category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	101/2614	174/9376	2.08201637513302	OSTC/HSPA1B/BAG2/HSPA5/HSPA1A/HERPUD1/HSPA8/SEC61B/HSPH1/SSR3/DNAJA1/ERN1/DNAJB11/PDIA6/EDEM2/UBQLN2/SEC24D/CALR/EIF2AK3/SKP1/EDEM3/DAD1/STT3B/DERL2/DDOST/SAR1B/SEC24A/MAPK10/SEC23B/UBE2D1/AMFR/UBXN8/PDIA3/SEC23A/SSR2/SEC61G/MAN1A1/CAPN2/SYVN1/HYOU1/EIF2S1/DERL1/UBE2J2/TRAM1/UFD1/MAPK8/MAN1C1/BCL2/RAD23B/ERO1B/SEC13/UBE2G1/BCAP29/PDIA4/PREB/DNAJA2/UGGT2/DNAJC3/YOD1/HSP90AB1/EDEM1/CANX/ATF6B/UBE2J1/XBP1/MAPK9/BAX/DDIT3/SEC24C/UGGT1/MBTPS1/PLAA/STT3A/SEC24B/CUL1/RNF5/DNAJC10/UBE2G2/ERO1A/RPN1/MOGS/FBXO6/DNAJB12/RAD23A/HSP90AA1/MBTPS2/TRAF2/TUSC3/UBQLN1/HSPA4L/UBE2D3/RBX1/SAR1A/HSPA1L/TXNDC5/LMAN2/P4HB/PPP1R15A/BAK1/MAP3K5/VCP	8.95711581545532
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	78/2614	142/9376	1.97023610677069	UBE2N/SIAH1/SOCS3/CUL3/CDC26/SOCS1/SKP1/HERC4/CUL2/UBA2/UBE2S/UBE2B/FANCL/UBA3/UBE2A/UBA6/UBE2H/UBE2D1/ELOC/UBE2E3/COP1/UBE2Z/UBE2I/RCHY1/SYVN1/UBE2J2/ANAPC7/UBE2W/UBE2L6/ANAPC10/UBE2F/UBE2M/CUL4B/CDC27/UBE2E1/UBE2G1/UBE2Q1/KLHL9/RNF7/KLHL13/UBE2J1/ANAPC13/PIAS2/MDM2/NEDD4/PPIL2/CUL4A/BIRC6/FBXO4/CDC23/SKP2/CDC16/UBE3A/SAE1/CUL1/UBE2Q2/UBE3C/UBE2G2/KEAP1/TRAF6/HERC2/ANAPC4/BTRC/SMURF2/VHL/UBE2D3/TRIM32/TRIP12/RBX1/CBLB/ERCC8/DET1/UBE2L3/PIAS3/CUL5/RHOBTB1/UBC/NHLRC1	7.24315061880595
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	160/2614	388/9376	1.47910931621168	SDHD/FAS/NDUFB5/PSMA2/PSMA3/NDUFB3/WNT2/MME/ERN1/PSMA5/SLC39A14/TNFRSF1A/PPID/AKT1/NDUFC2/DKK1/EIF2AK3/CSF1/CTNNB1/ADAM17/CASP3/NAE1/PSMD11/PSMB2/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/FZD2/TUBA3D/ATP5F1C/SDHC/PIK3CA/CASP7/SLC39A1/NDUFA9/COX7A2L/PSMB3/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/ATP2A2/PSMD12/NRBF2/NDUFB6/IL6/CAPN2/CYCS/EIF2S1/UQCRFS1/NFKB1/WIPI1/CASP8/PSMB5/NDUFA8/PSMC4/PPP3CC/MAPK1/ATG101/PSMC6/MAPK8/VDAC3/UQCRH/BID/PSMC2/VDAC2/PLCB3/NDUFS4/MAP2K2/NDUFA7/PSMA1/PSMD6/IDE/FZD1/PPIF/PPP3R1/MCU/APH1B/PIK3C3/HSD17B10/NDUFS3/TUBB2A/PSMD9/RAF1/FZD8/NCSTN/SLC11A2/RTN3/LRP1/GSK3B/ATP5MC1/XBP1/NRAS/PPP3CB/VDAC1/MAPK9/IL1A/MAP2K1/ATP5PB/DDIT3/CSNK2A2/FADD/CACNA1C/PIK3R4/WNT6/KRAS/CACNA1D/CSNK2B/SLC39A6/ATG2B/PIK3R3/SLC39A3/DVL3/AKT3/BRAF/ATP5PO/NDUFA10/PSMB4/NDUFB4/PSMA4/PSENEN/CASP9/LRP6/BECN1/CHUK/ADAM10/NDUFA5/DVL2/PSEN1/TUBA1A/TRAF2/CALM2/EIF2AK2/TUBB6/PSMA6/TUBB2B/ITPR3/SLC39A13/PSMB1/CYC1/CSNK1A1/KIF5A/IRS1/NDUFA12/ATP5MC2/COX6C/WIPI2/FRAT2/COX8A/FZD10/PSMB7/MAP3K5/COX6A1/SLC39A8/PSMB6/COX5A/COX7B/TNF	5.99266213924121
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	153/2614	368/9376	1.49126775556369	SDHD/NDUFB5/PSMA2/HSPA5/PSMA3/NDUFB3/ACTG1/SRSF7/NXT1/TBK1/ERN1/PSMA5/CAT/UBQLN2/NUP54/TNFRSF1A/NDUFC2/EIF2AK3/ACTR10/NUP153/HNRNPA2B1/TANK/CASP3/PSMD11/PSMB2/NDUFV2/SDHB/NDUFA4/TUBA3D/ATP5F1C/SDHC/NUP58/NDUFA9/NUP160/NUP98/ANXA7/COX7A2L/HNRNPA3/PSMB3/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/ATXN2L/WDR41/PSMD12/NRBF2/MAP2K3/DCTN6/NDUFB6/SETX/PFN2/SPG11/NUP205/CYCS/EIF2S1/DERL1/UQCRFS1/WIPI1/NXF1/PSMB5/NDUFA8/ALYREF/PSMC4/PPP3CC/ATG101/NUP37/PSMC6/GPX8/UQCRH/BCL2/BID/PSMC2/NDUFS4/C9orf72/NDUFA7/PSMA1/PSMD6/PPP3R1/MCU/SEC13/PIK3C3/NCBP1/MAP1LC3B/NDUFS3/NUP35/HNRNPA1/TUBB2A/PSMD9/CASP1/ATP5MC1/NUP155/XBP1/PPP3CB/VDAC1/RAB8A/BAX/ACTR1B/NXT2/ATP5PB/DDIT3/RAE1/PIK3R4/NUP133/DNAH11/TOMM40/ATG2B/NUP50/NUP107/ATP5PO/CHMP2B/NDUFA10/PSMB4/NDUFB4/PSMA4/DNAH14/RAB1A/CASP9/TP53/SEH1L/BECN1/NDUFA5/DNAL4/TUBA1A/TRAF2/TUBB6/PSMA6/TUBB2B/ITPR3/UBQLN1/PFN1/PSMB1/NUP43/CYC1/ALS2/KIF5A/NDUFA12/ATP5MC2/MAPK12/COX6C/WIPI2/MAPK14/COX8A/NEFM/PSMB7/MAP3K5/VCP/COX6A1/PSMB6/COX5A/DNAH7/COX7B/TNF	5.97762721218412
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	58/2614	108/9376	1.92626597523308	DDX39B/EIF4A3/NXT1/SUMO1/NUP54/RAN/NUP153/KPNA2/SUMO2/NUP58/NUP160/NUP98/XPOT/THOC1/RANBP17/MAGOHB/MAGOH/UBE2I/NUP205/THOC6/NXF1/ALYREF/NUP37/XPO5/AHCTF1/TMEM33/SEC13/RNPS1/NCBP1/NUP35/THOC7/TNPO1/PYM1/NUP155/XPO1/SUMO4/XPO4/NXT2/RAE1/KPNA4/IPO4/IPO5/THOC3/NUP133/IPO11/IPO7/EEF1A1/NMD3/NUP50/NUP107/SEH1L/XPO7/THOC5/NUP43/TNPO2/KPNA5/NCBP2/SAP18	6.01943075787985
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	187/2614	480/9376	1.39737311910227	SDHD/SNCAIP/FAS/NDUFB5/PSMA2/HSPA5/PSMA3/NDUFB3/WNT2/IFT57/TBK1/ERN1/PSMA5/CAT/TNFRSF1A/PPID/NDUFC2/DKK1/EIF2AK3/ACTR10/TANK/CSF1/CTNNB1/CASP3/PSMD11/PSMB2/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/FZD2/TUBA3D/ATP5F1C/SDHC/CASP7/NDUFA9/COX7A2L/PSMB3/ATP5MC3/NDUFB8/PRKCA/NDUFAB1/UQCRC2/ATXN2L/WDR41/ATP2A2/PSMD12/NRBF2/MAP2K3/DCTN6/NDUFB6/CAMK2D/IL6/PRNP/SPG11/CAPN2/CYCS/MFN1/EIF2S1/DERL1/UQCRFS1/NFKB1/WIPI1/CASP8/PSMB5/NDUFA8/UBE2J2/PSMC4/PPP3CC/HTRA2/MAPK1/ATG101/PSMC6/MAPK8/GPX8/VDAC3/UQCRH/BCL2/BID/PSMC2/VDAC2/PLCB3/UBE2L6/NDUFS4/C9orf72/MAP2K2/NDUFA7/PSMA1/PSMD6/FZD1/GRIA4/PPIF/PPP3R1/MCU/UBE2G1/PIK3C3/HSD17B10/MAP1LC3B/NDUFS3/TUBB2A/PSMD9/RAF1/FZD8/GSK3B/UBE2J1/ATP5MC1/XBP1/NRAS/PPP3CB/VDAC1/MAPK9/IL1A/RAB8A/BAX/ACTR1B/MAP2K1/ATP5PB/DDIT3/CSNK2A2/FADD/CACNA1C/PIK3R4/WNT6/KRAS/CACNA1D/CSNK2B/DNAH11/TOMM40/ATG2B/UBE2G2/UCHL1/DVL3/BRAF/ATP5PO/CHMP2B/NDUFA10/PSMB4/NDUFB4/PSMA4/DNAH14/RAB1A/CASP9/LRP6/BECN1/ATXN1/NDUFA5/DVL2/DNAL4/PSEN1/TUBA1A/TRAF2/CALM2/TUBB6/PSMA6/TUBB2B/ITPR3/PSMB1/DLG4/CYC1/ALS2/CSNK1A1/KIF5A/ATXN1L/PARK7/UBE2L3/NDUFA12/ATP5MC2/MAPK12/COX6C/WIPI2/MAPK14/FRAT2/COX8A/FZD10/NEFM/PSMB7/BAK1/MAP3K5/VCP/UBC/COX6A1/PSMB6/COX5A/DNAH7/COX7B/TNF	5.55677181879674
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	75/2614	157/9376	1.71345864258598	MYC/GADD45A/HLA-F/CHEK2/PPID/PTEN/AKT1/ZFP36L1/CCND2/PPP1CB/PPP1CC/SLC25A5/PIK3CA/RAD50/CXCL8/SERPINE1/ATR/TRAF3IP2/NBN/E2F4/MAP2K3/IL6/MAPKAPK2/CAPN2/CHEK1/SIRT1/RHEB/HIPK3/NFKB1/HIPK1/PPP3CC/ZFP36L2/MAPK1/VDAC3/VDAC2/NFATC1/MAP2K2/ATM/PPP3R1/MCU/CDK4/RAD1/RAF1/TRPM7/MDM2/HUS1/NRAS/PPP3CB/VDAC1/IL1A/MAP2K1/RBL2/HLA-B/KRAS/CACNA1D/GADD45B/PIK3R3/RB1/AKT3/TSC1/BTRC/GADD45G/CDKN2B/TP53/CALM2/E2F5/ITPR3/RRAS/MAPK12/MAPK14/CCNB1/E2F3/LIN9/TGFB3/CDK2	5.60502518748493
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	43/2614	75/9376	2.05645498597297	FAS/GADD45A/SIAH1/CHEK2/PTEN/CCND2/RPRM/CASP3/SERPINE1/ATR/GORAB/MDM4/COP1/RCHY1/CHEK1/CYCS/CASP8/BCL2/BID/ATM/CDK4/CCNG1/MDM2/BAX/SESN3/PMAIP1/RRM2B/PERP/SESN1/GADD45B/CCNG2/TNFRSF10B/GADD45G/CASP9/TP53/BBC3/PIDD1/PPM1D/THBS1/CCNB1/TP53I3/ZMAT3/CDK2	5.71107223468144
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	50/2614	93/9376	1.92840865151253	MYC/LAMA2/GADD45A/CKS2/LAMB1/COL4A1/NFKBIA/PTEN/AKT1/CASP3/CDKN1B/CKS1B/PIK3CA/COL4A5/ITGAV/FHIT/CYCS/NFKB1/BCL2/COL4A4/COL4A2/CDK4/PTK2/TRAF4/LAMA1/BAX/ITGA6/COL4A3/POLK/MAX/ZBTB17/SKP2/GADD45B/PIK3R3/TRAF6/RB1/AKT3/GADD45G/CDKN2B/CASP9/TP53/CHUK/COL4A6/TRAF2/TRAF1/TRAF5/E2F3/LAMC1/BAK1/CDK2	5.5941914416079
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	62/2614	125/9376	1.7790726855394	CERS2/S1PR3/ORMDL1/SPTSSA/TNFRSF1A/PTEN/AKT1/MAPK10/GNAI3/PIK3CA/DEGS1/BDKRB2/PRKCA/GNAI1/NSMAF/SPTLC1/NFKB1/MAPK1/MAPK8/BCL2/BID/PPP2CB/PLCB3/MAP2K2/RAF1/CERS5/SGPP1/GNA12/NRAS/MAPK9/BAX/SGMS2/MAP2K1/PPP2R3A/FYN/S1PR2/CERS4/KRAS/PIK3R3/AKT3/CERS6/PPP2R5C/TP53/PLD1/PPP2R2A/TRAF2/PPP2R5A/ORMDL3/PDPK1/PPP2CA/GNA13/SPHK1/MAPK12/MAPK14/PPP2R3B/PPP2R5B/MAP3K5/SGPL1/SPTLC2/ASAH1/TNF/SMPD2	5.45179467095259
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	66/2614	137/9376	1.7279667595597	FAS/GADD45A/ACTG1/ERN1/NFKBIA/TNFRSF1A/AKT1/EIF2AK3/CASP3/MAPK10/TUBA3D/PIK3CA/CASP7/MCL1/CTSK/CAPN2/CYCS/EIF2S1/NFKB1/CASP8/HTRA2/MAPK1/MAPK8/BCL2/BID/MAP2K2/ATM/CTSC/RAF1/NRAS/MAPK9/BAX/MAP2K1/DDIT3/FADD/PMAIP1/KRAS/CASP10/GADD45B/CASP2/AIFM1/PIK3R3/AKT3/TNFRSF10B/GADD45G/PARP4/CASP9/TP53/CHUK/BBC3/TUBA1A/TRAF2/PARP2/ITPR3/TRAF1/PDPK1/LMNB2/PTPN13/PIDD1/BAK1/PARP3/MAP3K5/NGF/DFFB/TNF/LMNA	5.33654524202972
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	45/2614	83/9376	1.94467233893493	SKP1/PHC2/PHF1/USP45/UBE2D1/PCGF5/SCML1/MBD5/HDAC1/OGT/TFDP1/RNF2/AUTS2/PHC3/AEBP2/EED/PCGF2/L3MBTL3/SUZ12/FOXK2/PHC1/SCML2/MAX/CSNK2B/RYBP/FBRSL1/USP7/FBRS/PCGF1/WDR5/CBX8/ASXL3/SCMH1/PCGF3/E2F6/PCGF6/BMI1/FOXK1/UBE2D3/TEX10/MTF2/CBX7/YY2/EPOP/WDR5B	5.37456256850213
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	112/2614	268/9376	1.4989779488175	TXN/SDHD/SNCAIP/DUSP1/NDUFB5/PSMA2/HSPA5/PSMA3/NDUFB3/ERN1/PSMA5/SLC39A14/NDUFC2/EIF2AK3/CASP3/PSMD11/PSMB2/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/TUBA3D/GNAI3/ATP5F1C/SDHC/SLC39A1/NDUFA9/COX7A2L/PSMB3/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/PSMD12/NDUFB6/CAMK2D/CYCS/GNAI1/MFN1/EIF2S1/UQCRFS1/PSMB5/NDUFA8/UBE2J2/PSMC4/HTRA2/PSMC6/MAPK8/VDAC3/UQCRH/PSMC2/VDAC2/UBE2L6/NDUFS4/NDUFA7/PSMA1/PSMD6/PPIF/MCU/UBE2G1/NDUFS3/TUBB2A/PSMD9/SLC11A2/UBE2J1/ATP5MC1/XBP1/VDAC1/MAPK9/BAX/ATP5PB/DDIT3/SLC39A6/UBE2G2/UCHL1/SLC39A3/KEAP1/GNAL/ATP5PO/NDUFA10/PSMB4/NDUFB4/PSMA4/CASP9/TP53/NDUFA5/TUBA1A/CALM2/TUBB6/PSMA6/TUBB2B/ITPR3/SLC39A13/PSMB1/CYC1/KIF5A/PARK7/UBE2L3/NDUFA12/ATP5MC2/COX6C/COX8A/PSMB7/MAOB/MAP3K5/UBC/COX6A1/SLC39A8/PSMB6/COX5A/COX7B	5.15273830247867
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	105/2614	248/9376	1.51862181306612	MYC/TXN/RIPK2/ACTG1/MYL12B/NFKBIA/TNFRSF1A/DYNLT3/ARPC1A/RAB9A/AKT1/ACTR10/DYNLL1/PAK3/SKP1/CTNNB1/CASP3/ARPC3/M6PR/MAPK10/TUBA3D/PIK3CA/CXCL8/CASP7/DYNLT1/CDC42/MAP2K3/ARL8A/DCTN6/IL6/ARF1/PFN2/CYCS/DYNC2LI1/ACTR3/NFKB1/CASP8/WASF3/MYD88/MAPK1/RHOB/ACBD3/MAPK8/BCL2/ARL8B/DYNC2H1/EXOC5/MAP2K2/TLR4/MLKL/STX10/PIK3C3/ELMO2/ARF6/TUBB2A/RAF1/FBXO22/HSP90AB1/CASP1/SNX18/ARPC5L/IRAK4/EXOC2/MYL12A/MAPK9/BAX/ACTR1B/BRK1/MAP2K1/CASP4/KPNA4/FADD/RAB7A/MAP3K7/TCF7/TRAF6/NCKAP1/AKT3/TAB3/TNFRSF10B/CYTH2/WASL/CHUK/HSP90AA1/TUBA1A/TRAF2/TUBB6/TUBB2B/PLEKHM2/PFN1/RRAS/KIF5A/RALA/ACTR2/MAPK12/ARPC1B/MAPK14/MYO6/ARPC4/ACTR3C/ANXA2/BAK1/ACTR3B/SNX9/TNF	5.1462354298101
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	33/2614	56/9376	2.11367362553284	HSPA1B/SEC22B/HSPA1A/HSPA8/NFKBIA/CXCL1/CASP3/HBS1L/SAR1B/HSPD1/CXCL8/CASP7/CLK4/IL6/ARF1/CYCS/NFKB1/CASP8/MYD88/TLR4/CASP1/C3/EEF1A1/RAB1A/CASP9/CXCL2/BCL2L13/SAR1A/HSPA1L/CLK1/VCP/BNIP3/TNF	5.19690572557918
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	42/2614	78/9376	1.93137543405332	LSM6/LSM8/LSM1/EXOSC3/MPHOSPH6/C1D/HSPA9/LSM5/HSPD1/PATL1/BTG2/PFKM/BTG3/EXOSC8/EXOSC7/PNPT1/CNOT8/LSM2/PAN3/PABPC5/EXOSC1/TENT4A/DCP2/TOB1/CNOT4/DCP1A/PAN2/DCP1B/CNOT9/XRN1/CNOT2/ZCCHC7/EXOSC5/CNOT6/EXOSC9/XRN2/DDX6/TENT4B/LSM4/PABPC4L/EXOSC6/BTG1	5.13544586903348
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	113/2614	275/9376	1.47386520136329	SDHD/HSPA1B/NDUFB5/PSMA2/HSPA5/PSMA3/NDUFB3/HSPA1A/HSPA8/PSMA5/NDUFC2/EIF2AK3/CASP3/PSMD11/PSMB2/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/TUBA3D/ATP5F1C/SDHC/PIK3CA/STIP1/NDUFA9/COX7A2L/PSMB3/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/PSMD12/ATF2/NDUFB6/IL6/PRNP/CYCS/EIF2S1/UQCRFS1/PSMB5/NDUFA8/PSMC4/PPP3CC/MAPK1/PSMC6/MAPK8/VDAC3/UQCRH/PSMC2/VDAC2/CREB5/NDUFS4/NDUFA7/PSMA1/PSMD6/PPIF/PPP3R1/MCU/CAV2/NDUFS3/TUBB2A/PSMD9/ATF6B/GSK3B/ATP5MC1/PPP3CB/VDAC1/MAPK9/IL1A/BAX/PRKCD/ATP5PB/DDIT3/FYN/CSNK2A2/CACNA1C/CACNA1D/CSNK2B/PIK3R3/ATP5PO/NDUFA10/PSMB4/NDUFB4/PSMA4/CASP9/NDUFA5/TUBA1A/TUBB6/PSMA6/TUBB2B/ITPR3/CREB3L4/PSMB1/CYC1/C7/KIF5A/NDUFA12/ATP5MC2/MAPK12/COX6C/MAPK14/HSPA1L/COX8A/LAMC1/PSMB7/EGR1/NCAM2/COX6A1/PSMB6/COX5A/COX7B/TNF	4.95880983032732
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	57/2614	119/9376	1.7180662624652	VCAM1/CEBPB/FAS/MAP3K8/JUNB/SOCS3/NFKBIA/TNFRSF1A/AKT1/IL15/CSF1/CXCL1/VEGFC/ADAM17/CASP3/MAPK10/PIK3CA/CASP7/CYLD/MAP2K3/TNFAIP3/ATF2/IL6/RHBDF1/NFKB1/CASP8/MAPK1/MAPK8/CREB5/MLKL/CXCL5/ATF6B/MAPK9/MAP2K1/FADD/IRF1/JAG1/CASP10/MAP3K7/PIK3R3/PGAM5/AKT3/TAB3/LIF/CXCL2/DNM1L/CHUK/TRAF2/CREB3L4/TRAF1/TRAF5/MAPK12/MAPK14/MAP3K5/FRMD8/MMP14/TNF	4.9012145917289
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	86/2614	200/9376	1.54234123947972	FAS/ACTG1/NFKBIA/TNFRSF1A/SEC24D/ARPC1A/PAK3/CASP3/ARPC3/SEC24A/MAPK10/TUBA3D/CXCL8/CASP7/CDC42/MYO1B/IL6/CLDN20/ARF1/ABL1/ARHGEF2/CYCS/NCK1/ACTR3/NFKB1/CASP8/WASF3/MYD88/ARHGEF11/MAPK1/MAPK8/TLR4/NCK2/ARF6/TUBB2A/CASP1/GNA12/ARPC5L/IRAK4/CLDN10/MAPK9/BAX/CTTN/BRK1/CASP4/SEC24C/FYN/FADD/IL1R1/WASF1/ARHGEF1/SEC24B/MAP3K7/CLDN23/CLDN12/TRAF6/NCKAP1/TAB3/TNFRSF10B/CYTH2/RAB1A/CASP9/WASL/CHUK/TUBA1A/TRAF2/TUBB6/TUBB2B/MYO1E/ARHGEF12/TMED10/TMBIM6/ACTR2/GNA13/PTPN11/MAPK12/ARPC1B/MAPK14/WIPF3/MYO6/ARPC4/ACTR3C/BAK1/OCLN/ACTR3B/TNF	4.82016351725997
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	71/2614	158/9376	1.61180788935915	MYC/GADD45A/CHEK2/CDC26/CCND2/SKP1/WEE1/CCNH/CDKN1B/ATR/BUB3/E2F4/CDC7/PCNA/HDAC8/ABL1/CHEK1/HDAC1/TFDP1/ANAPC7/PPP2CB/ANAPC10/ATM/MAD2L1BP/CDC27/YWHAQ/CDK4/SMAD4/NDC80/GSK3B/ANAPC13/MDM2/YWHAG/TFDP2/RBL2/CDC23/ZBTB17/SKP2/CDC16/GADD45B/CDC25B/CDC14A/CUL1/ORC4/ESCO1/PRKDC/RB1/CDC6/ANAPC4/GADD45G/PPP2R5C/CDKN2B/TP53/ORC5/DBF4/ESPL1/E2F5/PPP2R5A/CDC14B/RBX1/PPP2CA/CDK7/CDKN2D/CCNB1/FBXO5/E2F3/PPP2R5B/MAD2L1/TGFB3/CDK2/MTBP	4.82198784359491
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	50/2614	101/9376	1.77566341178877	VCAM1/F3/COL3A1/COL4A1/COL1A2/AKT1/VEGFC/CASP3/PIM1/MAPK10/CDKN1B/PIK3CA/CXCL8/SERPINE1/MMP2/COL4A5/PRKCA/CDC42/IL6/NFKB1/VEGFB/MAPK1/MAPK8/BCL2/NFATC1/PLCB3/COL4A4/COL4A2/CDK4/SMAD4/STAT1/NRAS/MAPK9/IL1A/BAX/PRKCD/COL4A3/KRAS/STAT3/PIK3R3/AKT3/COL4A6/COL1A1/AGTR1/MAPK12/STAT5B/MAPK14/EGR1/TGFB3/TNF	4.87279207893188
