ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 50/1817 168/18639 0.297619047619048 3.05301124302225 2.59056869019169e-13 3.14235982120252e-10 GO:0003712 transcription coregulator activity 100/1817 495/18639 0.202020202020202 2.07234702556662 9.79571419478982e-13 5.94110065914003e-10 GO:0003735 structural constituent of ribosome 47/1817 175/18639 0.268571428571429 2.75503734570328 7.20300739856175e-11 2.91241599148513e-08 GO:0019838 growth factor binding 37/1817 136/18639 0.272058823529412 2.79081145391563 5.04305138809463e-09 1.30513076839617e-06 GO:0003713 transcription coactivator activity 56/1817 256/18639 0.21875 2.24396326362135 5.37976409066845e-09 1.30513076839617e-06 GO:0045296 cadherin binding 66/1817 334/18639 0.197604790419162 2.02705321333118 1.82744731746865e-08 3.57074236755391e-06 GO:0005178 integrin binding 40/1817 161/18639 0.248447204968944 2.54860068982727 2.06060977517538e-08 3.57074236755391e-06 GO:0042393 histone binding 52/1817 247/18639 0.210526315789474 2.15960374243258 7.09270711740794e-08 1.07543171667698e-05 GO:0140297 DNA-binding transcription factor binding 82/1817 488/18639 0.168032786885246 1.72370011819158 6.3373882331381e-07 6.92865744739651e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 30/1817 118/18639 0.254237288135593 2.6079960448868 6.88547629718211e-07 6.92865744739651e-05 GO:0003779 actin binding 76/1817 443/18639 0.171557562076749 1.7598576772419 7.15127376242256e-07 6.92865744739651e-05 GO:0005518 collagen binding 22/1817 72/18639 0.305555555555556 3.13442487616951 7.37349561284057e-07 6.92865744739651e-05 GO:0016922 nuclear receptor binding 33/1817 137/18639 0.240875912408759 2.47093347902414 7.42560155120813e-07 6.92865744739651e-05 GO:0050840 extracellular matrix binding 21/1817 67/18639 0.313432835820896 3.2152309448903 8.20070816428837e-07 7.10532785948699e-05 GO:0097493 structural molecule activity conferring elasticity 8/1817 11/18639 0.727272727272727 7.46044929203983 1.01258907892303e-06 8.1745958815525e-05 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 21/1817 68/18639 0.308823529411765 3.16794813687721 1.07826491430206e-06 8.1745958815525e-05 GO:0008201 heparin binding 38/1817 172/18639 0.22093023255814 2.26632834598303 1.14614024658921e-06 8.17804775948655e-05 GO:0005539 glycosaminoglycan binding 48/1817 242/18639 0.198347107438017 2.03466798873813 1.38684111838841e-06 9.34576820336188e-05 GO:0031267 small GTPase binding 53/1817 283/18639 0.187279151943463 1.92113159772934 2.49577136250463e-06 0.000159335298037795 GO:0030695 GTPase regulator activity 79/1817 489/18639 0.161554192229039 1.65724193118165 4.74867583337555e-06 0.000274839077792906 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 61/1817 349/18639 0.174785100286533 1.79296614432619 4.75813737316656e-06 0.000274839077792906 GO:0060589 nucleoside-triphosphatase regulator activity 79/1817 490/18639 0.161224489795918 1.65385980479148 5.13355499323683e-06 0.000283045554854376 GO:0051020 GTPase binding 56/1817 315/18639 0.177777777777778 1.82366538249862 6.84663064456929e-06 0.00036108534660272 GO:0015078 proton transmembrane transporter activity 38/1817 185/18639 0.205405405405405 2.10707284058963 7.22898624695195e-06 0.000365365013231363 GO:0004713 protein tyrosine kinase activity 31/1817 140/18639 0.221428571428571 2.27144036480855 1.02489838732125e-05 0.000489360768451747 GO:0051015 actin filament binding 41/1817 209/18639 0.196172248803828 2.01235803272127 1.04891838250168e-05 0.000489360768451747 GO:1901681 sulfur compound binding 50/1817 275/18639 0.181818181818182 1.86511232300996 1.1127591080051e-05 0.000499917332596367 GO:0001221 transcription coregulator binding 27/1817 115/18639 0.234782608695652 2.40842765188677 1.21644124386695e-05 0.000526979724575217 GO:0004386 helicase activity 33/1817 155/18639 0.212903225806452 2.18398636533101 1.29565833225971e-05 0.000541942605872769 GO:0043021 ribonucleoprotein complex binding 36/1817 177/18639 0.203389830508475 2.08639683590944 1.56270095772343e-05 0.000631852087239508 GO:0008137 NADH dehydrogenase (ubiquinone) activity 14/1817 41/18639 0.341463414634146 3.50277192370163 1.85617885919141e-05 0.000702101613190042 GO:0048407 platelet-derived growth factor binding 7/1817 11/18639 0.636363636363636 6.52789313053485 1.91661463145394e-05 0.000702101613190042 GO:0005516 calmodulin binding 40/1817 207/18639 0.193236714975845 1.98224498097677 1.93243231575967e-05 0.000702101613190042 GO:0140658 ATP-dependent chromatin remodeler activity 33/1817 158/18639 0.208860759493671 2.14251826978675 1.96796824801825e-05 0.000702101613190042 GO:0015399 primary active transmembrane transporter activity 34/1817 166/18639 0.204819277108434 2.10106026748712 2.28246168744949e-05 0.000791036007678924 GO:0140938 histone H3 methyltransferase activity 15/1817 47/18639 0.319148936170213 3.2738673754962 2.36621662326006e-05 0.000797283545559571 GO:0061775 cohesin loader activity 32/1817 153/18639 0.209150326797386 2.1454886852925 2.53715693598875e-05 0.000821592901092625 GO:0140597 protein carrier chaperone 37/1817 188/18639 0.196808510638298 2.01888488155599 2.5738277198285e-05 0.000821592901092625 GO:0008094 ATP-dependent activity, acting on DNA 40/1817 210/18639 0.19047619047619 1.95392719553424 2.73206928643744e-05 0.000849743601140671 GO:0048156 tau protein binding 14/1817 43/18639 0.325581395348837 3.33985229934341 3.4248021974491e-05 0.00103857126637644 GO:0140996 histone H3 kinase activity 59/1817 357/18639 0.165266106442577 1.69531918436059 3.77235448493777e-05 0.00111606487566574 GO:0140033 acetylation-dependent protein binding 10/1817 24/18639 0.416666666666667 4.27421574023115 4.11072233999406e-05 0.00116611331838455 GO:0009055 electron transfer activity 26/1817 116/18639 0.224137931034483 2.29923329474503 4.13378999921977e-05 0.00116611331838455 GO:0140713 histone chaperone activity 33/1817 164/18639 0.201219512195122 2.06413345503846 4.34577834071821e-05 0.00119040697908359 GO:0003954 NADH dehydrogenase activity 14/1817 44/18639 0.318181818181818 3.26394656526742 4.57540911618217e-05 0.00119040697908359 GO:0035173 histone kinase activity 59/1817 360/18639 0.163888888888889 1.68119152449092 4.82426884929017e-05 0.00119040697908359 GO:0000510 H3-H4 histone complex chaperone activity 31/1817 151/18639 0.205298013245033 2.10597119916025 4.90687130702223e-05 0.00119040697908359 GO:0140584 chromatin extrusion motor activity 31/1817 151/18639 0.205298013245033 2.10597119916025 4.90687130702223e-05 0.00119040697908359 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 31/1817 151/18639 0.205298013245033 2.10597119916025 4.90687130702223e-05 0.00119040697908359 GO:0140849 ATP-dependent H2AZ histone chaperone activity 31/1817 151/18639 0.205298013245033 2.10597119916025 4.90687130702223e-05 0.00119040697908359 GO:0046332 SMAD binding 20/1817 79/18639 0.253164556962025 2.59699184216576 5.09530818413703e-05 0.00121188408379573 GO:0015616 DNA translocase activity 31/1817 152/18639 0.203947368421053 2.09211612548156 5.59784423537524e-05 0.00126133038980245 GO:0140674 ATP-dependent histone chaperone activity 31/1817 152/18639 0.203947368421053 2.09211612548156 5.59784423537524e-05 0.00126133038980245 GO:0141003 histone H2AX kinase activity 58/1817 354/18639 0.163841807909605 1.68070856226038 5.61515589854349e-05 0.00126133038980245 GO:0050681 nuclear androgen receptor binding 10/1817 26/18639 0.384615384615385 3.94542991405952 9.27801050620436e-05 0.00204622304436834 GO:0035198 miRNA binding 13/1817 42/18639 0.30952380952381 3.17513169274314 0.000116997027778493 0.00253423919098772 GO:0019207 kinase regulator activity 48/1817 287/18639 0.167247386759582 1.7156433912008 0.000143443913940431 0.00305258715104812 GO:0003689 DNA clamp loader activity 31/1817 160/18639 0.19375 1.98751031920748 0.000151617985723628 0.00317090718418553 GO:0003714 transcription corepressor activity 37/1817 204/18639 0.181372549019608 1.86054096927709 0.000154529510917922 0.00317702197870236 GO:0140097 catalytic activity, acting on DNA 54/1817 336/18639 0.160714285714286 1.64862607123202 0.000165894427332023 0.0033164445546771 GO:0004674 protein serine/threonine kinase activity 66/1817 433/18639 0.152424942263279 1.56359300982128 0.000166779157325064 0.0033164445546771 GO:0016887 ATP hydrolysis activity 64/1817 417/18639 0.15347721822542 1.57438738057435 0.000170791497720745 0.00334145301185909 GO:0042054 histone methyltransferase activity 17/1817 67/18639 0.253731343283582 2.60280600300643 0.000177178235388878 0.00339322115454964 GO:0070577 lysine-acetylated histone binding 9/1817 23/18639 0.391304347826087 4.01404608647795 0.000179032278558267 0.00339322115454964 GO:0046966 nuclear thyroid hormone receptor binding 10/1817 28/18639 0.357142857142857 3.6636134916267 0.000191094210839336 0.00356611196535562 GO:0019887 protein kinase regulator activity 43/1817 255/18639 0.168627450980392 1.72980025251708 0.00025842837602229 0.00473952252291652 GO:0048027 mRNA 5'-UTR binding 9/1817 24/18639 0.375 3.84679416620804 0.000261787311653262 0.00473952252291652 GO:0005096 GTPase activator activity 45/1817 271/18639 0.166051660516605 1.70337749057182 0.00026849481945076 0.00478947376461429 GO:0019955 cytokine binding 28/1817 144/18639 0.194444444444444 1.99463401210787 0.000290727491478308 0.00511090503135054 GO:0140104 molecular carrier activity 42/1817 249/18639 0.168674698795181 1.73028492616586 0.000300998026711428 0.00521586580572804 GO:0097110 scaffold protein binding 17/1817 70/18639 0.242857142857143 2.49125717430616 0.000312360295513921 0.00533652166842797 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 15/1817 58/18639 0.258620689655172 2.65296149393658 0.000334873383064021 0.00556440292680353 GO:0061980 regulatory RNA binding 15/1817 58/18639 0.258620689655172 2.65296149393658 0.000334873383064021 0.00556440292680353 GO:0004709 MAP kinase kinase kinase activity 9/1817 25/18639 0.36 3.69292239955971 0.000373863366546701 0.00604661684828197 GO:0042974 nuclear retinoic acid receptor binding 9/1817 25/18639 0.36 3.69292239955971 0.000373863366546701 0.00604661684828197 GO:0051018 protein kinase A binding 14/1817 53/18639 0.264150943396226 2.70969148814654 0.000414128888234975 0.00660971501880296 GO:0031625 ubiquitin protein ligase binding 48/1817 302/18639 0.158940397350993 1.6304293154789 0.000480295875444761 0.00756621944044798 GO:0043394 proteoglycan binding 11/1817 37/18639 0.297297297297297 3.04971069032709 0.000571689134039306 0.00889049896909844 GO:0002020 protease binding 26/1817 136/18639 0.191176470588235 1.96111075140017 0.000615876815106186 0.00945643768004814 GO:0001222 transcription corepressor binding 13/1817 49/18639 0.26530612244898 2.72154145092269 0.000630261259383885 0.00955633634540815 GO:0035401 histone H3Y41 kinase activity 23/1817 115/18639 0.2 2.05162355531095 0.000646974118608394 0.0095704829984388 GO:0140801 histone H2AXY142 kinase activity 23/1817 115/18639 0.2 2.05162355531095 0.000646974118608394 0.0095704829984388 GO:0001618 virus receptor activity 18/1817 81/18639 0.222222222222222 2.27958172812328 0.000669929771219233 0.00979066039143288 GO:0050321 tau-protein kinase activity 8/1817 22/18639 0.363636363636364 3.73022464601991 0.000734431981527634 0.0106055475427741 GO:0030020 extracellular matrix structural constituent conferring tensile strength 12/1817 44/18639 0.272727272727273 2.79766848451493 0.000772250396900519 0.0109301315815905 GO:0140272 exogenous protein binding 18/1817 82/18639 0.219512195121951 2.25178195095104 0.000781442209844207 0.0109301315815905 GO:0031994 insulin-like growth factor I binding 6/1817 13/18639 0.461538461538462 4.73451589687143 0.000798011892847171 0.0109301315815905 GO:0002039 p53 binding 16/1817 69/18639 0.231884057971014 2.37869397717212 0.000801963487849591 0.0109301315815905 GO:0016279 protein-lysine N-methyltransferase activity 16/1817 69/18639 0.231884057971014 2.37869397717212 0.000801963487849591 0.0109301315815905 GO:0016278 lysine N-methyltransferase activity 16/1817 70/18639 0.228571428571429 2.34471263464109 0.000947031100393497 0.0127638747197479 GO:0004715 non-membrane spanning protein tyrosine kinase activity 12/1817 45/18639 0.266666666666667 2.73549807374794 0.000960875028758937 0.0128081473613691 GO:0106310 protein serine kinase activity 54/1817 361/18639 0.149584487534626 1.53445529067578 0.000978159116941139 0.0128968153135826 GO:0004706 JUN kinase kinase kinase activity 7/1817 18/18639 0.388888888888889 3.98926802421574 0.000999300175984655 0.013033882940531 GO:0019209 kinase activator activity 27/1817 148/18639 0.182432432432432 1.87141337815526 0.00103281476963615 0.0133277054847729 GO:0043022 ribosome binding 22/1817 112/18639 0.196428571428571 2.01498742039468 0.00107774936722914 0.0137611577099889 GO:0043236 laminin binding 9/1817 29/18639 0.310344827586207 3.18355379272389 0.0012804503341826 0.0160286392849706 GO:0044548 S100 protein binding 6/1817 14/18639 0.428571428571429 4.39633618995204 0.00128176258090861 0.0160286392849706 GO:0008017 microtubule binding 43/1817 276/18639 0.155797101449275 1.59818501591252 0.00137825344959425 0.016956227685439 GO:0140296 general transcription initiation factor binding 13/1817 53/18639 0.245283018867925 2.51614209613607 0.00139727602499616 0.016956227685439 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/1817 24/18639 0.333333333333333 3.41937259218492 0.00141507407884032 0.016956227685439 GO:0005381 iron ion transmembrane transporter activity 5/1817 10/18639 0.5 5.12905888827738 0.00144998266732755 0.016956227685439 GO:0042975 peroxisome proliferator activated receptor binding 5/1817 10/18639 0.5 5.12905888827738 0.00144998266732755 0.016956227685439 GO:0061749 forked DNA-dependent helicase activity 12/1817 47/18639 0.25531914893617 2.61909390039696 0.00145379033741604 0.016956227685439 GO:1990518 single-stranded 3'-5' DNA helicase activity 12/1817 47/18639 0.25531914893617 2.61909390039696 0.00145379033741604 0.016956227685439 GO:0001098 basal transcription machinery binding 14/1817 60/18639 0.233333333333333 2.39356081452944 0.00156333792851046 0.0178898953517282 GO:0001099 basal RNA polymerase II transcription machinery binding 14/1817 60/18639 0.233333333333333 2.39356081452944 0.00156333792851046 0.0178898953517282 GO:0048306 calcium-dependent protein binding 17/1817 80/18639 0.2125 2.17985002751789 0.00157832937001312 0.017892649774074 GO:0005085 guanyl-nucleotide exchange factor activity 37/1817 230/18639 0.160869565217391 1.65021894666316 0.00161826059202668 0.0181754638715589 GO:0001968 fibronectin binding 9/1817 30/18639 0.3 3.07743533296643 0.00167284203293246 0.0186161228068539 GO:0009378 four-way junction helicase activity 12/1817 48/18639 0.25 2.56452944413869 0.00176912057632396 0.0189980074743336 GO:0036121 double-stranded DNA helicase activity 12/1817 48/18639 0.25 2.56452944413869 0.00176912057632396 0.0189980074743336 GO:0043138 3'-5' DNA helicase activity 12/1817 48/18639 0.25 2.56452944413869 0.00176912057632396 0.0189980074743336 GO:0031491 nucleosome binding 16/1817 74/18639 0.216216216216216 2.21797141114698 0.00176980613734518 0.0189980074743336 GO:0008276 protein methyltransferase activity 19/1817 95/18639 0.2 2.05162355531095 0.00183872531888617 0.0195646825597274 GO:0030295 protein kinase activator activity 25/1817 139/18639 0.179856115107914 1.84498521161057 0.00190647437731981 0.020109160171208 GO:0044389 ubiquitin-like protein ligase binding 48/1817 322/18639 0.149068322981366 1.52916041389636 0.00194639377264842 0.0201593844762826 GO:0005523 tropomyosin binding 6/1817 15/18639 0.4 4.1032471106219 0.00196109428540919 0.0201593844762826 GO:0051371 muscle alpha-actinin binding 6/1817 15/18639 0.4 4.1032471106219 0.00196109428540919 0.0201593844762826 GO:0003725 double-stranded RNA binding 16/1817 75/18639 0.213333333333333 2.18839845899835 0.00205005700894275 0.0208967995953576 GO:0070325 lipoprotein particle receptor binding 9/1817 31/18639 0.290322580645161 2.97816322545138 0.00215593473959174 0.0217929069927065 GO:0008172 S-methyltransferase activity 5/1817 11/18639 0.454545454545455 4.66278080752489 0.00244564785402483 0.0245171144374555 GO:0050750 low-density lipoprotein particle receptor binding 8/1817 26/18639 0.307692307692308 3.15634393124762 0.00251944822982759 0.0249291896149566 GO:0015631 tubulin binding 55/1817 385/18639 0.142857142857143 1.46544539665068 0.00252785681998323 0.0249291896149566 GO:0140030 modification-dependent protein binding 29/1817 173/18639 0.167630057803468 1.71956887583866 0.00264697855717595 0.0258934273375357 GO:0008170 N-methyltransferase activity 19/1817 98/18639 0.193877551020408 1.98881875259735 0.00266971035993687 0.0259068693328273 GO:0042162 telomeric DNA binding 10/1817 38/18639 0.263157894736842 2.69950467804073 0.00278818058963244 0.0268417702795568 GO:0016675 oxidoreductase activity, acting on a heme group of donors 6/1817 16/18639 0.375 3.84679416620804 0.00288100439718177 0.0275169947541849 GO:0019843 rRNA binding 