category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	62/390	238/9376	6.26278819219996	RPL13A/RPS14/RPS11/RPS20/RPS5/RPL18A/RPLP2/RPS2/F13A1/RPL10/RPS16/RPL27A/RPS27A/RPL10A/RPS27/RPS26/RPS28/RPL28/RPL7/RPS8/RPS12/RPS9/RPS15/UBA52/C1QA/RPL21/RPS19/CFD/C1QB/RPLP1/RPL19/RPL13/RPSA/RPS3A/RPS3/CYBB/RPS4X/RPS23/RPL8/C5AR1/RPL30/RPL37A/RPS24/RPL31/RPL18/RPS13/RPL23/RPL34/RPL36AL/RPL15/RPS15A/C7/RPL3/RPL11/RPL29/PIK3R1/RPL37/IRF3/RPL35A/C2/RPS18/RPLP0	17.1322154715393
Genetic Information Processing	Translation	hsa03010	Ribosome	55/390	222/9376	5.95610995610996	RPL13A/RPS14/RPS11/RPS20/RPS5/RPL18A/RPLP2/RPS2/RPL10/RPS16/RPL27A/RPS27A/RPL10A/RPS27/RPS26/RPS28/RPL28/RPL7/RPS8/RPS12/RPS9/RPS15/UBA52/RPL21/RPS19/RPLP1/RPL19/RPL13/RPSA/RPS3A/RPS3/RPS4X/RPS23/RPL8/RPL30/RPL37A/RPS24/RPL31/RACK1/RPL18/RPS13/RPL23/RPL34/MRPS21/RPL36AL/RPL15/RPS15A/RPL3/RPL11/RPL29/MRPS15/RPL37/RPL35A/RPS18/RPLP0	15.5684974839403
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	44/390	138/9376	7.66525455221107	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/MT-ND6/MT-ATP8/ATP5F1D/NDUFS7/NDUFS6/UQCRB/ATP6V0B/NDUFS8/ATP5ME/NDUFB10/NDUFS5/ATP6V0D1/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/ATP5PF/NDUFV3/NDUFV1/COX6A1/NDUFA2/COX7A2/ATP5PO/COX8A/NDUFA10/NDUFA4L2/NDUFS3/ATP5MG/COX4I2	16.4324393867806
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/390	205/9376	5.98093808630394	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COL3A1/COX4I1/MT-ND4L/COL1A1/MT-ND6/CYBA/MT-ATP8/SLC25A6/COL1A2/ATP5F1D/NDUFS7/NDUFS6/UQCRB/CYBB/MMP2/CTSD/NDUFS8/PARP1/NDUFB10/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/ATP5PF/NDUFV3/NDUFV1/COX6A1/PIK3R1/NDUFA2/NCF1/COX7A2/ATP5PO/COX8A/NDUFA10/NDUFA4L2/NDUFS3/COX4I2	15.0215401120068
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	55/390	275/9376	4.80820512820513	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/MT-ND6/CYBA/MT-ATP8/C1QA/SLC25A6/C1QB/ATP5F1D/NDUFS7/NDUFS6/UQCRB/CYBB/PSMA7/ITPR2/NDUFS8/NDUFB10/PSMD7/C7/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/ATP5PF/NDUFV3/NDUFV1/COX6A1/PIK3R1/NDUFA2/NCF1/COX7A2/CCL5/ATP5PO/PSMB6/COX8A/NDUFA10/NDUFA4L2/BAD/PSMD1/NDUFS3/COX4I2	13.3529387791472
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	49/390	227/9376	5.18947249519937	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/MT-ND6/CYBA/HGF/MT-ATP8/SLC25A6/ATP5F1D/NDUFS7/NDUFS6/UQCRB/NDUFS8/NDUFB10/HMOX1/NDUFS5/GSTO1/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/ATP5PF/NDUFV3/NDUFV1/COX6A1/PIK3R1/NDUFA2/NCF1/COX7A2/ATP5PO/AKR1A1/COX8A/NDUFA10/NDUFA4L2/BAD/NDUFS3/COX4I2	13.3112914658627
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	54/390	308/9376	4.21498501498502	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/MT-ND6/GPX3/MT-ATP8/SLC25A6/AP2S1/ATP5F1D/NDUFS7/NDUFS6/UQCRB/PSMA7/NDUFS8/POLR2L/NDUFB10/PSMD7/NDUFS5/COX6B1/NDUFA4/NDUFB11/POLR2I/UQCR10/UQCRC1/ATP5MC1/NDUFA11/RB1CC1/ATP5PF/NDUFV3/NDUFV1/COX6A1/NDUFA2/POLR2G/COX7A2/ATP5PO/PSMB6/REST/COX8A/NDUFA10/NDUFA4L2/CLTB/PSMD1/NDUFS3/DCTN3/COX4I2	11.9517992577887
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	49/390	268/9376	4.39556065824723	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/RPS27A/MT-ND6/UBA52/MT-ATP8/SLC25A6/ATP5F1D/NDUFS7/NDUFS6/UQCRB/PSMA7/ITPR2/NDUFS8/NDUFB10/PSMD7/PARK7/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/ATP5PF/NDUFV3/NDUFV1/COX6A1/NDUFA2/COX7A2/ATP5PO/PSMB6/COX8A/NDUFA10/NDUFA4L2/PSMD1/NDUFS3/COX4I2	11.7490327323049
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	43/390	235/9376	4.39899618112384	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/MT-ND6/MT-ATP8/ATP5F1D/NDUFS7/NDUFS6/UQCRB/NDUFS8/ATP5ME/NDUFB10/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/COX14/NDUFA11/ATP5PF/NDUFV3/NDUFV1/COX6A1/NDUFA2/COX7A2/ATP5PO/COX8A/NDUFA10/NDUFA4L2/NDUFS3/ATP5MG/COX4I2	10.9931584542283
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/390	388/9376	3.22199312714777	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/APOE/COX4I1/MT-ND4L/MT-ND6/MT-ATP8/SLC25A6/ATP5F1D/NDUFS7/NDUFS6/UQCRB/CYBB/PSMA7/ITPR2/NDUFS8/LRP1/NDUFB10/PSMD7/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/RB1CC1/ATP5PF/NDUFV3/NDUFV1/COX6A1/PIK3R1/NDUFA2/COX7A2/ATP5PO/PSMB6/COX8A/NDUFA10/NDUFA4L2/BAD/PSMD1/NDUFS3/COX4I2	9.31240331569903
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/390	368/9376	3.26644370122631	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/MT-ND6/GPX3/MT-ATP8/ATP5F1D/NDUFS7/NDUFS6/UQCRB/PSMA7/NDUFS8/NDUFB10/PSMD7/FUS/VCP/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/RB1CC1/ATP5PF/NDUFV3/NDUFV1/COX6A1/NDUFA2/COX7A2/ATP5PO/PSMB6/COX8A/NDUFA10/NDUFA4L2/BAD/PSMD1/NDUFS3/DCTN3/COX4I2	9.24037062361831
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	57/390	480/9376	2.85487179487179	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-CO2/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/COX4I1/MT-ND4L/RPS27A/MT-ND6/GPX3/UBA52/MT-ATP8/SLC25A6/ATP5F1D/NDUFS7/NDUFS6/UQCRB/CYBB/PSMA7/ITPR2/NDUFS8/NDUFB10/PSMD7/FUS/PARK7/VCP/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/ATP5MC1/NDUFA11/RB1CC1/ATP5PF/NDUFV3/NDUFV1/COX6A1/NDUFA2/COX7A2/ATP5PO/PSMB6/COX8A/NDUFA10/NDUFA4L2/BAD/PSMD1/NDUFS3/DCTN3/COX4I2/ATXN1	8.69104229755618
