category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	60/960	233/9376	2.51502145922747	COL1A1/COL6A2/FN1/COL3A1/DCN/FBLN1/VIM/COL6A1/TPM1/VCAN/COL4A2/MYL9/COL1A2/COL4A1/FMNL1/TLN1/SYNE2/SPTBN1/MYH9/ITGA6/FBN1/ZYX/DSC2/NID1/COL5A1/LBR/MYH10/ITGA4/TPM2/FHL1/LAMA2/ATP1A1/PLEC/DSP/BGN/VCL/TNNT3/LMOD1/TTN/THBS1/DIAPH1/PDLIM5/DES/ITGAV/SYNE1/COL5A2/COL6A3/FBN2/HSPG2/SPTAN1/FBLN2/PDLIM7/CSRP2/PDLIM1/TNNT2/ELN/ITGA1/EMD/NEBL/MYL5	7.90898544502101
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	59/960	238/9376	2.42114845938375	RPL13A/RPS11/RPL7/RPS20/RPS8/RPS14/RPS26/RPL23/IL6ST/RPLP2/RPS16/RPL31/C7/RPL27A/NRP1/RPL18A/RPL4/RPL10/RPS5/RPSA/RPL18/JAK1/RPS9/JUN/RPS2/RPL5/RPL10A/RPLP0/PIK3R1/RPL13/RPL3/RPL8/RPS15/MAVS/UBA52/RPL29/RPS12/RPS3/RPS4X/RPS3A/RPS28/PRKCB/IL6R/HBEGF/TNF/IRF3/RPL21/IKBKB/EGFR/RPL28/RPL15/RPS6/C5AR1/C1R/RPS27A/RPLP1/PIK3R3/MAPK14/C1S	7.50016368432728
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	53/960	203/9376	2.54991789819376	COL1A1/COL6A2/HGF/FN1/COL6A1/FLNA/ROCK1/COL4A2/MYL9/COL1A2/PPP1R12A/COL4A1/JUN/TLN1/PIK3R1/CCND2/TNXB/ROCK2/LAMC1/ITGA6/ZYX/ACTN4/SPP1/PRKCB/FLT1/ITGA4/LAMB1/PDGFRA/EGFR/LAMA2/VCL/LAMA4/IGF1R/THBS1/MYLK/DIAPH1/BIRC3/ARHGAP35/ITGAV/RAC2/FYN/LAMB2/COL6A3/GSK3B/SOS1/VTN/RAF1/ACTN1/LAMC3/ITGA1/PIK3R3/PPP1R12B/MYL5	7.53996633796157
NA	NA	hsa04518	Integrin signaling	42/960	154/9376	2.66363636363636	COL1A1/COL6A2/HGF/FN1/COL6A1/FLNA/COL4A2/COL1A2/COL4A1/TLN1/PIK3R1/CCND2/TNXB/LAMC1/ITGA6/FBN1/ITGAX/ACTN4/SPP1/FLT1/ITGA4/LAMB1/PDGFRA/ARHGEF6/EGFR/LAMA2/ITGAL/VCL/LAMA4/IGF1R/THBS1/ITGAV/RAC2/LAMB2/COL6A3/GSK3B/VTN/ACTN1/LAMC3/ITGA1/ICAM3/PIK3R3	7.0303119716883
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	49/960	205/9376	2.33447154471545	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/CD36/MT-ND4L/COL1A1/MT-ATP8/COL3A1/MT-ND6/COX4I1/SLC25A6/ATP5F1D/COL1A2/PIK3R1/MMP2/NDUFS7/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/UQCRC1/NDUFS6/PRKCB/NCF1/ATP5MC1/PLCB2/NDUFV1/NDUFS1/RAC2/COX4I2/SMAD2/SLC2A1/PDHB/GSK3B/PDK2/NDUFA4L2/SLC25A4/PPIF/PIK3R3/MAPK14/CAMK2G/INSR	6.5244858376761
Genetic Information Processing	Translation	hsa03010	Ribosome	48/960	222/9376	2.11171171171171	RPL13A/RPS11/RPL7/RPS20/RPS8/RPS14/RPS26/RPL23/RPLP2/RPS16/RPL31/RPL27A/RPL18A/RPL4/RPL10/RPS5/RPSA/RPL18/RPS9/RPS2/RPL5/RPL10A/RPLP0/RPL13/RPL3/RPL8/RPS15/UBA52/RPL29/RPS12/RPS3/RPS4X/RPS3A/MRPS21/RPS28/RACK1/MRPS34/RPL21/RPL28/RPL15/RPS6/MRPS5/RPS27A/RPLP1/MRPS25/MRPL12/MRPL28/MRPS26	5.66150122219254
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	25/960	89/9376	2.7434456928839	CD36/COL1A1/COL6A2/FN1/COL6A1/COL4A2/COL1A2/COL4A1/TNXB/LAMC1/ITGA6/CD44/SPP1/ITGA4/LAMB1/LAMA2/LAMA4/THBS1/ITGAV/LAMB2/COL6A3/HSPG2/VTN/LAMC3/ITGA1	5.58128366516212
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/960	138/9376	2.33550724637681	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/COX4I1/ATP6V0D1/ATP5F1D/ATP6V0B/ATP6V0A1/NDUFS7/NDUFB7/NDUFS8/NDUFB10/ATP5ME/ATP5F1A/UQCRC1/NDUFS6/ATP5MC1/NDUFV1/NDUFS1/COX4I2/TCIRG1/PPA1/NDUFA4L2	5.337835729747
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	65/960	362/9376	1.7536832412523	COL1A1/CSH1/COL6A2/HGF/FN1/COL6A1/FOXO3/COL4A2/PRLR/COL1A2/COL4A1/JAK1/PIK3R1/CSH2/CSF3R/FGFR1/CCND2/TNXB/MCL1/ATF4/CREB3L2/LAMC1/NR4A1/IL2RA/ITGA6/CDK6/GNG2/SPP1/JAK2/FLT1/IL6R/ITGA4/LAMB1/PDGFRA/IKBKB/EGFR/LAMA2/CREB1/RPS6/LAMA4/CREB3L1/IGF1R/AREG/THBS1/CDKN1A/ITGAV/RXRA/IL2RG/FGF7/LAMB2/COL6A3/PPP2R2A/TSC2/ATF6B/GSK3B/SOS1/IL4R/VTN/RAF1/LAMC3/ITGA1/PIK3R3/MAGI1/RPS6KB2/INSR	4.93915616973684
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	61/960	333/9376	1.78908908908909	COL1A1/COL6A2/FN1/COL6A1/RBPJ/ATM/ATP6V0D1/COL4A2/COL1A2/ATP6V0B/COL4A1/ATP6V0A1/CHD4/JAK1/PKM/PIK3R1/APC/CCND2/UBE3A/EP300/TNXB/CREB3L2/LAMC1/ITGA6/CDK6/BCAP31/SPP1/NFX1/TNF/ITGA4/LAMB1/WNT2/IRF3/IKBKB/EGFR/LAMA2/MAML2/CREB1/LAMA4/CREB3L1/NOTCH2/THBS1/CDKN1A/ITGAV/DLG1/LAMB2/COL6A3/PPP2R2A/UBR4/TSC2/TCIRG1/TCF7L2/GSK3B/SOS1/VTN/RAF1/LAMC3/ITGA1/PIK3R3/MAGI1/RPS6KB2	4.95176790924229
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/960	227/9376	1.9791483113069	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/MT-ATP8/HGF/MT-ND6/COX4I1/SLC25A6/FOXO3/ATP5F1D/JUN/PIK3R1/NDUFS7/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/UQCRC1/EPHX1/NDUFS6/SLC26A2/NCF1/ATP5MC1/IKBKB/EGFR/NDUFV1/NDUFS1/MAP2K7/COX4I2/NDUFA4L2/SOS1/SLC25A4/RAF1/MAP3K14/PPIF/PIK3R3/ABL2/MAPK14	5.04362728328994
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	47/960	235/9376	1.95333333333333	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/COX4I1/ARID1A/ATP5F1D/ARID1B/FGFR1/NDUFS7/CREB3L2/NDUFB7/NDUFS8/NDUFB10/ATP5ME/ATP5F1A/UQCRC1/SMARCA4/NDUFS6/ATP5MC1/NDUFV1/CREB1/RPS6/CREB3L1/SMARCC1/SMARCC2/NDUFS1/PRKAG2/COX4I2/TSC2/COA1/NDUFA4L2/SOS1/PNPLA2/NDUFAF8/MAPK14/RPS6KB2/PRKG1	4.99862142576274
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	42/960	204/9376	2.01078431372549	COL1A1/HGF/FN1/DCN/FLNA/ITPR2/ROCK1/LUM/COL1A2/PPP1R12A/TIMP3/GPC3/PIK3R1/MMP2/FGFR1/EZR/ROCK2/PTPN6/CD44/CBL/PRKCB/HBEGF/TNF/WNT2/EGFR/TIAM1/RPS6/IGF1R/THBS1/CDKN1A/ITGAV/SMAD2/HSPG2/SOS1/VTN/ARHGEF1/RAF1/PIK3R3/MAPK14/CAMK2G/RPS6KB2/PPP1R12B	4.9295803012251
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	51/960	275/9376	1.81127272727273	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/COX4I1/C7/ITPR2/SLC25A6/ATP5F1D/PIK3R1/CCL5/PSMD7/NDUFS7/ATF4/CREB3L2/LAMC1/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/UQCRC1/NDUFS6/TNF/NCF1/ATP5MC1/NDUFV1/CREB1/CREB3L1/RYR1/NDUFS1/PSMD13/RAC2/FYN/COX4I2/ATF6B/GSK3B/NDUFA4L2/SLC25A4/PPIF/TUBB4B/PIK3R3/MAPK14	4.6116576273811
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	43/960	232/9376	1.81020114942529	FN1/C7/ROCK1/WASF2/MYL9/IQGAP2/PPP1R12A/PIK3R1/APC/FGFR1/EZR/ROCK2/MYH9/ITGA6/ITGAX/ACTN4/MYH10/ITGA4/PDGFRA/ARHGEF6/EGFR/ITGAL/TIAM1/VCL/MYLK/DIAPH1/ARHGAP35/ITGAV/PIKFYVE/ABI2/RAC2/FGF7/RGCC/SOS1/ENAH/ARHGEF1/RAF1/ACTN1/SPATA13/ITGA1/PIK3R3/PPP1R12B/MYL5	4.22023981121756
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/960	93/9376	2.31039426523297	ROCK1/WASF2/MYL9/FGFR1/EP300/ROCK2/PTPN6/ACTN4/EGFR/FER/VCL/IGF1R/KRIT1/RAC2/FYN/PTPRM/TCF7L2/ACTN1/LMO7/TJP1/INSR/MYL5	4.28911483634725
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	17/960	63/9376	2.63544973544974	KMT2C/ASH1L/KMT2A/HADHA/KMT2E/SETD2/NSD3/NSD1/PRDM2/DHTKD1/KMT5B/KMT2B/PHYKPL/SETDB2/EHMT1/ALDH2/EZH1	4.3987680855911
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	24/960	110/9376	2.13090909090909	MKNK1/LDHB/TFRC/TIMP1/PIK3R1/ELOB/EP300/EPAS1/PRKCB/FLT1/IL6R/EGFR/RPS6/IGF1R/CDKN1A/LTBR/SLC2A1/PDHB/PDK1/PIK3R3/CAMK2G/HK1/RPS6KB2/INSR	4.02945473204395
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/960	93/9376	2.20537634408602	FN1/COL4A2/COL4A1/PIK3R1/LAMC1/ITGA6/CDK6/LAMB1/IKBKB/LAMA2/LAMA4/SKP2/BIRC3/CDKN1A/ITGAV/RXRA/LAMB2/POLK/LAMC3/TRAF5/PIK3R3	3.94537560028331
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	22/960	100/9376	2.14866666666667	CD36/HLA-DRB5/CD37/TFRC/HLA-DMB/CSF3R/CR1/CD55/CD9/IL2RA/ITGA6/CD44/IL6R/CSF2RA/TNF/ITGA4/ANPEP/CD7/CD24/IL4R/ITGA1/IL1R1	3.90015655019443
NA	NA	hsa04517	IgSF CAM signaling	49/960	299/9376	1.60055741360089	CD84/NRP1/MYL9/CD209/PIK3R1/SRGAP3/FGFR1/EZR/NRP2/SPTBN1/PTPN6/MYH9/JAML/CADM3/ITGAX/RASA1/ACTN4/MYH10/PRKCB/ITGA4/SRGAP1/ITGAL/CSK/VCL/MYLK/EPB41L1/CD48/CASK/ERC1/FYN/SLITRK4/SPTAN1/GSK3B/SLIT2/CLMP/ACTN1/CADM1/LMO7/TUBB4B/RAPGEF6/PTPRD/ICAM3/PIK3R3/APP/MAGI1/MAPK14/NFASC/TJP1/TRIO	3.56440751185543
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/960	103/9376	2.08608414239482	COL1A1/FN1/COL3A1/COL4A2/COL1A2/COL4A1/HSPB1/PIK3R1/LAMC1/ACTN4/PRKCB/TNF/LAMB1/PLCB2/LAMA2/VCL/LAMA4/LAMB2/ACTN1/LAMC3/PIK3R3/IL1R1	3.74317685212892
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/960	227/9376	1.67797356828194	ITPR2/ROCK1/AKAP13/TAPBP/JAK1/PIK3R1/CCL5/IL10RA/ROCK2/ATF4/CREB3L2/CDK6/GNG2/PRKCB/IL6R/TNF/PDGFRA/IRF3/PLCB2/IKBKB/EGFR/CREB1/CREB3L1/CDKN1A/ITGAV/RAC2/NFATC3/TSC2/ATF6B/GSK3B/SOS1/ARHGEF1/RAF1/TRAF5/PIK3R3/MAPK14/PTK2B/RPS6KB2/IL1R1	3.49226562191806