14/1817 65/18639 0.215384615384615 2.20944075187333 0.00346787479421155 0.0322997357019906 GO:0005080 protein kinase C binding 12/1817 52/18639 0.230769230769231 2.36725794843571 0.00363936329033501 0.0322997357019906 GO:0032931 histone H3K56 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0043992 histone H3K9 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0043993 histone H3K18 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0043994 histone H3K23 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0043999 histone H2AK5 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0044012 histone H2AK9 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0044014 histone H2BK5 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0044015 histone H2BK12 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0044016 histone H3K4 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0044017 histone H3K27 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0044018 histone H3K36 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0046972 histone H4K16 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:0140908 histone H3K122 acetyltransferase activity 7/1817 22/18639 0.318181818181818 3.26394656526742 0.00378117268728991 0.0322997357019906 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/1817 12/18639 0.416666666666667 4.27421574023115 0.00385806973486869 0.0327261439747952 GO:0030169 low-density lipoprotein particle binding 6/1817 17/18639 0.352941176470588 3.62051215643109 0.00408893623506518 0.0344436087023199 GO:0051959 dynein light intermediate chain binding 8/1817 28/18639 0.285714285714286 2.93089079330136 0.00420358561159698 0.0351651679094285 GO:0030332 cyclin binding 9/1817 34/18639 0.264705882352941 2.71538411732332 0.00429477805497547 0.0356819574019537 GO:0003678 DNA helicase activity 15/1817 74/18639 0.202702702702703 2.07934819795029 0.00465707441215593 0.0384287840948649 GO:0017134 fibroblast growth factor binding 7/1817 23/18639 0.304347826086957 3.12203584503841 0.00498452848203473 0.0405787452933431 GO:0044013 histone H2B acetyltransferase activity 7/1817 23/18639 0.304347826086957 3.12203584503841 0.00498452848203473 0.0405787452933431 GO:0140463 chromatin-protein adaptor activity 12/1817 54/18639 0.222222222222222 2.27958172812328 0.00504325125049543 0.0407830917790064 GO:0005154 epidermal growth factor receptor binding 9/1817 35/18639 0.257142857142857 2.63780171397122 0.00529042608909896 0.0423825279942967 GO:0004857 enzyme inhibitor activity 57/1817 416/18639 0.137019230769231 1.40555940688371 0.00531091859450379 0.0423825279942967 GO:0017154 semaphorin receptor activity 5/1817 13/18639 0.384615384615385 3.94542991405952 0.00577060588613212 0.0448701598710145 GO:0043560 insulin receptor substrate binding 5/1817 13/18639 0.384615384615385 3.94542991405952 0.00577060588613212 0.0448701598710145 GO:0046974 histone H3K9 methyltransferase activity 5/1817 13/18639 0.384615384615385 3.94542991405952 0.00577060588613212 0.0448701598710145 GO:0046975 histone H3K36 methyltransferase activity 5/1817 13/18639 0.384615384615385 3.94542991405952 0.00577060588613212 0.0448701598710145 GO:0008135 translation factor activity, RNA binding 16/1817 83/18639 0.192771084337349 1.9774684870467 0.00590674151491422 0.0456361621502608 GO:0008307 structural constituent of muscle 10/1817 42/18639 0.238095238095238 2.4424089944178 0.00606347526139091 0.046550604380172 GO:0044325 transmembrane transporter binding 23/1817 136/18639 0.169117647058824 1.73482874162323 0.00619818178321568 0.0472855000191234 GO:0043998 histone H2A acetyltransferase activity 7/1817 24/18639 0.291666666666667 2.99195101816181 0.00645430382452654 0.0486277673239174 GO:0050431 transforming growth factor beta binding 7/1817 24/18639 0.291666666666667 2.99195101816181 0.00645430382452654 0.0486277673239174 GO:0180051 translation factor activity 16/1817 84/18639 0.19047619047619 1.95392719553424 0.00665267146436679 0.0498129042362772 GO:0003724 RNA helicase activity 15/1817 77/18639 0.194805194805195 1.99833463179638 0.00683321607346448 0.0508508656264565 GO:0005520 insulin-like growth factor binding 6/1817 19/18639 0.315789473684211 3.23940561364887 0.00756470500829966 0.0556120434852575 GO:0042800 histone H3K4 methyltransferase activity 6/1817 19/18639 0.315789473684211 3.23940561364887 0.00756470500829966 0.0556120434852575 GO:0042805 actinin binding 9/1817 37/18639 0.243243243243243 2.49521783754035 0.00780819392555693 0.0570562604319311 GO:0008186 ATP-dependent activity, acting on RNA 15/1817 79/18639 0.189873417721519 1.94774388162432 0.00868952556658171 0.0631161348039738 GO:0017116 single-stranded DNA helicase activity 12/1817 58/18639 0.206896551724138 2.12236919514926 0.00912537253127477 0.0658873623835494 GO:0000146 microfilament motor activity 9/1817 38/18639 0.236842105263158 2.42955421023665 0.00936612909877486 0.066010839747034 GO:0043531 ADP binding 9/1817 38/18639 0.236842105263158 2.42955421023665 0.00936612909877486 0.066010839747034 GO:0033218 amide binding 36/1817 247/18639 0.145748987854251 1.49511028322256 0.00941457153852999 0.066010839747034 GO:0035402 histone H3T11 kinase activity 36/1817 247/18639 0.145748987854251 1.49511028322256 0.00941457153852999 0.066010839747034 GO:0035403 histone H3T6 kinase activity 36/1817 247/18639 0.145748987854251 1.49511028322256 0.00941457153852999 0.066010839747034 GO:0004679 AMP-activated protein kinase activity 36/1817 248/18639 0.145161290322581 1.48908161272569 0.0100102070042797 0.0693213521798442 GO:0070717 poly-purine tract binding 8/1817 32/18639 0.25 2.56452944413869 0.0100225568206066 0.0693213521798442 GO:0046915 transition metal ion transmembrane transporter activity 10/1817 45/18639 0.222222222222222 2.27958172812328 0.0100581681645941 0.0693213521798442 GO:0008143 poly(A) binding 7/1817 26/18639 0.269230769230769 2.76180093984167 0.0103249324313203 0.0703603541527613 GO:0052742 phosphatidylinositol kinase activity 7/1817 26/18639 0.269230769230769 2.76180093984167 0.0103249324313203 0.0703603541527613 GO:0016651 oxidoreductase activity, acting on NAD(P)H 16/1817 88/18639 0.181818181818182 1.86511232300996 0.0104275825497825 0.0705246373359397 GO:0070063 RNA polymerase binding 12/1817 59/18639 0.203389830508475 2.08639683590944 0.0104653212864544 0.0705246373359397 GO:0004129 cytochrome-c oxidase activity 5/1817 15/18639 0.333333333333333 3.41937259218492 0.0114160644408465 0.074571893796334 GO:0005041 low-density lipoprotein particle receptor activity 5/1817 15/18639 0.333333333333333 3.41937259218492 0.0114160644408465 0.074571893796334 GO:0042809 nuclear vitamin D receptor binding 5/1817 15/18639 0.333333333333333 3.41937259218492 0.0114160644408465 0.074571893796334 GO:0055105 ubiquitin-protein transferase inhibitor activity 5/1817 15/18639 0.333333333333333 3.41937259218492 0.0114160644408465 0.074571893796334 GO:0001094 TFIID-class transcription factor complex binding 4/1817 10/18639 0.4 4.1032471106219 0.011680675862575 0.074571893796334 GO:0003680 minor groove of adenine-thymine-rich DNA binding 4/1817 10/18639 0.4 4.1032471106219 0.011680675862575 0.074571893796334 GO:0005031 tumor necrosis factor receptor activity 4/1817 10/18639 0.4 4.1032471106219 0.011680675862575 0.074571893796334 GO:0005131 growth hormone receptor binding 4/1817 10/18639 0.4 4.1032471106219 0.011680675862575 0.074571893796334 GO:0016303 1-phosphatidylinositol-3-kinase activity 4/1817 10/18639 0.4 4.1032471106219 0.011680675862575 0.074571893796334 GO:0045322 unmethylated CpG binding 4/1817 10/18639 0.4 4.1032471106219 0.011680675862575 0.074571893796334 GO:0031490 chromatin DNA binding 21/1817 128/18639 0.1640625 1.68297244771602 0.0121056511315045 0.0768803917409163 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 35/1817 243/18639 0.1440329218107 1.47750667563546 0.0123116653538664 0.0777815108033328 GO:0004177 aminopeptidase activity 9/1817 40/18639 0.225 2.30807649972482 0.0131711694420781 0.079677200503121 GO:0001784 phosphotyrosine residue binding 10/1817 47/18639 0.212765957446809 2.1825782503308 0.013665057453428 0.079677200503121 GO:0004676 3-phosphoinositide-dependent protein kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0004711 ribosomal protein S6 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0035175 histone H3S10 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0035979 histone H2AXS139 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0044022 histone H3S28 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0044023 histone H4S1 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0044024 histone H2AS1 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0044025 histone H2BS14 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0072354 histone H3T3 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0072371 histone H2AS121 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0072518 Rho-dependent protein serine/threonine kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0140823 histone H2BS36 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0140855 histone H3S57 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0140995 histone H2A kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0140997 histone H4 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0140998 histone H2B kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:1990244 histone H2AT120 kinase activity 35/1817 245/18639 0.142857142857143 1.46544539665068 0.0138597603513261 0.079677200503121 GO:0140034 methylation-dependent protein binding 14/1817 76/18639 0.184210526315789 1.88965327462851 0.0142774771484487 0.081691414061643 GO:0004677 DNA-dependent protein kinase activity 35/1817 246/18639 0.142276422764228 1.45948830154234 0.0146910080290457 0.0832719286880019 GO:0140857 histone H3T45 kinase activity 35/1817 246/18639 0.142276422764228 1.45948830154234 0.0146910080290457 0.0832719286880019 GO:0001727 lipid kinase activity 9/1817 41/18639 0.219512195121951 2.25178195095104 0.0154546277908016 0.0867030473646338 GO:0022804 active transmembrane transporter activity 59/1817 457/18639 0.12910284463895 1.3243521855946 0.015490446999254 0.0867030473646338 GO:0019789 SUMO transferase activity 7/1817 28/18639 0.25 2.56452944413869 0.0156537241326091 0.0867030473646338 GO:0036408 histone H3K14 acetyltransferase activity 7/1817 28/18639 0.25 2.56452944413869 0.0156537241326091 0.0867030473646338 GO:0051393 alpha-actinin binding 7/1817 28/18639 0.25 2.56452944413869 0.0156537241326091 0.0867030473646338 GO:0140693 molecular condensate scaffold activity 10/1817 48/18639 0.208333333333333 2.13710787011558 0.0157949890205098 0.0870878258267198 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/1817 22/18639 0.272727272727273 2.79766848451493 0.016151617099639 0.0882518537921716 GO:0140517 protein-RNA adaptor activity 6/1817 22/18639 0.272727272727273 2.79766848451493 0.016151617099639 0.0882518537921716 GO:0050786 RAGE receptor binding 4/1817 11/18639 0.363636363636364 3.73022464601991 0.0169578347246037 0.091829703218501 GO:1990948 ubiquitin ligase inhibitor activity 4/1817 11/18639 0.363636363636364 3.73022464601991 0.0169578347246037 0.091829703218501 GO:0010485 histone H4 acetyltransferase activity 8/1817 35/18639 0.228571428571429 2.34471263464109 0.0172737533486826 0.0931247236086757 GO:0010484 histone H3 acetyltransferase activity 7/1817 29/18639 0.241379310344828 2.4760973943408 0.018942630598093 0.101669959803039 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/1817 17/18639 0.294117647058824 3.01709346369258 0.0199650959183426 0.105294179778042 GO:0008429 phosphatidylethanolamine binding 5/1817 17/18639 0.294117647058824 3.01709346369258 0.0199650959183426 0.105294179778042 GO:0015278 intracellularly gated calcium channel activity 5/1817 17/18639 0.294117647058824 3.01709346369258 0.0199650959183426 0.105294179778042 GO:0019198 transmembrane receptor protein phosphatase activity 5/1817 17/18639 0.294117647058824 3.01709346369258 0.0199650959183426 0.105294179778042 GO:0005158 insulin receptor binding 6/1817 23/18639 0.260869565217391 2.67603072431863 0.0200929424940875 0.105509693702719 GO:0038024 cargo receptor activity 12/1817 65/18639 0.184615384615385 1.89380635874857 0.021938243790612 0.114702972922467 GO:0043995 histone H4K5 acetyltransferase activity 7/1817 30/18639 0.233333333333333 2.39356081452944 0.0226861888299547 0.117099349152064 GO:0043996 histone H4K8 acetyltransferase activity 7/1817 30/18639 0.233333333333333 2.39356081452944 0.0226861888299547 0.117099349152064 GO:0043997 histone H4K12 acetyltransferase activity 7/1817 30/18639 0.233333333333333 2.39356081452944 0.0226861888299547 0.117099349152064 GO:0016407 acetyltransferase activity 16/1817 96/18639 0.166666666666667 1.70968629609246 0.0228890703959166 0.117645942331554 GO:0005200 structural constituent of cytoskeleton 18/1817 112/18639 0.160714285714286 1.64862607123202 0.0232422716676566 0.118811920780077 GO:0034452 dynactin binding 4/1817 12/18639 0.333333333333333 3.41937259218492 0.0235077172194711 0.118811920780077 GO:0035497 cAMP response element binding 4/1817 12/18639 0.333333333333333 3.41937259218492 0.0235077172194711 0.118811920780077 GO:0070410 co-SMAD binding 4/1817 12/18639 0.333333333333333 3.41937259218492 0.0235077172194711 0.118811920780077 GO:0001223 transcription coactivator binding 9/1817 44/18639 0.204545454545455 2.0982513633862 0.0240400840250936 0.120998431213438 GO:0000900 mRNA regulatory element binding translation repressor activity 5/1817 18/18639 0.277777777777778 2.8494771601541 0.0254771504005492 0.126654850146992 GO:0030228 lipoprotein particle receptor activity 5/1817 18/18639 0.277777777777778 2.8494771601541 0.0254771504005492 0.126654850146992 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/1817 18/18639 0.277777777777778 2.8494771601541 0.0254771504005492 0.126654850146992 GO:0035064 methylated histone binding 13/1817 74/18639 0.175675675675676 1.80210177155692 0.0256790341418337 0.127037793195867 GO:0045309 protein phosphorylated amino acid binding 11/1817 59/18639 0.186440677966102 1.91253043291699 0.0257636414890217 0.127037793195867 GO:0004714 transmembrane receptor protein tyrosine kinase activity 11/1817 60/18639 0.183333333333333 1.88065492570171 0.028864138242011 0.141749796305908 GO:0001540 amyloid-beta binding 14/1817 83/18639 0.168674698795181 1.73028492616586 0.0291043732849576 0.142353245139732 GO:0072341 modified amino acid binding 15/1817 91/18639 0.164835164835165 1.69089853459694 0.029524410167101 0.143295890604157 GO:0017124 SH3 domain binding 18/1817 115/18639 0.156521739130435 1.60561843459118 0.0295333657469408 0.143295890604157 GO:0019902 phosphatase binding 27/1817 190/18639 0.142105263157895 1.45773252614199 0.0296616552464098 0.1433449713701 GO:0034212 protein N-acetyltransferase activity 10/1817 53/18639 0.188679245283019 1.93549392010467 0.030268265738076 0.145357952521133 GO:0032934 sterol binding 12/1817 68/18639 0.176470588235294 1.81025607821555 0.0303178581927838 0.145357952521133 GO:0098631 cell adhesion mediator activity 13/1817 76/18639 0.171052631578947 1.75467804072647 0.0312998740854939 0.148160057533215 GO:0005035 death receptor activity 4/1817 13/18639 0.307692307692308 3.15634393124762 0.0313908778120662 0.148160057533215 GO:0051011 microtubule minus-end binding 4/1817 13/18639 0.307692307692308 3.15634393124762 0.0313908778120662 0.148160057533215 GO:0097157 pre-mRNA intronic binding 4/1817 13/18639 0.307692307692308 3.15634393124762 0.0313908778120662 0.148160057533215 GO:0071813 lipoprotein particle binding 7/1817 32/18639 0.21875 2.24396326362135 0.031639112868679 0.148178547913929 GO:0071814 protein-lipid complex binding 7/1817 32/18639 0.21875 2.24396326362135 0.031639112868679 0.148178547913929 GO:1990380 K48-linked deubiquitinase activity 5/1817 19/18639 0.263157894736842 2.69950467804073 0.0318744523263527 0.148706579507176 GO:0061134 peptidase regulator activity 31/1817 226/18639 0.13716814159292 1.40708695165132 0.0324911059366762 0.151002726058192 GO:0017069 snRNA binding 10/1817 54/18639 0.185185185185185 1.89965144010273 0.0340185317172209 0.157498011347286 GO:0051219 phosphoprotein binding 15/1817 93/18639 0.161290322580645 1.65453512525077 0.035076376346072 0.161457989395286 GO:0005543 phospholipid binding 61/1817 497/18639 0.122736418511066 1.25904463655903 0.0354900808458022 0.161457989395286 GO:0061733 protein-lysine-acetyltransferase activity 9/1817 47/18639 0.191489361702128 1.96432042529772 0.0355675395857204 0.161457989395286 GO:0043548 phosphatidylinositol 3-kinase binding 6/1817 26/18639 0.230769230769231 2.36725794843571 0.0356724988936 0.161457989395286 GO:0070006 metalloaminopeptidase activity 6/1817 26/18639 0.230769230769231 2.36725794843571 0.0356724988936 0.161457989395286 GO:0070412 R-SMAD binding 6/1817 26/18639 0.230769230769231 2.36725794843571 0.0356724988936 0.161457989395286 GO:0030331 nuclear estrogen receptor binding 8/1817 