category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	79/692	222/9376	4.82153830130709	RPL13A/RPS8/RPS14/RPS11/RPL28/RPL27A/RPS15/RPL18A/RPL10/RPL7/RPS9/RPS20/RPLP2/RPS26/RPS28/RPL23/RPS4X/RPS12/RPL37A/RPS2/RPL8/RPLP1/RPS16/RPL13/UBA52/RPS27A/RPL29/RPL19/RPL18/RPS5/RPS24/RPS3/RPL15/RPL11/RPL35/RPS19/RPL31/RPL3/RPL21/RPL36/RPL37/RPL6/RPL5/RPS18/RACK1/RPL34/RPS6/RPS27/RPS17/RPS3A/RPL39/MRPS26/RPL9/RPL35A/MRPL34/MRPL1/RPS23/MRPS14/RPL10A/MRPS18B/MRPL24/MRPL2/RPSA/RPL22/MRPL15/RPL32/MRPL14/RPL4/RPS29/MRPL51/MRPL48/MRPS7/MRPS24/RPL7A/MRPS33/MRPL36/MRPL54/MRPS25/MRPL43	16.2662719136587
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	75/692	238/9376	4.26968475251372	RPL13A/RPS8/RPS14/RPS11/RPL28/RPL27A/RPS15/RPL18A/RPL10/RPL7/RPS9/RPS20/RPLP2/RPS26/RPS28/C1QA/RPL23/RPS4X/RPS12/RPL37A/RPS2/F13A1/RPL8/RPLP1/RPS16/RPL13/C1QB/UBA52/CFD/RPS27A/RPL29/RPL19/RPL18/RPS5/RPS24/RPS3/RPL15/RPL11/RPL35/RPS19/RPL31/RPL3/RPL21/RPL36/RPL37/RPL6/RPL5/C5AR1/RPS18/RPL34/RPS6/RPS27/RPS17/CYBB/RPS3A/RPL39/RPL9/RPL35A/RPS23/RPL10A/RPSA/RPL22/TYK2/MAPK3/RPL32/IKBKG/RPL4/IRAK1/RPS29/FCGR2A/RPL7A/TLR3/C2/JAK1/SYK	14.4227329347312
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	54/692	275/9376	2.6605570152391	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/C1QA/ATP5F1E/C1QB/CYBA/COX4I1/MT-ND6/CYBB/UQCRB/PSMD12/PSMC2/UQCRFS1/CREB1/CYC1/NDUFC1/NCF1/SLC25A6/CCL5/PSMB3/CREB3/NDUFA10/SLC25A5/GSK3B/PSMD6/PSMB5/MAPK3/PSMD3/PSMD13/ATP5F1B/MT-ATP8/ATP5MC3/PSMC4/NDUFA6/COX4I2/UQCRH/NDUFS3/ADRM1/NDUFA8/ATP5F1D/KIF5B/ATP5PD/PRKACA/TUBA1C/ITPR2/PSMB4	7.88958863281826
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	58/692	308/9376	2.55146010059305	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/COX4I1/MT-ND6/MAP2K7/UQCRB/DCTN4/NRBF2/PSMD12/PSMC2/UQCRFS1/HDAC2/CREB1/CYC1/NDUFC1/SLC25A6/POLR2J/PSMB3/CREB3/NDUFA10/SLC25A5/PSMD6/PSMB5/POLR2F/PSMD3/POLR2E/PSMD13/ATP5F1B/GPX3/MT-ATP8/ATP5MC3/PSMC4/NDUFA6/AP2S1/COX4I2/UQCRH/NDUFS3/GPX7/GNAQ/AP2A2/TP53/ADRM1/NDUFA8/ATP5F1D/KIF5B/ATP5PD/TUBA1C/CLTC/PSMB4	7.81518011780773
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	53/692	268/9376	2.6794927098611	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/UBA52/RPS27A/COX4I1/MT-ND6/UQCRB/UBB/PSMD12/PSMC2/UQCRFS1/CYC1/UBE2G2/NDUFC1/SLC25A6/PINK1/PSMB3/NDUFA10/SLC25A5/PSMD6/PSMB5/PSMD3/PSMD13/ATP5F1B/SLC39A7/MT-ATP8/ATP5MC3/PSMC4/NDUFA6/COX4I2/UQCRH/NDUFS3/TP53/ADRM1/NDUFA8/ATP5F1D/KIF5B/DRD1/CALM3/ATP5PD/PRKACA/TUBA1C/ITPR2/PSMB4	7.87431505505581
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	44/692	205/9376	2.90810658395601	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/CTSD/COL1A1/CYBA/COX4I1/MT-ND6/GAPDH/CYBB/UQCRB/COL1A2/UQCRFS1/MMP2/CYC1/NDUFC1/NCF1/PDHA1/SLC25A6/PPP1CC/TGFB1/NDUFA10/SLC25A5/GSK3B/ATP5F1B/MT-ATP8/ATP5MC3/NDUFA6/COX4I2/COL3A1/UQCRH/NDUFS3/PRKCZ/NDUFA8/ATP5F1D/ATP5PD	7.79740319929362
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	46/692	235/9376	2.65217070471037	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/COX4I1/MT-ND6/ATP5ME/RPS6/UQCRB/NDUFAF2/COX17/UQCRFS1/CREB1/SMARCD2/CYC1/COX20/NDUFC1/CREB3/NDUFA10/PRKAG1/COX19/ATP5F1B/COX14/MAP2K3/SMARCC2/MT-ATP8/ATP5MC3/NDUFA6/HRAS/COX4I2/UQCRH/NDUFS3/ACSL3/CPT1A/AKT1S1/NDUFA8/ATP5F1D/ATP5PD/PRKACA	7.24053691286701
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/692	138/9376	3.24001005277708	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/COX4I1/MT-ND6/ATP5ME/UQCRB/ATP6V1C1/COX17/UQCRFS1/ATP6V1B2/CYC1/NDUFC1/NDUFA10/ATP5F1B/MT-ATP8/TCIRG1/ATP5MC3/NDUFA6/COX4I2/UQCRH/NDUFS3/NDUFA8/ATP5F1D/ATP5PD	7.48306141636051
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/692	227/9376	2.56657584477095	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/HGF/ATP5F1E/CYBA/COX4I1/MT-ND6/MAP2K7/UQCRB/UQCRFS1/CYC1/NDUFC1/NCF1/SLC25A6/MAP2K2/NDUFA10/SLC25A5/MAPK3/ATP5F1B/IKBKG/MT-ATP8/PTPN1/ATP5MC3/NDUFA6/SRC/HRAS/COX4I2/UQCRH/NDUFS3/PRKD2/NDUFA8/ATP5F1D/GSTO1/ATP5PD/CYP1B1	6.74460187068934
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	60/692	388/9376	2.09522674453251	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/APOE/ATP5F1E/COX4I1/MT-ND6/GAPDH/MAP2K7/CYBB/UQCRB/NRBF2/PSMD12/PSMC2/UQCRFS1/CYC1/PSENEN/NDUFC1/SLC25A6/PSMB3/MAP2K2/NDUFA10/SLC25A5/GSK3B/PSMD6/PSMB5/MAPK3/PSMD3/PSMD13/ATP5F1B/IKBKG/SLC39A7/MT-ATP8/ATP5MC3/PSMC4/NDUFA6/HRAS/COX4I2/UQCRH/NDUFS3/BACE1/GNAQ/ADRM1/NDUFA8/ATP5F1D/APH1A/KIF5B/CALM3/ATP5PD/TUBA1C/ITPR2/LRP6/PSMB4	6.21966723020199
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/692	368/9376	2.02500628298567	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/COX4I1/MT-ND6/TNFRSF1B/UQCRB/DCTN4/NRBF2/PSMD12/PSMC2/UQCRFS1/CYC1/RAE1/NDUFC1/PINK1/PSMB3/NDUFA10/PSMD6/PSMB5/PSMD3/MAP1LC3A/PSMD13/VCP/ATP5F1B/PFN2/MAP2K3/GPX3/MT-ATP8/ATP5MC3/PSMC4/NDUFA6/COX4I2/UQCRH/NDUFS3/GPX7/TP53/PFN1/NUP37/ADRM1/NDUFA8/ATP5F1D/SIGMAR1/KIF5B/ATP5PD/TUBA1C/PSMB4	5.66258880641056
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	66/692	480/9376	1.86300578034682	MT-CO3/MT-CYB/MT-ND1/MT-CO2/MT-ATP6/MT-ND4/MT-CO1/MT-ND2/MT-ND5/MT-ND3/ATP5F1E/UBA52/RPS27A/COX4I1/MT-ND6/TNFRSF1B/MAP2K7/CYBB/UQCRB/DCTN4/NRBF2/UBB/PSMD12/PSMC2/UQCRFS1/CYC1/UBE2G2/NDUFC1/SLC25A6/PINK1/PSMB3/MAP2K2/NDUFA10/SLC25A5/GSK3B/PSMD6/PSMB5/MAPK3/PSMD3/MAP1LC3A/PSMD13/VCP/ATP5F1B/MAP2K3/GPX3/MT-ATP8/ATP5MC3/PSMC4/NDUFA6/HRAS/COX4I2/UQCRH/NDUFS3/GPX7/GNAQ/ADRM1/NDUFA8/ATP5F1D/SIGMAR1/KIF5B/CALM3/ATP5PD/TUBA1C/ITPR2/LRP6/PSMB4	5.47918184514274
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/692	78/9376	3.30042982066103	HLA-DRA/CYBA/HLA-DRB5/HLA-DRB1/CYBB/HLA-DPB1/ITGB2/HLA-DPA1/NCF1/TGFB1/MAPK3/PTPN6/IRAK1/FCGR2A/HLA-DMB/EEF1A1/HLA-DQA1/JAK1/HLA-DQB1	5.75891007649596
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/692	181/9376	2.39542681953182	CD74/CD14/FCER1G/HLA-DRA/CTSD/HLA-DRB5/MRC1/CTSS/TRADD/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DPA1/CREB1/RIPK2/NFYC/TGFB1/MAPK3/CORO1A/IRAK1/TCIRG1/SRC/FCGR2A/HLA-DMB/SPHK2/CD209/RAB7A/HLA-DQA1/JAK1/SYK/CALM3/HLA-DQB1	5.35117636015621
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/692	82/9376	3.13943324404342	CD74/HLA-DRA/HLA-DRB5/HLA-A/CTSS/HLA-DRB1/CTSB/HLA-DPB1/HLA-DPA1/CREB1/TAPBP/NFYC/CD4/HSPA4/HSP90AB1/HLA-DMB/IFI30/HLA-DQA1/HLA-DQB1	5.49266497514001
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/692	250/9376	2.11366473988439	PSAP/CTSD/CD63/LAPTM5/CTSC/CTSS/CTSZ/CD68/CTSB/GGA2/ATP6V1C1/ATP6V1B2/NPC2/SLC11A1/GNPTG/TFE3/SLC17A5/VPS16/VPS39/SLC15A3/HEXA/TCIRG1/BORCS7/CTSF/AP2S1/PPT1/CLN8/TLR3/VPS35/AP3S2/RAB7A/TELO2/AP2A2/AKT1S1/AP1S1/ACP5/ABCA2/GGA3/CLTC	5.03805633808419
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/692	46/9376	3.82910278964564	PSMF1/PSMD12/PSMC2/PSMB9/PSMB3/PSMD6/PSMB5/PSMD3/PSMD13/PSMB8/PSMC4/ADRM1/PSMB4	5.42957202988599
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/692	95/9376	2.56720413751141	HLA-DRA/HLA-DRB5/CCL3/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DPA1/ATP6V1C1/ATP6V1B2/CCL5/TGFB1/TCIRG1/HLA-DMB/ITGAL/LTB/HLA-DQA1/ACP5/HLA-DQB1	4.3337989886628
