category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	82/492	238/9376	6.56582633053221	RPL13A/RPS14/RPS8/RPS11/RPL28/RPL27A/C1QA/RPS15/RPLP2/RPS20/F13A1/RPL18A/RPS9/RPS28/RPS26/RPL23/RPL7/RPL10/C1QB/RPL37A/RPS2/RPS16/UBA52/RPLP1/RPL8/RPS5/RPS4X/CFD/RPL18/RPL31/RPS12/RPL29/C5AR1/RPS3/RPS27A/RPL21/RPL36/RPL15/RPL19/RPL35/RPL13/CYBB/RPS24/RPS27/RPS19/RPL37/RPL5/RPL6/RPL11/RPL34/RPL3/FCGR2A/RPS6/RPS18/C1QC/RPS29/RPL22/RPL39/RPSA/HBEGF/C3AR1/RPL4/SYK/RPS3A/RPL38/TLR7/RPL32/RPL10A/RPL35A/RPS23/RPL9/TLR4/RPL14/RPLP0/RPS15A/PIK3R1/NLRP3/RPL30/NRP1/PRKCB/IL6R/CCL2	20.4671073437057
Genetic Information Processing	Translation	hsa03010	Ribosome	65/492	222/9376	5.57972606753095	RPL13A/RPS14/RPS8/RPS11/RPL28/RPL27A/RPS15/RPLP2/RPS20/RPL18A/RPS9/RPS28/RPS26/RPL23/RPL7/RPL10/RPL37A/RPS2/RPS16/UBA52/RPLP1/RPL8/RPS5/RPS4X/RPL18/RPL31/RPS12/RPL29/RPS3/RPS27A/RPL21/RPL36/RPL15/RPL19/RPL35/RPL13/RPS24/RPS27/RPS19/RPL37/RPL5/RPL6/RPL11/RPL34/RACK1/RPL3/RPS6/RPS18/RPS29/RPL22/RPL39/RPSA/RPL4/RPS3A/RPL38/RPL32/RPL10A/RPL35A/RPS23/RPL9/RPL14/RPLP0/RPS15A/RPL30/MRPS21	16.2507889317313
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/492	205/9376	4.1832242712671	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/CYBA/CTSD/ATP5F1E/COL1A1/COX4I1/MT-ND6/CYBB/SLC25A6/MT-ATP8/UQCRB/CD36/COL1A2/NCF1/MT-ND4L/ATP5F1D/COL3A1/NCF4/NDUFS6/COX6B1/COX4I2/MMP2/NCF2/RAC2/NDUFB10/RAC1/UQCRQ/NDUFS7/PIK3R1/PLCB2/UQCR10/PRKCB/NDUFB11/PPP1CA/NDUFB7/NDUFA3	10.8442553652646
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/492	155/9376	4.42612116443745	CD14/HLA-DRA/CYBA/CTSS/MRC1/HLA-DRB5/CYBB/HLA-DRB1/ITGB2/HLA-DPA1/HLA-DPB1/CD36/NCF1/CORO1A/FCGR2A/HLA-A/HLA-DMB/FCGR1A/CD209/NCF4/COLEC12/ATP6V0D1/HLA-DMA/HLA-DQB1/HLA-E/ATP6V0B/HLA-DQA1/NCF2/ITGAM/TLR4/RAC1/FCGR3A/TUBA1B/CLEC7A/ATP6V1F/MSR1	10.1214671614298
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	32/492	138/9376	4.41899375515494	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/ATP5F1E/COX4I1/MT-ND6/ATP5ME/MT-ATP8/UQCRB/MT-ND4L/ATP5F1D/ATP6V0D1/NDUFS6/COX6B1/ATP6V0B/COX4I2/NDUFB10/UQCRQ/NDUFS7/ATP5MF/ATP6V1F/UQCR10/NDUFB11/NDUFB7/NDUFA3	9.52166256165475
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	24/492	78/9376	5.86366479049406	HLA-DRA/CYBA/HLA-DRB5/CYBB/HLA-DRB1/ITGB2/HLA-DPA1/HLA-DPB1/NCF1/FCGR2A/PTPN6/HLA-DMB/FCGR1A/NCF4/HLA-DMA/HLA-DQB1/CR1/HLA-DQA1/NCF2/ITGAM/TLR4/FCGR3A/ITGA4/PRKCB	10.1503280913754
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	27/492	100/9376	5.14536585365854	CD14/HLA-DRA/CSF1R/HLA-DRB5/HLA-DRB1/CD37/HLA-DPA1/HLA-DPB1/CD36/CD4/HLA-DMB/FCGR1A/HLA-DMA/HLA-DQB1/CSF2RA/CR1/HLA-DQA1/CSF3R/ITGAM/CD44/ITGA4/FLT3LG/CD3E/CD34/CD33/IL6R/CD7	9.80723112524134
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/492	275/9376	3.04910569105691	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/C1QA/C1QB/CYBA/ATP5F1E/COX4I1/MT-ND6/CYBB/SLC25A6/MT-ATP8/UQCRB/NCF1/MT-ND4L/CCL5/C1QC/ATP5F1D/NCF4/NDUFS6/COX6B1/COX4I2/LAMC1/NCF2/RAC2/NDUFB10/RAC1/UQCRQ/NDUFS7/TUBA1B/PIK3R1/UQCR10/NDUFB11/RYR1/NDUFB7/NDUFA3/PSMA7	8.11614998052712
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	39/492	227/9376	3.27409476737939	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/HGF/CYBA/ATP5F1E/COX4I1/MT-ND6/SLC25A6/MT-ATP8/UQCRB/NCF1/MT-ND4L/ATP5F1D/HMOX1/NDUFS6/COX6B1/COX4I2/NCF2/CYP1B1/NDUFB10/RAC1/UQCRQ/NDUFS7/PIK3R1/SLC26A2/UQCR10/NDUFB11/NDUFB7/GRB2/NDUFA3/NRAS	8.16203754810172
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/492	99/9376	4.61985710766199	C1QA/C1QB/HLA-DRA/CFD/C5AR1/HLA-DRB5/HLA-DRB1/ITGB2/HLA-DPA1/HLA-DPB1/FCGR2A/C1QC/FPR1/HLA-DMB/FCGR1A/C3AR1/HLA-DMA/ITGAL/SELPLG/HLA-DQB1/HLA-DQA1/PTAFR/ITGAM/FCGR3A	8.52058004937181
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	23/492	95/9376	4.6137783483098	HLA-DRA/CCL3/HLA-DRB5/HLA-DRB1/ITGB2/HLA-DPA1/HLA-DPB1/CCL5/HLA-DMB/ATP6V0D1/HLA-DMA/ITGAL/ACP5/HLA-DQB1/LTB/ATP6V0B/HLA-DQA1/CD28/TLR4/TNFRSF11A/CD86/ATP6V1F/CCL2	8.33086011997169
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/492	181/9376	3.36917755917891	CD74/CD14/FCER1G/HLA-DRA/CTSD/CTSS/MRC1/HLA-DRB5/HLA-DRB1/ITGB2/HLA-DPA1/HLA-DPB1/CORO1A/FCGR2A/HLA-DMB/FCGR1A/CD209/ATP6V0D1/HLA-DMA/SYK/HLA-DQB1/ATP6V0B/CR1/HLA-DQA1/LSP1/ITGAM/IL10RA/CALM1/TLR4/ITGAX/FCGR3A/CLEC7A	7.57399380651601
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/492	70/9376	5.1725900116144	HLA-DRA/HLA-DRB5/HLA-DRB1/ITGB2/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DMB/HLA-DMA/ITGAL/HLA-DQB1/HLA-E/CCND1/HLA-DQA1/CD28/RAC2/RAC1/LAMA2/CD86	8.24588217047403
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	25/492	133/9376	3.58212604682438	TYROBP/FCER1G/HCST/ITGB2/PTPN6/HLA-A/ITGAL/SYK/HLA-E/LCP2/RAC2/VAV1/RAC1/TNFSF10/FCGR3A/LAT2/PIK3R1/CD247/PRKCB/PTK2B/VAV3/CD48/PAK1/GRB2/NRAS	7.05765942535804
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/492	82/9376	4.41562561967083	CD74/HLA-DRA/CTSS/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSB/CD4/LGMN/HLA-A/HLA-DMB/HLA-DMA/IFI30/HLA-DQB1/HLA-E/HLA-DQA1/HSP90AB1/PSME1	7.31037691340017
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/492	39/9376	6.35230352303523	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/CD28/CD86	7.88194268626937
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	33/492	235/9376	2.67607680332122	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/ATP5F1E/COX4I1/MT-ND6/ATP5ME/MT-ATP8/UQCRB/RPS6/MT-ND4L/ATP5F1D/NDUFS6/COX6B1/COX4I2/NDUFB10/UQCRQ/NDUFS7/ATP5MF/UQCR10/NDUFB11/NDUFB7/GRB2/NDUFA3/NRAS/RPS6KA1	6.12343210487525
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/492	44/9376	5.63045084996305	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/CD28/CD86	7.24479609186277
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	29/492	193/9376	2.86347360882935	CXCL14/CCL4/CCL3/NCF1/CCL5/CXCR4/WAS/ARRB2/CCR1/GNG2/DOCK2/CCL4L2/HCK/RAC2/VAV1/RAC1/FGR/PIK3R1/PREX1/PLCB2/PRKCB/GNAI2/PTK2B/CXCL16/VAV3/PAK1/GRB2/NRAS/CCL2	6.15564439977104
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/492	45/9376	5.50532971996387	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/CD28/CD86	7.12906635314922
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/492	142/9376	3.22088629336998	TYROBP/CSF1R/CYBA/SPI1/NCF1/FCGR2A/FCGR1A/LILRB5/LILRB3/NCF4/SYK/ACP5/LILRB2/LILRB1/NCF2/LCP2/LILRB4/RAC1/FCGR3A/TNFRSF11A/PIK3R1/TREM2/BTK/GRB2	6.27537199847248