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/960	308/9376	1.55378787878788	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/COX4I1/GPX3/SLC25A6/ATP5F1D/AP2S1/RB1CC1/EP300/PSMD7/NDUFS7/CREB3L2/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/REST/UQCRC1/NDUFS6/ATP5MC1/PLCB2/NDUFV1/CREB1/CREB3L1/NDUFS1/MAP2K7/PSMD13/PIK3C3/COX4I2/POLR2I/AP2A1/TGM2/NDUFA4L2/SLC25A4/PPIF/TUBB4B/HIP1/DCTN5	3.33757811936564
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	29/960	157/9376	1.80403397027601	MT-CYB/MT-CO3/MT-CO2/MT-CO1/COX4I1/JUN/PIK3R1/MLXIP/NDUFS7/ATF4/NDUFB7/NDUFS8/NDUFB10/UQCRC1/NDUFS6/IL6R/TNF/IKBKB/NDUFV1/MAP3K11/NDUFS1/PRKAG2/RXRA/COX4I2/GSK3B/NDUFA4L2/PIK3R3/MAPK14/INSR	3.43123693400325
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	38/960	224/9376	1.65684523809524	HLA-DRB5/ATM/NRP1/SLC25A6/JAK1/JUN/TLN1/HLA-DMB/PIK3R1/TSPO/CCND2/EP300/ATF4/CREB3L2/IL2RA/ANAPC5/TNF/ETS1/IKBKB/ITGAL/CREB1/CREB3L1/MAP3K3/CDKN1A/LTBR/NFATC3/IL2RG/TRRAP/SMAD2/DLG1/SLC2A1/ATF6B/SLC25A4/MAP3K14/PIK3R3/ANAPC7/EGR2/IL1R1	3.3604500974524
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/960	106/9376	1.93490566037736	GSTP1/PIK3R1/FGFR1/EP300/ATF4/CREB3L2/PDGFRA/IKBKB/FOLR3/EGFR/CREB1/CREB3L1/IGF1R/CDKN1A/SPINT1/TCF7L2/GSK3B/SOS1/RAF1/SLC46A1/PIK3R3	3.26925838353482
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	17/960	80/9376	2.07541666666667	HGF/FOXO3/JAK1/PIK3R1/JAK2/PRKCB/IL6R/PDGFRA/EGFR/RPS6/IGF1R/GSK3B/SOS1/RAF1/NF1/PIK3R3/RPS6KB2	3.2624366712039
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	23/960	122/9376	1.84125683060109	NCOR1/PIK3R1/EP300/PRKCB/MED13L/NCOA1/PLCB2/ATP1A1/NOTCH2/MED13/ITGAV/RXRA/NCOA3/BMP4/SLC2A1/TSC2/GSK3B/THRA/RAF1/PFKFB2/PIK3R3/MED1/MED16	3.15872750852756
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	34/960	205/9376	1.61983739837398	DDX3X/REL/IL6ST/RBPJ/ATP6V0D1/CHD4/JAK1/JUN/PKM/PIK3R1/CCND2/UBE3A/EP300/ATF4/CREB3L2/CDK6/ACTN4/IRF3/CREB1/CREB3L1/SKP2/CDKN1A/LTBR/DDB1/HDAC7/DLG1/USP7/UBR4/ATF6B/SND1/ACTN1/TRAF5/PIK3R3/EGR2	3.03050323056187
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	42/960	268/9376	1.53059701492537	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/MT-ATP8/MT-ND6/COX4I1/ITPR2/SLC25A6/ATP5F1D/UBE2G2/PSMD7/NDUFS7/UBA52/ATF4/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/UQCRC1/NDUFS6/SLC11A2/ATP5MC1/NDUFV1/LRRK2/NDUFS1/PSMD13/COX4I2/RPS27A/SLC39A4/NDUFA4L2/SLC25A4/PPIF/TUBB4B/CAMK2G	2.97638481189348
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/960	163/9376	1.67770961145194	DDX3X/JAK1/JUN/PIK3R1/EP300/MAVS/ATF4/CREB3L2/JAK2/PRKCB/TNF/IRF3/IKBKB/CREB1/CREB3L1/CDKN1A/STAT6/MAP2K7/DDB1/NFATC3/ATF6B/HSPG2/SOS1/RAF1/PIK3R3/MAPK14/PTK2B/EGR2	2.94784947071156
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	18/960	93/9376	1.89032258064516	HLA-DRB5/RBPJ/JAK1/JUN/HLA-DMB/IL2RA/JAK2/IKBKB/MAML2/NOTCH2/STAT6/NFATC3/IL2RG/CD247/RUNX3/IL4R/GATA3/MAPK14	2.91415789209151
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/960	93/9376	1.89032258064516	ITPR2/JUN/MAP3K2/MMP2/CGA/ATF4/PRKCB/HBEGF/PLCB2/EGFR/MAP3K3/MAP2K7/SOS1/RAF1/MAP3K4/MAPK14/CAMK2G/PTK2B	2.91415789209151
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/960	130/9376	1.72794871794872	COL1A1/COL3A1/COL4A2/COL1A2/COL4A1/JUN/PIK3R1/MMP2/ATF4/CREB3L2/GNG2/PLCB2/EGFR/CREB1/CREB3L1/MAP2K7/SMAD2/ATF6B/ACTA2/SOS1/RAF1/PIK3R3/MAPK14	2.82269470397548
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	20/960	109/9376	1.79204892966361	HLA-DRB5/IL6ST/JAK1/JUN/HLA-DMB/IL2RA/JAK2/IL6R/IKBKB/STAT6/RXRA/NFATC3/IL2RG/SMAD2/CD247/RORA/IL4R/GATA3/MAPK14/IL1R1	2.80907975752688
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	21/960	117/9376	1.75299145299145	BPTF/BAZ2B/ARID1A/RSF1/ARID1B/CHD4/PBRM1/BAZ1B/EPC1/BAZ2A/SMARCA4/BRD9/SMARCC1/INO80D/SMARCC2/CHD3/TRRAP/BRD8/MBD3/EP400/INO80	2.76802065690074
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/960	142/9376	1.65070422535211	ELOB/BIRC6/UBE2G2/UBE3A/UBA52/WWP1/ANAPC5/CBL/PIAS2/MGRN1/HERC1/STUB1/HUWE1/SKP2/HERC2/BIRC3/FBXW7/DDB1/UBE4A/UBR5/RPS27A/RHOBTB1/UBA6/ANAPC7	2.63876828210084
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	27/960	168/9376	1.56964285714286	CSH1/IL6ST/PRLR/JAK1/PIK3R1/CSH2/CSF3R/IL10RA/CCND2/EP300/MCL1/PTPN6/IL2RA/PIAS2/JAK2/IL6R/CSF2RA/PDGFRA/FHL1/EGFR/CDKN1A/STAT6/IL2RG/SOS1/IL4R/RAF1/PIK3R3	2.51618768771758
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/960	86/9376	1.81705426356589	JUN/PIK3R1/CBL/PRKCB/HBEGF/EGFR/AREG/CDKN1A/MAP2K7/GSK3B/SOS1/RAF1/PIK3R3/ABL2/CAMK2G/RPS6KB2	2.57075483045083
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/960	101/9376	1.74059405940594	COL1A1/FN1/COL3A1/COL4A2/COL1A2/COL4A1/JUN/PIK3R1/MMP2/JAK2/PRKCB/TNF/PLCB2/DIAPH1/SMAD2/F3/PIK3R3/MAPK14	2.52727407957948
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/960	116/9376	1.68390804597701	ROCK1/MYL9/PIK3R1/MMP2/EZR/ROCK2/ACTN4/PRKCB/ITGA4/NCF1/ITGAL/VCL/ARHGAP35/RAC2/ACTN1/PIK3R3/MAPK14/PTK2B/THY1/MYL5	2.50316573748182
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/960	109/9376	1.70244648318043	CD36/OGA/PIK3R1/MLXIP/CREB3L2/PRKCB/TNF/IKBKB/CREB1/CREB3L1/OGT/PRKAG2/SLC2A1/GSK3B/PPARGC1B/SLC27A1/PIK3R3/RPS6KB2/INSR	2.49129583128928
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/960	88/9376	1.77575757575758	SERPINE2/C7/CR1/CD55/ITGAX/SERPINA1/CD46/C4BPB/C5AR1/PROS1/C1R/F3/VTN/CLU/TFPI/C1S	2.4693045091094
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	53/960	388/9376	1.33410652920962	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/APOE/MT-ATP8/MT-ND6/COX4I1/ITPR2/SLC25A6/ATP5F1D/LRP1/PIK3R1/APC/RB1CC1/PSMD7/NDUFS7/ATF4/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/UQCRC1/NDUFS6/SLC11A2/TNF/WNT2/ATP5MC1/PLCB2/IKBKB/NDUFV1/NDUFS1/MAP2K7/PSMD13/PIK3C3/COX4I2/SLC39A4/GSK3B/NDUFA4L2/SLC25A4/RAF1/PPIF/TUBB4B/PIK3R3/APP/INSR	2.27006182360527
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/960	142/9376	1.58192488262911	ITPR2/FOSB/JAK1/JUN/PIK3R1/LILRB5/LILRB3/TNFRSF11A/ACP5/TNF/NCF1/LILRB2/IKBKB/CREB1/CYLD/MAP2K7/TREM2/FYN/MAP3K14/PIK3R3/TEC1/MAPK14/IL1R1	2.35985085545742
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/960	119/9376	1.64145658263305	CFLAR/JUN/PIK3R1/TNFRSF1B/CCL5/ATF4/CREB3L2/TNF/IKBKB/CREB1/CREB3L1/CYLD/BIRC3/MAP2K7/DNM1L/ATF6B/MAP3K14/TRAF5/PIK3R3/MAPK14	2.37834036297778
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	16/960	90/9376	1.7362962962963	FOXO3/PIK3R1/RB1CC1/ATF4/CREB3L2/CREB1/CREB3L1/IGF1R/PRKAG2/EHMT1/TSC2/ATF6B/CAMKK2/PIK3R3/RPS6KB2/INSR	2.3704342975268
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/960	99/9376	1.67710437710438	WASF2/JUN/PIK3R1/DGKZ/GPCPD1/PRKCB/DGKH/PDGFRA/EGFR/PCYT1A/RAC2/PLPP3/TSC2/SOS1/RAF1/PIK3R3/RPS6KB2	2.28737743036548
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/960	17/9376	2.87254901960784	CD209/TFRC/NRP2/MYH9/MYH10	2.6098246205187
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	36/960	253/9376	1.3897233201581	ATM/CYTH4/ITPR2/FOXO3/ROCK1/WASF2/MYL9/JUN/TLN1/PIK3R1/CCL5/ROCK2/UBA52/CAPNS1/CD44/ACTN4/TNF/IRF3/PLCB2/IKBKB/EGFR/VCL/DIAPH1/PIK3C3/RPS27A/ARHGEF2/GSK3B/ACTN1/TRAF5/PIK3R3/MAPK14/HK1/RPS6KB2/RRAGB/IL1R1/MYL5	2.12234610316875
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/960	71/9376	1.78826291079812	ATP6V0D1/ATP6V0B/ATP6V0A1/JUN/CCL5/HBEGF/IKBKB/EGFR/CSK/TCIRG1/MAP3K14/MAPK14/TJP1	2.25169969835007
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/960	71/9376	1.78826291079812	LDHB/PKM/PIK3R1/FGFR1/PDGFRA/EGFR/SLC2A1/PDHB/RAF1/PDK1/SLC16A3/PIK3R3/HK1	2.25169969835007
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/960	30/9376	2.27888888888889	MTHFR/TNF/IKBKB/FOLR3/MTR/ABCC5/SLC46A1	2.36945761555558
