GO:0032396 inhibitory MHC class I receptor activity 4/2103 13/18639 0.307692307692308 2.72709316361242 0.0501647166654928 0.217146570740839 GO:0043560 insulin receptor substrate binding 4/2103 13/18639 0.307692307692308 2.72709316361242 0.0501647166654928 0.217146570740839 GO:0140852 histone ubiquitin ligase activity 4/2103 13/18639 0.307692307692308 2.72709316361242 0.0501647166654928 0.217146570740839 GO:0042805 actinin binding 8/2103 37/18639 0.216216216216216 1.91633573659251 0.0507736103226311 0.219016479370792 GO:0019199 transmembrane receptor protein kinase activity 14/2103 78/18639 0.179487179487179 1.59080434544058 0.0525655725132159 0.225958954067227 GO:0019888 protein phosphatase regulator activity 18/2103 107/18639 0.168224299065421 1.4909808417881 0.0538949800612989 0.230871921508263 GO:0001046 core promoter sequence-specific DNA binding 9/2103 44/18639 0.204545454545455 1.81289715990144 0.0541126967358176 0.231005236410146 GO:0015662 P-type ion transporter activity 6/2103 25/18639 0.24 2.12713266761769 0.0552401741058331 0.233403875573452 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/2103 25/18639 0.24 2.12713266761769 0.0552401741058331 0.233403875573452 GO:0140358 P-type transmembrane transporter activity 6/2103 25/18639 0.24 2.12713266761769 0.0552401741058331 0.233403875573452 GO:0005021 vascular endothelial growth factor receptor activity 10/2103 51/18639 0.196078431372549 1.73785348661576 0.0562022432440858 0.236661146721695 GO:0017124 SH3 domain binding 19/2103 115/18639 0.165217391304348 1.46433045959189 0.0567121935855156 0.237998968335147 GO:0008408 3'-5' exonuclease activity 11/2103 58/18639 0.189655172413793 1.68092380343352 0.0573811258792689 0.239992681886942 GO:0016410 N-acyltransferase activity 16/2103 94/18639 0.170212765957447 1.50860472880687 0.0607557795693755 0.253251363996252 GO:0070717 poly-purine tract binding 7/2103 32/18639 0.21875 1.93879279600571 0.0620776994136436 0.257030742053816 GO:0120015 sterol transfer activity 7/2103 32/18639 0.21875 1.93879279600571 0.0620776994136436 0.257030742053816 GO:0005080 protein kinase C binding 10/2103 52/18639 0.192307692307692 1.70443322725776 0.0628501685878313 0.259361695705784 GO:0043539 protein serine/threonine kinase activator activity 13/2103 73/18639 0.178082191780822 1.57835186524144 0.063482160817737 0.261099385688898 GO:0005161 platelet-derived growth factor receptor binding 4/2103 14/18639 0.285714285714286 2.53230079478296 0.0641544758009925 0.261260661321147 GO:0005344 oxygen carrier activity 4/2103 14/18639 0.285714285714286 2.53230079478296 0.0641544758009925 0.261260661321147 GO:0030983 mismatched DNA binding 4/2103 14/18639 0.285714285714286 2.53230079478296 0.0641544758009925 0.261260661321147 GO:0008143 poly(A) binding 6/2103 26/18639 0.230769230769231 2.04531987270932 0.0652282202513143 0.263037578733313 GO:0034237 protein kinase A regulatory subunit binding 6/2103 26/18639 0.230769230769231 2.04531987270932 0.0652282202513143 0.263037578733313 GO:0043548 phosphatidylinositol 3-kinase binding 6/2103 26/18639 0.230769230769231 2.04531987270932 0.0652282202513143 0.263037578733313 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 5/2103 20/18639 0.25 2.21576319543509 0.0666640588249111 0.267087717881036 GO:0140939 histone H4 methyltransferase activity 5/2103 20/18639 0.25 2.21576319543509 0.0666640588249111 0.267087717881036 GO:0016651 oxidoreductase activity, acting on NAD(P)H 15/2103 88/18639 0.170454545454545 1.5107476332512 0.0671543411403302 0.268184110747512 GO:0022804 active transmembrane transporter activity 62/2103 457/18639 0.135667396061269 1.2024272920523 0.0710827265722664 0.282959535358411 GO:0071889 14-3-3 protein binding 7/2103 33/18639 0.212121212121212 1.88004149915705 0.071448345916871 0.283503372580405 GO:0008234 cysteine-type peptidase activity 28/2103 187/18639 0.149732620320856 1.32708811705203 0.0725303436562191 0.286877205899039 GO:0032451 demethylase activity 8/2103 40/18639 0.2 1.77261055634807 0.0750481781056752 0.294951252364526 GO:0050997 quaternary ammonium group binding 8/2103 40/18639 0.2 1.77261055634807 0.0750481781056752 0.294951252364526 GO:0005044 scavenger receptor activity 6/2103 27/18639 0.222222222222222 1.96956728483119 0.0762011624182278 0.297168392223948 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/2103 27/18639 0.222222222222222 1.96956728483119 0.0762011624182278 0.297168392223948 GO:0044389 ubiquitin-like protein ligase binding 45/2103 322/18639 0.139751552795031 1.23862538875254 0.0763324303127751 0.297168392223948 GO:1990841 promoter-specific chromatin binding 12/2103 68/18639 0.176470588235294 1.56406813795418 0.0767941074859477 0.298028542531672 GO:0017069 snRNA binding 10/2103 54/18639 0.185185185185185 1.64130607069266 0.0776098550217487 0.30025312661539 GO:0035613 RNA stem-loop binding 5/2103 21/18639 0.238095238095238 2.11025066231914 0.0797010820790698 0.304559501828985 GO:0004559 alpha-mannosidase activity 4/2103 15/18639 0.266666666666667 2.36348074179743 0.079953019462375 0.304559501828985 GO:0005041 low-density lipoprotein particle receptor activity 4/2103 15/18639 0.266666666666667 2.36348074179743 0.079953019462375 0.304559501828985 GO:0005523 tropomyosin binding 4/2103 15/18639 0.266666666666667 2.36348074179743 0.079953019462375 0.304559501828985 GO:0061578 K63-linked deubiquitinase activity 4/2103 15/18639 0.266666666666667 2.36348074179743 0.079953019462375 0.304559501828985 GO:0008135 translation factor activity, RNA binding 14/2103 83/18639 0.168674698795181 1.49497275836585 0.0805427576890106 0.305864828279126 GO:0030332 cyclin binding 7/2103 34/18639 0.205882352941176 1.82474616094655 0.0816111554732335 0.307096080473748 GO:0052866 phosphatidylinositol phosphate phosphatase activity 7/2103 34/18639 0.205882352941176 1.82474616094655 0.0816111554732335 0.307096080473748 GO:0090482 vitamin transmembrane transporter activity 7/2103 34/18639 0.205882352941176 1.82474616094655 0.0816111554732335 0.307096080473748 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/2103 41/18639 0.195121951219512 1.72937615253471 0.0844578831767144 0.315887792666986 GO:0042169 SH2 domain binding 8/2103 41/18639 0.195121951219512 1.72937615253471 0.0844578831767144 0.315887792666986 GO:0000149 SNARE binding 17/2103 106/18639 0.160377358490566 1.42143299329798 0.0856032530672447 0.319207311136292 GO:0180051 translation factor activity 14/2103 84/18639 0.166666666666667 1.4771754636234 0.0871011961337432 0.323817660100823 GO:0000182 rDNA binding 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0005031 tumor necrosis factor receptor activity 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0005522 profilin binding 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0008190 eukaryotic initiation factor 4E binding 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0008239 dipeptidyl-peptidase activity 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0031434 mitogen-activated protein kinase kinase binding 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0140940 histone H2A methyltransferase activity 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:1990259 histone H2AQ104 methyltransferase activity 3/2103 10/18639 0.3 2.65891583452211 0.0939187437816692 0.331511962914511 GO:0008093 cytoskeletal anchor activity 5/2103 22/18639 0.227272727272727 2.01433017766827 0.0939908715533065 0.331511962914511 GO:0034062 5'-3' RNA polymerase activity 5/2103 22/18639 0.227272727272727 2.01433017766827 0.0939908715533065 0.331511962914511 GO:0097747 RNA polymerase activity 5/2103 22/18639 0.227272727272727 2.01433017766827 0.0939908715533065 0.331511962914511 GO:0008307 structural constituent of muscle 8/2103 42/18639 0.19047619047619 1.68820052985531 0.0945266806980828 0.331512834856166 GO:0048487 beta-tubulin binding 8/2103 42/18639 0.19047619047619 1.68820052985531 0.0945266806980828 0.331512834856166 GO:0015562 efflux transmembrane transporter activity 4/2103 16/18639 0.25 2.21576319543509 0.0974754994615929 0.338024281046084 GO:0015923 mannosidase activity 4/2103 16/18639 0.25 2.21576319543509 0.0974754994615929 0.338024281046084 GO:0034450 ubiquitin-ubiquitin ligase activity 4/2103 16/18639 0.25 2.21576319543509 0.0974754994615929 0.338024281046084 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/2103 16/18639 0.25 2.21576319543509 0.0974754994615929 0.338024281046084 GO:0051213 dioxygenase activity 15/2103 93/18639 0.161290322580645 1.42952464221619 0.0979816136462464 0.338830272888416 GO:0099604 ligand-gated calcium channel activity 6/2103 29/18639 0.206896551724138 1.83373505829111 0.10105876625359 0.348497918166975 GO:0005006 epidermal growth factor receptor activity 9/2103 50/18639 0.18 1.59534950071327 0.10480056079152 0.360397484055283 GO:0004712 protein serine/threonine/tyrosine kinase activity 8/2103 43/18639 0.186046511627907 1.64894005241681 0.105248106521449 0.360933949788238 GO:0008171 O-methyltransferase activity 5/2103 23/18639 0.217391304347826 1.92675060472617 0.10948795818007 0.373405212746354 GO:0017134 fibroblast growth factor binding 5/2103 23/18639 0.217391304347826 1.92675060472617 0.10948795818007 0.373405212746354 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 6/2103 30/18639 0.2 1.77261055634807 0.114898535151965 0.385758046331257 GO:0031210 phosphatidylcholine binding 6/2103 30/18639 0.2 1.77261055634807 0.114898535151965 0.385758046331257 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2103 30/18639 0.2 1.77261055634807 0.114898535151965 0.385758046331257 GO:0005010 insulin-like growth factor receptor activity 9/2103 51/18639 0.176470588235294 1.56406813795418 0.115214485980256 0.385758046331257 GO:0004659 prenyltransferase activity 4/2103 17/18639 0.235294117647059 2.08542418393891 0.116610908331986 0.385758046331257 GO:0005092 GDP-dissociation inhibitor activity 4/2103 17/18639 0.235294117647059 2.08542418393891 0.116610908331986 0.385758046331257 GO:0030169 low-density lipoprotein particle binding 4/2103 17/18639 0.235294117647059 2.08542418393891 0.116610908331986 0.385758046331257 GO:0019205 nucleobase-containing compound kinase activity 8/2103 44/18639 0.181818181818182 1.61146414213461 0.116611530918256 0.385758046331257 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0008432 JUN kinase binding 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0032794 GTPase activating protein binding 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0048185 activin binding 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0050786 RAGE receptor binding 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0140537 transcription regulator activator activity 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2103 11/18639 0.272727272727273 2.41719621320192 0.118718752546211 0.385758046331257 GO:0004896 cytokine receptor activity 15/2103 96/18639 0.15625 1.38485199714693 0.120090465068379 0.389193706164015 GO:0048027 mRNA 5'-UTR binding 5/2103 24/18639 0.208333333333333 1.84646932952924 0.126133402304875 0.406648833472488 GO:0050431 transforming growth factor beta binding 5/2103 24/18639 0.208333333333333 1.84646932952924 0.126133402304875 0.406648833472488 GO:0008327 methyl-CpG binding 6/2103 31/18639 0.193548387096774 1.71542957065943 0.129634776586753 0.414792034658288 GO:0070325 lipoprotein particle receptor binding 6/2103 31/18639 0.193548387096774 1.71542957065943 0.129634776586753 0.414792034658288 GO:0000146 microfilament motor activity 7/2103 38/18639 0.184210526315789 1.63266761768902 0.129999442203082 0.414792034658288 GO:0042887 amide transmembrane transporter activity 7/2103 38/18639 0.184210526315789 1.63266761768902 0.129999442203082 0.414792034658288 GO:0003697 single-stranded DNA binding 18/2103 121/18639 0.148760330578512 1.3184706617465 0.134839963009111 0.429130782018714 GO:0042626 ATPase-coupled transmembrane transporter activity 15/2103 98/18639 0.153061224489796 1.35658971149087 0.136323929708135 0.432284733458509 GO:0016791 phosphatase activity 37/2103 273/18639 0.135531135531136 1.20121960778166 0.13688964705768 0.432284733458509 GO:0032393 MHC class I receptor activity 4/2103 18/18639 0.222222222222222 1.96956728483119 0.13722770617867 0.432284733458509 GO:0034185 apolipoprotein binding 4/2103 18/18639 0.222222222222222 1.96956728483119 0.13722770617867 0.432284733458509 GO:0003774 cytoskeletal motor activity 22/2103 153/18639 0.143790849673203 1.27442589018489 0.139287981334418 0.437661220538095 GO:0032934 sterol binding 11/2103 68/18639 0.161764705882353 1.433729126458 0.139656420432764 0.437707970875347 GO:1901981 phosphatidylinositol phosphate binding 26/2103 185/18639 0.140540540540541 1.24561822878513 0.140649156586684 0.439679610052184 GO:0003707 nuclear steroid receptor activity 5/2103 25/18639 0.2 1.77261055634807 0.143856709354636 0.439679610052184 GO:0120020 cholesterol transfer activity 5/2103 25/18639 0.2 1.77261055634807 0.143856709354636 0.439679610052184 GO:0071813 lipoprotein particle