40/18639 0.2 2.05162355531095 0.0366482517128962 0.164645664176826 GO:0050997 quaternary ammonium group binding 8/1817 40/18639 0.2 2.05162355531095 0.0366482517128962 0.164645664176826 GO:0019199 transmembrane receptor protein kinase activity 13/1817 78/18639 0.166666666666667 1.70968629609246 0.0377600799346698 0.169014675131935 GO:0008238 exopeptidase activity 16/1817 102/18639 0.156862745098039 1.60911651396937 0.0379185677333233 0.169100083310739 GO:0042562 hormone binding 15/1817 94/18639 0.159574468085106 1.6369336877481 0.0381194988474818 0.16937345092306 GO:0042288 MHC class I protein binding 5/1817 20/18639 0.25 2.56452944413869 0.0391891360521284 0.17349059135486 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/1817 48/18639 0.1875 1.92339708310402 0.0401304358699998 0.177011704401126 GO:0034236 protein kinase A catalytic subunit binding 4/1817 14/18639 0.285714285714286 2.93089079330136 0.0406414658479458 0.177971473189741 GO:0061665 SUMO ligase activity 4/1817 14/18639 0.285714285714286 2.93089079330136 0.0406414658479458 0.177971473189741 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/1817 41/18639 0.195121951219512 2.00158395640093 0.0417860999364343 0.182325680657895 GO:0005044 scavenger receptor activity 6/1817 27/18639 0.222222222222222 2.27958172812328 0.0422100158625269 0.183515230255359 GO:0090482 vitamin transmembrane transporter activity 7/1817 34/18639 0.205882352941176 2.1119654245848 0.0426893784567751 0.184936485957386 GO:0016504 peptidase activator activity 10/1817 57/18639 0.175438596491228 1.79966978536048 0.0471835817173189 0.202633614566557 GO:0004402 histone acetyltransferase activity 8/1817 42/18639 0.19047619047619 1.95392719553424 0.0473790996372627 0.202633614566557 GO:0042056 chemoattractant activity 8/1817 42/18639 0.19047619047619 1.95392719553424 0.0473790996372627 0.202633614566557 GO:0051010 microtubule plus-end binding 5/1817 21/18639 0.238095238095238 2.4424089944178 0.0474426599644702 0.202633614566557 GO:0043539 protein serine/threonine kinase activator activity 12/1817 73/18639 0.164383561643836 1.68626593587202 0.0490246331696331 0.208655719420228 GO:0097718 disordered domain specific binding 6/1817 28/18639 0.214285714285714 2.19816809497602 0.0494526408797772 0.209010638979685 GO:0141052 histone H3 demethylase activity 6/1817 28/18639 0.214285714285714 2.19816809497602 0.0494526408797772 0.209010638979685 GO:0004559 alpha-mannosidase activity 4/1817 15/18639 0.266666666666667 2.73549807374794 0.0512688845414364 0.215934572738758 GO:0000993 RNA polymerase II complex binding 7/1817 36/18639 0.194444444444444 1.99463401210787 0.0559657162660816 0.234002977301011 GO:0055106 ubiquitin-protein transferase regulator activity 7/1817 36/18639 0.194444444444444 1.99463401210787 0.0559657162660816 0.234002977301011 GO:0005021 vascular endothelial growth factor receptor activity 9/1817 51/18639 0.176470588235294 1.81025607821555 0.0561375650408856 0.234002977301011 GO:0140035 ubiquitin-like protein reader activity 5/1817 22/18639 0.227272727272727 2.33139040376245 0.0566459078658911 0.23469215640575 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 23/1817 167/18639 0.137724550898204 1.41279466383688 0.0566898613576955 0.23469215640575 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/1817 29/18639 0.206896551724138 2.12236919514926 0.0574117739967382 0.236872387272257 GO:0001786 phosphatidylserine binding 10/1817 59/18639 0.169491525423729 1.73866402992454 0.0576436800449381 0.237022996252576 GO:0019208 phosphatase regulator activity 17/1817 117/18639 0.145299145299145 1.49049574531138 0.0614748371340084 0.251922221093082 GO:0051117 ATPase binding 13/1817 84/18639 0.154761904761905 1.58756584637157 0.0626870713441231 0.253248646739324 GO:0008168 methyltransferase activity 27/1817 204/18639 0.132352941176471 1.35769205866166 0.0628098121949404 0.253248646739324 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/1817 16/18639 0.25 2.56452944413869 0.0632599669925929 0.253248646739324 GO:0005521 lamin binding 4/1817 16/18639 0.25 2.56452944413869 0.0632599669925929 0.253248646739324 GO:0008142 oxysterol binding 4/1817 16/18639 0.25 2.56452944413869 0.0632599669925929 0.253248646739324 GO:0015923 mannosidase activity 4/1817 16/18639 0.25 2.56452944413869 0.0632599669925929 0.253248646739324 GO:0034450 ubiquitin-ubiquitin ligase activity 4/1817 16/18639 0.25 2.56452944413869 0.0632599669925929 0.253248646739324 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:0008239 dipeptidyl-peptidase activity 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:0030957 Tat protein binding 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:0140940 histone H2A methyltransferase activity 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:0140999 histone H3K4 trimethyltransferase activity 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:1990259 histone H2AQ104 methyltransferase activity 3/1817 10/18639 0.3 3.07743533296643 0.0658748282554812 0.257761827980318 GO:0032452 histone demethylase activity 6/1817 30/18639 0.2 2.05162355531095 0.0660931702884341 0.257784615948137 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 34/1817 268/18639 0.126865671641791 1.30140300150322 0.066959714446937 0.259588460302296 GO:0051539 4 iron, 4 sulfur cluster binding 8/1817 45/18639 0.177777777777778 1.82366538249862 0.0669836670029831 0.259588460302296 GO:0008080 N-acetyltransferase activity 11/1817 69/18639 0.159420289855072 1.63535210930583 0.0694115164569802 0.268140667077442 GO:0032182 ubiquitin-like protein binding 17/1817 120/18639 0.141666666666667 1.45323335167859 0.0743769085165756 0.284999727643782 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 8/1817 46/18639 0.173913043478261 1.78402048287909 0.0744805553693973 0.284999727643782 GO:0030276 clathrin binding 8/1817 46/18639 0.173913043478261 1.78402048287909 0.0744805553693973 0.284999727643782 GO:0030246 carbohydrate binding 35/1817 280/18639 0.125 1.28226472206935 0.0753753086266597 0.287077984596994 GO:0140457 protein demethylase activity 6/1817 31/18639 0.193548387096774 1.98544215030092 0.0754970132616991 0.287077984596994 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 9/1817 54/18639 0.166666666666667 1.70968629609246 0.075780896273477 0.287256959936649 GO:0061659 ubiquitin-like protein ligase activity 45/1817 372/18639 0.120967741935484 1.24090134393808 0.0760535911841649 0.287392542387514 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/1817 17/18639 0.235294117647059 2.41367477095406 0.0765814657846698 0.287595411754813 GO:0046965 nuclear retinoid X receptor binding 4/1817 17/18639 0.235294117647059 2.41367477095406 0.0765814657846698 0.287595411754813 GO:0030215 semaphorin receptor binding 5/1817 24/18639 0.208333333333333 2.13710787011558 0.0778943393512475 0.289833845500194 GO:0035035 histone acetyltransferase binding 5/1817 24/18639 0.208333333333333 2.13710787011558 0.0778943393512475 0.289833845500194 GO:0070840 dynein complex binding 5/1817 24/18639 0.208333333333333 2.13710787011558 0.0778943393512475 0.289833845500194 GO:0004896 cytokine receptor activity 14/1817 96/18639 0.145833333333333 1.4959755090809 0.0819237330038363 0.303894459124322 GO:0070851 growth factor receptor binding 19/1817 139/18639 0.136690647482014 1.40218876082403 0.082284235077712 0.304301149845319 GO:0016755 aminoacyltransferase activity 58/1817 496/18639 0.116935483870968 1.19953796580681 0.0827403176072438 0.305057766740385 GO:0098632 cell-cell adhesion mediator activity 9/1817 55/18639 0.163636363636364 1.67860109070896 0.0831569062762173 0.30526440646017 GO:0005536 D-glucose binding 3/1817 11/18639 0.272727272727273 2.79766848451493 0.0842187008295604 0.30526440646017 GO:0008432 JUN kinase binding 3/1817 11/18639 0.272727272727273 2.79766848451493 0.0842187008295604 0.30526440646017 GO:0019107 myristoyltransferase activity 3/1817 11/18639 0.272727272727273 2.79766848451493 0.0842187008295604 0.30526440646017 GO:0048185 activin binding 3/1817 11/18639 0.272727272727273 2.79766848451493 0.0842187008295604 0.30526440646017 GO:0004197 cysteine-type endopeptidase activity 13/1817 88/18639 0.147727272727273 1.51540376244559 0.0843063282474502 0.30526440646017 GO:0019787 ubiquitin-like protein transferase activity 56/1817 479/18639 0.116910229645094 1.19927890498344 0.0871395335103914 0.314584089726502 GO:0035091 phosphatidylinositol binding 35/1817 284/18639 0.123239436619718 1.26420465556133 0.0878652126595926 0.316262620047732 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/1817 40/18639 0.175 1.79517061089708 0.0894431904474735 0.319834161146637 GO:0015662 P-type ion transporter activity 5/1817 25/18639 0.2 2.05162355531095 0.0899121590692525 0.319834161146637 GO:0120020 cholesterol transfer activity 5/1817 25/18639 0.2 2.05162355531095 0.0899121590692525 0.319834161146637 GO:0140358 P-type transmembrane transporter activity 5/1817 25/18639 0.2 2.05162355531095 0.0899121590692525 0.319834161146637 GO:0003746 translation elongation factor activity 4/1817 18/18639 0.222222222222222 2.27958172812328 0.0911826987515614 0.320593082856939 GO:0017075 syntaxin-1 binding 4/1817 18/18639 0.222222222222222 2.27958172812328 0.0911826987515614 0.320593082856939 GO:0035615 clathrin adaptor activity 4/1817 18/18639 0.222222222222222 2.27958172812328 0.0911826987515614 0.320593082856939 GO:0098641 cadherin binding involved in cell-cell adhesion 4/1817 18/18639 0.222222222222222 2.27958172812328 0.0911826987515614 0.320593082856939 GO:0030296 protein tyrosine kinase activator activity 6/1817 33/18639 0.181818181818182 1.86511232300996 0.0964458980259507 0.337143729986969 GO:0071889 14-3-3 protein binding 6/1817 33/18639 0.181818181818182 1.86511232300996 0.0964458980259507 0.337143729986969 GO:0001217 DNA-binding transcription repressor activity 34/1817 278/18639 0.122302158273381 1.25458994389519 0.0988464511825768 0.344542371507085 GO:0016877 ligase activity, forming carbon-sulfur bonds 7/1817 41/18639 0.170731707317073 1.75138596185081 0.0992549443762167 0.344974921284673 GO:0005496 steroid binding 15/1817 108/18639 0.138888888888889 1.42473858007705 0.101962991365996 0.350982710468891 GO:0030247 polysaccharide binding 5/1817 26/18639 0.192307692307692 1.97271495702976 0.102826363872979 0.350982710468891 GO:0034237 protein kinase A regulatory subunit binding 5/1817 26/18639 0.192307692307692 1.97271495702976 0.102826363872979 0.350982710468891 GO:0016741 transferase activity, transferring one-carbon groups 27/1817 215/18639 0.125581395348837 1.28822874403246 0.102838494620662 0.350982710468891 GO:0004875 complement receptor activity 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0005078 MAP-kinase scaffold activity 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0005095 GTPase inhibitor activity 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0008603 cAMP-dependent protein kinase regulator activity 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0016208 AMP binding 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0017166 vinculin binding 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0036009 protein-glutamine N-methyltransferase activity 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/1817 12/18639 0.25 2.56452944413869 0.104455695366257 0.350982710468891 GO:0008235 metalloexopeptidase activity 10/1817 66/18639 0.151515151515152 1.55426026917496 0.105509481725545 0.352287295126415 GO:0043130 ubiquitin binding 14/1817 100/18639 0.14 1.43613648871767 0.105999671728142 0.352287295126415 GO:0015245 fatty acid transmembrane transporter activity 4/1817 19/18639 0.210526315789474 2.15960374243258 0.106998231131617 0.352287295126415 GO:0030506 ankyrin binding 4/1817 19/18639 0.210526315789474 2.15960374243258 0.106998231131617 0.352287295126415 GO:0034987 immunoglobulin receptor binding 4/1817 19/18639 0.210526315789474 2.15960374243258 0.106998231131617 0.352287295126415 GO:0043395 heparan sulfate proteoglycan binding 4/1817 19/18639 0.210526315789474 2.15960374243258 0.106998231131617 0.352287295126415 GO:0140036 ubiquitin-modified protein reader activity 4/1817 19/18639 0.210526315789474 2.15960374243258 0.106998231131617 0.352287295126415 GO:0019903 protein phosphatase binding 19/1817 144/18639 0.131944444444444 1.3535016510732 0.107167363480336 0.352287295126415 GO:0005006 epidermal growth factor receptor activity 8/1817 50/18639 0.16 1.64129884424876 0.109299545424795 0.357359430189423 GO:0032813 tumor necrosis factor receptor superfamily binding 8/1817 50/18639 0.16 1.64129884424876 0.109299545424795 0.357359430189423 GO:0043175 RNA polymerase core enzyme binding 7/1817 42/18639 0.166666666666667 1.70968629609246 0.109630113324008 0.357476686725863 GO:0019783 ubiquitin-like protein peptidase activity 17/1817 127/18639 0.133858267716535 1.37313387560182 0.111075227905418 0.361217832303679 GO:0004860 protein kinase inhibitor activity 12/1817 84/18639 0.142857142857143 1.46544539665068 0.114264092007399 0.370594501617581 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/1817 27/18639 0.185185185185185 1.89965144010273 0.116602806602628 0.374793100907054 GO:0015252 proton channel activity 5/1817 27/18639 0.185185185185185 1.89965144010273 0.116602806602628 0.374793100907054 GO:0016405 CoA-ligase activity 5/1817 27/18639 0.185185185185185 1.89965144010273 0.116602806602628 0.374793100907054 GO:0036002 pre-mRNA binding 9/1817 59/18639 0.152542372881356 1.56479762693208 0.116794552467326 0.374793100907054 GO:0051213 dioxygenase activity 13/1817 93/18639 0.139784946236559 1.433930441884 0.117218887971532 0.375162298441868 GO:0003743 translation initiation factor activity 8/1817 51/18639 0.156862745098039 1.60911651396937 0.119190146426452 0.379468891378705 GO:0005010 insulin-like growth factor receptor activity 8/1817 51/18639 0.156862745098039 1.60911651396937 0.119190146426452 0.379468891378705 GO:0140566 histone reader activity 6/1817 35/18639 0.171428571428571 1.75853447598082 0.120155883423252 0.381542111498441 GO:0016505 peptidase activator activity involved in apoptotic process 4/1817 20/18639 0.2 2.05162355531095 0.123950504901489 0.38808365971453 GO:0043024 ribosomal small subunit binding 4/1817 20/18639 0.2 2.05162355531095 0.123950504901489 0.38808365971453 GO:0140939 histone H4 methyltransferase activity 4/1817 20/18639 0.2 2.05162355531095 0.123950504901489 0.38808365971453 GO:0140375 immune receptor activity 20/1817 156/18639 0.128205128205128 1.31514330468651 0.124185550632458 0.38808365971453 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/1817 60/18639 0.15 1.53871766648321 0.126217193184115 0.38808365971453 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0005542 folic acid binding 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0008035 high-density lipoprotein particle binding 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0032396 inhibitory MHC class I receptor activity 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0035325 Toll-like receptor binding 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0035673 oligopeptide transmembrane transporter activity 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0039706 co-receptor binding 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0070700 BMP receptor binding 3/1817 13/18639 0.230769230769231 2.36725794843571 0.126375140632514 0.38808365971453 GO:0008237 metallopeptidase activity 23/1817 184/18639 0.125 1.28226472206935 0.128691390791279 0.393205685213656 GO:0061135 endopeptidase regulator activity 23/1817 184/18639 0.125 1.28226472206935 0.128691390791279 0.393205685213656 GO:0045499 chemorepellent activity 5/1817 28/18639 0.178571428571429 1.83180674581335 0.131200668716291 0.399347890101859 GO:0001046 core promoter sequence-specific DNA binding 7/1817 44/18639 0.159090909090909 1.63197328263371 0.132018552292535 0.399347890101859 GO:0019205 nucleobase-containing compound kinase activity 7/1817 44/18639 0.159090909090909 1.63197328263371 0.132018552292535 0.399347890101859 GO:0043014 alpha-tubulin binding 7/1817 44/18639 0.159090909090909 1.63197328263371 0.132018552292535 0.399347890101859 GO:0017046 peptide hormone binding 8/1817 53/18639 0.150943396226415 1.54839513608374 0.140332876203485 0.423442235907531 GO:0005123 death receptor binding 4/1817 21/18639 0.19047619047619 1.95392719553424 0.141952350769023 0.426208419511943 GO:0140312 cargo adaptor activity 4/1817 21/18639 0.19047619047619 1.95392719553424 0.141952350769023 0.426208419511943 GO:0008234 cysteine-type peptidase activity 23/1817 187/18639 0.122994652406417 1.26169363027144 0.145427376002104 0.435563968124819 GO:0023023 MHC protein complex binding 6/1817 37/18639 0.162162162162162 1.66347855836023 0.146451242096544 0.435768332735166 GO:0051861 glycolipid binding 5/1817 29/18639 0.172413793103448 1.76864099595772 0.146573355116198 0.435768332735166 GO:0099604 ligand-gated calcium channel activity 5/1817 29/18639 0.172413793103448 1.76864099595772 0.146573355116198 