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	21/960	133/9376	1.54210526315789	ATM/FOXO3/PIK3R1/CCND2/EP300/DEPP1/GABARAPL1/IKBKB/EGFR/IGF1R/SKP2/CDKN1A/PRKAG2/USP7/SOS1/RAF1/PLK3/PIK3R3/MAPK14/HOMER1/INSR	2.12652924169742
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	15/960	87/9376	1.68390804597701	JUN/PIK3R1/APC/EGFR/AREG/CDKN1A/RAC2/SMAD2/TCF7L2/GSK3B/SOS1/RAF1/POLK/PIK3R3/RPS6KB2	2.16441855960523
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	62/960	480/9376	1.26152777777778	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/FUS/MT-ATP8/MT-ND6/COX4I1/GPX3/ITPR2/SLC25A6/ATP5F1D/ATXN2/TNFRSF1B/APC/RB1CC1/UBE2G2/PSMD7/NDUFS7/UBA52/ATF4/NDUFB7/NDUFS8/NDUFB10/ATP5F1A/UQCRC1/NDUFS6/PRKCB/TNF/WNT2/ATP5MC1/PLCB2/NDUFV1/LRRK2/ATXN1/RYR1/NDUFS1/MAP2K7/PSMD13/PIK3C3/COX4I2/RPS27A/GSK3B/NDUFA4L2/SLC25A4/RAF1/TOMM40/PPIF/TUBB4B/APP/HIP1/MAPK14/CAMK2G/SIGMAR1/DCTN5	1.98659549582899
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	24/960	158/9376	1.48354430379747	PIK3R1/CLIP1/PRKCB/TNF/WNT2/IKBKB/RICTOR/FNIP1/RPS6/IGF1R/LPIN2/SKP2/TSC2/MAPKAP1/GSK3B/LPIN1/SOS1/RAF1/PIK3R3/NPRL3/STRADA/RPS6KB2/RRAGB/INSR	2.07021215669053
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/960	103/9376	1.61197411003236	COL1A1/COL6A2/COL3A1/COL6A1/COL4A2/COL1A2/COL4A1/COL15A1/COL14A1/COL5A1/ATP1A1/SLC38A2/SLC8A1/DPP4/COL5A2/COL6A3/ELN	2.1091619271084
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	49/960	368/9376	1.30045289855072	MT-CYB/MT-ND4/MT-ND1/MT-CO3/MT-CO2/MT-ATP6/MT-ND2/MT-CO1/MT-ND5/MT-ND3/MT-ND4L/FUS/MT-ATP8/MT-ND6/COX4I1/GPX3/TPR/ATP5F1D/SETX/ANXA11/ATXN2/SRSF3/TNFRSF1B/RB1CC1/PSMD7/NDUFS7/HNRNPA2B1/ATF4/NDUFB7/NDUFS8/RANBP2/SRSF7/NDUFB10/ATP5F1A/UQCRC1/NDUFS6/TNF/ATP5MC1/NDUFV1/NDUFS1/PSMD13/PIK3C3/COX4I2/NDUFA4L2/TOMM40/TUBB4B/MAPK14/SIGMAR1/DCTN5	1.98588689565356
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/960	73/9376	1.73926940639269	AFF4/EP300/RANBP2/PSIP1/CCNT1/BICD1/BICD2/SERINC5/MDFIC/MAP1B/NELFCD/APOBEC3A/CCNT2	2.14151462573518
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	13/960	73/9376	1.73926940639269	HGF/FOXO3/PIK3R1/CDK6/PRKCB/EML4/EGFR/CDKN1A/RXRA/SOS1/RAF1/POLK/PIK3R3	2.14151462573518
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/960	59/9376	1.82090395480226	FOXO3/PIK3R1/APC/EGFR/CDKN1A/TCF7L2/GSK3B/SOS1/RAF1/POLK/PIK3R3	2.13623338205603
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/960	112/9376	1.56964285714286	HLA-DRB5/JAK1/HLA-DMB/IL10RA/LAMC1/ITGA6/JAK2/TNF/LAMB1/CIITA/IKBKB/LAMA2/LAMA4/BIRC3/LAMB2/PPIF/LAMC3/MAPK14	2.04823972788512
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/960	90/9376	1.62777777777778	JAK1/JUN/PIK3R1/PTPN6/JAK2/EML4/IKBKB/EGFR/MAP3K3/NFATC3/CD247/RAF1/PIK3R3/MAPK14/RPS6KB2	2.02106948405832
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/960	122/9376	1.52103825136612	JUN/PIK3R1/PTPN6/PTPRC/TNF/IKBKB/MAP2K7/NFATC3/FYN/DLG1/PPP2R2A/CD247/GSK3B/SOS1/RAF1/MAP3K14/PIK3R3/TEC1/MAPK14	1.95637978524263
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/960	122/9376	1.52103825136612	CSH1/ITPR2/IGFBP3/PIK3R1/CSH2/EP300/ATF4/CREB3L2/JAK2/PRKCB/PLCB2/CREB1/CREB3L1/ATF6B/GSK3B/SOS1/RAF1/PIK3R3/MAPK14	1.95637978524263
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	14/960	83/9376	1.64738955823293	EP300/MGA/ASXL2/PHC3/AUTS2/OGT/MTF2/ASXL1/MBD5/KDM2A/SFMBT2/USP7/MBD6/EZH1	2.00076075130697
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/960	91/9376	1.60989010989011	JUN/PIK3R1/PTPN6/LILRB5/LILRB3/PRKCB/LILRB2/IKBKB/RAC2/NFATC3/GSK3B/SOS1/RAF1/RASGRP3/PIK3R3	1.97446629363274
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/960	99/9376	1.57845117845118	NCOR1/JUN/PIK3R1/MMP2/HBEGF/EGFR/IGF1R/NOTCH2/CDKN1A/NCOA3/SOS1/RAF1/PIK3R3/MED1/MAPK14/RPS6KB2	1.95410960982989
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/960	155/9376	1.44924731182796	CD36/HLA-DRB5/ATP6V0D1/ATP6V0B/CD209/DYNC1H1/ATP6V0A1/TFRC/HLA-DMB/CORO1A/OLR1/NCF1/SEC61A1/THBS1/ITGAV/PIKFYVE/DYNC1LI2/PIK3C3/TLR6/C1R/MRC1/TCIRG1/TUBB4B	1.90471813371475
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/960	61/9376	1.76120218579235	ATP2B1/SLC40A1/ATP2B4/SLC11A2/ATP1A1/SLC8A1/TRPM7/SLC31A1/SLC39A4/ATP7A/SLC46A1	2.01438234258568
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/960	139/9376	1.47553956834532	ITPR2/KRT18/JUN/PIK3R1/MMP2/ATF4/CREB3L2/NCOA1/HBEGF/PLCB2/EGFR/CREB1/CREB3L1/NCOA3/ATF6B/KRT10/SOS1/KRT19/RAF1/FKBP5/PIK3R3	1.90764245356779
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/960	115/9376	1.52869565217391	ITPR2/AKAP13/FGFR1/ATF4/CREB3L2/MAFB/PRKCB/HBEGF/PLCB2/EGFR/CREB1/CREB3L1/CDKN1A/RXRA/ATF6B/ARHGEF1/RAF1/GATA3	1.92661132271056
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/960	205/9376	1.38162601626016	HLA-DRB5/VIM/RBPJ/TAPBP/JAK1/JUN/HLA-DMB/PIK3R1/CCND2/MAVS/PSMD7/CDK6/CD44/TNF/IRF3/IKBKB/ITGAL/SKP2/CDKN1A/MAP2K7/PSMD13/USP7/CD247/RUNX3/MAP3K14/POLK/TRAF5/PIK3R3/MAPK14	1.8658423615238
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/960	77/9376	1.64891774891775	JAK1/PIK3R1/CDK6/ARHGEF6/IKBKB/EGFR/CDKN1A/RAC2/SMAD2/RAF1/POLK/PIK3R3/RPS6KB2	1.93101337992532
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	40/960	300/9376	1.30222222222222	HGF/FLNA/MKNK1/DUSP6/HSPB1/JUN/TAOK1/MAP3K2/FGFR1/ATF4/NR4A1/RASA1/PRKCB/FLT1/TNF/PDGFRA/IKBKB/EGFR/IGF1R/AREG/MAP3K11/MAP3K3/MAP2K7/MAP3K20/RAC2/NFATC3/FGF7/SOS1/RAF1/MAP3K14/NF1/MAP3K4/RASGRP3/DUSP9/MAPK14/PPP5C/CACNB4/MAPK8IP3/IL1R1/INSR	1.79683488073541
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/960	70/9376	1.67428571428571	HGF/JUN/PIK3R1/ELOB/EP300/EPAS1/ETS1/CDKN1A/SLC2A1/SOS1/RAF1/PIK3R3	1.91240489145926
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	24/960	166/9376	1.41204819277108	ATP2B1/ITPR2/SLC25A6/ROCK1/MYL9/PPP1R12A/ROCK2/ATF4/CREB3L2/ATP2B4/ADRB2/PLCB2/ATP1A1/CREB1/CREB3L1/SLC8A1/MYLK/NFATC3/ATF6B/SLC25A4/RAF1/PPIF/PRKG1/INSR	1.80900861008967
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	17/960	110/9376	1.50939393939394	DCN/ROCK1/EMP3/NCOR1/TFRC/ZFYVE16/EP300/FBN1/TNF/BMP5/THBS1/SMAD5/PITX2/BMP4/SMAD2/HFE/RPS6KB2	1.81498215556428
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/960	71/9376	1.65070422535211	FOXO3/PRLR/PIK3R1/CGA/CCND2/TNFRSF11A/JAK2/GSK3B/SOS1/RAF1/PIK3R3/MAPK14	1.85875865510018
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	26/960	184/9376	1.38007246376812	NRP1/ROCK1/MYL9/PIK3R1/SRGAP3/ROCK2/PLXNB2/RASA1/SRGAP1/LRRC4/RAC2/NFATC3/FYN/EPHB3/SEMA6D/GSK3B/SLIT2/SEMA6A/ENAH/RAF1/SEMA3B/PIK3R3/CAMK2G/ABLIM1/SEMA3D/MYL5	1.75848513362453
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/960	120/9376	1.465	FOXO3/KIDINS220/JUN/PIK3R1/ATF4/ARHGDIA/BEX3/IKBKB/MAP3K3/MAP2K7/GSK3B/MATK/MAGED1/SOS1/RAF1/PIK3R3/MAPK14/CAMK2G	1.7314114860097
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	24/960	170/9376	1.37882352941176	HGF/GSTP1/ARID1A/ARID1B/PBRM1/PIK3R1/APC/CDK6/SMARCA4/PRKCB/WNT2/EGFR/SMARCC1/IGF1R/SMARCC2/CDKN1A/SMAD2/TCF7L2/GSK3B/SOS1/RAF1/POLK/PIK3R3/RPS6KB2	1.68342709414164
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/960	73/9376	1.60547945205479	HGF/PIK3R1/FGFR1/CDK6/PDGFRA/EGFR/IGF1R/CDKN1A/FGF7/RAF1/POLK/PIK3R3	1.75395206530256
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/960	122/9376	1.44098360655738	CD36/EEF2/FOXO3/PIK3R1/CREB3L2/CREB1/CREB3L1/IGF1R/PRKAG2/EEF2K/PPP2R2A/TSC2/CAMKK2/PFKFB2/PIK3R3/STRADA/RPS6KB2/INSR	1.6557928544214
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	25/960	181/9376	1.34898710865562	HLA-DRB5/LSP1/ATP6V0D1/ATP6V0B/CD209/ATP6V0A1/JAK1/HLA-DMB/IL10RA/CR1/EP300/ITGAX/JAK2/CORO1A/TNF/CIITA/CREB1/PIK3C3/TLR6/MRC1/TCIRG1/RAF1/PLK3/MAPK14/CAMK2G	1.60118383393003
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/960	44/9376	1.77575757575758	DYNC1H1/VAMP2/CREB3L2/ARHGDIA/CREB1/CREB3L1/DYNC1LI2/DCTN5	1.74194079415176
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	33/960	250/9376	1.2892	CYTH4/AP2S1/TFRC/RAB11FIP1/ZFYVE16/VPS28/USP8/WWP1/IL2RA/CBL/DNM1/PDGFRA/EHD4/FOLR3/EGFR/ARAP2/IGF1R/IQSEC1/IL2RG/SMAD2/RUFY2/AP2A1/AGAP3/EHD2/RAB11FIP2/VPS25/MVB12A/ACAP1/EHD1/VPS37B/ARFGAP1/RBSN/EPN2	1.56529591572968