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	28/390	157/9376	4.28757145190266	MT-CO3/MT-CYB/MT-CO1/MT-CO2/COX4I1/NDUFS7/NDUFS6/UQCRB/NDUFS8/NDUFB10/NDUFS5/COX6B1/NDUFA4/NDUFB11/UQCR10/UQCRC1/NDUFA11/NDUFV3/NDUFV1/COX6A1/PIK3R1/NDUFA2/COX7A2/COX8A/NDUFA10/NDUFA4L2/NDUFS3/COX4I2	8.65401918875198
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	22/390	149/9376	3.54968163827224	MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/MT-ND4L/MT-ND6/NDUFS7/NDUFS6/ITPR2/NDUFS8/NDUFB10/NDUFS5/NDUFA4/NDUFB11/NDUFA11/NDUFV3/NDUFV1/NDUFA2/NDUFA10/NDUFA4L2/NDUFS3	6.53557141867364
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/390	155/9376	3.25717121588089	CYBA/HLA-DRA/CD14/CTSS/HLA-DRB5/ITGB2/HLA-DPA1/CYBB/CTSL/HLA-DRB1/MRC1/ATP6V0B/OLR1/ATP6V0D1/HLA-DPB1/CORO1A/HLA-DMA/COLEC12/NCF1/FCGR1A/HLA-DQB1	5.90304475668111
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/390	87/9376	4.14500442086649	MT-CO3/MT-CYB/MT-CO1/MT-CO2/COX4I1/UQCRB/TPM1/COX6B1/UQCR10/UQCRC1/ATP1B3/COX6A1/COX7A2/COX8A/COX4I2	6.13947364940565
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/390	99/9376	3.88541828541829	KRT18/HLA-DRA/C1QA/CFD/C1QB/HLA-DRB5/ITGB2/HLA-DPA1/HLA-DRB1/C5AR1/HLA-DPB1/HLA-DMA/FPR1/C2/FCGR1A/HLA-DQB1	6.01253106489776
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/390	78/9376	4.00683760683761	CYBA/HLA-DRA/HLA-DRB5/ITGB2/HLA-DPA1/CYBB/HLA-DRB1/HLA-DPB1/HLA-DMA/NCF1/FCGR1A/PTPN6/HLA-DQB1	5.55516852347877
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/390	82/9376	3.81138211382114	CD74/HLA-DRA/CTSS/HLA-DRB5/HLA-DPA1/CTSB/CTSL/HLA-DRB1/CD4/LGMN/HLA-DPB1/HLA-DMA/HLA-DQB1	5.32672411604868
Human Diseases	Immune disease	hsa05310	Asthma	8/390	32/9376	6.01025641025641	HLA-DRA/FCER1G/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	5.91429878921883
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/390	181/9376	2.65646692166029	CD74/HLA-DRA/CD14/FCER1G/CTSS/HLA-DRB5/LSP1/ITGB2/HLA-DPA1/HLA-DRB1/MRC1/CTSD/ATP6V0B/ATP6V0D1/HLA-DPB1/CORO1A/HLA-DMA/FCGR1A/BAD/HLA-DQB1	4.68792789325425
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	23/390	233/9376	2.37314845383515	COL3A1/FBLN1/COL1A1/COL6A2/DCN/FBN1/COL1A2/COL6A1/VCAN/PDLIM7/TPM1/BGN/FMNL1/HSPG2/MYL9/PLEC/MYH10/ATP1B3/DSP/DAAM1/COL5A1/MYH11/DES	4.42166491384064
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/390	95/9376	3.28982456140351	HLA-DRA/HLA-DRB5/CCL3/ITGB2/HLA-DPA1/CTSL/HLA-DRB1/ATP6V0B/ATP6V0D1/HLA-DPB1/HLA-DMA/CCL5/HLA-DQB1	4.6730600336734
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/390	50/9376	4.32738461538461	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/CXCR4/LTBR/HLA-DQB1	4.91445129651261
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/390	100/9376	3.12533333333333	HLA-DRA/CD14/HLA-DRB5/CSF1R/HLA-DPA1/CD37/CSF3R/HLA-DRB1/CD4/HLA-DPB1/HLA-DMA/FCGR1A/HLA-DQB1	4.45124417412941
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/390	88/9376	3.27832167832168	F13A1/C1QA/CFD/C1QB/SERPINE2/ITGB2/SERPINA1/C5AR1/VSIG4/C7/PLAUR/C2	4.47332044455554
NA	NA	hsa04518	Integrin signaling	16/390	154/9376	2.4977688977689	SPP1/COL1A1/COL6A2/HGF/FBN1/COL1A2/COL6A1/ITGB2/ACTN1/IGF1/CCND2/TNXB/LAMB2/PIK3R1/FLNA/PDGFRA	3.90415763022653
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	22/390	250/9376	2.11561025641026	CTSS/CD68/AP2S1/VAMP8/CTSB/NPC2/CTSL/LAMTOR4/LITAF/CTSD/ATP6V0B/LGMN/SLC11A1/ATP6V0D1/HGSNAT/CTSC/TPP1/LAPTM5/CTSZ/CTSA/VPS35/CLTB	3.72457741109279
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/390	39/9376	4.31505588428665	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	4.32169598567535
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/390	54/9376	3.56163342830009	CGA/HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	3.9327292398942
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/390	44/9376	3.82470862470862	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	3.91243705726726
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/390	45/9376	3.7397150997151	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	3.83779966023361
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/390	250/9376	1.92328205128205	DAB2/AP2S1/FOLR2/CYTH4/RAB11FIP1/RAB31/SMAP2/VPS28/CHMP2A/USP8/ARRB2/PDGFRA/SH3GLB2/ARPC5/CXCR4/SNX6/VPS35/ARRB1/CLTB/EHD1	3.08247029149573
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/390	93/9376	2.58505652054039	HLA-DRA/HLA-DRB5/MAF/HLA-DPA1/HLA-DRB1/CD4/HLA-DPB1/HLA-DMA/JAG2/HLA-DQB1	3.20019753754469
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/390	66/9376	2.91406371406371	HLA-DRA/HLA-DRB5/MAF/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	3.25078503679091
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/390	143/9376	2.18554778554779	HLA-DRA/C1QA/C1QB/HLA-DRB5/HLA-DPA1/HLA-DRB1/ACTN1/C7/HLA-DPB1/HLA-DMA/C2/FCGR1A/HLA-DQB1	2.97611973134918
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/390	42/9376	3.43443223443223	FTL/FTH1/SAT1/CYBB/SLC40A1/HMOX1	3.29399678846023
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/390	180/9376	2.0034188034188	CD74/HLA-DRA/HLA-DRB5/HLA-DPA1/POU2F2/HLA-DRB1/EIF4EBP1/SRSF5/HLA-DPB1/HLA-DMA/PIK3R1/CCL5/IRF3/BAD/HLA-DQB1	2.83174238307628
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/390	70/9376	2.74754578754579	HLA-DRA/HLA-DRB5/ITGB2/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1	3.05724887623658
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/390	203/9376	1.89485916382468	SPP1/COL1A1/COL6A2/HGF/COL1A2/COL6A1/ACTN1/IGF1/CCND2/TNXB/MYL9/LAMB2/PIK3R1/FLNA/PDGFRA/BAD	2.68523158325335