Human Diseases	Immune disease	hsa05310	Asthma	11/492	32/9376	6.55081300813008	FCER1G/HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-DQA1/PRG2	7.40165922747433
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/492	54/9376	4.94068051791629	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-A/CGA/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/CD28/CD86	6.8340393021718
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	35/492	268/9376	2.488775634025	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/UBA52/ATP5F1E/COX4I1/MT-ND6/RPS27A/SLC25A6/MT-ATP8/UQCRB/MT-ND4L/UBB/ATP5F1D/NDUFS6/COX6B1/COX4I2/CALM1/NDUFB10/UQCRQ/NDUFS7/TUBA1B/UQCR10/GNAI2/NDUFB11/NDUFB7/NDUFA3/PSMA7	5.81900932306484
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	21/492	116/9376	3.44995794785534	CYBA/CYBB/ITGB2/PECAM1/NCF1/MYL9/CXCR4/NCF4/ITGAL/MMP2/NCF2/ITGAM/RAC2/VAV1/RAC1/PIK3R1/ITGA4/PRKCB/GNAI2/PTK2B/VAV3	6.24807229366849
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/492	98/9376	3.69470715115314	PTPRC/CFL1/NCF1/FCGR2A/FCGR1A/ARPC2/WAS/SYK/INPP5D/HCK/RAC2/VAV1/RAC1/SCIN/FCGR3A/PIK3R1/PRKCB/VAV3/PAK1	6.31046472322198
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	25/492	160/9376	2.97764227642276	HLA-DRA/HLA-DRB5/PTPRC/HLA-DRB1/ITGB2/PECAM1/HLA-DPA1/HLA-DPB1/CD4/HLA-A/SIGLEC1/HLA-DMB/HLA-DMA/ITGAL/SELPLG/HLA-DQB1/HLA-E/HLA-DQA1/CD28/ITGAM/CD86/CADM3/JAML/ITGA4/CD34	5.93745608427678
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	13/492	50/9376	4.95479674796748	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/CXCR4/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-DQA1/CD28/CD86/ITGA4	6.59819854421168
NA	NA	hsa04518	Integrin signaling	24/492	154/9376	2.96990814063985	SPP1/HGF/COL1A1/COL6A2/ITGB2/COL1A2/TNXB/TLN1/ITGAL/LAMB1/FLNA/CCND1/LAMA4/LAMC1/ITGAM/PARVG/RAC2/RAC1/LAMA2/ITGAX/IGF1/COL6A1/PIK3R1/ITGA4	5.80039662321741
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	27/492	195/9376	2.63864915572233	CYBA/C5AR1/CYBB/ITGB2/SLC25A6/NCF1/FCGR2A/FPR1/FCGR1A/NCF4/ITGAL/SYK/SELPLG/TLR7/CR1/NCF2/ITGAM/RAC2/TLR4/RAC1/FCGR3A/CLEC7A/PIK3R1/PLCB2/PRKCB/HDAC5/HMGB1	5.44154475162396
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/492	91/9376	3.56008219422854	PTPN6/LILRB5/LILRB3/SYK/LILRB2/LILRB1/INPP5D/RAC2/LILRB4/VAV1/RAC1/PIK3R1/BTK/PRKCB/VAV3/GRB2/NRAS	5.77494118892397
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	36/492	308/9376	2.22743110547989	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/ATP5F1E/COX4I1/MT-ND6/GPX3/SLC25A6/MT-ATP8/UQCRB/AP2S1/MT-ND4L/CLTC/ATP5F1D/NDUFS6/COX6B1/COX4I2/NDUFB10/UQCRQ/NDUFS7/TUBA1B/PLCB2/UQCR10/NDUFB11/NDUFB7/AP2M1/POLR2D/NDUFA3/PSMA7	5.15442995343187
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	27/492	203/9376	2.5346629820978	SPP1/HGF/COL1A1/COL6A2/COL1A2/MYL9/TNXB/TLN1/LAMB1/FLNA/CCND1/LAMA4/LAMC1/PARVG/RAC2/VAV1/RAC1/LAMA2/IGF1/COL6A1/PIK3R1/ITGA4/PRKCB/PPP1CA/VAV3/PAK1/GRB2	5.20198690239274
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/492	50/9376	4.57365853658537	HBB/HBA2/HGF/HBA1/ITGB2/PECAM1/CD36/ITGAL/GYPC/CR1/TLR4/CCL2	5.96230604410346
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/492	69/9376	3.86661953576058	FCER1G/ALOX5AP/SYK/INPP5D/LCP2/RAC2/VAV1/RAC1/PIK3R1/BTK/VAV3/GRB2/NRAS/ALOX5	5.62410809599564
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/492	88/9376	3.46489283074649	C1QA/F13A1/C1QB/CFD/C5AR1/ITGB2/VSIG4/A2M/SERPINA1/C1QC/C3AR1/CR1/ITGAM/ITGAX/CLU/C4BPB	5.46691333219719
NA	NA	hsa04517	IgSF CAM signaling	34/492	299/9376	2.16700655300867	ITGB2/CD84/LMO7/MYL9/NRP2/PTPN6/ARPC2/CD209/ITGAL/DOK2/EPB41L3/INPP5D/MTSS1/CD28/ITGAM/LCP2/VAV1/RAC1/ITGAX/MYL6/TUBA1B/CD86/PIK3R1/SLIT3/CADM3/JAML/ITGA4/NRP1/PRKCB/MYH10/VAV3/CD48/PAK1/GRB2	4.82615911070972
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/492	138/9376	2.76187109697184	FYB1/CD4/FCGR2A/ARPC2/WAS/PYCARD/SKAP2/LCP2/RAC2/VAV1/TLR4/RAC1/PIK3R1/NLRP3/RHOG/ITGA4/PTK2B/VAV3/CCL2/RPS6KA1	4.90668988125662
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	29/492	250/9376	2.21060162601626	CTSD/LAPTM5/PSAP/CTSS/CTSC/CTSZ/CD68/CTSB/AP2S1/SLC11A1/LGMN/CLTC/ATP6V0D1/VAMP8/NPC2/ACP5/TPP1/LAMTOR4/ATP6V0B/TLR7/AP1B1/CTSW/ASAH1/GM2A/SORT1/ATP6V1F/MCOLN1/RRAGB/AP2M1	4.56556930433713
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/492	112/9376	2.89256678281069	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DMB/HLA-DMA/LAMB1/HLA-DQB1/HLA-DQA1/LAMA4/LAMC1/IL10RA/TLR4/LAMA2/GNAI2/ALOX5	4.74159947490507
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/492	93/9376	3.07369525308156	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/CD4/HLA-DMB/RBPJ/HLA-DMA/HLA-DQB1/HLA-DQA1/IL2RG/RUNX3/CD247/CD3E	4.72940109100131
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/492	78/9376	3.17615176151761	C1QA/CD14/C1QB/ITGB2/CFL1/C1QC/PYCARD/ITGAM/CALM1/TLR4/NLRP3/C4BPB/GNAI2	4.54156593998835
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	36/492	368/9376	1.86426299045599	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/ATP5F1E/COX4I1/MT-ND6/TNFRSF1B/GPX3/MT-ATP8/UQCRB/MT-ND4L/ATP5F1D/PFN1/NDUFS6/COX6B1/COX4I2/NDUFB10/RAC1/UQCRQ/NDUFS7/TUBA1B/NUP93/UQCR10/CHCHD10/NDUFB11/NDUFB7/TPR/NDUFA3/PSMA7	3.98033431956969
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/492	103/9376	2.77527823821928	CD14/COL1A1/ITGB2/COL1A2/COL3A1/LAMB1/LAMA4/LAMC1/ITGAM/TLR4/LAMA2/PIK3R1/PLCB2/PRKCB/GNA15	4.26323062029537
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	37/492	388/9376	1.81728270890956	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/APOE/ATP5F1E/COX4I1/MT-ND6/CYBB/SLC25A6/MT-ATP8/UQCRB/MT-ND4L/ATP5F1D/NDUFS6/COX6B1/WNT2/COX4I2/CALM1/NDUFB10/UQCRQ/NDUFS7/TUBA1B/PIK3R1/PLCB2/UQCR10/NDUFB11/NDUFB7/NDUFA3/NRAS/PSMA7	3.86919445137923
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/492	212/9376	2.15738610216291	HGF/CSF1R/FYB1/ITGB2/FPR1/TLN1/ITGAL/PFN1/FGF7/ITGAM/LCP2/RAC2/CALM1/VAV1/RAC1/IGF1/PIK3R1/PLCB2/PRKCB/GNAI2/VAV3/EVL/NRAS/P2RY1	4.01113766869513