0.435768332735166 GO:0030414 peptidase inhibitor activity 21/1817 169/18639 0.124260355029586 1.27467735685 0.147471623316523 0.437366941523087 GO:0008013 beta-catenin binding 14/1817 106/18639 0.132075471698113 1.35484574407327 0.149263528431746 0.43904536234527 GO:0005344 oxygen carrier activity 3/1817 14/18639 0.214285714285714 2.19816809497602 0.149757051937396 0.43904536234527 GO:0005347 ATP transmembrane transporter activity 3/1817 14/18639 0.214285714285714 2.19816809497602 0.149757051937396 0.43904536234527 GO:0008195 phosphatidate phosphatase activity 3/1817 14/18639 0.214285714285714 2.19816809497602 0.149757051937396 0.43904536234527 GO:0101005 deubiquitinase activity 15/1817 115/18639 0.130434782608696 1.33801536215932 0.149847304213472 0.43904536234527 GO:0015485 cholesterol binding 8/1817 54/18639 0.148148148148148 1.51972115208219 0.15155930749566 0.442991421668039 GO:0004866 endopeptidase inhibitor activity 20/1817 161/18639 0.124223602484472 1.27430034491363 0.154753697271278 0.451240949014569 GO:0003727 single-stranded RNA binding 12/1817 89/18639 0.134831460674157 1.38311700358042 0.155314847637587 0.451791151521325 GO:0030291 protein serine/threonine kinase inhibitor activity 7/1817 46/18639 0.152173913043478 1.5610179225192 0.156476271755957 0.453291937828299 GO:0042626 ATPase-coupled transmembrane transporter activity 13/1817 98/18639 0.13265306122449 1.36077072546135 0.156578171434507 0.453291937828299 GO:0019888 protein phosphatase regulator activity 14/1817 107/18639 0.130841121495327 1.34218363431558 0.157281554403132 0.454244108311902 GO:0042887 amide transmembrane transporter activity 6/1817 38/18639 0.157894736842105 1.61970280682444 0.160496425546297 0.459948654067979 GO:0008093 cytoskeletal anchor activity 4/1817 22/18639 0.181818181818182 1.86511232300996 0.160909338080831 0.459948654067979 GO:0016881 acid-amino acid ligase activity 4/1817 22/18639 0.181818181818182 1.86511232300996 0.160909338080831 0.459948654067979 GO:0070034 telomerase RNA binding 4/1817 22/18639 0.181818181818182 1.86511232300996 0.160909338080831 0.459948654067979 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/1817 30/18639 0.166666666666667 1.70968629609246 0.16266939208175 0.459948654067979 GO:0008187 poly-pyrimidine tract binding 5/1817 30/18639 0.166666666666667 1.70968629609246 0.16266939208175 0.459948654067979 GO:0015215 nucleotide transmembrane transporter activity 5/1817 30/18639 0.166666666666667 1.70968629609246 0.16266939208175 0.459948654067979 GO:0031210 phosphatidylcholine binding 5/1817 30/18639 0.166666666666667 1.70968629609246 0.16266939208175 0.459948654067979 GO:0098918 structural constituent of synapse 5/1817 30/18639 0.166666666666667 1.70968629609246 0.16266939208175 0.459948654067979 GO:0140313 molecular sequestering activity 8/1817 55/18639 0.145454545454545 1.49208985840797 0.163202269405353 0.460382215787658 GO:0019210 kinase inhibitor activity 12/1817 90/18639 0.133333333333333 1.36774903687397 0.164335071529127 0.462502185069213 GO:0004843 cysteine-type deubiquitinase activity 14/1817 108/18639 0.12962962962963 1.32975600807191 0.165520489323556 0.464760077660819 GO:0005504 fatty acid binding 7/1817 47/18639 0.148936170212766 1.52780477523156 0.169428644633934 0.474634979078435 GO:0031005 filamin binding 3/1817 15/18639 0.2 2.05162355531095 0.174379093786386 0.486257105202038 GO:0061578 K63-linked deubiquitinase activity 3/1817 15/18639 0.2 2.05162355531095 0.174379093786386 0.486257105202038 GO:0000217 DNA secondary structure binding 6/1817 39/18639 0.153846153846154 1.57817196562381 0.175095034524002 0.487133662563335 GO:0004842 ubiquitin-protein transferase activity 50/1817 449/18639 0.111358574610245 1.14232937378115 0.177145431161538 0.49089797512706 GO:0061630 ubiquitin protein ligase activity 40/1817 353/18639 0.113314447592068 1.16239294918468 0.17725747164522 0.49089797512706 GO:0005164 tumor necrosis factor receptor binding 5/1817 31/18639 0.161290322580645 1.65453512525077 0.179433311085606 0.493912028572407 GO:0016878 acid-thiol ligase activity 5/1817 31/18639 0.161290322580645 1.65453512525077 0.179433311085606 0.493912028572407 GO:0042277 peptide binding 29/1817 249/18639 0.116465863453815 1.19472054425738 0.180169149769827 0.493912028572407 GO:0004602 glutathione peroxidase activity 4/1817 23/18639 0.173913043478261 1.78402048287909 0.180721933601414 0.493912028572407 GO:0099186 structural constituent of postsynapse 4/1817 23/18639 0.173913043478261 1.78402048287909 0.180721933601414 0.493912028572407 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 16/1817 128/18639 0.125 1.28226472206935 0.180788904110592 0.493912028572407 GO:0032451 demethylase activity 6/1817 40/18639 0.15 1.53871766648321 0.190210065831624 0.518482718772495 GO:1902936 phosphatidylinositol bisphosphate binding 14/1817 111/18639 0.126126126126126 1.2938166565024 0.191512512233522 0.518970195293051 GO:0004175 endopeptidase activity 45/1817 405/18639 0.111111111111111 1.13979086406164 0.195877929567311 0.518970195293051 GO:0005004 GPI-linked ephrin receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0005008 hepatocyte growth factor receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0005009 insulin receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0005011 macrophage colony-stimulating factor receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0005020 stem cell factor receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0008288 boss receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0036332 placental growth factor receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0038062 protein tyrosine kinase collagen receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0060175 brain-derived neurotrophic factor receptor activity 7/1817 49/18639 0.142857142857143 1.46544539665068 0.196656721412109 0.518970195293051 GO:0022884 macromolecule transmembrane transporter activity 5/1817 32/18639 0.15625 1.60283090258668 0.196806504398024 0.518970195293051 GO:0030515 snoRNA binding 5/1817 32/18639 0.15625 1.60283090258668 0.196806504398024 0.518970195293051 GO:0120015 sterol transfer activity 5/1817 32/18639 0.15625 1.60283090258668 0.196806504398024 0.518970195293051 GO:0015562 efflux transmembrane transporter activity 3/1817 16/18639 0.1875 1.92339708310402 0.200021969200338 0.519492935794906 GO:0022858 alanine transmembrane transporter activity 3/1817 16/18639 0.1875 1.92339708310402 0.200021969200338 0.519492935794906 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/1817 16/18639 0.1875 1.92339708310402 0.200021969200338 0.519492935794906 GO:0015149 hexose transmembrane transporter activity 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0015295 solute:proton symporter activity 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0055056 D-glucose transmembrane transporter activity 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0070300 phosphatidic acid binding 4/1817 24/18639 0.166666666666667 1.70968629609246 0.201287452451448 0.519492935794906 GO:0016410 N-acyltransferase activity 12/1817 94/18639 0.127659574468085 1.30954695019848 0.202899293263228 0.522541067363685 GO:0017080 sodium channel regulator activity 6/1817 41/18639 0.146341463414634 1.5011879673007 0.205802372366837 0.527776485583453 GO:0042169 SH2 domain binding 6/1817 41/18639 0.146341463414634 1.5011879673007 0.205802372366837 0.527776485583453 GO:0016791 phosphatase activity 31/1817 273/18639 0.113553113553114 1.16484121272234 0.209262558030613 0.535135142232289 GO:0005007 fibroblast growth factor receptor activity 7/1817 50/18639 0.14 1.43613648871767 0.21087765703795 0.535135142232289 GO:0005017 platelet-derived growth factor receptor activity 7/1817 50/18639 0.14 1.43613648871767 0.21087765703795 0.535135142232289 GO:0005019 platelet-derived growth factor beta-receptor activity 7/1817 50/18639 0.14 1.43613648871767 0.21087765703795 0.535135142232289 GO:0015605 organophosphate ester transmembrane transporter activity 7/1817 50/18639 0.14 1.43613648871767 0.21087765703795 0.535135142232289 GO:0004867 serine-type endopeptidase inhibitor activity 12/1817 95/18639 0.126315789473684 1.29576224545955 0.213119840113932 0.537345587668705 GO:0004879 nuclear receptor activity 8/1817 59/18639 0.135593220338983 1.39093122393963 0.213573250376631 0.537345587668705 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 11/1817 86/18639 0.127906976744186 1.31208483188491 0.214243533830821 0.537345587668705 GO:0016209 antioxidant activity 11/1817 86/18639 0.127906976744186 1.31208483188491 0.214243533830821 0.537345587668705 GO:0140416 transcription regulator inhibitor activity 5/1817 33/18639 0.151515151515152 1.55426026917496 0.21472804125018 0.537345587668705 GO:1990841 promoter-specific chromatin binding 9/1817 68/18639 0.132352941176471 1.35769205866166 0.214730929139517 0.537345587668705 GO:0051540 metal cluster binding 10/1817 77/18639 0.12987012987013 1.33222308786425 0.214849637278913 0.537345587668705 GO:0048487 beta-tubulin binding 6/1817 42/18639 0.142857142857143 1.46544539665068 0.221831082207309 0.549683658208333 GO:0015645 fatty acid ligase activity 4/1817 25/18639 0.16 1.64129884424876 0.222501794048056 0.549683658208333 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/1817 25/18639 0.16 1.64129884424876 0.222501794048056 0.549683658208333 GO:0019707 protein-cysteine S-acyltransferase activity 4/1817 25/18639 0.16 1.64129884424876 0.222501794048056 0.549683658208333 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/1817 25/18639 0.16 1.64129884424876 0.222501794048056 0.549683658208333 GO:0120515 fatty acid-CoA ligase activity 4/1817 25/18639 0.16 1.64129884424876 0.222501794048056 0.549683658208333 GO:0005030 neurotrophin receptor activity 7/1817 51/18639 0.137254901960784 1.4079769497232 0.225464306453416 0.551631249697327 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/1817 17/18639 0.176470588235294 1.81025607821555 0.226473505646553 0.551631249697327 GO:0005092 GDP-dissociation inhibitor activity 3/1817 17/18639 0.176470588235294 1.81025607821555 0.226473505646553 0.551631249697327 GO:0016018 cyclosporin A binding 3/1817 17/18639 0.176470588235294 1.81025607821555 0.226473505646553 0.551631249697327 GO:0032183 SUMO binding 3/1817 17/18639 0.176470588235294 1.81025607821555 0.226473505646553 0.551631249697327 GO:0032977 membrane insertase activity 3/1817 17/18639 0.176470588235294 1.81025607821555 0.226473505646553 0.551631249697327 GO:0048038 quinone binding 3/1817 17/18639 0.176470588235294 1.81025607821555 0.226473505646553 0.551631249697327 GO:0098531 ligand-modulated transcription factor activity 8/1817 60/18639 0.133333333333333 1.36774903687397 0.227012643790865 0.551836346529697 GO:0008376 acetylgalactosaminyltransferase activity 5/1817 34/18639 0.147058823529412 1.50854673184629 0.233135435910669 0.565404112045993 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 26/1817 229/18639 0.11353711790393 1.1646771274691 0.233728745889169 0.565404112045993 GO:0003774 cytoskeletal motor activity 18/1817 153/18639 0.117647058823529 1.20683738547703 0.233992468464211 0.565404112045993 GO:0005160 transforming growth factor beta receptor binding 4/1817 26/18639 0.153846153846154 1.57817196562381 0.244260963170797 0.583245173870426 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/1817 26/18639 0.153846153846154 1.57817196562381 0.244260963170797 0.583245173870426 GO:0008157 protein phosphatase 1 binding 4/1817 26/18639 0.153846153846154 1.57817196562381 0.244260963170797 0.583245173870426 GO:0015145 monosaccharide transmembrane transporter activity 4/1817 26/18639 0.153846153846154 1.57817196562381 0.244260963170797 0.583245173870426 GO:0015216 purine nucleotide transmembrane transporter activity 4/1817 26/18639 0.153846153846154 1.57817196562381 0.244260963170797 0.583245173870426 GO:0030507 spectrin binding 4/1817 26/18639 0.153846153846154 1.57817196562381 0.244260963170797 0.583245173870426 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/1817 18/18639 0.166666666666667 1.70968629609246 0.253531667025551 0.583881959220848 GO:0032393 MHC class I receptor activity 3/1817 18/18639 0.166666666666667 1.70968629609246 0.253531667025551 0.583881959220848 GO:0034185 apolipoprotein binding 3/1817 18/18639 0.166666666666667 1.70968629609246 0.253531667025551 0.583881959220848 GO:0070064 proline-rich region binding 3/1817 18/18639 0.166666666666667 1.70968629609246 0.253531667025551 0.583881959220848 GO:0000182 rDNA binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0005522 profilin binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0005528 FK506 binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0008190 eukaryotic initiation factor 4E binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0031434 mitogen-activated protein kinase kinase binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0031720 haptoglobin binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0035256 G protein-coupled glutamate receptor binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0070513 death domain binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0098505 G-rich strand telomeric DNA binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0099122 RNA polymerase II C-terminal domain binding 2/1817 10/18639 0.2 2.05162355531095 0.254154719265134 0.583881959220848 GO:0005003 ephrin receptor activity 7/1817 53/18639 0.132075471698113 1.35484574407327 0.255611578963911 0.583911196390252 GO:0005005 transmembrane-ephrin receptor activity 7/1817 53/18639 0.132075471698113 1.35484574407327 0.255611578963911 0.583911196390252 GO:0038064 collagen receptor activity 7/1817 53/18639 0.132075471698113 1.35484574407327 0.255611578963911 0.583911196390252 GO:1901981 phosphatidylinositol phosphate binding 21/1817 185/18639 0.113513513513514 1.16443499085216 0.262859663184172 0.599339795944362 GO:0008266 poly(U) RNA binding 4/1817 27/18639 0.148148148148148 1.51972115208219 0.266462381704392 0.604147418705471 GO:0008320 protein transmembrane transporter activity 4/1817 27/18639 0.148148148148148 1.51972115208219 0.266462381704392 0.604147418705471 GO:0023026 MHC class II protein complex binding 4/1817 27/18639 0.148148148148148 1.51972115208219 0.266462381704392 0.604147418705471 GO:0051287 NAD binding 7/1817 54/18639 0.12962962962963 1.32975600807191 0.271108725778331 0.609092908759069 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/1817 36/18639 0.138888888888889 1.42473858007705 0.271154303981779 0.609092908759069 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/1817 36/18639 0.138888888888889 1.42473858007705 0.271154303981779 0.609092908759069 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/1817 36/18639 0.138888888888889 1.42473858007705 0.271154303981779 0.609092908759069 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/1817 36/18639 0.138888888888889 1.42473858007705 0.271154303981779 0.609092908759069 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1817 19/18639 0.157894736842105 1.61970280682444 0.281006686255664 0.62428774803685 GO:0008301 DNA binding, bending 3/1817 19/18639 0.157894736842105 1.61970280682444 0.281006686255664 0.62428774803685 GO:0008381 mechanosensitive monoatomic ion channel activity 3/1817 19/18639 0.157894736842105 1.61970280682444 0.281006686255664 0.62428774803685 GO:0042577 lipid phosphatase activity 3/1817 19/18639 0.157894736842105 1.61970280682444 0.281006686255664 0.62428774803685 GO:0042834 peptidoglycan binding 3/1817 19/18639 0.157894736842105 1.61970280682444 0.281006686255664 0.62428774803685 GO:0050145 nucleoside monophosphate kinase activity 3/1817 19/18639 0.157894736842105 1.61970280682444 0.281006686255664 0.62428774803685 GO:0043178 alcohol binding 11/1817 92/18639 0.119565217391304 1.22651408197937 0.283424741443997 0.624509475003364 GO:0016798 hydrolase activity, acting on glycosyl bonds 15/1817 130/18639 0.115384615384615 1.18362897421786 0.284428463318377 0.624509475003364 GO:0051119 sugar transmembrane transporter activity 4/1817 28/18639 0.142857142857143 1.46544539665068 0.289006000535742 0.624509475003364 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/1817 28/18639 0.142857142857143 1.46544539665068 0.289006000535742 0.624509475003364 GO:0003697 single-stranded DNA binding 14/1817 121/18639 0.115702479338843 1.18688966009725 0.289967607271383 0.624509475003364 GO:0022829 wide pore channel activity 5/1817 37/18639 0.135135135135135 1.38623213196686 0.290639157401347 0.624509475003364 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0002162 dystroglycan binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0003953 NAD+ nucleosidase activity 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0005114 type II transforming growth factor beta receptor binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0008271 secondary active sulfate transmembrane transporter activity 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0015217 