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	30/692	205/9376	1.98279994360637	HLA-DRA/HLA-DRB5/HLA-A/MAP2K7/TRADD/HLA-DRB1/HLA-DPB1/HLA-DPA1/PSMD12/PSMC2/HDAC2/TAPBP/PSMD6/TYK2/PSMD3/PSMD13/MAP2K3/IKBKG/IRAK1/PSMC4/HLA-DMB/ITGAL/CIR1/TP53/ADRM1/HLA-DQA1/JAK1/SYK/CDK4/HLA-DQB1	4.01617367131237
Human Diseases	Immune disease	hsa05310	Asthma	9/692	32/9376	3.8106936416185	FCER1G/HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DMB/HLA-DQA1/HLA-DQB1	4.49573665198798
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/692	155/9376	2.09793026291255	CD14/HLA-DRA/CYBA/HLA-DRB5/HLA-A/MRC1/CTSS/HLA-DRB1/CYBB/HLA-DPB1/ITGB2/HLA-DPA1/ATP6V1C1/ATP6V1B2/NCF1/CORO1A/TCIRG1/FCGR2A/HLA-DMB/CD209/RAB7A/HLA-DQA1/HLA-DQB1/TUBA1C	3.89072353542768
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	31/692	224/9376	1.87510322047894	HLA-DRA/HLA-DRB5/HLA-A/SPI1/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DPA1/CREB1/SLC25A6/TGFB1/KAT5/CDC27/MAP2K2/CREB3/SLC25A5/MAPK3/CD4/IKBKG/HRAS/LTBR/HLA-DMB/ITGAL/TP53/TLN1/HLA-DQA1/ANAPC13/JAK1/CDK4/HLA-DQB1/PRKACA	3.74200241611489
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/692	180/9376	1.95709698137444	CD74/HLA-DRA/HLA-DRB5/HLA-A/TRADD/HLA-DRB1/EIF2B4/HLA-DPB1/HLA-DPA1/POU2F2/TAPBP/EIF2B5/PPP1CC/CCL5/TYK2/IKBKG/IRAK1/SRC/HLA-DMB/HCFC2/TLR3/TP53/HLA-DQA1/JAK1/SYK/HLA-DQB1	3.65991918481644
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/692	99/9376	2.32661878904653	C1QA/C1QB/CFD/HLA-DRA/HLA-DRB5/C5AR1/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DPA1/FPR1/FCGR2A/HLA-DMB/ITGAL/HLA-DQA1/C2/HLA-DQB1	3.7457495930139
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/692	50/9376	2.98080924855491	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/TGFB1/CXCR4/LTBR/HLA-DMB/HLA-DQA1/HLA-DQB1	3.96422895888526
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/692	250/9376	1.73428901734104	DAB2/FOLR2/HLA-A/ARPC1B/CYTH4/VTA1/SH3GL1/WIPF1/CHMP1A/RAB4A/WIPF2/SNX2/SNX5/SPG21/PIP5K1C/CXCR4/SRC/HRAS/NEDD4L/AP2S1/GIT1/WWP1/PRKCZ/RAB11B/VPS35/EHD4/RAB7A/SNF8/AP2A2/RUFY1/KIF5B/CLTC	3.32181607741722
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/692	70/9376	2.51626754748142	HLA-DRA/HLA-DRB5/HLA-A/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DPA1/HLA-DMB/DAG1/ITGAL/HLA-DQA1/SNTA1/HLA-DQB1	3.59436448007793
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/692	39/9376	3.12672298799466	HLA-DRA/HLA-DRB5/HLA-A/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DMB/HLA-DQA1/HLA-DQB1	3.75680218293175
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/692	248/9376	1.69364161849711	CD14/RPS3/MYL9/GAPDH/MAP2K7/TRADD/ARPC1B/DCTN4/CYTH4/PTPRC/PKN1/RIPK2/NCKAP1L/MAP2K2/VPS16/MAPK3/VPS39/PFN2/MAP2K3/IKBKG/IRAK1/HSP90AB1/TCF7/HRAS/ANXA2/TCF7L1/EXOC7/RAB7A/PFN1/KIF5B/TUBA1C	3.12501384420719
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	20/692	142/9376	1.9083285842221	TYROBP/CSF1R/CYBA/MAP2K7/SPI1/CREB1/NCF1/TGFB1/TYK2/MAPK3/IKBKG/LILRB3/FCGR2A/LILRB5/JAK1/SYK/ACP5/LILRB2/ITPR2/LILRB1	3.07872569520482
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/692	173/9376	1.80132981389288	HLA-DRA/HLA-DRB5/TRADD/HLA-DRB1/HNRNPUL1/HLA-DPB1/HLA-DPA1/RAE1/SLC25A6/CCL5/MAP2K2/SLC25A5/TYK2/MAPK3/IKBKG/HLA-DMB/TLR3/RAB11B/HLA-DQA1/KPNA6/JAK1/CDK4/HLA-DQB1	3.00295220334687
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/692	44/9376	2.77141355754073	HLA-DRA/HLA-DRB5/HLA-A/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DMB/HLA-DQA1/HLA-DQB1	3.32458710036495
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/692	45/9376	2.70982658959538	HLA-DRA/HLA-DRB5/HLA-A/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DMB/HLA-DQA1/HLA-DQB1	3.24543568224242
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/692	196/9376	1.72820573316032	UBA52/RPS27A/HLA-A/MAP2K7/TRADD/UBB/CREB1/MAP2K2/ATG3/GSK3B/TYK2/MAPK3/MAP1LC3A/IKBKG/TCF7/SRC/HRAS/TCF7L1/TLR3/TP53/JAK1/SYK/CDK4/CALM3/ITPR2	2.90830243507955
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/692	54/9376	2.50909869406979	HLA-DRA/HLA-DRB5/HLA-A/HLA-DRB1/HLA-DPB1/HLA-DPA1/CGA/HLA-DMB/HLA-DQA1/HLA-DQB1	3.13934287900368
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/692	63/9376	2.36572162583723	RPA2/ERCC1/POLR2J/POLR2F/POLR2E/CETN2/RFC1/XPA/RFC2/RBX1/XPC	3.07019837637916
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/692	169/9376	1.76379245476622	UBA52/RPS27A/CTSD/GABARAP/CTSB/NRBF2/UBB/MAP2K2/ATG3/VPS16/MAPK3/VPS39/MAP1LC3A/ATG4D/HRAS/ATG7/RAB7A/IGBP1/AKT1S1/YKT6/EIF2AK4/PRKACA	2.82838433074346
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/692	41/9376	2.64373325814183	MMP2/MAP2K2/MAPK3/SRC/HRAS/RPS6KA5/TP53/CDK4	2.97745281467243
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/692	144/9376	1.78773281952473	C1QA/CD14/C1QB/C5AR1/MAP2K7/TRADD/ALDH2/PRKAG1/GSK3B/MAP2K3/IKBKG/IRAK1/TCF7/TCF7L1/ACOX1/CPT1A/C2/SCD5/ADH5	2.68900163416207
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/692	105/9376	1.93559042113955	UBA52/RPS27A/GABARAP/UBB/TBC1D17/TFE3/PINK1/RHOT2/MAP1LC3A/VCP/TOMM70/SRC/HRAS/RAB7A/TP53	2.72142207800389
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/692	42/9376	2.58078722818607	FTL/FTH1/SLC40A1/CYBB/MAP1LC3A/ATG7/ACSL3/TP53	2.89829737428489
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/692	87/9376	2.02458308418045	MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX4I1/UQCRB/TPM1/UQCRFS1/CYC1/SLC9A1/TNNT2/COX4I2/UQCRH	2.71019852337882
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/692	138/9376	1.76727821060568	MAP2K7/FYB1/ARPC1B/PKN1/WIPF1/WIPF2/MAP2K2/GSK3B/MAPK3/MAP2K3/CD4/IKBKG/IRAK1/PIP5K1C/SRC/FCGR2A/GNAQ/WAS	2.56319830631085
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/692	70/9376	2.12914946325351	HGF/ELOB/TFE3/TGFB1/MAP2K2/MAPK3/GAB1/HRAS/RAPGEF1/PAK2/RBX1	2.67668771923459
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/692	109/9376	1.86455957999682	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/TGFB1/TYK2/MAPK3/CD4/IKBKG/HSP90AB1/HLA-DMB/HLA-DQA1/JAK1/HLA-DQB1	2.56281568305204
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/692	112/9376	1.81461601981833	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/TGFB1/TYK2/MAPK3/MAP2K3/IKBKG/IRAK1/HLA-DMB/HLA-DQA1/JAK1/HLA-DQB1	2.44816938476618
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/692	93/9376	1.89396482068494	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/TYK2/MAPK3/CD4/IKBKG/HLA-DMB/HLA-DQA1/JAK1/HLA-DQB1	2.44566239530089
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/692	22/9376	3.07934839726747	AOC1/ALDH2/CNDP2/HNMT/ALDH3B1	2.75625057644645
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/692	116/9376	1.7520430536177	GAPDH/SUCLG1/ACO2/GCSH/PDHA1/TALDO1/PFKL/ACOX1/PCCB/ME2/PFKM/PC/PRPS1/ADH5/H6PD	2.30062049029865
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/692	106/9376	1.78950812520449	FOLR2/GSTP1/CREB1/SLC46A1/MAP2K2/CREB3/GSK3B/MAPK3/IKBKG/HSP90AB1/TCF7/HRAS/TCF7L1/TP53	2.30753579964841
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/692	31/9376	2.62241282864069	TALDO1/PFKL/PFKM/PGM1/PRPS1/H6PD	2.55406146019432
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/692	138/9376	1.66909608779425	RPS6/PPP1CC/MAP2K2/PTPRF/PRKAG1/GSK3B/MAPK3/PTPN1/HRAS/RAPGEF1/PRKAR2A/EIF4E2/EXOC7/PRKCZ/INPPL1/CALM3/PRKACA	2.23520743230754