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	43/492	480/9376	1.70718157181572	MT-ND1/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND3/MT-ND5/UBA52/ATP5F1E/COX4I1/MT-ND6/RPS27A/TNFRSF1B/CYBB/GPX3/SLC25A6/MT-ATP8/UQCRB/MT-ND4L/UBB/ATP5F1D/NDUFS6/COX6B1/WNT2/COX4I2/CALM1/NDUFB10/RAC1/UQCRQ/NDUFS7/TUBA1B/PLCB2/UQCR10/PRKCB/NDUFB11/RYR1/NDUFB7/NDUFA3/NRAS/PSMA7	3.7429849531354
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/492	204/9376	2.14857325043839	HGF/COL1A1/COL1A2/RPS6/PTPN6/HBEGF/FLNA/CCND1/WNT2/MMP2/VAV1/TLR4/HCLS1/RAC1/IGF1/PIK3R1/CD44/PRKCB/PPP1CA/VAV3/PAK1/GRB2/NRAS	3.90306400281611
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/492	109/9376	2.62251062877601	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/CD4/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-DQA1/HSP90AB1/IL2RG/CD247/CD3E/IL6R	4.00954537437583
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	19/492	157/9376	2.30625032364973	MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX4I1/UQCRB/NDUFS6/COX6B1/COX4I2/NDUFB10/RAC1/UQCRQ/NDUFS7/PIK3R1/UQCR10/NDUFB11/NDUFB7/IL6R/NDUFA3	3.88417013265615
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/492	87/9376	2.84758433791235	MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX4I1/UQCRB/TPM1/TPM3/TNNT2/COX6B1/COX4I2/UQCRQ/UQCR10	4.07420926041612
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/492	66/9376	3.17615176151761	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-DQB1/HLA-DQA1/TLR4/IL2RG	4.17493983300293
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	24/492	224/9376	2.0418118466899	HLA-DRA/HLA-DRB5/SPI1/HLA-DRB1/ITGB2/HLA-DPA1/SLC25A6/HLA-DPB1/CD4/HLA-A/HLA-DMB/TLN1/HLA-DMA/ITGAL/HLA-DQB1/HLA-E/CCND1/HLA-DQA1/TSPO/IL2RG/PIK3R1/NRP1/CD3E/NRAS	3.7138059670517
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/492	100/9376	2.6679674796748	CXCL14/CCL4/CSF1R/CCL3/TNFRSF1B/CCL5/CXCR4/CCR1/CCL4L2/IL10RA/IL2RG/TNFSF10/IL6R/CCL2	3.94612759405059
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/492	89/9376	2.78359367863342	SPP1/COL1A1/COL6A2/CD36/COL1A2/TNXB/LAMB1/LAMA4/LAMC1/LAMA2/COL6A1/CD44/ITGA4	3.97847945469808
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/492	68/9376	3.08273553323769	CD14/CSF1R/SPI1/FCGR1A/CCND1/BCL2A1/ITGAM/PIK3R1/DUSP6/GRB2/NRAS	4.0562462273768
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/492	149/9376	2.30217711573089	MT-ND1/MT-ND4/MT-ND2/MT-ND3/MT-ND5/MT-ND6/MT-ND4L/NDUFS6/GNG2/NDUFB10/KCNJ5/NDUFS7/PLCB2/PRKCB/GNAI2/NDUFB11/NDUFB7/NDUFA3	3.77048178778736
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/492	214/9376	2.04817263125902	TNFRSF1B/CFL1/ELOB/CD4/HLA-A/CXCR4/APOBEC3A/GNG2/HLA-E/AP1B1/RAC2/CALM1/TLR4/RAC1/PIK3R1/CD247/PRKCB/GNAI2/PTK2B/CD3E/SAMHD1/PAK1/NRAS	3.65013118579763
Organismal Systems	Immune system	hsa04611	Platelet activation	16/492	126/9376	2.41992515163247	FCER1G/COL1A1/COL1A2/FCGR2A/COL3A1/TLN1/SYK/VAMP8/LCP2/TBXAS1/PIK3R1/PLCB2/BTK/GNAI2/PPP1CA/P2RY1	3.77610248657526
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/492	216/9376	2.02920806985848	CD14/CYBA/CCL3/CYBB/POU2F2/CD36/NCF1/CCL5/NCF4/HSP90AB1/PYCARD/NCF2/CALM1/VAV1/TLR4/RAC1/TNFSF10/PIK3R1/NLRP3/PLCB2/VAV3/NRAS/CCL2	3.60119166399834
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/492	205/9376	2.04513186595281	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DMB/RBPJ/HLA-DMA/ITGAL/SYK/HLA-DQB1/HLA-E/CCND1/HLA-DQA1/RAC1/PIK3R1/RUNX3/CD44/BTK/CD247/CD3E	3.56043931527838
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/492	232/9376	1.97140454163162	ITGB2/CFL1/MYL9/NCKAP1L/IQGAP2/CXCR4/ARPC2/ITGAL/PFN1/FGF7/ITGAM/RAC2/VAV1/RAC1/SCIN/ITGAX/PIK3R1/ITGA4/PPP1CA/MYH10/VAV3/FGD3/PAK1/NRAS	3.52565593752029
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/492	143/9376	2.2655068508727	C1QA/C1QB/HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DPB1/FCGR2A/C1QC/HLA-DMB/FCGR1A/HLA-DMA/HLA-DQB1/HLA-DQA1/CD28/FCGR3A/CD86	3.58859969735111
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/492	173/9376	2.09295549602895	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/SLC25A6/HLA-DPB1/CCL5/HLA-DMB/HLA-DMA/HLA-DQB1/TLR7/HLA-DQA1/PYCARD/TLR4/TNFSF10/PIK3R1/NLRP3/PRKCB/CCL2	3.41448126014459
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	23/492	227/9376	1.93087640127503	CCL4/CCL3/CCL5/HLA-A/CXCR4/CCR1/GNG2/HLA-E/CCND1/CCL4L2/RAC2/IL10RA/CALM1/RAC1/PIK3R1/PLCB2/PRKCB/GNAI2/PTK2B/IL6R/GRB2/NRAS/CCL2	3.34104288389183
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/492	362/9376	1.68458877958945	SPP1/HGF/CSH1/CSF1R/COL1A1/COL6A2/CSH2/COL1A2/RPS6/TNXB/YWHAB/SYK/LAMB1/GNG2/CCND1/LAMA4/FGF7/CSF3R/HSP90AB1/LAMC1/TLR4/IL2RG/RAC1/LAMA2/IGF1/COL6A1/PIK3R1/ITGA4/FLT3LG/IL6R/GRB2/NRAS	3.12600162769053
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/492	103/9376	2.40524113979004	C1QA/C1QB/CCL3/CCL5/C1QC/TLR4/PIK3R1/PLCB2/CD247/GNA15/GNAI2/CD3E/CCL2	3.37460738664881
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/492	180/9376	2.01156278229449	CD74/HLA-DRA/HLA-DRB5/HLA-DRB1/POU2F2/HLA-DPA1/HLA-DPB1/CCL5/HLA-A/HLA-DMB/HLA-DMA/SYK/HLA-DQB1/HLA-E/HLA-DQA1/PIK3R1/CFP/PPP1CA/CCL2	3.22473126427279
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/492	101/9376	2.26418739434919	COL1A1/CYBB/COL1A2/COL3A1/CCND1/MMP2/RAC1/PIK3R1/PLCB2/PRKCB/NRAS/CCL2	3.00593162711141
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/492	65/9376	2.63864915572233	SPP1/CGA/ARRB2/KCNJ5/KISS1/PIK3R1/PLCB2/PRKCB/NRAS	3.11966821570778
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/492	200/9376	1.81040650406504	RPS3/CYTH4/MYO1F/NCL/NCKAP1L/FCGR2A/PTPN6/ARPC2/PYCARD/TLR4/HCLS1/RAC1/TNFSF10/MYO1G/TUBA1B/NLRP3/NAIP/MYH10/PAK1	2.72618376972521
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/492	122/9376	2.0306544049047	PTPRC/CD4/PTPN6/CD28/LCP2/VAV1/PIK3R1/CD247/CD3E/VAV3/PAK1/GRB2/NRAS	2.69644859996766
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/492	37/9376	3.09030982201714	HBB/HBA2/HBA1/LAMA4/PLCB2/PRKCB	2.99795597000135
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/492	154/9376	1.85619258789991	MEF2C/EEF2/MYL9/CCND1/CALM1/RGS2/KCNJ5/MYL6/TRPM2/PLCB2/PRKCB/GNAI2/RYR1/PPP1CA/NRAS	2.52105998915527
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/492	63/9376	2.41992515163247	PLA2G2A/GPX4/TBXAS1/LTC4S/HPGDS/HPGD/PTGDS/ALOX5	2.66106106054846