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/390	61/9376	2.7588062211013	FTL/FTH1/ATOX1/SLC40A1/HMOX1/ATP2B1/ATP1B3	2.87095387787771
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/390	160/9376	1.95333333333333	HLA-DRA/HLA-DRB5/ITGB2/HLA-DPA1/VCAN/HLA-DRB1/CD4/HLA-DPB1/HLA-DMA/PTPRC/GLG1/SIGLEC1/HLA-DQB1	2.53377630982318
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/390	52/9376	2.77396449704142	APOE/PLTP/APOC1/NPC2/LRP1/LRPAP1	2.67226914928517
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/390	68/9376	2.47481146304676	CD14/SPI1/CSF1R/EIF4EBP1/PIK3R1/FCGR1A/BAD	2.54271396434686
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/390	204/9376	1.76772247360483	COL1A1/HGF/DCN/COL1A2/GPC3/MMP2/ITPR2/CTSL/IGF1/HSPG2/PLAUR/PIK3R1/LUM/FLNA/PTPN6	2.30952171073104
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/390	137/9376	1.93030132884147	CTSS/CTSB/ITPR2/CTSL/CTSD/PARP1/CTSC/CTSZ/PIK3R1/CFLAR/BAD	2.28510508063405
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/390	89/9376	2.16099106885624	SPP1/COL1A1/COL6A2/COL1A2/COL6A1/TNXB/HSPG2/LAMB2	2.29256096767389
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/390	17/9376	4.24253393665158	NRP2/MYH10/MYH11	2.7875906668143
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/390	110/9376	1.96699300699301	TIMP1/LDHB/CYBB/IGF1/HMOX1/EIF4EBP1/ELOB/PIK3R1/LTBR	2.1252413765015
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/390	201/9376	1.6744992983799	CD14/SPI1/MAF/CSF1R/NUPR1/LYL1/IGF1/SPINT1/CCND2/FUS/BMP2K/TAF15/FCGR1A/MLLT1	2.01377631723159
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/390	112/9376	1.93186813186813	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/LAMB2/BAD/HLA-DQB1	2.0668022833138
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/390	205/9376	1.64182614133834	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/CCND2/PSMD7/NCOR2/HLA-DPB1/HLA-DMA/PIK3R1/IRF3/PSMD1/LYN/HLA-DQB1	1.93562276021032
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/390	116/9376	1.86525198938992	CYBA/ITGB2/CYBB/MMP2/ACTN1/MYL9/PIK3R1/NCF1/CXCR4	1.95344344528451
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/390	65/9376	2.21917159763314	SPP1/CGA/ITPR2/ARRB2/PIK3R1/ARRB1	2.05474572796856
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/390	50/9376	2.40410256410256	HGF/HBB/ITGB2/LRP1/GYPC	2.07381906939331
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/390	103/9376	1.8672641274583	COL3A1/COL1A1/COL6A2/COL1A2/COL6A1/COL14A1/ATP1B3/COL5A1	1.84371844349113
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/390	103/9376	1.8672641274583	COL3A1/COL1A1/CD14/COL1A2/ITGB2/ACTN1/LAMB2/PIK3R1	1.84371844349113
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/390	38/9376	2.5306342780027	ENPP1/QPRT/NNMT/NT5C	1.96956824262188
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/390	109/9376	1.76447894613032	HLA-DRA/HLA-DRB5/HLA-DPA1/HLA-DRB1/CD4/HLA-DPB1/HLA-DMA/HLA-DQB1	1.67241452752782
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/390	224/9376	1.5025641025641	HLA-DRA/SLC25A6/SPI1/HLA-DRB5/ITGB2/HLA-DPA1/HLA-DRB1/CD4/CCND2/HLA-DPB1/HLA-DMA/PIK3R1/LTBR/HLA-DQB1	1.58595990036524
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/390	59/9376	2.03737505432421	GSTP1/GPX3/GSTO1/IDH2/HPGDS	1.66516967425076
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/390	27/9376	2.67122507122507	FADS1/TECR/HSD17B12	1.81162781044769
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/390	78/9376	1.84930966469428	CD14/C1QA/C1QB/ITGB2/IRF3/C2	1.56910978672976
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/390	173/9376	1.52862012746406	HLA-DRA/SLC25A6/HLA-DRB5/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/PIK3R1/CCL5/IRF3/HLA-DQB1	1.46196430871587
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/390	193/9376	1.4947787963332	CXCL14/CCL3/CCL4/ARRB2/PIK3R1/NCF1/CCL5/CXCR4/ARRB1/BAD/WAS/LYN	1.44687887782183
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/390	98/9376	1.71721611721612	PIK3R1/NCF1/ARPC5/PTPRC/FCGR1A/WAS/LYN	1.48686188534737
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/390	80/9376	1.80307692307692	HGF/IGF1/EIF4EBP1/PIK3R1/PDGFRA/BAD	1.5027571982093
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/390	100/9376	1.6828717948718	CXCL14/CCL3/CSF1R/CCL4/CCL5/CXCR4/LTBR	1.43018935003154
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/390	46/9376	2.09052396878484	FTL/FTH1/BLVRB/HMOX1	1.54457159565935
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/390	46/9376	2.09052396878484	PSMA7/PSMD7/PSMB6/PSMD1	1.54457159565935
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/390	142/9376	1.5237269772481	TYROBP/CYBA/SPI1/CSF1R/ITPR2/PIK3R1/NCF1/FCGR1A/LILRB3	1.31005315300093
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/390	144/9376	1.5025641025641	SLC25A6/PSMA7/ITPR2/PSMD7/RB1CC1/PIK3R1/PSMB6/PSMD1/ATXN1	1.26607533172886
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/390	106/9376	1.58761490082245	GSTP1/FOLR2/IGF1/SPINT1/PIK3R1/PDGFRA/BAD	1.26747849734997
Organismal Systems	Immune system	hsa04611	Platelet activation	8/390	126/9376	1.52641432641433	COL3A1/COL1A1/FCER1G/COL1A2/VAMP8/ITPR2/PIK3R1/LYN	1.23930111635107
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/390	169/9376	1.42254589591868	RPS27A/UBA52/VAMP8/CTSB/CTSL/CTSD/RB1CC1/PIK3R1/CFLAR/BAD	1.15476311452842