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	70/2614	157/9376	1.59922806641358	SDHD/FAS/NDUFB5/NDUFB3/ERN1/SOCS3/TNFRSF1A/AKT1/NDUFC2/EIF2AK3/CASP3/NDUFV2/SDHB/MAPK10/NDUFA4/SDHC/PIK3CA/CXCL8/CASP7/NDUFA9/COX7A2L/NDUFB8/NDUFAB1/UQCRC2/CDC42/NDUFB6/IL6/SREBF1/CYCS/EIF2S1/UQCRFS1/NFKB1/CASP8/NDUFA8/MLX/MAPK8/UQCRH/BID/NDUFS4/NDUFA7/PRKAA1/NDUFS3/GSK3B/PRKAB2/ADIPOR1/XBP1/MAPK9/IL1A/BAX/DDIT3/PIK3R3/AKT3/NDUFA10/NDUFB4/NDUFA5/TRAF2/CYC1/IRS1/NDUFA12/MAPK12/COX6C/MAPK14/PRKAB1/COX8A/MAP3K5/COX6A1/PPARG/COX5A/COX7B/TNF	4.70761471628155
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	77/2614	180/9376	1.53437048372014	FAS/IFNGR1/SRSF9/OAS1/PILRA/SRSF1/SRSF7/TBK1/IFNGR2/SOCS3/NFKBIA/HLA-F/OAS2/TNFRSF1A/TAP1/CALR/AKT1/PPP1CB/PPP1CC/B2M/CASP3/CGAS/SRSF6/IRF7/PIK3CA/TAP2/SRSF2/PDIA3/STAT2/IL6/CYCS/EIF2S1/RHEB/RNASEL/NFKB1/CASP8/NXF1/ALYREF/MYD88/EIF2B1/BCL2/BID/STAT1/EIF2B3/IRAK4/SP100/BAX/SRSF8/FADD/EIF2B2/HLA-B/C3/EIF2B5/MAP3K7/HLA-DOB/PIK3R3/TICAM1/TRAF6/AKT3/TSC1/CASP9/TP53/CHUK/TRAF2/PILRB/EIF2AK2/TNFSF14/SRPK1/IFNAR2/SRSF5/TRAF5/PTPN11/SRSF4/ITGA5/BAK1/NECTIN2/TNF	4.50070014538175
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	73/2614	169/9376	1.5493451284164	TBK1/ERN1/PTEN/AKT1/EIF2AK3/VMP1/ATG5/TANK/ATG4C/MAPK10/SUPT20H/PIK3CA/WDR41/NRBF2/HIF1A/ATG16L1/LAMP2/CALCOCO2/EIF2S1/RHEB/WIPI1/RRAGA/MAPK1/ATG101/MAPK8/BCL2/PPP2CB/C9orf72/STK11/MAP2K2/PRKAA1/DDIT4/RRAGC/PIK3C3/MAP1LC3B/RAF1/GORASP2/NRAS/MAPK9/RAB8A/EPG5/PRKCD/GABARAPL2/MAP2K1/BIRC6/STX7/RAB7A/STX17/PIK3R4/KRAS/RRAGB/ATG2B/MAP3K7/LAMP1/WDFY3/PIK3R3/TRAF6/MTMR4/AKT3/TSC1/RAB33B/RAB1A/ATG3/BECN1/GORASP1/PDPK1/PPP2CA/RRAS/IRS1/WIPI2/DEPTOR/UBC/BNIP3	4.48054047510847
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	69/2614	158/9376	1.56640485022227	WNT2/TNFRSF1A/PTEN/AKT1/FNIP1/EIF4E/FZD2/SOS2/PIK3CA/LAMTOR3/PRKCA/SLC3A2/CAB39/ATP6V1G1/RHEB/RRAGA/MAPK1/RICTOR/MAPKAP1/STK11/MAP2K2/WDR59/PRKAA1/FZD1/SEC13/ATP6V1C1/DDIT4/RRAGC/RAF1/FZD8/GSK3B/NRAS/MAP2K1/SKP2/WNT6/KRAS/RRAGB/FLCN/TELO2/PIK3R3/DVL3/ATP6V1H/AKT3/BRAF/TSC1/SEH1L/LRP6/MIOS/CHUK/LAMTOR1/DVL2/ATP6V1E2/LPIN3/EIF4B/PDPK1/STRADB/IRS1/CASTOR2/TBC1D7/ATP6V1D/SLC38A9/STRADA/ATP6V1A/ATP6V1C2/DEPTOR/FZD10/LAMTOR5/TNF/LAMTOR2	4.46414201226768
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	26/2614	44/9376	2.11949641788969	GTF2B/GTF2H2/GTF2A2/TBPL1/CCNH/TAF12/TAF7/TAF13/TAF9/GTF2F2/GTF2H1/GTF2H3/GTF2A1/GTF2H5/TAF10/ERCC3/GTF2I/GTF2E1/TAF9B/GTF2H2C/TAF8/CDK7/TAF7L/TAF4B/TBP/TAF5	4.62767155900006
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	92/2614	227/9376	1.45369730593315	SOD2/SDHD/MGST1/NDUFB5/PRKD3/NDUFB3/CAT/NFKBIA/PTEN/AKT1/NDUFC2/MGST3/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/ATP5F1C/SDHC/NQO1/SOS2/PIK3CA/NDUFA9/COX7A2L/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/GSTO1/NDUFB6/HIF1A/ABL1/UQCRFS1/NFKB1/NDUFA8/MAPK1/MAPK8/VDAC3/UQCRH/VDAC2/CBR1/GSTM3/NDUFS4/MAP2K2/NDUFA7/PPIF/PTK2/NDUFS3/ACP1/RAF1/ATP5MC1/NRAS/VDAC1/MAPK9/PRKCD/MAP2K1/ATP5PB/KRAS/GSTA4/PRKD1/PIK3R3/KEAP1/GSTM2/AKT3/BRAF/ATP5PO/GSTT2B/ARNT/NDUFA10/NDUFB4/PLD1/CHUK/NDUFA5/EPHX2/GSTM5/EPHX1/PDPK1/CYC1/HGF/AKR1C1/NDUFA12/PTPN11/ATP5MC2/MAPK12/COX6C/MAPK14/AKR1C2/COX8A/MAP3K5/COX6A1/COX5A/COX7B	4.30222541827832
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	87/2614	214/9376	1.45820134573719	FAS/TRIM5/TBK1/GNG4/NFKBIA/HLA-F/TNFRSF1A/TAP1/CALR/AKT1/PAK3/SKP1/WEE1/B2M/CASP3/CGAS/MAPK10/AP1S1/GNAI3/AP1G1/PIK3CA/TAP2/ATR/PRKCA/MAP2K3/PDIA3/ELOC/CHEK1/CYCS/GNAI1/NFKB1/CASP8/MYD88/GNB2/PPP3CC/MAPK1/MAPK8/BCL2/BID/NFATC1/MAP2K2/CUL4B/ATM/TLR4/PPP3R1/PTK2/RNF7/RAF1/IRAK4/NRAS/PPP3CB/MAPK9/CFL2/BAX/GNG5/MAP2K1/CUL4A/APOBEC3B/FADD/HLA-B/KRAS/CUL1/MAP3K7/PIK3R3/TRAF6/GNG12/AKT3/BTRC/CASP9/APOBEC3G/CHUK/TRAF2/CALM2/ITPR3/RBX1/CRKL/TRAF5/MAPK12/MAPK14/APOBEC3F/CUL5/CCNB1/BAK1/GNG10/CFL1/TNF/LIMK2	4.21569274054673
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	27/2614	48/9376	2.01759755164499	HMGCS1/HADHB/ALDH2/HIBCH/AOX1/DLD/MCEE/HIBADH/ALDH3A2/BCAT1/HSD17B10/HADH/PCCA/ALDH9A1/ECHS1/ACADM/ACAA2/ACAD8/AACS/AUH/ACAT2/ALDH6A1/MCCC1/BCKDHB/ACAT1/OXCT1/ALDH1B1	4.39443707387051
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	100/2614	253/9376	1.41772335644795	RIPK2/UBE2N/ACTG1/TBK1/MYL12B/NFKBIA/TNFRSF1A/ARPC1A/PPID/AKT1/ATG5/SKP1/TIFA/ARPC3/CGAS/MAPK10/PIK3CA/CXCL8/CD44/BCL10/CDC42/UBE2D1/ARF1/PFN2/ARHGEF2/ATG16L1/CAPN2/CYCS/CALCOCO2/ACTR3/NFKB1/WIPI1/MYD88/RRAGA/MAPK1/MAPK8/BCL2/PLCB3/UBE2V2/ATM/TLR4/ACTN1/RRAGC/PIK3C3/PTK2/MAP1LC3B/ELMO2/ARF6/MALT1/CASP1/GSK3B/ARPC5L/MDM2/MYL12A/VDAC1/MAPK9/BAX/CTTN/PRKCD/VCL/CASP4/IL1R1/C3/PIK3R4/WASF1/RRAGB/CUL1/MAP3K7/PIK3R3/TRAF6/AKT3/TAB3/BTRC/CYTH2/BCAR1/U2AF1L4/TP53/BECN1/WASL/CHUK/TRAF2/ITPR3/GLMN/PFN1/UBE2D3/RBX1/CRKL/ACTR2/TRAF5/MAPK12/WIPI2/ARPC1B/MAPK14/ARPC4/ITGA5/ACTR3C/UBC/BNIP3/ACTR3B/TNF	4.18775271352031
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	99/2614	250/9376	1.42038867635807	HSPA1B/ARF4/PDGFRA/HSPA1A/HSPA8/HLA-F/ARPC1A/WASHC3/SNX3/SPART/PSD3/CAPZA2/ARPC3/VPS37A/ARFGAP3/STAM/VPS29/CHMP5/CDC42/VPS26A/STAM2/SNX1/DNM1/SNX2/ARF1/EPS15L1/ACTR3/PDCD6IP/ZFYVE16/RAB10/SPG21/ARFGEF1/CLTA/RUFY2/STAMBP/ARAP1/TSG101/EPS15/CAV2/VPS45/RAB4A/RAB22A/PSD/CHMP7/ARF6/SNF8/ARPC5L/WASHC5/MDM2/RAB8A/NEDD4/VTA1/SNX4/WASHC4/WASHC2A/RUFY1/MVB12A/HLA-B/CAPZA1/RAB7A/GRK4/RAB11FIP2/VPS25/CAPZB/CHMP1B/TRAF6/PIP5K1A/CHMP2B/EHD1/BIN1/CYTH2/ACAP2/PLD1/WASL/AMPH/ARFGEF2/ZFYVE9/SMURF2/ASAP3/CBLB/PARD3/SMAP1/KIF5A/ARFGAP1/ACTR2/AGAP6/ARPC1B/WIPF3/HSPA1L/RAB11FIP3/ARPC4/VPS37D/GIT2/AGAP4/ACTR3C/LDLRAP1/PARD6G/ACTR3B/SNX6	4.18872287061799
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	118/2614	308/9376	1.37417899621419	SOD2/SDHD/NDUFB5/PSMA2/PSMA3/NDUFB3/IFT57/ERN1/PSMA5/NDUFC2/ACTR10/TBPL1/POLR2B/CASP3/PSMD11/PSMB2/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/TUBA3D/ATP5F1C/SDHC/NDUFA9/COX7A2L/PSMB3/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/PSMD12/POLR2C/NRBF2/DCTN6/NDUFB6/CYCS/POLR2H/HDAC1/UQCRFS1/WIPI1/CASP8/PSMB5/NDUFA8/PSMC4/POLR2K/ATG101/PSMC6/MAPK8/GPX8/VDAC3/UQCRH/PSMC2/TFAM/VDAC2/PLCB3/CLTA/CREB5/NDUFS4/NDUFA7/PSMA1/PSMD6/GRIA4/PPIF/PIK3C3/NDUFS3/TUBB2A/PSMD9/ATP5MC1/VDAC1/MAPK9/BAX/ACTR1B/ATP5PB/PIK3R4/DNAH11/ATG2B/POLR2J/ATP5PO/NDUFA10/PSMB4/NDUFB4/PSMA4/DNAH14/CASP9/TP53/BECN1/NDUFA5/BBC3/DNAL4/TUBA1A/TRAF2/TUBB6/PSMA6/TUBB2B/CREB3L4/PSMB1/DLG4/CYC1/POLR2F/KIF5A/POLR2D/NDUFA12/ATP5MC2/COX6C/WIPI2/TAF4B/TBP/COX8A/PSMB7/MAP3K5/COX6A1/PSMB6/PPARG/COX5A/POLR2J3/DNAH7/COX7B	4.15145041176605
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	30/2614	56/9376	1.92152147775713	OSTC/MGAT2/DAD1/STT3B/DPM1/ALG5/DDOST/ALG2/ALG13/ALG14/MAN1A1/DPAGT1/MAN1C1/FUT8/ALG8/ALG1/B4GALT3/STT3A/MGAT4B/ALG6/MAN2A1/SRD5A3/RPN1/MOGS/B4GALT1/TUSC3/ALG10B/ALG10/DOLPP1/MGAT4C	4.30023674279694
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	20/2614	32/9376	2.24177505738332	TNFRSF1A/CASP3/MAPK10/CASP7/CYCS/CASP8/HTRA2/MAPK8/BCL2/BID/BOK/MAPK9/BAX/BIRC6/FADD/PMAIP1/CASP9/BECN1/BBC3/BAK1	4.37474106814321
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	38/2614	77/9376	1.7701288764793	MYC/GADD45A/NFKBIA/AKT1/CDKN1B/SOS2/PIK3CA/ABL1/HDAC1/NFKB1/MAPK1/SHC3/MAP2K2/CDK4/SMAD4/RAF1/MDM2/NRAS/BAX/MAP2K1/POLK/KRAS/GADD45B/RUNX1/PIK3R3/RB1/AKT3/BRAF/GADD45G/TP53/CHUK/CRKL/PTPN11/STAT5B/E2F3/SHC2/BAK1/TGFB3	4.21882482794893
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	62/2614	144/9376	1.54433392841962	PSMA2/PSMA3/GTF2B/ERN1/PSMA5/AKT1/TBPL1/PSMD11/PSMB2/MAPK10/SLC25A5/OPA1/PIK3CA/PSMB3/PRKCA/OMA1/ATXN2L/ATP2A2/PSMD12/NRBF2/CYCS/WIPI1/PSMB5/PSMC4/ATG101/PSMC6/MAPK8/VDAC3/PSMC2/ATXN10/VDAC2/PLCB3/PSMA1/PSMD6/PPIF/MCU/PIK3C3/PSMD9/XBP1/VDAC1/PUM2/MAPK9/PIK3R4/ATG2B/PIK3R3/AKT3/PSMB4/PSMA4/BECN1/ATXN1/TRAF2/NFYA/PSMA6/ITPR3/PSMB1/ATXN1L/WIPI2/TBP/PUM1/PSMB7/MAP3K5/PSMB6	4.09260282366294
Human Diseases	Infectious disease: viral	hsa05162	Measles	59/2614	136/9376	1.55605562806607	FAS/HSPA1B/OAS1/HSPA1A/HSPA8/TBK1/NFKBIA/OAS2/RAB9A/AKT1/CCND2/CASP3/MAPK10/IRF7/CDKN1B/PIK3CA/CD46/TNFAIP3/STAT2/IL6/RCHY1/CYCS/EIF3H/EIF2S1/NFKB1/CASP8/MYD88/MAPK8/BCL2/BID/TLR4/MX1/CDK4/STAT1/GSK3B/IRAK4/MAPK9/IL1A/BAX/CSNK2A2/FADD/CSNK2B/STAT3/MAP3K7/PIK3R3/TRAF6/AKT3/CASP9/TP53/CHUK/MX2/BBC3/EIF2AK2/IFNAR2/CBLB/STAT5B/HSPA1L/BAK1/CDK2	4.061182966246
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	47/2614	103/9376	1.63671343995365	DDX39B/EIF4A3/NXT1/CPSF6/PPP1CB/PABPN1/PPP1CC/HBS1L/PELO/ETF1/RNGTT/MAGOHB/MAGOH/WDR33/NXF1/ALYREF/PABPC5/CPSF7/PPP2CB/DAZAP1/RNPS1/NCBP1/PAPOLA/PYM1/CSTF3/GSPT1/PPP2R3A/NXT2/CSTF2/FIP1L1/CSTF1/CPSF4/NUDT21/PPP2R5C/SMG1/PPP2R2A/MSI2/PPP2R5A/PPP2CA/RNMT/CPSF3/PABPC4L/NCBP2/PPP2R3B/PAPOLG/PPP2R5B/SAP18	4.03973936460329
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	88/2614	224/9376	1.40911575035523	MYC/ZFP36/IL15RA/NRP1/NFYB/FOSL1/NFKBIA/HLA-F/TNFRSF1A/CHEK2/RAN/CALR/PTEN/AKT1/IL15/CDC26/CCND2/TBPL1/B2M/RANBP1/MAPK10/SLC25A5/PIK3CA/ADCY3/ATR/BUB3/ATF2/KAT2A/IL6/CHEK1/NFKB1/PPP3CC/MAPK1/MAPK8/VDAC3/ANAPC7/VDAC2/NFATC1/CREB5/ANAPC10/MAP2K2/ATM/PPP3R1/CDC27/CDK4/ELK4/SMAD4/CANX/ATF6B/ANAPC13/NRAS/XPO1/PPP3CB/VDAC1/MAPK9/BAX/CRTC2/MAP2K1/IL1R1/HLA-B/CDC23/KRAS/CDC16/ELK1/HLA-DOB/PIK3R3/RB1/AKT3/ANAPC4/CRTC3/KAT2B/CDKN2B/TP53/CHUK/RELB/ESPL1/CREB3L4/TCF3/STAT5B/TBP/E2F3/EGR1/ADCY6/MAD2L1/TGFB3/ETS2/CDK2/TNF	3.85312456787023
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	57/2614	133/9376	1.53721718220571	SOD2/GADD45A/CAT/PTEN/AKT1/CCND2/MAPK10/CDKN1B/SOS2/PIK3CA/IL6/SIRT1/MAPK1/MAPK8/PRMT1/STK11/MAP2K2/HOMER3/PRKAA1/ATM/SMAD4/RAF1/PRKAB2/MDM2/NRAS/MAPK9/GABARAPL2/MAP2K1/RBL2/BCL6/SETD7/SKP2/KRAS/GADD45B/STAT3/CCNG2/PLK3/USP7/PIK3R3/AKT3/BRAF/GADD45G/CDKN2B/CHUK/HOMER1/FBXO32/PDPK1/IRS1/MAPK12/MAPK14/CDKN2D/PRKAB1/CCNB1/BNIP3/TGFB3/CDK2/KLF2	3.87944934145441
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	25/2614	46/9376	1.94936961511593	PSMA2/PSMA3/PSMA5/PSMB9/PSMD11/PSMB2/PSMB3/PSMD12/PSMB8/PSMB5/PSMC4/PSMC6/PSMC2/PSMA1/PSMD6/PSME4/PSMD9/PSME2/PSMB4/PSMA4/PSMA6/PSMB1/PSMB10/PSMB7/PSMB6	4.01304720615071
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	25/2614	47/9376	1.90789366585815	FH/MDH1/ADH5/LDHB/ALDH2/ACYP1/DLD/ADH1B/ALDH3A2/GLO1/PDHB/DLAT/ALDH9A1/MDH2/ACAT2/ACYP2/PDHA1/ACACB/ME3/LDHA/ACACA/ADH1C/ME2/ACAT1/ALDH1B1	3.87942370485786
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	64/2614	156/9376	1.4715241402311	MYC/IFIT1/FAS/OAS1/TBK1/SOCS3/NFKBIA/OAS2/TNFRSF1A/AKT1/CTNNB1/CASP3/IRF7/SOS2/PIK3CA/STAT2/CLDN20/CYCS/EIF2S1/RNASEL/NFKB1/CASP8/MAPK1/BID/PPP2CB/RSAD2/MAP2K2/YWHAQ/MX1/CDK4/RAF1/STAT1/GSK3B/CLDN10/NRAS/YWHAG/BAX/EIF3E/MAP2K1/FADD/KRAS/STAT3/CLDN23/PIK3R3/CLDN12/TICAM1/TRAF6/RB1/AKT3/BRAF/CASP9/TP53/CHUK/MX2/PPP2R2A/TRAF2/EIF2AK2/IFNAR2/PPP2CA/E2F3/BAK1/OCLN/CDK2/TNF	3.69233942175391
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	122/2614	333/9376	1.31409757117485	LAMA2/FAS/LAMB1/WNT2/COL4A1/TBK1/COL1A2/HLA-F/TNFRSF1A/PTEN/AKT1/CCND2/TBPL1/CTNNB1/CASP3/MAML2/FZD2/CDKN1B/SOS2/PIK3CA/COL4A5/ITGAV/ATR/THBS2/COL6A1/HES4/CDC42/COL6A2/ATP6V1G1/ITGB5/STAT2/HDAC1/RHEB/NFKB1/CASP8/MAPK1/PPP2CB/COL4A4/CREB5/ATP6V0E1/MAP2K2/ATM/COL4A2/PDGFRB/FZD1/MX1/ATP6V1C1/CDK4/TADA3/PTK2/RAF1/LAMA1/FZD8/STAT1/GSK3B/MDM2/NRAS/BAX/ITGA6/MAP2K1/COL4A3/PPP2R3A/RBL2/FADD/IRF1/HLA-B/JAG1/WNT6/KRAS/UBE3A/TCF7/PIK3R3/OASL/TICAM1/DVL3/ATP6V1H/RB1/AKT3/TUBG1/TSC1/PPP2R5C/TP53/MAML1/CHUK/MX2/DVL2/PPP2R2A/COL4A6/PSEN1/EIF2AK2/ATP6V1E2/CREB3L4/COL1A1/THBS3/PPP2R5A/IFNAR2/PPP2CA/PARD3/CSNK1A1/LLGL1/ATP6V1D/TNC/ATP6V1A/ATP6V1C2/THBS1/DLG2/TBP/PPP2R3B/ATP6V0A2/LAMC1/ITGA5/FZD10/PPP2R5B/ISG15/BAK1/ATP6V0E2/COMP/PARD6G/CDK2/HES6/THBS4/TNF	3.62853466193665
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	31/2614	63/9376	1.764953061051	GTF2H2/POLR2B/CCNH/POLR2C/PCNA/POLR2H/ERCC4/POLR2M/GTF2H1/POLR2K/GTF2H3/CUL4B/RAD23B/GTF2H5/RPA3/CUL4A/ERCC3/POLR2J/RAD23A/GTF2H2C/RBX1/ERCC8/POLR2F/RFC4/CDK7/UVSSA/POLR2D/ERCC5/POLE2/POLR2J3/RFC5	3.78757382604669
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	84/2614	216/9376	1.3948822579274	VCAM1/SOD2/FAS/HSPA1B/HSPA5/HSPA1A/HSPA8/TBK1/ERN1/NFKBIA/TNFRSF1A/AKT1/EIF2AK3/TANK/CXCL1/CASP3/HSPA4/MAPK10/IRF7/HSPD1/PIK3CA/CXCL8/CASP7/PRKCA/CDC42/MAP2K3/CAMK2D/IL6/CYCS/EIF2S1/NFKB1/CASP8/MYD88/RAP1B/PPP3CC/CYP2A7/MAPK1/MAPK8/BCL2/BID/NFATC1/PLCB3/TLR4/PPP3R1/ABCA1/PTK2/HSP90AB1/CASP1/GSK3B/IRAK4/XBP1/NRAS/PPP3CB/MAPK9/BAX/DDIT3/KRAS/ARHGEF1/STAT3/MAP3K7/ERO1A/PIK3R3/TICAM1/TRAF6/AKT3/TNFRSF10B/CYP2B6/CASP9/TP53/MIB1/CXCL2/RAP1A/CHUK/HSP90AA1/TRAF2/CALM2/PDPK1/CYP2J2/MAPK12/MAPK14/HSPA1L/MAP3K5/PPARG/TNF	3.65046010630903
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	80/2614	205/9376	1.39974247485398	MYC/FAS/GADD45A/VIM/OAS1/SAP30/TBK1/NFKBIA/HLA-F/OAS2/TAP1/CALR/AKT1/CCND2/NFKBIE/B2M/CASP3/PSMD11/MAPK10/IRF7/CDKN1B/PIK3CA/TAP2/CD44/PSMD12/MAP2K3/PDIA3/TNFAIP3/STAT2/IL6/CYCS/HDAC1/NFKB1/CASP8/MYD88/PSMC4/PSMC6/MAPK8/BCL2/BID/PSMC2/SAP30L/PSMD6/CDK4/STAT1/IRAK4/MDM2/MAPK9/BAX/NEDD4/FADD/HLA-B/POLK/SKP2/GADD45B/STAT3/USP7/MAP3K7/HLA-DOB/PIK3R3/TRAF6/RB1/AKT3/GADD45G/CASP9/TP53/CHUK/RELB/TRAF2/EIF2AK2/ENTPD3/IFNAR2/TRAF5/MAPK12/MAPK14/E2F3/ISG15/BAK1/CDK2/TNF	3.59790529311868