binding 6/2103 32/18639 0.1875 1.66182239657632 0.145224871319009 0.439679610052184 GO:0071814 protein-lipid complex binding 6/2103 32/18639 0.1875 1.66182239657632 0.145224871319009 0.439679610052184 GO:0004875 complement receptor activity 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0005078 MAP-kinase scaffold activity 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0005165 neurotrophin receptor binding 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0005247 voltage-gated chloride channel activity 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0016208 AMP binding 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0017166 vinculin binding 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0035251 UDP-glucosyltransferase activity 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0036009 protein-glutamine N-methyltransferase activity 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0070410 co-SMAD binding 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2103 12/18639 0.25 2.21576319543509 0.145612794928429 0.439679610052184 GO:0015485 cholesterol binding 9/2103 54/18639 0.166666666666667 1.4771754636234 0.149679523968942 0.449765171537744 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 9/2103 54/18639 0.166666666666667 1.4771754636234 0.149679523968942 0.449765171537744 GO:0031072 heat shock protein binding 19/2103 131/18639 0.145038167938931 1.28548093780967 0.151348779185415 0.45367987562117 GO:0043130 ubiquitin binding 15/2103 100/18639 0.15 1.32945791726106 0.153722917683733 0.459683507469715 GO:0005504 fatty acid binding 8/2103 47/18639 0.170212765957447 1.50860472880687 0.154388784616606 0.460053221120932 GO:0051540 metal cluster binding 12/2103 77/18639 0.155844155844156 1.38125497897253 0.154589773817696 0.460053221120932 GO:0015179 L-amino acid transmembrane transporter activity 10/2103 62/18639 0.161290322580645 1.42952464221619 0.156183052335423 0.46368014098622 GO:0004177 aminopeptidase activity 7/2103 40/18639 0.175 1.55103423680456 0.15854584252183 0.465871688501961 GO:0061791 GTPase motor activity 7/2103 40/18639 0.175 1.55103423680456 0.15854584252183 0.465871688501961 GO:1990606 membrane scission GTPase motor activity 7/2103 40/18639 0.175 1.55103423680456 0.15854584252183 0.465871688501961 GO:0046624 sphingolipid transporter activity 4/2103 19/18639 0.210526315789474 1.86590584878745 0.159179098736938 0.465871688501961 GO:0120227 acyl-CoA binding 4/2103 19/18639 0.210526315789474 1.86590584878745 0.159179098736938 0.465871688501961 GO:0140036 ubiquitin-modified protein reader activity 4/2103 19/18639 0.210526315789474 1.86590584878745 0.159179098736938 0.465871688501961 GO:0140375 immune receptor activity 22/2103 156/18639 0.141025641025641 1.24991769998903 0.160389439622665 0.468306901539761 GO:0140416 transcription regulator inhibitor activity 6/2103 33/18639 0.181818181818182 1.61146414213461 0.161619654741707 0.470788547224077 GO:0050750 low-density lipoprotein particle receptor binding 5/2103 26/18639 0.192307692307692 1.70443322725776 0.16257777818876 0.471361333484039 GO:0070412 R-SMAD binding 5/2103 26/18639 0.192307692307692 1.70443322725776 0.16257777818876 0.471361333484039 GO:0140098 catalytic activity, acting on RNA 50/2103 387/18639 0.129198966408269 1.14509725862279 0.171055325928974 0.494766184376721 GO:0001530 lipopolysaccharide binding 7/2103 41/18639 0.170731707317073 1.51320413346787 0.173799245916413 0.494766184376721 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/2103 41/18639 0.170731707317073 1.51320413346787 0.173799245916413 0.494766184376721 GO:0004535 poly(A)-specific ribonuclease activity 3/2103 13/18639 0.230769230769231 2.04531987270932 0.17424721840731 0.494766184376721 GO:0005035 death receptor activity 3/2103 13/18639 0.230769230769231 2.04531987270932 0.17424721840731 0.494766184376721 GO:0008253 5'-nucleotidase activity 3/2103 13/18639 0.230769230769231 2.04531987270932 0.17424721840731 0.494766184376721 GO:0035325 Toll-like receptor binding 3/2103 13/18639 0.230769230769231 2.04531987270932 0.17424721840731 0.494766184376721 GO:0035673 oligopeptide transmembrane transporter activity 3/2103 13/18639 0.230769230769231 2.04531987270932 0.17424721840731 0.494766184376721 GO:0097157 pre-mRNA intronic binding 3/2103 13/18639 0.230769230769231 2.04531987270932 0.17424721840731 0.494766184376721 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/2103 27/18639 0.185185185185185 1.64130607069266 0.182208827227517 0.500742586630417 GO:0016405 CoA-ligase activity 5/2103 27/18639 0.185185185185185 1.64130607069266 0.182208827227517 0.500742586630417 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 5/2103 27/18639 0.185185185185185 1.64130607069266 0.182208827227517 0.500742586630417 GO:0000339 RNA cap binding 4/2103 20/18639 0.2 1.77261055634807 0.182307858714945 0.500742586630417 GO:0043024 ribosomal small subunit binding 4/2103 20/18639 0.2 1.77261055634807 0.182307858714945 0.500742586630417 GO:0005004 GPI-linked ephrin receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0005008 hepatocyte growth factor receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0005009 insulin receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0005011 macrophage colony-stimulating factor receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0005020 stem cell factor receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0008288 boss receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0036332 placental growth factor receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0038062 protein tyrosine kinase collagen receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0060175 brain-derived neurotrophic factor receptor activity 8/2103 49/18639 0.163265306122449 1.44702902559026 0.182419149087495 0.500742586630417 GO:0016504 peptidase activator activity 9/2103 57/18639 0.157894736842105 1.39942938659058 0.188632234251125 0.516652004431178 GO:0051879 Hsp90 protein binding 7/2103 42/18639 0.166666666666667 1.4771754636234 0.189653758960079 0.518303208813637 GO:0016779 nucleotidyltransferase activity 19/2103 136/18639 0.139705882352941 1.23822060921373 0.192617507115365 0.525243334380666 GO:1901681 sulfur compound binding 36/2103 275/18639 0.130909090909091 1.16025418233692 0.193386438756971 0.526181123475011 GO:0005007 fibroblast growth factor receptor activity 8/2103 50/18639 0.16 1.41808844507846 0.197203642096251 0.531891304826055 GO:0005017 platelet-derived growth factor receptor activity 8/2103 50/18639 0.16 1.41808844507846 0.197203642096251 0.531891304826055 GO:0005019 platelet-derived growth factor beta-receptor activity 8/2103 50/18639 0.16 1.41808844507846 0.197203642096251 0.531891304826055 GO:0032813 tumor necrosis factor receptor superfamily binding 8/2103 50/18639 0.16 1.41808844507846 0.197203642096251 0.531891304826055 GO:0008195 phosphatidate phosphatase activity 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0016530 metallochaperone activity 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0032454 histone H3K9 demethylase activity 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0034236 protein kinase A catalytic subunit binding 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0044548 S100 protein binding 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0046030 inositol trisphosphate phosphatase activity 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0070742 C2H2 zinc finger domain binding 3/2103 14/18639 0.214285714285714 1.89922559608722 0.204272511845397 0.541518992857819 GO:0005123 death receptor binding 4/2103 21/18639 0.19047619047619 1.68820052985531 0.206450629688093 0.544959231458121 GO:0140312 cargo adaptor activity 4/2103 21/18639 0.19047619047619 1.68820052985531 0.206450629688093 0.544959231458121 GO:0008013 beta-catenin binding 15/2103 106/18639 0.141509433962264 1.25420558232175 0.212446287996994 0.557250654588326 GO:0003743 translation initiation factor activity 8/2103 51/18639 0.156862745098039 1.39028278929261 0.212457438582948 0.557250654588326 GO:0005030 neurotrophin receptor activity 8/2103 51/18639 0.156862745098039 1.39028278929261 0.212457438582948 0.557250654588326 GO:0043236 laminin binding 5/2103 29/18639 0.172413793103448 1.52811254857593 0.223822397902191 0.584582549795175 GO:0106222 lncRNA binding 5/2103 29/18639 0.172413793103448 1.52811254857593 0.223822397902191 0.584582549795175 GO:0033218 amide binding 32/2103 247/18639 0.129554655870445 1.14824975309997 0.22751748567769 0.592982415303117 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/2103 22/18639 0.181818181818182 1.61146414213461 0.231441687051378 0.600680940397497 GO:0140035 ubiquitin-like protein reader activity 4/2103 22/18639 0.181818181818182 1.61146414213461 0.231441687051378 0.600680940397497 GO:0030145 manganese ion binding 10/2103 68/18639 0.147058823529412 1.30339011496182 0.233524227783674 0.600755159911644 GO:0051536 iron-sulfur cluster binding 11/2103 76/18639 0.144736842105263 1.28281027104137 0.234669811727517 0.600755159911644 GO:0043178 alcohol binding 13/2103 92/18639 0.141304347826087 1.25238789307201 0.235114929558684 0.600755159911644 GO:0008252 nucleotidase activity 3/2103 15/18639 0.2 1.77261055634807 0.235352384941153 0.600755159911644 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/2103 15/18639 0.2 1.77261055634807 0.235352384941153 0.600755159911644 GO:0140776 protein-containing complex destabilizing activity 3/2103 15/18639 0.2 1.77261055634807 0.235352384941153 0.600755159911644 GO:0141050 histone H3K deacetylase activity 3/2103 15/18639 0.2 1.77261055634807 0.235352384941153 0.600755159911644 GO:0141051 histone H4K deacetylase activity 3/2103 15/18639 0.2 1.77261055634807 0.235352384941153 0.600755159911644 GO:0140303 intramembrane lipid transporter activity 7/2103 45/18639 0.155555555555556 1.37869709938184 0.240376944911072 0.612318225925734 GO:0005003 ephrin receptor activity 8/2103 53/18639 0.150943396226415 1.33781928780987 0.244230113516131 0.61646035416167 GO:0005005 transmembrane-ephrin receptor activity 8/2103 53/18639 0.150943396226415 1.33781928780987 0.244230113516131 0.61646035416167 GO:0017046 peptide hormone binding 8/2103 53/18639 0.150943396226415 1.33781928780987 0.244230113516131 0.61646035416167 GO:0038064 collagen receptor activity 8/2103 53/18639 0.150943396226415 1.33781928780987 0.244230113516131 0.61646035416167 GO:0008187 poly-pyrimidine tract binding 5/2103 30/18639 0.166666666666667 1.4771754636234 0.245607170452237 0.61646035416167 GO:0051721 protein phosphatase 2A binding 5/2103 30/18639 0.166666666666667 1.4771754636234 0.245607170452237 0.61646035416167 GO:0098918 structural constituent of synapse 5/2103 30/18639 0.166666666666667 1.4771754636234 0.245607170452237 0.61646035416167 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 9/2103 61/18639 0.147540983606557 1.30766352517481 0.24648455194671 0.61646035416167 GO:0019905 syntaxin binding 9/2103 61/18639 0.147540983606557 1.30766352517481 0.24648455194671 0.61646035416167 GO:0099186 structural constituent of postsynapse 4/2103 23/18639 0.173913043478261 1.54140048378093 0.257116156287443 0.6417536320239 GO:0030276 clathrin binding 7/2103 46/18639 0.152173913043478 1.34872542330832 0.258177564035733 0.643106286270095 GO:0042562 hormone binding 13/2103 94/18639 0.138297872340426 1.22574134215558 0.259515949584508 0.645142059408878 GO:0016209 antioxidant activity 12/2103 86/18639 0.13953488372093 1.23670503931261 0.260742102422103 0.646891228053233 GO:0000062 fatty-acyl-CoA binding 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0004708 MAP kinase kinase activity 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0005159 insulin-like growth factor receptor binding 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0005521 lamin binding 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0008296 3'-5'-DNA exonuclease activity 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0022858 alanine transmembrane transporter activity 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0030275 LRR domain binding 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0043023 ribosomal large subunit binding 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0140327 flippase activity 3/2103 16/18639 0.1875 1.66182239657632 0.267170127744128 0.649064633489684 GO:0005164 tumor necrosis factor receptor binding 5/2103 31/18639 0.161290322580645 1.42952464221619 0.267909553887907 0.649064633489684 GO:0016878 acid-thiol ligase activity 5/2103 31/18639 0.161290322580645 1.42952464221619 0.267909553887907 0.649064633489684 GO:0000217 DNA secondary structure binding 6/2103 39/18639 0.153846153846154 1.36354658180621 0.273540283282663 0.660043372907081 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/2103 39/18639 0.153846153846154 1.36354658180621 0.273540283282663 0.660043372907081 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 17/2103 128/18639 0.1328125 1.17712419757489 