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/960	99/9376	1.47979797979798	TPM1/ITGA6/TNF/ITGA4/TPM2/LAMA2/TTN/SLC8A1/DES/ITGAV/PRKAG2/TNNT2/ITGA1/EMD/CACNB4	1.62084178929429
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/960	157/9376	1.36857749469214	CD36/STAB1/LRP1/BSG/PTPN6/TMEM30A/JAK2/MFGE8/CREB1/THBS1/DNMT3A/ITGAV/PROS1/VPS8/RXRA/NFATC3/SLC2A1/ATP11A/CD24/TGFBRAP1/MAPK14/CAMK2G	1.57291452797192
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/960	76/9376	1.54210526315789	PIK3R1/CDK6/PRKCB/PDGFRA/EGFR/IGF1R/CDKN1A/SOS1/RAF1/POLK/PIK3R3/CAMK2G	1.60257121185941
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/960	53/9376	1.65849056603774	ATP2B1/AP2S1/ATP2B4/DNM1/PRKCB/PLCB2/ATP1A1/SLC8A1/AP2A1	1.62359625673423
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/960	31/9376	1.89032258064516	SEC62/SRP72/SEC63/OXA1L/SEC61A1/TMEM208	1.67689926204053
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/960	160/9376	1.34291666666667	HLA-DRB5/VCAN/HLA-DMB/SELPLG/PTPRC/GLG1/JAML/ITGA6/CADM3/ITGA4/VSIR/LRRC4/ITGAL/SPN/ITGAV/ALCAM/PTPRM/SLITRK4/CADM1/PTPRD/ICAM3/NFASC	1.47756210115235
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/960	144/9376	1.35648148148148	IL6ST/ZFHX3/JAK1/RIF1/PIK3R1/APC/FGFR1/KAT6A/REST/JAK2/WNT2/IGF1R/SMAD5/BMP4/SMAD2/GSK3B/RAF1/PIK3R3/DUSP9/MAPK14	1.4559240278593
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/960	86/9376	1.47635658914729	GJA1/ITGA6/DSC2/ITGA4/LAMA2/DSP/SLC8A1/DES/ITGAV/TCF7L2/ITGA1/EMD/CACNB4	1.49879396898675
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/960	78/9376	1.5025641025641	HLA-DRB5/JAK1/JUN/HLA-DMB/CR1/PTPN6/JAK2/PRKCB/TNF/ITGA4/NCF1/MAPK14	1.50526299807868
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/960	95/9376	1.43929824561404	HLA-DRB5/ATP6V0D1/ATP6V0B/ATP6V0A1/JUN/HLA-DMB/CCL5/TNFRSF11A/ACP5/FLT1/TNF/LTB/ITGAL/TCIRG1	1.45342382993977
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/960	87/9376	1.45938697318008	MT-CYB/MT-CO3/MT-CO2/MT-CO1/COX4I1/TPM1/UQCRC1/TPM2/ATP1A1/SLC8A1/COX4I2/TNNT2/CACNB4	1.4538587411578
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/960	137/9376	1.35450121654501	CFLAR/ATM/ITPR2/JUN/PIK3R1/MCL1/ATF4/TNF/IKBKB/BIRC3/DFFA/CTSW/SPTAN1/GZMB/RAF1/MAP3K14/PIK3R3/PRF1/CTSO	1.41167239170544
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	21/960	154/9376	1.33181818181818	EEF2/ITPR2/ROCK1/MYL9/PPP1R12A/JUN/ROCK2/PRKCB/PLCB2/EGFR/RYR1/MYLK/CDKN1A/PRKAG2/EEF2K/NFATC3/CAMKK2/RAF1/CAMK2G/CACNB4/PPP1R12B	1.40222069380668
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/960	105/9376	1.3952380952381	CFLAR/ATM/TNFRSF11A/PRKCB/TNF/IKBKB/LTB/CYLD/BIRC3/LTBR/ERC1/MAP3K14/TRAF5/EDA/IL1R1	1.37549351746728
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/960	105/9376	1.3952380952381	LSP1/ITPR2/CD209/JUN/PIK3R1/TNF/IKBKB/CYLD/NFATC3/RAF1/MAP3K14/PLK3/PIK3R3/MAPK14/EGR2	1.37549351746728
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/960	12/9376	2.44166666666667	CD209/CD46/NPC1	1.68769191122016
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	20/960	148/9376	1.31981981981982	JUN/PIK3R1/APC/FGFR1/CDK6/NCOA1/WNT2/EGFR/IGF1R/NOTCH2/CDKN1A/NCOA3/FGF7/TCF7L2/GSK3B/SOS1/RAF1/POLK/PIK3R3/RPS6KB2	1.3244965468155
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/960	89/9376	1.42659176029963	ITPR2/MAP3K2/GJA1/PRKCB/CSNK1D/PDGFRA/PLCB2/EGFR/SOS1/RAF1/TUBB4B/TJP1/PRKG1	1.3656459923995
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/960	19/9376	2.05614035087719	DHTKD1/OGDH/PDHB/DBT	1.55631861712936
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/960	149/9376	1.31096196868009	MT-ND4/MT-ND1/MT-ND2/MT-ND5/MT-ND3/MT-ND4L/MT-ND6/ITPR2/NDUFS7/NDUFB7/NDUFS8/NDUFB10/GNG2/NDUFS6/PRKCB/PLCB2/NDUFV1/NDUFS1/NDUFA4L2/MAPK14	1.29222620055119
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/960	34/9376	1.72352941176471	PER3/CSNK1D/PER1/CREB1/PRKAG2/RORA	1.42739479386187
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/960	66/9376	1.47979797979798	HLA-DRB5/JUN/HLA-DMB/TNF/STAT6/IL2RG/SMAD2/RORA/IL4R/GATA3	1.32106423043745
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/960	50/9376	1.56266666666667	CD36/HBB/HGF/LRP1/CR1/TNF/ITGAL/THBS1	1.34727693700475
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/960	134/9376	1.31194029850746	CALD1/ITPR2/ROCK1/MYL9/PLA2G2A/PPP1R12A/ROCK2/MYH9/MYH10/PRKCB/PLCB2/MYLK/PPP1R14A/ACTA2/ARHGEF1/RAF1/PRKG1/PPP1R12B	1.22831368879038
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/960	13/9376	2.25384615384615	PRKDC/XRCC6/POLL	1.52783624236503
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/960	75/9376	1.43244444444444	GSTP1/ATM/PIK3R1/TOP2B/REV3L/XPA/BIRC3/CDKN1A/SLC31A1/ATP7A/PIK3R3	1.26988537919606
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/960	75/9376	1.43244444444444	ATM/MDM4/IGFBP3/CCND2/CDK6/ZMAT3/ZNF385A/THBS1/CDKN1A/SIVA1/TSC2	1.26988537919606
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/960	75/9376	1.43244444444444	GPX3/ITPR2/CGA/ATF4/CREB3L2/PRKCB/PLCB2/ATP1A1/CREB1/CREB3L1/ATF6B	1.26988537919606
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/960	67/9376	1.45771144278607	LDHB/PKM/ADPGK/ACSS1/GPI/ALDH3B1/PDHB/GALM/ALDH2/HK1	1.26983135750707
Organismal Systems	Immune system	hsa04611	Platelet activation	17/960	126/9376	1.31772486772487	COL1A1/COL3A1/ITPR2/ROCK1/COL1A2/PPP1R12A/TLN1/PIK3R1/ROCK2/PLCB2/MYLK/ARHGAP35/FYN/ARHGEF1/PIK3R3/MAPK14/PRKG1	1.21264590650343
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	31/960	250/9376	1.21106666666667	VPS13C/ATP6V0D1/ATP6V0B/AP2S1/TPP1/ATP6V0A1/DMXL2/SLC11A1/MCOLN1/TPCN1/SLC11A2/ACP5/CLN6/GGA1/GPR155/PIKFYVE/HGSNAT/BORCS7/CTSW/IDS/AP2A1/VPS13A/TCIRG1/NPC1/CLN8/ROGDI/AP1M1/KXD1/CTSO/RRAGB/CLCN7	1.14239900165979
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/960	180/9376	1.24796296296296	HLA-DRB5/POU2F2/TAPBP/JAK1/SRSF5/HLA-DMB/SRSF3/PIK3R1/CCL5/MAVS/SRSF7/TNFRSF14/JAK2/TNF/IRF3/IKBKB/BIRC3/POU2F1/SRSF6/CFP/TSC2/TRAF5/PIK3R3	1.13446729347872
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/960	52/9376	1.5025641025641	CD36/APOE/APOC1/LRP1/TSPO/LRPAP1/PLTP/NPC1	1.2273273014202
Genetic Information Processing	Transcription	hsa03040	Spliceosome	30/960	243/9376	1.20576131687243	RBM25/FUS/TRA2B/PRPF38B/DDX46/SF1/SNRNP70/HNRNPU/SF3B1/U2SURP/THOC2/SRSF5/SRSF3/RBMX/SNRPD2/SRSF10/SRSF7/DDX39B/HNRNPM/TCERG1/LSM7/PRPF6/SNRNP200/DDX42/SRSF6/CCDC12/PQBP1/CWC25/DHX38/CASC3	1.09756065458147
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/960	69/9376	1.41545893719807	PIK3R1/ALOX5AP/TNF/MAP2K7/RAC2/FYN/SOS1/RAF1/PIK3R3/MAPK14	1.16981230557535
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/960	103/9376	1.32750809061489	FUS/SRRM1/PNN/SMG1/PABPC4/UPF2/DDX39B/WDR82/PCF11/CPSF2/PPP2R2A/UPF3B/ETF1/CASC3	1.12875297209609
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/960	138/9376	1.27391304347826	FN1/ROCK1/WASF2/JUN/PIK3R1/ROCK2/TNF/ITGA4/IRF3/IKBKB/MAP2K7/RAC2/NFATC3/GSK3B/ARHGEF1/PIK3R3/MAPK14/PTK2B	1.09479213556395
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/960	174/9376	1.23486590038314	RRBP1/UBXN4/SEC62/SEC63/UBE2G2/PRKCSH/ATF4/SEC31A/PPP1R15A/BCAP31/MAN1A2/CKAP4/STUB1/SEC61A1/MAP2K7/WFS1/ATF6B/GANAB/MBTPS1/MAN1B1/NPLOC4/TUSC3	1.05614091649363
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/960	62/9376	1.41774193548387	FOXO3/PIK3R1/IGF1R/PRKAG2/PIK3R3/EIF4EBP2/CLPB/RPS6KB2/INSR	1.11456190186205
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/960	157/9376	1.24416135881104	ATM/ITPR2/SLC25A6/FOXO3/IGFBP3/PIK3R1/CCND2/ZFP36L2/CDK6/HIPK3/ETS1/CDKN1A/TRPM7/NFATC3/SMAD2/TSC2/SLC25A4/RAF1/PIK3R3/MAPK14	1.04196526910582
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/960	105/9376	1.30222222222222	TPM1/ITGA6/TNF/ITGA4/TPM2/LAMA2/TTN/SLC8A1/DES/ITGAV/TNNT2/ITGA1/EMD/CACNB4	1.05178299488261