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/692	68/9376	1.99251955117307	CD14/CSF1R/SPI1/JUP/MAP2K2/MAPK3/IKBKG/TCF7/HRAS/TCF7L1	2.31869762706064
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/692	88/9376	1.84760903836048	C1QA/F13A1/C1QB/CFD/C5AR1/ITGB2/VSIG4/SERPINA1/CD59/A2M/PLAUR/C2	2.25504176558838
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/692	50/9376	2.1678612716763	HBB/HBA2/HGF/HBA1/PECAM1/ITGB2/TGFB1/ITGAL	2.33726164016919
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/692	109/9376	1.74025560799703	SPP1/CD14/CCL4/CCL3/MAP2K7/CCL5/MAP2K2/TYK2/MAPK3/MAP2K3/IKBKG/IRAK1/TLR3/JAK1	2.19434117154655
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/692	100/9376	1.76138728323699	CD14/HLA-DRA/CSF1R/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/CD37/CD59/CD4/HLA-DMB/HLA-DQA1/HLA-DQB1	2.16074753868061
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/692	91/9376	1.78669885028267	MAP2K2/GSK3B/MAPK3/PTPN6/IKBKG/LILRB3/HRAS/INPPL1/LILRB5/SYK/LILRB2/LILRB1	2.12871262375296
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/692	34/9376	2.39102346140768	POLR2J/POLR2F/POLR2E/POLR3GL/POLR1E/POLR3K	2.29367964273095
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/692	43/9376	2.20567280548461	ALDH2/ECI1/ACAA2/ACOX1/ACSL3/CPT1A/ADH5	2.23682412549946
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/692	93/9376	1.74827521909379	MAP2K7/CGA/MMP2/MAP2K2/MAPK3/MAP2K3/SRC/HRAS/GNAQ/CALM3/PRKACA/ITPR2	2.04709237134307
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/692	44/9376	2.15554387808723	DCTN4/CREB1/CREB3/ARHGDIB/STX4/RAB11B/PRKACA	2.16872353417458
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	18/692	157/9376	1.55340377747506	MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX4I1/UQCRB/UQCRFS1/CYC1/NDUFC1/TGFB1/NDUFA10/PRKAG1/GSK3B/NDUFA6/COX4I2/UQCRH/NDUFS3/NDUFA8	1.97391667582288
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	15/692	125/9376	1.62589595375723	FCER1G/CTSD/TRADD/ORMDL3/S1PR2/ORMDL1/MAP2K2/PPP2R1A/MAPK3/HRAS/SPHK2/PRKCZ/GNAQ/ORMDL2/TP53	1.98857322702014
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/692	214/9376	1.45621522338069	HLA-A/TNFRSF1B/MAP2K7/TRADD/FBXW11/ELOB/CFL1/TAPBP/MAP2K2/MAPK3/MAP2K3/CD4/IKBKG/IRAK1/CXCR4/HRAS/GNAQ/PAK2/RBX1/APOBEC3A/AP1S1/CALM3/ITPR2	1.9057252757462
Organismal Systems	Immune system	hsa04611	Platelet activation	15/692	126/9376	1.6129920176163	FCER1G/COL1A1/COL1A2/PPP1CC/MAPK3/SRC/FCGR2A/COL3A1/PRKCZ/GNAQ/TLN1/SYK/VASP/PRKACA/ITPR2	1.9554557979362
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/692	137/9376	1.58238049027467	CTSD/CTSC/CTSS/TRADD/CTSZ/CTSB/MAP2K2/MAPK3/IKBKG/HRAS/CTSF/PARP2/CASP2/TP53/TUBA1C/ITPR2	1.93835534323891
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/692	204/9376	1.46118100419359	HGF/COL1A1/CD63/RPS6/COL1A2/MMP2/PPP1CC/SLC9A1/TGFB1/MAP2K2/MAPK3/PTPN6/GPC1/PTCH1/GAB1/SRC/HRAS/PLAUR/PPP1R12C/TP53/PRKACA/ITPR2	1.87989351342389
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/692	117/9376	1.62126377155279	BCL7A/HDAC2/CHRAC1/SMARCD2/BAZ2A/KAT5/BRD9/SMARCC2/ACTR6/RBBP4/MBD3/DMAP1/MCRS1/PHF6	1.9088231600209
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/692	37/9376	2.19715669426652	MAP2K2/MAPK3/TCF7/HRAS/TCF7L1/TP53	2.05958846449045
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/692	66/9376	1.84760903836048	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/TGFB1/HLA-DMB/HLA-DQA1/HLA-DQB1	1.95061466248121
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/692	98/9376	1.6590775038339	ARPC1B/PTPRC/CFL1/NCF1/MAPK3/PIP5K1C/FCGR2A/SPHK2/INPPL1/SYK/WAS/VASP	1.85140366875317
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/692	57/9376	1.9016326944529	HACD3/ACAA2/HACD4/ACOX1/PPT1/ACSL3/CPT1A/SCD5	1.92735272166459
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/692	67/9376	1.8200327840566	GAPDH/ALDH2/PDHA1/PFKL/PFKM/PGM1/GALM/ALDH3B1/ADH5	1.90149802912269
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/692	142/9376	1.52666286737768	CYBA/MAP2K7/GSTP1/PECAM1/MEF2C/MMP2/NCF1/GPC1/IKBKG/HSP90AB1/SRC/PRKCZ/SUMO3/TP53/GSTO1/CALM3	1.78509245516536
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/692	110/9376	1.60126116657909	GAPDH/RPS6/TIMP1/CYBB/ELOB/PDHA1/MAP2K2/MAPK3/PFKL/LTBR/EIF4E2/RBX1/PFKM	1.790573397177
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	16/692	144/9376	1.50545921644188	NRBF2/PSMD12/PSMC2/SLC25A6/KAT5/PSMB3/SLC25A5/PSMD6/PSMB5/PSMD3/PSMD13/PSMC4/GNAQ/ADRM1/ITPR2/PSMB4	1.72543358017574
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/692	59/9376	1.8371705692172	CANT1/NUDT2/ENPP1/UCK1/NME3/ASMTL/ENTPD6/NME2	1.82087732765498
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/692	80/9376	1.69364161849711	HGF/RPS6/MAP2K2/GSK3B/MAPK3/GAB1/SRC/HRAS/EIF4E2/JAK1	1.75877732126425
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/692	31/9376	2.18534402386724	ACO2/GCSH/HYI/GRHPR/PCCB	1.86601180352319
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/692	31/9376	2.18534402386724	SEC62/SGTA/SPCS1/SEC11A/UBL4A	1.86601180352319
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/692	160/9376	1.43959537572254	HLA-DRA/HLA-DRB5/HLA-A/PECAM1/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DPA1/PTPRC/PTPRF/CD4/HLA-DMB/SDC3/SIGLEC1/ITGAL/HLA-DQA1/HLA-DQB1	1.58314484667309
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/692	32/9376	2.11705202312139	PFKL/GALT/PFKM/PGM1/GALM	1.7867374971654
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/692	32/9376	2.11705202312139	GABARAP/ATG3/ATG4D/ATG7/IGBP1	1.7867374971654
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/692	107/9376	1.51952892874507	CREB1/PDHA1/CREB3/PRKAG1/PFKL/PRMT1/GNAQ/PFKM/CPT1A/CALM3/PRKACA/ITPR2	1.52568178422393
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	14/692	130/9376	1.45913739439751	COL1A1/MAP2K7/COL1A2/CREB1/MMP2/TGFB1/MAP2K2/CREB3/MAPK3/SRC/HRAS/COL3A1/PRKCZ/PRKACA	1.48804537689191
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/692	142/9376	1.43124643816657	UBA52/RPS27A/FBXW11/ELOB/UBB/PIAS1/UBE2G2/SAE1/FZR1/CDC27/NEDD4L/WWP1/RBX1/ANAPC13/UBE2K	1.4616841451555
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/692	212/9376	1.34213109390337	HGF/CSF1R/FYB1/ITGB2/RALGDS/MAP2K2/MAPK3/PFN2/MAP2K3/FPR1/SRC/HRAS/RAPGEF1/ITGAL/PRKD2/PRKCZ/GNAQ/TLN1/PFN1/VASP/CALM3	1.42231802609566
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/692	44/9376	1.84760903836048	MGAT1/HEXA/MAN1B1/ALG11/ALG12/MAN1A2	1.5907917510794
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/692	154/9376	1.40770212446513	MYL9/MYL6/MEF2C/EEF2/PPP1CC/MAP2K2/PRKAG1/MAPK3/SRC/HRAS/PPP1R12C/GNAQ/CALM3/PRKACA/KCNJ12/ITPR2	1.44002341552351
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/692	65/9376	1.66758559359715	SPP1/CGA/MAP2K2/MAPK3/HRAS/GNAQ/ITPR2/KISS1	1.52455904573887
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/692	120/9376	1.46782273603083	MAP2K7/RIPK2/MAP2K2/GSK3B/MAPK3/ARHGDIB/IRAK1/GAB1/HRAS/RAPGEF1/RPS6KA5/TP53/CALM3	1.45592516487482