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/492	142/9376	1.87885033779915	CYBA/MEF2C/PECAM1/NCF1/HMOX1/GSTP1/HSP90AB1/MMP2/NCF2/RAC2/CALM1/RAC1/PIK3R1/CCL2	2.48329363693098
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/492	52/9376	2.56535334584115	PLTP/APOE/APOC1/CD36/NPC2/TSPO/SORT1	2.66364804569014
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/492	42/9376	2.72241579558653	FTL/CYBB/SLC40A1/HMOX1/GPX4/NCOA4	2.63264718647695
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/492	105/9376	1.99643825009679	FCER1G/CD209/SYK/LSP1/PYCARD/CALM1/CLEC7A/PIK3R1/NLRP3/PAK1/NRAS	2.41627112502031
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/492	253/9376	1.58179890099296	CD14/UBA52/RPS27A/CYTH4/MYL9/CCL5/UBB/TLN1/ARPC2/PFN1/CAPNS1/PYCARD/TLR4/HCLS1/RAC1/PIK3R1/NLRP3/CD44/PLCB2/NAIP/RRAGB	2.20763989801934
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/492	56/9376	2.38211382113821	CD14/ITGB2/CR1/PYCARD/ITGAM/TLR4/NAIP	2.44114615425376
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/492	109/9376	1.92317446110241	SPP1/CD14/CCL4/CCL3/CCL5/TLR7/CCL4L2/TLR4/RAC1/CD86/PIK3R1	2.28134708309887
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/492	201/9376	1.61177850584476	CD14/CSF1R/SPI1/MEF2C/PROM1/NUPR1/FCGR1A/BCL2A1/ITGAM/HPGD/REL/IGF1/CD86/LYL1/SPINT1/DUSP6/FLI1	2.06325602202347
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/492	248/9376	1.53684762654078	CD14/RPS3/PTPRC/CYTH4/MYL9/NCKAP1L/ARPC2/PFN1/FLNA/HSP90AB1/PYCARD/TLR4/RAC1/TNFSF10/TUBA1B/S100A10/NLRP3/RHOG/NAIP/PAK1	2.01628990967706
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/492	130/9376	1.75909943714822	COL1A1/COL1A2/COL3A1/ARRB2/GNG2/MMP2/PIK3R1/PLCB2/GNA15/GNAI2/GRB2/NRAS	2.0509605916228
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	23/492	298/9376	1.47083537949473	CSH1/CXCL14/CCL4/CSF1R/CCL3/TNFRSF1B/CSH2/CD4/CCL5/CXCR4/IL1RN/CCR1/LTB/CSF2RA/CSF3R/CCL4L2/IL10RA/IL2RG/TNFSF10/TNFRSF11A/CXCL16/IL6R/CCL2	1.9437752439325
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/492	37/9376	2.57525818501428	TPM3/CCND1/NCOA4/TPR/NRAS	2.25926062745082
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/492	38/9376	2.50748823277706	PTPRC/CD4/IL2RG/BTK/CD3E	2.1912034798293
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/492	105/9376	1.81494386372435	CD14/CCL4/SYK/LTB/BCL2A1/CCL4L2/TLR4/TNFRSF11A/BTK/PRKCB	1.97616392810931
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/492	106/9376	1.79782175180242	FOLR2/GSTP1/CCND1/HSP90AB1/IGF1/PIK3R1/SPINT1/GRB2/NRAS/FOLR3	1.94393998526204
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/492	196/9376	1.55566616890659	UBA52/RPS27A/UBB/HLA-A/SYK/CCR1/GNG2/HLA-E/CCND1/HCK/CALM1/RAC1/CD86/PIK3R1/PREX1/NRAS	1.85005468530458
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/492	93/9376	1.84421715184894	CGA/HBEGF/MMP2/CALM1/PLCB2/PRKCB/PTK2B/GRB2/NRAS	1.92537525128787
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/492	137/9376	1.66921844400926	CTSD/CTSS/CTSC/CTSZ/CTSB/BCL2A1/CTSW/TNFSF10/TUBA1B/PIK3R1/PMAIP1/NRAS	1.85686194813463
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/492	17/9376	3.36298421807748	NRP2/CD209/MYH10	2.29474521409237
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/492	53/9376	2.15738610216291	AP2S1/CLTC/ATP2B1/PLCB2/PRKCB/AP2M1	1.98839320530093
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/492	80/9376	1.90569105691057	HGF/RPS6/IGF1/PIK3R1/PRKCB/IL6R/GRB2/NRAS	1.9144363422772
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/492	110/9376	1.73244641537324	CYBB/ELOB/RPS6/HMOX1/LDHB/TLR4/IGF1/PIK3R1/PRKCB/IL6R	1.81840227967353
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/492	233/9376	1.47220768345023	COL1A1/COL6A2/COL1A2/MYL9/TPM1/TPM3/COL3A1/TLN1/TNNT2/LAMA2/BGN/DSC2/COL6A1/TNNT1/ITGA4/MYH10/FMNL1/TNNT3	1.71763374844897
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	15/492	187/9376	1.52862919003522	CYBA/CYBB/CTSB/CCL5/GPSM3/HSP90AB1/PYCARD/TLR4/NLRP3/TRPM2/PLCB2/PSTPIP1/NAIP/GABARAP/CCL2	1.71831085098536
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	16/492	205/9376	1.48736862978386	HLA-A/YWHAB/RBPJ/ATP6V0D1/SYK/HLA-E/CCND1/RAC1/SCIN/REL/CHD4/PIK3R1/PMAIP1/HDAC5/GRB2/NRAS	1.66031338919501
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/492	70/9376	1.90569105691057	HGF/ELOB/RAC1/PIK3R1/PAK1/GRB2/NRAS	1.78982879155365
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/492	71/9376	1.87885033779915	CCL5/HBEGF/ATP6V0D1/ATP6V0B/RAC1/ATP6V1F/PAK1	1.74924170951676
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/492	103/9376	1.66516694293157	COL14A1/COL1A1/COL6A2/COL1A2/COL3A1/SLC16A10/COL15A1/COL21A1/COL6A1	1.5973609193557
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/492	60/9376	1.90569105691057	IGF1/PLCB2/PRKCB/GNAI2/RYR1/NRAS	1.65616986947555
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/492	90/9376	1.69394760614273	CD4/PTPN6/CD28/TLR4/PIK3R1/CD247/CD3E/NRAS	1.55667342607666
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/492	105/9376	1.63344947735192	UBA52/RPS27A/UBB/TAX1BP1/FKBP8/TOMM7/MUL1/GABARAP/NRAS	1.53605673119832
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/492	76/9376	1.75524176294395	CCND1/CALM1/IGF1/PIK3R1/PRKCB/GRB2/NRAS	1.55566196585321
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/492	122/9376	1.5620418499267	CSH1/CSH2/IGF1/PIK3R1/SSTR1/PLCB2/PRKCB/GNAI2/GRB2/NRAS	1.47044145170873
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/492	333/9376	1.31624307234063	SPP1/COL1A1/COL6A2/COL1A2/TNXB/HLA-A/RBPJ/ATP6V0D1/LAMB1/HLA-E/ATP6V0B/CCND1/WNT2/LAMA4/LAMC1/LAMA2/CHD4/COL6A1/PIK3R1/ITGA4/ATP6V1F/GRB2/NRAS	1.3827726676937
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/492	250/9376	1.37209756097561	DAB2/FOLR2/CYTH4/AP2S1/CLTC/HLA-A/CXCR4/ARPC2/ARRB2/HLA-E/VPS28/IL2RG/SH3KBP1/SNX6/ARAP2/AP2M1/RNF41/FOLR3	1.40329995111549
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/492	139/9376	1.50810083640405	CTSD/HBEGF/HSP90AB1/MMP2/CALM1/KCNJ5/PIK3R1/PLCB2/GNAI2/GRB2/NRAS	1.42022042037647
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/492	140/9376	1.49732868757259	SPP1/MEF2C/RPS6/GNG2/CCND1/CALM1/PLCB2/HDAC5/GNAI2/RYR1/NRAS	1.39517755808299
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/492	125/9376	1.52455284552846	FCER1G/CTSD/RAC2/RAC1/ASAH1/PIK3R1/PLCB2/PRKCB/GNAI2/NRAS	1.38935691819684