ADP transmembrane transporter activity 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0032794 GTPase activating protein binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0034511 U3 snoRNA binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0034713 type I transforming growth factor beta receptor binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0043522 leucine zipper domain binding 2/1817 11/18639 0.181818181818182 1.86511232300996 0.291918278917483 0.624509475003364 GO:0003684 damaged DNA binding 9/1817 74/18639 0.121621621621622 1.24760891877017 0.293268742117642 0.625193293828998 GO:0048029 monosaccharide binding 9/1817 74/18639 0.121621621621622 1.24760891877017 0.293268742117642 0.625193293828998 GO:0043495 protein-membrane adaptor activity 6/1817 47/18639 0.127659574468085 1.30954695019848 0.307019194485064 0.653358391070847 GO:0015095 magnesium ion transmembrane transporter activity 3/1817 20/18639 0.15 1.53871766648321 0.308722482965224 0.653543406346975 GO:0016004 phospholipase activator activity 3/1817 20/18639 0.15 1.53871766648321 0.308722482965224 0.653543406346975 GO:0016408 C-acyltransferase activity 3/1817 20/18639 0.15 1.53871766648321 0.308722482965224 0.653543406346975 GO:0005109 frizzled binding 5/1817 38/18639 0.131578947368421 1.34975233902036 0.31035775313696 0.65547245489234 GO:0003785 actin monomer binding 4/1817 29/18639 0.137931034482759 1.41491279676617 0.311795223802869 0.65547245489234 GO:0016417 S-acyltransferase activity 4/1817 29/18639 0.137931034482759 1.41491279676617 0.311795223802869 0.65547245489234 GO:0106222 lncRNA binding 4/1817 29/18639 0.137931034482759 1.41491279676617 0.311795223802869 0.65547245489234 GO:0004601 peroxidase activity 7/1817 57/18639 0.12280701754386 1.25976884975234 0.318904908799994 0.663232510871744 GO:0015932 nucleobase-containing compound transmembrane transporter activity 7/1817 57/18639 0.12280701754386 1.25976884975234 0.318904908799994 0.663232510871744 GO:0051536 iron-sulfur cluster binding 9/1817 76/18639 0.118421052631579 1.21477710511833 0.320972161865818 0.663232510871744 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/1817 48/18639 0.125 1.28226472206935 0.324760365934012 0.663232510871744 GO:0051087 protein-folding chaperone binding 15/1817 134/18639 0.111940298507463 1.14829676603225 0.325747532879209 0.663232510871744 GO:0003995 acyl-CoA dehydrogenase activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0004859 phospholipase inhibitor activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0005165 neurotrophin receptor binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0005247 voltage-gated chloride channel activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0005527 macrolide binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0008179 adenylate cyclase binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0015368 calcium:monoatomic cation antiporter activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0016273 arginine N-methyltransferase activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0016274 protein-arginine N-methyltransferase activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0016423 tRNA (guanine) methyltransferase activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0016801 hydrolase activity, acting on ether bonds 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0016803 ether hydrolase activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0035259 nuclear glucocorticoid receptor binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0043047 single-stranded telomeric DNA binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0045295 gamma-catenin binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0070008 serine-type exopeptidase activity 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0097371 MDM2/MDM4 family protein binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:1990459 transferrin receptor binding 2/1817 12/18639 0.166666666666667 1.70968629609246 0.329410795627728 0.663232510871744 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/1817 39/18639 0.128205128205128 1.31514330468651 0.330249329403572 0.663232510871744 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/1817 39/18639 0.128205128205128 1.31514330468651 0.330249329403572 0.663232510871744 GO:0001965 G-protein alpha-subunit binding 4/1817 30/18639 0.133333333333333 1.36774903687397 0.334737659452272 0.670027691279877 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/1817 30/18639 0.133333333333333 1.36774903687397 0.334737659452272 0.670027691279877 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/1817 21/18639 0.142857142857143 1.46544539665068 0.336517504997924 0.670272140496686 GO:0005248 voltage-gated sodium channel activity 3/1817 21/18639 0.142857142857143 1.46544539665068 0.336517504997924 0.670272140496686 GO:0035613 RNA stem-loop binding 3/1817 21/18639 0.142857142857143 1.46544539665068 0.336517504997924 0.670272140496686 GO:0035254 glutamate receptor binding 6/1817 49/18639 0.122448979591837 1.25609605427201 0.342635293076603 0.681338705740852 GO:0140789 histone phosphatase activity 15/1817 136/18639 0.110294117647059 1.13141004888472 0.346939075142162 0.688767754742132 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1817 40/18639 0.125 1.28226472206935 0.350254938485279 0.691953160232318 GO:0061791 GTPase motor activity 5/1817 40/18639 0.125 1.28226472206935 0.350254938485279 0.691953160232318 GO:1990606 membrane scission GTPase motor activity 5/1817 40/18639 0.125 1.28226472206935 0.350254938485279 0.691953160232318 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1817 59/18639 0.11864406779661 1.21706482094718 0.351531222551469 0.693345321877938 GO:0008327 methyl-CpG binding 4/1817 31/18639 0.129032258064516 1.32362810020061 0.357745711062148 0.703315312023316 GO:0070273 phosphatidylinositol-4-phosphate binding 4/1817 31/18639 0.129032258064516 1.32362810020061 0.357745711062148 0.703315312023316 GO:0016874 ligase activity 18/1817 167/18639 0.107784431137725 1.10566538908973 0.362946079891389 0.70420584138873 GO:0016835 carbon-oxygen lyase activity 9/1817 79/18639 0.113924050632911 1.16864632897459 0.363393857988418 0.70420584138873 GO:0033293 monocarboxylic acid binding 9/1817 79/18639 0.113924050632911 1.16864632897459 0.363393857988418 0.70420584138873 GO:0061133 endopeptidase activator activity 3/1817 22/18639 0.136363636363636 1.39883424225747 0.364245110300623 0.70420584138873 GO:0004535 poly(A)-specific ribonuclease activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0008253 5'-nucleotidase activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0019104 DNA N-glycosylase activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0030955 potassium ion binding 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0071837 HMG box domain binding 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0140852 histone ubiquitin ligase activity 2/1817 13/18639 0.153846153846154 1.57817196562381 0.366326369263222 0.70420584138873 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 10/1817 89/18639 0.112359550561798 1.15259750298368 0.367503578213841 0.704236714649903 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 10/1817 89/18639 0.112359550561798 1.15259750298368 0.367503578213841 0.704236714649903 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/1817 41/18639 0.121951219512195 1.25098997275058 0.370317794890618 0.706282209437609 GO:0042287 MHC protein binding 5/1817 41/18639 0.121951219512195 1.25098997275058 0.370317794890618 0.706282209437609 GO:0140318 protein transporter activity 5/1817 41/18639 0.121951219512195 1.25098997275058 0.370317794890618 0.706282209437609 GO:0035591 signaling adaptor activity 14/1817 129/18639 0.108527131782946 1.11328409978114 0.377638736305714 0.719114265524068 GO:0015106 bicarbonate transmembrane transporter activity 4/1817 32/18639 0.125 1.28226472206935 0.38073702629988 0.720969346975557 GO:0042910 xenobiotic transmembrane transporter activity 4/1817 32/18639 0.125 1.28226472206935 0.38073702629988 0.720969346975557 GO:0051059 NF-kappaB binding 4/1817 32/18639 0.125 1.28226472206935 0.38073702629988 0.720969346975557 GO:0140793 histone H2AXY142 phosphatase activity 10/1817 90/18639 0.111111111111111 1.13979086406164 0.380990396876613 0.720969346975557 GO:0015026 coreceptor activity 7/1817 61/18639 0.114754098360656 1.17716105632596 0.38447003410823 0.725291059678512 GO:0019905 syntaxin binding 7/1817 61/18639 0.114754098360656 1.17716105632596 0.38447003410823 0.725291059678512 GO:0004222 metalloendopeptidase activity 12/1817 110/18639 0.109090909090909 1.11906739380597 0.385751226026529 0.726578008028229 GO:0016859 cis-trans isomerase activity 5/1817 42/18639 0.119047619047619 1.2212044972089 0.390383566874849 0.72886711778386 GO:0031492 nucleosomal DNA binding 5/1817 42/18639 0.119047619047619 1.2212044972089 0.390383566874849 0.72886711778386 GO:0099106 ion channel regulator activity 17/1817 160/18639 0.10625 1.08992501375894 0.391756644328568 0.72886711778386 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1817 23/18639 0.130434782608696 1.33801536215932 0.391773586805504 0.72886711778386 GO:0003887 DNA-directed DNA polymerase activity 3/1817 23/18639 0.130434782608696 1.33801536215932 0.391773586805504 0.72886711778386 GO:0005212 structural constituent of eye lens 3/1817 23/18639 0.130434782608696 1.33801536215932 0.391773586805504 0.72886711778386 GO:0005283 amino acid:sodium symporter activity 3/1817 23/18639 0.130434782608696 1.33801536215932 0.391773586805504 0.72886711778386 GO:0008171 O-methyltransferase activity 3/1817 23/18639 0.130434782608696 1.33801536215932 0.391773586805504 0.72886711778386 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/1817 91/18639 0.10989010989011 1.12726568973129 0.394515912960268 0.732845026678108 GO:0005161 platelet-derived growth factor receptor binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0005545 1-phosphatidylinositol binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0008191 metalloendopeptidase inhibitor activity 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0008494 translation activator activity 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0015926 glucosidase activity 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0019992 diacylglycerol binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0032036 myosin heavy chain binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0070742 C2H2 zinc finger domain binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0071933 Arp2/3 complex binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0098847 sequence-specific single stranded DNA binding 2/1817 14/18639 0.142857142857143 1.46544539665068 0.402421255484193 0.732938412766256 GO:0019956 chemokine binding 4/1817 33/18639 0.121212121212121 1.24340821533997 0.403634817341218 0.734046526888902 GO:0003730 mRNA 3'-UTR binding 27/1817 262/18639 0.103053435114504 1.05713427468312 0.410058204337487 0.744119499724793 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1817 43/18639 0.116279069767442 1.19280439262265 0.410400614440137 0.744119499724793 GO:0042578 phosphoric ester hydrolase activity 37/1817 363/18639 0.101928374655647 1.04559327199043 0.412533526741882 0.746870399907318 GO:0004864 protein phosphatase inhibitor activity 6/1817 53/18639 0.113207547169811 1.1612963520628 0.414656289451385 0.748479284381741 GO:1901505 carbohydrate derivative transmembrane transporter activity 6/1817 53/18639 0.113207547169811 1.1612963520628 0.414656289451385 0.748479284381741 GO:1901682 sulfur compound transmembrane transporter activity 7/1817 63/18639 0.111111111111111 1.13979086406164 0.417478082374222 0.751819358946959 GO:0005540 hyaluronic acid binding 3/1817 24/18639 0.125 1.28226472206935 0.418985891713227 0.751819358946959 GO:0060229 lipase activator activity 3/1817 24/18639 0.125 1.28226472206935 0.418985891713227 0.751819358946959 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/1817 24/18639 0.125 1.28226472206935 0.418985891713227 0.751819358946959 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 9/1817 83/18639 0.108433734939759 1.11232602396377 0.420720158667426 0.753816177937353 GO:0015020 glucuronosyltransferase activity 4/1817 34/18639 0.117647058823529 1.20683738547703 0.426368068198625 0.760565392242547 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 4/1817 34/18639 0.117647058823529 1.20683738547703 0.426368068198625 0.760565392242547 GO:0051427 hormone receptor binding 4/1817 34/18639 0.117647058823529 1.20683738547703 0.426368068198625 0.760565392242547 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/1817 54/18639 0.111111111111111 1.13979086406164 0.432599734910517 0.770548426499936 GO:0008252 nucleotidase activity 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0015116 sulfate transmembrane transporter activity 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0015929 hexosaminidase activity 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0031386 protein tag activity 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0033130 acetylcholine receptor binding 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0120283 protein serine/threonine kinase binding 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0141047 molecular tag activity 2/1817 15/18639 0.133333333333333 1.36774903687397 0.437504664976164 0.771356335197801 GO:0004721 phosphoprotein phosphatase activity 18/1817 175/18639 0.102857142857143 1.05512068558849 0.441920613667801 0.778011181972486 GO:0003707 nuclear steroid receptor activity 3/1817 25/18639 0.12 1.23097413318657 0.445779177758477 0.781401940203804 GO:0005537 D-mannose binding 3/1817 25/18639 0.12 1.23097413318657 0.445779177758477 0.781401940203804 GO:0019211 phosphatase activator activity 3/1817 25/18639 0.12 1.23097413318657 0.445779177758477 0.781401940203804 GO:0034061 DNA polymerase activity 4/1817 35/18639 0.114285714285714 1.17235631732054 0.448871643279062 0.785687306345602 GO:0015294 solute:monoatomic cation symporter activity 12/1817 116/18639 0.103448275862069 1.06118459757463 0.459371000964514 0.802906374884661 GO:0031406 carboxylic acid binding 19/1817 187/18639 0.101604278074866 1.0422686510938 0.460334394808307 0.8031538162698 GO:0019212 phosphatase inhibitor activity 6/1817 56/18639 0.107142857142857 1.09908404748801 0.468166350047333 0.8031538162698 GO:0042826 histone deacetylase binding 13/1817 127/18639 0.102362204724409 1.0500435519308 0.469752837597488 0.8031538162698 GO:0004190 aspartic-type endopeptidase activity 4/1817 36/18639 0.111111111111111 1.13979086406164 0.471086310691223 0.8031538162698 GO:0016409 palmitoyltransferase activity 4/1817 36/18639 0.111111111111111 1.13979086406164 0.471086310691223 0.8031538162698 GO:0000062 fatty-acyl-CoA binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0004707 MAP kinase activity 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0004708 MAP kinase kinase activity 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0005024 transforming growth factor beta receptor activity 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0005159 insulin-like growth factor receptor binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0017070 U6 snRNA binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0030275 LRR domain binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0043023 ribosomal large subunit binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0055102 lipase inhibitor activity 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0070411 I-SMAD binding 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0140327 flippase activity 2/1817 16/18639 0.125 1.28226472206935 0.47143076437271 0.8031538162698 GO:0016247 channel regulator activity 17/1817 168/18639 0.101190476190476 1.03802382262757 0.473422268692076 0.805415444492972 GO:0043177 organic acid binding 19/1817 189/18639 0.100529100529101 1.03123935319863 0.479578111102828 0.814745446453404 GO:0016500 protein-hormone receptor activity 7/1817 67/18639 0.104477611940299 1.07174364829677 0.482805536338353 0.819081280529261 GO:0004725 protein tyrosine phosphatase activity 10/1817 98/18639 0.102040816326531 1.04674671189334 0.488934329045376 0.828320308843633 GO:0070001 aspartic-type peptidase activity 4/1817 37/18639 0.108108108108108 1.10898570557349 0.492958692908177 0.833973353553164 GO:0141108 transporter regulator activity 17/1817 170/18639 0.1 1.02581177765548 0.493721759629797 0.834100967174016 GO:0004364 glutathione transferase activity 3/1817 27/18639 0.111111111111111 1.13979086406164 0.497764384840604 0.836475063149213 GO:0005385 zinc ion transmembrane transporter activity 3/1817 27/18639 0.111111111111111 1.13979086406164 0.497764384840604 0.836475063149213 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1817 27/18639 0.111111111111111 1.13979086406164 0.497764384840604 0.836475063149213 GO:0008484 sulfuric