0.274040624938804 0.660043372907081 GO:0005507 copper ion binding 9/2103 63/18639 0.142857142857143 1.26615039739148 0.277440178091031 0.665641357512979 GO:1901682 sulfur compound transmembrane transporter activity 9/2103 63/18639 0.142857142857143 1.26615039739148 0.277440178091031 0.665641357512979 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 29/2103 229/18639 0.126637554585153 1.12239533043874 0.281767354776576 0.673207545815621 GO:0015149 hexose transmembrane transporter activity 4/2103 24/18639 0.166666666666667 1.4771754636234 0.283312707083957 0.673207545815621 GO:0015295 solute:proton symporter activity 4/2103 24/18639 0.166666666666667 1.4771754636234 0.283312707083957 0.673207545815621 GO:0055056 D-glucose transmembrane transporter activity 4/2103 24/18639 0.166666666666667 1.4771754636234 0.283312707083957 0.673207545815621 GO:0070300 phosphatidic acid binding 4/2103 24/18639 0.166666666666667 1.4771754636234 0.283312707083957 0.673207545815621 GO:0035591 signaling adaptor activity 17/2103 129/18639 0.131782945736434 1.16799920379524 0.28498205232355 0.675876974667731 GO:0004197 cysteine-type endopeptidase activity 12/2103 88/18639 0.136363636363636 1.20859810660096 0.28723976624765 0.679928930429428 GO:0004540 RNA nuclease activity 16/2103 121/18639 0.132231404958678 1.17197392155245 0.288144426897999 0.680768703243746 GO:0015106 bicarbonate transmembrane transporter activity 5/2103 32/18639 0.15625 1.38485199714693 0.290628939548814 0.685330718402726 GO:0030331 nuclear estrogen receptor binding 6/2103 40/18639 0.15 1.32945791726106 0.293833419887515 0.69025763533348 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/2103 40/18639 0.15 1.32945791726106 0.293833419887515 0.69025763533348 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 7/2103 48/18639 0.145833333333333 1.29252853067047 0.294814347437874 0.691250307060772 GO:0016798 hydrolase activity, acting on glycosyl bonds 17/2103 130/18639 0.130769230769231 1.15901459453528 0.296065063388773 0.692870602032705 GO:0008201 heparin binding 22/2103 172/18639 0.127906976744186 1.13364628603656 0.298219795530959 0.692893136843514 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2103 17/18639 0.176470588235294 1.56406813795418 0.299432817618158 0.692893136843514 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/2103 17/18639 0.176470588235294 1.56406813795418 0.299432817618158 0.692893136843514 GO:0032977 membrane insertase activity 3/2103 17/18639 0.176470588235294 1.56406813795418 0.299432817618158 0.692893136843514 GO:0036041 long-chain fatty acid binding 3/2103 17/18639 0.176470588235294 1.56406813795418 0.299432817618158 0.692893136843514 GO:1901567 fatty acid derivative binding 3/2103 17/18639 0.176470588235294 1.56406813795418 0.299432817618158 0.692893136843514 GO:0120013 lipid transfer activity 9/2103 65/18639 0.138461538461538 1.22719192362559 0.309415846974014 0.696315662048732 GO:0000030 mannosyltransferase activity 4/2103 25/18639 0.16 1.41808844507846 0.309875754270494 0.696315662048732 GO:0015645 fatty acid ligase activity 4/2103 25/18639 0.16 1.41808844507846 0.309875754270494 0.696315662048732 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/2103 25/18639 0.16 1.41808844507846 0.309875754270494 0.696315662048732 GO:0019211 phosphatase activator activity 4/2103 25/18639 0.16 1.41808844507846 0.309875754270494 0.696315662048732 GO:0120515 fatty acid-CoA ligase activity 4/2103 25/18639 0.16 1.41808844507846 0.309875754270494 0.696315662048732 GO:0004382 GDP phosphatase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0005528 FK506 binding 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0030957 Tat protein binding 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0047429 nucleoside triphosphate diphosphatase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0051864 histone H3K36 demethylase activity 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0070513 death domain binding 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0097177 mitochondrial ribosome binding 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0098505 G-rich strand telomeric DNA binding 2/2103 10/18639 0.2 1.77261055634807 0.313813728681547 0.696315662048732 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/2103 41/18639 0.146341463414634 1.29703211440103 0.314410706853991 0.696315662048732 GO:0017080 sodium channel regulator activity 6/2103 41/18639 0.146341463414634 1.29703211440103 0.314410706853991 0.696315662048732 GO:0005539 glycosaminoglycan binding 30/2103 242/18639 0.12396694214876 1.09872555145542 0.319392174850586 0.706084843687546 GO:0042578 phosphoric ester hydrolase activity 44/2103 363/18639 0.121212121212121 1.07430942808974 0.328881830705784 0.715460529695059 GO:0008308 voltage-gated monoatomic anion channel activity 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0015172 acidic amino acid transmembrane transporter activity 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0016854 racemase and epimerase activity 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0017075 syntaxin-1 binding 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0035615 clathrin adaptor activity 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0050811 GABA receptor binding 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2103 18/18639 0.166666666666667 1.4771754636234 0.331873839906057 0.715460529695059 GO:0005496 steroid binding 14/2103 108/18639 0.12962962962963 1.14891424948486 0.332365986006841 0.715460529695059 GO:0001540 amyloid-beta binding 11/2103 83/18639 0.132530120481928 1.17462145300174 0.33285897939324 0.715460529695059 GO:0019894 kinesin binding 6/2103 42/18639 0.142857142857143 1.26615039739148 0.335203531502976 0.715460529695059 GO:0004435 phosphatidylinositol phospholipase C activity 4/2103 26/18639 0.153846153846154 1.36354658180621 0.336657204467173 0.715460529695059 GO:0004529 DNA exonuclease activity 4/2103 26/18639 0.153846153846154 1.36354658180621 0.336657204467173 0.715460529695059 GO:0008157 protein phosphatase 1 binding 4/2103 26/18639 0.153846153846154 1.36354658180621 0.336657204467173 0.715460529695059 GO:0008198 ferrous iron binding 4/2103 26/18639 0.153846153846154 1.36354658180621 0.336657204467173 0.715460529695059 GO:0015145 monosaccharide transmembrane transporter activity 4/2103 26/18639 0.153846153846154 1.36354658180621 0.336657204467173 0.715460529695059 GO:0030247 polysaccharide binding 4/2103 26/18639 0.153846153846154 1.36354658180621 0.336657204467173 0.715460529695059 GO:0008175 tRNA methyltransferase activity 5/2103 34/18639 0.147058823529412 1.30339011496182 0.336925273677076 0.715460529695059 GO:0008376 acetylgalactosaminyltransferase activity 5/2103 34/18639 0.147058823529412 1.30339011496182 0.336925273677076 0.715460529695059 GO:0016831 carboxy-lyase activity 5/2103 34/18639 0.147058823529412 1.30339011496182 0.336925273677076 0.715460529695059 GO:0019825 oxygen binding 5/2103 34/18639 0.147058823529412 1.30339011496182 0.336925273677076 0.715460529695059 GO:0051427 hormone receptor binding 5/2103 34/18639 0.147058823529412 1.30339011496182 0.336925273677076 0.715460529695059 GO:0008173 RNA methyltransferase activity 9/2103 67/18639 0.134328358208955 1.1905593288905 0.342150676567897 0.724072713830866 GO:0016500 protein-hormone receptor activity 9/2103 67/18639 0.134328358208955 1.1905593288905 0.342150676567897 0.724072713830866 GO:0031593 polyubiquitin modification-dependent protein binding 8/2103 59/18639 0.135593220338983 1.20176986871056 0.346876501923955 0.728458306037139 GO:0004860 protein kinase inhibitor activity 11/2103 84/18639 0.130952380952381 1.16063786427552 0.347583027557786 0.728458306037139 GO:0030544 Hsp70 protein binding 7/2103 51/18639 0.137254901960784 1.21649744063103 0.351582006355 0.728458306037139 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0003953 NAD+ nucleosidase activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0005114 type II transforming growth factor beta receptor binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0005225 volume-sensitive anion channel activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0005536 D-glucose binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0008526 phosphatidylinositol transfer activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0034056 estrogen response element binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0043522 leucine zipper domain binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0070990 snRNP binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0140031 phosphorylation-dependent protein binding 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0180030 inositol phosphate kinase activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:1990948 ubiquitin ligase inhibitor activity 2/2103 11/18639 0.181818181818182 1.61146414213461 0.357168167822733 0.728458306037139 GO:0005319 lipid transporter activity 22/2103 178/18639 0.123595505617978 1.09543348987802 0.35802084695626 0.728996395611596 GO:0008266 poly(U) RNA binding 4/2103 27/18639 0.148148148148148 1.31304485655413 0.363517791813201 0.734440685012343 GO:0008238 exopeptidase activity 13/2103 102/18639 0.127450980392157 1.12960476630024 0.36423763089647 0.734440685012343 GO:0008381 mechanosensitive monoatomic ion channel activity 3/2103 19/18639 0.157894736842105 1.39942938659058 0.364254103875266 0.734440685012343 GO:0015245 fatty acid transmembrane transporter activity 3/2103 19/18639 0.157894736842105 1.39942938659058 0.364254103875266 0.734440685012343 GO:0042577 lipid phosphatase activity 3/2103 19/18639 0.157894736842105 1.39942938659058 0.364254103875266 0.734440685012343 GO:0046527 glucosyltransferase activity 3/2103 19/18639 0.157894736842105 1.39942938659058 0.364254103875266 0.734440685012343 GO:0016836 hydro-lyase activity 8/2103 61/18639 0.131147540983607 1.16236757793316 0.382465020609801 0.768722969866562 GO:0005484 SNAP receptor activity 5/2103 36/18639 0.138888888888889 1.2309795530195 0.383740545539205 0.768722969866562 GO:0045505 dynein intermediate chain binding 5/2103 36/18639 0.138888888888889 1.2309795530195 0.383740545539205 0.768722969866562 GO:0055106 ubiquitin-protein transferase regulator activity 5/2103 36/18639 0.138888888888889 1.2309795530195 0.383740545539205 0.768722969866562 GO:0051119 sugar transmembrane transporter activity 4/2103 28/18639 0.142857142857143 1.26615039739148 0.390328048029651 0.770645155729101 GO:0016505 peptidase activator activity involved in apoptotic process 3/2103 20/18639 0.15 1.32945791726106 0.396362264785911 0.770645155729101 GO:0030742 GTP-dependent protein binding 3/2103 20/18639 0.15 1.32945791726106 0.396362264785911 0.770645155729101 GO:0052745 inositol phosphate phosphatase activity 3/2103 20/18639 0.15 1.32945791726106 0.396362264785911 0.770645155729101 GO:0061608 nuclear import signal receptor activity 3/2103 20/18639 0.15 1.32945791726106 0.396362264785911 0.770645155729101 GO:0140664 ATP-dependent DNA damage sensor activity 3/2103 20/18639 0.15 1.32945791726106 0.396362264785911 0.770645155729101 GO:0004300 enoyl-CoA hydratase activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0005095 GTPase inhibitor activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0005527 macrolide binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0008179 adenylate cyclase binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0008603 cAMP-dependent protein kinase regulator activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0015166 polyol transmembrane transporter activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0016273 arginine N-methyltransferase activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0016274 protein-arginine N-methyltransferase activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0043047 single-stranded telomeric DNA binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0045295 gamma-catenin binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0070008 serine-type exopeptidase activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0097371 MDM2/MDM4 family protein binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0140900 chloride:bicarbonate antiporter activity 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:1990459 transferrin receptor binding 2/2103 12/18639 0.166666666666667 1.4771754636234 0.399479242401593 0.770645155729101 GO:0016835 carbon-oxygen lyase activity 10/2103 79/18639 0.126582278481013 1.12190541541017 0.400262387022465 0.770645155729101 GO:0033293 monocarboxylic acid binding 10/2103 79/18639 0.126582278481013 1.12190541541017 0.400262387022465 0.770645155729101 GO:0019213 deacetylase activity 5/2103 37/18639 0.135135135135135 1.19770983537032 0.407124254170623 0.781426087849971 GO:0043394 proteoglycan binding 5/2103 37/18639 0.135135135135135 1.19770983537032 0.407124254170623 0.781426087849971 GO:0004518 nuclease activity 25/2103 209/18639 0.119617224880383 1.06017377772014 