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/960	98/9376	1.29557823129252	ITPR2/PIK3R1/DGKZ/PRKCB/DGKH/PLCB2/PIKFYVE/PIK3C3/PIK3C2A/PIK3R3/IPMK/INPP5B/SACM1L	0.99340579956808
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/960	98/9376	1.29557823129252	ATP2B1/ITPR2/ATF4/CREB3L2/ATP2B4/NR4A1/PRKCB/PLCB2/ATP1A1/CREB1/CREB3L1/ATF6B/CAMK2G	0.99340579956808
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/960	47/9376	1.45460992907801	PKM/PIK3R1/TNF/IKBKB/PIK3R3/HK1/INSR	1.05520949543249
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/960	107/9376	1.27788161993769	ITPR2/LDHB/PKM/EP300/ATF4/CREB3L2/PHKB/PLCB2/CREB1/CREB3L1/PRKAG2/SLC2A1/PDHB/CAMK2G	0.976345797023539
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/960	169/9376	1.21360946745562	VMP1/CFLAR/TAX1BP1/PIK3R1/RB1CC1/BIRC6/UBA52/GABARAPL1/ATG4B/IGF1R/ATG16L2/UVRAG/ATG7/PIK3C3/RPS27A/TSC2/CAMKK2/RAF1/PIK3R3/RPS6KB2/RRAGB	0.946396595533552
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	22/960	178/9376	1.20711610486891	JUN/SERPINF1/APC/CCND2/EP300/ROCK2/CHD8/PRKCB/WNT2/PLCB2/RAC2/NFATC3/TCF7L2/GSK3B/TBL1X/RSPO2/FRZB/TLE3/CCDC88C/RSPO3/CAMK2G/NOTUM	0.942205336731872
NA	NA	hsa04981	Folate transport and metabolism	5/960	31/9376	1.5752688172043	MTHFR/FOLR3/MTR/ABCC5/SLC46A1	1.0835037502315
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/960	65/9376	1.35230769230769	ITPR2/PIK3R1/CGA/SPP1/PRKCB/PLCB2/RAF1/PIK3R3/KISS1	0.9626070365766
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/960	216/9376	1.17561728395062	CD36/POU2F2/JUN/PIK3R1/CCL5/ROCK2/ATF4/JAK2/OLR1/TNF/NCF1/IRF3/PLCB2/IKBKB/MIB1/MAP2K7/POU2F1/RXRA/NFATC3/TLR6/GSK3B/ARHGEF1/PIK3R3/MAPK14/CAMK2G/HSPA2	0.88189074768063
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/960	144/9376	1.22083333333333	RBPJ/ITPR2/SLC25A6/ATXN2/PIK3R1/RB1CC1/PSMD7/PRKCB/PLCB2/ATXN1/RYR1/PSMD13/PIK3C3/AFG3L2/RORA/SLC25A4/PPIF/PIK3R3	0.901916573102452
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/960	32/9376	1.52604166666667	HADHA/LDHB/ACSS1/ECHDC1/DBT	1.00669314347783
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/960	49/9376	1.3952380952381	FOSB/JUN/ATF4/CREB3L2/CREB1/CREB3L1/ATF6B	0.936815872928126
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/960	41/9376	1.42926829268293	MMP2/HBEGF/EGFR/THBS1/CDKN1A/RAF1	0.930319169097056
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/960	201/9376	1.16616915422886	FUS/REL/JMJD1C/ATM/KMT2A/NUPR1/DUSP6/NCOR1/IGFBP3/EWSR1/CCND2/TAF15/FLT1/PROM1/CCNT1/IGF1R/BIRC3/CDKN1A/RXRA/HPGD/SPINT1/GZMB/POLK/CCNT2	0.804292081484576
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/960	138/9376	1.20314009661836	MKNK1/PIK3R1/PRKAR2A/CBL/PHKB/IKBKB/RPS6/PRKAG2/EXOC7/TSC2/GSK3B/SOS1/RAF1/PIK3R3/HK1/RPS6KB2/INSR	0.811922562618417
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/960	33/9376	1.47979797979798	IDH3B/DHTKD1/OGDH/PDHB/DBT	0.932482310520103
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	29/960	248/9376	1.14206989247312	AHNAK/FLNA/CYTH4/S100A10/MYL9/DYNC1H1/ANXA2/JUN/GCC2/ROCK2/PTPRC/RPS3/TNF/IKBKB/BIRC3/GSDMD/MAP2K7/DYNC1LI2/PIK3C3/TLR6/EXOC7/TCF7L2/EXOC4/PIK3C2A/RAF1/TUBB4B/MAPK14/DCTN5/MYL5	0.76578784336999
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/960	103/9376	1.23268608414239	CFLAR/JUN/PIK3R1/CCL5/TNF/PLCB2/IKBKB/TLR6/SMAD2/PPP2R2A/CD247/PIK3R3/MAPK14	0.801949987091983
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	25/960	212/9376	1.15172955974843	HGF/TLN1/PIK3R1/EVL/FGFR1/PRKCB/FLT1/PDGFRA/PLCB2/EGFR/ITGAL/TIAM1/IGF1R/THBS1/KRIT1/RAC2/FGF7/ENAH/RAF1/RAPGEF6/RASGRP3/PIK3R3/MAGI1/MAPK14/INSR	0.754681978286299
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/960	194/9376	1.15790378006873	TPM1/MYO1F/MYL9/HOOK3/DYNC1H1/MYO5A/MYO9B/MYH9/MYH10/KIF20B/TPM2/TNNT3/MYO9A/DYNC1LI2/MYO1G/MYO7A/ACTA2/TNNT2/TUBB4B/KIF3B/KIF22/DCTN5/MYL5	0.750573347567922
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/960	86/9376	1.24922480620155	VAMP2/ATF4/CREB3L2/PRKCB/PLCB2/ATP1A1/CREB1/CREB3L1/SLC2A1/ATF6B/CAMK2G	0.784153394677364
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/960	214/9376	1.14096573208723	ATM/ITPR2/TAPBP/JUN/PIK3R1/ELOB/TNFRSF1B/GNG2/PRKCB/TNF/IRF3/IKBKB/MAP2K7/DDB1/RAC2/NFATC3/CD247/RAF1/APOBEC3A/TRAF5/PIK3R3/AP1M1/MAPK14/PTK2B/RPS6KB2	0.704520582344527
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/960	69/9376	1.27391304347826	FOSB/JUN/ATF4/CREB3L2/PRKCB/CREB1/CREB3L1/ATF6B/CAMK2G	0.771259973559562
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	23/960	196/9376	1.14608843537415	IL6ST/ITPR2/JAK1/JUN/PIK3R1/EP300/UBA52/CDK6/GNG2/JAK2/IRF3/IKBKB/CREB1/CDKN1A/MAP2K7/PIK3C3/NFATC3/RPS27A/TCF7L2/GSK3B/RAF1/PIK3R3/MAPK14	0.698057060538209
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/960	105/9376	1.20920634920635	FOXO3/TAX1BP1/JUN/USP8/UBA52/ATF4/GABARAPL1/PHB2/HUWE1/MON1B/RPS27A/TOMM40/RHOT2	0.728072472297941
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/960	187/9376	1.14901960784314	ITPR2/JAK1/JUN/CCL5/MAVS/GABARAPL1/TNF/IRF3/PLCB2/IKBKB/NAMPT/P2RX7/BIRC3/GSDMD/TRPM7/DNM1L/PSTPIP1/ANTXR2/NLRP1/TRAF5/ANTXR1/MAPK14	0.695181946194413
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/960	133/9376	1.1749373433584	SH3BP2/PIK3R1/PTPN6/PRKCB/TNF/ITGAL/CD48/RAC2/FYN/CD247/SOS1/GZMB/RAF1/PIK3R3/PRF1/PTK2B	0.686230887981877
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/960	70/9376	1.25571428571429	CD36/TNFRSF1B/JAK2/TNF/IKBKB/PRKAG2/RXRA/SLC2A1/CAMKK2	0.725255244854252
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/960	70/9376	1.25571428571429	HLA-DRB5/HLA-DMB/CD55/LAMA2/ITGAL/RAC2/FYN/PRF1/ABL2	0.725255244854252
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/960	170/9376	1.14901960784314	ROCK1/MYL9/JUN/EZR/ROCK2/MYH9/ACTN4/MYH10/YBX3/TIAM1/RAB13/PRKAG2/MAP2K7/DLG1/PPP2R2A/ARHGEF2/ACTN1/RAPGEF6/MAGI1/TJP1	0.662217697488431
NA	NA	hsa04519	Cadherin signaling	45/960	404/9376	1.08787128712871	VIM/MYO1F/ROCK1/KRT18/PCDH12/TAOK1/APC/EVL/FGFR1/KRT7/EP300/KRT8/GJA1/ROCK2/RERE/ACTN4/DSC2/TMC6/WNT2/PDGFRA/IKBKB/EGFR/FMN1/DSP/VCL/CDH11/IGF1R/DES/ARHGAP35/LIMA1/ABI2/RAC2/MYO1G/TMC8/MYO7A/TCF7L2/GSK3B/KRT10/KRT19/ENAH/RAF1/ACTN1/MAPK14/PTK2B/TJP1	0.609763507165967
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/960	27/9376	1.44691358024691	TECR/ACAA1/ELOVL1/FADS1	0.785400629746164
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/960	144/9376	1.15300925925926	TRA2B/FOXO3/TNF/IRF3/IKBKB/LPIN2/C5AR1/PRKAG2/MAP2K7/TCF7L2/CAMKK2/GSK3B/LPIN1/IL17RA/ALDH2/MAP3K14/MAPK14	0.624912845724026
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/960	200/9376	1.12316666666667	CYTH4/MYO1F/ROCK1/WASF2/NCL/MYO5A/JUN/EZR/ROCK2/PTPN6/RPS3/MYH9/MYH10/TNF/IKBKB/MYO1G/FYN/ARHGEF2/ARHGEF1/TUBB4B/MAPK14/TJP1/IL1R1	0.594634187621032
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	18/960	154/9376	1.14155844155844	ATP2B1/TPM1/ATF4/CREB3L2/ATP2B4/ADRB2/TPM2/PLCB2/ATP1A1/CREB1/CREB3L1/SLC8A1/PPP2R2A/ATF6B/TNNT2/MAPK14/CAMK2G/CACNB4	0.598207654109309
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/960	54/9376	1.26604938271605	LDHB/AHCYL1/DNMT1/MTR/DNMT3A/GCLC/AHCY	0.662175300879804
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	20/960	173/9376	1.12909441233141	HLA-DRB5/SLC25A6/JAK1/HLA-DMB/PIK3R1/CCL5/EP300/MAVS/CDK6/JAK2/HNRNPUL1/PRKCB/KPNA6/TNF/IRF3/CIITA/IKBKB/SLC25A4/RAF1/PIK3R3	0.578807535701418
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	18/960	155/9376	1.1341935483871	KMT2A/ITPR2/APC/USP8/ATF4/CREB3L2/NR4A1/CDK6/WNT2/PLCB2/EGFR/CREB1/CREB3L1/CDKN1A/ATF6B/TCF7L2/GSK3B/CAMK2G	0.5689536215596
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/960	37/9376	1.31981981981982	HBB/PRKCB/TNF/PLCB2/LAMA4	0.65830088647139
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/960	37/9376	1.31981981981982	TPR/CDKN1A/RXRA/TCF7L2/POLK	0.65830088647139
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/960	65/9376	1.20205128205128	ITPR2/ATF4/CREB3L2/NR4A1/PLCB2/CREB1/CREB3L1/ATF6B	0.552062841937671