ester hydrolase activity 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0016805 dipeptidase activity 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0036041 long-chain fatty acid binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0038191 neuropilin binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0051787 misfolded protein binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0070403 NAD+ binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0070492 oligosaccharide binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:1901567 fatty acid derivative binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:1990226 histone methyltransferase binding 2/1817 17/18639 0.117647058823529 1.20683738547703 0.504091732202865 0.836475063149213 GO:0005501 retinoid binding 4/1817 38/18639 0.105263157894737 1.07980187121629 0.514441156410673 0.850159567746793 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/1817 38/18639 0.105263157894737 1.07980187121629 0.514441156410673 0.850159567746793 GO:0019840 isoprenoid binding 4/1817 38/18639 0.105263157894737 1.07980187121629 0.514441156410673 0.850159567746793 GO:0015459 potassium channel regulator activity 6/1817 59/18639 0.101694915254237 1.04319841795472 0.520257834072302 0.857435805339269 GO:0031593 polyubiquitin modification-dependent protein binding 6/1817 59/18639 0.101694915254237 1.04319841795472 0.520257834072302 0.857435805339269 GO:0046625 sphingolipid binding 3/1817 28/18639 0.107142857142857 1.09908404748801 0.522815390957188 0.858153003019038 GO:0046875 ephrin receptor binding 3/1817 28/18639 0.107142857142857 1.09908404748801 0.522815390957188 0.858153003019038 GO:0051019 mitogen-activated protein kinase binding 3/1817 28/18639 0.107142857142857 1.09908404748801 0.522815390957188 0.858153003019038 GO:0008236 serine-type peptidase activity 19/1817 194/18639 0.0979381443298969 1.0046610193533 0.527184878224129 0.864155753089011 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/1817 18/18639 0.111111111111111 1.13979086406164 0.535411740350029 0.86751490764538 GO:0008308 voltage-gated monoatomic anion channel activity 2/1817 18/18639 0.111111111111111 1.13979086406164 0.535411740350029 0.86751490764538 GO:0015172 acidic amino acid transmembrane transporter activity 2/1817 18/18639 0.111111111111111 1.13979086406164 0.535411740350029 0.86751490764538 GO:0099602 neurotransmitter receptor regulator activity 2/1817 18/18639 0.111111111111111 1.13979086406164 0.535411740350029 0.86751490764538 GO:1901611 phosphatidylglycerol binding 2/1817 18/18639 0.111111111111111 1.13979086406164 0.535411740350029 0.86751490764538 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/1817 39/18639 0.102564102564103 1.05211464374921 0.53549165092577 0.86751490764538 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0140791 histone H2AXS140 phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1817 81/18639 0.0987654320987654 1.01314743472146 0.539246694447334 0.86751490764538 GO:0052689 carboxylic ester hydrolase activity 9/1817 92/18639 0.0978260869565217 1.00351152161949 0.547101278969303 0.873302337463681 GO:0004181 metallocarboxypeptidase activity 3/1817 29/18639 0.103448275862069 1.06118459757463 0.547163871782686 0.873302337463681 GO:0004629 phospholipase C activity 3/1817 29/18639 0.103448275862069 1.06118459757463 0.547163871782686 0.873302337463681 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1817 29/18639 0.103448275862069 1.06118459757463 0.547163871782686 0.873302337463681 GO:0005416 amino acid:monoatomic cation symporter activity 3/1817 29/18639 0.103448275862069 1.06118459757463 0.547163871782686 0.873302337463681 GO:0097472 cyclin-dependent protein kinase activity 3/1817 29/18639 0.103448275862069 1.06118459757463 0.547163871782686 0.873302337463681 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1817 82/18639 0.0975609756097561 1.00079197820046 0.553612163224474 0.881275005237909 GO:0033549 MAP kinase phosphatase activity 8/1817 82/18639 0.0975609756097561 1.00079197820046 0.553612163224474 0.881275005237909 GO:0004532 RNA exonuclease activity 4/1817 40/18639 0.1 1.02581177765548 0.556073507863603 0.882875870469307 GO:0015144 carbohydrate transmembrane transporter activity 4/1817 40/18639 0.1 1.02581177765548 0.556073507863603 0.882875870469307 GO:0030544 Hsp70 protein binding 5/1817 51/18639 0.0980392156862745 1.00569782123086 0.563583471552652 0.888289557984675 GO:0017171 serine hydrolase activity 19/1817 198/18639 0.095959595959596 0.984364837144144 0.564422979136157 0.888289557984675 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1817 19/18639 0.105263157894737 1.07980187121629 0.565341746714072 0.888289557984675 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1817 19/18639 0.105263157894737 1.07980187121629 0.565341746714072 0.888289557984675 GO:0008574 plus-end-directed microtubule motor activity 2/1817 19/18639 0.105263157894737 1.07980187121629 0.565341746714072 0.888289557984675 GO:0031420 alkali metal ion binding 2/1817 19/18639 0.105263157894737 1.07980187121629 0.565341746714072 0.888289557984675 GO:0097001 ceramide binding 2/1817 19/18639 0.105263157894737 1.07980187121629 0.565341746714072 0.888289557984675 GO:0120227 acyl-CoA binding 2/1817 19/18639 0.105263157894737 1.07980187121629 0.565341746714072 0.888289557984675 GO:0030165 PDZ domain binding 8/1817 83/18639 0.0963855421686747 0.98873424352335 0.567787310377226 0.89097801744835 GO:0015179 L-amino acid transmembrane transporter activity 6/1817 62/18639 0.0967741935483871 0.992721075150461 0.570214484303763 0.891042611727209 GO:0031624 ubiquitin conjugating enzyme binding 3/1817 30/18639 0.1 1.02581177765548 0.570766784263843 0.891042611727209 GO:0033612 receptor serine/threonine kinase binding 3/1817 30/18639 0.1 1.02581177765548 0.570766784263843 0.891042611727209 GO:0048019 receptor antagonist activity 3/1817 30/18639 0.1 1.02581177765548 0.570766784263843 0.891042611727209 GO:0005319 lipid transporter activity 17/1817 178/18639 0.0955056179775281 0.979707877536129 0.572962293455725 0.893320388125699 GO:0140098 catalytic activity, acting on RNA 37/1817 387/18639 0.0956072351421189 0.98075027837862 0.57568613455908 0.894953442019579 GO:0001530 lipopolysaccharide binding 4/1817 41/18639 0.0975609756097561 1.00079197820046 0.576155206563385 0.894953442019579 GO:0004521 RNA endonuclease activity 7/1817 73/18639 0.0958904109589041 0.983655129258676 0.576223114771056 0.894953442019579 GO:0017018 myosin phosphatase activity 8/1817 84/18639 0.0952380952380952 0.97696359776712 0.581758864986794 0.902395784180283 GO:0005507 copper ion binding 6/1817 63/18639 0.0952380952380952 0.97696359776712 0.586292000296345 0.908265895733674 GO:0000149 SNARE binding 10/1817 106/18639 0.0943396226415094 0.967746960052336 0.591768538320247 0.908926252469429 GO:0072349 modified amino acid transmembrane transporter activity 3/1817 31/18639 0.0967741935483871 0.992721075150461 0.59359047067831 0.908926252469429 GO:0000339 RNA cap binding 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0001614 purinergic nucleotide receptor activity 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0001972 retinoic acid binding 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0016502 nucleotide receptor activity 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0030742 GTP-dependent protein binding 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0061608 nuclear import signal receptor activity 2/1817 20/18639 0.1 1.02581177765548 0.593854998241721 0.908926252469429 GO:0004520 DNA endonuclease activity 4/1817 42/18639 0.0952380952380952 0.97696359776712 0.595710116004283 0.908926252469429 GO:0019894 kinesin binding 4/1817 42/18639 0.0952380952380952 0.97696359776712 0.595710116004283 0.908926252469429 GO:0051879 Hsp90 protein binding 4/1817 42/18639 0.0952380952380952 0.97696359776712 0.595710116004283 0.908926252469429 GO:0005245 voltage-gated calcium channel activity 4/1817 43/18639 0.0930232558139535 0.954243514098117 0.614716218728812 0.911029734796468 GO:0008200 ion channel inhibitor activity 4/1817 43/18639 0.0930232558139535 0.954243514098117 0.614716218728812 0.911029734796468 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1817 43/18639 0.0930232558139535 0.954243514098117 0.614716218728812 0.911029734796468 GO:0050661 NADP binding 5/1817 54/18639 0.0925925925925926 0.949825720051367 0.615654890146581 0.911029734796468 GO:0120013 lipid transfer activity 6/1817 65/18639 0.0923076923076923 0.946903179374286 0.617482744509062 0.911029734796468 GO:0001846 opsonin binding 2/1817 21/18639 0.0952380952380952 0.97696359776712 0.620943155425279 0.911029734796468 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1817 21/18639 0.0952380952380952 0.97696359776712 0.620943155425279 0.911029734796468 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1817 21/18639 0.0952380952380952 0.97696359776712 0.620943155425279 0.911029734796468 GO:0019200 carbohydrate kinase activity 2/1817 21/18639 0.0952380952380952 0.97696359776712 0.620943155425279 0.911029734796468 GO:0036122 BMP binding 2/1817 21/18639 0.0952380952380952 0.97696359776712 0.620943155425279 0.911029734796468 GO:0072542 protein phosphatase activator activity 2/1817 21/18639 0.0952380952380952 0.97696359776712 0.620943155425279 0.911029734796468 GO:0008514 organic anion transmembrane transporter activity 25/1817 269/18639 0.0929368029739777 0.953356670683528 0.630359547435885 0.911029734796468 GO:0016248 channel inhibitor activity 4/1817 44/18639 0.0909090909090909 0.932556161504978 0.633155822873664 0.911029734796468 GO:0030547 signaling receptor inhibitor activity 4/1817 44/18639 0.0909090909090909 0.932556161504978 0.633155822873664 0.911029734796468 GO:0031072 heat shock protein binding 12/1817 131/18639 0.0916030534351145 0.939674910829444 0.633401165787898 0.911029734796468 GO:0140311 protein sequestering activity 3/1817 33/18639 0.0909090909090909 0.932556161504978 0.636807290027496 0.911029734796468 GO:0003796 lysozyme activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0004090 carbonyl reductase (NADPH) activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0004935 adrenergic receptor activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0004955 prostaglandin receptor activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0005345 purine nucleobase transmembrane transporter activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0008140 cAMP response element binding protein binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0015187 glycine transmembrane transporter activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0015203 polyamine transmembrane transporter activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0019531 oxalate transmembrane transporter activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0031419 cobalamin binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0031996 thioesterase binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0032356 oxidized DNA binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0043295 glutathione binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0043422 protein kinase B binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0050308 sugar-phosphatase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0051864 histone H3K36 demethylase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0051880 G-quadruplex DNA binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0070739 protein-glutamic acid ligase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0070740 tubulin-glutamic acid ligase activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0071723 lipopeptide binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0097177 mitochondrial ribosome binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:1905394 retromer complex binding 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1817 10/18639 0.1 1.02581177765548 0.64154312937726 0.911029734796468 GO:0004540 RNA nuclease activity 11/1817 121/18639 0.0909090909090909 0.932556161504978 0.641669980284112 0.911029734796468 GO:0033691 sialic acid binding 2/1817 22/18639 0.0909090909090909 0.932556161504978 0.646612959937745 0.911029734796468 GO:0034062 5'-3' RNA polymerase activity 2/1817 22/18639 0.0909090909090909 0.932556161504978 0.646612959937745 0.911029734796468 GO:0097747 RNA polymerase activity 2/1817 22/18639 0.0909090909090909 0.932556161504978 0.646612959937745 0.911029734796468 GO:0140784 metal ion sensor activity 2/1817 22/18639 0.0909090909090909 0.932556161504978 0.646612959937745 0.911029734796468 GO:0042605 peptide antigen binding 4/1817 45/18639 0.0888888888888889 0.911832691249312 0.651015267410148 0.911029734796468 GO:0140303 intramembrane lipid transporter activity 4/1817 45/18639 0.0888888888888889 0.911832691249312 0.651015267410148 0.911029734796468 GO:0141110 transporter inhibitor activity 4/1817 45/18639 0.0888888888888889 0.911832691249312 0.651015267410148 0.911029734796468 GO:0004252 serine-type endopeptidase activity 16/1817 176/18639 0.0909090909090909 0.932556161504978 0.653502029292592 0.911029734796468 GO:0008175 tRNA methyltransferase activity 3/1817 34/18639 0.0882352941176471 0.905128039107773 0.657172376010935 0.911029734796468 GO:0019825 oxygen binding 3/1817 34/18639 0.0882352941176471 0.905128039107773 0.657172376010935 0.911029734796468 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/1817 34/18639 0.0882352941176471 0.905128039107773 0.657172376010935 0.911029734796468 GO:0000287 magnesium ion binding 21/1817 230/18639 0.091304347826087 0.936610753511522 0.657394119186319 0.911029734796468 GO:0030145 manganese ion binding 6/1817 68/18639 0.0882352941176471 0.905128039107773 0.661665799233286 0.911029734796468 GO:0004180 carboxypeptidase activity 4/1817 46/18639 0.0869565217391304 0.892010241439544 0.668284624965968 0.911029734796468 GO:0043274 phospholipase binding 2/1817 23/18639 0.0869565217391304 0.892010241439544 0.67088337642653 0.911029734796468 GO:0005126 cytokine receptor binding 25/1817 275/18639 0.0909090909090909 0.932556161504978 0.674219973847172 0.911029734796468 GO:0015297 antiporter activity 12/1817 135/18639 0.0888888888888889 0.911832691249312 0.67472686318586 0.911029734796468 GO:0015293 symporter activity 13/1817 146/18639 0.089041095890411 0.913394048597342 0.675858664870818 0.911029734796468 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0001851 complement component C3b binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0004954 prostanoid receptor activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0008046 axon guidance receptor activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0008199 ferric iron binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0008503 benzodiazepine receptor activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0008526 phosphatidylinositol transfer activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0015205 nucleobase transmembrane transporter activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0019203 carbohydrate phosphatase activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0019215 intermediate filament binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0032050 clathrin heavy chain binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0034056 estrogen response element binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0035252 UDP-xylosyltransferase activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0042285 xylosyltransferase activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0045294 alpha-catenin binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0047676 arachidonate-CoA ligase activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0050998 nitric-oxide synthase binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0070990 snRNP binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0140031 phosphorylation-dependent protein binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0140537 transcription regulator activator activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0180030 inositol phosphate kinase activity 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:1900750 oligopeptide binding 1/1817 11/18639 0.0909090909090909 0.932556161504978 0.676505614423238 0.911029734796468 GO:0000175 3'-5'-RNA exonuclease activity 3/1817 35/18639 0.0857142857142857 0.879267237990408 0.676700569704549 0.911029734796468 GO:0005343 organic acid:sodium symporter activity 3/1817 35/18639 0.0857142857142857 0.879267237990408 0.676700569704549 0.911029734796468 GO:0043015 gamma-tubulin binding 3/1817 35/18639 0.0857142857142857 0.879267237990408 0.676700569704549 0.911029734796468 GO:0061631 ubiquitin conjugating enzyme activity 3/1817 35/18639 0.0857142857142857 0.879267237990408 0.676700569704549 0.911029734796468 GO:0004722 protein serine/threonine phosphatase activity 9/1817 103/18639 0.087378640776699 0.896340388242649 