0.409595088211313 0.784951577717655 GO:0004629 phospholipase C activity 4/2103 29/18639 0.137931034482759 1.22249003886074 0.416968952050044 0.796616609009188 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/2103 29/18639 0.137931034482759 1.22249003886074 0.416968952050044 0.796616609009188 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/2103 46/18639 0.130434782608696 1.1560503628357 0.419219688859038 0.798452268934598 GO:0030291 protein serine/threonine kinase inhibitor activity 6/2103 46/18639 0.130434782608696 1.1560503628357 0.419219688859038 0.798452268934598 GO:0030246 carbohydrate binding 33/2103 280/18639 0.117857142857143 1.04457407784797 0.422338331592389 0.803156458542822 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/2103 21/18639 0.142857142857143 1.26615039739148 0.42801420396888 0.806516871405592 GO:0001846 opsonin binding 3/2103 21/18639 0.142857142857143 1.26615039739148 0.42801420396888 0.806516871405592 GO:0005248 voltage-gated sodium channel activity 3/2103 21/18639 0.142857142857143 1.26615039739148 0.42801420396888 0.806516871405592 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2103 21/18639 0.142857142857143 1.26615039739148 0.42801420396888 0.806516871405592 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/2103 21/18639 0.142857142857143 1.26615039739148 0.42801420396888 0.806516871405592 GO:0072542 protein phosphatase activator activity 3/2103 21/18639 0.142857142857143 1.26615039739148 0.42801420396888 0.806516871405592 GO:0043531 ADP binding 5/2103 38/18639 0.131578947368421 1.16619115549215 0.430385381042544 0.809752434241139 GO:0019210 kinase inhibitor activity 11/2103 90/18639 0.122222222222222 1.08326200665716 0.437341096099559 0.821590708605848 GO:0140359 ABC-type transporter activity 6/2103 47/18639 0.127659574468085 1.13145354660515 0.440128823750495 0.82240268948783 GO:0005172 vascular endothelial growth factor receptor binding 2/2103 13/18639 0.153846153846154 1.36354658180621 0.440430519491463 0.82240268948783 GO:0005542 folic acid binding 2/2103 13/18639 0.153846153846154 1.36354658180621 0.440430519491463 0.82240268948783 GO:0019104 DNA N-glycosylase activity 2/2103 13/18639 0.153846153846154 1.36354658180621 0.440430519491463 0.82240268948783 GO:0015215 nucleotide transmembrane transporter activity 4/2103 30/18639 0.133333333333333 1.18174037089872 0.443332303065091 0.826574384329191 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 11/2103 91/18639 0.120879120879121 1.07135802856202 0.45232838274594 0.842079004269886 GO:0015297 antiporter activity 16/2103 135/18639 0.118518518518519 1.0504358852433 0.457026202170539 0.845693956264694 GO:0003684 damaged DNA binding 9/2103 74/18639 0.121621621621622 1.07793885183329 0.458978342149857 0.845693956264694 GO:0004407 histone deacetylase activity 3/2103 22/18639 0.136363636363636 1.20859810660096 0.45905196979796 0.845693956264694 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/2103 22/18639 0.136363636363636 1.20859810660096 0.45905196979796 0.845693956264694 GO:0016881 acid-amino acid ligase activity 3/2103 22/18639 0.136363636363636 1.20859810660096 0.45905196979796 0.845693956264694 GO:0033558 protein lysine deacetylase activity 3/2103 22/18639 0.136363636363636 1.20859810660096 0.45905196979796 0.845693956264694 GO:0061133 endopeptidase activator activity 3/2103 22/18639 0.136363636363636 1.20859810660096 0.45905196979796 0.845693956264694 GO:0030165 PDZ domain binding 10/2103 83/18639 0.120481927710843 1.06783768454703 0.463398605643274 0.852433096265042 GO:0004601 peroxidase activity 7/2103 57/18639 0.12280701754386 1.08844507845934 0.466722358072349 0.857273411414789 GO:0005452 solute:inorganic anion antiporter activity 4/2103 31/18639 0.129032258064516 1.14361971377295 0.469320858498748 0.858226326176439 GO:0047499 calcium-independent phospholipase A2 activity 4/2103 31/18639 0.129032258064516 1.14361971377295 0.469320858498748 0.858226326176439 GO:0072349 modified amino acid transmembrane transporter activity 4/2103 31/18639 0.129032258064516 1.14361971377295 0.469320858498748 0.858226326176439 GO:0015144 carbohydrate transmembrane transporter activity 5/2103 40/18639 0.125 1.10788159771755 0.476253324696604 0.863343389595061 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/2103 40/18639 0.125 1.10788159771755 0.476253324696604 0.863343389595061 GO:0005313 L-glutamate transmembrane transporter activity 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0005347 ATP transmembrane transporter activity 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0008174 mRNA methyltransferase activity 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0008494 translation activator activity 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0008559 ABC-type xenobiotic transporter activity 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0019992 diacylglycerol binding 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0071933 Arp2/3 complex binding 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0098847 sequence-specific single stranded DNA binding 2/2103 14/18639 0.142857142857143 1.26615039739148 0.479790187432473 0.863343389595061 GO:0060590 ATPase regulator activity 6/2103 49/18639 0.122448979591837 1.0852717691927 0.481447265464768 0.865067800646419 GO:0004602 glutathione peroxidase activity 3/2103 23/18639 0.130434782608696 1.1560503628357 0.489342341824537 0.877979448085184 GO:0022884 macromolecule transmembrane transporter activity 4/2103 32/18639 0.125 1.10788159771755 0.494848275491596 0.882740871842357 GO:0031369 translation initiation factor binding 4/2103 32/18639 0.125 1.10788159771755 0.494848275491596 0.882740871842357 GO:0042910 xenobiotic transmembrane transporter activity 4/2103 32/18639 0.125 1.10788159771755 0.494848275491596 0.882740871842357 GO:0140142 nucleocytoplasmic carrier activity 4/2103 32/18639 0.125 1.10788159771755 0.494848275491596 0.882740871842357 GO:0140318 protein transporter activity 5/2103 41/18639 0.121951219512195 1.08086009533419 0.498731466063633 0.888387848901838 GO:0005200 structural constituent of cytoskeleton 13/2103 112/18639 0.116071428571429 1.02874719788058 0.500932912017131 0.891027219938518 GO:0015459 potassium channel regulator activity 7/2103 59/18639 0.11864406779661 1.05154863512174 0.504265896602984 0.893106123025028 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/2103 59/18639 0.11864406779661 1.05154863512174 0.504265896602984 0.893106123025028 GO:0070888 E-box binding 7/2103 59/18639 0.11864406779661 1.05154863512174 0.504265896602984 0.893106123025028 GO:0070851 growth factor receptor binding 16/2103 139/18639 0.115107913669065 1.02020751444493 0.505889328570744 0.893425090970871 GO:0140767 enzyme-substrate adaptor activity 16/2103 139/18639 0.115107913669065 1.02020751444493 0.505889328570744 0.893425090970871 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 10/2103 86/18639 0.116279069767442 1.03058753276051 0.510032126011128 0.898032502049282 GO:0004953 icosanoid receptor activity 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0015116 sulfate transmembrane transporter activity 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0015929 hexosaminidase activity 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0016846 carbon-sulfur lyase activity 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0031005 filamin binding 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0033130 acetylcholine receptor binding 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0050700 CARD domain binding 2/2103 15/18639 0.133333333333333 1.18174037089872 0.517396003200369 0.898032502049282 GO:0005540 hyaluronic acid binding 3/2103 24/18639 0.125 1.10788159771755 0.518775146787478 0.898032502049282 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/2103 24/18639 0.125 1.10788159771755 0.518775146787478 0.898032502049282 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/2103 24/18639 0.125 1.10788159771755 0.518775146787478 0.898032502049282 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/2103 24/18639 0.125 1.10788159771755 0.518775146787478 0.898032502049282 GO:0140612 DNA damage sensor activity 3/2103 24/18639 0.125 1.10788159771755 0.518775146787478 0.898032502049282 GO:0030296 protein tyrosine kinase activator activity 4/2103 33/18639 0.121212121212121 1.07430942808974 0.519838891168258 0.898032502049282 GO:0004520 DNA endonuclease activity 5/2103 42/18639 0.119047619047619 1.05512533115957 0.520829835598857 0.898032502049282 GO:0016859 cis-trans isomerase activity 5/2103 42/18639 0.119047619047619 1.05512533115957 0.520829835598857 0.898032502049282 GO:0031492 nucleosomal DNA binding 5/2103 42/18639 0.119047619047619 1.05512533115957 0.520829835598857 0.898032502049282 GO:0030159 signaling receptor complex adaptor activity 6/2103 52/18639 0.115384615384615 1.02265993635466 0.54147957216238 0.932338957353305 GO:0015020 glucuronosyltransferase activity 4/2103 34/18639 0.117647058823529 1.04271209196946 0.544227373500415 0.933978940995342 GO:0008139 nuclear localization sequence binding 3/2103 25/18639 0.12 1.06356633380884 0.547261427585248 0.933978940995342 GO:0008483 transaminase activity 3/2103 25/18639 0.12 1.06356633380884 0.547261427585248 0.933978940995342 GO:0017056 structural constituent of nuclear pore 3/2103 25/18639 0.12 1.06356633380884 0.547261427585248 0.933978940995342 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/2103 25/18639 0.12 1.06356633380884 0.547261427585248 0.933978940995342 GO:0019707 protein-cysteine S-acyltransferase activity 3/2103 25/18639 0.12 1.06356633380884 0.547261427585248 0.933978940995342 GO:0003688 DNA replication origin binding 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0004707 MAP kinase activity 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0005024 transforming growth factor beta receptor activity 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0017070 U6 snRNA binding 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0140328 floppase activity 2/2103 16/18639 0.125 1.10788159771755 0.553142556836975 0.933978940995342 GO:0051087 protein-folding chaperone binding 15/2103 134/18639 0.111940298507463 0.992132774075415 0.553748418974621 0.933978940995342 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 10/2103 89/18639 0.112359550561798 0.995848627161839 0.555406257220223 0.934229546791624 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 10/2103 89/18639 0.112359550561798 0.995848627161839 0.555406257220223 0.934229546791624 GO:0140299 molecular sensor activity 8/2103 71/18639 0.112676056338028 0.998653834562295 0.557298959948329 0.936141265150653 GO:0016251 RNA polymerase II general transcription initiation factor activity 6/2103 53/18639 0.113207547169811 1.0033644658574 0.560812108670283 0.940766111834432 GO:0004623 phospholipase A2 activity 4/2103 35/18639 0.114285714285714 1.01292031791319 0.567958271089055 0.9514646002818 GO:0140793 histone H2AXY142 phosphatase activity 10/2103 90/18639 0.111111111111111 0.984783642415597 0.570164402360305 0.952500202183975 GO:0015101 organic cation transmembrane transporter activity 9/2103 81/18639 0.111111111111111 0.984783642415597 0.571751678632244 0.952500202183975 GO:0005112 Notch binding 3/2103 26/18639 0.115384615384615 1.02265993635466 0.574731543644127 0.952500202183975 GO:0005160 transforming growth factor beta receptor binding 3/2103 26/18639 0.115384615384615 1.02265993635466 0.574731543644127 0.952500202183975 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/2103 26/18639 0.115384615384615 1.02265993635466 0.574731543644127 0.952500202183975 GO:0015216 purine nucleotide transmembrane transporter activity 3/2103 26/18639 0.115384615384615 1.02265993635466 0.574731543644127 0.952500202183975 GO:0030507 spectrin binding 3/2103 26/18639 0.115384615384615 1.02265993635466 0.574731543644127 0.952500202183975 GO:0070006 metalloaminopeptidase activity 3/2103 26/18639 0.115384615384615 1.02265993635466 0.574731543644127 0.952500202183975 GO:0051287 NAD binding 6/2103 54/18639 0.111111111111111 0.984783642415597 0.579750010302536 0.95627241882561 GO:0072341 modified amino acid binding 10/2103 91/18639 0.10989010989011 0.973961844147294 0.58471205910282 0.95627241882561 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0008429 phosphatidylethanolamine binding 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0008569 minus-end-directed microtubule motor activity 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0016018 cyclosporin A binding 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0017110 nucleoside diphosphate phosphatase activity 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0019198 transmembrane receptor protein phosphatase activity 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0051787 misfolded protein binding 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0070492 oligosaccharide binding 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:1990226 