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/960	38/9376	1.28508771929825	ENPP1/NT5C/NAMPT/QPRT/NAPRT	0.594718932855398
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/960	38/9376	1.28508771929825	PIK3R1/PRKCB/ATP1A1/PIK3R3/INSR	0.594718932855398
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/960	12/9376	1.62777777777778	COQ7/COQ4	0.734910157872363
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	18/960	158/9376	1.1126582278481	ATRX/NIPBL/ATM/PRKDC/CDKN1C/CCND2/SMC1A/EP300/ANAPC5/CDK6/WAPL/SKP2/CDKN1A/PDS5A/SMAD2/GSK3B/CCNH/ANAPC7	0.482326916087585
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/960	21/9376	1.3952380952381	CSGALNACT1/CHSY1/CHPF	0.612371457893405
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/960	21/9376	1.3952380952381	ENPP1/ALDH2/COASY	0.612371457893405
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/960	48/9376	1.22083333333333	HADHA/IVD/ACAA1/ACSF3/DBT/ALDH2	0.518035317539033
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/960	48/9376	1.22083333333333	PIK3R1/PRKCB/PLCB2/ATP1A1/PIK3R3/HK1	0.518035317539033
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/960	39/9376	1.25213675213675	HLA-DRB5/HLA-DMB/TNF/GZMB/PRF1	0.532884600058279
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/960	77/9376	1.14155844155844	PIK3R1/CDK6/CBL/IKBKB/CDKN1A/SOS1/RAF1/POLK/PIK3R3	0.421241744653489
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	26/960	238/9376	1.06694677871148	HGF/REL/PLA2G2A/PIK3R1/FGFR1/GNG2/RASA1/PRKCB/FLT1/ETS1/PDGFRA/IKBKB/EGFR/TIAM1/IGF1R/RAC2/FGF7/SOS1/RAF1/RALGAPA2/NF1/RASGRP3/PIK3R3/ABL2/RGL2/INSR	0.35331410674174
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/960	31/9376	1.26021505376344	TKT/GPI/PGD/H6PD	0.490108238422474
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/960	22/9376	1.33181818181818	AOC1/ALDH3B1/ALDH2	0.526236815749898
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/960	68/9376	1.14901960784314	DUSP6/PIK3R1/IKBKB/TCF7L2/SOS1/RAF1/PIK3R3/RPS6KB2	0.416522126101304
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/960	115/9376	1.10405797101449	ITPR2/PIK3R1/ATF4/CREB3L2/GNG2/JAK2/PRKCB/PLCB2/CREB1/CREB3L1/FYN/PIK3R3/CAMK2G	0.379195978537878
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/960	59/9376	1.15875706214689	PIK3R1/CGA/ADRB2/PNPLA2/PIK3R3/PRKG1/INSR	0.413132539819507
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/960	32/9376	1.22083333333333	GABARAPL1/ATG4B/ATG7/PIK3C3	0.422611775083764
Human Diseases	Immune disease	hsa05310	Asthma	4/960	32/9376	1.22083333333333	HLA-DRB5/HLA-DMB/TNF/PRG2	0.422611775083764
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/960	60/9376	1.13944444444444	HSPB1/PIK3R1/PRKCB/RAC2/RAF1/PIK3R3/MAPK14	0.365957365898481
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/960	60/9376	1.13944444444444	ITPR2/PRKCB/PLCB2/IGF1R/RYR1/RAF1/PRKG1	0.365957365898481
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/960	79/9376	1.1126582278481	ATP6V0D1/ATP6V0B/AP2S1/ATP6V0A1/VAMP2/SYT1/DNM1/AP2A1/TCIRG1	0.33960450040328
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/960	136/9376	1.07720588235294	CD209/JAK1/JUN/PIK3R1/CCND2/MAVS/IL2RA/CDK6/CD46/RACK1/IRF3/IKBKB/IL2RG/GSK3B/PIK3R3	0.306303705420041
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/960	51/9376	1.14901960784314	ATP6V0D1/ATP6V0B/ATP6V0A1/SEC61A1/TCIRG1/TJP1	0.360389787159624
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/960	108/9376	1.08518518518519	TPR/SRRM1/PNN/THOC2/UPF2/RANBP2/DDX39B/KPNA6/IPO9/UPF3B/IPO8/CASC3	0.300712394167001
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/960	42/9376	1.16269841269841	HADHA/AOC1/INMT/DHTKD1/ALDH2	0.356896635779098
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/960	42/9376	1.16269841269841	TFRC/SLC40A1/SLC11A2/ATG7/GCLC	0.356896635779098
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/960	109/9376	1.07522935779817	JAK1/JUN/PIK3R1/CCL5/SPP1/TNF/IRF3/IKBKB/MAP2K7/TLR6/PIK3R3/MAPK14	0.266808347626105
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/960	100/9376	1.07433333333333	CXCL14/IL6ST/TNFRSF1B/CCL5/IL10RA/IL2RA/TNFRSF14/IL6R/TNF/LTBR/IL2RG	0.252389701303934
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/960	62/9376	1.10268817204301	RBPJ/SPEN/EP300/MAML2/ATXN1/NOTCH2/TLE3	0.27397853700856
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/960	149/9376	1.04876957494407	CYTH4/PIK3R1/DGKZ/DNM1/DGKH/PDGFRA/PLCB2/EGFR/FYN/PLPP3/TSC2/SOS1/RAF1/PIK3R3/PTK2B/INSR	0.202665691885007
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/960	72/9376	1.08518518518519	DDX3X/MAVS/TNF/IRF3/RNF125/IKBKB/CYLD/MAPK14	0.245055165004558
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/960	101/9376	1.06369636963696	EP300/CREB3L2/PRKCB/WNT2/PLCB2/CREB1/CREB3L1/TCF7L2/GSK3B/RAF1/CAMK2G	0.217363590623369
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/960	63/9376	1.08518518518519	APC/WNT2/CDKN1A/BMP4/TCF7L2/GSK3B/POLK	0.229117328301575
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/960	150/9376	1.04177777777778	HGF/PIK3R1/APC/WNT2/EGFR/CDKN1A/RXRA/SMAD2/FGF7/TCF7L2/GSK3B/SOS1/RAF1/POLK/PIK3R3/RPS6KB2	0.174201797193395
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/960	44/9376	1.10984848484848	TAF15/TAF3/TAF1/TAF7/CCNH	0.246661538234379
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/960	44/9376	1.10984848484848	APEX1/POLL/PARG/PNKP/MPG	0.246661538234379
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/960	44/9376	1.10984848484848	HLA-DRB5/HLA-DMB/TNF/GZMB/PRF1	0.246661538234379
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/960	93/9376	1.05017921146953	LYZ/ATP2B1/ITPR2/VAMP2/ATP2B4/PRKCB/ADRB2/PLCB2/ATP1A1/PRKG1	0.164244003580037
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/960	142/9376	1.03169014084507	GSTP1/JUN/PIK3R1/MMP2/TNF/NCF1/IKBKB/ITGAV/MAP2K7/RAC2/BMP4/ARHGEF2/PIK3R3/MAPK14/IL1R1	0.128511442310106
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/960	45/9376	1.08518518518519	HLA-DRB5/HLA-DMB/TNF/GZMB/PRF1	0.193452624204973
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/960	94/9376	1.03900709219858	FOSB/JUN/S100A9/ANAPC5/TNF/IKBKB/GSK3B/IL17RA/TRAF5/MAPK14	0.128367508765748
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/960	65/9376	1.05179487179487	DGKZ/DGKH/LPIN2/PLPP3/LPIN1/ALDH2/PNPLA2	0.141518647298743
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/960	26/9376	1.12692307692308	ABCD4/SLC19A3/SLC46A1	0.218871821270366
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/960	36/9376	1.08518518518519	ENPP1/GPI/AGL/HK1	0.172945901878596
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	20/960	193/9376	1.01208981001727	CXCL14/FOXO3/ROCK1/PIK3R1/CCL5/ROCK2/GNG2/JAK2/PRKCB/NCF1/PLCB2/IKBKB/TIAM1/FGR/RAC2/GSK3B/SOS1/RAF1/PIK3R3/PTK2B	0.0573157830259519
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/960	56/9376	1.04642857142857	MAN1A2/GANAB/MAN1B1/DPM2/DPM3/TUSC3	0.117690056029175
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/960	56/9376	1.04642857142857	CCND2/MGRN1/CSNK1D/DISP1/GSK3B/MEGF8	0.117690056029175
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/960	17/9376	1.14901960784314	INMT/MTR	0.207692849381593
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/960	254/9376	0.999737532808399	HGF/ATP2B1/ITPR2/SLC25A6/MCOLN1/FGFR1/HRH1/TPCN1/ATP2B4/PHKB/PRKCB/FLT1/ADRB2/PDGFRA/PLCB2/EGFR/P2RX7/RYR1/SLC8A1/MYLK/NFATC3/FGF7/SLC25A4/PPIF/CAMK2G/PTK2B	-0.00143223815761855
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/960	47/9376	1.03900709219858	LDHB/PKM/ACSS1/PDHB/ALDH2	0.0905405963319608
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/960	57/9376	1.0280701754386	HADHA/TECR/ACAA1/ACSF3/ELOVL1/FADS1	0.0717903863023745
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/960	156/9376	1.0017094017094	CFLAR/JAK1/PIK3R1/MAVS/CDK6/TNF/IRF3/IKBKB/EGFR/CDKN1A/RXRA/PPP2R2A/GSK3B/SOS1/RAF1/PIK3R3	0.00727125480643171