0.684148911471695 0.919650833514117 GO:0140359 ABC-type transporter activity 4/1817 47/18639 0.0851063829787234 0.87303130013232 0.684957405932782 0.919650833514117 GO:0015085 calcium ion transmembrane transporter activity 13/1817 147/18639 0.0884353741496599 0.907180483640897 0.685378692083068 0.919650833514117 GO:0015101 organic cation transmembrane transporter activity 7/1817 81/18639 0.0864197530864197 0.886504005381275 0.686536401389957 0.920186358990075 GO:0070888 E-box binding 5/1817 59/18639 0.0847457627118644 0.869332014962268 0.693754065896734 0.926827046517463 GO:0004806 triacylglycerol lipase activity 2/1817 24/18639 0.0833333333333333 0.85484314804623 0.693783147764103 0.926827046517463 GO:0050699 WW domain binding 2/1817 24/18639 0.0833333333333333 0.85484314804623 0.693783147764103 0.926827046517463 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/1817 36/18639 0.0833333333333333 0.85484314804623 0.695392775069396 0.926935644130964 GO:0045505 dynein intermediate chain binding 3/1817 36/18639 0.0833333333333333 0.85484314804623 0.695392775069396 0.926935644130964 GO:0032266 phosphatidylinositol-3-phosphate binding 4/1817 48/18639 0.0833333333333333 0.85484314804623 0.701030266958764 0.927512313807993 GO:0038187 pattern recognition receptor activity 4/1817 48/18639 0.0833333333333333 0.85484314804623 0.701030266958764 0.927512313807993 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1817 60/18639 0.0833333333333333 0.85484314804623 0.707988261097988 0.927512313807993 GO:0000340 RNA 7-methylguanosine cap binding 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0003720 telomerase activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0004000 adenosine deaminase activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0004126 cytidine deaminase activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0004300 enoyl-CoA hydratase activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0008504 monoamine transmembrane transporter activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0015166 polyol transmembrane transporter activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0031543 peptidyl-proline dioxygenase activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0035197 siRNA binding 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0097677 STAT family protein binding 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1817 12/18639 0.0833333333333333 0.85484314804623 0.708059688859193 0.927512313807993 GO:0019213 deacetylase activity 3/1817 37/18639 0.0810810810810811 0.831739279180116 0.713254605848327 0.933309424912644 GO:0015271 outward rectifier potassium channel activity 2/1817 25/18639 0.08 0.820649422124381 0.715348710373288 0.933531479161985 GO:0017025 TBP-class protein binding 2/1817 25/18639 0.08 0.820649422124381 0.715348710373288 0.933531479161985 GO:0016763 pentosyltransferase activity 4/1817 49/18639 0.0816326530612245 0.837397369514674 0.716502726380716 0.933531479161985 GO:0060590 ATPase regulator activity 4/1817 49/18639 0.0816326530612245 0.837397369514674 0.716502726380716 0.933531479161985 GO:0008083 growth factor activity 14/1817 162/18639 0.0864197530864197 0.886504005381275 0.721472613082241 0.937349996886714 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/1817 61/18639 0.0819672131147541 0.840829325947111 0.721751770067758 0.937349996886714 GO:0016836 hydro-lyase activity 5/1817 61/18639 0.0819672131147541 0.840829325947111 0.721751770067758 0.937349996886714 GO:0004527 exonuclease activity 7/1817 84/18639 0.0833333333333333 0.85484314804623 0.722774025303322 0.937673682024524 GO:0004435 phosphatidylinositol phospholipase C activity 2/1817 26/18639 0.0769230769230769 0.789085982811905 0.735622422715235 0.940442048044239 GO:0008198 ferrous iron binding 2/1817 26/18639 0.0769230769230769 0.789085982811905 0.735622422715235 0.940442048044239 GO:0097602 cullin family protein binding 2/1817 26/18639 0.0769230769230769 0.789085982811905 0.735622422715235 0.940442048044239 GO:0003964 RNA-directed DNA polymerase activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0004465 lipoprotein lipase activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0005172 vascular endothelial growth factor receptor binding 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0009982 pseudouridine synthase activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0019855 calcium channel inhibitor activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0070123 transforming growth factor beta receptor activity, type III 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0089720 caspase binding 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0140333 glycerophospholipid flippase activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0140666 annealing activity 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:1901338 catecholamine binding 1/1817 13/18639 0.0769230769230769 0.789085982811905 0.736537465492191 0.940442048044239 GO:0005272 sodium channel activity 4/1817 51/18639 0.0784313725490196 0.804558256984687 0.745657179481295 0.945469148032403 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 11/1817 132/18639 0.0833333333333333 0.85484314804623 0.750739273931267 0.945469148032403 GO:0044183 protein folding chaperone 6/1817 75/18639 0.08 0.820649422124381 0.751572392975545 0.945469148032403 GO:0015291 secondary active transmembrane transporter activity 25/1817 287/18639 0.0871080139372822 0.893564266250415 0.753002120714061 0.945469148032403 GO:0051082 unfolded protein binding 10/1817 121/18639 0.0826446280991736 0.847778328640889 0.75330438011118 0.945469148032403 GO:0001671 ATPase activator activity 2/1817 27/18639 0.0740740740740741 0.759860576041093 0.754651065745206 0.945469148032403 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1817 27/18639 0.0740740740740741 0.759860576041093 0.754651065745206 0.945469148032403 GO:0035255 ionotropic glutamate receptor binding 2/1817 27/18639 0.0740740740740741 0.759860576041093 0.754651065745206 0.945469148032403 GO:0008081 phosphoric diester hydrolase activity 7/1817 87/18639 0.0804597701149425 0.825365798113601 0.756042189631615 0.945469148032403 GO:0030159 signaling receptor complex adaptor activity 4/1817 52/18639 0.0769230769230769 0.789085982811905 0.759350092698169 0.945469148032403 GO:0015036 disulfide oxidoreductase activity 3/1817 40/18639 0.075 0.769358833241607 0.761971806715449 0.945469148032403 GO:0071949 FAD binding 3/1817 40/18639 0.075 0.769358833241607 0.761971806715449 0.945469148032403 GO:0004065 arylsulfatase activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0004705 JUN kinase activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0005313 L-glutamate transmembrane transporter activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0008174 mRNA methyltransferase activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0008331 high voltage-gated calcium channel activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0008559 ABC-type xenobiotic transporter activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0016530 metallochaperone activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0030983 mismatched DNA binding 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0032454 histone H3K9 demethylase activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0042043 neurexin family protein binding 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0046030 inositol trisphosphate phosphatase activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0061783 peptidoglycan muralytic activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:1901474 azole transmembrane transporter activity 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:1901612 cardiolipin binding 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:1990825 sequence-specific mRNA binding 1/1817 14/18639 0.0714285714285714 0.73272269832534 0.762238712415883 0.945469148032403 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 10/1817 122/18639 0.0819672131147541 0.840829325947111 0.762299115231402 0.945469148032403 GO:0005544 calcium-dependent phospholipid binding 4/1817 53/18639 0.0754716981132075 0.774197568041869 0.772463950164482 0.951779664178029 GO:0016251 RNA polymerase II general transcription initiation factor activity 4/1817 53/18639 0.0754716981132075 0.774197568041869 0.772463950164482 0.951779664178029 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/1817 41/18639 0.0731707317073171 0.750593983650348 0.776641538306401 0.951779664178029 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1817 41/18639 0.0731707317073171 0.750593983650348 0.776641538306401 0.951779664178029 GO:0000774 adenyl-nucleotide exchange factor activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0004089 carbonate dehydratase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0004953 icosanoid receptor activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0008242 omega peptidase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0010181 FMN binding 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0016846 carbon-sulfur lyase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0030553 cGMP binding 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0045504 dynein heavy chain binding 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0047372 monoacylglycerol lipase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0050700 CARD domain binding 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0050780 dopamine receptor binding 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0140776 protein-containing complex destabilizing activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0141050 histone H3K deacetylase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0141051 histone H4K deacetylase activity 1/1817 15/18639 0.0666666666666667 0.683874518436984 0.78543400151872 0.951779664178029 GO:0015370 solute:sodium symporter activity 6/1817 79/18639 0.0759493670886076 0.779097552649729 0.794467648063389 0.959946682964388 GO:0008173 RNA methyltransferase activity 5/1817 67/18639 0.0746268656716418 0.765531177354833 0.794547790351398 0.959946682964388 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/1817 67/18639 0.0746268656716418 0.765531177354833 0.794547790351398 0.959946682964388 GO:0004519 endonuclease activity 10/1817 127/18639 0.078740157480315 0.80772580917754 0.803816633098812 0.961745630109709 GO:0051721 protein phosphatase 2A binding 2/1817 30/18639 0.0666666666666667 0.683874518436984 0.804775588939778 0.961745630109709 GO:0005548 phospholipid transporter activity 5/1817 68/18639 0.0735294117647059 0.754273365923144 0.805093980122677 0.961745630109709 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0005149 interleukin-1 receptor binding 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0008296 3'-5'-DNA exonuclease activity 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0019841 retinol binding 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0022841 potassium ion leak channel activity 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0097027 ubiquitin-protein transferase activator activity 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0140328 floppase activity 1/1817 16/18639 0.0625 0.641132361034673 0.806367550661787 0.961745630109709 GO:0140767 enzyme-substrate adaptor activity 11/1817 139/18639 0.079136690647482 0.81179349310865 0.807136893200069 0.961745630109709 GO:0170055 lipid transmembrane transporter activity 4/1817 56/18639 0.0714285714285714 0.73272269832534 0.808437161586135 0.962349633958765 GO:1990782 protein tyrosine kinase binding 9/1817 117/18639 0.0769230769230769 0.789085982811905 0.816596273172555 0.968123911450353 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1817 31/18639 0.0645161290322581 0.661814050100307 0.819340079854362 0.968123911450353 GO:0005452 solute:inorganic anion antiporter activity 2/1817 31/18639 0.0645161290322581 0.661814050100307 0.819340079854362 0.968123911450353 GO:0016411 acylglycerol O-acyltransferase activity 2/1817 31/18639 0.0645161290322581 0.661814050100307 0.819340079854362 0.968123911450353 GO:0017147 Wnt-protein binding 2/1817 31/18639 0.0645161290322581 0.661814050100307 0.819340079854362 0.968123911450353 GO:0047499 calcium-independent phospholipase A2 activity 2/1817 31/18639 0.0645161290322581 0.661814050100307 0.819340079854362 0.968123911450353 GO:0015081 sodium ion transmembrane transporter activity 13/1817 164/18639 0.0792682926829268 0.813143482287877 0.820678347194862 0.968123911450353 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/1817 70/18639 0.0714285714285714 0.73272269832534 0.824892853671159 0.968123911450353 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0004550 nucleoside diphosphate kinase activity 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0004659 prenyltransferase activity 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0008569 minus-end-directed microtubule motor activity 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0030548 acetylcholine receptor regulator activity 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0070402 NADPH binding 1/1817 17/18639 0.0588235294117647 0.603418692738515 0.82525978931547 0.968123911450353 GO:0008408 3'-5' exonuclease activity 4/1817 58/18639 0.0689655172413793 0.707456398383087 0.829739220908658 0.971218284436893 GO:0005254 chloride channel activity 6/1817 83/18639 0.072289156626506 0.741550682642513 0.831429411807107 0.971218284436893 GO:0031369 translation initiation factor binding 2/1817 32/18639 0.0625 0.641132361034673 0.832922099010615 0.971218284436893 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1817 32/18639 0.0625 0.641132361034673 0.832922099010615 0.971218284436893 GO:0047498 calcium-dependent phospholipase A2 activity 2/1817 32/18639 0.0625 0.641132361034673 0.832922099010615 0.971218284436893 GO:0140142 nucleocytoplasmic carrier activity 2/1817 32/18639 0.0625 0.641132361034673 0.832922099010615 0.971218284436893 GO:0140299 molecular sensor activity 5/1817 71/18639 0.0704225352112676 0.722402660320758 0.834164251269323 0.971218284436893 GO:0000400 four-way junction DNA binding 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0008409 5'-3' exonuclease activity 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0008525 phosphatidylcholine transporter activity 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0015280 ligand-gated sodium channel activity 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0016854 racemase and epimerase activity 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0017128 phospholipid scramblase activity 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0050811 GABA receptor binding 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0070628 proteasome binding 1/1817 18/18639 0.0555555555555556 0.56989543203082 0.842309674548731 0.971218284436893 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/1817 33/18639 0.0606060606060606 0.621704107669986 0.845574667332107 0.973132895136476 GO:0019239 deaminase activity 2/1817 33/18639 0.0606060606060606 0.621704107669986 0.845574667332107 0.973132895136476 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1817 60/18639 0.0666666666666667 0.683874518436984 0.849031963883077 0.9750573534604 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 41/1817 484/18639 0.0847107438016529 0.868972786856911 0.850778295098935 0.9750573534604 GO:0050660 flavin adenine dinucleotide binding 6/1817 86/18639 0.0697674418604651 0.715682635573588 0.855496455894893 0.9750573534604 GO:0015035 protein-disulfide reductase activity 2/1817 34/18639 0.0588235294117647 0.603418692738515 0.85734981053968 0.9750573534604 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1817 34/18639 0.0588235294117647 0.603418692738515 0.85734981053968 0.9750573534604 GO:0016831 carboxy-lyase activity 2/1817 34/18639 0.0588235294117647 0.603418692738515 0.85734981053968 0.9750573534604 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0016918 retinal binding 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0022840 leak channel activity 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0022842 narrow pore channel activity 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0046624 sphingolipid transporter activity 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0141147 intracellularly calcium-gated channel activity 1/1817 19/18639 0.0526315789473684 0.539900935608145 0.857696781650657 0.9750573534604 GO:0016779 nucleotidyltransferase activity 10/1817 136/18639 0.0735294117647059 0.754273365923144 0.864563778350202 0.981943692077523 GO:0004623 phospholipase A2 activity 2/1817 35/18639 0.0571428571428571 0.586178158660272 0.868298249378173 0.984341847192265 GO:0016229 steroid dehydrogenase activity 2/1817 35/18639 0.0571428571428571 0.586178158660272 0.868298249378173 0.984341847192265 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1817 