histone methyltransferase binding 2/2103 17/18639 0.117647058823529 1.04271209196946 0.58697052206615 0.95627241882561 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 9/2103 82/18639 0.109756097560976 0.972774085800772 0.587049303964026 0.95627241882561 GO:0004190 aspartic-type endopeptidase activity 4/2103 36/18639 0.111111111111111 0.984783642415597 0.590985486782787 0.957644021776296 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/2103 36/18639 0.111111111111111 0.984783642415597 0.590985486782787 0.957644021776296 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/2103 36/18639 0.111111111111111 0.984783642415597 0.590985486782787 0.957644021776296 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/2103 36/18639 0.111111111111111 0.984783642415597 0.590985486782787 0.957644021776296 GO:0004536 DNA nuclease activity 7/2103 64/18639 0.109375 0.969396398002853 0.593574549745076 0.960582081809679 GO:0098632 cell-cell adhesion mediator activity 6/2103 55/18639 0.109090909090909 0.966878485280768 0.598265489204304 0.965243812097621 GO:0140313 molecular sequestering activity 6/2103 55/18639 0.109090909090909 0.966878485280768 0.598265489204304 0.965243812097621 GO:0001671 ATPase activator activity 3/2103 27/18639 0.111111111111111 0.984783642415597 0.601133262622993 0.965243812097621 GO:0004364 glutathione transferase activity 3/2103 27/18639 0.111111111111111 0.984783642415597 0.601133262622993 0.965243812097621 GO:0005385 zinc ion transmembrane transporter activity 3/2103 27/18639 0.111111111111111 0.984783642415597 0.601133262622993 0.965243812097621 GO:0008320 protein transmembrane transporter activity 3/2103 27/18639 0.111111111111111 0.984783642415597 0.601133262622993 0.965243812097621 GO:0048029 monosaccharide binding 8/2103 74/18639 0.108108108108108 0.958167868296256 0.605811932577778 0.971398158495311 GO:0004721 phosphoprotein phosphatase activity 19/2103 175/18639 0.108571428571429 0.962274302017526 0.606644768351557 0.971398158495311 GO:1902936 phosphatidylinositol bisphosphate binding 12/2103 111/18639 0.108108108108108 0.958167868296256 0.607320011854096 0.971398158495311 GO:0015171 amino acid transmembrane transporter activity 11/2103 102/18639 0.107843137254902 0.955819417638668 0.609983800504172 0.973462725582938 GO:0000287 magnesium ion binding 25/2103 230/18639 0.108695652173913 0.963375302363084 0.610183420882359 0.973462725582938 GO:0070001 aspartic-type peptidase activity 4/2103 37/18639 0.108108108108108 0.958167868296256 0.613271696796382 0.977130451266308 GO:0003746 translation elongation factor activity 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:0008409 5'-3' exonuclease activity 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:0008525 phosphatidylcholine transporter activity 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:0070628 proteasome binding 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:1901611 phosphatidylglycerol binding 2/2103 18/18639 0.111111111111111 0.984783642415597 0.618857607336162 0.977226680972154 GO:0045499 chemorepellent activity 3/2103 28/18639 0.107142857142857 0.949612798043611 0.626429888374194 0.982445499960633 GO:0046625 sphingolipid binding 3/2103 28/18639 0.107142857142857 0.949612798043611 0.626429888374194 0.982445499960633 GO:0051019 mitogen-activated protein kinase binding 3/2103 28/18639 0.107142857142857 0.949612798043611 0.626429888374194 0.982445499960633 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/2103 28/18639 0.107142857142857 0.949612798043611 0.626429888374194 0.982445499960633 GO:0097718 disordered domain specific binding 3/2103 28/18639 0.107142857142857 0.949612798043611 0.626429888374194 0.982445499960633 GO:0008235 metalloexopeptidase activity 7/2103 66/18639 0.106060606060606 0.940020749578524 0.626924026630776 0.982445499960633 GO:0005501 retinoid binding 4/2103 38/18639 0.105263157894737 0.932952924393723 0.634787733943893 0.985793106100724 GO:0019840 isoprenoid binding 4/2103 38/18639 0.105263157894737 0.932952924393723 0.634787733943893 0.985793106100724 GO:0004857 enzyme inhibitor activity 45/2103 416/18639 0.108173076923077 0.958743690332492 0.64248997571158 0.985793106100724 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/2103 48/18639 0.104166666666667 0.923234664764622 0.643069474134955 0.985793106100724 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0030506 ankyrin binding 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0031420 alkali metal ion binding 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0034987 immunoglobulin receptor binding 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0043395 heparan sulfate proteoglycan binding 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0050145 nucleoside monophosphate kinase activity 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0097001 ceramide binding 2/2103 19/18639 0.105263157894737 0.932952924393723 0.648810960684503 0.985793106100724 GO:0003785 actin monomer binding 3/2103 29/18639 0.103448275862069 0.916867529145556 0.650598457950058 0.985793106100724 GO:0004181 metallocarboxypeptidase activity 3/2103 29/18639 0.103448275862069 0.916867529145556 0.650598457950058 0.985793106100724 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/2103 29/18639 0.103448275862069 0.916867529145556 0.650598457950058 0.985793106100724 GO:0016417 S-acyltransferase activity 3/2103 29/18639 0.103448275862069 0.916867529145556 0.650598457950058 0.985793106100724 GO:0051861 glycolipid binding 3/2103 29/18639 0.103448275862069 0.916867529145556 0.650598457950058 0.985793106100724 GO:0097472 cyclin-dependent protein kinase activity 3/2103 29/18639 0.103448275862069 0.916867529145556 0.650598457950058 0.985793106100724 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/2103 39/18639 0.102564102564103 0.909031054537474 0.655511950783713 0.985793106100724 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/2103 39/18639 0.102564102564103 0.909031054537474 0.655511950783713 0.985793106100724 GO:0016853 isomerase activity 19/2103 180/18639 0.105555555555556 0.935544460294817 0.65659343545246 0.985793106100724 GO:0003777 microtubule motor activity 7/2103 68/18639 0.102941176470588 0.912373080473273 0.658684363643058 0.985793106100724 GO:0035254 glutamate receptor binding 5/2103 49/18639 0.102040816326531 0.904393140993915 0.661435634211112 0.985793106100724 GO:0001786 phosphatidylserine binding 6/2103 59/18639 0.101694915254237 0.901327401532919 0.667669568274319 0.985793106100724 GO:0016769 transferase activity, transferring nitrogenous groups 3/2103 30/18639 0.1 0.886305278174037 0.673628030715054 0.985793106100724 GO:0001614 purinergic nucleotide receptor activity 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0001972 retinoic acid binding 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0015095 magnesium ion transmembrane transporter activity 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0016004 phospholipase activator activity 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0016408 C-acyltransferase activity 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0016502 nucleotide receptor activity 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0042288 MHC class I protein binding 2/2103 20/18639 0.1 0.886305278174037 0.676860815784347 0.985793106100724 GO:0015605 organophosphate ester transmembrane transporter activity 5/2103 50/18639 0.1 0.886305278174037 0.679177360212934 0.985793106100724 GO:0004725 protein tyrosine phosphatase activity 10/2103 98/18639 0.102040816326531 0.904393140993915 0.67957308767309 0.985793106100724 GO:1990782 protein tyrosine kinase binding 12/2103 117/18639 0.102564102564103 0.909031054537474 0.680647546528716 0.985793106100724 GO:0140789 histone phosphatase activity 14/2103 136/18639 0.102941176470588 0.912373080473273 0.682631457395072 0.985793106100724 GO:0004519 endonuclease activity 13/2103 127/18639 0.102362204724409 0.907241623327754 0.687069807659177 0.985793106100724 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/2103 31/18639 0.0967741935483871 0.857714785329713 0.695518084881087 0.985793106100724 GO:0016411 acylglycerol O-acyltransferase activity 3/2103 31/18639 0.0967741935483871 0.857714785329713 0.695518084881087 0.985793106100724 GO:0070273 phosphatidylinositol-4-phosphate binding 3/2103 31/18639 0.0967741935483871 0.857714785329713 0.695518084881087 0.985793106100724 GO:0005272 sodium channel activity 5/2103 51/18639 0.0980392156862745 0.868926743307879 0.696285350883903 0.985793106100724 GO:0016830 carbon-carbon lyase activity 5/2103 51/18639 0.0980392156862745 0.868926743307879 0.696285350883903 0.985793106100724 GO:0003796 lysozyme activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0004935 adrenergic receptor activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0005345 purine nucleobase transmembrane transporter activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0008140 cAMP response element binding protein binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0015187 glycine transmembrane transporter activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0015203 polyamine transmembrane transporter activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0015643 toxic substance binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0016868 intramolecular phosphotransferase activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0019531 oxalate transmembrane transporter activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0031419 cobalamin binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0031996 thioesterase binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0035256 G protein-coupled glutamate receptor binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0043295 glutathione binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0043422 protein kinase B binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0050308 sugar-phosphatase activity 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0050815 phosphoserine residue binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0051880 G-quadruplex DNA binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0071723 lipopeptide binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:1905394 retromer complex binding 1/2103 10/18639 0.1 0.886305278174037 0.698042961203502 0.985793106100724 GO:0015085 calcium ion transmembrane transporter activity 15/2103 147/18639 0.102040816326531 0.904393140993915 0.699111636704598 0.985793106100724 GO:0015026 coreceptor activity 6/2103 61/18639 0.0983606557377049 0.871775683449873 0.699364231634519 0.985793106100724 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:0010314 phosphatidylinositol-5-phosphate binding 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:0036122 BMP binding 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:0051428 peptide hormone receptor binding 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:0061891 calcium ion sensor activity 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:0070182 DNA polymerase binding 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:1904047 S-adenosyl-L-methionine binding 2/2103 21/18639 0.0952380952380952 0.844100264927654 0.703055195975448 0.985793106100724 GO:0033192 calmodulin-dependent protein phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0140791 histone H2AXS140 phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/2103 81/18639 0.0987654320987654 0.875363237702753 0.707261621786038 0.985793106100724 GO:0004222 metalloendopeptidase activity 11/2103 110/18639 0.1 0.886305278174037 0.709182457504412 0.985793106100724 GO:0042056 chemoattractant activity 4/2103 42/18639 0.0952380952380952 0.844100264927654 0.712816520441133 0.985793106100724 GO:0030515 snoRNA binding 3/2103 32/18639 0.09375 0.83091119828816 0.716277030679999 0.985793106100724 GO:0047498 calcium-dependent phospholipase A2 activity 3/2103 32/18639 0.09375 0.83091119828816 0.716277030679999 0.985793106100724 GO:0051059 NF-kappaB binding 3/2103 32/18639 0.09375 0.83091119828816 0.716277030679999 0.985793106100724 GO:0008509 monoatomic anion transmembrane transporter activity 15/2103 149/18639 0.100671140939597 0.892253635745675 0.71877697689723 0.985793106100724 GO:0033549 MAP kinase phosphatase activity 8/2103 82/18639 0.0975609756097561 0.864688076267353 0.720257548037066 0.985793106100724 GO:0031406 carboxylic acid binding 19/2103 187/18639 0.101604278074866 0.900524079428166 0.720593012774719 0.985793106100724 GO:0008649 rRNA methyltransferase activity 2/2103 22/18639 0.0909090909090909 0.805732071067306 0.727455518593197 0.985793106100724 GO:0008970 phospholipase A1 activity 2/2103 22/18639 0.0909090909090909 0.805732071067306 0.727455518593197 0.985793106100724 GO:0015377 chloride:monoatomic cation symporter activity 2/2103 22/18639 0.0909090909090909 0.805732071067306 0.727455518593197 0.985793106100724 GO:0033691 sialic acid binding 2/2103 22/18639 0.0909090909090909 