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/390	34/9376	2.12126696832579	POLR2L/POLR2I/POLR2G	1.36446779607077
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/390	109/9376	1.54391907786403	SPP1/CD14/CCL3/CCL4/PIK3R1/CCL5/IRF3	1.18990610823737
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/390	232/9376	1.34712643678161	ITGB2/ACTN1/IQGAP2/C7/MYL9/MYH10/PIK3R1/PDGFRA/ARPC5/CXCR4/ENAH/NCKAP1L/MYH11	1.11531696603898
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/390	130/9376	1.47944773175542	COL3A1/COL1A1/COL1A2/MMP2/ACTA2/ARRB2/PIK3R1/ARRB1	1.14675524329774
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/390	362/9376	1.26182178778864	CSH1/SPP1/COL1A1/COL6A2/HGF/COL1A2/COL6A1/CSF1R/CSH2/CSF3R/IGF1/CCND2/TNXB/PRLR/EIF4EBP1/LAMB2/PIK3R1/PDGFRA/BAD	1.0583663589663
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/390	53/9376	1.81441702951137	AP2S1/ATP2B1/ATP1B3/CLTB	1.23863022514141
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/390	73/9376	1.64664559185107	HGF/IGF1/PIK3R1/PDGFRA/BAD	1.1554495173988
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/390	36/9376	2.0034188034188	AKR1B1/AKR1A1/DCXR	1.25659342220911
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/390	216/9376	1.33561253561254	CYBA/CD14/CCL3/CYBB/POU2F2/OLR1/PIK3R1/NCF1/CCL5/IRF3/BAD/LYN	1.03956595276402
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/390	134/9376	1.43528511289705	ITPR2/PLA2G2A/CALD1/MYL9/ACTA2/MYH10/RAMP3/MYH11	1.05725066227014
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/390	38/9376	1.89797570850202	IGF1/ATP1B3/PIK3R1	1.15548466640857
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/390	138/9376	1.39368264585656	RHOG/CD4/FYB1/PIK3R1/ARPC5/IRF3/WAS/SKAP2	0.970580517966761
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/390	21/9376	2.28962148962149	ENPP1/PPCS	1.23249381182872
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/390	142/9376	1.35442397977609	GSTP1/CYBA/MMP2/CTSL/HMOX1/GSTO1/PIK3R1/NCF1	0.886557829509798
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/390	101/9376	1.42817974105103	COL3A1/COL1A1/COL1A2/CYBB/MMP2/PIK3R1	0.901290051900559
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/390	103/9376	1.40044809559373	C1QA/C1QB/CCL3/PIK3R1/CCL5/CFLAR	0.851313361329536
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/390	105/9376	1.37377289377289	CD14/CCL4/PARP1/CFLAR/LTBR/LYN	0.802368548032453
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/390	105/9376	1.37377289377289	RPS27A/UBA52/VCP/FIS1/USP8/MTX1	0.802368548032453
NA	NA	hsa04382	Cornified envelope formation	11/390	217/9376	1.21866950254047	S100A6/KRT18/S100A11/S100A9/KRT8/KRT7/S100A4/PLEC/DSP/S100A13/S100A8	0.678935924301835
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/390	195/9376	1.23287310979619	CYBA/SLC25A6/ITGB2/CYBB/C5AR1/HDAC7/PIK3R1/FPR1/NCF1/FCGR1A	0.684583439967007
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/390	47/9376	1.53453355155483	LDHB/ACSS1/AKR1A1	0.765316518468323
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/390	69/9376	1.39368264585656	FCER1G/ALOX5AP/PIK3R1/LYN	0.683755281306313
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/390	28/9376	1.71721611721612	TECR/HSD17B12	0.791779838372903
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/390	70/9376	1.37377289377289	HGF/ELOB/PIK3R1/BAD	0.653898036662992
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/390	71/9376	1.35442397977609	CGA/CCND2/PRLR/PIK3R1	0.624494787975929
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/390	71/9376	1.35442397977609	ATP6V0B/ATP6V0D1/CCL5/LYN	0.624494787975929
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/390	71/9376	1.35442397977609	LDHB/IDH2/PIK3R1/PDGFRA	0.624494787975929
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/390	93/9376	1.2925282602702	ACTN1/MYL9/LMO7/PTPN6/WAS	0.590608729750377
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/390	93/9376	1.2925282602702	CST3/LYZ/ITPR2/ATP2B1/ATP1B3	0.590608729750377
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/390	115/9376	1.2543143812709	ITPR2/AKAP13/MAFB/NR4A2/ARRB2/ARRB1	0.571643977691135
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/390	205/9376	1.17273295809881	ACTN1/CCND2/CHD4/ATP6V0D1/HDAC7/PIK3R1/IRF3/LTBR/BAD/LYN	0.520928992448543
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/390	117/9376	1.23287310979619	CHD4/BPTF/ZNHIT1/BRD9/CHD3/RBBP7	0.528037743161848
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/390	73/9376	1.31731647348086	CD4/CXCR4/NELFE/MLLT1	0.566992446506289
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/390	73/9376	1.31731647348086	HGF/EML4/PIK3R1/BAD	0.566992446506289
NA	NA	hsa04517	IgSF CAM signaling	14/390	299/9376	1.12566675242261	ITGB2/NRP2/ACTN1/CD84/MYL9/MYH10/PIK3R1/ARPC5/PMP22/MYH11/LMO7/PTPN6/LYN/EPB41L3	0.460065379064892
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/390	52/9376	1.38698224852071	CGA/HSD17B1/IGF1	0.582943303413108
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/390	31/9376	1.55103391232423	TKT/PGLS	0.640183175160099
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/390	31/9376	1.55103391232423	ACSS1/GLUL	0.640183175160099
NA	NA	hsa04981	Folate transport and metabolism	2/390	31/9376	1.55103391232423	FOLR2/SLCO2B1	0.640183175160099