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/492	67/9376	1.70658900618857	CALM1/PLCB2/PRKCB/PPP1CA/NRAS/RPS6KA1	1.36589299205299
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/492	99/9376	1.53995236922066	CALM1/HRH1/IGF1/PIK3R1/PLCB2/PRKCB/PPP1CA/TRPV1	1.27096381098981
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/492	134/9376	1.42215750515714	MYL9/PLA2G2A/CALD1/CALM1/MYL6/PLCB2/PPP1R14A/PRKCB/PPP1CA/MYH10	1.15826476835219
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/492	41/9376	1.85921078722982	HBEGF/CCND1/MMP2/NRAS	1.29747322004222
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/492	71/9376	1.61044314668499	CGA/CCND1/TNFRSF11A/PIK3R1/GRB2/NRAS	1.21501075614773
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/492	87/9376	1.53331464349126	CCND1/RAC2/RAC1/PIK3R1/PMAIP1/GRB2/NRAS	1.17604128517499
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/492	169/9376	1.35315341319094	UBA52/CTSD/RPS27A/CTSB/UBB/VAMP8/TAX1BP1/PIK3R1/RRAGB/GABARAP/HMGB1/NRAS	1.09021362010975
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/492	120/9376	1.42926829268293	ARHGDIB/CALM1/RAC1/PIK3R1/SORT1/SH2B3/GRB2/NRAS/RPS6KA1	1.11370886289934
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/492	73/9376	1.56632141663882	HGF/CCND1/FGF7/IGF1/PIK3R1/NRAS	1.14308051003735
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/492	73/9376	1.56632141663882	HGF/CCND1/PIK3R1/PRKCB/GRB2/NRAS	1.14308051003735
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/492	238/9376	1.28113684498189	HGF/CSF1R/GNG2/FGF7/PLA2G2A/RAC2/CALM1/RAC1/REL/IGF1/PIK3R1/FLT3LG/PRKCB/PAK1/GRB2/NRAS	1.03381917487264
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/492	29/9376	1.97140454163162	RASSF4/RASSF2/PAK1	1.23289735781551
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/492	157/9376	1.33519755579721	C1QA/C1QB/STAB1/PECAM1/CD36/C1QC/PTPN6/RAC1/HAVCR2/DUSP2/ALOX5	0.996718860998344
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/492	60/9376	1.58807588075881	RAC2/RAC1/PIK3R1/PRKCB/NRAS	1.07537062141291
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/492	158/9376	1.32674693835546	RPS6/LAMTOR4/WNT2/IGF1/PIK3R1/ATP6V1F/PRKCB/RRAGB/GRB2/NRAS/RPS6KA1	0.974732918278146
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/492	226/9376	1.26483919706454	MYL9/CGA/ATP2B1/CFTR/RAC2/CALM1/VAV1/RAC1/FXYD1/PIK3R1/SSTR1/GNAI2/PPP1CA/VAV3/PAK1	0.948396297211606
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/492	61/9376	1.5620418499267	FTL/SLC40A1/HMOX1/ATP2B1/ATOX1	1.03634905827661
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/492	31/9376	1.84421715184894	SEC62/SRP14/BAG6	1.10792223949077
NA	NA	hsa04981	Folate transport and metabolism	3/492	31/9376	1.84421715184894	FOLR2/SLCO2B1/FOLR3	1.10792223949077
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/492	78/9376	1.46591619762351	CLTC/ARPC2/HCLS1/RAC1/PIK3R1/RHOG	0.972353661832931
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	19/492	300/9376	1.20693766937669	HGF/CD14/CSF1R/MEF2C/ARRB2/FLNA/FGF7/RAC2/RAC1/IGF1/FLT3LG/PRKCB/DUSP2/PTPN7/DUSP6/PAK1/GRB2/NRAS/RPS6KA1	0.857268472215729
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/492	79/9376	1.44736029638777	AP2S1/CLTC/ATP6V0D1/ATP6V0B/ATP6V1F/AP2M1	0.939644297086726
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/492	32/9376	1.78658536585366	LDHB/HADHA/ACSS1	1.04886199964576
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/492	97/9376	1.37524096890453	GNG2/CALM1/KCNJ5/PLCB2/PRKCB/GNAI2/RYR1	0.874197264327813
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/492	115/9376	1.32569812654648	MEF2C/HBEGF/ARRB2/MAFB/PLCB2/PRKCB/GNAI2/NR4A2	0.826987896045031
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/492	184/9376	1.24284199363733	CFL1/MYL9/CXCR4/EPHA3/RAC2/RAC1/PIK3R1/SLIT3/NRP1/GNAI2/PAK1/NRAS	0.7828735276138
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/492	99/9376	1.34745832306808	HBEGF/CCND1/MMP2/IGF1/PIK3R1/GRB2/NRAS	0.81786279609093
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/492	99/9376	1.34745832306808	WAS/RAC2/RAC1/PIK3R1/PRKCB/GRB2/NRAS	0.81786279609093
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/492	168/9376	1.24777390631049	CSH1/CSH2/PTPN6/CSF2RA/CCND1/CSF3R/IL10RA/IL2RG/PIK3R1/IL6R/GRB2	0.762590635692204
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/492	83/9376	1.3776079929474	CCL4/CCL5/CCL4L2/PYCARD/NLRP3/SAMHD1	0.813141582895373
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/492	51/9376	1.49465965247888	ATP6V0D1/ATP6V0B/CFTR/ATP6V1F	0.833548876545559
Human Diseases	Infectious disease: viral	hsa05162	Measles	9/492	136/9376	1.26111908177905	RACK1/CD209/CCND1/TLR7/CD28/TLR4/IL2RG/PIK3R1/CD3E	0.721831770580511
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/492	52/9376	1.46591619762351	CGA/CYP1B1/IGF1/ALOX5	0.792815738729186
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/492	86/9376	1.32955190017016	HBEGF/PIK3R1/PRKCB/PAK1/GRB2/NRAS	0.722485446706759
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/492	21/9376	1.81494386372435	ENPP1/VNN2	0.879790686270135
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/492	38/9376	1.50449293966624	IGF1/PIK3R1/PRKCB	0.733303690808613
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/492	89/9376	1.28473554398465	TUBA1B/PLCB2/PRKCB/GNAI2/GRB2/NRAS	0.63513036928522
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/492	254/9376	1.12540810447475	HGF/SLC25A6/CXCR4/ATP2B1/FGF7/PTAFR/CALM1/HRH1/PLCB2/PRKCB/GNA15/MCOLN1/PTK2B/RYR1/ORAI3	0.476827552863477
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/492	93/9376	1.22947810123263	LMO7/MYL9/PTPN6/WAS/RAC2/RAC1	0.523362331431155
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/492	93/9376	1.22947810123263	CST3/LYZ/ATP2B1/CALM1/PLCB2/PRKCB	0.523362331431155
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/492	93/9376	1.22947810123263	LAMB1/CCND1/LAMA4/LAMC1/LAMA2/PIK3R1	0.523362331431155
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/492	76/9376	1.25374411638853	CFTR/CALM1/PLCB2/PRKCB/GNAI2	0.522667164731417
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/492	59/9376	1.29199393688852	GPX3/GSTP1/GPX4/HPGDS	0.529450918851628