0.805732071067306 0.727455518593197 0.985793106100724 GO:0140784 metal ion sensor activity 2/2103 22/18639 0.0909090909090909 0.805732071067306 0.727455518593197 0.985793106100724 GO:0004864 protein phosphatase inhibitor activity 5/2103 53/18639 0.0943396226415094 0.836137054881167 0.728581336380979 0.985793106100724 GO:0005245 voltage-gated calcium channel activity 4/2103 43/18639 0.0930232558139535 0.824470026208407 0.730284991791091 0.985793106100724 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/2103 43/18639 0.0930232558139535 0.824470026208407 0.730284991791091 0.985793106100724 GO:0004521 RNA endonuclease activity 7/2103 73/18639 0.0958904109589041 0.849881773591542 0.730546264863101 0.985793106100724 GO:0061134 peptidase regulator activity 23/2103 226/18639 0.101769911504425 0.901992097256763 0.731777772864339 0.985793106100724 GO:0001851 complement component C3b binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0008046 axon guidance receptor activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0008199 ferric iron binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0015205 nucleobase transmembrane transporter activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0015217 ADP transmembrane transporter activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0019107 myristoyltransferase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0019203 carbohydrate phosphatase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0019206 nucleoside kinase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0019215 intermediate filament binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0032050 clathrin heavy chain binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0034511 U3 snoRNA binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0034713 type I transforming growth factor beta receptor binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0035252 UDP-xylosyltransferase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0042285 xylosyltransferase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0045294 alpha-catenin binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0047676 arachidonate-CoA ligase activity 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0050998 nitric-oxide synthase binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:1900750 oligopeptide binding 1/2103 11/18639 0.0909090909090909 0.805732071067306 0.732130440541579 0.985793106100724 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/2103 83/18639 0.0963855421686747 0.854270147637626 0.732862310237453 0.985793106100724 GO:0019239 deaminase activity 3/2103 33/18639 0.0909090909090909 0.805732071067306 0.735920844631174 0.985793106100724 GO:0043177 organic acid binding 19/2103 189/18639 0.100529100529101 0.890994724090302 0.737473724913574 0.985793106100724 GO:0004722 protein serine/threonine phosphatase activity 10/2103 103/18639 0.0970873786407767 0.860490561334017 0.738702705223084 0.985793106100724 GO:0005253 monoatomic anion channel activity 10/2103 103/18639 0.0970873786407767 0.860490561334017 0.738702705223084 0.985793106100724 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/2103 54/18639 0.0925925925925926 0.820653035346331 0.743768206388984 0.985793106100724 GO:0050661 NADP binding 5/2103 54/18639 0.0925925925925926 0.820653035346331 0.743768206388984 0.985793106100724 GO:0017018 myosin phosphatase activity 8/2103 84/18639 0.0952380952380952 0.844100264927654 0.745073866308256 0.985793106100724 GO:0030547 signaling receptor inhibitor activity 4/2103 44/18639 0.0909090909090909 0.805732071067306 0.746943986991659 0.985793106100724 GO:0016829 lyase activity 20/2103 200/18639 0.1 0.886305278174037 0.7497507455317 0.985793106100724 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 18/2103 181/18639 0.0994475138121547 0.881408563929982 0.749803210059038 0.985793106100724 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2103 23/18639 0.0869565217391304 0.770700241890467 0.750132963999736 0.985793106100724 GO:0005212 structural constituent of eye lens 2/2103 23/18639 0.0869565217391304 0.770700241890467 0.750132963999736 0.985793106100724 GO:0005283 amino acid:sodium symporter activity 2/2103 23/18639 0.0869565217391304 0.770700241890467 0.750132963999736 0.985793106100724 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2103 23/18639 0.0869565217391304 0.770700241890467 0.750132963999736 0.985793106100724 GO:0071617 lysophospholipid acyltransferase activity 2/2103 23/18639 0.0869565217391304 0.770700241890467 0.750132963999736 0.985793106100724 GO:0140102 catalytic activity, acting on a rRNA 2/2103 23/18639 0.0869565217391304 0.770700241890467 0.750132963999736 0.985793106100724 GO:0015035 protein-disulfide reductase activity 3/2103 34/18639 0.0882352941176471 0.782034068977092 0.754471825708344 0.985793106100724 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/2103 34/18639 0.0882352941176471 0.782034068977092 0.754471825708344 0.985793106100724 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/2103 34/18639 0.0882352941176471 0.782034068977092 0.754471825708344 0.985793106100724 GO:0044183 protein folding chaperone 7/2103 75/18639 0.0933333333333333 0.827218259629101 0.756158896140582 0.985793106100724 GO:0000340 RNA 7-methylguanosine cap binding 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0003720 telomerase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0004000 adenosine deaminase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0004126 cytidine deaminase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0004859 phospholipase inhibitor activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0005049 nuclear export signal receptor activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0008504 monoamine transmembrane transporter activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0015368 calcium:monoatomic cation antiporter activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0016801 hydrolase activity, acting on ether bonds 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0016803 ether hydrolase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0097677 STAT family protein binding 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:1990817 poly(A) RNA polymerase activity 1/2103 12/18639 0.0833333333333333 0.738587731811698 0.762371458554305 0.985793106100724 GO:0098631 cell adhesion mediator activity 7/2103 76/18639 0.0921052631578947 0.816333808844508 0.768289594342954 0.985793106100724 GO:0050660 flavin adenine dinucleotide binding 8/2103 86/18639 0.0930232558139535 0.824470026208407 0.768315455483289 0.985793106100724 GO:0008514 organic anion transmembrane transporter activity 27/2103 269/18639 0.100371747211896 0.889600093334535 0.769354431353887 0.985793106100724 GO:0004622 lysophospholipase activity 2/2103 24/18639 0.0833333333333333 0.738587731811698 0.771165492837214 0.985793106100724 GO:0004806 triacylglycerol lipase activity 2/2103 24/18639 0.0833333333333333 0.738587731811698 0.771165492837214 0.985793106100724 GO:0030215 semaphorin receptor binding 2/2103 24/18639 0.0833333333333333 0.738587731811698 0.771165492837214 0.985793106100724 GO:0050699 WW domain binding 2/2103 24/18639 0.0833333333333333 0.738587731811698 0.771165492837214 0.985793106100724 GO:0060229 lipase activator activity 2/2103 24/18639 0.0833333333333333 0.738587731811698 0.771165492837214 0.985793106100724 GO:0061631 ubiquitin conjugating enzyme activity 3/2103 35/18639 0.0857142857142857 0.759690238434889 0.771957471453902 0.985793106100724 GO:0019212 phosphatase inhibitor activity 5/2103 56/18639 0.0892857142857143 0.791343998369676 0.772238493506832 0.985793106100724 GO:0008237 metallopeptidase activity 18/2103 184/18639 0.0978260869565217 0.867037772126775 0.773699135326601 0.985793106100724 GO:0004180 carboxypeptidase activity 4/2103 46/18639 0.0869565217391304 0.770700241890467 0.777878370102982 0.985793106100724 GO:0008081 phosphoric diester hydrolase activity 8/2103 87/18639 0.0919540229885057 0.814993359240494 0.779347421881198 0.985793106100724 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/2103 67/18639 0.0895522388059701 0.793706219260332 0.781828754099844 0.985793106100724 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/2103 57/18639 0.087719298245614 0.777460770328103 0.785536836301624 0.985793106100724 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/2103 36/18639 0.0833333333333333 0.738587731811698 0.788409470060367 0.985793106100724 GO:0016409 palmitoyltransferase activity 3/2103 36/18639 0.0833333333333333 0.738587731811698 0.788409470060367 0.985793106100724 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0003964 RNA-directed DNA polymerase activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0004465 lipoprotein lipase activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0008417 fucosyltransferase activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0009982 pseudouridine synthase activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0019855 calcium channel inhibitor activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0030955 potassium ion binding 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0039706 co-receptor binding 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0061459 L-arginine transmembrane transporter activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0070123 transforming growth factor beta receptor activity, type III 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0070700 BMP receptor binding 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0071837 HMG box domain binding 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0089720 caspase binding 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0140333 glycerophospholipid flippase activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0140666 annealing activity 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:1901338 catecholamine binding 1/2103 13/18639 0.0769230769230769 0.681773290903106 0.789199870142875 0.985793106100724 GO:0001848 complement binding 2/2103 25/18639 0.08 0.70904422253923 0.790635411554776 0.985793106100724 GO:0005537 D-mannose binding 2/2103 25/18639 0.08 0.70904422253923 0.790635411554776 0.985793106100724 GO:0015271 outward rectifier potassium channel activity 2/2103 25/18639 0.08 0.70904422253923 0.790635411554776 0.985793106100724 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/2103 25/18639 0.08 0.70904422253923 0.790635411554776 0.985793106100724 GO:0016874 ligase activity 16/2103 167/18639 0.0958083832335329 0.849154757532012 0.791380820198877 0.985793106100724 GO:0005548 phospholipid transporter activity 6/2103 68/18639 0.0882352941176471 0.782034068977092 0.793745953176307 0.985793106100724 GO:0140223 general transcription initiation factor activity 6/2103 68/18639 0.0882352941176471 0.782034068977092 0.793745953176307 0.985793106100724 GO:0016758 hexosyltransferase activity 19/2103 197/18639 0.0964467005076142 0.854812197223691 0.79837790750369 0.985793106100724 GO:0004620 phospholipase activity 10/2103 109/18639 0.0917431192660551 0.813124108416548 0.799359679456382 0.985793106100724 GO:0022829 wide pore channel activity 3/2103 37/18639 0.0810810810810811 0.718625901222192 0.803862802995425 0.985793106100724 GO:0023023 MHC protein complex binding 3/2103 37/18639 0.0810810810810811 0.718625901222192 0.803862802995425 0.985793106100724 GO:0019865 immunoglobulin binding 2/2103 26/18639 0.0769230769230769 0.681773290903106 0.80862740054733 0.985793106100724 GO:0097602 cullin family protein binding 2/2103 26/18639 0.0769230769230769 0.681773290903106 0.80862740054733 0.985793106100724 GO:0120014 phospholipid transfer activity 2/2103 26/18639 0.0769230769230769 0.681773290903106 0.80862740054733 0.985793106100724 GO:0016298 lipase activity 12/2103 130/18639 0.0923076923076923 0.818127949083727 0.80892635573704 0.985793106100724 GO:0099106 ion channel regulator activity 15/2103 160/18639 0.09375 0.83091119828816 0.812088154798079 0.985793106100724 GO:0004065 arylsulfatase activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0004705 JUN kinase activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0008191 metalloendopeptidase inhibitor activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0008331 high voltage-gated calcium channel activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0015926 glucosidase activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0019763 immunoglobulin receptor activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0031404 chloride ion binding 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0032036 myosin heavy chain binding 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0042043 neurexin family protein binding 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0042813 Wnt receptor activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0043176 amine binding 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0061783 