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/692	227/9376	1.31313182755723	CCL4/HLA-A/CCL3/TRADD/CREB1/TAPBP/CCL5/MAP2K2/CREB3/GSK3B/MAPK3/IKBKG/CXCR4/SRC/HRAS/GNAQ/TP53/JAK1/CDK4/CALM3/PRKACA/ITPR2	1.34813103174309
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/692	157/9376	1.38080335775561	C1QA/C1QB/STAB1/PECAM1/UQCRFS1/CREB1/TGFB1/MAP2K2/VPS16/MAPK3/VPS39/PTPN6/DNMT3A/SPHK2/RAB7A/CPT1A	1.35827424509587
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/692	157/9376	1.38080335775561	HLA-A/FBXW11/SLC25A6/PPP1CC/TGFB1/MAP2K2/SLC25A5/MAPK3/MAP2K3/HRAS/RBBP4/TP53/CDK4/CALM3/LIN52/ITPR2	1.35827424509587
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/692	67/9376	1.61780691916142	PPP1CC/MAP2K2/MAPK3/HRAS/GNAQ/CALM3/PRKACA/ITPR2	1.43257521163047
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/692	78/9376	1.56336149399733	CNOT7/LSM4/PFKL/PABPC4/EXOSC5/PFKM/XRN2/EDC3/EXOSC8	1.41032260812842
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/692	78/9376	1.56336149399733	C1QA/CD14/C1QB/ITGB2/CFL1/MAPK3/IRAK1/C2/CALM3	1.41032260812842
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	24/692	253/9376	1.28529324407686	CD14/UBA52/RPS27A/MYL9/TRADD/ARPC1B/FBXW11/CYTH4/UBB/RIPK2/CCL5/GSK3B/MAPK3/MAP1LC3A/PFN2/IKBKG/SRC/RPS6KA5/RBX1/TP53/TLN1/PFN1/AKT1S1/ITPR2	1.29855900607562
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/692	101/9376	1.47564814284897	CREB1/MAP2K2/CREB3/GSK3B/MAPK3/TCF7/HRAS/TCF7L1/GNAQ/CALM3/PRKACA	1.35665153698656
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/692	47/9376	1.72967654655024	ALDH2/PDHA1/GRHPR/ME2/PC/ADH5	1.4155999797077
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/692	37/9376	1.83096391188877	PMM1/GALT/CMAS/NAGK/PGM1	1.42959037486946
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/692	27/9376	2.00727895525583	HACD3/HACD4/ACOX1/SCD5	1.47954384865755
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/692	69/9376	1.57091396498283	FCER1G/MAP2K7/ALOX5AP/MAP2K2/MAPK3/MAP2K3/HRAS/SYK	1.34359733190114
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/692	149/9376	1.36400667261512	MT-ND1/MT-ND4/MT-ND2/MT-ND5/MT-ND3/MT-ND6/NDUFC1/NDUFA10/MAPK3/NDUFA6/NDUFS3/GNAQ/NDUFA8/PRKACA/ITPR2	1.26430250005913
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/692	48/9376	1.69364161849711	ALDH2/ACAA2/HMGCL/IVD/PCCB/DBT	1.36000426690356
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/692	59/9376	1.60752424806505	GSTP1/TXNDC12/GPX3/LANCL1/GPX7/SMS/GSTO1	1.3213879823041
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/692	59/9376	1.60752424806505	MAP2K2/GSK3B/MAPK3/TCF7/HRAS/TCF7L1/TP53	1.3213879823041
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/692	139/9376	1.3646608724581	CTSD/CREB1/MMP2/EBAG9/MAP2K2/CREB3/MAPK3/HSP90AB1/SRC/HRAS/GNAQ/CALM3/PRKACA/ITPR2	1.2226717363702
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/692	38/9376	1.78278065104959	PMM1/HEXA/GALT/NAGK/PGM1	1.36484622749929
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/692	93/9376	1.45689601591149	MYL9/LMO7/PTPRF/MAPK3/PTPN6/PTPN1/TCF7/SRC/TCF7L1/WAS	1.24995232342744
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	30/692	333/9376	1.22064260792584	SPP1/COL1A1/HLA-A/COL6A2/TRADD/COL1A2/ATP6V1C1/HDAC2/ATP6V1B2/CREB1/MAP2K2/CREB3/PPP2R1A/GSK3B/TYK2/MAPK3/NFX1/IKBKG/TCIRG1/TCF7/RFNG/HRAS/TCF7L1/TLR3/PRKCZ/TP53/TUBG2/JAK1/CDK4/PRKACA	1.15726817849916
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/692	163/9376	1.32997624029221	MAP2K7/CREB1/TGFB1/MAP2K2/CREB3/TYK2/MAPK3/MAP2K3/IKBKG/IRAK1/SRC/HRAS/TLR3/TP53/JAK1/YWHAB	1.19965043159274
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/692	28/9376	1.93559042113955	HACD3/ACAA2/HACD4/PPT1	1.39953643294232
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/692	28/9376	1.93559042113955	ATP6V1C1/ATP6V1B2/TCIRG1/SLC12A7	1.39953643294232
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/692	71/9376	1.52666286737768	SLC16A3/PDHA1/MAP2K2/MAPK3/PFKL/HRAS/PFKM/TP53	1.25742607780286
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/692	140/9376	1.35491329479769	SPP1/RPS6/MEF2C/SLC9A1/MAP2K2/PRKAG1/MAPK3/MAP1LC3A/HRAS/SPHK2/GNAQ/CALM3/PRKACA/ITPR2	1.19432659109839
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/692	200/9376	1.2871676300578	RPS3/GAPDH/TRADD/ARPC1B/CYTH4/NCL/WIPF1/NCKAP1L/WIPF2/MYO1F/MAPK3/PTPN6/IKBKG/IRAK1/SRC/FCGR2A/MYO1C/PAK2/TUBA1C	1.15878417995352
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/692	19/9376	2.13933678125951	GCSH/PDHA1/DBT	1.4032639934489
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/692	73/9376	1.48483648744952	MAP1S/SUPT4H1/MLLT1/NELFE/CD4/CXCR4/APOBEC3A/FURIN	1.17388078499716
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/692	73/9376	1.48483648744952	HGF/STK4/MAP2K2/MAPK3/HRAS/TP53/CDK4/KIF5B	1.17388078499716
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/692	143/9376	1.32648854036137	C1QA/C1QB/HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DPA1/SNRPB/FCGR2A/HLA-DMB/HLA-DQA1/C2/HLA-DQB1/SNRPD1	1.11056330952722
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/692	30/9376	1.80655105973025	SUCLG1/ACO2/PDHA1/PC	1.24898833768245
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/692	30/9376	1.80655105973025	FOLR2/SLC46A1/ATIC/IKBKG	1.24898833768245
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	19/692	205/9376	1.25577329761737	HLA-A/TRADD/HDAC7/HDAC2/SND1/CREB1/MRPS18B/CREB3/MAPK3/IKBKG/SRC/HRAS/LTBR/TP53/JAK1/SYK/CDK4/PRKACA/YWHAB	1.04520761361281
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/692	52/9376	1.56336149399733	PLTP/APOE/APOC1/SOAT1/NPC2/CYP27A1	1.14991695336662
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/692	75/9376	1.4452408477842	GAPDH/ACO2/ASL/TALDO1/PFKL/PFKM/PC/PRPS1	1.09279723772065
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/692	75/9376	1.4452408477842	CGA/CREB1/CREB3/GPX3/GPX7/GNAQ/PRKACA/ITPR2	1.09279723772065
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/692	170/9376	1.27521251275076	MYL9/MYL6/MAP2K7/ARPC1B/PRKAG1/PPP2R1A/HSPA4/CFTR/SRC/NEDD4L/PRKCZ/CDK4/WAS/VASP/PRKACA/TUBA1C	1.02220012327867
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	16/692	170/9376	1.27521251275076	HGF/GSTP1/SMARCD2/TGFB1/MAP2K2/GSK3B/MAPK3/SMARCC2/TCF7/GAB1/HRAS/TCF7L1/TP53/CDK4/GSTO1/LRP6	1.02220012327867
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/692	122/9376	1.33270160144035	CREB1/EEF2/CREB3/PRKAG1/PPP2R1A/PFKL/CFTR/RAB11B/PFKM/CPT1A/AKT1S1/SCD5	1.04411620721567
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	12/692	122/9376	1.33270160144035	MAP2K7/PTPRC/MAP2K2/PPP2R1A/GSK3B/MAPK3/PTPN6/CD4/IKBKG/HRAS/PAK2/CDK4	1.04411620721567
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/692	122/9376	1.33270160144035	HDAC2/SLC9A1/MAP2K2/GSK3B/MAPK3/PFKL/SRC/HRAS/PFKM/TP53/PRKACA/THRA	1.04411620721567
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/692	122/9376	1.33270160144035	CSH1/CSH2/CREB1/MAP2K2/CREB3/GSK3B/MAPK3/MAP2K3/HRAS/GNAQ/PRKACA/ITPR2	1.04411620721567
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/692	87/9376	1.40163444289416	RALGDS/TGFB1/MAP2K2/GSK3B/MAPK3/TCF7/HRAS/TCF7L1/TP53	1.06239219725212