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	23/2614	43/9376	1.91854237469084	ADH5/HADHB/ALDH2/ACADVL/ADH1B/ALDH3A2/ACSL1/ECI2/HADH/ALDH9A1/ECHS1/ACADM/ECI1/ACAA2/ACOX1/ACAT2/ADH1C/ACSL4/GCDH/ACSL5/CYP2U1/ACAT1/ALDH1B1	3.75338952555644
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	35/2614	75/9376	1.67385870951288	FAS/MGST1/AKT1/MGST3/CASP3/PIK3CA/TOP2B/GSTO1/CYCS/CASP8/MAPK1/MLH1/BCL2/BID/GSTM3/ATM/MDM2/MSH6/BAX/FADD/PMAIP1/GSTA4/PIK3R3/GSTM2/AKT3/ERBB2/GSTT2B/CASP9/TP53/BBC3/GSTM5/PDPK1/REV3L/BAK1/MAP3K5	3.64280146063483
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	29/2614	59/9376	1.76302309597604	MYC/GADD45A/PTEN/AKT1/CTNNB1/SOS2/PIK3CA/MAPK1/MLH1/MAP2K2/RAF1/GSK3B/NRAS/BAX/MAP2K1/POLK/KRAS/GADD45B/ELK1/TCF7/PIK3R3/AKT3/ERBB2/BRAF/GADD45G/CASP9/TP53/PDPK1/BAK1	3.65532913917357
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	76/2614	196/9376	1.39081554580516	MYC/ZFP36/FAS/IFNGR1/FGF2/TBK1/GNG4/NFKBIA/HLA-F/TNFRSF1A/AKT1/CXCL1/CTNNB1/CASP3/MAPK10/CLEC2B/IRF7/PIK3CA/CXCL8/STAT2/IL6/HIF1A/MAPKAPK2/CYCS/NFKB1/CASP8/GNB2/PPP3CC/MAPK1/MAPK8/BID/NFATC1/MAP2K2/PPP3R1/CDK4/PIK3C3/MAP1LC3B/RAF1/STAT1/GSK3B/NRAS/PPP3CB/MAPK9/BAX/GNG5/MAP2K1/FADD/HLA-B/C3/KRAS/STAT3/TCF7/PIK3R3/TICAM1/GNG12/RB1/AKT3/CASP9/ATG3/TP53/BECN1/CXCL2/CHUK/TRAF2/CALM2/EIF2AK2/MICA/ITPR3/IFNAR2/MAPK12/MAPK14/IL6ST/E2F3/BAK1/GNG10/UBC	3.43779022500391
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	73/2614	187/9376	1.40021030322124	TXN/GBP1/RIPK2/GBP3/OAS1/ANTXR1/TBK1/NFKBIA/OAS2/ATG5/TANK/CXCL1/TXNIP/MAPK10/IRF7/CXCL8/NAMPT/TNFAIP3/STAT2/IL6/ATG16L1/IFI16/TP53BP1/MFN1/RNASEL/NFKB1/CASP8/MYD88/PKN2/MAPK1/MAPK8/VDAC3/BCL2/VDAC2/PANX1/PLCB3/TLR4/TRIP6/NEK7/MCU/GBP2/MAP1LC3B/HSP90AB1/STAT1/CASP1/TRPM7/IRAK4/VDAC1/MAPK9/NLRP1/PRKCD/GABARAPL2/CASP4/FADD/MAP3K7/TICAM1/TRAF6/SUGT1/TAB3/CXCL2/DNM1L/CHUK/HSP90AA1/CARD6/ANTXR2/TRAF2/ITPR3/IFNAR2/ERBIN/TRAF5/MAPK12/MAPK14/TNF	3.43697037904165
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	65/2614	163/9376	1.43033500593782	MYC/FAS/TBK1/NFKBIA/AKT1/CASP3/MAPK10/IRF7/SOS2/PIK3CA/CXCL8/PRKCA/MAP2K3/ATF2/PCNA/STAT2/IL6/CYCS/NFKB1/CASP8/MYD88/MAPK1/MAPK8/VDAC3/BCL2/BID/NFATC1/CREB5/MAP2K2/TLR4/YWHAQ/SMAD4/RAF1/STAT1/ATF6B/IRAK4/NRAS/MAPK9/BAX/MAP2K1/FADD/KRAS/CASP10/EGR3/STAT3/ELK1/MAP3K7/PIK3R3/TICAM1/TRAF6/RB1/AKT3/BRAF/CASP9/TP53/CHUK/DDX3X/CREB3L4/MAPK12/STAT5B/MAPK14/E2F3/TGFB3/CDK2/TNF	3.44588507290383
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	86/2614	227/9376	1.35889095989403	MYC/FAS/PDGFRA/TBK1/GNG4/NFKBIA/HLA-F/TNFRSF1A/TAP1/CALR/AKT1/B2M/CTNNB1/CASP3/CGAS/GNAI3/SOS2/PIK3CA/CXCL8/TAP2/ADCY3/ITGAV/CXCL12/PRKCA/PDIA3/ATF2/IL6/CYCS/GNAI1/RHEB/NFKB1/CASP8/GNB2/PPP3CC/ARHGEF11/MAPK1/BID/NFATC1/PLCB3/CREB5/MAP2K2/PPP3R1/CDK4/PTK2/RAF1/ATF6B/GSK3B/GNA12/MDM2/NRAS/PPP3CB/BAX/GNG5/MAP2K1/FADD/IL1R1/HLA-B/KRAS/ARHGEF1/STAT3/ELK1/PIK3R3/GNG12/RB1/AKT3/TSC1/BCAR1/CASP9/TP53/CHUK/TRAF2/CALM2/ITPR3/CREB3L4/ARHGEF12/CRKL/GNA13/TRAF5/MAPK12/MAPK14/E2F3/IL10RB/BAK1/ADCY6/GNG10/TNF	3.40321573404695
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	53/2614	128/9376	1.48517597551645	NT5E/NTPCR/AK6/NME7/PPAT/ADCY3/DGUOK/PAICS/FHIT/PAPSS1/GMPS/HPRT1/PGM2/ITPA/ATIC/PRPS2/ENPP1/NPR1/PDE1A/PDE4B/GART/GMPR2/NUDT9/NME3/NUDT5/PDE6D/NME1/RRM2B/NUDT2/HDDC2/ADA/AMPD2/PGM1/PDE8B/PDE8A/ENTPD4/IMPDH2/PRPS1/DCK/ENTPD3/PDE5A/AK3/LACC1/NT5C2/ADSL/GUCY1B1/GUCY1A2/PNP/ENPP4/ADK/AMPD3/ADCY6/PDE3A	3.43622195738164
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	109/2614	300/9376	1.30321856669217	MYC/FAS/HSPA1B/GADD45A/DUSP1/MAP3K8/PDGFRA/FGF2/CACNA2D1/HSPA1A/HSPA8/DUSP5/TNFRSF1A/AKT1/CSF1/VEGFC/CASP3/JUND/MAPK10/SOS2/LAMTOR3/MAP4K3/PRKCA/CDC42/MAP2K3/CACNB2/KITLG/ATF2/STK3/MAPKAPK2/FGF7/NFKB1/MYD88/VEGFB/RAP1B/PPP3CC/MAPK1/MAPK8/NFATC1/MAP2K2/PDGFRB/PPP3R1/EFNA4/FGFR1/ELK4/PPM1B/MAPKAPK5/ECSIT/RAF1/MAP3K12/DUSP7/GNA12/IRAK4/MKNK2/NRAS/PPP3CB/CACNA2D3/MAPK9/IL1A/NR4A1/CACNA1H/MAP2K1/DDIT3/CACNA1C/IL1R1/DUSP8/CACNA1G/MAX/KRAS/CACNA1D/GADD45B/CDC25B/PPM1A/ELK1/RASA2/MAP3K7/EFNA5/TRAF6/GNG12/AKT3/ERBB2/BRAF/EPHA2/GADD45G/MAPK7/TP53/MAP3K4/MAP3K13/RAP1A/CHUK/RELB/TRAF2/NF1/ANGPT1/CACNB4/RRAS/CRKL/HGF/PLA2G4A/PLA2G4C/MAPK12/MAPK14/HSPA1L/MAP3K5/PDGFC/NGF/TGFB3/PSPN/TNF	3.3187154783793
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	37/2614	83/9376	1.59895281201316	SOD2/SCP2/CAT/PEX13/FAR1/NUDT12/HSD17B4/PEX7/ACSL1/GSTK1/PRDX1/PEX3/ABCD4/ECI2/CROT/ABCD3/AGPS/PEX5/PHYH/MPV17L2/ECH1/ACOX1/PEX1/MPV17/PEX2/NUDT7/ACSL4/GNPAT/ACSL5/EPHX2/PXMP4/FAR2/HACL1/NUDT13/NUDT19/PXMP2/PAOX	3.40764647282298
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	14/2614	23/9376	2.18329396892984	HMGCS1/NUS1/IDI1/ZMPSTE24/HMGCR/GGPS1/FNTA/ICMT/ACAT2/RCE1/ACAT1/PDSS2/PDSS1/FNTB	3.53249819355427
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	38/2614	87/9376	1.5666657872288	MYC/GADD45A/AKT1/CTNNB1/CASP3/MAPK10/SOS2/PIK3CA/CYCS/MAPK1/MAPK8/MLH1/BCL2/MAP2K2/RALB/SMAD4/RAF1/GSK3B/MSH6/NRAS/MAPK9/BAX/MAP2K1/PMAIP1/POLK/KRAS/GADD45B/TCF7/PIK3R3/AKT3/BRAF/GADD45G/CASP9/TP53/BBC3/RALA/BAK1/TGFB3	3.30143677127519
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	48/2614	116/9376	1.48420969316413	SDHD/FH/MDH1/ADH5/CAT/HIBCH/GCSH/IDH3A/SDHB/GLUD1/RPE/SDHC/SUCLA2/DLD/RPIA/PGP/MCEE/PFKM/ADPGK/ESD/SUCLG2/ACO1/TKT/PRPS2/DLST/PDHB/DLAT/SHMT2/GOT1/PCCA/ECHS1/MDH2/PGAM1/SUCLG1/ACOX1/ACAT2/PDHA1/ME3/ALDH6A1/TALDO1/PRPS1/PSPH/ME2/ACAT1/RGN/PGLS/GLUD2/CPS1	3.26255488944525
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	66/2614	170/9376	1.39253791799811	MYC/GADD45A/MGST1/WNT2/ACTG1/PTEN/AKT1/CTNNB1/MGST3/ACTL6A/SMARCE1/FZD2/NQO1/SOS2/PIK3CA/PRKCA/GSTO1/MAPK1/SHC3/GSTM3/MAP2K2/TXNRD1/FZD1/CDK4/SMAD4/ARID2/RAF1/FZD8/PBRM1/GSK3B/ARID1B/PHF10/NRAS/BAX/MAP2K1/SMARCD3/SMARCB1/POLK/WNT6/KRAS/GADD45B/ELK1/GSTA4/TCF7/PIK3R3/DVL3/KEAP1/RB1/GSTM2/AKT3/BRAF/GSTT2B/GADD45G/TP53/LRP6/DVL2/GSTM5/CSNK1A1/HGF/FRAT2/E2F3/SHC2/GAB1/FZD10/BAK1/TGFB3	3.21123017929779
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	77/2614	204/9376	1.35385630916483	MYC/TWIST1/PLAU/FAS/FGF2/WNT2/ACTG1/SDC4/COL1A2/AKT1/DDX5/PPP1CB/PPP1CC/DCN/CTNNB1/CASP3/FZD2/SOS2/PIK3CA/MMP2/ITGAV/CD44/SDC2/PRKCA/CDC42/CAMK2D/ITGB5/HIF1A/PPP1R12B/MAPK1/MAP2K2/TLR4/PLAUR/FZD1/HOXD10/CAV2/FGFR1/PTK2/RAF1/FZD8/MDM2/NRAS/CTTN/MAP2K1/HSPB2/TFAP4/ESR1/WNT6/KRAS/ARHGEF1/STAT3/ELK1/PIK3R3/AKT3/ERBB2/BRAF/TP53/TWIST2/ITPR3/COL1A1/ARHGEF12/EIF4B/PDPK1/SMO/RRAS/HPSE/LUM/HGF/PTPN11/ANK2/MAPK12/MAPK14/THBS1/GAB1/ITGA5/FZD10/TNF	3.17695344445169
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	87/2614	235/9376	1.32789399143727	SDHD/NDUFB5/NDUFB3/ACTG1/COA6/NDUFC2/COX11/NDUFV2/NDUFAF1/SDHB/ACTL6A/SMARCE1/NDUFA4/ATP5F1C/SDHC/SOS2/ADCY3/NDUFA9/COX7A2L/COA4/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/NDUFAF4/KDM1A/MAP2K3/ATF2/NDUFB6/COA1/RHEB/UQCRFS1/NDUFA8/NDUFAF7/PRKG1/UQCRH/ACSL1/CREB5/NDUFS4/NPR1/NDUFA7/PRKAA1/ZNF516/FGFR1/NDUFS3/ATP5MC1/ARID1B/PRKAB2/NRAS/SMARCD3/ATP5PB/SMARCB1/KRAS/COA5/SLC25A20/COX10/ATP5PO/TSC1/ACSL4/NDUFA10/NDUFB4/ACSL5/COA3/NDUFA5/COX15/CREB3L4/COX18/COX14/CYC1/SIRT6/NDUFA12/NDUFAF5/ATP5MC2/MAPK12/NDUFAF6/COX6C/MAPK14/PRKAB1/COX8A/SLC25A29/MAP3K5/ADCY6/COX6A1/PPARG/COX5A/COX7B/ATP5MGL	3.16498300036085
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	44/2614	105/9376	1.50305680037891	NFKBIA/AKT1/MAPK10/PIK3CA/BCL10/CYLD/STAT2/IL6/MAPKAPK2/NFKB1/CASP8/PPP3CC/MAPK1/MAPK8/NFATC1/PPP3R1/RAF1/MALT1/STAT1/CASP1/MDM2/NRAS/PPP3CB/MAPK9/PRKCD/IRF1/KRAS/EGR3/PLK3/PIK3R3/AKT3/CHUK/RELB/CALM2/ITPR3/ARHGEF12/CBLB/RRAS/PTPN11/MAPK12/MAPK14/IL23A/IL17D/TNF	3.22291780578222
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	37/2614	85/9376	1.56133039290697	NT5E/NTPCR/AK6/NME7/DGUOK/CMPK1/DUT/GMPS/HPRT1/DCTD/ITPA/CMPK2/ENPP1/GMPR2/NME3/DTYMK/CTPS1/UCKL1/NME1/RRM2B/HDDC2/ADA/DCTPP1/AMPD2/ENTPD4/IMPDH2/DCK/UCK2/ENTPD3/UCK1/AK3/LACC1/NT5C2/ADSL/PNP/ADK/AMPD3	3.23219561623034
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	49/2614	120/9376	1.46462637082377	RIPK2/NFKBIA/AKT1/NFKBIE/MAPK10/SOS2/PIK3CA/CDC42/CAMK2D/MAPKAPK2/ABL1/NFKB1/RAP1B/MAPK1/SHC3/MAPK8/BCL2/MAP2K2/RAF1/GSK3B/IRAK4/NRAS/MAPK9/BAX/PRKCD/MAP2K1/KRAS/PIK3R3/IRAK2/TRAF6/AKT3/BRAF/MAPK7/TP53/RAP1A/ZNF274/PSEN1/CALM2/IRAK3/PDPK1/IRS1/CRKL/PTPN11/MAPK12/MAPK14/SHC2/GAB1/MAP3K5/NGF	3.18481090842413
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	55/2614	138/9376	1.42953771775168	ACTG1/TBK1/NFKBIA/ARPC1A/AKT1/ARPC3/MAPK10/PIK3CA/CXCL8/CDC42/MAP2K3/IL6/ACTR3/NFKB1/MYD88/PKN2/MAPK1/MAPK8/NFATC1/MAP2K2/TLR4/PTK2/ELMO2/ARF6/CASP1/GSK3B/ARPC5L/IRAK4/MAPK9/MAP2K1/ARHGEF1/MAP3K7/PIK3R3/TICAM1/TRAF6/AKT3/PIP5K1A/BCAR1/WASL/CHUK/TRAF2/ARHGEF12/CRKL/ACTR2/ARHGEF28/MAPK12/ARPC1B/MAPK14/WIPF3/ARPC4/ITGA5/GIT2/ACTR3C/ACTR3B/TNF	3.16047759666127
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	29/2614	63/9376	1.65108512162835	SETDB2/ALDH2/KMT5A/DLD/ALDH3A2/AADAT/PLOD2/EHMT1/DLST/NSD1/HADH/PRDM6/SMYD3/ALDH9A1/ECHS1/SUV39H2/PHYKPL/SETD7/DOT1L/SETD2/ACAT2/SMYD2/TMLHE/GCDH/CAMKMT/ACAT1/KMT5B/SETMAR/ALDH1B1	3.22377030797132
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	34/2614	77/9376	1.58379952106042	GADD45A/AKT1/MAPK10/PIK3CA/CDC42/NFKB1/MAPK1/MAPK8/RALB/CDK4/SMAD4/RAF1/STAT1/MAPK9/BAX/MAP2K1/POLK/KRAS/GADD45B/STAT3/PIK3R3/RB1/AKT3/ERBB2/BRAF/GADD45G/CASP9/TP53/PLD1/CHUK/RALA/E2F3/BAK1/TGFB3	3.19809838225254
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	66/2614	173/9376	1.36838986161664	FAS/IFNGR1/OAS1/ACTG1/NXT1/TBK1/IFNGR2/SOCS3/NFKBIA/OAS2/TNFRSF1A/AKT1/KPNA2/PABPN1/CASP3/SLC25A5/IRF7/PIK3CA/CXCL8/NUP98/PRKCA/STAT2/IL6/CYCS/CALCOCO2/EIF2S1/RNASEL/NFKB1/CASP8/NXF1/MYD88/MAPK1/BID/RSAD2/MAP2K2/TLR4/MX1/CDK4/DNAJC3/RAF1/STAT1/CASP1/IRAK4/XPO1/VDAC1/IL1A/BAX/MAP2K1/NXT2/TRIM25/RAE1/FADD/HLA-DOB/PIK3R3/TICAM1/AKT3/CPSF4/TNFRSF10B/CASP9/CHUK/MX2/EIF2AK2/IFNAR2/KPNA5/BAK1/TNF	3.04065296868931
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	45/2614	110/9376	1.46734367392363	MYC/BAMBI/ID3/BMP2/FST/ID2/SKP1/TGIF1/ID4/SMAD7/DCN/FMOD/ID1/E2F4/HDAC1/TFDP1/ZFYVE16/MAPK1/PPP2CB/RGMA/LEMD3/SMAD4/LEFTY2/ACVR1B/SKIL/CHRD/NEO1/CUL1/GDF7/BMPR1A/CDKN2B/NBL1/ACVR1/ZFYVE9/SMURF2/E2F5/RGMB/RBX1/PPP2CA/SMAD6/THBS1/SMAD9/TGFB3/LRRC32/TNF	3.06540181073315
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	19/2614	37/9376	1.84189085795819	MYC/GADD45A/CTNNB1/TFG/MAPK1/MAP2K2/NRAS/BAX/MAP2K1/POLK/KRAS/GADD45B/TCF7/BRAF/GADD45G/TP53/BAK1/PAX8/PPARG	3.19012216443868
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	17/2614	32/9376	1.90550879877582	LDHB/HIBCH/ACSS3/SUCLA2/DLD/MCEE/ECHDC1/SUCLG2/PCCA/ECHS1/SUCLG1/ACOX1/ACACB/ALDH6A1/LDHA/ACACA/BCKDHB	3.19008382880314
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	31/2614	70/9376	1.5884577549459	FH/AKT1/PAK3/CUL2/SOS2/PIK3CA/PRCC/CDC42/ELOC/HIF1A/RAP1B/MAPK1/MAP2K2/RAF1/NRAS/MAP2K1/KRAS/FLCN/EGLN1/PIK3R3/AKT3/BRAF/ARNT/RAP1A/VHL/RBX1/CRKL/HGF/PTPN11/GAB1/TGFB3	3.07244157418536
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	32/2614	73/9376	1.57231346490447	GADD45A/AKT1/SOS2/PIK3CA/FHIT/PRKCA/MAPK1/MAP2K2/CDK4/RAF1/NRAS/BAX/MAP2K1/POLK/KRAS/GADD45B/STAT3/PIK3R3/RB1/AKT3/ERBB2/BRAF/GADD45G/CASP9/TP53/RASSF1/PDPK1/KIF5A/HGF/STAT5B/E2F3/BAK1	3.05200141003774
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	16/2614	30/9376	1.91298138230043	SDHD/FH/MDH1/IDH3A/SDHB/SDHC/SUCLA2/DLD/SUCLG2/ACO1/DLST/PDHB/DLAT/MDH2/SUCLG1/PDHA1	3.11394191287833
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	75/2614	203/9376	1.3251872260394	LAMA2/LAMB1/PDGFRA/ACTG1/COL4A1/MYL12B/COL1A2/PTEN/AKT1/CCND2/PPP1CB/PAK3/PPP1CC/VEGFC/CTNNB1/MAPK10/SOS2/PIK3CA/COL4A5/ITGAV/THBS2/COL6A1/PRKCA/CDC42/COL6A2/ITGB5/CAPN2/VEGFB/PPP1R12B/RAP1B/MAPK1/SHC3/MAPK8/BCL2/COL4A4/COL4A2/PDGFRB/ACTN1/CAV2/PTK2/RAF1/LAMA1/GSK3B/MYL12A/MAPK9/ITGA6/VCL/MAP2K1/COL4A3/FYN/ELK1/PIK3R3/AKT3/ERBB2/BRAF/PIP5K1A/BCAR1/RAP1A/COL4A6/ARHGAP5/COL1A1/THBS3/PARVA/PDPK1/CRKL/HGF/TNC/THBS1/SHC2/LAMC1/ITGA5/EMP1/PDGFC/COMP/THBS4	2.91223653653679
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	25/2614	54/9376	1.66057411658024	FANCL/ATR/WDR48/FANCF/PMS2/ERCC4/MLH1/UBE2T/REV1/RPA3/POLI/POLK/FANCM/TELO2/FAN1/RAD51C/PALB2/TOP3A/RMI1/REV3L/FANCB/FANCG/FANCA/CENPS/FAAP100	3.02666761483718
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	31/2614	71/9376	1.56608511051004	SOCS2/SOCS3/AKT1/CCND2/SOCS1/MAPK10/SOS2/PIK3CA/NFKB1/MAPK1/SHC3/MAPK8/MAP2K2/RAF1/STAT1/GSK3B/NRAS/MAPK9/MAP2K1/ESR1/IRF1/KRAS/STAT3/PIK3R3/AKT3/SOCS6/SOCS4/MAPK12/STAT5B/MAPK14/SHC2	2.97682678135374
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	19/2614	38/9376	1.79342004590666	NNMT/NT5E/AOX1/NAMPT/NUDT12/NADK2/BST1/SIRT1/ENPP1/NNT/NADK/NMNAT1/SIRT4/NUDT13/SIRT6/NT5C2/NMNAT3/PNP/CD38	3.04697491591025
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	45/2614	112/9376	1.44114110831785	LAMA2/HSPA1B/LAMB1/IFNGR1/HSPA1A/HSPA8/IFNGR2/NFKBIA/TNFRSF1A/AKT1/SOCS1/CASP3/MAPK10/GNAI3/MAP2K3/CYCS/GNAI1/NFKB1/CASP8/MYD88/MAPK1/MAPK8/BCL2/TLR4/PPIF/LAMA1/STAT1/IRAK4/MAPK9/ITGA6/STAT3/MAP3K7/HLA-DOB/TRAF6/AKT3/CASP9/CHUK/PDPK1/MAPK12/MAPK14/HSPA1L/LAMC1/IL10RB/TGFB3/TNF	2.92003538808106