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/492	59/9376	1.29199393688852	CCND1/PIK3R1/GRB2/NRAS	0.529450918851628
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/492	42/9376	1.36120789779326	AOC1/CYP1B1/HADHA	0.55209256574129
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/492	133/9376	1.1462803349838	ARRB2/GNG2/CALM1/KCNJ5/PLCB2/PRKCB/GNAI2/PPP1CA	0.399824317721687
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/492	115/9376	1.15998586072817	GNG2/KCNJ5/PLCB2/PRKCB/GNAI2/NRAS/ALOX5	0.406223922020817
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	10/492	170/9376	1.12099473935916	MYL9/ARPC2/WAS/CCND1/CFTR/HCLS1/RAC1/MYL6/TUBA1B/MYH10	0.374644514776595
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/492	98/9376	1.16674962667994	ATP2B1/CALM1/KCNJ5/PLCB2/PRKCB/NR4A2	0.390494245849276
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/492	10/9376	1.90569105691057	SELENBP1	0.674321360912147
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/492	99/9376	1.1549642769155	TPM1/TPM3/TNNT2/LAMA2/IGF1/ITGA4	0.364761781192055
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/492	28/9376	1.36120789779326	TECR/HADHA	0.450444009979475
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/492	28/9376	1.36120789779326	ATP6V0D1/ATP6V1F	0.450444009979475
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/492	46/9376	1.24284199363733	FTL/BLVRB/HMOX1	0.388531109441798
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/492	101/9376	1.1320936971746	WNT2/CALM1/PLCB2/PRKCB/GNAI2/NRAS	0.314086838592157
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/492	194/9376	1.08054647556785	MYL9/MYO1F/TPM1/TPM3/TNNT2/MYL6/MYO1G/TUBA1B/TNNT1/MYH10/TNNT3	0.266773494288636
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/492	102/9376	1.12099473935916	ATP2B1/PLA2G2A/CFTR/RAC1/PLCB2/PRKCB	0.289132521122105
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/492	178/9376	1.07061295332054	FRZB/SERPINF1/CCND1/WNT2/RAC2/RAC1/PLCB2/PRKCB/RSPO2/CBY1	0.22382654399476
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/492	48/9376	1.19105691056911	PIK3R1/PLCB2/PRKCB	0.312286359904547
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/492	30/9376	1.27046070460705	FOLR2/FOLR3	0.349153040874477
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/492	105/9376	1.08896631823461	TPM1/TPM3/TNNT2/LAMA2/IGF1/ITGA4	0.21573514046533
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/492	12/9376	1.58807588075881	CD209	0.479686176070732
NA	NA	hsa04081	Hormone signaling	12/492	219/9376	1.04421427775922	CSH1/CSH2/SLC40A1/CGA/GNG2/SLC16A10/IGF1/PIK3R1/SSTR1/PLCB2/GNA15/GNAI2	0.155801595279353
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/492	144/9376	1.05871725383921	C1QA/CD14/C1QB/C5AR1/C1QC/C3AR1/CCND1/TLR4	0.167094824515269
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/492	31/9376	1.22947810123263	TKT/PGLS	0.301159353698175
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/492	69/9376	1.10474843878874	CTSB/CALM1/PLCB2/GNAI2	0.205509149465252
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/492	51/9376	1.12099473935916	PLD3/ENPP2/PLA2G2A	0.203887720689036
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/492	166/9376	1.03320599471055	MEF2C/SLC25A6/MYL9/ATP2B1/CALM1/RGS2/PLCB2/GNAI2/PPP1CA	0.101579164866751
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/492	109/9376	1.0490042515104	CD36/PIK3R1/PRKCB/PPP1CA/SLC27A3/RPS6KA1	0.121099219002663
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/492	33/9376	1.1549642769155	VAMP8/VAMP5	0.209850159813247
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/492	91/9376	1.04708299830251	ARRB2/GNG2/KCNJ5/PRKCB/GNAI2	0.106208131445226
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/492	168/9376	1.02090592334495	FTL/CYBB/SLC25A6/HSP90AB1/PYCARD/TLR4/TNFSF10/NLRP3/HMGB1	0.0643435848865299
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/492	149/9376	1.02318982921373	FCER1G/CYTH4/SYK/PIK3R1/PLCB2/PTK2B/GRB2/NRAS	0.0671466482216479
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/492	73/9376	1.04421427775922	CD4/CXCR4/APOBEC3A/SAMHD1	0.0892434537826605
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/492	170/9376	1.00889526542324	HGF/HMOX1/GSTP1/CCND1/WNT2/PIK3R1/PRKCB/GRB2/NRAS	0.0275430354736945
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/492	133/9376	1.00299529311083	CCND1/TNFSF10/IGF1/PIK3R1/GABARAP/GRB2/NRAS	0.00818695844896046
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/492	55/9376	1.03946784922395	PSAP/ASAH1/GM2A	0.0690808170998573
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/492	75/9376	1.01636856368564	CCND1/IGF1/PMAIP1/ZNF385A	0.033491939391303
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/492	75/9376	1.01636856368564	GPX3/CGA/PLCB2/PRKCB	0.033491939391303
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/492	154/9376	0.989969380213283	TPM1/TPM3/TNNT2/ATP2B1/CALM1/PLCB2/GNAI2/PPP1CA	-0.0295351706708288
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/492	115/9376	0.994273594909862	GNG2/PIK3R1/PLCB2/PRKCB/GNAI2/NRAS	-0.0145400520033964
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/492	77/9376	0.989969380213283	CCND1/RAC2/RAC1/PIK3R1	-0.020797873007063
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/492	77/9376	0.989969380213283	CCND1/PIK3R1/GRB2/NRAS	-0.020797873007063
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/492	157/9376	0.971052767852519	SLC25A6/HLA-A/HLA-E/CCND1/CALM1/PIK3R1/PPP1CA/NRAS	-0.0860753658733313
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/492	98/9376	0.972291355566617	INPP5D/CALM1/PIK3R1/PLCB2/PRKCB	-0.0648880985640092
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/492	217/9376	0.966018508111348	ARRB2/CCND1/FGF7/HSP90AB1/CYP1B1/PIK3R1/PRKCB/GNAI2/GRB2/NRAS/RPS6KA1	-0.119182418436134
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/492	38/9376	1.00299529311083	ENPP1/QPRT	0.00435379629826999
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/492	59/9376	0.968995452666391	CGA/PIK3R1/GNAI2	-0.0562182429172327
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/492	18/9376	1.05871725383921	ABCD4	0.0586778756632934
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/492	122/9376	0.937225109956018	CD36/EEF2/CCND1/CFTR/IGF1/PIK3R1	-0.164234745969839