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/390	75/9376	1.28218803418803	GSTP1/GSTO1/PIK3R1/BAD	0.511139140347519
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/390	75/9376	1.28218803418803	CGA/GPX3/ITPR2/ATP1B3	0.511139140347519
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/390	32/9376	1.5025641025641	LDHB/ACSS1	0.593245937915501
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/390	99/9376	1.21419321419321	MMP2/IGF1/PIK3R1/JAG2/BAD	0.446328132297223
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/390	168/9376	1.14481074481074	FTL/FTH1/SLC25A6/CYBB/PARP1/CHMP2A/GLUL/CFLAR	0.394554960074096
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/390	168/9376	1.14481074481074	CSH1/CSH2/CSF3R/CCND2/PRLR/PIK3R1/PDGFRA/PTPN6	0.394554960074096
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/390	78/9376	1.23287310979619	LSM3/LSM7/DHX36/LSM2	0.430235861944326
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/390	78/9376	1.23287310979619	RHOG/PIK3R1/ARPC5/CLTB	0.430235861944326
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	15/390	333/9376	1.08292908292908	SPP1/COL1A1/COL6A2/COL1A2/COL6A1/ATP6V0B/CCND2/TNXB/EIF4EBP1/CHD4/ATP6V0D1/LAMB2/PIK3R1/IRF3/BAD	0.321001785947693
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/390	56/9376	1.28791208791209	CCND2/ARRB2/ARRB1	0.450174292717389
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/390	56/9376	1.28791208791209	CD14/ITGB2/VCP	0.450174292717389
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/390	79/9376	1.21726712106459	AP2S1/ATP6V0B/ATP6V0D1/CLTB	0.403990241244648
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/390	57/9376	1.26531713900135	FADS1/TECR/HSD17B12	0.418555267687308
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/390	243/9376	1.08827688086947	PRPF38B/RBM25/SNRPD2/LSM3/LSM7/FUS/SRSF5/U2SURP/LSM2/TCERG1/SNRNP70	0.290454508566039
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/390	59/9376	1.22242503259452	ENPP1/NME4/NT5C	0.357031352861977
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/390	83/9376	1.15860364535063	CCL4/POLR2L/CCL5/IRF3	0.302349306730216
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/390	248/9376	1.06633581472291	CD14/RHOG/RPS3/CYTH4/MYL9/FLNA/ARPC5/PTPRC/NCKAP1L/ANXA2/DCTN3	0.220556990259196
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/390	60/9376	1.20205128205128	ITPR2/IGF1/LYN	0.327082441073721
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/390	298/9376	1.04876957494407	CSH1/CXCL14/CCL3/CSF1R/CSH2/CSF3R/CCL4/CD4/PRLR/CCL5/IL1RN/CXCR4/LTBR	0.178236542059065
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	10/390	227/9376	1.05907601942844	CCL3/CCL4/ITPR2/AKAP13/EIF4EBP1/PIK3R1/PDGFRA/CCL5/CXCR4/IRF3	0.18770337176245
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/390	38/9376	1.26531713900135	CD4/PTPRC	0.341401090195258
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/390	85/9376	1.13134238310709	ENPP1/GUK1/NME4/NT5C	0.253406563491192
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/390	133/9376	1.08455754771544	TYROBP/FCER1G/ITGB2/HCST/PIK3R1/PTPN6	0.204600390324301
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/390	62/9376	1.16327543424318	NCOR2/JAG2/ATXN1	0.268709678926404
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/390	253/9376	1.04526198439242	RPS27A/UBA52/CD14/ITPR2/ACTN1/CYTH4/MYL9/PIK3R1/ARPC5/CCL5/IRF3	0.152040660731866
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/390	63/9376	1.14481074481074	PTGDS/PLA2G2A/HPGDS	0.240248671647807
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/390	63/9376	1.14481074481074	POLR2L/POLR2I/POLR2G	0.240248671647807
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/390	17/9376	1.41417797888386	GLUL	0.35606679556573
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/390	90/9376	1.06849002849003	IGF1/EIF4EBP1/RB1CC1/PIK3R1	0.136009422472832
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/390	90/9376	1.06849002849003	CD4/EML4/PIK3R1/PTPN6	0.136009422472832
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/390	212/9376	1.02060957910015	HGF/CSF1R/ITGB2/IGF1/FYB1/PIK3R1/FPR1/PDGFRA/ENAH	0.0632308830902942
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/390	91/9376	1.0567483798253	PIK3R1/PTPN6/LILRB3/LYN	0.113322968817656
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/390	67/9376	1.07646383467279	LDHB/ACSS1/AKR1A1	0.130850894232369
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/390	166/9376	1.0137781896818	SLC25A6/ITPR2/ATP2B1/MYL9/ATP1B3/BAD/RGS2	0.0373122228679869
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/390	44/9376	1.09277389277389	TAF15/TAF3	0.128498922989963
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/390	19/9376	1.26531713900135	HGSNAT	0.241161805062653
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/390	144/9376	1.0017094017094	CD14/C1QA/C1QB/C5AR1/IRF3/C2	0.00430637867934984
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/390	194/9376	0.991382500660851	TPM1/MYO1F/MYL9/ACTA2/MYH10/MYH11/DCTN3/MYO9B	-0.0252666819791487
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/390	70/9376	1.03032967032967	GSTP1/GSTO1/HPGDS	0.0530603267695961
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/390	122/9376	0.985287936107608	CSH1/CSH2/ITPR2/IGF1/PIK3R1	-0.0340740302524268
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/390	98/9376	0.981266352694924	ITPR2/ATP2B1/ATP1B3/NR4A2	-0.0388367543378345