20/18639 0.05 0.512905888827738 0.871583191303759 0.984385857589813 GO:0031418 L-ascorbic acid binding 1/1817 20/18639 0.05 0.512905888827738 0.871583191303759 0.984385857589813 GO:0052745 inositol phosphate phosphatase activity 1/1817 20/18639 0.05 0.512905888827738 0.871583191303759 0.984385857589813 GO:0140664 ATP-dependent DNA damage sensor activity 1/1817 20/18639 0.05 0.512905888827738 0.871583191303759 0.984385857589813 GO:0001216 DNA-binding transcription activator activity 41/1817 491/18639 0.0835030549898167 0.856584172787668 0.873336843442003 0.985448921948976 GO:0004518 nuclease activity 16/1817 209/18639 0.076555023923445 0.785310451793666 0.876017552918298 0.987555103801018 GO:0005484 SNAP receptor activity 2/1817 36/18639 0.0555555555555556 0.56989543203082 0.87846915963163 0.988416340301833 GO:0004536 DNA nuclease activity 4/1817 64/18639 0.0625 0.641132361034673 0.882096944190689 0.988416340301833 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:0008373 sialyltransferase activity 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:0051428 peptide hormone receptor binding 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:0061891 calcium ion sensor activity 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:0070182 DNA polymerase binding 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:1904047 S-adenosyl-L-methionine binding 1/1817 21/18639 0.0476190476190476 0.48848179888356 0.884115193097683 0.988416340301833 GO:0005253 monoatomic anion channel activity 7/1817 103/18639 0.0679611650485437 0.697153635299838 0.88564229578515 0.989012690007586 GO:0046943 carboxylic acid transmembrane transporter activity 14/1817 188/18639 0.074468085106383 0.76390238761578 0.886945810682742 0.989012690007586 GO:0030280 structural constituent of skin epidermis 2/1817 37/18639 0.0540540540540541 0.554492852786744 0.88790999127639 0.989012690007586 GO:0030551 cyclic nucleotide binding 2/1817 37/18639 0.0540540540540541 0.554492852786744 0.88790999127639 0.989012690007586 GO:0015103 inorganic anion transmembrane transporter activity 12/1817 165/18639 0.0727272727272727 0.746044929203983 0.890532515044922 0.990109672379228 GO:0005342 organic acid transmembrane transporter activity 14/1817 189/18639 0.0740740740740741 0.759860576041093 0.891253610771273 0.990109672379228 GO:0004407 histone deacetylase activity 1/1817 22/18639 0.0454545454545455 0.466278080752489 0.895424823248156 0.990109672379228 GO:0005243 gap junction channel activity 1/1817 22/18639 0.0454545454545455 0.466278080752489 0.895424823248156 0.990109672379228 GO:0008649 rRNA methyltransferase activity 1/1817 22/18639 0.0454545454545455 0.466278080752489 0.895424823248156 0.990109672379228 GO:0015377 chloride:monoatomic cation symporter activity 1/1817 22/18639 0.0454545454545455 0.466278080752489 0.895424823248156 0.990109672379228 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1817 22/18639 0.0454545454545455 0.466278080752489 0.895424823248156 0.990109672379228 GO:0033558 protein lysine deacetylase activity 1/1817 22/18639 0.0454545454545455 0.466278080752489 0.895424823248156 0.990109672379228 GO:0000049 tRNA binding 5/1817 80/18639 0.0625 0.641132361034673 0.900704011579949 0.990250144293429 GO:0005246 calcium channel regulator activity 3/1817 53/18639 0.0566037735849057 0.580648176031402 0.900995513096906 0.990250144293429 GO:0016860 intramolecular oxidoreductase activity 3/1817 53/18639 0.0566037735849057 0.580648176031402 0.900995513096906 0.990250144293429 GO:0005262 calcium channel activity 9/1817 131/18639 0.0687022900763359 0.704756183122083 0.901954926772438 0.990250144293429 GO:0016853 isomerase activity 13/1817 180/18639 0.0722222222222222 0.740864061640066 0.903287352197534 0.990250144293429 GO:0031681 G-protein beta-subunit binding 1/1817 23/18639 0.0434782608695652 0.446005120719772 0.905631252649139 0.990250144293429 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1817 23/18639 0.0434782608695652 0.446005120719772 0.905631252649139 0.990250144293429 GO:0071617 lysophospholipid acyltransferase activity 1/1817 23/18639 0.0434782608695652 0.446005120719772 0.905631252649139 0.990250144293429 GO:0140102 catalytic activity, acting on a rRNA 1/1817 23/18639 0.0434782608695652 0.446005120719772 0.905631252649139 0.990250144293429 GO:0030971 receptor tyrosine kinase binding 5/1817 81/18639 0.0617283950617284 0.633217146700911 0.906430061727163 0.990250144293429 GO:0005179 hormone activity 9/1817 132/18639 0.0681818181818182 0.699417121128734 0.906509972214848 0.990250144293429 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 13/1817 181/18639 0.0718232044198895 0.736770890028795 0.907191164724073 0.990250144293429 GO:0003777 microtubule motor activity 4/1817 68/18639 0.0588235294117647 0.603418692738515 0.908673720346291 0.990250144293429 GO:0140223 general transcription initiation factor activity 4/1817 68/18639 0.0588235294117647 0.603418692738515 0.908673720346291 0.990250144293429 GO:0071855 neuropeptide receptor binding 2/1817 40/18639 0.05 0.512905888827738 0.912298163663176 0.990250144293429 GO:0015108 chloride transmembrane transporter activity 8/1817 121/18639 0.0661157024793388 0.678222662912711 0.913208333572266 0.990250144293429 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0004622 lysophospholipase activity 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0005315 phosphate transmembrane transporter activity 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0030552 cAMP binding 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0140612 DNA damage sensor activity 1/1817 24/18639 0.0416666666666667 0.427421574023115 0.914842039818053 0.990250144293429 GO:0008227 G protein-coupled amine receptor activity 2/1817 41/18639 0.0487804878048781 0.500395989100232 0.919254913681472 0.990250144293429 GO:0000030 mannosyltransferase activity 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0001848 complement binding 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0008139 nuclear localization sequence binding 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0008483 transaminase activity 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0017056 structural constituent of nuclear pore 1/1817 25/18639 0.04 0.41032471106219 0.923154261878252 0.990250144293429 GO:0008509 monoatomic anion transmembrane transporter activity 10/1817 149/18639 0.0671140939597315 0.688464280305689 0.924713782514385 0.990250144293429 GO:0003823 antigen binding 12/1817 174/18639 0.0689655172413793 0.707456398383087 0.925568327095868 0.990250144293429 GO:0019842 vitamin binding 10/1817 150/18639 0.0666666666666667 0.683874518436984 0.92820810764922 0.990250144293429 GO:0016829 lyase activity 14/1817 200/18639 0.07 0.718068244358833 0.930381930065096 0.990250144293429 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0004529 DNA exonuclease activity 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0005112 Notch binding 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0005227 calcium-activated cation channel activity 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0019865 immunoglobulin binding 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0051139 metal cation:proton antiporter activity 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0120014 phospholipid transfer activity 1/1817 26/18639 0.0384615384615385 0.394542991405952 0.930655535444773 0.990250144293429 GO:0008375 acetylglucosaminyltransferase activity 2/1817 43/18639 0.0465116279069767 0.477121757049059 0.931638088376424 0.99042681963243 GO:0005104 fibroblast growth factor receptor binding 1/1817 27/18639 0.037037037037037 0.379930288020547 0.937424938125525 0.994835039323064 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1817 27/18639 0.037037037037037 0.379930288020547 0.937424938125525 0.994835039323064 GO:0015171 amino acid transmembrane transporter activity 6/1817 102/18639 0.0588235294117647 0.603418692738515 0.940666129760357 0.996956923601024 GO:0008009 chemokine activity 2/1817 45/18639 0.0444444444444444 0.455916345624656 0.942208264153511 0.996956923601024 GO:0005242 inward rectifier potassium channel activity 1/1817 28/18639 0.0357142857142857 0.36636134916267 0.943533840308306 0.996956923601024 GO:0016866 intramolecular transferase activity 1/1817 28/18639 0.0357142857142857 0.36636134916267 0.943533840308306 0.996956923601024 GO:0051537 2 iron, 2 sulfur cluster binding 1/1817 28/18639 0.0357142857142857 0.36636134916267 0.943533840308306 0.996956923601024 GO:0017022 myosin binding 4/1817 76/18639 0.0526315789473684 0.539900935608145 0.946387756225085 0.999102130810294 GO:0005125 cytokine activity 16/1817 234/18639 0.0683760683760684 0.701409762499471 0.953444829873353 0.999999969948131 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/1817 30/18639 0.0333333333333333 0.341937259218492 0.954021520343684 0.999999969948131 GO:0016769 transferase activity, transferring nitrogenous groups 1/1817 30/18639 0.0333333333333333 0.341937259218492 0.954021520343684 0.999999969948131 GO:0022839 monoatomic ion-gated channel activity 1/1817 30/18639 0.0333333333333333 0.341937259218492 0.954021520343684 0.999999969948131 GO:0070566 adenylyltransferase activity 1/1817 30/18639 0.0333333333333333 0.341937259218492 0.954021520343684 0.999999969948131 GO:0001664 G protein-coupled receptor binding 21/1817 297/18639 0.0707070707070707 0.725321458948316 0.957397732786015 0.999999969948131 GO:0046982 protein heterodimerization activity 27/1817 369/18639 0.0731707317073171 0.750593983650348 0.957973009835005 0.999999969948131 GO:0005184 neuropeptide hormone activity 1/1817 31/18639 0.032258064516129 0.330907025050154 0.958510901693328 0.999999969948131 GO:0160215 deacylase activity 3/1817 65/18639 0.0461538461538462 0.473451589687143 0.959166247799902 0.999999969948131 GO:0099094 ligand-gated monoatomic cation channel activity 8/1817 136/18639 0.0588235294117647 0.603418692738515 0.960890138547869 0.999999969948131 GO:0004620 phospholipase activity 6/1817 109/18639 0.055045871559633 0.564667033571822 0.961055671281616 0.999999969948131 GO:0048020 CCR chemokine receptor binding 2/1817 50/18639 0.04 0.41032471106219 0.962246555115078 0.999999969948131 GO:0043425 bHLH transcription factor binding 1/1817 32/18639 0.03125 0.320566180517336 0.96256215339277 0.999999969948131 GO:0160041 neuropeptide activity 1/1817 32/18639 0.03125 0.320566180517336 0.96256215339277 0.999999969948131 GO:0005048 signal sequence binding 2/1817 51/18639 0.0392156862745098 0.402279128492344 0.965359964572685 0.999999969948131 GO:0016597 amino acid binding 2/1817 51/18639 0.0392156862745098 0.402279128492344 0.965359964572685 0.999999969948131 GO:0016830 carbon-carbon lyase activity 2/1817 51/18639 0.0392156862745098 0.402279128492344 0.965359964572685 0.999999969948131 GO:0042923 neuropeptide binding 1/1817 33/18639 0.0303030303030303 0.310852053834993 0.966218012332166 0.999999969948131 GO:0005525 GTP binding 27/1817 378/18639 0.0714285714285714 0.73272269832534 0.96951217255304 0.999999969948131 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1817 34/18639 0.0294117647058824 0.301709346369258 0.96951704875012 0.999999969948131 GO:0046873 metal ion transmembrane transporter activity 33/1817 450/18639 0.0733333333333333 0.752261970280682 0.970264959194038 0.999999969948131 GO:0016298 lipase activity 7/1817 130/18639 0.0538461538461538 0.552360187968333 0.974814847861788 0.999999969948131 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/1817 130/18639 0.0538461538461538 0.552360187968333 0.974814847861788 0.999999969948131 GO:0004033 aldo-keto reductase (NADPH) activity 1/1817 36/18639 0.0277777777777778 0.28494771601541 0.975180498336186 0.999999969948131 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1817 36/18639 0.0277777777777778 0.28494771601541 0.975180498336186 0.999999969948131 GO:0008374 O-acyltransferase activity 2/1817 55/18639 0.0363636363636364 0.373022464601991 0.975516031573186 0.999999969948131 GO:0042379 chemokine receptor binding 3/1817 72/18639 0.0416666666666667 0.427421574023115 0.976238444917422 0.999999969948131 GO:0019001 guanyl nucleotide binding 28/1817 400/18639 0.07 0.718068244358833 0.978914463450216 0.999999969948131 GO:0032561 guanyl ribonucleotide binding 28/1817 400/18639 0.07 0.718068244358833 0.978914463450216 0.999999969948131 GO:0003924 GTPase activity 22/1817 331/18639 0.0664652567975831 0.681808432278564 0.982240827778493 0.999999969948131 GO:0140662 ATP-dependent protein folding chaperone 1/1817 40/18639 0.025 0.256452944413869 0.983547389208489 0.999999969948131 GO:0046906 tetrapyrrole binding 8/1817 152/18639 0.0526315789473684 0.539900935608145 0.984521983533948 0.999999969948131 GO:0020037 heme binding 7/1817 142/18639 0.0492957746478873 0.50568186222453 0.988058881904358 0.999999969948131 GO:0015276 ligand-gated monoatomic ion channel activity 10/1817 186/18639 0.0537634408602151 0.551511708416923 0.989284353430907 0.999999969948131 GO:0008194 UDP-glycosyltransferase activity 7/1817 145/18639 0.0482758620689655 0.495219478868161 0.990149751265488 0.999999969948131 GO:0022834 ligand-gated channel activity 10/1817 188/18639 0.0531914893617021 0.5456445625827 0.990451498242264 0.999999969948131 GO:0099095 ligand-gated monoatomic anion channel activity 1/1817 47/18639 0.0212765957446809 0.21825782503308 0.991989482458946 0.999999969948131 GO:0016782 transferase activity, transferring sulphur-containing groups 2/1817 70/18639 0.0285714285714286 0.293089079330136 0.993545605970238 0.999999969948131 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/1817 52/18639 0.0192307692307692 0.197271495702976 0.995210200212886 0.999999969948131 GO:0022832 voltage-gated channel activity 8/1817 175/18639 0.0457142857142857 0.468942526928218 0.996354999469041 0.999999969948131 GO:0030170 pyridoxal phosphate binding 1/1817 56/18639 0.0178571428571429 0.183180674581335 0.996826070883949 0.999999969948131 GO:0005216 monoatomic ion channel activity 28/1817 448/18639 0.0625 0.641132361034673 0.997052054918239 0.999999969948131 GO:0070279 vitamin B6 binding 1/1817 57/18639 0.0175438596491228 0.179966978536048 0.997136409860641 0.999999969948131 GO:0016758 hexosyltransferase activity 9/1817 197/18639 0.0456852791878173 0.468644974563415 0.997713978142071 0.999999969948131 GO:0005506 iron ion binding 6/1817 154/18639 0.038961038961039 0.399666926359276 0.998138829755815 0.999999969948131 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/1817 122/18639 0.0327868852459016 0.336331730378845 0.998305360950775 0.999999969948131 GO:0140101 catalytic activity, acting on a tRNA 5/1817 139/18639 0.0359712230215827 0.368997042322114 0.998308374150783 0.999999969948131 GO:0005244 voltage-gated monoatomic ion channel activity 7/1817 173/18639 0.0404624277456647 0.415068349340366 0.9985174826264 0.999999969948131 GO:0004497 monooxygenase activity 3/1817 106/18639 0.0283018867924528 0.290324088015701 0.998562793639701 0.999999969948131 GO:0022843 voltage-gated monoatomic cation channel activity 5/1817 143/18639 0.034965034965035 0.358675446732684 0.998755029457638 0.999999969948131 GO:0016757 glycosyltransferase activity 13/1817 267/18639 0.048689138576779 0.499458917959595 0.998906388553 0.999999969948131 GO:0005261 monoatomic cation channel activity 18/1817 341/18639 0.0527859237536657 0.541484222809342 0.999128516254393 0.999999969948131 GO:0022836 gated channel activity 16/1817 318/18639 0.050314465408805 0.516131712027913 0.999334924132912 0.999999969948131 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1817 73/18639 0.0136986301369863 0.140522161322668 0.99944845068858 0.999999969948131 GO:0005249 voltage-gated potassium channel activity 2/1817 98/18639 0.0204081632653061 0.209349342378669 0.999511585536347 0.999999969948131 GO:0019003 GDP binding 1/1817 75/18639 0.0133333333333333 0.136774903687397 0.999551127621436 0.999999969948131 GO:0015079 potassium ion transmembrane transporter activity 5/1817 160/18639 0.03125 0.320566180517336 0.999671573557695 0.999999969948131 GO:0005267 potassium channel activity 3/1817 124/18639 0.0241935483870968 0.248180268787615 0.999699954212814 0.999999969948131 GO:0030594 neurotransmitter receptor activity 1/1817 97/18639 0.0103092783505155 0.105753791510874 0.999953508216575 0.999999969948131 GO:0030527 structural constituent of chromatin 1/1817 98/18639 0.0102040816326531 0.104674671189334 0.999958064120495 0.999999969948131 GO:0045182 translation regulator activity 15/1817 356/18639 0.0421348314606742 0.43222406361888 0.999973997012221 0.999999969948131 GO:0008528 G protein-coupled peptide receptor activity 1/1817 122/18639 0.00819672131147541 0.0840829325947112 0.999996477501117 0.999999969948131 GO:0001653 peptide receptor activity 1/1817 128/18639 0.0078125 0.0801415451293341 0.99999810465774 0.999999969948131 GO:0030371 translation repressor activity 8/1817 329/18639 0.0243161094224924 0.24943751432352 0.999999969948131 0.999999969948131