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	75/2614	205/9376	1.3122585701756	SDHD/COL3A1/NDUFB5/NDUFB3/COL1A2/PTEN/AKT1/NDUFC2/PPP1CB/PPP1CC/NDUFV2/SDHB/MAPK10/SLC25A5/NDUFA4/ATP5F1C/SDHC/PIK3CA/MMP2/NDUFA9/COX7A2L/ATP5MC3/NDUFB8/PRKCA/NDUFAB1/UQCRC2/ATP2A2/NDUFB6/CAMK2D/GFPT2/MPC2/UQCRFS1/NFKB1/NDUFA8/MAPK8/VDAC3/UQCRH/VDAC2/PLCB3/NDUFS4/NDUFA7/MPC1/PDHB/PPIF/GSR/NDUFS3/GSK3B/ATP5MC1/VDAC1/MAPK9/PRKCD/ATP5PB/GFPT1/PIK3R3/PDHA1/AKT3/ATP5PO/NDUFA10/NDUFB4/NDUFA5/COL1A1/CYC1/AGTR1/IRS1/NDUFA12/ATP5MC2/MAPK12/COX6C/MAPK14/COX8A/TGFB3/COX6A1/COX5A/PDK3/COX7B	2.81050134306311
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	21/2614	44/9376	1.7119009529109	OSTC/MGAT2/DAD1/STT3B/DDOST/ALG2/ALG13/ALG14/MAN1A1/HEXA/MAN1C1/FUT8/ALG1/B4GALT3/STT3A/MGAT4B/MAN2A1/RPN1/B4GALT1/TUSC3/MGAT4C	2.94279082984564
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	55/2614	144/9376	1.3699736461787	FAS/TBK1/ADH5/NFKBIA/TNFRSF1A/AKT1/ALDH2/CXCL1/TRA2A/CTNNB1/CASP3/ACADVL/MAPK10/CXCL8/ADH1B/MAP2K3/ALDH3A2/IL6/SREBF1/SIRT1/NFKB1/CASP8/MYD88/MAPK8/PRKAA1/TLR4/GSK3B/IRAK4/PRKAB2/ADIPOR1/ALDH9A1/ACADM/MAPK9/FADD/C3/ACOX1/C4B/MAP3K7/TCF7/TICAM1/TRAF6/ACACB/AKT3/ACACA/TAB3/ADH1C/CXCL2/CHUK/LPIN3/MAPK12/MAPK14/PRKAB1/ALDH1B1/MAP3K5/TNF	2.78166601414667
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	53/2614	138/9376	1.37755452801526	SDHD/NDUFB5/NDUFB3/NDUFC2/COX11/NDUFV2/SDHB/NDUFA4/ATP5F1C/SDHC/NDUFA9/COX7A2L/PPA2/ATP5MC3/NDUFB8/NDUFAB1/UQCRC2/ATP6V1G1/NDUFB6/CYCS/UQCRFS1/NDUFA8/UQCRH/NDUFS4/ATP6V0E1/NDUFA7/ATP6V1C1/NDUFS3/ATP5MC1/ATP5PB/COX10/ATP6V1H/PPA1/ATP5PO/NDUFA10/NDUFB4/NDUFA5/COX15/ATP6V1E2/CYC1/ATP6V1D/NDUFA12/ATP5MC2/COX6C/ATP6V1A/ATP6V1C2/COX8A/ATP6V0A2/ATP6V0E2/COX6A1/COX5A/COX7B/ATP5MGL	2.7779926604724
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/2614	21/9376	2.04962290960761	DSEL/CHST7/CHST11/CSGALNACT2/DSE/CHST14/CHSY3/B4GALT7/B3GALT6/UST/XYLT2/CHST15	2.99379390117016
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	42/2614	105/9376	1.43473603672533	MTX2/SIAH1/TBK1/EIF2AK3/MAPK10/OPA1/CCZ1/AMFR/HIF1A/CALCOCO2/MFN1/EIF2S1/MAPK8/MAP1LC3B/NRAS/MAPK9/RHOT1/GABARAPL2/USP15/CSNK2A2/USP30/RAB7A/KRAS/CSNK2B/TOMM40/PGAM5/MUL1/MTX3/TOMM20/PHB2/TP53/BECN1/BCL2L13/SMURF2/TRAF2/TBC1D15/CCZ1B/ARIH1/RRAS/VCP/UBC/BNIP3	2.78520936904519
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	17/2614	34/9376	1.79342004590666	POLR2B/POLR1C/POLR2C/POLR2H/POLR2M/POLR2K/POLR3K/POLR1D/POLR3F/POLR2J/POLR3H/POLR1B/POLR3B/POLR2F/POLR2D/POLR3G/POLR2J3	2.88153263422476
Human Diseases	Cancer: specific types	hsa05214	Glioma	32/2614	76/9376	1.51024845971087	GADD45A/PDGFRA/PTEN/AKT1/SOS2/PIK3CA/PRKCA/CAMK2D/MAPK1/SHC3/MAP2K2/PDGFRB/CDK4/RAF1/MDM2/NRAS/BAX/MAP2K1/POLK/KRAS/GADD45B/PIK3R3/RB1/AKT3/BRAF/GADD45G/CAMK1/TP53/CALM2/E2F3/SHC2/BAK1	2.77682090908497
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	38/2614	94/9376	1.44999918605219	CEBPB/SRSF1/TBK1/FOSL1/NFKBIA/CXCL1/CASP3/JUND/MAPK10/CXCL8/TRAF3IP2/TNFAIP3/CSF3/IL6/NFKB1/CASP8/MAPK1/MAPK8/CXCL5/ELAVL1/TRAF4/HSP90AB1/GSK3B/MAPK9/FADD/MAP3K7/TRAF6/TAB3/MAPK7/CXCL2/CHUK/HSP90AA1/TRAF2/TRAF5/MAPK12/MAPK14/IL17D/TNF	2.72618748394909
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	42/2614	106/9376	1.42120079109584	PLAU/PDGFRA/AR/NFKBIA/PTEN/AKT1/CTNNB1/CDKN1B/SOS2/PIK3CA/NFKB1/MAPK1/PLAT/BCL2/CREB5/MAP2K2/PDGFRB/FGFR1/RAF1/HSP90AB1/GSK3B/MDM2/NRAS/MAP2K1/KRAS/TCF7/PIK3R3/RB1/AKT3/ERBB2/BRAF/CASP9/TP53/CHUK/HSP90AA1/NKX3-1/CREB3L4/PDPK1/E2F3/PDGFC/CDK2/SLC19A1	2.71145930292944
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	88/2614	250/9376	1.26256771231829	OSTM1/LAPTM4B/LAPTM4A/AP3S1/M6PR/OSBP/AP1S1/AP1G1/CLN5/LAMTOR3/CD164/VPS29/SLC36A4/HYAL2/VPS26A/ARL8A/BLOC1S4/ATP6V1G1/CTSK/SPG11/LAMP2/BLOC1S2/GLA/HEXA/RRAGA/ARL8B/CLTA/SCARB2/ATP6V0E1/VPS13C/NPC1/CTBS/ABCA5/ATP6V1C1/MANBA/RRAGC/CTSC/SLC11A2/VPS13A/NAGPA/SNAPIN/NEU1/AP4M1/IDUA/AP5M1/GLB1/PIKFYVE/RAB7A/STX17/AP3M1/LIPA/RRAGB/GALC/TELO2/LAMP1/BORCS8/ATP6V1H/NAGLU/SGSH/ARSB/BLOC1S6/ENTPD4/IDS/SLC15A4/LAMTOR1/ATP6V1E2/KXD1/CTNS/AP3M2/DMXL2/DTNBP1/ARSG/AP4B1/AP4S1/ATP6V1D/SLC38A9/DMXL1/ATP6V1A/ATP6V1C2/DEPTOR/ATP6V0A2/LAMTOR5/ATP6V0E2/MFSD8/ZFYVE26/MAN2B1/ASAH1/LAMTOR2	2.61620601011779
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	47/2614	122/9376	1.38181544520677	MAP3K8/NFKBIA/AKT1/NFKBIE/PAK3/MAPK10/SOS2/PIK3CA/BCL10/CDC42/NCK1/NFKB1/PPP3CC/MAPK1/MAPK8/PPP2CB/NFATC1/MAP2K2/PPP3R1/NCK2/CDK4/RAF1/MALT1/GSK3B/NRAS/PPP3CB/MAPK9/MAP2K1/PPP2R3A/FYN/KRAS/MAP3K7/PIK3R3/AKT3/PPP2R5C/CHUK/PPP2R2A/PPP2R5A/PDPK1/CBLB/PPP2CA/PTPN11/MAPK12/MAPK14/PPP2R3B/PPP2R5B/TNF	2.63918301080656
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	57/2614	154/9376	1.32759665735947	AK6/ALDH2/PTS/COQ2/NME7/NQO1/CMPK1/DLD/GCH1/ALDH3A2/NADK2/RFK/RDH11/CPOX/NFS1/BCAT1/ALAS1/CMPK2/MOCS2/MAT2A/PANK3/HSD17B6/GGH/HMBS/NME3/COQ5/SHMT2/CTPS1/GSS/MTHFD2L/UGP2/NME1/LIPT1/NADK/RDH12/ALAD/PANK2/COX10/OXSM/PHOSPHO2/MTHFD2/NMNAT1/MTHFD1L/EARS2/COX15/COQ6/MTHFD1/AK3/ADSL/TPK1/FECH/NMNAT3/PANK1/AFMID/ALDH1B1/RGN/GCLC	2.54852037387945
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	32/2614	78/9376	1.4715241402311	CASP3/MAPK10/GNAI3/CXCL8/CASP7/IL6/GNAI1/NFKB1/MYD88/MAPK1/MAPK8/TLR4/CXCL5/CASP1/IRAK4/MAPK9/CFL2/IL1A/IRF1/C3/C1S/C4B/TICAM1/TRAF6/CALM2/MAPK12/MAPK14/IL23A/ITGA5/C1R/CFL1/TNF	2.59990398024686
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	53/2614	142/9376	1.33875017511342	VCAM1/TXN/DUSP1/MGST1/ACTG1/SUMO1/SDC4/TNFRSF1A/AKT1/SUMO2/CTNNB1/MGST3/MAPK10/NQO1/PIK3CA/MMP2/ITGAV/SDC2/GSTO1/ARHGEF2/NFKB1/PLAT/MAPK8/BCL2/GSTM3/PRKAA1/CAV2/PTK2/HSP90AB1/MAPK9/SUMO4/IL1A/IL1R1/MAP3K7/GSTA4/PIK3R3/KEAP1/GSTM2/AKT3/BMPR1A/GSTT2B/MAPK7/TP53/CHUK/HSP90AA1/ACVR1/CALM2/GSTM5/MAPK12/MAPK14/MAP3K5/TNF/KLF2	2.52888809576459
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	49/2614	130/9376	1.35196280383733	COL3A1/COL4A1/GNG4/NFKBIA/COL1A2/AKT1/VEGFC/MAPK10/GNAI3/SOS2/PIK3CA/ADCY3/MMP2/COL4A5/PRKCA/ATF2/GNAI1/NFKB1/GNB2/VEGFB/MAPK1/SHC3/MAPK8/PLCB3/COL4A4/CREB5/MAP2K2/COL4A2/RAF1/ATF6B/NRAS/MAPK9/GNG5/MAP2K1/COL4A3/KRAS/PIK3R3/GNG12/AKT3/COL4A6/CREB3L4/COL1A1/ACTA2/EDNRB/MAPK12/MAPK14/SHC2/ADCY6/GNG10	2.51242060766563
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	16/2614	33/9376	1.73907398390949	SEC22B/BET1/VAMP5/STX18/VAMP3/GOSR2/BNIP1/STX7/GOSR1/STX17/STX6/VTI1A/STX11/STX4/VAMP4/SNAP23	2.64425026835935
Human Diseases	Cancer: specific types	hsa05218	Melanoma	30/2614	73/9376	1.47404387334794	GADD45A/PDGFRA/FGF2/PTEN/AKT1/PIK3CA/FGF7/MAPK1/MAP2K2/PDGFRB/FGFR1/CDK4/RAF1/MDM2/NRAS/BAX/MAP2K1/POLK/KRAS/GADD45B/PIK3R3/RB1/AKT3/BRAF/GADD45G/TP53/HGF/E2F3/BAK1/PDGFC	2.52795479854586
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	64/2614	178/9376	1.28965037009018	MYC/BAMBI/CACYBP/RYK/SFRP4/PRICKLE2/WNT2/SIAH1/SERPINF1/FOSL1/DKK1/CCND2/SKP1/LZTS2/CTNNB1/MAPK10/FZD2/PRKCA/TLE4/CAMK2D/INVS/SIRT1/PPP3CC/ROR1/MAPK8/NFATC1/PLCB3/CBY1/RSPO3/FZD1/PPP3R1/SMAD4/FZD8/GSK3B/PRICKLE1/PPP3CB/MAPK9/CSNK2A2/SFRP2/WNT6/CSNK2B/CCAR2/CUL1/CTNNBIP1/MAP3K7/TCF7/DVL3/BTRC/TP53/LRP6/TBL1XR1/DVL2/PSEN1/PPARD/RBX1/CSNK1A1/ZNRF3/DAAM1/VANGL1/VANGL2/FRAT2/CXXC4/FZD10/APCDD1	2.4257063934728
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	10/2614	18/9376	1.99268893989628	LMBRD1/THAP11/MMADHC/PRDX1/ZNF143/ABCD4/MTRR/MMAA/ZNF76/MMACHC	2.6209501566194
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	22/2614	51/9376	1.54726435333123	ACTG1/SEC61B/KDELR2/ADCY3/PRKCA/ATP6V1G1/SEC61G/ARF1/ATP6V0E1/ATP6V1C1/PDIA4/KDELR3/ERO1A/ATP6V1H/SLC12A2/ATP6V1E2/ATP6V1D/ATP6V1A/ATP6V1C2/KDELR1/ATP6V0A2/ATP6V0E2	2.43645657431978
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	23/2614	54/9376	1.52772818725382	MDH1/LDHB/APIP/AMD1/CDO1/BCAT1/MAT2A/ENOPH1/MTAP/MRI1/GSS/GOT1/MDH2/LDHA/SRM/BHMT2/KYAT3/ADI1/AHCYL2/LACC1/CISD1/BHMT/GCLC	2.41798425597841
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	17/2614	37/9376	1.64800760975206	UAP1/GALK2/PGM3/GFPT2/PGM2/UXS1/TGDS/UGP2/CMAS/GNPNAT1/GFPT1/FPGT/PGM1/GALE/NANP/GNE/GMDS	2.45545300682866
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	24/2614	57/9376	1.51024845971087	SCP2/HADHB/ACADVL/ELOVL5/HSD17B4/CBR4/ELOVL6/HACD1/ACSL1/HADH/HACD3/ECHS1/ACADM/ELOVL4/ACAA2/ACOX1/ACAT2/OXSM/ACACA/ACSL4/ACSL5/ACAT1/ELOVL3/MCAT	2.40234469312001
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	40/2614	105/9376	1.36641527307174	VCAM1/PLAU/GADD45A/NFKBIA/TNFRSF1A/CXCL1/CXCL8/CXCL12/BCL10/CYLD/TNFAIP3/UBE2I/NFKB1/MYD88/BCL2/ATM/TLR4/MALT1/IRAK4/TRIM25/CSNK2A2/IL1R1/CSNK2B/GADD45B/MAP3K7/TICAM1/TRAF6/TAB3/GADD45G/CXCL2/CHUK/RELB/TRAF2/TNFSF14/TRAF1/TRAF5/PIDD1/EDA/TNF/ERC1	2.34750093230816
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	35/2614	90/9376	1.3948822579274	IFNGR1/IFNGR2/NFKBIA/PTEN/AKT1/NFKBIE/PIK3CA/MAP2K3/HIF1A/NFKB1/MYD88/PPP3CC/MAPK1/NFATC1/MAP2K2/TLR4/PPP3R1/RAF1/STAT1/NRAS/PPP3CB/MAP2K1/CSNK2A2/KRAS/CSNK2B/STAT3/PIK3R3/TICAM1/TRAF6/AKT3/CHUK/BATF2/PTPN11/MAPK12/MAPK14	2.34032074862994
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	14/2614	29/9376	1.73157797535815	FAT4/YAP1/MOB1A/FRMD6/TEAD3/WTIP/SAV1/STK3/TEAD2/MOB1B/RASSF1/WWTR1/AJUBA/DCHS2	2.45315136783291
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	39/2614	103/9376	1.35812391825941	FAS/IFNGR1/IFNGR2/NFKBIA/TNFRSF1A/CALR/AKT1/MAPK10/GNAI3/PIK3CA/CXCL8/SERPINE1/BDKRB2/IL6/GNAI1/NFKB1/CASP8/MYD88/MAPK1/MAPK8/PPP2CB/PLCB3/TLR4/IRAK4/MAPK9/FADD/C3/PIK3R3/TICAM1/TRAF6/GNAL/AKT3/CHUK/PPP2R2A/PPP2CA/MAPK12/MAPK14/TGFB3/TNF	2.2721796010837
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	45/2614	122/9376	1.32301478796393	SOCS2/JUNB/SOCS3/AKT1/SOCS1/MAPK10/GNAI3/SOS2/PIK3CA/ADCY3/PRKCA/MAP2K3/ATF2/GNAI1/MAPK1/SHC3/MAPK8/PLCB3/CREB5/MAP2K2/PTK2/RAF1/STAT1/ATF6B/GSK3B/NRAS/MAPK9/MAP2K1/CACNA1C/KRAS/CACNA1D/STAT3/PIK3R3/AKT3/BCAR1/ITPR3/CREB3L4/IRS1/GHR/CRKL/MAPK12/STAT5B/MAPK14/SHC2/ADCY6	2.23274137108838
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	52/2614	144/9376	1.29524781093259	MYC/ID3/FGF2/WNT2/ID2/AKT1/ID4/KLF4/CTNNB1/FZD2/MEIS1/PIK3CA/SMARCAD1/TBX3/ID1/PCGF5/MAPK1/MAP2K2/FZD1/FGFR1/SMAD4/LEFTY2/PCGF2/RAF1/FZD8/GSK3B/NRAS/ACVR1B/MAP2K1/WNT6/KRAS/STAT3/SKIL/TCF7/PIK3R3/DVL3/AKT3/PCGF1/BMPR1A/LIF/ACVR1/DVL2/PCGF3/PCGF6/BMI1/TCF3/MAPK12/MAPK14/IL6ST/SMAD9/FZD10/POU5F1	2.21983595292541
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	18/2614	41/9376	1.57471028421072	MYC/CXCL8/MMP2/MAPK1/MAP2K2/CDK4/RAF1/MDM2/NRAS/MAP2K1/KRAS/RB1/ERBB2/BRAF/TP53/RASSF1/THBS1/E2F3	2.29289719257197
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	37/2614	98/9376	1.35421513670503	MARCKSL1/ARPC1A/AKT1/GSN/ARPC3/PIK3CA/PRKCA/CDC42/ACTR3/WASF3/MAPK1/ARF6/RAF1/ARPC5L/CFL2/PRKCD/MAP2K1/WASF1/PIK3R3/AKT3/PIP5K1A/BIN1/PLD1/AMPH/ASAP3/CRKL/PLA2G4A/ACTR2/SPHK1/PLA2G4C/ARPC1B/ARPC4/ACTR3C/MARCKS/CFL1/ACTR3B/LIMK2	2.19156227683548
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	33/2614	86/9376	1.37634561662604	MYC/AKT1/PAK3/MAPK10/CDKN1B/SOS2/PIK3CA/PRKCA/CAMK2D/ABL1/NCK1/MAPK1/SHC3/MAPK8/MAP2K2/NCK2/PTK2/RAF1/GSK3B/NRAS/MAPK9/MAP2K1/KRAS/ELK1/PIK3R3/AKT3/ERBB2/BRAF/CBLB/CRKL/STAT5B/SHC2/GAB1	2.17986238456709
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	31/2614	80/9376	1.38990053557766	PDGFRA/FGF2/PTEN/AKT1/EIF4E/SOS2/PIK3CA/PRKCA/GAS6/IL6/MAPK1/SHC3/BCL2/MAP2K2/PDGFRB/RAF1/GSK3B/NRAS/BAX/MAP2K1/KRAS/STAT3/PIK3R3/AKT3/ERBB2/BRAF/NF1/HGF/SHC2/GAB1/PDGFC	2.17746716258467
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	28/2614	71/9376	1.41452848691229	MYC/PDGFRA/GLS/PTEN/AKT1/LDHB/PIK3CA/PFKM/HIF1A/MAPK1/MAP2K2/PDGFRB/PDHB/FGFR1/RAF1/NRAS/MAP2K1/PGAM1/KRAS/PIK3R3/PDHA1/AKT3/LDHA/ERBB2/TIGAR/TP53/SIRT6/PDK1	2.17984800971492
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	64/2614	184/9376	1.2475965536742	TRPC4/RYK/UNC5C/NRP1/MYL12B/PAK3/BOC/GNAI3/PIK3CA/CXCL12/PRKCA/CDC42/ENAH/TRPC1/CAMK2D/ABL1/GNAI1/ROBO1/NCK1/PPP3CC/MAPK1/SEMA4C/RGMA/PPP3R1/EFNA4/NCK2/EFNB1/PTK2/RAF1/SEMA4B/GSK3B/ABLIM3/NRAS/MYL12A/PPP3CB/CFL2/FYN/KRAS/NEO1/SRGAP1/EFNA5/GDF7/PIK3R3/EPHA2/UNC5B/EPHA6/PLXNC1/SLIT3/ARHGEF12/NTN1/PDPK1/PARD3/SMO/RRAS/PLXNA1/TRPC6/PTPN11/ROBO2/SSH1/PLXNA2/ABLIM2/PARD6G/CFL1/LIMK2	2.10886775134557
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	17/2614	39/9376	1.56349439899555	MTHFS/GCSH/ALDH1L2/DLD/ATIC/MAT2A/GART/SHMT2/MTHFD2L/MTHFD2/MTHFD1L/BHMT2/MTHFD1/AHCYL2/SARDH/CHDH/BHMT	2.19239637002019
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	30/2614	78/9376	1.37955388146666	ACTG1/ARPC1A/CTNNB1/ARPC3/PIK3CA/CDC42/DNM1/ACTR3/SHC3/CLTA/CAV2/PTK2/ELMO2/ARPC5L/CTTN/VCL/ARHGAP10/WASF1/PIK3R3/BCAR1/WASL/CRKL/ACTR2/ARPC1B/SHC2/ARPC4/GAB1/ITGA5/ACTR3C/ACTR3B	2.09279560248954
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	40/2614	109/9376	1.31627159332599	SOCS3/NFKBIA/SLC27A3/TNFRSF1A/PTEN/AKT1/PPP1CB/PPP1CC/MAPK10/PIK3CA/IL6/SREBF1/GFPT2/OGT/NFKB1/MLX/MAPK8/CREB5/PRKAA1/PPP1R3C/NR1H2/GSK3B/PYGL/PRKAB2/MAPK9/CRTC2/PRKCD/GFPT1/STAT3/PIK3R3/ACACB/AKT3/PPP1R3D/CREB3L4/PDPK1/IRS1/PTPN11/PPP1R3B/PRKAB1/TNF	2.06492698868519