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/390	73/9376	0.987987355110643	GSTP1/GSTO1/HPGDS	-0.0214646243862243
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/390	99/9376	0.971354571354571	EIF4EBP1/PIK3R1/PDGFRA/WAS	-0.0596903161210074
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	8/390	200/9376	0.961641025641026	RPS3/CYTH4/MYO1F/MYH10/ARPC5/NCKAP1L/MYH11/PTPN6	-0.114232588103524
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/390	300/9376	0.961641025641026	HGF/CD14/CSF1R/IGF1/DUSP9/TAOK3/ARRB2/FLNA/PDGFRA/ARRB1/MAP3K20/MAP4K4	-0.140674410802252
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/390	48/9376	1.0017094017094	ATP1B3/PIK3R1	0.00247346186236113
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/390	22/9376	1.09277389277389	AOC1	0.0907555456207829
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/390	75/9376	0.961641025641026	TKT/IDH2/GLUL	-0.0694812352156429
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/390	76/9376	0.948987854251012	PLTP/OLR1/PLIN2	-0.0930194245106889
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/390	76/9376	0.948987854251012	IGF1/PIK3R1/PDGFRA	-0.0930194245106889
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/390	102/9376	0.942785319255907	ITPR2/PLA2G2A/ATP2B1/ATP1B3	-0.121034381050905
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/390	50/9376	0.961641025641026	SAT1/AOC1	-0.0566551009461721
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/390	23/9376	1.04526198439242	GLUL	0.0452748245449983
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/390	23/9376	1.04526198439242	CTSA	0.0452748245449983
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/390	23/9376	1.04526198439242	ATP1B3	0.0452748245449983
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/390	51/9376	0.942785319255907	PLA2G2A/PLD3	-0.085349873413429
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/390	51/9376	0.942785319255907	ATP6V0B/ATP6V0D1	-0.085349873413429
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/390	105/9376	0.915848595848596	FCER1G/LSP1/ITPR2/PIK3R1	-0.180645630244338
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/390	157/9376	0.918765311121999	C1QA/STAB1/C1QB/LRP1/MFGE8/PTPN6	-0.213837650870115
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/390	79/9376	0.912950340798442	GSTP1/GSTO1/HPGDS	-0.161861641323297
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/390	54/9376	0.890408357075024	LDHB/MRI1	-0.168249779151698
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/390	187/9376	0.899931441107912	CYBA/CYBB/CTSB/ITPR2/CCL5/IRF3/GPSM3	-0.287951309280102
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/390	26/9376	0.92465483234714	PLA2G2A	-0.0801439985913648
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/390	26/9376	0.92465483234714	SLC19A3	-0.0801439985913648
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/390	82/9376	0.879549718574109	GSTP1/GSTO1/NME4	-0.228217080738305
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/390	136/9376	0.883861236802413	RACK1/CCND2/PIK3R1/IRF3/BAD	-0.284213956183516
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/390	139/9376	0.864785095000922	KRT18/MMP2/ITPR2/CTSD/PIK3R1	-0.334580965646267
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/390	28/9376	0.858608058608059	AKR1B1	-0.156091428811001
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/390	28/9376	0.858608058608059	ATP6V0D1	-0.156091428811001
NA	NA	hsa04081	Hormone signaling	8/390	219/9376	0.878210982320571	CSH1/CGA/CSH2/IGF1/SLC40A1/PRLR/PIK3R1/RAMP3	-0.37991663721173
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/390	86/9376	0.838640429338104	EIF4EBP1/PIK3R1/BAD	-0.313163279818521
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/390	29/9376	0.829000884173298	RASSF4	-0.192128360601983
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/390	59/9376	0.814950021729683	CGA/PIK3R1	-0.297037807832415
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/390	59/9376	0.814950021729683	PIK3R1/BAD	-0.297037807832415
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/390	170/9376	0.848506787330317	ACTN1/MYL9/MYH10/ARPC5/MYH11/WAS	-0.415256926882427
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/390	170/9376	0.848506787330317	GSTP1/HGF/HMOX1/GSTO1/PIK3R1/BAD	-0.415256926882427
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/390	116/9376	0.829000884173298	TKT/ACSS1/IDH2/PGLS	-0.386057594847766
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/390	60/9376	0.801367521367521	PIK3R1/BAD	-0.321548051207838
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/390	30/9376	0.801367521367521	IDH2	-0.227003595266656
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/390	30/9376	0.801367521367521	PLA2G2A	-0.227003595266656
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/390	30/9376	0.801367521367521	FOLR2	-0.227003595266656
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/390	144/9376	0.834757834757835	ZFHX3/IGF1/DUSP9/PIK3R1/REST	-0.416283272337154
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/390	31/9376	0.775516956162117	AKR1A1	-0.260801131399656
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/390	62/9376	0.775516956162117	IGF1/PIK3R1	-0.369441777409453
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/390	32/9376	0.751282051282051	AKR1B1	-0.293596203968386