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/692	31/9376	1.74827521909379	ALDH2/ACOX1/CNDP2/ALDH3B1	1.17796214685206
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/692	232/9376	1.22643013753239	MYL9/ARPC1B/ITGB2/PIP4K2B/CFL1/NCKAP1L/PPP1CC/SLC9A1/MAP2K2/MAPK3/PFN2/PIP5K1C/CXCR4/SRC/HRAS/PPP1R12C/GIT1/ITGAL/PAK2/PFN1/TMSB4X	0.985800177771878
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/692	77/9376	1.40770212446513	HDAC2/TGFB1/MAP2K2/MAPK3/IKBKG/HRAS/TP53/CDK4	1.01402576802563
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/692	32/9376	1.69364161849711	SUCLG1/ACOX1/PCCB/DBT	1.10948770845976
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/692	89/9376	1.37013703968306	MAP2K2/MAPK3/SRC/HRAS/GNAQ/DRD1/PRKACA/TUBA1C/ITPR2	0.990372575573809
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/692	101/9376	1.34149831168088	COL1A1/CYBB/COL1A2/MMP2/TGFB1/MAPK3/HRAS/COL3A1/PRKCZ/CDK4	0.974027159330862
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	16/692	174/9376	1.24589728257259	NSFL1C/MAP2K7/RRBP1/DNAJA2/SEC62/UBE2G2/BAG1/VCP/HSP90AB1/UBXN6/PLAA/LMAN2/MAN1B1/RBX1/PREB/MAN1A2	0.924200112529094
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/692	138/9376	1.27636759654855	FBXW11/PPP1CC/CPEB4/CDC27/PPP2R1A/MAPK3/RBX1/ANAPC13/CALM3/PRKACA/SLK/ITPR2/YWHAB	0.923243936294301
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/692	90/9376	1.35491329479769	CREB1/CREB3/EHMT2/PRKAG1/HRAS/EIF4E2/TP53/AKT1S1/PRKACA	0.955010092265055
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/692	12/9376	2.25818882466281	VKORC1L1/COQ5	1.23107502832141
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/692	44/9376	1.53967419863374	RFC1/PARP2/RFC2/APTX/MBD4	1.01285996798422
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/692	103/9376	1.31544980077445	C1QA/C1QB/CCL3/CCL5/TGFB1/PPP2R1A/MAPK3/IKBKG/IRAK1/GNAQ	0.908693701821445
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/692	23/9376	1.76727821060568	RPA2/RFC1/RFC2	1.03996828217993
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/692	34/9376	1.59401564093846	FBXW11/CREB1/PRKAG1/RBX1	0.979481382510626
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	18/692	203/9376	1.20140095105214	SPP1/HGF/COL1A1/MYL9/COL6A2/COL1A2/PPP1CC/GSK3B/MAPK3/PIP5K1C/SRC/HRAS/RAPGEF1/PPP1R12C/PAK2/TLN1/PARVB/VASP	0.818903292555829
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/692	216/9376	1.19182187968315	CD14/CYBA/CCL3/MAP2K7/CYBB/POU2F2/NCF1/CCL5/GSK3B/MAPK3/MAP2K3/IKBKG/IRAK1/HSPA4/HSP90AB1/SRC/HRAS/TP53/CALM3	0.805111553981278
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/692	69/9376	1.37454971935997	HDAC2/CREB1/PPP1CC/CREB3/DRD1/CALM3/PRKACA	0.881470824787968
Genetic Information Processing	Transcription	hsa03040	Spliceosome	21/692	243/9376	1.17091272389924	SNRPB/CCDC12/XAB2/SNRPB2/LSM4/SART1/TXNL4A/CTNNBL1/PRPF31/CDC5L/PRPF38A/SF3A2/SNRPE/RBM8A/EFTUD2/SNRPF/SF3B4/PRPF6/SNRPA/DHX16/SNRPD1	0.761990543656792
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/692	156/9376	1.21594782866459	TRADD/PIAS1/MAP2K2/PPP2R1A/GSK3B/TYK2/MAPK3/IKBKG/HRAS/TLR3/TP53/JAK1/CDK4/YWHAB	0.76775819063676
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/692	119/9376	1.25244086073736	TNFRSF1B/MAP2K7/TRADD/CREB1/CCL5/RHBDF2/CREB3/MAPK3/MAP2K3/IKBKG/RPS6KA5	0.78230621261431
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/692	83/9376	1.30594052510621	PEX6/CRAT/DHRS4/HMGCL/ACOX1/ACSL3/MPV17/ECH1	0.790272488793367
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/692	71/9376	1.33583000895547	CGA/MAP2K2/GSK3B/MAPK3/GALT/SRC/HRAS	0.801805931509786
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/692	71/9376	1.33583000895547	ATP6V1C1/ATP6V1B2/CCL5/IKBKG/TCIRG1/SRC/GIT1	0.801805931509786
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	17/692	195/9376	1.18120646213132	CYBA/C5AR1/CYBB/HDAC7/ITGB2/HDAC2/NCF1/SLC25A6/MAP2K2/SLC25A5/MAPK3/FPR1/SRC/FCGR2A/ITGAL/ATG7/SYK	0.721813119324849
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/692	108/9376	1.2545493470349	RAE1/PHAX/RBM8A/EEF1A1/AAAS/SUMO3/NUP37/UPF2/KPNA6/SNUPN	0.751051349068595
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/692	60/9376	1.35491329479769	MAP2K2/MAPK3/SRC/HRAS/SPHK2/MAPKAPK3	0.7785059413022
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/692	60/9376	1.35491329479769	MAP2K2/PPP2R1A/MAPK3/HRAS/GNAQ/ITPR2	0.7785059413022
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/692	85/9376	1.27521251275076	CANT1/ENPP1/UCK1/NME3/ADA2/ASMTL/ENTPD6/NME2	0.719490702822116
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/692	37/9376	1.46477112951101	HBB/HBA2/HBA1/GNAQ	0.799592285248478
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/692	61/9376	1.33270160144035	FTL/FTH1/SLC40A1/HMOX2/SLC46A1/MT1X	0.735880266991851
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/692	86/9376	1.26038446027692	MAP2K7/MAP2K2/GSK3B/MAPK3/GAB1/SRC/HRAS/PAK2	0.684754994589142
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/692	15/9376	1.80655105973025	HEXA/ST6GALNAC4	0.882460248343039
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/692	187/9376	1.1592841025007	CYBA/GABARAP/CYBB/CTSB/PKN1/RIPK2/GBP2/CCL5/TYK2/MAPK3/MAP1LC3A/IKBKG/HSP90AB1/BRCC3/JAK1/ITPR2	0.621066191216637
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/692	62/9376	1.31120641432034	HDAC2/PRKAG1/EIF4EBP2/HRAS/AKT1S1/PRKACA	0.693992929310485
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/692	51/9376	1.32834636744871	ATP6V1C1/ATP6V1B2/TCIRG1/CFTR/PRKACA	0.663699761872917
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/692	76/9376	1.24794645573471	PLTP/ACOX1/FABP5/ACSL3/CPT1A/CYP27A1/SCD5	0.612635282157988
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/692	76/9376	1.24794645573471	SLC9A1/CFTR/GNAQ/CALM3/PRKACA/ITPR2/SLC4A2	0.612635282157988
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/692	77/9376	1.23173935890699	RALGDS/TGFB1/MAPK3/IKBKG/TP53/JAK1/CDK4	0.576375906075328
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/692	115/9376	1.17818547373712	MEF2C/PDE4A/CREB1/NACA/CREB3/MAPK3/GNAQ/PRKACA/ITPR2/LRP6	0.542714034047181
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/692	128/9376	1.16437861271676	PDE4A/ATIC/CANT1/NUDT2/ENPP1/NME3/ADA2/ENTPD6/PGM1/PRPS1/NME2	0.528573228810183
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/692	90/9376	1.2043673731535	MAP2K2/MAPK3/PTPN6/MAP2K3/CD4/IKBKG/HRAS/JAK1	0.549917139628557
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/692	154/9376	1.14375797612792	CREM/TPM1/CREB1/PPP1CC/SLC9A1/CREB3/PPP2R1A/MAPK3/TNNT2/RPS6KA5/GNAQ/CALM3/PRKACA	0.507760051689841
NA	NA	hsa04518	Integrin signaling	13/692	154/9376	1.14375797612792	SPP1/HGF/COL1A1/COL6A2/COL1A2/ITGB2/TGFB1/GSK3B/LIMS2/SRC/ITGAL/TLN1/PARVB	0.507760051689841
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/692	103/9376	1.18390482069701	CD14/COL1A1/COL1A2/ITGB2/TGFB1/COL3A1/GNAQ/RAB7A/PRKACA	0.529761476760163
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/692	116/9376	1.1680287024118	CYBA/MYL9/PECAM1/CYBB/ITGB2/MMP2/NCF1/CXCR4/ITGAL/VASP	0.514026788582498