peptidoglycan muralytic activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:1901474 azole transmembrane transporter activity 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:1901612 cardiolipin binding 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:1990825 sequence-specific mRNA binding 1/2103 14/18639 0.0714285714285714 0.633075198695741 0.813000614966752 0.985793106100724 GO:0015108 chloride transmembrane transporter activity 11/2103 121/18639 0.0909090909090909 0.805732071067306 0.816804577996173 0.989436465322175 GO:0015291 secondary active transmembrane transporter activity 28/2103 287/18639 0.0975609756097561 0.864688076267353 0.819806699158915 0.990680416958706 GO:0015252 proton channel activity 2/2103 27/18639 0.0740740740740741 0.656522428277064 0.825226931581277 0.990680416958706 GO:0023026 MHC class II protein complex binding 2/2103 27/18639 0.0740740740740741 0.656522428277064 0.825226931581277 0.990680416958706 GO:0035255 ionotropic glutamate receptor binding 2/2103 27/18639 0.0740740740740741 0.656522428277064 0.825226931581277 0.990680416958706 GO:0000774 adenyl-nucleotide exchange factor activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0004089 carbonate dehydratase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0008242 omega peptidase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0010181 FMN binding 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0017081 chloride channel regulator activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0034483 heparan sulfate sulfotransferase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0045504 dynein heavy chain binding 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0047372 monoacylglycerol lipase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0048531 beta-1,3-galactosyltransferase activity 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0120283 protein serine/threonine kinase binding 1/2103 15/18639 0.0666666666666667 0.590870185449358 0.834115230092922 0.990680416958706 GO:0004175 endopeptidase activity 40/2103 405/18639 0.0987654320987654 0.875363237702753 0.837357863222828 0.990680416958706 GO:0005242 inward rectifier potassium channel activity 2/2103 28/18639 0.0714285714285714 0.633075198695741 0.840519011827976 0.990680416958706 GO:0016866 intramolecular transferase activity 2/2103 28/18639 0.0714285714285714 0.633075198695741 0.840519011827976 0.990680416958706 GO:0046875 ephrin receptor binding 2/2103 28/18639 0.0714285714285714 0.633075198695741 0.840519011827976 0.990680416958706 GO:0050698 proteoglycan sulfotransferase activity 2/2103 28/18639 0.0714285714285714 0.633075198695741 0.840519011827976 0.990680416958706 GO:0005254 chloride channel activity 7/2103 83/18639 0.0843373493975904 0.747486379182923 0.840971868658173 0.990680416958706 GO:0005048 signal sequence binding 4/2103 51/18639 0.0784313725490196 0.695141394646304 0.842126319474604 0.990680416958706 GO:0015036 disulfide oxidoreductase activity 3/2103 40/18639 0.075 0.664728958630528 0.844614036389977 0.990680416958706 GO:0071949 FAD binding 3/2103 40/18639 0.075 0.664728958630528 0.844614036389977 0.990680416958706 GO:0140662 ATP-dependent protein folding chaperone 3/2103 40/18639 0.075 0.664728958630528 0.844614036389977 0.990680416958706 GO:0008194 UDP-glycosyltransferase activity 13/2103 145/18639 0.0896551724137931 0.794618525259482 0.84616701835922 0.990680416958706 GO:0003735 structural constituent of ribosome 16/2103 175/18639 0.0914285714285714 0.810336254330548 0.846538258732947 0.990680416958706 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0008142 oxysterol binding 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0019841 retinol binding 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0022841 potassium ion leak channel activity 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0055102 lipase inhibitor activity 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0070411 I-SMAD binding 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0097027 ubiquitin-protein transferase activator activity 1/2103 16/18639 0.0625 0.553940798858773 0.852846741643319 0.990680416958706 GO:0005416 amino acid:monoatomic cation symporter activity 2/2103 29/18639 0.0689655172413793 0.61124501943037 0.854587201004118 0.990680416958706 GO:0035250 UDP-galactosyltransferase activity 2/2103 29/18639 0.0689655172413793 0.61124501943037 0.854587201004118 0.990680416958706 GO:0015294 solute:monoatomic cation symporter activity 10/2103 116/18639 0.0862068965517241 0.764056274287963 0.856201796780175 0.990680416958706 GO:0008227 G protein-coupled amine receptor activity 3/2103 41/18639 0.0731707317073171 0.648516057200515 0.856462612347159 0.990680416958706 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/2103 41/18639 0.0731707317073171 0.648516057200515 0.856462612347159 0.990680416958706 GO:0005126 cytokine receptor binding 26/2103 275/18639 0.0945454545454545 0.837961353909999 0.856711595871311 0.990680416958706 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/2103 53/18639 0.0754716981132075 0.668909643904934 0.863056403540946 0.990680416958706 GO:0046943 carboxylic acid transmembrane transporter activity 17/2103 188/18639 0.0904255319148936 0.801446262178651 0.864181753538754 0.990680416958706 GO:0016247 channel regulator activity 15/2103 168/18639 0.0892857142857143 0.791343998369676 0.864234636941536 0.990680416958706 GO:0001965 G-protein alpha-subunit binding 2/2103 30/18639 0.0666666666666667 0.590870185449358 0.867512856024765 0.990680416958706 GO:0048019 receptor antagonist activity 2/2103 30/18639 0.0666666666666667 0.590870185449358 0.867512856024765 0.990680416958706 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0004550 nucleoside diphosphate kinase activity 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0008484 sulfuric ester hydrolase activity 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0038191 neuropilin binding 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0045125 bioactive lipid receptor activity 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0070402 NADPH binding 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0070403 NAD+ binding 1/2103 17/18639 0.0588235294117647 0.521356045984728 0.869464005366892 0.990680416958706 GO:0005342 organic acid transmembrane transporter activity 17/2103 189/18639 0.0899470899470899 0.797205805765007 0.869537313090555 0.990680416958706 GO:0160215 deacylase activity 5/2103 65/18639 0.0769230769230769 0.681773290903106 0.871112653688346 0.990680416958706 GO:0017022 myosin binding 6/2103 76/18639 0.0789473684210526 0.699714693295292 0.871712659638159 0.990680416958706 GO:0042277 peptide binding 23/2103 249/18639 0.0923694779116466 0.818675558152725 0.872183306044519 0.990680416958706 GO:0141108 transporter regulator activity 15/2103 170/18639 0.0882352941176471 0.782034068977092 0.875327807046361 0.990680416958706 GO:0008200 ion channel inhibitor activity 3/2103 43/18639 0.0697674418604651 0.618352519656305 0.877804360719555 0.990680416958706 GO:0008375 acetylglucosaminyltransferase activity 3/2103 43/18639 0.0697674418604651 0.618352519656305 0.877804360719555 0.990680416958706 GO:0017147 Wnt-protein binding 2/2103 31/18639 0.0645161290322581 0.571809856886476 0.879374564379502 0.990680416958706 GO:0008374 O-acyltransferase activity 4/2103 55/18639 0.0727272727272727 0.644585656853845 0.881562673525311 0.990680416958706 GO:0046982 protein heterodimerization activity 35/2103 369/18639 0.0948509485094851 0.840668963037705 0.884028962157503 0.990680416958706 GO:0000400 four-way junction DNA binding 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0004970 glutamate-gated receptor activity 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0015280 ligand-gated sodium channel activity 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0017128 phospholipid scramblase activity 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0099602 neurotransmitter receptor regulator activity 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:1990381 ubiquitin-specific protease binding 1/2103 18/18639 0.0555555555555556 0.492391821207798 0.884205558192229 0.990680416958706 GO:0003730 mRNA 3'-UTR binding 24/2103 262/18639 0.0916030534351145 0.811882697564003 0.885797526345434 0.990680416958706 GO:0005262 calcium channel activity 11/2103 131/18639 0.083969465648855 0.744225806100337 0.885910792905458 0.990680416958706 GO:0016248 channel inhibitor activity 3/2103 44/18639 0.0681818181818182 0.60429905330048 0.887379510016718 0.990680416958706 GO:0051082 unfolded protein binding 10/2103 121/18639 0.0826446280991736 0.732483700970279 0.888375329711443 0.990680416958706 GO:0030170 pyridoxal phosphate binding 4/2103 56/18639 0.0714285714285714 0.633075198695741 0.889972225834425 0.990680416958706 GO:0008378 galactosyltransferase activity 2/2103 32/18639 0.0625 0.553940798858773 0.890247733292802 0.990680416958706 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/2103 32/18639 0.0625 0.553940798858773 0.890247733292802 0.990680416958706 GO:0043425 bHLH transcription factor binding 2/2103 32/18639 0.0625 0.553940798858773 0.890247733292802 0.990680416958706 GO:0061135 endopeptidase regulator activity 16/2103 184/18639 0.0869565217391304 0.770700241890467 0.894500832027926 0.990680416958706 GO:0008009 chemokine activity 3/2103 45/18639 0.0666666666666667 0.590870185449358 0.896277769734377 0.990680416958706 GO:0042605 peptide antigen binding 3/2103 45/18639 0.0666666666666667 0.590870185449358 0.896277769734377 0.990680416958706 GO:0141110 transporter inhibitor activity 3/2103 45/18639 0.0666666666666667 0.590870185449358 0.896277769734377 0.990680416958706 GO:0003756 protein disulfide isomerase activity 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0008301 DNA binding, bending 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0008574 plus-end-directed microtubule motor activity 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0016918 retinal binding 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0022840 leak channel activity 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0022842 narrow pore channel activity 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0042834 peptidoglycan binding 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0141147 intracellularly calcium-gated channel activity 1/2103 19/18639 0.0526315789473684 0.466476462196862 0.897283035831547 0.990680416958706 GO:0070279 vitamin B6 binding 4/2103 57/18639 0.0701754385964912 0.621968616262482 0.89785414202558 0.990680416958706 GO:0019956 chemokine binding 2/2103 33/18639 0.0606060606060606 0.537154714044871 0.900204306754843 0.990766311940017 GO:0140311 protein sequestering activity 2/2103 33/18639 0.0606060606060606 0.537154714044871 0.900204306754843 0.990766311940017 GO:0000049 tRNA binding 6/2103 80/18639 0.075 0.664728958630528 0.900390486801396 0.990766311940017 GO:0015103 inorganic anion transmembrane transporter activity 14/2103 165/18639 0.0848484848484849 0.752016599662819 0.901133172249159 0.990766311940017 GO:0052689 carboxylic ester hydrolase activity 7/2103 92/18639 0.0760869565217391 0.674362711654159 0.906290917834111 0.994460231875855 GO:0030971 receptor tyrosine kinase binding 6/2103 81/18639 0.0740740740740741 0.656522428277064 0.906635513584052 0.994460231875855 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/2103 20/18639 0.05 0.443152639087019 0.908884205307716 0.994460231875855 GO:0031418 L-ascorbic acid binding 1/2103 20/18639 0.05 0.443152639087019 0.908884205307716 0.994460231875855 GO:0015293 symporter activity 12/2103 146/18639 0.0821917808219178 0.728470091649894 0.909156313112575 0.994460231875855 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/2103 34/18639 0.0588235294117647 0.521356045984728 0.909312586820249 0.994460231875855 GO:0005343 organic acid:sodium symporter activity 2/2103 35/18639 0.0571428571428571 0.506460158956593 0.917637139266694 0.99906888660985 GO:0016229 steroid dehydrogenase activity 2/2103 35/18639 0.0571428571428571 0.506460158956593 0.917637139266694 0.99906888660985 GO:0030414 peptidase inhibitor activity 14/2103 169/18639 0.0828402366863905 0.734217390203344 0.918093378109328 0.99906888660985 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/2103 60/18639 0.0666666666666667 0.590870185449358 0.918589103891762 0.99906888660985 GO:0008373 sialyltransferase activity 1/2103 21/18639 0.0476190476190476 0.422050132463827 0.919175655774329 0.99906888660985 GO:0015174 basic amino acid transmembrane transporter activity 1/2103 21/18639 0.0476190476190476 0.422050132463827 0.919175655774329 0.99906888660985 GO:0019200 carbohydrate kinase activity 1/2103 21/18639 0.0476190476190476 0.422050132463827 0.919175655774329 0.99906888660985 GO:0004867 serine-type endopeptidase inhibitor activity 7/2103 95/18639 0.0736842105263158 0.653067047075606 0.922226804691319 0.999999992200964 GO:0019842 vitamin