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/390	93/9376	0.775516956162117	CGA/MMP2/ITPR2	-0.453226793367349
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/390	122/9376	0.788230348886087	CD4/PIK3R1/PTPRC/PTPN6	-0.490471326890647
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/390	33/9376	0.728515928515929	IDH2	-0.325456450668575
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/390	33/9376	0.728515928515929	VAMP8	-0.325456450668575
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/390	65/9376	0.739723865877712	AKR1B1/AKR1A1	-0.438659558439674
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/390	66/9376	0.728515928515929	HSD17B1/HSD17B12	-0.461079926871293
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/390	35/9376	0.686886446886447	AKR1B1	-0.386610760174244
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/390	36/9376	0.667806267806268	ENPP1	-0.416010201673997
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/390	128/9376	0.751282051282051	ENPP1/GUK1/NME4/NT5C	-0.590232250898094
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/390	99/9376	0.728515928515929	ITPR2/IGF1/PIK3R1	-0.565708764539238
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/390	99/9376	0.728515928515929	IGF1/TPM1/DES	-0.565708764539238
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/390	157/9376	0.765637759268333	SLC25A6/ITPR2/CCND2/EIF4EBP1/PIK3R1	-0.616922052671119
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/390	69/9376	0.696841322928279	CTSB/ITPR2	-0.526531582489796
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/390	158/9376	0.760791950665368	LAMTOR4/CLIP1/IGF1/EIF4EBP1/PIK3R1	-0.631714311142102
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/390	37/9376	0.64975744975745	GLUL	-0.444686879132878
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/390	37/9376	0.64975744975745	HBB	-0.444686879132878
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/390	214/9376	0.786388689192427	ITPR2/CD4/ELOB/PIK3R1/CXCR4/IRF3/BAD	-0.658522658171985
NA	NA	hsa04519	Cadherin signaling	14/390	404/9376	0.833104848946433	KRT18/KRT8/KRT7/ACTN1/MYO1F/TAOK3/LIMA1/DSP/PDGFRA/DAAM1/ARPC5/ENAH/NCKAP1L/DES	-0.714372131089262
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/390	105/9376	0.686886446886447	IGF1/TPM1/DES	-0.672152719382733
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/390	75/9376	0.641094017094017	IGF1/CCND2	-0.650101610778805
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/390	41/9376	0.586366479049406	MMP2	-0.552949193083334
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/390	76/9376	0.632658569500675	ITPR2/ATP1B3	-0.66983828973041
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/390	196/9376	0.735949764521193	RPS27A/UBA52/ITPR2/PIK3R1/IRF3/LYN	-0.778265876151562
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/390	138/9376	0.696841322928279	EIF4EBP1/FLOT1/PIK3R1/BAD	-0.747403800790338
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/390	42/9376	0.572405372405372	AOC1	-0.578572412137011
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/390	226/9376	0.744633537553892	CGA/ATP2B1/MYL9/ATP1B3/PIK3R1/FXYD1/BAD	-0.809547372264892
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/390	77/9376	0.624442224442224	PIK3R1/BAD	-0.689348335640948
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/390	77/9376	0.624442224442224	PIK3R1/BAD	-0.689348335640948
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/390	43/9376	0.559093619558736	PLA2G2A	-0.603677116031614
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/390	110/9376	0.655664335664336	DCN/EMP3/FBN1	-0.756775277545081
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/390	44/9376	0.546386946386946	PARP1	-0.628288703865496
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/390	44/9376	0.546386946386946	ARHGDIB	-0.628288703865496
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/390	47/9376	0.511511183851609	PIK3R1	-0.699392131696812
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/390	83/9376	0.579301822675317	PRDX5/IDH2	-0.801985364053776
NA	NA	hsa03272	Virion - Hepatitis viruses	1/390	48/9376	0.500854700854701	HSPG2	-0.72225086380944
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/390	238/9376	0.707088989441931	HGF/CSF1R/PLA2G2A/IGF1/PIK3R1/PDGFRA/BAD	-0.953527743013624
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/390	149/9376	0.645396661504044	FCER1G/CYTH4/PIK3R1/PDGFRA	-0.908950909498987
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/390	119/9376	0.606076276664512	PIK3R1/CCL5/CFLAR	-0.900917907810112
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/390	86/9376	0.559093619558736	DSP/DES	-0.855701881366646
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/390	120/9376	0.601025641025641	ARHGDIB/PIK3R1/BAD	-0.91634427370937
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/390	87/9376	0.552667256115532	PIK3R1/BAD	-0.873253969175137
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/390	184/9376	0.653288740245262	SEMA6A/MYL9/PIK3R1/CXCR4/ENAH	-0.989479006264665
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/390	122/9376	0.591172761664565	IGF1/EIF4EBP1/PIK3R1	-0.946868623528867
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/390	122/9376	0.591172761664565	ATP1B3/PIK3R1/BAD	-0.946868623528867