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	24/2614	60/9376	1.43473603672533	AKT1/PIK3CA/PRKCA/CDC42/MAPKAPK2/PPP3CC/MAPK1/MAP2K2/PPP3R1/PTK2/RAF1/NRAS/PPP3CB/MAP2K1/KRAS/PIK3R3/AKT3/CASP9/PLA2G4A/SPHK1/PLA2G4C/MAPK12/MAPK14/SHC2	2.10032921666401
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	55/2614	157/9376	1.25653633789638	CEBPB/DUSP5/CALR/CD47/ADAM17/CASP3/CASP7/ITGAV/ODC1/PBX1/ATP2A2/GAS6/CAMK2D/ITGB5/HIF1A/MAPKAPK2/SIRT1/GULP1/UQCRFS1/MAPK1/TMEM30A/NFATC1/PANX1/MAP2K2/ABCA1/PTK2/ATP11B/NR1H2/CASP1/DUSP7/LRP1/ANO6/MAP2K1/SLC16A1/XKR6/DUSP8/RAB7A/LIPA/ANO4/EPOR/ARNT/BCAR1/PROS1/ADAM10/MEGF10/PPARD/ADAM9/CRKL/SPHK1/PTPN11/MAPK12/MAPK14/THBS1/ATP11C/PPARG	2.01538330267139
NA	NA	hsa04519	Cadherin signaling	130/2614	404/9376	1.1541812176627	PCDH18/RYK/VIM/PDGFRA/PRICKLE2/WNT2/ACTG1/NFKBIA/ARPC1A/PPP1CB/GABRE/FAT4/PPP1CC/CTNNB1/YAP1/ARPC3/MOB1A/MAPK10/FZD2/KRT10/PCDHB15/PCDHGA12/TEAD3/WTIP/CDC42/ENAH/SAV1/MAP2K3/MYO1B/STK3/PCDHGA10/ACTR3/NFKB1/MAPK1/MAPK8/MAP2K2/TEAD2/PDGFRB/FZD1/ACTN1/FGFR1/APH1B/YWHAQ/PCDHB14/PTK2/RAF1/FZD8/KRT23/NCSTN/PCDHGB6/GABRA2/GSK3B/ARPC5L/PRICKLE1/NRAS/MAPK9/YWHAG/VCL/PCDHGA6/ABI2/BRK1/MAP2K1/PCDHGA9/PCDHGB5/WNT6/KRAS/WASF1/PCDHGA5/PCDHA10/TCF7/PCDHGC3/DVL3/PCDHGB7/NCKAP1/ERBB2/PCDHB4/TMC1/PSENEN/LRP6/CHUK/PCDHGA3/ADAM10/DVL2/PSEN1/MOB1B/MPDZ/MYO1E/PCDHB7/WWTR1/LHFPL3/AJUBA/PCDHGA4/PCDHB16/CSNK1A1/RRAS/ERBIN/DAAM1/ACTR2/VANGL1/TMIE/PCDHB3/MAPK12/LIMA1/PCDHB5/PCDH10/ARPC1B/MAPK14/PCDHB10/KRT34/VANGL2/PCDHB13/ARPC4/FZD10/GJA1/PCDHGB2/PCDHGA8/PCDHB12/CDH2/PCDHGA11/ACTR3C/CDH3/PCDH9/PCDHGA1/ACTR3B/PCDHA12/DCHS2/FAT1/PCDHGB3/CDH15/KRT85	1.96960150729084
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	10/2614	20/9376	1.79342004590666	HSD17B7/MSMO1/LSS/LIPA/CYP27B1/CYP51A1/LBR/SQLE/SOAT2/CYP2R1	2.20838051532856
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	49/2614	138/9376	1.27358814854241	SOCS2/SOCS3/AKT1/PPP1CB/SOCS1/PPP1CC/EIF4E/MAPK10/SOS2/PIK3CA/RHOQ/SREBF1/RHEB/MAPK1/SHC3/MAPK8/MAP2K2/PRKAA1/PHKG1/PPP1R3C/RAF1/GSK3B/MKNK2/PYGL/PRKAB2/NRAS/MAPK9/MAP2K1/KRAS/ELK1/PIK3R3/ACACB/AKT3/ACACA/BRAF/TSC1/PPP1R3D/PRKAR1A/CALM2/PPP1R3F/SOCS4/PDPK1/CBLB/PHKA2/IRS1/CRKL/PPP1R3B/PRKAB1/SHC2	2.01302278809468
Genetic Information Processing	Translation	hsa03010	Ribosome	75/2614	222/9376	1.21177030128828	MRPL32/RPL22L1/MRPL42/MRPL50/MRPL18/MRPL3/RPS7/MRPL39/MRPS22/MRPL13/MRPL44/MRPL17/MRPL47/MRPS28/RPS10/RPL27/MRPS35/MRPS14/MRPL15/MRPS30/DAP3/RPS21/RPL23A/MRPS23/RPL7A/MRPL35/MRPL45/MRPL9/MRPS25/MRPL22/MRPS26/MRPL14/RPL32/MRPL11/MRPS7/MRPL36/MRPL16/MRPL19/MRPL34/MRPL10/MRPS11/RPS15A/RSL24D1/RPL30/MRPS15/MRPS2/MRPS27/FAU/RPL26/MRPL4/MRPL43/RPL26L1/MRPS18C/RPS13/MRPS10/MRPL12/RPL36A/MRPS17/RPS25/MRPL30/RPS18/MRPS16/RPL14/RPL17/MRPL21/MRPS33/RPS23/MRPL53/RPL10A/RPL24/RPLP1/RPL3/RPS24/MRPL51/RPL9	1.9853493329215
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	15/2614	34/9376	1.58242945227058	NFIL3/SKP1/BHLHE40/NR1D2/PRKAA1/PRKAB2/PER1/BHLHE41/CRY1/CUL1/BTRC/PER2/RBX1/PRKAB1/NPAS2	2.11525973223113
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	62/2614	181/9376	1.22864135741671	CEBPB/RIPK2/IFNGR1/IFNGR2/NFYB/TNFRSF1A/AKT1/CASP3/MAPK10/HSPA9/HSPD1/BCL10/CAMK2D/IL6/LAMP2/CYCS/NFKB1/CASP8/MYD88/PPP3CC/MAPK1/MAPK8/BCL2/BID/TLR4/PPP3R1/PIK3C3/RAF1/MALT1/STAT1/IRAK4/PPP3CB/MAPK9/IL1A/BAX/FADD/C3/RAB7A/CASP10/PLK3/HLA-DOB/LAMP1/CYP27B1/IRAK2/TRAF6/ATP6V1H/AKT3/CASP9/RFX5/CALM2/NFYA/ARHGEF12/SPHK1/MAPK12/MAPK14/IL23A/PLA2R1/RFXAP/ATP6V0A2/IL10RB/TGFB3/TNF	1.93116355614511
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	69/2614	205/9376	1.20727788456155	GTF2B/NFKBIA/HLA-F/GTF2H2/CCND2/GTF2A2/GSN/TBPL1/RANBP1/CASP3/IRF7/CDKN1B/PIK3CA/CDC42/ATF2/KAT2A/HDAC8/MAPKAPK2/CHEK1/HDAC1/HDAC3/NFKB1/CASP8/GTF2H1/MAPK1/VDAC3/CREB5/GTF2H3/GTF2A1/ACTN1/YWHAQ/CDK4/ATF6B/SP100/MDM2/NRAS/YWHAG/BAX/RBL2/PMAIP1/HLA-B/C3/SKP2/KRAS/UBE3A/EGR3/STAT3/RASA2/USP7/PIK3R3/RB1/KAT2B/CDKN2B/TP53/GTF2E1/DDX3X/DNAJA3/GTF2H2C/TRAF2/EIF2AK2/CREB3L4/TRAF1/HDAC9/TRAF5/STAT5B/IL6ST/TBP/BAK1/CDK2	1.86561660299642
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	14/2614	32/9376	1.56924254016832	ATG5/ATG4C/ATG16L1/WIPI1/ATG101/PPP2CB/PIK3C3/GABARAPL2/PIK3R4/ATG2B/ATG3/BECN1/PPP2CA/WIPI2	2.00542658946306
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	27/2614	71/9376	1.36400961237971	NFKBIA/CXCL1/ADAM17/CASP3/MAPK10/CXCL8/CDC42/ATP6V1G1/JAM3/NFKB1/MAPK8/ATP6V0E1/ATP6V1C1/MAPK9/ATP6V1H/CXCL2/CHUK/ADAM10/ATP6V1E2/ATP6V1D/PTPN11/MAPK12/ATP6V1A/MAPK14/ATP6V1C2/ATP6V0A2/ATP6V0E2	1.91418841916864
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	16/2614	38/9376	1.51024845971087	UAP1/GNPDA2/GALK2/PGM3/GFPT2/PGM2/HEXA/GNPDA1/UXS1/UGP2/GNPNAT1/GFPT1/FPGT/PGM1/GALE/GNE	1.95950967667354
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	23/2614	59/9376	1.39825969680858	NT5E/NME7/CMPK1/DUT/DCTD/CMPK2/ENPP1/NME3/DTYMK/CTPS1/UCKL1/NME1/RRM2B/NUDT2/HDDC2/DCTPP1/ENTPD4/CDADC1/DCK/UCK2/ENTPD3/UCK1/NT5C2	1.90789804709732
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	23/2614	59/9376	1.39825969680858	MGST1/GGT5/MGST3/ODC1/GSTO1/GPX8/GSTK1/GSTM3/GSR/PRDX6/GSS/RRM2B/LAP3/GSTA4/TXNDC12/GGCT/GSTM2/LANCL1/GSTT2B/SRM/GSTM5/GGT7/GCLC	1.90789804709732
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	22/2614	56/9376	1.40911575035523	GAS1/CUL3/CCND2/BOC/EFCAB7/MOSMO/CSNK1G3/BCL2/GSK3B/EVC/HHIP/CSNK1G2/CUL1/SPOP/GLI1/SPOPL/BTRC/SMURF2/EVC2/SMO/CSNK1A1/GLI3	1.90911945537765
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	10/2614	21/9376	1.70801909133967	CSAD/ALDH2/ALDH3A2/BCAT1/AASDHPPT/ENPP1/PANK3/PANK2/PANK1/ALDH1B1	2.01945214625429
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	33/2614	90/9376	1.31517470033155	SOD2/CAT/AKT1/ATG5/EIF4E/PIK3CA/ADCY3/ATF2/SIRT1/RHEB/NFKB1/ATG101/CREB5/STK11/PRKAA1/EHMT1/ATF6B/PRKAB2/ADIPOR1/NRAS/BAX/SESN3/KRAS/SESN1/PIK3R3/AKT3/TSC1/TP53/CREB3L4/IRS1/PRKAB1/ADCY6/PPARG	1.86792360462231
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	20/2614	50/9376	1.43473603672533	L3HYPDH/ALDH2/OAT/P4HA3/AMD1/ODC1/CNDP2/ALDH3A2/ALDH18A1/GOT1/ALDH9A1/SAT2/LAP3/CKMT2/SRM/PYCR2/CKB/MAOB/ALDH1B1/AZIN2	1.91630125941379
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/2614	13/9376	1.93137543405332	RAD50/LIG4/XRCC4/DCLRE1C/PRKDC/FEN1/XRCC5	2.08924701272147
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	29/2614	78/9376	1.33356875208444	MINPP1/PTEN/PIK3CA/MTMR2/INPP1/MTM1/PLCB3/PPIP5K2/PIK3C3/OCRL/PIKFYVE/IP6K2/PI4KB/MTMR4/ITPKA/ALDH6A1/SACM1L/PIP5K1A/ITPKC/IPMK/INPP5E/MTMR6/IMPA2/IP6K3/IPPK/INPP5F/SYNJ1/PIP4K2C/PI4K2B	1.83924141361087
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	27/2614	72/9376	1.34506503442999	TBK1/NFKBIA/ATG5/TANK/MAPK10/IRF7/CXCL8/CYLD/NFKB1/CASP8/AZI2/MAPK8/SIKE1/MAPK9/TRIM25/FADD/CASP10/MAP3K7/DHX58/TRAF6/CHUK/DDX3X/TRAF2/MAPK12/MAPK14/ISG15/TNF	1.8273982230048
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	13/2614	30/9376	1.5542973731191	PIGF/PIGK/PIGG/PIGL/PIGP/PIGN/PIGH/PIGA/PIGV/PGAP1/PIGO/PGAP2/PIGB	1.89056409672321
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	17/2614	42/9376	1.45181622763872	CAT/ALDH2/AOX1/DLD/ALDH3A2/AADAT/DLST/HADH/ALDH9A1/ECHS1/ACAT2/GCDH/KYAT3/ACAT1/AFMID/MAOB/ALDH1B1	1.8245401248909
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	17/2614	42/9376	1.45181622763872	SLC39A14/ATG5/SLC3A2/PRNP/VDAC3/VDAC2/ACSL1/MAP1LC3B/SLC11A2/GSS/SAT2/LPCAT3/ACSL4/TP53/ACSL5/GCLC/SLC39A8	1.8245401248909
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	41/2614	117/9376	1.25692686978073	MORF4L2/ACTG1/ACTL6A/SMARCE1/MBD2/MEAF6/ACTR6/HDAC1/MTA3/BCL7C/GATAD2B/PHF6/DPF2/EPC2/MRGBP/MTA1/SS18L1/ARID2/UCHL5/PBRM1/INO80/ARID1B/PHF10/CDK2AP1/MCRS1/SMARCD3/BCL7B/SMARCB1/BICRA/SS18/INO80C/VPS72/CHRAC1/ACTR8/BICRAL/YEATS4/MTA2/CDK2AP2/CHD3/YY2/ACTR5	1.73868641652616
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/2614	19/9376	1.69902951717473	HYAL2/HEXA/IDUA/GLB1/NAGLU/SGSH/ARSB/IDS/HPSE	1.89629040235012
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	26/2614	70/9376	1.33225489124495	SOCS3/NFKBIA/TNFRSF1A/AKT1/NFKBIE/MAPK10/NFKB1/MAPK8/ACSL1/STK11/PRKAA1/PRKAB2/ADIPOR1/MAPK9/STAT3/ACACB/AKT3/ACSL4/ACSL5/CHUK/TRAF2/IRS1/PTPN11/PRKAB1/POMC/TNF	1.73476130190732
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	57/2614	170/9376	1.20264638372564	ACTG1/MYL12B/ARPC1A/RAP2C/ARPC3/HSPA4/MAPK10/TUBA3D/YBX3/CDC42/PCNA/CLDN20/ARHGEF2/JAM3/ACTR3/MAPK8/PPP2CB/STK11/PRKAA1/ACTN1/CDK4/ARPC5L/CLDN10/PRKAB2/MYL12A/RAB13/MAPK9/RAB8A/NEDD4/CTTN/CACNA1D/WHAMM/MICALL2/RAB8B/CLDN23/RUNX1/CLDN12/ERBB2/RAP1A/PPP2R2A/TUBA1A/MPDZ/PPP2CA/PARD3/CD1D/LLGL1/ACTR2/ARPC1B/DLG2/PRKAB1/ARPC4/ACTR3C/MAP3K5/OCLN/MPP4/PARD6G/ACTR3B	1.65778681067053
NA	NA	hsa04518	Integrin signaling	52/2614	154/9376	1.21114081022268	VCAM1/LAMA2/LAMB1/PDGFRA/ACTG1/COL4A1/COL1A2/AKT1/CCND2/VEGFC/CTNNB1/PIK3CA/COL4A5/ITGAV/THBS2/COL6A1/CDC42/COL6A2/ITGB5/ITGAE/VEGFB/COL4A4/COL4A2/PDGFRB/ACTN1/NCK2/PTK2/LAMA1/GSK3B/ITGA6/VCL/COL4A3/C3/PIK3R3/FGG/AKT3/ERBB2/FGB/COL4A6/COL1A1/THBS3/FREM1/PARVA/HGF/TNC/NPNT/THBS1/LAMC1/ITGA5/PDGFC/COMP/THBS4	1.64255844655781
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	35/2614	99/9376	1.268074779934	AKT1/MAPK10/CDKN1B/SOS2/PIK3CA/ADCY3/MMP2/MAPK1/SHC3/MAPK8/BCL2/MAP2K2/CDK4/PTK2/RAF1/MDM2/NRAS/MAPK9/BAX/MAP2K1/ESR1/JAG1/KRAS/PIK3R3/RB1/AKT3/ERBB2/BRAF/TP53/DLL1/MAPK12/MAPK14/E2F3/SHC2/ADCY6	1.66713444157142
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	21/2614	55/9376	1.36952076232872	CERS2/DEGS1/SPTLC1/GLA/HEXA/ACER3/CERS5/SGPP1/UGCG/SGMS2/NEU1/GLB1/CERS4/GALC/KDSR/CERS6/SPHK1/SGPL1/SPTLC2/ASAH1/SMPD2	1.7087942838031
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/2614	28/9376	1.53721718220571	HADHB/ELOVL5/ELOVL6/HACD1/MBLAC2/HADH/HACD3/ECHS1/ELOVL4/ACAA2/ACOT2/ELOVL3	1.76998833830792
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	13/2614	31/9376	1.50415874817978	MDH1/CAT/GCSH/DLD/PGP/MCEE/ACO1/SHMT2/PCCA/MDH2/ACAT2/ACAT1/AFMID	1.74807212743535
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/2614	31/9376	1.50415874817978	HSPA5/SRP9/SEC61B/SPCS3/SRP54/SRPRA/SRPRB/SEC11A/SPCS1/SEC61G/IMMP2L/IMMP1L/SPCS2	1.74807212743535
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	33/2614	93/9376	1.27274970999827	MAPK10/SOS2/ADCY3/MMP2/PRKCA/CDC42/MAP2K3/CAMK2D/MAPK1/MAPK8/PLCB3/MAP2K2/RAF1/NRAS/MAPK9/PRKCD/MAP2K1/CACNA1C/KRAS/CACNA1D/ELK1/MAPK7/MAP3K4/PLD1/CALM2/ITPR3/PLA2G4A/PLA2G4C/MAPK12/MAPK14/EGR1/ADCY6/MMP14	1.64347250630158
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	8/2614	17/9376	1.68792474908862	PAPSS1/SEPHS2/TXNRD1/SEPHS1/MARS2/KYAT3/PSTK/SEPSECS	1.76502766850899
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	50/2614	150/9376	1.19561336393777	MYC/GADD45A/FGF2/WNT2/AKT1/CTNNB1/FZD2/CDKN1B/SOS2/PIK3CA/FGF7/MAPK1/SHC3/MLH1/BCL2/MAP2K2/FZD1/SMAD4/RAF1/FZD8/GSK3B/NRAS/BAX/MAP2K1/POLK/WNT6/KRAS/GADD45B/TCF7/PIK3R3/DVL3/RB1/AKT3/ERBB2/BRAF/GADD45G/CDKN2B/TP53/LRP6/DVL2/CSNK1A1/HGF/FRAT2/E2F3/SHC2/GAB1/FZD10/BAK1/TGFB3/CDK2	1.50154472509644
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	34/2614	98/9376	1.24441390940462	PTEN/PIK3CA/PRKCA/MTMR2/PIP4P2/INPP1/MTM1/PLCB3/PPIP5K2/PIK3C3/OCRL/PIKFYVE/IP6K2/PI4KB/PIK3R3/MTMR4/ITPKA/SACM1L/PIP5K1A/ITPKC/IPMK/INPP5E/PIP4P1/MTMR6/IMPA2/IP6K3/CALM2/ITPR3/IPPK/INPP5F/SYNJ1/CDS2/PIP4K2C/PI4K2B	1.51221178396763
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	23/2614	63/9376	1.30948130336042	GADD45A/WNT2/BMP2/CTNNB1/FZD2/FZD1/FZD8/GSK3B/BAX/HHIP/POLK/WNT6/GADD45B/TCF7/DVL3/GLI1/GADD45G/TP53/DVL2/SMO/GLI3/FZD10/BAK1	1.53235975374518
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	76/2614	238/9376	1.14537750831013	RPL22L1/OAS1/NRP1/TBK1/RPS7/NFKBIA/OAS2/TNFRSF1A/RPS10/ADAM17/CGAS/MAPK10/RPL27/CFD/PIK3CA/CXCL8/PRKCA/RPS21/RPL23A/STAT2/CSF3/IL6/NFKB1/RPL7A/MYD88/MAPK1/MAPK8/TLR4/RPL32/MX1/STAT1/CASP1/IRAK4/ACE2/RPS15A/RSL24D1/MAPK9/RPL30/FAU/RPL26/C3/C1S/STAT3/C4B/RPL26L1/MAP3K7/RPS13/PIK3R3/FGG/TRAF6/MASP1/RPL36A/CHUK/RPS25/MX2/FGB/RPS18/RPL14/EIF2AK2/RPL17/IFNAR2/RPS23/C7/AGTR1/RPL10A/MAPK12/RPL24/MAPK14/IL6ST/RPLP1/RPL3/ISG15/C1R/RPS24/RPL9/TNF	1.41241060342848
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	49/2614	148/9376	1.18753489526252	MYC/GADD45A/FGF2/WNT2/PTEN/AKT1/CTNNB1/FZD2/SOS2/PIK3CA/FGF7/MAPK1/SHC3/MAP2K2/FZD1/FGFR1/CDK4/RAF1/FZD8/GSK3B/NRAS/BAX/MAP2K1/PGR/ESR1/POLK/JAG1/WNT6/KRAS/GADD45B/TCF7/PIK3R3/DVL3/RB1/AKT3/ERBB2/BRAF/GADD45G/NCOA1/TP53/LRP6/DLL1/DVL2/CSNK1A1/FRAT2/E2F3/SHC2/FZD10/BAK1	1.42974965897399
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	34/2614	99/9376	1.23184407193589	PDGFRA/CHPT1/AKT1/MAPK10/SOS2/PIK3CA/PRKCA/SLC22A3/HIF1A/RHEB/WASF3/MAPK1/MAPK8/MAP2K2/PDGFRB/SLC22A4/RAF1/NRAS/MAPK9/MAP2K1/LYPLA1/KRAS/WASF1/PIK3R3/AKT3/PIP5K1A/TSC1/PLD1/CHKA/PDPK1/PLA2G4A/PLA2G4C/PDGFC/SLC44A3	1.44181872496039
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	41/2614	122/9376	1.20541347347824	MYC/ACTG1/AKT1/CTNNB1/PIK3CA/ITGAV/PRKCA/MED30/ATP2A2/MED13L/PFKM/KAT2A/HIF1A/HDAC1/RHEB/HDAC3/MAPK1/PLCB3/MAP2K2/RAF1/STAT1/GSK3B/MDM2/NRAS/ATP1A1/MAP2K1/MED17/ESR1/KRAS/MED14/MED13/PIK3R3/AKT3/KAT2B/NCOA1/CASP9/TP53/MED27/PDPK1/SLC16A2/DIO3	1.41985809165202