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/692	53/9376	1.27822008943178	AP2S1/GNAQ/AP2A2/PRKACA/CLTC	0.57335995398508
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/692	17/9376	1.59401564093846	DAG1/CD209	0.691968612715
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/692	79/9376	1.20055608399795	ATP6V1C1/ATP6V1B2/TCIRG1/NAPA/AP2S1/AP2A2/CLTC	0.505308669383626
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/692	54/9376	1.2545493470349	RPA2/ERCC1/CENPX/USP1/TELO2	0.529533080314282
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/692	105/9376	1.16135425268373	FCER1G/MAPK3/IKBKG/SRC/HRAS/CD209/SYK/CALM3/ITPR2	0.46934322510323
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/692	93/9376	1.16551681272919	CST3/LYZ/SLC9A1/GNAQ/CALM3/PRKACA/ITPR2/SLC4A2	0.452812275511804
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/692	158/9376	1.1148020779981	HDAC2/TGFB1/FZR1/CDC27/PPP2R1A/GSK3B/CDC25B/RBX1/TP53/ANAPC13/CDK4/YWHAB/TFDP2	0.410807835796461
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/692	158/9376	1.1148020779981	RPS6/ATP6V1C1/ATP6V1B2/MAP2K2/GSK3B/MAPK3/HRAS/EIF4E2/TELO2/AKT1S1/PRR5/MAPKAP1/LRP6	0.410807835796461
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/692	133/9376	1.12060498065974	TYROBP/FCER1G/HLA-A/HCST/ITGB2/MAP2K2/MAPK3/PTPN6/HRAS/ITGAL/SYK	0.395424309905337
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	11/692	133/9376	1.12060498065974	CREB1/PPP1CC/CREB3/PPP2R1A/GSK3B/GNAQ/KIF5B/DRD1/CALM3/PRKACA/ITPR2	0.395424309905337
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/692	56/9376	1.20974401321222	MGAT1/MAN1B1/ALG11/ALG12/MAN1A2	0.444379901992933
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/692	69/9376	1.17818547373712	CTSB/CREB1/GNAQ/CALM3/PRKACA/ITPR2	0.419344317674795
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/692	134/9376	1.11224225692348	MYL9/MYL6/CALD1/PPP1CC/MAP2K2/MAPK3/PPP1R12C/GNAQ/CALM3/PRKACA/ITPR2	0.369406545024441
NA	NA	hsa04981	Folate transport and metabolism	3/692	31/9376	1.31120641432034	FOLR2/SLC46A1/SLCO2B1	0.489912490180935
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/692	109/9376	1.11873574799809	CREB1/PPP1CC/CREB3/PTPRF/PRKAG1/GSK3B/PTPN1/PRKCZ/CPT1A	0.351968614019108
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/692	70/9376	1.16135425268373	TNFRSF1B/TRADD/PRKAG1/IKBKG/ACSL3/CPT1A	0.382495817126254
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/692	83/9376	1.14269795946793	HDAC2/EZH1/RBBP4/MBD6/ASXL2/CBX6/USP16	0.368601941620216
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/692	83/9376	1.14269795946793	CCL4/CCL5/POLR2F/POLR2E/IKBKG/POLR3GL/POLR3K	0.368601941620216
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/692	136/9376	1.09588575314519	RACK1/TRADD/GSK3B/TYK2/EIF3H/IKBKG/IRAK1/CD209/TP53/JAK1/CDK4	0.317955491658221
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/692	150/9376	1.08393063583815	HGF/JUP/TGFB1/MAP2K2/GSK3B/MAPK3/TCF7/GAB1/HRAS/TCF7L1/TP53/LRP6	0.292508301246556
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/692	98/9376	1.1060516692226	PIP4K2B/CDIPT/MTMR6/PIP5K1C/PIP4P1/INPPL1/CALM3/ITPR2	0.297907982496706
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/692	20/9376	1.35491329479769	FDFT1/SOAT1	0.448508767719186
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/692	20/9376	1.35491329479769	CMAS/CYB5R1	0.448508767719186
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/692	33/9376	1.23173935890699	ACO2/PDHA1/DBT	0.37643706159915
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/692	33/9376	1.23173935890699	BET1L/STX4/YKT6	0.37643706159915
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/692	99/9376	1.09487943013955	MMP2/MAP2K2/MAPK3/SRC/HRAS/TP53/CDK4/PRKACA	0.267895034930134
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/692	99/9376	1.09487943013955	RALGDS/MAP2K2/MAPK3/PIP5K1C/HRAS/LYPLA1/SLC44A2/WAS	0.267895034930134
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/692	166/9376	1.06107667664879	MYL9/MEF2C/CREB1/SLC25A6/PPP1CC/MAP2K2/CREB3/SLC25A5/MAPK3/GNAQ/VASP/CALM3/ITPR2	0.22411886004913
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/692	73/9376	1.11362736558714	HGF/MAP2K2/MAPK3/HRAS/TP53/CDK4	0.275113331123784
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/692	300/9376	1.03876685934489	HGF/CD14/CSF1R/MAP2K7/TRADD/MEF2C/STK4/TGFB1/MAP2K2/PPP5C/MAPK3/MAP2K3/IKBKG/IRAK1/HRAS/CDC25B/RPS6KA5/MAPKAPK3/STMN1/PAK2/TP53/PRKACA/ECSIT	0.192642799278846
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/692	193/9376	1.05304142082722	CXCL14/CCL4/CCL3/NCF1/CCL5/GSK3B/MAPK3/IKBKG/CXCR4/SRC/HRAS/PRKCZ/GNAQ/WAS/PRKACA	0.210174628981695
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/692	100/9376	1.08393063583815	CXCL14/CCL4/CSF1R/CCL3/TNFRSF1B/CCL5/CXCR4/LTBR	0.238187475414838
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/692	21/9376	1.29039361409304	ALDH2/ENPP1	0.376056925639499
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/692	155/9376	1.04896513145627	CREB1/MAP2K2/CREB3/GSK3B/MAPK3/AIP/TCF7/TCF7L1/GNAQ/CDK4/PRKACA/ITPR2	0.173517203967819
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/692	75/9376	1.08393063583815	GSTP1/ERCC1/MAPK3/XPA/TP53/GSTO1	0.205998994612737
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/692	35/9376	1.16135425268373	PMM1/PFKL/PFKM	0.269958204151026
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/692	62/9376	1.09267201193362	HDAC2/PSENEN/RFNG/CIR1/APH1A	0.20665936840462
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/692	49/9376	1.1060516692226	CREB1/CREB3/DRD1/PRKACA	0.210098686966363
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/692	76/9376	1.06966839062975	MAP2K2/MAPK3/HRAS/TP53/CDK4/CALM3	0.172139238790404
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/692	63/9376	1.0753280117442	ALDH2/EZH1/EHMT2/SETD1B/SETDB2	0.169340468055579
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/692	63/9376	1.0753280117442	GSK3B/PTCH1/TCF7/TCF7L1/TP53	0.169340468055579
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/692	36/9376	1.12909441233141	ENPP1/PGM1/GYG1	0.219060480104969
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/692	36/9376	1.12909441233141	RPA2/RFC1/RFC2	0.219060480104969
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/692	50/9376	1.08393063583815	AOC1/ALDH2/SMS/CNDP2	0.167971881881096
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/692	23/9376	1.17818547373712	POMGNT1/LARGE1	0.241512450725703
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/692	105/9376	1.03231489127443	CD14/CCL4/TRADD/IKBKG/IRAK1/LTBR/LTB/SYK	0.0939967496197871
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/692	65/9376	1.04224099599822	CREB1/CREB3/GNAQ/PRKACA/ITPR2	0.0964653718830378
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/692	79/9376	1.02904807199824	GSTP1/AKR7A2/GSTO1/ALDH3B1/CYP1B1/ADH5	0.0731877204470264
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/692	38/9376	1.06966839062975	MAPK3/NEDD4L/NR3C2	0.121472905595545
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/692	38/9376	1.06966839062975	PTPRC/CD4/IKBKG	0.121472905595545