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/390	154/9376	0.624442224442224	NME4/QPRT/PPCS/AKR1A1	-0.978947257630281
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/390	89/9376	0.540247767214059	ITPR2/PDGFRA	-0.907853688077322
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/390	217/9376	0.664728819567529	EIF4EBP1/GSTO1/ARRB2/PIK3R1/ARRB1/BAD	-1.04096660089378
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/390	156/9376	0.616436554898093	PIK3R1/IRF3/CFLAR/BAD	-1.00639572655876
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/390	91/9376	0.528374189912652	ARRB2/ARRB1	-0.941807275109196
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/390	125/9376	0.576984615384615	FCER1G/CTSD/PIK3R1	-0.991862710531582
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/390	93/9376	0.517011304108078	LAMB2/PIK3R1	-0.975144554926212
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/390	94/9376	0.511511183851609	S100A9/S100A8	-0.991590835862363
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/390	163/9376	0.589963819411672	HSPG2/PIK3R1/IRF3/BAD	-1.10014563684809
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/390	98/9376	0.490633176347462	ITPR2/PIK3R1	-1.05596918079464
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/390	133/9376	0.542278773857721	IGF1/CCND2/PIK3R1	-1.10752906226164
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/390	133/9376	0.542278773857721	ITPR2/ARRB2/ARRB1	-1.10752906226164
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/390	63/9376	0.381603581603582	ASH1L	-1.02595230944822
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/390	104/9376	0.46232741617357	PLA2G2A/PLD3	-1.14863642664648
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/390	140/9376	0.515164835164835	SPP1/ITPR2/ACTA2	-1.2040676874299
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/390	65/9376	0.369861932938856	ITPR2	-1.06201088004173
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/390	142/9376	0.507908992416035	RPS27A/UBA52/ELOB	-1.23091878794584
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/390	107/9376	0.449364965252816	LDHB/ITPR2	-1.19336699600199
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/390	67/9376	0.358821278224263	ITPR2	-1.09723517616072
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/390	109/9376	0.441119736532581	OGA/PIK3R1	-1.22263598821484
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/390	110/9376	0.437109557109557	IGF1/PIK3R1	-1.23711138655284
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/390	148/9376	0.487318087318087	IGF1/PIK3R1/JAG2	-1.30966371483535
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/390	72/9376	0.333903133903134	IRF3	-1.18196202196089
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/390	115/9376	0.418104793756968	ITPR2/PIK3R1	-1.3079751472719
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/390	254/9376	0.567898243488795	HGF/SLC25A6/ITPR2/ATP2B1/PDGFRA/CXCR4	-1.45442921861229
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/390	116/9376	0.414500442086649	ITPR2/GLUL	-1.32185801090068
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/390	154/9376	0.468331668331668	TPM1/ATP2B1/ATP1B3	-1.38587266495168
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/390	154/9376	0.468331668331668	ITPR2/MYL9/RGS2	-1.38587266495168
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/390	78/9376	0.308218277449047	ISYNA1	-1.27807502523382
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/390	83/9376	0.289650911337658	RBBP7	-1.35415269944577
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/390	86/9376	0.279546809779368	ATP1B3	-1.39824048291477
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/390	89/9376	0.27012388360703	GLUL	-1.44125613070252
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/390	174/9376	0.414500442086649	SSR4/UBXN1/VCP	-1.62403287280997
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/390	90/9376	0.267122507122507	ATP1B3	-1.45536871201794
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/390	138/9376	0.34842066146414	ITPR2/IGF1	-1.60639596016889
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/390	178/9376	0.405185825410544	SERPINF1/CCND2/DAAM1	-1.66908841386518
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/390	323/9376	0.521012939588791	CCND2/TNXB/HMOX1/TPM1/ZEB2/PIK3R1/PDGFRA	-1.8250027234748
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/390	150/9376	0.320547008547009	HGF/PIK3R1	-1.74756385684523
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/390	103/9376	0.233408015932288	FUS	-1.62969934407446
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/390	155/9376	0.310206782464847	ITPR2/USP8	-1.80397490775903
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/390	157/9376	0.306255103707333	ITGB2/CCND2	-1.82617525807413
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/390	158/9376	0.304316780266147	ATRX/CCND2	-1.83720007395113
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/390	115/9376	0.209052396878484	ITPR2	-1.77787992851265
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/390	370/9376	0.38985446985447	CSH1/CGA/CSH2/C5AR1/PRLR/FPR1	-2.49461229986775
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/390	191/9376	0.125869244193852	HDAC7	-2.54265969459211
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/390	449/9376	0.160630460853178	ARRB2/ARRB1/RGS2	-3.79715514713052