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	74/2614	232/9376	1.14407830514735	TMSB4X/PDGFRA/FGF2/ACTG1/BDKRB1/MYL12B/ARPC1A/AKT1/PPP1CB/GSN/PAK3/PPP1CC/ARPC3/SOS2/PIK3CA/BDKRB2/ITGAV/CXCL12/CDC42/ENAH/ITGB5/PFN2/FGF7/ACTR3/ITGAE/PPP1R12B/MAPK1/MAP2K2/PDGFRB/ACTN1/FGFR1/PTK2/RAF1/GNA12/ARPC5L/NRAS/MYL12A/CFL2/ITGA6/VCL/ABI2/BRK1/MAP2K1/PIKFYVE/KRAS/WASF1/ARHGEF1/PIK3R3/NCKAP1/GNG12/AKT3/FGD1/BRAF/PIP5K1A/BCAR1/WASL/ARHGEF12/PFN1/RRAS/C7/CRKL/ACTR2/GNA13/SSH1/ARPC1B/ARPC4/ITGA5/PIP4K2C/ARHGEF4/ACTR3C/PDGFC/CFL1/ACTR3B/LIMK2	1.381577721416
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	8/2614	18/9376	1.59415115191703	CBR4/ACSL1/OXSM/ACACB/ACACA/ACSL4/ACSL5/MCAT	1.56870948399529
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	32/2614	93/9376	1.23418153696802	SNAI2/ACTG1/MYL12B/CTNNB1/SNAI1/PTPRM/CDC42/WASF3/RAP1B/MAPK1/FER/YES1/ACTN1/FGFR1/NECTIN3/SMAD4/ACP1/MYL12A/VCL/FYN/CSNK2A2/WASF1/CSNK2B/MAP3K7/TCF7/ERBB2/RAP1A/WASL/SMURF2/PARD3/RADIL/NECTIN2	1.41107727481297
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/2614	30/9376	1.43473603672533	ABCC5/ABCC3/IL6/NFKB1/ATIC/GGH/GART/SHMT2/ABCC4/CHUK/SLC19A1/TNF	1.48277149133818
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	112/2614	362/9376	1.10974058089252	MYC/LAMA2/LAMB1/PDGFRA/FGF2/COL4A1/GNG4/COL1A2/PTEN/AKT1/CCND2/CSF1/VEGFC/EIF4E/CDKN1B/SOS2/PIK3CA/COL4A5/ITGAV/THBS2/MCL1/COL6A1/PRKCA/COL6A2/KITLG/ATF2/ITGB5/CSF3/IL6/FGF7/RHEB/NFKB1/GNB2/VEGFB/PKN2/MAPK1/BCL2/PPP2CB/COL4A4/CREB5/STK11/MAP2K2/PRKAA1/TLR4/COL4A2/OSMR/PDGFRB/EFNA4/FGFR1/YWHAQ/CDK4/DDIT4/PTK2/RAF1/LAMA1/HSP90AB1/ATF6B/GSK3B/MDM2/NRAS/YWHAG/CRTC2/NR4A1/ITGA6/GNG5/MAP2K1/COL4A3/PPP2R3A/RBL2/KRAS/EFNA5/PIK3R3/GNG12/AKT3/ERBB2/TSC1/EPHA2/EPOR/PPP2R5C/CASP9/TP53/CHUK/HSP90AA1/PPP2R2A/COL4A6/CREB3L4/ANGPT1/COL1A1/THBS3/PPP2R5A/EIF4B/PDPK1/IFNAR2/LPAR6/PPP2CA/IRS1/GHR/HGF/TNC/THBS1/PHLPP2/PPP2R3B/LAMC1/ITGA5/PPP2R5B/PDGFC/NGF/GNG10/COMP/CDK2/PSPN/THBS4	1.32392569078149
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	44/2614	133/9376	1.18662378977283	COMT/GNG4/AKT1/PPP1CB/PPP1CC/MAPK10/GNAI3/PRKCA/ATF2/CAMK2D/GNAI1/GNB2/PPP3CC/MAPK8/PPP2CB/PLCB3/CREB5/GRIA4/ATF6B/GSK3B/PPP3CB/MAPK9/GNG5/PPP2R3A/CACNA1C/CACNA1D/GNAL/GNG12/AKT3/PPP2R5C/PPP2R2A/CALM2/ITPR3/CREB3L4/PPP2R5A/PPP2CA/KIF5A/MAPK12/MAPK14/PPP2R3B/LRTOMT/PPP2R5B/MAOB/GNG10	1.34768127735849
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	37/2614	110/9376	1.20648257633721	IFNGR1/IFNGR2/AKT1/LDHB/EIF4E/CUL2/CDKN1B/PIK3CA/SERPINE1/PRKCA/PFKM/ELOC/CAMK2D/IL6/HIF1A/NFKB1/MAPK1/BCL2/MAP2K2/TLR4/PDHB/MKNK2/MAP2K1/STAT3/EGLN1/PIK3R3/PDHA1/AKT3/LDHA/ERBB2/ARNT/TIMP1/VHL/ANGPT1/RBX1/PDK1/PFKFB3	1.35436103815187
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	24/2614	68/9376	1.26594356181646	MYC/AKT1/PIM1/SOS2/PIK3CA/RUNX1T1/NFKB1/MAPK1/RARA/MAP2K2/RAF1/NRAS/MAP2K1/KRAS/STAT3/TCF7/RUNX1/PIK3R3/AKT3/BRAF/CHUK/PPARD/PER2/STAT5B	1.36841112622971
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	18/2614	49/9376	1.31761472760489	C1GALT1C1/POGLUT1/C1GALT1C1L/GXYLT2/POFUT2/OGT/C1GALT1/GXYLT1/GALNT7/B4GALT3/GALNT13/POFUT1/B4GALT1/FUT10/GALNT12/XXYLT1/GALNT18/B3GLCT	1.38588926395155
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	51/2614	157/9376	1.16515187695846	MYC/SNAI2/WNT2/ACTG1/BMP2/ID2/CCND2/PPP1CB/SMAD7/PPP1CC/CTNNB1/YAP1/MOB1A/FRMD6/FZD2/SERPINE1/TP53BP2/TEAD3/WTIP/ID1/SAV1/STK3/PPP2CB/TEAD2/FZD1/YWHAQ/SMAD4/FZD8/GSK3B/YWHAG/WNT6/TCF7/GDF7/DVL3/BMPR1A/BTRC/BBC3/DVL2/PPP2R2A/MOB1B/RASSF1/WWTR1/DLG4/AJUBA/PPP2CA/PARD3/LLGL1/DLG2/FZD10/TGFB3/PARD6G	1.29745492570868
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	22/2614	62/9376	1.27274970999827	ADAM17/MAML2/KAT2A/TLE4/HDAC1/DTX1/APH1B/NUMB/NCSTN/DTX3L/JAG1/DTX3/DVL3/KAT2B/PSENEN/ATXN1/MAML1/DLL1/DVL2/PSEN1/ATXN1L/DTX2	1.33965469989216
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	54/2614	168/9376	1.15291288665428	FAS/IFNGR1/IFNGR2/TNFRSF1A/PPID/GLUD1/MAPK10/SLC25A5/CHMP5/CYLD/TNFAIP3/CAMK2D/STAT2/CAPN2/CASP8/MAPK8/VDAC3/BCL2/BID/VDAC2/TLR4/MLKL/CHMP7/HSP90AB1/STAT1/CASP1/TRPM7/PYGL/VDAC1/MAPK9/IL1A/BAX/PPIA/FADD/STAT3/AIFM1/CHMP1B/PGAM5/TICAM1/TNFRSF10B/CHMP2B/DNM1L/HSP90AA1/TRAF2/EIF2AK2/SPATA2L/IFNAR2/PLA2G4A/TRAF5/PLA2G4C/STAT5B/GLUD2/USP21/TNF	1.24341733872598
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	12/2614	31/9376	1.38845422908902	DERA/RPE/RPIA/PFKM/PGM2/TKT/PRPS2/PGM1/TALDO1/PRPS1/RGN/PGLS	1.34688927467102
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	50/2614	155/9376	1.15704519090752	SEC22B/ACTG1/SEC61B/HLA-F/TAP1/CALR/M6PR/TUBA3D/TAP2/ITGAV/THBS2/STX12/COLEC11/ATP6V1G1/SEC61G/ITGB5/LAMP2/DYNC2H1/ATP6V0E1/TLR4/STX18/VAMP3/ATP6V1C1/PIK3C3/TUBB2A/CANX/PIKFYVE/HLA-B/C3/STX7/RAB7A/HLA-DOB/LAMP1/ATP6V1H/TUBA1A/TUBB6/ATP6V1E2/TUBB2B/THBS3/ATP6V1D/ATP6V1A/ATP6V1C2/THBS1/PLA2R1/ATP6V0A2/ITGA5/C1R/ATP6V0E2/COMP/THBS4	1.22575119834495
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	8/2614	19/9376	1.51024845971087	GCSH/DLD/DLST/PDHB/DLAT/LIPT1/PDHA1/BCKDHB	1.38417510733213
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	9/2614	22/9376	1.46734367392363	ALDH2/HNMT/CARNMT1/CNDP2/ALDH3A2/ALDH9A1/ASPA/MAOB/ALDH1B1	1.36442564188621
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	40/2614	122/9376	1.17601314485682	AKT1/PIK3CA/PFKM/CAB39/SREBF1/SIRT1/RHEB/RAB10/PPP2CB/HMGCR/CREB5/STK11/PRKAA1/ELAVL1/PRKAB2/ADIPOR1/TBC1D1/RAB8A/CRTC2/PPP2R3A/MAP3K7/PIK3R3/ACACB/AKT3/ACACA/TSC1/PPP2R5C/PPP2R2A/CREB3L4/PPP2R5A/PDPK1/PPP2CA/STRADB/IRS1/PFKFB3/STRADA/PRKAB1/PPP2R3B/PPP2R5B/PPARG	1.21663727179293
Organismal Systems	Nervous system	hsa04730	Long-term depression	21/2614	60/9376	1.25539403213466	GNAI3/PRKCA/GNAI1/MAPK1/PRKG1/PPP2CB/PLCB3/MAP2K2/RAF1/GNA12/NRAS/MAP2K1/KRAS/BRAF/ITPR3/PPP2CA/PLA2G4A/GNA13/PLA2G4C/GUCY1B1/GUCY1A2	1.23387872672025
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	25/2614	73/9376	1.22836989445661	TRIM5/CPSF6/RAN/NUP153/FEZ1/KAT2A/CCNT2/PDCD6IP/CPSF7/TSG101/MX1/CDK9/XPO1/PPIA/ELL2/APOBEC3B/SMARCB1/MLLT3/ELL/KAT2B/APOBEC3G/MX2/BICD1/MDFIC/APOBEC3F	1.21783826981618
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	34/2614	103/9376	1.18400546720051	LAMA2/LAMB1/COL3A1/COL4A1/COL1A2/CXCL1/CASP3/PIK3CA/CXCL8/COL4A5/PRKCA/IL6/NFKB1/PLCB3/COL4A4/PRDX1/TLR4/COL4A2/ACTN1/PTK2/LAMA1/VCL/COL4A3/IL1R1/RAB7A/PIK3R3/GNAL/CXCL2/COL4A6/COL1A1/CD1D/LAMC1/TGFB3/TNF	1.16745474888395
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	16/2614	45/9376	1.27532092153362	ABCA8/TAP1/ABCC5/ABCA6/TAP2/ABCC3/ABCD4/ABCA5/ABCA1/ABCD3/ABCA9/ABCB5/ABCC4/ABCB10/ABCC9/ABCA10	1.15101828617987
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/2614	23/9376	1.40354612288347	PCNA/PMS2/MLH1/MSH6/RPA3/MLH3/RFC4/SSBP1/RFC5	1.20470989249689
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/2614	20/9376	1.43473603672533	UAP1/TGDS/UGP2/CMAS/NANP/GNE/CYB5R2/GMDS	1.21003067387627
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/2614	14/9376	1.53721718220571	FUT8/B4GALT3/CHST2/B4GALT1/CHST1/B4GALT4	1.25063460271201
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	49/2614	155/9376	1.13390428708937	WNT2/FH/RASD1/CTNNB1/FZD2/GNAI3/CDKN1B/ADCY3/PBX1/ATF2/CAMK2D/GNAI1/RAP1B/MAPK1/PLCB3/CREB5/MAP2K2/FZD1/CDK4/FZD8/ATF6B/GSK3B/NR4A1/CACNA1H/MAP2K1/CACNA1C/CACNA1G/WNT6/CACNA1D/TCF7/PDE8B/DVL3/RB1/PDE8A/BRAF/ARNT/CDKN2B/RAP1A/WDR5/DVL2/ITPR3/CREB3L4/AGTR1/E2F3/FZD10/ADCY6/CDK2/WDR5B/POMC	1.04513445725298
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	21/2614	62/9376	1.2148974504529	SOD2/HSPA1B/HSPA1A/HSPA8/CAT/AKT1/ATG5/PIK3CA/ADCY3/SIRT1/HDAC1/PRKAA1/PRKAB2/NRAS/KRAS/PIK3R3/AKT3/IRS1/PRKAB1/HSPA1L/ADCY6	1.05550388851335
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/2614	69/9376	1.19561336393777	AKT1/MAPK10/SOS2/PIK3CA/PRKCA/MAP2K3/MAPK1/MAPK8/MAP2K2/RAF1/NRAS/MAPK9/MAP2K1/FYN/KRAS/PIK3R3/AKT3/PDPK1/PLA2G4A/PLA2G4C/MAPK12/MAPK14/TNF	1.01395587673905
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	29/2614	89/9376	1.16874564789423	LAMA2/LAMB1/COL4A1/SDC4/COL1A2/CD47/COL4A5/ITGAV/THBS2/COL6A1/CD44/COL6A2/ITGB5/COL4A4/COL4A2/LAMA1/ITGA6/COL4A3/COL4A6/COL1A1/THBS3/FREM1/TNC/NPNT/THBS1/LAMC1/ITGA5/COMP/THBS4	0.994467759553756
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	10/2614	27/9376	1.32845929326419	SCP2/ELOVL5/HSD17B4/ELOVL6/HACD1/HACD3/ELOVL4/ACOX1/ACOT2/ELOVL3	1.06262909519333
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	35/2614	110/9376	1.1412673019406	AKT1/CDC26/MAPK10/GNAI3/PIK3CA/ADCY3/GNAI1/MAPK1/MAPK8/ANAPC7/ANAPC10/CDC27/RAF1/HSP90AB1/ANAPC13/MAPK9/MAP2K1/PGR/CDC23/KRAS/CDC16/CDC25B/PIK3R3/AKT3/BRAF/CPEB2/ANAPC4/HSP90AA1/CPEB1/MAPK12/MAPK14/CCNB1/ADCY6/MAD2L1/CDK2	0.926600845006553
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	13/2614	37/9376	1.26024111333981	GLS/NIT2/GLUD1/PPAT/GFPT2/GOT1/GFPT1/ALDH5A1/ASPA/ADSL/RIMKLB/GLUD2/CPS1	0.986114691608598
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	16/2614	47/9376	1.22105194614921	SOCS2/SOCS3/SOCS1/MAPK10/PIK3CA/MAPK1/MAPK8/MAPK9/PRKCD/CACNA1C/CACNA1G/CACNA1D/PIK3R3/SOCS4/IRS1/TNF	0.944553522229562
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	43/2614	138/9376	1.11763857933313	AR/CDC26/PPP1CB/SKP1/PPP1CC/ADCY3/CAMK2D/PPP3CC/MAPK1/ANAPC7/PPP2CB/ANAPC10/PPP3R1/CDC27/YWHAQ/ANAPC13/PPP3CB/YWHAG/MAP2K1/PGR/CDC23/CDC16/CUL1/CPEB2/ANAPC4/BTRC/PPP2R5C/ESPL1/CALM2/CPEB1/ITPR3/PPP2R5A/RBX1/PPP2CA/MAPK12/MAPK14/CCNB1/FBXO5/PPP2R5B/ADCY6/MAD2L1/CDK2/STAG3	0.865567979528084
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	11/2614	31/9376	1.27274970999827	CSAD/ALDH2/HIBCH/AOC3/CNDP2/ALDH3A2/ALDH9A1/ECHS1/ACOX1/ALDH6A1/ALDH1B1	0.945706421906693
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	51/2614	166/9376	1.10198099206313	AKT1/PPP1CB/PPP1CC/SLC25A5/GNAI3/ADCY3/BDKRB2/RGS2/ATP2A2/ATF2/ADRA2C/GNAI1/SLC8A1/PPP3CC/MAPK1/VDAC3/PRKG1/VDAC2/NFATC1/PLCB3/CREB5/NPR1/MAP2K2/PPIF/PPP3R1/RAF1/ATF6B/GNA12/PPP3CB/ATP1A1/VDAC1/MAP2K1/CACNA1C/CACNA1D/AKT3/GTF2I/CALM2/ITPR3/CREB3L4/PDE5A/EDNRB/ADRA2A/AGTR1/IRS1/TRPC6/KCNJ8/GNA13/GUCY1B1/GUCY1A2/ADCY6/PDE3A	0.824222200227012
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	46/2614	149/9376	1.10734660552626	AVPR1A/PDGFRA/AKT1/SOS2/PIK3CA/CXCL8/ADCY3/PRKCA/KITLG/DNM1/ARF1/RHEB/MAPK1/SHC3/PLCB3/MAP2K2/RALB/PDGFRB/ARF6/RAF1/GNA12/NRAS/MAP2K1/FYN/KRAS/PIK3R3/AKT3/PIP5K1A/TSC1/CYTH2/PLD1/AGPAT5/LPAR6/RRAS/GRM7/AGTR1/RALA/PLA2G4A/GNA13/SPHK1/PTPN11/PLA2G4C/SHC2/GAB1/PDGFC/ADCY6	0.821205853632406
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	14/2614	41/9376	1.22477466549723	GCSH/AOC3/DLD/ALAS1/SHMT2/PGAM1/PSPH/BPGM/GCAT/SRR/SARDH/CHDH/MAOB/BHMT	0.896773928776485
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	14/2614	41/9376	1.22477466549723	RAD50/NBN/ATM/RPA3/RAD51B/UIMC1/ABRAXAS1/RAD51C/RAD52/PALB2/TOP3A/RAD54B/SSBP1/BABAM2	0.896773928776485
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	43/2614	139/9376	1.10959801401419	HSPA1B/HSPA1A/HSPA8/AKT1/GNAI3/KRT10/SOS2/PIK3CA/ADCY3/MMP2/FKBP4/GABBR1/ATF2/GNAI1/MAPK1/SHC3/RARA/BCL2/PLCB3/CREB5/MAP2K2/RAF1/KRT23/HSP90AB1/ATF6B/NRAS/PRKCD/MAP2K1/PGR/ESR1/KRAS/PIK3R3/AKT3/NCOA1/HSP90AA1/CALM2/ITPR3/CREB3L4/KRT34/HSPA1L/SHC2/ADCY6/POMC	0.809366937289117
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/2614	109/9376	1.11883085432709	MAP3K8/TBK1/NFKBIA/AKT1/MAPK10/IRF7/PIK3CA/CXCL8/MAP2K3/STAT2/IL6/CTSK/NFKB1/CASP8/MYD88/MAPK1/MAPK8/MAP2K2/TLR4/STAT1/IRAK4/MAPK9/MAP2K1/FADD/MAP3K7/PIK3R3/TICAM1/TRAF6/AKT3/CHUK/IFNAR2/MAPK12/MAPK14/TNF	0.77584279893139
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	26/2614	82/9376	1.13729076081886	MGST1/MGST3/NME7/CMPK1/DUT/NAT1/TPMT/GSTO1/GMPS/HPRT1/ITPA/CYP2A7/GSTM3/NME3/UCKL1/NME1/RRM2B/GSTA4/CES1/GSTM2/GSTT2B/IMPDH2/CDADC1/UCK2/GSTM5/UCK1	0.776332469318894
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	28/2614	89/9376	1.12844407382891	PDGFRA/TUBA3D/GNAI3/SOS2/ADCY3/PRKCA/HTR2B/GNAI1/MAPK1/PRKG1/PLCB3/MAP2K2/PDGFRB/TUBB2A/RAF1/NRAS/MAP2K1/KRAS/MAPK7/TUBA1A/TUBB6/TUBB2B/ITPR3/GUCY1B1/GUCY1A2/GJA1/PDGFC/ADCY6	0.756958724106815
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	32/2614	103/9376	1.11435808677695	COL3A1/COL4A1/COL21A1/MME/COL1A2/COL5A2/COL15A1/COL4A5/COL6A1/CPB1/SLC36A4/SLC38A2/SLC3A2/COL6A2/SLC8A1/COL4A4/COL4A2/COL27A1/ACE2/ATP1A1/COL4A3/ELN/COL24A1/COL18A1/COL16A1/COL4A6/COL12A1/KCNE3/COL1A1/COL5A3/SLC9A3/COL28A1	0.725564808004056
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	26/2614	83/9376	1.12358846249574	TBK1/NFKBIA/CASP3/CGAS/IRF7/CASP7/G3BP1/POLR1C/IL6/POLR2H/IFI16/NFKB1/CASP8/POLR2K/MLKL/POLR3K/POLR1D/CASP1/POLR3F/FADD/GSDME/POLR3H/CHUK/POLR3B/POLR2F/POLR3G	0.703136841264142
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	43/2614	142/9376	1.08615580245051	IFNGR1/JUNB/IFNGR2/SOCS3/FOSL1/NFKBIA/TNFRSF1A/AKT1/SOCS1/CSF1/JUND/MAPK10/PIK3CA/ATP2A2/CYLD/STAT2/CTSK/NFKB1/PPP3CC/MAPK1/MAPK8/NFATC1/PPP3R1/STAT1/PPP3CB/MAPK9/IL1A/MAP2K1/FYN/IL1R1/MAP3K7/PIK3R3/TRAF6/AKT3/CHUK/RELB/TRAF2/ITPR3/IFNAR2/MAPK12/MAPK14/PPARG/TNF	0.643183086548049