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/692	94/9376	1.00897798548764	S100A9/S100A8/TRADD/GSK3B/MAPK3/IKBKG/HSP90AB1	0.0246945332415885
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/692	82/9376	0.991399971803186	GSTP1/CES1/UCK1/NME3/GSTO1/NME2	-0.0220792463580588
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/692	110/9376	0.985391487125591	FZR1/CPEB4/CDC27/MAPK3/HSP90AB1/CDC25B/ANAPC13/PRKACA	-0.0435045800048246
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/692	54/9376	1.00363947762792	ADI1/ENOPH1/DNMT3A/SMS	0.0075711205764026
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/692	26/9376	1.04224099599822	SLC46A1/BTD	0.0608826849078922
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/692	55/9376	0.985391487125591	PSAP/CERK/HEXA/SPHK2	-0.030671490155666
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/692	41/9376	0.991399971803186	RPA2/BABAM1/BRCC3	-0.0155780617287091
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/692	98/9376	0.967795210569777	CREB1/CREB3/PRKD2/GNAQ/CALM3/PRKACA/ITPR2	-0.0904659390674093
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/692	56/9376	0.967795210569777	FBXW11/GSK3B/PTCH1/PRKACA	-0.0682315597548204
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/692	56/9376	0.967795210569777	CD14/ITGB2/VCP/EEF1A1	-0.0682315597548204
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/692	12/9376	1.12909441233141	CD209	0.126312445478614
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/692	99/9376	0.958019501372102	PPP1CC/MAP2K3/SRC/GNAQ/CALM3/PRKACA/ITPR2	-0.118533249301395
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/692	99/9376	0.958019501372102	EMD/TPM1/TGFB1/PRKAG1/TNNT2/DAG1/SNTA1	-0.118533249301395
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/692	184/9376	0.95727569741141	MYL9/CFL1/SEMA6B/GSK3B/MAPK3/PTCH1/CXCR4/SRC/HRAS/RHOD/PRKCZ/PAK2/EPHA3	-0.165218115385921
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/692	42/9376	0.967795210569777	AOC1/ALDH2/CYP1B1	-0.0590459329255323
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/692	86/9376	0.945288345207689	EMD/JUP/TCF7/TCF7L1/DAG1/SNTA1	-0.143879856890955
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/692	115/9376	0.942548378989696	CREB1/CREB3/MAPK3/HRAS/GNAQ/PRKACA/KCNJ12/ITPR2	-0.174985089115918
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/692	103/9376	0.920814860542118	PPP1CC/WDR82/PPP2R1A/RBM8A/PABPC4/SSU72/UPF2	-0.228102973362402
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/692	105/9376	0.903275529865125	EMD/TPM1/TGFB1/TNNT2/DAG1/SNTA1/PRKACA	-0.281349725863656
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/692	362/9376	0.935713601379619	SPP1/HGF/CSH1/CSF1R/COL1A1/RPS6/CSH2/COL6A2/COL1A2/PKN1/CREB1/MAP2K2/CREB3/PPP2R1A/GSK3B/MAPK3/IKBKG/HSP90AB1/HRAS/EIF4E2/TP53/JAK1/SYK/CDK4/YWHAB	-0.352122181137423
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/692	149/9376	0.909337781743415	FCER1G/RALGDS/CYTH4/MAP2K2/MAPK3/PIP5K1C/GAB1/HRAS/SPHK2/SYK	-0.314896615436233
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/692	46/9376	0.88363910530284	FTL/FTH1/HMOX2	-0.223318099834522
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/692	194/9376	0.90793158929742	MYL9/MYL6/TPM1/DCTN4/MYO1F/TNNT2/MYO9B/MYO1C/KIF2A/TUBG2/MYO18A/KIF5B/TUBA1C	-0.365781423030545
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/692	78/9376	0.868534163331851	PIP4K2B/CDIPT/MTMR6/PIP5K1C/INPPL1	-0.329112379218602
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/692	168/9376	0.887145609688962	FTL/FTH1/TRADD/CYBB/CHMP1A/SLC25A6/SLC25A5/TYK2/HSP90AB1/TLR3/JAK1	-0.416647924196912
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/692	226/9376	0.899278735485191	MYL9/PDE4A/CGA/CREB1/PPP1CC/SLC9A1/MAP2K2/CREB3/MAPK3/PTCH1/CFTR/ACOX1/DRD1/CALM3/PRKACA	-0.432656885934292
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/692	16/9376	0.846820809248555	ALDH3B1	-0.173101414130213
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/692	16/9376	0.846820809248555	HEXA	-0.173101414130213
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/692	183/9376	0.888467734293566	REXO1/IMP4/GAR1/MPHOSPH10/WDR43/RPP25/DKC1/UTP14C/XRN2/EIF6/LSG1/TCOF1	-0.430106709612127
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/692	110/9376	0.862217551234892	HDAC2/TGFB1/PPP2R1A/MAPK3/LRRC32/RBX1/EMP3	-0.410320175441189
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/692	17/9376	0.797007820469228	CYP27A1	-0.236465519056013
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/692	17/9376	0.797007820469228	SEPHS2	-0.236465519056013
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/692	201/9376	0.876312081212435	CD14/CSF1R/NUPR1/SPI1/MEF2C/HDAC2/JUP/MLLT1/TFE3/PROM1/TP53/HPGD/KLF3	-0.500381278341327
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/692	97/9376	0.838090697813003	CREB1/MAPK3/RPS6KA5/GNAQ/CALM3/PRKACA	-0.452465904763179
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/692	157/9376	0.863002098597254	FBXW11/ITGB2/PPP1CC/TGFB1/PPP2R1A/GSK3B/TCF7/TCF7L1/PRKCZ/YWHAB	-0.488653047085153
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	15/692	233/9376	0.872261777766752	COL1A1/MYL9/COL6A2/EMD/COL1A2/TPM1/JUP/INF2/FHL3/TNNT2/SDC3/COL3A1/DAG1/TLN1/SNTA1	-0.557356725894509
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/692	18/9376	0.752729608220938	ACSL3	-0.296411894467747
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/692	18/9376	0.752729608220938	HEXA	-0.296411894467747
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/692	52/9376	0.781680746998666	CGA/PRKACA/CYP1B1	-0.445626854067097
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/692	68/9376	0.797007820469228	DHRS4L2/DHRS4/DGAT1/ADH5	-0.474224900087427
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/692	36/9376	0.752729608220938	C1GALT1/ST6GALNAC4	-0.419593456917477
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/692	19/9376	0.713112260419836	HEXA	-0.353345245880459
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/692	37/9376	0.732385564755507	ALDH3B1/ADH5	-0.460403893993494
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/692	148/9376	0.823933760349945	MAP2K2/GSK3B/MAPK3/TCF7/HRAS/TCF7L1/TP53/CDK4/LRP6	-0.609441370092076
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/692	133/9376	0.814985440479812	GABARAP/STK4/TGFB1/MAP2K2/PRKAG1/MAPK3/PRMT1/HRAS	-0.606602265681808
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/692	38/9376	0.713112260419836	SIRT2/ENPP1	-0.500213755356326
NA	NA	hsa04517	IgSF CAM signaling	19/692	299/9376	0.860981692346357	MYL9/MYL6/ARPC1B/LMO7/ITGB2/CD84/MAP2K2/MBP/PTPRF/GSK3B/MAPK3/PTPN6/SRC/GIT1/ITGAL/PAK2/CD209/PPFIA1/TUBA1C	-0.689628501072709
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/692	39/9376	0.694827330665481	GCSH/ATIC	-0.53907977522172
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/692	89/9376	0.761187244268364	SPP1/COL1A1/COL6A2/COL1A2/DAG1	-0.638989289416546
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/692	73/9376	0.74241824372476	GSTP1/GSTO1/ALDH3B1/ADH5	-0.623654122749594