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/492	122/9376	0.937225109956018	CCND1/SLC16A10/PIK3R1/PLCB2/PRKCB/NRAS	-0.164234745969839
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/492	144/9376	0.926377597109304	SLC25A6/RBPJ/PIK3R1/PLCB2/PRKCB/RYR1/PSMA7	-0.209511203046068
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/492	62/9376	0.922108575924469	IGF1/PIK3R1/NRAS	-0.144804242685552
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/492	85/9376	0.896795791487327	ENPP1/ADA2/GUK1/NME4	-0.224925945622036
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/492	148/9376	0.901340364754999	CCND1/WNT2/FGF7/IGF1/PIK3R1/GRB2/NRAS	-0.284695422862877
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/492	43/9376	0.886367933446776	CD36/PLA2G2A	-0.175747199970282
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/492	108/9376	0.882264378199338	NUP93/PNN/DDX19A/CASC3/TPR	-0.289594734837061
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/492	150/9376	0.889322493224932	HGF/CCND1/WNT2/FGF7/PIK3R1/GRB2/NRAS	-0.321560123133663
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/492	110/9376	0.866223207686622	HSP90AB1/IGF1/PIK3R1/GNAI2/RPS6KA1	-0.332119891645721
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/492	45/9376	0.846973803071364	CFTR/ABCD4	-0.242142968324874
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/492	89/9376	0.856490362656436	GNG2/PRKCB/GNAI2/GABARAP	-0.320112226547026
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/492	22/9376	0.866223207686622	AOC1	-0.147828221003599
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/492	46/9376	0.828561329091552	PSME1/PSMA7	-0.274290521221648
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/492	69/9376	0.828561329091552	CALM1/PRKCB/PPP1CA	-0.336350745187787
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/492	47/9376	0.810932364642795	LDHB/ACSS1	-0.305782403280193
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/492	70/9376	0.816724738675958	GSTP1/CYP1B1/HPGDS	-0.362189001419808
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/492	71/9376	0.805221573342494	LDHB/PIK3R1/NRAS	-0.387682103959349
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/492	94/9376	0.810932364642795	S100A9/S100A8/HSP90AB1/CCL2	-0.433535087283555
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/492	138/9376	0.828561329091552	YWHAB/CALM1/IGF1/SMC1A/PPP1CA/RPS6KA1	-0.477444912541188
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/492	138/9376	0.828561329091552	RPS6/CALM1/PIK3R1/PPP1CA/GRB2/NRAS	-0.477444912541188
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/492	117/9376	0.814397887568619	CHD4/BPTF/BAZ1B/VPS72/YY2	-0.475398402815083
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/492	26/9376	0.732958098811757	PLA2G2A	-0.320866365117465
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/492	26/9376	0.732958098811757	ABCD4	-0.320866365117465
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/492	163/9376	0.818394932415582	YWHAB/TLR4/PIK3R1/PRKCB/PTK2B/GRB2/NRAS	-0.550408515505979
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/492	75/9376	0.762276422764228	GSTP1/PIK3R1/PMAIP1	-0.486409424404817
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/492	27/9376	0.70581150255947	HADHA	-0.360237487503954
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/492	27/9376	0.70581150255947	TECR	-0.360237487503954
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/492	76/9376	0.752246469833119	PLTP/CD36/FABP5	-0.510327636390372
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/492	28/9376	0.680603948896632	AKR1B1	-0.398302581171562
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/492	54/9376	0.70581150255947	LDHB/SDS	-0.510189989930606
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/492	29/9376	0.657134847210541	CALM1	-0.43516117420155
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/492	79/9376	0.723680148193887	GSTP1/CYP1B1/HPGDS	-0.580387609311677
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/492	103/9376	0.740074196858473	PNN/DDX19A/PPP1CA/CASC3	-0.624197164760689
NA	NA	hsa04519	Cadherin signaling	18/492	404/9376	0.849070272880946	MYO1F/NCKAP1L/KRT7/PCDH12/YWHAB/ARPC2/WNT2/RAC2/VAV1/RAC1/MYO1G/DSC2/PTK2B/PPP1CA/TMC8/VAV3/EVL/NRAS	-0.729767892052925
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/492	56/9376	0.680603948896632	ST6GAL1/MGAT4A	-0.564130413798139
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/492	56/9376	0.680603948896632	ARRB2/CCND1	-0.564130413798139
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/492	30/9376	0.635230352303523	PLA2G2A	-0.470901796610266
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/492	57/9376	0.66866352874055	TECR/HADHA	-0.59045380999781
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/492	82/9376	0.697204045211184	GSTP1/CES1/NME4	-0.648066504891847
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/492	31/9376	0.614739050616313	HADHA	-0.505603532094422
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/492	31/9376	0.614739050616313	ACSS1	-0.505603532094422
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/492	174/9376	0.766657321745631	RRBP1/SEC62/HSP90AB1/UBXN4/ERP29/NPLOC4/CKAP4	-0.731124946539833
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/492	32/9376	0.595528455284553	AKR1B1	-0.539337307311385
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/492	32/9376	0.595528455284553	GABARAP	-0.539337307311385
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/492	32/9376	0.595528455284553	PMAIP1	-0.539337307311385
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/492	59/9376	0.645996968444261	ENPP1/NME4	-0.641887404686093
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/492	86/9376	0.664775950085082	SCN9A/PLCB2/P2RY1	-0.734920652329938
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/492	86/9376	0.664775950085082	LAMA2/DSC2/ITGA4	-0.734920652329938
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/492	34/9376	0.560497369679579	POLR2D	-0.604150195364759
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/492	34/9376	0.560497369679579	BHLHE41	-0.604150195364759