NA	NA	hsa04517	IgSF CAM signaling	88/2614	299/9376	1.0556586223397	ACTG1/UNC5C/NRP1/MYL12B/ARPC1A/AKT1/DYNLL1/PAK3/CTNNB1/ARPC3/MAPK10/TUBA3D/PIK3CA/PRKCA/CDC42/PMP22/CNTNAP1/ABL1/TRIO/ROBO1/JAM3/NCK1/LRFN5/ACTR3/RAP1B/MAPK1/MAPK8/KIRREL1/MAP2K2/NLGN1/ACTN1/NCK2/FGFR1/NECTIN3/PTK2/ARF6/TUBB2A/CNTN1/GSK3B/ARPC5L/CASK/MYL12A/MAPK9/VCL/MAP2K1/FYN/SRGAP1/PIK3R3/FGG/TRAF6/AKT3/BCAR1/UNC5B/RAP1A/WASL/SLIT3/FGB/TUBA1A/MPDZ/TUBB6/TUBB2B/NTN1/PDPK1/PARD3/PLXNA1/TRPC6/ACTR2/PTPN11/ROBO2/ANK2/MAPK12/ARPC1B/MAPK14/DOK1/SLITRK4/PLXNA2/PPFIA2/ARPC4/ITGA5/CDH2/ACTR3C/NCAM2/PARD6G/ACTR3B/NECTIN2/NRP2/ERC1/CXADR	0.608131816394493
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	11/2614	33/9376	1.19561336393777	IDH3A/DLD/BCAT1/ACO1/AADAT/DLST/PDHB/DLAT/GOT1/PDHA1/BCKDHB	0.699863209026817
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/2614	50/9376	1.14778882938026	VCAM1/CXCL8/THBS2/SDC2/CSF3/IL6/MYD88/TLR4/LRP1/THBS3/HGF/THBS1/TGFB3/COMP/THBS4/TNF	0.651447995896458
Organismal Systems	Immune system	hsa04611	Platelet activation	38/2614	126/9376	1.08174542451513	COL3A1/ACTG1/MYL12B/COL1A2/AKT1/PPP1CB/PPP1CC/GNAI3/PIK3CA/ADCY3/GNAI1/P2RY1/RAP1B/MAPK1/PRKG1/PLCB3/MYL12A/FYN/ARHGEF1/STIM1/PIK3R3/FGG/AKT3/RAP1A/FGB/ITPR3/SNAP23/COL1A1/ARHGEF12/PLA2G4A/GNA13/PLA2G4C/MAPK12/MAPK14/GUCY1B1/GUCY1A2/ADCY6/ADAMTS13	0.574352751996382
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	50/2614	168/9376	1.0675119320873	MYC/IL15RA/IFNGR1/PDGFRA/SOCS2/IFNGR2/SOCS3/AKT1/IL15/CCND2/SOCS1/AOX1/PIM1/STAM/SOS2/PIK3CA/MCL1/STAM2/IL13RA2/STAT2/CSF3/IL6/CLCF1/BCL2/OSMR/PDGFRB/RAF1/STAT1/PIAS2/STAT3/PIK3R3/AKT3/EPOR/LIF/SOCS6/CTF1/TSLP/SOCS4/IFNAR2/IL11RA/IL13RA1/GHR/PTPN11/PIAS3/STAT5B/IL23A/IL6ST/IL10RB/IL11/IL19	0.548976013499938
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	6/2614	17/9376	1.26594356181646	CSAD/GGT5/CDO1/ADO/GGT7/FMO4	0.682338795761834
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	25/2614	82/9376	1.09354880847967	HSPA1B/HSPA5/HSPA1A/HSPA8/NFYB/HLA-F/TAP1/CALR/B2M/HSPA4/TAP2/PDIA3/HSP90AB1/CANX/HLA-B/PSME2/HLA-DOB/RFX5/HSP90AA1/NFYA/KLRC2/HSPA1L/RFXAP/KLRC1/TNF	0.528986634320459
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	20/2614	65/9376	1.10364310517333	TRPC4/AKT1/PIK3CA/GABBR1/PRKCA/TRPC1/MAPK1/PLCB3/MAP2K2/RAF1/NRAS/CACNA1H/MAP2K1/CACNA1C/CACNA1G/KRAS/CACNA1D/PIK3R3/AKT3/ITPR3	0.521314467578771
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/2614	24/9376	1.19561336393777	EXT1/B4GALT7/EXTL2/B3GALT6/XYLT2/NDST2/HS2ST1/HS6ST2	0.596558090591684
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	69/2614	238/9376	1.0398822114921	PDGFRA/FGF2/TBK1/GNG4/AKT1/PAK3/CSF1/VEGFC/MAPK10/SOS2/PIK3CA/PLA2G2A/PRKCA/CDC42/KITLG/SYNGAP1/ABL1/FGF7/NFKB1/GNB2/VEGFB/RAP1B/MAPK1/SHC3/MAPK8/RASA3/MAP2K2/RALB/PDGFRB/EFNA4/FGFR1/ARF6/RAF1/EXOC2/NRAS/MAPK9/GNG5/MAP2K1/RALGAPA1/KRAS/RASAL2/ELK1/RASA2/EFNA5/PIK3R3/GNG12/AKT3/EPHA2/PLD1/RAP1A/CHUK/CALM2/NF1/RASSF1/ANGPT1/RALGAPB/RRAS/RALA/HGF/PLA2G4A/PTPN11/PLA2G4C/BRAP/SHC2/GAB1/PDGFC/NGF/GNG10/ETS2	0.387474369690277
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/2614	28/9376	1.15291288665428	ATP6V1G1/ATP6V0E1/ATP6V1C1/ATP6V1E2/ATP6V1D/ATP6V1A/ATP6V1C2/ATP6V0A2/ATP6V0E2	0.503807463945631
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/2614	18/9376	1.19561336393777	HEXA/MANBA/NEU1/GLB1/ENGASE/MAN2B1	0.516468811371178
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	21/2614	70/9376	1.07605202754399	LAMA2/ACTG1/HLA-F/CASP3/SGCB/ABL1/CYCS/SSPN/CASP8/BID/EIF4G2/LAMA1/SNTB2/SNTB1/FYN/CD55/HLA-B/HLA-DOB/CASP9/SGCE/CXADR	0.39708102962929
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	26/2614	88/9376	1.05974820894484	PLAU/F3/BDKRB1/PROCR/CFD/SERPINE1/CFI/BDKRB2/CD46/PLAT/PLAUR/CFH/CD55/C3/C1S/C4B/FGG/MASP1/PROS1/FGB/CFHR3/SERPIND1/C7/C1R/F5/SERPINF2	0.350111172923394
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	20/2614	67/9376	1.07069853486965	MINPP1/ADH5/LDHB/ALDH2/DLD/ADH1B/PFKM/ALDH3A2/ADPGK/PGM2/PDHB/DLAT/ALDH9A1/PGAM1/PGM1/PDHA1/LDHA/ADH1C/BPGM/ALDH1B1	0.361074772708293
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/2614	67/9376	1.07069853486965	PPP1CB/PPP1CC/PRKCA/CAMK2D/RAP1B/PPP3CC/MAPK1/PLCB3/MAP2K2/PPP3R1/RAF1/NRAS/PPP3CB/MAP2K1/CACNA1C/KRAS/BRAF/RAP1A/CALM2/ITPR3	0.361074772708293
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	58/2614	201/9376	1.03500858370732	MYC/CEBPB/PLAU/GADD45A/HOXA10/ID2/CCND2/DDX5/HOXA11/NFKBIZ/CDKN1B/MEIS1/CXCL8/PRCC/PBX1/RUNX1T1/CCNT2/IL6/HDAC1/NFKB1/PLAT/RARA/ATM/FUT8/MLF1/SUPT3H/ELK4/CDK14/SS18L1/PTK2/CDK9/EWSR1/MDM2/BAX/DDIT3/BCL6/MLLT3/POLK/MAX/ZBTB17/DOT1L/GADD45B/RUNX1/SS18/ETV6/HOXA9/GADD45G/KLF3/TP53/PBX3/ETV7/BMI1/PER2/TRAF1/TCF3/BAK1/PAX8/PPARG	0.311939506206697
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/2614	15/9376	1.19561336393777	SLC33A1/HEXA/ST6GALNAC4/GLB1/ST6GALNAC5	0.471393809756198
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/2614	15/9376	1.19561336393777	NTPCR/NFS1/ACP1/THTPA/TPK1	0.471393809756198
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	31/2614	107/9376	1.03917797052535	PPP4C/AKT1/LDHB/PFKM/ATF2/CAMK2D/SIRT1/PPP3CC/PRMT1/PLCB3/CREB5/PRKAA1/PDHB/PPP3R1/PHKG1/PPP4R3B/PYGL/PRKAB2/PPP3CB/CRTC2/PGAM1/PDHA1/ACACB/AKT3/LDHA/ACACA/CALM2/ITPR3/CREB3L4/PHKA2/PRKAB1	0.253406779482803
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/2614	12/9376	1.19561336393777	COQ2/NQO1/COQ5/COQ6	0.421559896067514
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	25/2614	86/9376	1.04268607320154	LAMA2/CACNA2D1/ACTG1/CTNNB1/ITGAV/SGCB/ATP2A2/CACNB2/ITGB5/SSPN/SLC8A1/LAMA1/SNTB2/CACNA2D3/SNTB1/ITGA6/CACNA1C/CACNA1D/TCF7/SGCE/CACNB4/ITGA5/GJA1/CDH2/LMNA	0.24724551371455
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/2614	115/9376	1.02926715678121	JUND/GNAI3/ADCY3/PRKCA/ATF2/MMP16/GNAI1/ARHGEF11/MAPK1/STK39/BCL2/PLCB3/CREB5/PDE4B/FGFR1/RAF1/ATF6B/GNA12/WNK2/MAP2K1/ARHGEF1/CYP27B1/NACA/BRAF/LRP6/PLD1/ITPR3/CREB3L4/PTH1R/GNA13/EGR1/ADCY6/MMP14	0.196336641937929
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/2614	44/9376	1.05974820894484	PARG/PCNA/MPG/POLG2/PARP4/LIG3/PARP2/FEN1/RFC4/POLE2/PARP3/MUTYH/RFC5	0.246981663198575
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	40/2614	140/9376	1.0248114548038	GNG4/AKT1/GNAI3/SERPINE1/ADCY3/GNAI1/GNB2/SLC8A1/MAPK1/PLAT/TFAM/PLCB3/MAP2K2/PRKAA1/SMAD4/PIK3C3/MAP1LC3B/RAF1/PRKAB2/NRAS/GNG5/MAP2K1/JAG1/PIK3R4/KRAS/GNG12/AKT3/BECN1/CALM2/ITPR3/ACTA2/RRAS/AGTR1/GNA13/SPHK1/PRKAB1/EGR1/ADCY6/GNG10/KLF2	0.183897206418141
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	11/2614	37/9376	1.06635786513369	COMT/ADH5/AOX1/AOC3/ADH1B/GOT1/FAHD1/ADH1C/LRTOMT/FAH/MAOB	0.251445533998569
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	29/2614	101/9376	1.02988477883749	WNT2/CTNNB1/FZD2/GNAI3/ADCY3/PRKCA/KITLG/CAMK2D/GNAI1/MAPK1/PLCB3/MAP2K2/FZD1/RAF1/FZD8/GSK3B/NRAS/MAP2K1/WNT6/KRAS/TCF7/DVL3/DVL2/CALM2/CREB3L4/EDNRB/FZD10/ADCY6/POMC	0.187739051999514
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/2614	23/9376	1.09164698446492	MME/ENPEP/ATP6AP2/PREP/ACE2/THOP1/AGTR1	0.273594572073937
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/2614	27/9376	1.06276743461135	HMGCS1/HADH/ECHS1/AACS/ACAT2/ALDH5A1/ACAT1/OXCT1	0.203064743840327
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	27/2614	95/9376	1.01941771030484	IL15/CSF1/CXCL1/CXCL8/CXCL12/ATP6V1G1/IL6/CTSK/ATP6V0E1/TLR4/ATP6V1C1/CXCL5/IL1A/HLA-DOB/ATP6V1H/CXCL2/ATP6V1E2/ANGPT1/ATP6V1D/ATP6V1A/IL23A/ATP6V1C2/ATP6V0A2/ATP6V0E2/TGFB3/IL11/TNF	0.118266918285333
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	42/2614	149/9376	1.01105559635006	NDUFB5/NDUFB3/GNG4/NDUFC2/GABRE/NDUFV2/MAPK10/NDUFA4/GNAI3/ADCY3/NDUFA9/NDUFB8/PRKCA/NAPEPLD/NDUFAB1/NDUFB6/GNAI1/NDUFA8/GNB2/MAPK1/MAPK8/PLCB3/NDUFS4/NDUFA7/GRIA4/NDUFS3/GABRA2/MAPK9/GNG5/CACNA1C/CACNA1D/ABHD6/GNG12/NDUFA10/NDUFB4/NDUFA5/ITPR3/NDUFA12/MAPK12/MAPK14/ADCY6/GNG10	0.0845757571332488
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	28/2614	99/9376	1.0144598239472	LAMA2/CACNA2D1/ACTG1/ITGAV/SGCB/ATP2A2/CACNB2/ITGB5/IL6/SSPN/SLC8A1/PRKAA1/LAMA1/SNTB2/PRKAB2/CACNA2D3/SNTB1/ITGA6/CACNA1C/CACNA1D/TPM4/SGCE/CACNB4/PRKAB1/ITGA5/TGFB3/TNF/LMNA	0.0899244252942061
Genetic Information Processing	Transcription	hsa03040	Spliceosome	68/2614	243/9376	1.00372479935517	HSPA1B/SRSF9/DDX39B/EIF4A3/HSPA1A/SNRPA1/HSPA8/LSM6/SRSF1/LSM8/SRSF7/SNRNP40/DDX5/SF3B6/TRA2A/PPIL1/PHF5A/SRSF6/LSM5/SRSF10/PLRG1/HNRNPA3/THOC1/SRSF2/MAGOHB/SNRPF/MAGOH/BCAS2/THOC6/SF3B1/LSM2/ALYREF/PRPF38A/NCBP1/HNRNPA1/THOC7/SNRPE/SRSF8/PPIH/SF3A3/SMNDC1/PRPF31/THOC3/SF3B4/RBMXL1/AQR/SNRPB2/CHERP/USP39/DHX15/U2AF1L4/SNRPB/BUD31/SNRPC/THOC5/LSM4/SF3B5/RBM17/SRSF5/SNRPD1/BUD13/SF1/NCBP2/HNRNPU/HSPA1L/SRSF4/CWC15/HNRNPC	0.0365763309259756
NA	NA	hsa04981	Folate transport and metabolism	9/2614	31/9376	1.04134067181677	MTHFS/ABCC5/ABCC3/SHMT2/ABCC4/BHMT2/MTHFD1/BHMT/SLC19A1	0.143340716378039
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	43/2614	154/9376	1.00152028537644	CACNA2D1/ACTG1/PPP1CB/PPP1CC/GNAI3/ADCY3/RGS2/PRKCA/CACNB2/CAMK2D/GNAI1/PPP1R12B/PPP3CC/MAPK1/NFATC1/PLCB3/NPR1/MAP2K2/PRKAA1/PPP3R1/RAF1/PRKAB2/NRAS/PPP3CB/CACNA2D3/MAP2K1/CACNA1C/KRAS/CACNA1D/ELK1/CAMK1/MAPK7/CALM2/ITPR3/CACNB4/PLA2G4A/PLA2G4C/GUCY1B1/PRKAB1/GUCY1A2/CD38/ADCY6/OXTR	0.0118269773788572
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	8/2614	28/9376	1.0248114548038	B4GALT3/FUT4/B4GALT1/A4GALT/B3GALT1/B4GALT4/ST3GAL4/B3GALT5	0.0817471724915355
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2614	10/9376	1.07605202754399	PAPSS1/SQOR/SELENBP1	0.149601024162535
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	18/2614	65/9376	0.993278794655994	ADCY3/PBX1/ATF2/PLCB3/CREB5/ATF6B/NR4A1/CACNA1H/CACNA1C/CACNA1G/CACNA1D/PDE8B/PDE8A/ITPR3/CREB3L4/AGTR1/ADCY6/POMC	-0.0338069915942623
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/2614	36/9376	0.996344469948142	C1GALT1C1/C1GALT1C1L/C1GALT1/ST6GALNAC4/GALNT7/GALNT13/GCNT4/GALNT12/GALNT18/ST6GALNAC2	-0.0136624635854786
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/2614	36/9376	0.996344469948142	PCNA/PRIM2/RNASEH1/RPA3/PRIM1/FEN1/RFC4/SSBP1/POLE2/RFC5	-0.0136624635854786
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	30/2614	109/9376	0.98720369499449	IFNGR1/IFNGR2/NFKBIA/NFKBIE/MAPK10/IL6/HIF1A/NFKB1/PPP3CC/MAPK1/MAPK8/RARA/NFATC1/PPP3R1/SMAD4/HSP90AB1/STAT1/PPP3CB/MAPK9/IL1R1/STAT3/HLA-DOB/RUNX1/CHUK/HSP90AA1/MAPK12/STAT5B/MAPK14/IL23A/IL6ST	-0.083546660904479
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	19/2614	69/9376	0.987680604992072	PPP1CB/PPP1CC/PRKCA/ATF2/CAMK2D/SIRT1/HDAC1/PPP3CC/CREB5/GRIA4/PPP3R1/ATF6B/PPP3CB/CACNA1C/CACNA1D/CALM2/CREB3L4/ARC/MAOB	-0.0638572064541172
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	64/2614	233/9376	0.985226462987348	LAMA2/COL3A1/FBLN2/VIM/SYNPO2/ACTG1/COL4A1/CSRP1/SDC4/COL1A2/COL5A2/DCN/CAPZA2/COL4A5/VCAN/ITGAV/THBS2/SGCB/COL6A1/SDC2/COL6A2/TMEM43/TMOD2/ITGB5/SSPN/SYNE1/COL4A4/COL4A2/COL27A1/LAMA1/SUN1/SNTB2/ATP1A1/SNTB1/ITGA6/VCL/COL4A3/CAPZA1/AMPD2/CAPZB/ELN/TPM4/FHL3/COL24A1/PDLIM1/COL4A6/SGCE/PDLIM7/LBR/COL1A1/THBS3/LMNB2/DAAM1/COL5A3/ANK2/THBS1/ANKRD23/TMOD1/ITGA5/AMPD3/COMP/FMNL2/THBS4/LMNA	-0.14197730618226
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/2614	78/9376	0.965687717026661	MARCKSL1/IFNGR1/IFNGR2/NFKBIA/NFKB1/MYD88/MAPK1/TLR4/STAT1/IRAK4/IL1A/C3/ELK1/MAP3K7/HLA-DOB/EEF1A1/TRAF6/MAPK12/MAPK14/TGFB3/TNF	-0.189192097418421
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	26/2614	97/9376	0.961421055537589	RASD1/GNG4/GNAI3/ADCY3/PRKCA/CAMK2D/GNAI1/GNB2/MAPK1/PRKG1/PLCB3/GRIA4/CACNA1H/PER1/GNG5/CACNA1C/CACNA1G/CACNA1D/GNG12/CALM2/ITPR3/PER2/GUCY1B1/GUCY1A2/ADCY6/GNG10	-0.237457815047702
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	31/2614	116/9376	0.958552093501834	GLS/GNG4/GNAI3/ADCY3/PRKCA/SLC38A2/TRPC1/GNAI1/GNB2/PPP3CC/MAPK1/PLCB3/HOMER3/GRIA4/PPP3R1/PPP3CB/GNG5/CACNA1C/CACNA1D/GNG12/PLD1/HOMER1/ITPR3/GRIK2/DLG4/GRM7/PLA2G4A/PLA2G4C/LZTS3/ADCY6/GNG10	-0.279271712053534
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/2614	23/9376	0.935697415255647	GLS/MDH1/GLUD1/ATP1A1/GLUD2/SLC9A3	-0.191963088137539
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	57/2614	212/9376	0.964386251100749	PRKD3/PDGFRA/FGF2/ACTG1/AKT1/CSF1/VEGFC/CTNNB1/GNAI3/PIK3CA/ADCY3/PRKCA/CDC42/ID1/ENAH/MAP2K3/KITLG/PFN2/FGF7/GNAI1/P2RY1/VEGFB/RAP1B/MAPK1/PLCB3/MAP2K2/RALB/PDGFRB/EFNA4/FGFR1/RAF1/NRAS/MAP2K1/KRAS/PRKD1/EFNA5/PIK3R3/AKT3/BRAF/EPHA2/BCAR1/RAP1A/CALM2/ANGPT1/PFN1/PARD3/RRAS/CRKL/RALA/HGF/MAPK12/MAPK14/THBS1/PDGFC/ADCY6/NGF/PARD6G	-0.326094841780125
Organismal Systems	Digestive system	hsa04978	Mineral absorption	16/2614	61/9376	0.940810515885459	MT1X/HEPH/CYBRD1/SLC8A1/MT1E/MT2A/SLC11A2/TRPM7/ATP1A1/SLC30A1/MT1M/STEAP2/CLCN2/MT1A/STEAP1/SLC9A3	-0.28834929189858
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	12/2614	46/9376	0.935697415255647	CPOX/HEPH/FXN/ALAS1/HMBS/ALAD/COX10/EARS2/COX15/HCCS/BLVRA/FECH	-0.271811214460539
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	26/2614	99/9376	0.941998407950971	BDKRB1/PPP1CB/PPP1CC/MAPK10/PIK3CA/ADCY3/BDKRB2/PRKCA/MAP2K3/HTR2B/CAMK2D/MAPK8/PLCB3/MAPK9/PRKCD/IL1R1/PIK3R3/CALM2/ITPR3/CYP2J2/PLA2G4A/PLA2G4C/MAPK12/MAPK14/ADCY6/NGF	-0.360707007927856