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/692	21/9376	0.645196807046518	B3GAT3	-0.459466708198402
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/692	41/9376	0.660933314535457	GCSH/GRHPR	-0.614184237008937
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/692	217/9376	0.811699208864974	PAQR7/CREB1/MAP2K2/CREB3/MAPK3/HSP90AB1/AIP/SRC/HRAS/KPNA6/GSTO1/PRKACA/CYP1B1	-0.792203506066962
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/692	23/9376	0.58909273686856	ASL	-0.556943380728525
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/692	23/9376	0.58909273686856	ICMT	-0.556943380728525
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/692	23/9376	0.58909273686856	ATP6AP2	-0.556943380728525
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/692	78/9376	0.694827330665481	ARPC1B/GAB1/SRC/CLTC	-0.763971126055356
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/692	24/9376	0.564547206165703	B3GAT3	-0.602938798418159
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/692	44/9376	0.615869679453494	TAF11/TAF3	-0.720935381301328
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/692	45/9376	0.60218368657675	CFTR/ABCA2	-0.755098362850632
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/692	178/9376	0.761187244268364	FBXW11/FRZB/GSK3B/TCF7/CHD8/TCF7L1/RBX1/TP53/PRKACA/LRP6	-0.908028744354805
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/692	26/9376	0.521120497999111	ACOX1	-0.690217385745262
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/692	47/9376	0.57655884885008	MAPK3/PRKCZ	-0.821491779897796
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/692	27/9376	0.501819738813958	HMGCL	-0.731753142577284
NA	NA	hsa03272	Virion - Hepatitis viruses	2/692	48/9376	0.564547206165703	CD63/CHMP1A	-0.853780456445011
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/692	102/9376	0.664173183724357	SLC9A1/CFTR/GNAQ/ITPR2/SLC4A2	-0.962632877548456
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/692	28/9376	0.483897605284889	MOCS2	-0.772030247651325
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/692	103/9376	0.657724900387227	COL1A1/COL14A1/COL6A2/COL1A2/COL3A1	-0.985967423484966
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/692	49/9376	0.553025834611301	C1GALT1/RFNG	-0.885499360306508
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/692	86/9376	0.630192230138459	CREB1/CREB3/GNAQ/PRKACA	-0.972514708371053
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/692	104/9376	0.651400622498888	CDIPT/LPCAT1/PLD3/LYPLA1/LYPLA2	-1.00910264252625
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/692	29/9376	0.46721148096472	RASSF4	-0.811141297957602
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/692	29/9376	0.46721148096472	CALM3	-0.811141297957602
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/692	70/9376	0.580677126341866	GSTP1/GSTO1/CYP1B1	-0.99401932413875
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/692	51/9376	0.531338546979485	LPCAT1/PLD3	-0.947324306297725
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/692	30/9376	0.451637764932563	PIGX	-0.84916885070336
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/692	89/9376	0.608949795414691	GABARAP/SRC/TRAK2/PRKACA	-1.04632975566413
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/692	191/9376	0.709378688375753	HDAC7/HDAC2/CREB1/PPP1CC/CREB3/MAPK3/HRAS/DRD1/CALM3/PRKACA	-1.1454689987334
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/692	90/9376	0.60218368657675	SLC9A1/CFTR/PRKACA/SLC4A2	-1.07045467091744
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/692	31/9376	0.437068804773448	ALDH2	-0.88618682316132
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/692	298/9376	0.727470225394732	CSH1/CXCL14/CCL4/CSF1R/CCL3/CSH2/TNFRSF1B/CCL5/TGFB1/IL1RN/CD4/CNTFR/CXCR4/LTBR/LTB/TNFRSF21	-1.34960220117596
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/692	115/9376	0.58909273686856	MAPK3/HRAS/GNAQ/PRKACA/ITPR2	-1.25153377386057
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/692	168/9376	0.645196807046518	CSH1/CSH2/PIAS1/TYK2/PTPN6/CNTFR/HRAS/JAK1	-1.30990042509712
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/692	59/9376	0.459292642304301	CGA/PRKACA	-1.1760587444503
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/692	37/9376	0.366192782377753	ASL	-1.09040198361448
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/692	238/9376	0.683149560402196	HGF/CSF1R/RALGDS/STK4/MAP2K2/MAPK3/IKBKG/GAB1/HRAS/PAK2/CALM3/PRKACA	-1.3976421632263
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/692	154/9376	0.615869679453494	ALDH2/PMM1/MOCS2/VKORC1L1/COQ5/NME3/NME2	-1.3567666759775
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/692	63/9376	0.430131204697679	PTGDS/HPGD	-1.28108848610621
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/692	65/9376	0.416896398399289	ALDH2/DGAT1	-1.33162830197279
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/692	144/9376	0.564547206165703	MAP2K2/GSK3B/MAPK3/TCF7/HRAS/JAK1	-1.48645993311201
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/692	43/9376	0.31509611506923	DGAT1	-1.27066773546881
NA	NA	hsa04382	Cornified envelope formation	10/692	217/9376	0.624384006819211	S100A9/S100A8/S100A11/KRT7/S100A4/JUP/PPP2R1A/S100A1/FURIN/BLMH	-1.58026052327772
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/692	91/9376	0.446674712570666	PDE4A/DRD1/PRKACA	-1.49723178566912
NA	NA	hsa04519	Cadherin signaling	21/692	404/9376	0.704286613632461	ARPC1B/KRT7/JUP/PSENEN/NCKAP1L/PPP1CC/MAP2K2/GSK3B/MYO1F/MAPK3/MAP2K3/IKBKG/TCF7/PCDH12/HRAS/TCF7L1/MYO1C/APH1A/VASP/LRP6/YWHAB	-1.71512513991736
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/692	93/9376	0.437068804773448	IKBKG/TP53/CDK4	-1.54003784427728
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/692	72/9376	0.376364804110469	TRADD/IKBKG	-1.49948039774677
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/692	116/9376	0.46721148096472	MAPK3/GNAQ/PRKACA/ITPR2	-1.62988565347689
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/692	75/9376	0.36131021194605	TP53/CDK4	-1.56759749160308
NA	NA	hsa04081	Hormone signaling	9/692	219/9376	0.55681368279357	CSH1/CSH2/SLC40A1/CGA/SRC/GNAQ/DRD1/PRKACA/THRA	-1.87331397083079
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/692	254/9376	0.533430431022712	HGF/SLC25A6/SLC25A5/CXCR4/SPHK2/GNAQ/DRD1/CALM3/PRKACA/ITPR2	-2.12797740278185
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/692	66/9376	0.205289893151165	CYP1B1	-1.82887760357042
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/692	86/9376	0.157548057534615	PRKACA	-2.2154669855912
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/692	323/9376	0.461425580271658	TPM1/HDAC2/MAP2K2/MAPK3/HRAS/DNMT3A/CDC25B/RPS6KA5/STMN1/TP53/CYP1B1	-2.78054226730961
NA	NA	hsa04082	Neuroactive ligand signaling	3/692	199/9376	0.204258285647893	GNAQ/DRD1/PRKACA	-3.20277976226156
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/692	370/9376	0.366192782377753	CSH1/C5AR1/CSH2/SPX/CGA/S1PR2/FPR1/DRD1/THRA/KISS1	-3.51132355003064
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/692	449/9376	0.0603524852916565	CALM3/PRKACA	-5.75988948340785