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/492	35/9376	0.544483159117305	AKR1B1	-0.635339253865286
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/492	36/9376	0.529358626919603	AKR1B1	-0.665781662563126
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/492	36/9376	0.529358626919603	ENPP1	-0.665781662563126
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/492	90/9376	0.635230352303523	IGF1/PIK3R1/NRAS	-0.818256612144954
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/492	116/9376	0.657134847210541	SDS/TKT/PGLS/ACSS1	-0.874401237573699
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/492	116/9376	0.657134847210541	GNG2/PLCB2/PRKCB/GNAI2	-0.874401237573699
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/492	67/9376	0.568863002062856	LDHB/ACSS1	-0.833422256700029
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/492	119/9376	0.640568422490947	TNFRSF1B/CCL5/PIK3R1/CCL2	-0.928578218850081
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/492	191/9376	0.698420806197591	GNG2/CALM1/HDAC5/GNAI2/PPP1CA/GRB2/NRAS	-0.990928670104655
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/492	144/9376	0.661698283649503	WNT2/IGF1/PIK3R1/GRB2/NRAS	-0.962723258168744
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/492	70/9376	0.544483159117305	TNFRSF1B/CD36	-0.900193449663173
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/492	41/9376	0.464802696807456	SDS	-0.808188373158075
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/492	72/9376	0.529358626919603	OTUD5/RNF125	-0.94337728390318
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/492	43/9376	0.443183966723388	HADHA	-0.861190522316939
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/492	73/9376	0.522107138879608	GSTP1/HPGDS	-0.964593602472031
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/492	44/9376	0.433111603843311	MGAT4A	-0.886952689937549
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/492	44/9376	0.433111603843311	HMGB1	-0.886952689937549
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/492	44/9376	0.433111603843311	ARHGDIB	-0.886952689937549
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/492	128/9376	0.595528455284553	ENPP1/ADA2/GUK1/NME4	-1.08425881733128
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/492	75/9376	0.508184281842818	SDS/TKT	-1.00631078820094
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/492	156/9376	0.610798415676464	YWHAB/CCND1/PIK3R1/GRB2/NRAS	-1.15354715594666
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/492	157/9376	0.606907979907825	ITGB2/YWHAB/CCND1/WNT2/PPP1CA	-1.16886959274501
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/492	47/9376	0.405466182321398	PIK3R1	-0.961549972620333
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/492	78/9376	0.488638732541172	INPP5D/PLCB2	-1.06719621139874
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/492	323/9376	0.707996677489995	TPM1/TNXB/HMOX1/CCND1/CYP1B1/ZEB2/PIK3R1/CD44/PRKCB/HDAC5/GRB2/NRAS	-1.2567726143159
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/492	107/9376	0.534305903806702	LDHB/CALM1/PLCB2	-1.14009251554763
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/492	48/9376	0.397018970189702	HADHA	-0.985584611046265
NA	NA	hsa03272	Virion - Hepatitis viruses	1/492	48/9376	0.397018970189702	TGOLN2	-0.985584611046265
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/492	370/9376	0.721072291803999	CSH1/C5AR1/SPX/CSH2/CGA/FPR1/C3AR1/TSPO/PTAFR/KISS1/HRH1/SSTR1/TRPV1/P2RY1	-1.28822126484298
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/492	49/9376	0.388916542226647	ST6GAL1	-1.0092331184783
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/492	49/9376	0.388916542226647	GNAI2	-1.0092331184783
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/492	50/9376	0.381138211382114	AOC1	-1.03251145708699
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/492	83/9376	0.4592026643158	PEX14/ABCD4	-1.16455374297415
NA	NA	hsa04382	Cornified envelope formation	7/492	217/9376	0.614739050616313	S100A9/S100A8/S100A11/KRT7/S100A1/S100A4/S100A10	-1.35121588619489
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/492	86/9376	0.443183966723388	PLCB2/PRKCB	-1.22072268534217
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/492	142/9376	0.536814382228329	UBA52/RPS27A/ELOB/UBB	-1.30878472461053
NA	NA	hsa04082	Neuroactive ligand signaling	6/492	199/9376	0.574580218163991	GNG2/HRH1/PLCB2/PRKCB/GNAI2/P2RY1	-1.42743968796592
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/492	62/9376	0.307369525308156	RBPJ	-1.28763638024426
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/492	155/9376	0.49179124049305	CCND1/WNT2/PLCB2/GNAI2	-1.50135328659491
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/492	63/9376	0.302490643954059	HADHA	-1.30719213235158
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/492	63/9376	0.302490643954059	POLR2D	-1.30719213235158
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/492	63/9376	0.302490643954059	WNT2	-1.30719213235158
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/492	158/9376	0.482453432129258	YWHAB/CCND1/SMC1A/ATRX	-1.54391554205379
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/492	65/9376	0.293183239524703	AKR1B1	-1.3456411790676
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/492	65/9376	0.293183239524703	PLCB2	-1.3456411790676
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/492	66/9376	0.288741069228874	CYP1B1	-1.36454786571713
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/492	104/9376	0.366479049405879	PLD3/PLA2G2A	-1.52881471582569
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/492	83/9376	0.2296013321579	YY2	-1.65897757444153
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/492	90/9376	0.211743450767841	CFTR	-1.7682286274336
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/492	243/9376	0.392117501421928	RBM25/PRPF38B/SNRPD2/GPKOW/CASC3	-2.25933152667049
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/492	110/9376	0.173244641537324	EMP3	-2.05253762870112
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/492	154/9376	0.247492345053321	QPRT/NME4	-2.21575959337892
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/492	449/9376	0.127329023847031	ARRB2/CALM1/RGS2	-4.45948646284716