binding 12/2103 150/18639 0.08 0.70904422253923 0.925858177710603 0.999999992200964 GO:0004866 endopeptidase inhibitor activity 13/2103 161/18639 0.0807453416149068 0.715650224612577 0.927448816835776 0.999999992200964 GO:0005243 gap junction channel activity 1/2103 22/18639 0.0454545454545455 0.402866035533653 0.928305186116288 0.999999992200964 GO:0031683 G-protein beta/gamma-subunit complex binding 1/2103 22/18639 0.0454545454545455 0.402866035533653 0.928305186116288 0.999999992200964 GO:0031681 G-protein beta-subunit binding 1/2103 23/18639 0.0434782608695652 0.385350120945233 0.936403923485222 0.999999992200964 GO:0043274 phospholipase binding 1/2103 23/18639 0.0434782608695652 0.385350120945233 0.936403923485222 0.999999992200964 GO:0016597 amino acid binding 3/2103 51/18639 0.0588235294117647 0.521356045984728 0.937553769121114 0.999999992200964 GO:0005109 frizzled binding 2/2103 38/18639 0.0526315789473684 0.466476462196862 0.938497846478932 0.999999992200964 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 10/2103 132/18639 0.0757575757575758 0.671443392556089 0.938638402390912 0.999999992200964 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/2103 122/18639 0.0737704918032787 0.653831762587404 0.942040140838112 0.999999992200964 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 9/2103 122/18639 0.0737704918032787 0.653831762587404 0.942040140838112 0.999999992200964 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/2103 24/18639 0.0416666666666667 0.369293865905849 0.943588203078613 0.999999992200964 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/2103 24/18639 0.0416666666666667 0.369293865905849 0.943588203078613 0.999999992200964 GO:0005315 phosphate transmembrane transporter activity 1/2103 24/18639 0.0416666666666667 0.369293865905849 0.943588203078613 0.999999992200964 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2103 24/18639 0.0416666666666667 0.369293865905849 0.943588203078613 0.999999992200964 GO:0030552 cAMP binding 1/2103 24/18639 0.0416666666666667 0.369293865905849 0.943588203078613 0.999999992200964 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/2103 24/18639 0.0416666666666667 0.369293865905849 0.943588203078613 0.999999992200964 GO:0019843 rRNA binding 4/2103 65/18639 0.0615384615384615 0.545418632722484 0.944889481705536 0.999999992200964 GO:0005246 calcium channel regulator activity 3/2103 53/18639 0.0566037735849057 0.5016822329287 0.947516991436808 0.999999992200964 GO:0005544 calcium-dependent phospholipid binding 3/2103 53/18639 0.0566037735849057 0.5016822329287 0.947516991436808 0.999999992200964 GO:0016860 intramolecular oxidoreductase activity 3/2103 53/18639 0.0566037735849057 0.5016822329287 0.947516991436808 0.999999992200964 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2103 25/18639 0.04 0.354522111269615 0.949961236058773 0.999999992200964 GO:0099094 ligand-gated monoatomic cation channel activity 10/2103 136/18639 0.0735294117647059 0.65169505748091 0.951274182895136 0.999999992200964 GO:0042287 MHC protein binding 2/2103 41/18639 0.0487804878048781 0.432344038133677 0.954274277754411 0.999999992200964 GO:0140828 metal cation:monoatomic cation antiporter activity 2/2103 41/18639 0.0487804878048781 0.432344038133677 0.954274277754411 0.999999992200964 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2103 26/18639 0.0384615384615385 0.340886645451553 0.955614589479231 0.999999992200964 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/2103 26/18639 0.0384615384615385 0.340886645451553 0.955614589479231 0.999999992200964 GO:0004950 chemokine receptor activity 1/2103 26/18639 0.0384615384615385 0.340886645451553 0.955614589479231 0.999999992200964 GO:0005227 calcium-activated cation channel activity 1/2103 26/18639 0.0384615384615385 0.340886645451553 0.955614589479231 0.999999992200964 GO:0008066 glutamate receptor activity 1/2103 26/18639 0.0384615384615385 0.340886645451553 0.955614589479231 0.999999992200964 GO:0051139 metal cation:proton antiporter activity 1/2103 26/18639 0.0384615384615385 0.340886645451553 0.955614589479231 0.999999992200964 GO:0170055 lipid transmembrane transporter activity 3/2103 56/18639 0.0535714285714286 0.474806399021806 0.959719677539296 0.999999992200964 GO:0008236 serine-type peptidase activity 15/2103 194/18639 0.077319587628866 0.685287586217039 0.960001617165263 0.999999992200964 GO:0005104 fibroblast growth factor receptor binding 1/2103 27/18639 0.037037037037037 0.328261214138532 0.960629499398383 0.999999992200964 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/2103 27/18639 0.037037037037037 0.328261214138532 0.960629499398383 0.999999992200964 GO:0008083 growth factor activity 12/2103 162/18639 0.0740740740740741 0.656522428277064 0.961173424265989 0.999999992200964 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/2103 70/18639 0.0571428571428571 0.506460158956593 0.963191930752824 0.999999992200964 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/2103 130/18639 0.0692307692307692 0.613595961812795 0.964478963420752 0.999999992200964 GO:0015081 sodium ion transmembrane transporter activity 12/2103 164/18639 0.0731707317073171 0.648516057200515 0.965320587905966 0.999999992200964 GO:0004252 serine-type endopeptidase activity 13/2103 176/18639 0.0738636363636364 0.654657307742187 0.967193010881249 0.999999992200964 GO:0017171 serine hydrolase activity 15/2103 198/18639 0.0757575757575758 0.671443392556089 0.96752621040479 0.999999992200964 GO:0005179 hormone activity 9/2103 132/18639 0.0681818181818182 0.60429905330048 0.968698390824711 0.999999992200964 GO:0022839 monoatomic ion-gated channel activity 1/2103 30/18639 0.0333333333333333 0.295435092724679 0.972524526230898 0.999999992200964 GO:0033612 receptor serine/threonine kinase binding 1/2103 30/18639 0.0333333333333333 0.295435092724679 0.972524526230898 0.999999992200964 GO:0070566 adenylyltransferase activity 1/2103 30/18639 0.0333333333333333 0.295435092724679 0.972524526230898 0.999999992200964 GO:0016757 glycosyltransferase activity 21/2103 267/18639 0.0786516853932584 0.697094039013288 0.974367809805946 0.999999992200964 GO:0003924 GTPase activity 27/2103 331/18639 0.081570996978852 0.722968051682749 0.975498524956589 0.999999992200964 GO:0005184 neuropeptide hormone activity 1/2103 31/18639 0.032258064516129 0.285904928443238 0.975629524959278 0.999999992200964 GO:0160041 neuropeptide activity 1/2103 32/18639 0.03125 0.276970399429387 0.978383776303358 0.999999992200964 GO:0016763 pentosyltransferase activity 2/2103 49/18639 0.0408163265306122 0.361757256397566 0.979619221295499 0.999999992200964 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/2103 33/18639 0.0303030303030303 0.268577357022436 0.980826884726749 0.999999992200964 GO:0015276 ligand-gated monoatomic ion channel activity 13/2103 186/18639 0.0698924731182796 0.619460678293682 0.981473928769563 0.999999992200964 GO:0048020 CCR chemokine receptor binding 2/2103 50/18639 0.04 0.354522111269615 0.981605839277389 0.999999992200964 GO:0046906 tetrapyrrole binding 10/2103 152/18639 0.0657894736842105 0.583095577746077 0.981784596604079 0.999999992200964 GO:0015370 solute:sodium symporter activity 4/2103 79/18639 0.0506329113924051 0.448762166164069 0.982711681677732 0.999999992200964 GO:0022834 ligand-gated channel activity 13/2103 188/18639 0.0691489361702128 0.612870671077792 0.983536726458444 0.999999992200964 GO:0020037 heme binding 9/2103 142/18639 0.0633802816901408 0.561742781941291 0.983735506996424 0.999999992200964 GO:0008146 sulfotransferase activity 2/2103 53/18639 0.0377358490566038 0.334454821952467 0.986501711655504 0.999999992200964 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/2103 36/18639 0.0277777777777778 0.246195910603899 0.986621315620747 0.999999992200964 GO:0005525 GTP binding 30/2103 378/18639 0.0793650793650794 0.703416887439712 0.987711497068537 0.999999992200964 GO:0030280 structural constituent of skin epidermis 1/2103 37/18639 0.027027027027027 0.239541967074064 0.988133726159347 0.999999992200964 GO:0030551 cyclic nucleotide binding 1/2103 37/18639 0.027027027027027 0.239541967074064 0.988133726159347 0.999999992200964 GO:0016782 transferase activity, transferring sulphur-containing groups 3/2103 70/18639 0.0428571428571429 0.379845119217444 0.988875469643936 0.999999992200964 GO:0042379 chemokine receptor binding 3/2103 72/18639 0.0416666666666667 0.369293865905849 0.990797553052242 0.999999992200964 GO:0022832 voltage-gated channel activity 11/2103 175/18639 0.0628571428571429 0.557106174852252 0.991257954813286 0.999999992200964 GO:0071855 neuropeptide receptor binding 1/2103 40/18639 0.025 0.221576319543509 0.991720590075393 0.999999992200964 GO:0019001 guanyl nucleotide binding 31/2103 400/18639 0.0775 0.686886590584879 0.992709121223367 0.999999992200964 GO:0032561 guanyl ribonucleotide binding 31/2103 400/18639 0.0775 0.686886590584879 0.992709121223367 0.999999992200964 GO:0005506 iron ion binding 9/2103 154/18639 0.0584415584415584 0.517970617114697 0.992911649500321 0.999999992200964 GO:0019003 GDP binding 3/2103 75/18639 0.04 0.354522111269615 0.993092506390568 0.999999992200964 GO:0046873 metal ion transmembrane transporter activity 35/2103 450/18639 0.0777777777777778 0.689348549690918 0.994841829360054 0.999999992200964 GO:0016790 thiolester hydrolase activity 1/2103 44/18639 0.0227272727272727 0.201433017766827 0.994876842160584 0.999999992200964 GO:0005244 voltage-gated monoatomic ion channel activity 10/2103 173/18639 0.0578034682080925 0.512315189695975 0.995599967023431 0.999999992200964 GO:0003823 antigen binding 10/2103 174/18639 0.0574712643678161 0.509370849525309 0.995900916377993 0.999999992200964 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2103 46/18639 0.0217391304347826 0.192675060472617 0.99597014848075 0.999999992200964 GO:0099095 ligand-gated monoatomic anion channel activity 1/2103 47/18639 0.0212765957446809 0.188575591100859 0.996425953232268 0.999999992200964 GO:0015079 potassium ion transmembrane transporter activity 8/2103 160/18639 0.05 0.443152639087019 0.998253855318367 0.999999992200964 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/2103 53/18639 0.0188679245283019 0.167227410976233 0.998260899110771 0.999999992200964 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/2103 73/18639 0.0273972602739726 0.242823363883298 0.998375818488344 0.999999992200964 GO:0004497 monooxygenase activity 4/2103 106/18639 0.0377358490566038 0.334454821952467 0.998488413585379 0.999999992200964 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/2103 56/18639 0.0178571428571429 0.158268799673935 0.998786983216361 0.999999992200964 GO:0005216 monoatomic ion channel activity 32/2103 448/18639 0.0714285714285714 0.633075198695741 0.998836483134184 0.999999992200964 GO:0140101 catalytic activity, acting on a tRNA 6/2103 139/18639 0.0431654676258993 0.382577817916851 0.998945568420282 0.999999992200964 GO:0022836 gated channel activity 20/2103 318/18639 0.0628930817610063 0.557424703254111 0.999172475507335 0.999999992200964 GO:0022843 voltage-gated monoatomic cation channel activity 6/2103 143/18639 0.041958041958042 0.371876340492603 0.999254990431822 0.999999992200964 GO:0005249 voltage-gated potassium channel activity 3/2103 98/18639 0.0306122448979592 0.271317942298175 0.999290407217978 0.999999992200964 GO:0001664 G protein-coupled receptor binding 18/2103 297/18639 0.0606060606060606 0.537154714044871 0.999299931618302 0.999999992200964 GO:0022824 transmitter-gated monoatomic ion channel activity 1/2103 63/18639 0.0158730158730159 0.140683377487942 0.999476768563112 0.999999992200964 GO:0022835 transmitter-gated channel activity 1/2103 63/18639 0.0158730158730159 0.140683377487942 0.999476768563112 0.999999992200964 GO:0005125 cytokine activity 12/2103 234/18639 0.0512820512820513 0.454515527268737 0.999677505985331 0.999999992200964 GO:0005267 potassium channel activity 4/2103 124/18639 0.032258064516129 0.285904928443238 0.999731016862303 0.999999992200964 GO:0098960 postsynaptic neurotransmitter receptor activity 1/2103 69/18639 0.0144927536231884 0.128450040315078 0.999745567827646 0.999999992200964 GO:0030594 neurotransmitter receptor activity 2/2103 97/18639 0.0206185567010309 0.182743356324544 0.999882433118476 0.999999992200964 GO:0005261 monoatomic cation channel activity 19/2103 341/18639 0.0557184750733138 0.493835785492865 0.999916757629002 0.999999992200964 GO:0008528 G protein-coupled peptide receptor activity 3/2103 122/18639 0.0245901639344262 0.217943920862468 0.999940576803364 0.999999992200964 GO:0001653 peptide receptor activity 3/2103 128/18639 0.0234375 0.20772779957204 0.999968427141627 0.999999992200964 GO:0045182 translation regulator activity 14/2103 356/18639 0.0393258426966292 0.348547019506644 0.99999984660628 0.999999992200964 GO:0030371 translation repressor activity 10/2103 329/18639 0.0303951367781155 0.269393701572656 0.999999992200964 0.999999992200964