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/960	67/9376	1.02039800995025	ITPR2/EP300/ATF4/PRKCB/PLCB2/RAF1/CAMK2G	0.0565903104975978
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/960	78/9376	1.0017094017094	PLCB2/ISYNA1/PIKFYVE/PIK3C3/PIK3C2A/IPMK/INPP5B/SACM1L	0.00511994217033574
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/960	78/9376	1.0017094017094	BTG1/DHX36/PABPC4/LSM7/DCP2/CNOT2/CNOT1/DIS3L	0.00511994217033574
NA	NA	hsa03272	Virion - Hepatitis viruses	5/960	48/9376	1.01736111111111	TGOLN2/CD9/EGFR/DPP4/HSPG2	0.040726046976339
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/960	98/9376	0.996598639455782	WASF2/PIK3R1/PTPRC/PRKCB/NCF1/RAC2/PLPP3/RAF1/PIK3R3/RPS6KB2	-0.0114315972332342
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/960	28/9376	1.04642857142857	HADHA/TECR/ELOVL1	0.0830947099253895
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/960	28/9376	1.04642857142857	ATP6V0D1/ATP6V0A1/TCIRG1	0.0830947099253895
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/960	18/9376	1.08518518518519	MAN2B2/MAN2C1	0.122173550543115
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/960	18/9376	1.08518518518519	ABCD4/MTR	0.122173550543115
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/960	99/9376	0.986531986531986	HLA-DRB5/KRT18/HLA-DMB/SELPLG/ITGAL/C5AR1/C1R/KRT10/KRT19/C1S	-0.0454973133836994
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/960	39/9376	1.0017094017094	AHCYL1/MTHFR/MTR/AHCY	0.0036127769495477
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/960	140/9376	0.976666666666667	ITPR2/GNG2/SPP1/PLCB2/RPS6/RYR1/SLC8A1/MYLK/PRKAG2/PIK3C3/SMAD2/ACTA2/RAF1/RPS6KB2	-0.0939436072723846
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/960	50/9376	0.976666666666667	HLA-DRB5/HLA-DMB/ITGA4/LTBR/MAP3K14	-0.0558704890937989
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/960	19/9376	1.0280701754386	HGSNAT/IDS	0.0413639499569265
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/960	30/9376	0.976666666666667	IDH3B/OGDH/PDHB	-0.0432307644888507
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/960	82/9376	0.952845528455285	HLA-DRB5/TAPBP/HLA-DMB/TNF/CIITA/CREB1/IFI30/HSPA2	-0.144842784609923
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/960	133/9376	0.954636591478697	ITPR2/ATF4/CREB3L2/GNG2/PRKCB/PLCB2/CREB1/CREB3L1/PPP2R2A/ATF6B/GSK3B/MAPK14/CAMK2G	-0.177948124247449
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/960	195/9376	0.951623931623932	SLC25A6/PIK3R1/CR1/SELPLG/CLCN5/PRKCB/NCF1/PLCB2/ITGAL/C5AR1/GSDMD/ATG7/RAC2/HDAC7/SLC25A4/RAF1/PPIF/PIK3R3/MAPK14	-0.230553262793958
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/960	52/9376	0.939102564102564	CGA/HSD17B2/HSD17B1/IGF1R/INSR	-0.148719507187397
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/960	31/9376	0.945161290322581	HADHA/ALDH3B1/ALDH2	-0.103287273386555
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	22/960	226/9376	0.950737463126844	ATP2B1/ROCK1/MYL9/PPP1R12A/JUN/PIK3R1/CGA/EP300/ROCK2/CREB3L2/ATP2B4/ADRB2/ATP1A1/CREB1/TIAM1/CREB3L1/RAC2/FXYD1/VIPR2/RAF1/PIK3R3/CAMK2G	-0.253179674278715
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/960	125/9376	0.9376	ROCK1/PIK3R1/ROCK2/PRKCB/TNF/PLCB2/RAC2/FYN/PPP2R2A/RAF1/PIK3R3/MAPK14	-0.237199433253689
NA	NA	hsa04382	Cornified envelope formation	21/960	217/9376	0.945161290322581	S100A6/S100A4/S100A10/COL4A2/KRT18/COL4A1/KRT7/DST/KRT8/S100A9/ITGA6/S100A1/PLEC/DSP/PPP2R2A/ELOVL1/S100A13/KRT10/KRT19/SLC27A1/TJP1	-0.276033286523012
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	21/960	217/9376	0.945161290322581	JUN/PIK3R1/ATF4/CREB3L2/EPHX1/JAK2/PRKCB/KPNA6/ADRB2/EGFR/CREB1/CREB3L1/NOTCH2/RXRA/FGF7/ATF6B/SOS1/RAF1/PAQR7/PIK3R3/RPS6KB2	-0.276033286523012
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/960	298/9376	0.950447427293065	CSH1/CXCL14/IL6ST/PRLR/TNFRSF25/TNFRSF1B/CSH2/CSF3R/CCL5/IL10RA/IL1RL1/IL2RA/TNFRSF14/TNFRSF11A/IL6R/CSF2RA/TNF/BMP5/LTB/LTBR/TNFRSF21/IL2RG/BMP4/IL1RN/IL4R/IL17RA/IL32/EDA/IL1R1	-0.293594314792087
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/960	116/9376	0.926149425287356	TKT/PKM/ADPGK/ACSS1/IDH3B/GPI/OGDH/PDHB/PGD/H6PD/HK1	-0.270299829635642
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/960	43/9376	0.908527131782946	CD36/PLA2G2A/PLPP3/SLC27A1	-0.203041252222893
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/960	54/9376	0.904320987654321	HLA-DRB5/HLA-DMB/CGA/GZMB/PRF1	-0.238137289179512
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/960	10/9376	0.976666666666667	SELENBP1	-0.0249326304440432
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/960	33/9376	0.887878787878788	VAMP2/STX16/VAMP5	-0.217906392563645
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/960	97/9376	0.906185567010309	PER3/GNG2/PRKCB/PER1/PLCB2/CREB1/RYR1/CAMK2G/PRKG1	-0.313670249331613
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/960	76/9376	0.899561403508772	CD36/OLR1/PLTP/ACAA1/PLIN2/RXRA/SLC27A1	-0.296916510935118
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/960	76/9376	0.899561403508772	ITPR2/EZR/PRKCB/PLCB2/ATP1A1/MYLK/CAMK2G	-0.296916510935118
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/960	323/9376	0.937358101135191	ZEB2/VIM/ATM/TPM1/ROCK1/MDM4/TIMP3/PIK3R1/APC/DICER1/EZR/CCND2/EP300/TNXB/MCL1/FOXP1/CDK6/CD44/DNMT1/PRKCB/PDGFRA/IKBKB/EGFR/NOTCH2/THBS1/CDKN1A/DNMT3A/SOX4/SOS1/RAF1/PIK3R3	-0.386935259217561
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/960	45/9376	0.868148148148148	ABCA6/ABCD4/ABCA9/ABCC5	-0.299431018334653
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/960	99/9376	0.887878787878788	ITPR2/PIK3R1/HRH1/PRKCB/PLCB2/PIK3R3/MAPK14/CAMK2G/IL1R1	-0.378765133919297
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/960	23/9376	0.84927536231884	LNPEP/ANPEP	-0.244422448717208
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/960	78/9376	0.876495726495726	FN1/WASF2/PIK3R1/CBL/DNM1/VCL/PIK3R3	-0.369915821806751
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/960	78/9376	0.876495726495726	JUN/C4BPB/TNF/IRF3/C1R/MAPK14/C1S	-0.369915821806751
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/960	35/9376	0.837142857142857	ENOSF1/PFKFB2/HK1	-0.325996200797373
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/960	36/9376	0.813888888888889	ST3GAL1/GALNT6/GALNT7	-0.377849198669542
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/960	59/9376	0.827683615819209	GSTP1/GPX3/ANPEP/GCLC/PGD	-0.448417881298753
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/960	37/9376	0.791891891891892	GPI/NANS/HK1	-0.428359168379975
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/960	104/9376	0.845192307692308	PLA2G2A/DGKZ/GPCPD1/DGKH/LPGAT1/LPIN2/PCYT1A/PLPP3/LPIN1	-0.536155649113876
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/960	26/9376	0.751282051282051	PLA2G2A/ACAA1	-0.428900336630819
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/960	38/9376	0.771052631578947	AMDHD2/GPI/HK1	-0.477605050693105
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/960	38/9376	0.771052631578947	PTPRC/CIITA/IL2RG	-0.477605050693105
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/960	27/9376	0.723456790123457	HADHA/ACSM5	-0.48599375984293
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/960	14/9376	0.697619047619048	ST3GAL1	-0.382386473613669
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/960	85/9376	0.804313725490196	ENPP1/GUK1/APRT/NT5C/ADA2/IMPDH1/NME6	-0.612078309280432
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/960	63/9376	0.775132275132275	PTGDS/PLA2G2A/LTA4H/PTGES/HPGD	-0.60481282315633
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/960	63/9376	0.775132275132275	UVSSA/XPA/DDB1/POLR2I/CCNH	-0.60481282315633
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/960	15/9376	0.651111111111111	ST3GAL1	-0.456709490964847
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/960	110/9376	0.799090909090909	PIK3R1/CPEB4/ANAPC5/IGF1R/RAF1/PIK3R3/ANAPC7/MAPK14/KIF22	-0.715843646126779
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/960	16/9376	0.610416666666667	ALDH3B1	-0.526733363283306
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/960	16/9376	0.610416666666667	ST3GAL1	-0.526733363283306
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/960	30/9376	0.651111111111111	PIGM/DPM2	-0.646402859499959
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/960	157/9376	0.808704883227176	APC/CCND2/CSNK1D/WNT2/BMP5/AREG/BIRC3/BMP4/SMAD2/DLG1/PPP2R2A/TCF7L2/GSK3B	-0.816357136925516
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/960	43/9376	0.681395348837209	HADHA/ACAA1/ALDH2	-0.707203005623805
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/960	17/9376	0.574509803921569	CA8	-0.593017740997443
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/960	44/9376	0.665909090909091	MAN1A2/MAN1B1/TUSC3	-0.750191299043872
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/960	32/9376	0.610416666666667	GALM/HK1	-0.745550961704376
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/960	32/9376	0.610416666666667	BIRC6/BIRC3	-0.745550961704376
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/960	18/9376	0.542592592592593	ACSF3	-0.656018847481508
NA	NA	hsa04081	Hormone signaling	18/960	219/9376	0.802739726027397	CSH1/PRLR/PIK3R1/CGA/CSH2/SLC40A1/GNG2/JAK2/ADRB2/PLCB2/IGF1R/SMAD5/ITGAV/VIPR2/THRA/PIK3R3/PRKG1/INSR	-0.99759318498448
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/960	34/9376	0.574509803921569	POLR2I/POLR1A	-0.839416450590855
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/960	20/9376	0.488333333333333	LBR	-0.773615936556665
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/960	20/9376	0.488333333333333	NANS	-0.773615936556665
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/960	168/9376	0.755753968253968	CFLAR/SLC25A6/JAK1/JAK2/TNF/CYLD/BIRC3/STAT6/TRPM7/DNM1L/SLC25A4/TRAF5/CAMK2G	-1.07886696049472
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/960	49/9376	0.597959183673469	OGT/GALNT6/GALNT7	-0.952940070396768
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/960	36/9376	0.542592592592593	RNASEH2B/RNASEH2C	-0.928644299217679
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/960	51/9376	0.574509803921569	PLA2G2A/ENPP2/PLPP3	-1.0290076817584
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/960	102/9376	0.670261437908497	ATP2B1/ITPR2/PLA2G2A/ATP2B4/PRKCB/PLCB2/ATP1A1	-1.13084913760443
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/960	23/9376	0.42463768115942	LARGE1	-0.93303569366088
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/960	23/9376	0.42463768115942	PCYOX1	-0.93303569366088
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/960	23/9376	0.42463768115942	MLH3	-0.93303569366088
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/960	23/9376	0.42463768115942	ATP1A1	-0.93303569366088
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/960	54/9376	0.542592592592593	REV3L/POLK/CENPX	-1.13844987923883
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/960	69/9376	0.566183574879227	ITPR2/ADRB2/PLCB2/CREB1	-1.22150168651938
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/960	56/9376	0.523214285714286	CR1/CLK1/TNF	-1.2085863446073
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/960	83/9376	0.588353413654618	CCL5/MAVS/IRF3/IKBKB/GSDMD	-1.27219588715238
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/960	59/9376	0.496610169491525	ENPP1/NT5C/NME6	-1.30996830241701
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/960	138/9376	0.63695652173913	ITPR2/SMC1A/CPEB4/ANAPC5/SLK/IGF1R/ANAPC7/MAPK14/CAMK2G	-1.45103402094588
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/960	75/9376	0.520888888888889	TKT/PKM/IDH3B/MTR	-1.40692336975679
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/960	46/9376	0.42463768115942	UROS/UROD	-1.32113713886123
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/960	46/9376	0.42463768115942	PSMD7/PSMD13	-1.32113713886123
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/960	89/9376	0.548689138576779	GNG2/PRKCB/GABARAPL1/SLC38A2/SLC38A1	-1.44477912277559
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/960	116/9376	0.589367816091954	ITPR2/GNG2/PRKCB/PLCB2/SLC38A2/HOMER1/SLC38A1	-1.50295119279896
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/960	154/9376	0.634199134199134	QPRT/GCLC/COQ7/UROS/COQ4/NME6/ALDH2/NAPRT/UROD/COASY	-1.54582711841702
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/960	30/9376	0.325555555555556	PLA2G2A	-1.24957495451107
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/960	31/9376	0.31505376344086	ALDH2	-1.29007829700461
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/960	31/9376	0.31505376344086	ACSS1	-1.29007829700461
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/960	50/9376	0.390666666666667	AOC1/ALDH2	-1.45901791519235
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/960	82/9376	0.476422764227642	GSTP1/CES2/IMPDH1/NME6	-1.60825436704811
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/960	36/9376	0.271296296296296	DCXR	-1.47943939976582
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/960	128/9376	0.534114583333333	ENPP1/GUK1/APRT/NT5C/ADA2/IMPDH1/NME6	-1.79237377856695
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/960	37/9376	0.263963963963964	RIMKLB	-1.51501922323134
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/960	37/9376	0.263963963963964	ALDH3B1	-1.51501922323134
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/960	115/9376	0.509565217391304	ITPR2/GNG2/PRKCB/PLCB2/RAF1/APP	-1.78718550330387
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/960	143/9376	0.546386946386946	HLA-DRB5/C7/HLA-DMB/ACTN4/TNF/C1R/ACTN1/C1S	-1.84608007964477
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/960	90/9376	0.434074074074074	EPHX1/ATP1A1/RXRA/SLC2A1	-1.82194346409505
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/960	41/9376	0.238211382113821	ATM	-1.65096413152262
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/960	191/9376	0.562478184991274	FOSB/ATF4/CREB3L2/GNG2/CREB1/CREB3L1/HDAC7/ATF6B/CAMKK2/SOS1/RAF1	-2.06321842079546
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/960	79/9376	0.370886075949367	GSTP1/EPHX1/ALDH3B1	-1.8964431089936
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/960	83/9376	0.353012048192771	ABCD4/FAR1/ACAA1	-1.9995195845878
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/960	66/9376	0.295959595959596	HSD17B2/HSD17B1	-1.93848793392611
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/960	70/9376	0.279047619047619	GSTP1/EPHX1	-2.04476059722409
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/960	73/9376	0.267579908675799	GSTP1/ALDH3B1	-2.12167353902361
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/960	55/9376	0.177575757575758	PLPP3	-2.06592421222535
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/960	183/9376	0.42695810564663	FBL/WDR43/NHP2/MPHOSPH10/UTP14C/LSG1/MDN1/NOP58	-2.64394051536368
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/960	86/9376	0.227131782945736	SCN9A/PLCB2	-2.43172918971488
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/960	68/9376	0.143627450980392	ALDH1A1	-2.3936320865098
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/960	91/9376	0.214652014652015	GNG2/PRKCB	-2.54249593606523
NA	NA	hsa04082	Neuroactive ligand signaling	6/960	199/9376	0.294472361809045	HRH1/GNG2/PRKCB/ADRB2/PLCB2/P2RY13	-3.39749319120719
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/960	370/9376	0.395945945945946	CSH1/PRLR/TSPO/CGA/CSH2/HRH1/ADRB2/P2RX7/C5AR1/SPX/P2RY13/VIPR2/THRA/KISS1/GZMA	-4.00386186243
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/960	449/9376	0.0652561247216036	SLC8A1/CAMK2G/PRKG1	-6.85537825580357