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/2614	16/9376	0.896710022953328	GLA/HEXA/A4GALT/B3GALT5	-0.257087578972745
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2614	12/9376	0.896710022953328	CD46/NPC1/NCAM2	-0.22259681604608
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/2614	28/9376	0.896710022953328	PTS/GCH1/MOCS2/CBR1/GGH/QDPR/PCBD1	-0.34031311896256
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/2614	104/9376	0.931198869989995	ETNK1/CHPT1/LPCAT4/PLA2G2A/CRLS1/LPGAT1/PGS1/SELENOI/PLPP5/LPCAT2/SGMS2/LYPLA2/LYPLA1/PTDSS2/LPCAT3/GPD2/GNPAT/PLD1/PNPLA7/CHKA/AGPAT5/LPIN3/GPAM/PLA2G4A/MBOAT2/PLA2G4C/CDS2	-0.438658325099976
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/2614	32/9376	0.896710022953328	PFKM/PGM2/GLA/UGP2/GLB1/PGM1/B4GALT1/GALE	-0.363887889217088
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/2614	52/9376	0.896710022953328	STARD3NL/MYLIP/VAPA/VDAC3/VDAC2/NPC1/ABCA1/LRP1/VDAC1/LIPA/ANGPTL4/SOAT2/LDLRAP1	-0.464365094250722
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	40/2614	154/9376	0.931646777094367	CACNA2D1/AKT1/PPP1CB/PPP1CC/GNAI3/ADCY3/PRKCA/ATP2A2/CACNB2/ATF2/CAMK2D/GNAI1/SLC8A1/MAPK1/BCL2/PPP2CB/PLCB3/CREB5/ATF6B/CACNA2D3/ATP1A1/PPP2R3A/CACNA1C/CACNA1D/TPM4/AKT3/PPP2R5C/PPP2R2A/CALM2/CREB3L4/PPP2R5A/CACNB4/PPP2CA/AGTR1/MAPK12/MAPK14/PPP2R3B/PPP2R5B/ADCY6/POPDC3	-0.531750179014126
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/2614	17/9376	0.843962374544309	SCP2/CYP7B1/HSD17B4/CYP39A1	-0.400350076985324
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/2614	17/9376	0.843962374544309	GLUD1/CA5B/GLUD2/CPS1	-0.400350076985324
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/2614	17/9376	0.843962374544309	LAMP2/LAMP1/PCDH9/NRP2	-0.400350076985324
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	23/2614	91/9376	0.906563979249519	NFKBIA/AKT1/NFKBIE/SOS2/PIK3CA/BCL10/NFKB1/PPP3CC/MAPK1/NFATC1/MAP2K2/PPP3R1/RAF1/MALT1/GSK3B/NRAS/PPP3CB/MAP2K1/KRAS/PIK3R3/AKT3/CHUK/IFITM1	-0.556858589717
Organismal Systems	Endocrine system	hsa04924	Renin secretion	17/2614	69/9376	0.883714225519222	GNAI3/GNAI1/PPP3CC/PLCB3/NPR1/PDE1A/PPP3R1/PPP3CB/CACNA1C/CACNA1D/CALM2/ITPR3/AGTR1/GUCY1B1/GUCY1A2/ADCY6/PDE3A	-0.6027637480507
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	34/2614	134/9376	0.910093754639199	AVPR1A/CALCRL/PPP1CB/PPP1CC/ADCY3/PLA2G2A/PRKCA/PPP1R12B/ARHGEF11/MAPK1/PRKG1/PPP1R14A/PLCB3/NPR1/MAP2K2/RAF1/GNA12/PRKCD/MAP2K1/CACNA1C/CACNA1D/ARHGEF1/BRAF/CALM2/ITPR3/ARHGEF12/ACTA2/AGTR1/PLA2G4A/GNA13/PLA2G4C/GUCY1B1/GUCY1A2/ADCY6	-0.651718613437512
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/2614	26/9376	0.827732328879995	SLC19A2/LMBRD1/ABCD4/SLC19A1/MMACHC/CUBN	-0.546871760444176
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	56/2614	217/9376	0.925636152726016	MYC/MGST1/FGF2/AR/PTGES3/AKT1/KPNA2/KLF4/MGST3/GNAI3/SOS2/PIK3CA/ADCY3/PRKCA/ATF2/GSTO1/FGF7/GNAI1/NFKB1/MAPK1/BCL2/CREB5/GSTM3/MAP2K2/RAF1/HSP90AB1/ATF6B/NRAS/MAP2K1/PGR/KPNA4/ESR1/CACNA1C/BCL6/JAG1/KRAS/CACNA1D/STAT3/GSTA4/PIK3R3/RB1/GSTM2/AKT3/CDC6/GSTT2B/CYP2B6/ARNT/DLL1/HSP90AA1/EPHX2/GSTM5/EPHX1/CREB3L4/KPNA5/STAT5B/ADCY6	-0.689078237591339
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	22/2614	89/9376	0.886634629436999	GLS/GNG4/GABRE/GNAI3/ADCY3/GABBR1/PRKCA/SLC38A2/GNAI1/GNB2/NSF/GABRA2/GABARAPL2/GNG5/CACNA1C/CACNA1D/GNG12/PLCL1/SLC38A5/SLC6A12/ADCY6/GNG10	-0.668095488574833
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/2614	93/9376	0.887067979695766	IFNGR1/IFNGR2/NFKBIA/NFKBIE/MAML2/MAPK10/NFKB1/PPP3CC/MAPK1/MAPK8/NFATC1/PPP3R1/STAT1/PPP3CB/MAPK9/JAG1/HLA-DOB/MAML1/CHUK/DLL1/MAPK12/STAT5B/MAPK14	-0.680479808584495
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	29/2614	116/9376	0.896710022953328	VCAM1/ACTG1/MYL12B/CTNNB1/GNAI3/PIK3CA/MMP2/CXCL12/PRKCA/CDC42/CLDN20/GNAI1/JAM3/RAP1B/ACTN1/PTK2/CLDN10/MYL12A/VCL/CLDN23/PIK3R3/CLDN12/BCAR1/RAP1A/ARHGAP5/PTPN11/MAPK12/MAPK14/OCLN	-0.695957194582803
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	26/2614	105/9376	0.88816992749663	LAMA2/CACNA2D1/ACTG1/ADCY3/ITGAV/SGCB/ATP2A2/CACNB2/ITGB5/SSPN/SLC8A1/LAMA1/SNTB2/CACNA2D3/SNTB1/ITGA6/CACNA1C/CACNA1D/TPM4/SGCE/CACNB4/ITGA5/ADCY6/TGFB3/TNF/LMNA	-0.716458124851017
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	15/2614	63/9376	0.854009545669836	PTGES3/GGT5/PLA2G2A/PTGR1/CBR1/LTA4H/PTGIS/CYP2B6/EPHX2/CBR3/CYP2U1/CYP2J2/PLA2G4A/PLA2G4C/ALOX15B	-0.722854318556326
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/2614	75/9376	0.860841622035195	IDH3A/RPE/RPIA/PFKM/BCAT1/ACO1/TKT/PRPS2/MAT2A/ALDH18A1/SHMT2/GOT1/PGAM1/TALDO1/PRPS1/PSPH/PYCR2/CPS1	-0.752273934214212
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	18/2614	75/9376	0.860841622035195	HSPA5/ADCY3/PRKCA/ATF2/TTF2/GPX8/PLCB3/CREB5/GSR/PDIA4/CANX/ATF6B/ATP1A1/ITPR3/CREB3L4/TG/ADCY6/PAX8	-0.752273934214212
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/2614	23/9376	0.779747846046372	GLS/GLUD1/GOT1/GLUD2/CPS1	-0.657520748349016
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/2614	23/9376	0.779747846046372	B3GALNT2/POMGNT1/B4GALT3/FUT4/B4GALT1	-0.657520748349016
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	19/2614	79/9376	0.86265774360067	MGST1/ADH5/MGST3/ADH1B/GSTO1/CYP2A7/GSTK1/CBR1/GSTM3/CYP2A13/GSTA4/GSTM2/GSTT2B/ADH1C/CYP2B6/GSTM5/EPHX1/CBR3/AKR1C1	-0.762161759705065
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	21/2614	87/9376	0.865788987679076	CACNA2D1/COX7A2L/UQCRC2/ATP2A2/CACNB2/UQCRFS1/SLC8A1/UQCRH/ASPH/CACNA2D3/ATP1A1/CACNA1C/CACNA1D/TPM4/CACNB4/CYC1/COX6C/COX8A/COX6A1/COX5A/COX7B	-0.781923280304659
NA	NA	hsa03272	Virion - Hepatitis viruses	11/2614	48/9376	0.821984187707217	CLDN20/LAMP2/PDCD6IP/TSG101/CHMP7/CLDN10/CLDN23/LAMP1/CLDN12/CHMP1B/OCLN	-0.768751147258551
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/2614	44/9376	0.815190929957571	DYNLL1/ADCY3/DCTN6/DYNC2LI1/DYNC2H1/CREB5/NSF/STX4/CREB3L4/ADCY6	-0.763946774294077
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	28/2614	115/9376	0.873317587571937	DUSP1/GNG4/CASP3/GNAI3/PRKCA/TRPC1/HTR2B/GNAI1/GNB2/MAPK1/PLCB3/RAF1/NRAS/GNG5/MAP2K1/CACNA1C/KCND2/KRAS/CACNA1D/GNG12/BRAF/ITPR3/CYP2J2/PLA2G4A/PLA2G4C/ALOX15B/MAOB/GNG10	-0.849839963432618
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	17/2614	73/9376	0.835291528230497	MGST1/ADH5/MGST3/AOX1/ADH1B/GSTO1/CYP2A7/GSTK1/GSTM3/GSTA4/GSTM2/GSTT2B/ADH1C/CYP2B6/GSTM5/MAOB/FMO4	-0.878348176151324
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/2614	37/9376	0.7755329928245	VCAM1/FAS/PRKCA/IL6/MYD88/PLCB3/THOP1/TNF	-0.850558202416474
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	32/2614	133/9376	0.862999119834782	FAS/IFNGR1/IFNGR2/CASP3/SOS2/PIK3CA/PRKCA/PPP3CC/MAPK1/SHC3/BID/NFATC1/MAP2K2/PPP3R1/RAF1/NRAS/PPP3CB/MAP2K1/FYN/HLA-B/KRAS/PIK3R3/BRAF/TNFRSF10B/MICA/IFNAR2/PTPN11/KLRC2/ULBP2/SHC2/KLRC1/TNF	-0.98933539719159
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/2614	98/9376	0.841809409303124	PRKD3/ADCY3/PRKCA/ATF2/CAMK2D/PLCB3/CREB5/NPR1/ATF6B/ATP1A1/NR4A1/CACNA1H/CACNA1C/CACNA1G/CACNA1D/PRKD1/CAMK1/CALM2/ITPR3/CREB3L4/AGTR1/ADCY6/POMC	-0.978740023214468
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2614	16/9376	0.672532517214996	AOC3/GOT1/MAOB	-0.815062842965443
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/2614	38/9376	0.755124229855434	PIK3CA/PRKCA/MAPK1/ATP1A1/KRAS/PIK3R3/PDPK1/IRS1	-0.940397627957681
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/2614	115/9376	0.842127673730082	GNG4/AKT1/GNAI3/PIK3CA/ADCY3/PRKCA/CAMK2D/GNAI1/GNB2/MAPK1/BCL2/PLCB3/CREB5/NRAS/GNG5/MAP2K1/FYN/CACNA1C/KRAS/CACNA1D/PIK3R3/GNG12/AKT3/ITPR3/CREB3L4/ADCY6/GNG10	-1.05907528450673
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/2614	51/9376	0.773632176665617	CHPT1/LPCAT4/PLA2G2A/SELENOI/LPCAT2/AGPS/PLD1/PAFAH1B1/PLA2G4A/PLA2G4C/PLA2G7	-1.00780430521427
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/2614	44/9376	0.733671836961814	FAS/HLA-F/HSPD1/IL1A/HLA-B/HLA-DOB/PTPRN2/PTPRN/TNF	-1.10092292012496
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/2614	36/9376	0.6974411289637	PGM2/ENPP1/GBE1/PYGL/UGP2/PGM1/GYG1	-1.13080716048182
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	46/2614	193/9376	0.854894529654986	GNG4/NFKBIA/AKT1/CXCL1/GNAI3/SOS2/PIK3CA/CXCL8/ADCY3/CXCL12/CDC42/STAT2/GNAI1/NFKB1/GNB2/RAP1B/MAPK1/SHC3/PLCB3/CXCL5/PTK2/RAF1/STAT1/GSK3B/NRAS/PRKCD/GNG5/MAP2K1/KRAS/GRK4/STAT3/PIK3R3/GNG12/AKT3/BRAF/BCAR1/CXCL2/RAP1A/CHUK/CCL26/PARD3/CRKL/STAT5B/SHC2/ADCY6/GNG10	-1.26640026930357
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	15/2614	70/9376	0.768608591102853	MGST1/MGST3/NAT1/GSTO1/CYP2A7/GSTK1/CBR1/GSTM3/CYP2A13/GSTA4/GSTM2/GSTT2B/GSTM5/EPHX1/AKR1C2	-1.20813529710435
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	12/2614	59/9376	0.729526798334911	AKT1/GNAI3/PIK3CA/ADCY3/GNAI1/PRKG1/NPR1/ABHD5/PIK3R3/AKT3/IRS1/ADCY6	-1.29572562170912
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/2614	76/9376	0.755124229855434	SCP2/HMGCS1/PLIN2/DBI/ACSL1/ACADM/ACOX1/ME3/ACSL4/ACSL5/PPARD/PDPK1/ANGPTL4/UBC/PPARG/GK	-1.33263735681049
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	42/2614	183/9376	0.823209201399777	RIOK2/NXT1/AK6/RAN/NOP10/RPP30/WDR36/HEATR1/WDR3/UTP18/UTP14A/UTP6/NOB1/POP5/RPP40/NXF1/BMS1/GAR1/GNL3/RPP25L/RIOK1/EFL1/XPO1/EMG1/POP7/NXT2/GTPBP4/CSNK2A2/CSNK2B/UTP15/NVL/XRN1/NMD3/XRN2/RPP38/POP1/UTP4/IMP3/NOL6/RCL1/REXO2/SBDS	-1.50161092391969
Human Diseases	Substance dependence	hsa05032	Morphine addiction	19/2614	91/9376	0.748900678510472	GNG4/GABRE/GNAI3/ADCY3/GABBR1/PRKCA/GNAI1/GNB2/PDE1A/PDE4B/GABRA2/GNG5/GRK4/PDE8B/GNG12/PDE8A/ADCY6/GNG10/PDE3A	-1.49649795571837
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/2614	66/9376	0.706498805963228	IFNGR1/IFNGR2/IL6/NFKB1/NFATC1/TLR4/STAT1/IL1A/STAT3/HLA-DOB/IL23A/TGFB3/TNF	-1.48767425129004
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/2614	53/9376	0.67676228147421	BDKRB2/PRKCA/DNM1/SLC8A1/PLCB3/CLTA/ATP1A1/ESR1/PTH1R/ADCY6	-1.46717856025666
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/2614	35/9376	0.614886872882282	PFKM/SORD/FPGT/TIGAR/PFKFB3/GMDS	-1.41914412992925
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/2614	79/9376	0.726448626190038	DNM1/ATP6V1G1/CLTA/ATP6V0E1/NSF/ATP6V1C1/ATP6V1H/SNAP25/ATP6V1E2/SLC6A12/ATP6V1D/ATP6V1A/ATP6V1C2/ATP6V0A2/ATP6V0E2/CPLX1	-1.51803532211195
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/2614	49/9376	0.658807363802445	GNAI3/ATF2/GNAI1/NFKB1/CREB5/ATF6B/CREB3L4/DLG4/MAOB	-1.48876979040388
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/2614	26/9376	0.551821552586664	PLA2G2A/ACOX1/PLA2G4A/PLA2G4C	-1.42276339452764
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2614	31/9376	0.57852259545376	ALDH2/ALDH3A2/ALDH9A1/ALDH1B1/RGN	-1.46139069467927
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/2614	45/9376	0.637660460766811	FAS/HLA-F/IL6/IL1A/HLA-B/HLA-DOB/KLRC1/TNF	-1.51481199881302
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	13/2614	68/9376	0.685719429317251	ALDH1A1/ALDH1A3/ADH5/AOX1/ADH1B/RDH11/CYP2A7/HSD17B6/RDH10/RDH12/PNPLA4/ADH1C/CYP2B6	-1.61712893796955
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/2614	65/9376	0.662185863103996	ALDH2/ALDH3A2/GLA/PLPP5/ALDH9A1/AGPAT5/LPIN3/AGK/GPAM/MBOAT2/ALDH1B1/GK	-1.69917136911336
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/2614	38/9376	0.566343172391576	TAP1/TAP2/DCLRE1C/ADA/RFX5/RFXAP	-1.66537445411549
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/2614	30/9376	0.478245345575108	PLA2G2A/CYP2J2/PLA2G4A/PLA2G4C	-1.77956935174213
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	11/2614	66/9376	0.597806681968885	COMT/HSD17B7/CYP7B1/HSD17B6/SRD5A3/SRD5A1/AKR1C1/AKR1C2/LRTOMT/STS/HSD17B1	-2.03860377890263
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/2614	52/9376	0.551821552586664	HSD17B7/ADCY3/ACOT2/CYP2J2/PLA2G4A/PLA2G4C/HSD17B1/ADCY6	-2.01489469670612
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/2614	48/9376	0.523080846722775	AKT1/PIK3CA/PLCB3/ATP1A1/CACNA1D/PIK3R3/AKT3	-2.05954820254082
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/2614	86/9376	0.625611643920927	ADCY3/PRKCA/ATF2/CAMK2D/PLCB3/CREB5/ATF6B/ATP1A1/RIMS2/CACNA1C/CACNA1D/SNAP25/ITPR3/CREB3L4/ADCY6	-2.16852557485113
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	32/2614	160/9376	0.717368018362663	VCAM1/SDC4/HLA-F/VCAN/ITGAV/SDC2/PTPRM/CNTNAP1/CLDN20/JAM3/CD276/NEGR1/NLGN1/NECTIN3/CNTN1/CLDN10/ITGA6/HLA-B/NEO1/HLA-DOB/CLDN23/CLDN12/NRXN2/NRXN3/SLITRK4/CDH2/CDH3/NCAM2/OCLN/NECTIN2/CDH15/CXADR	-2.24187249327815
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/2614	100/9376	0.645631216526396	MME/CSF1/CD44/KITLG/CSF3/IL6/IL1A/ITGA6/CD55/IL1R1/HLA-DOB/EPOR/IL11RA/CD1D/ITGA5/CD38/IL11/TNF	-2.21501123961755
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/2614	39/9376	0.45985129382222	FAS/HLA-F/HLA-B/HLA-DOB/TNF	-2.10156492204038
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	54/2614	254/9376	0.762556554952437	AVPR1A/PDGFRA/FGF2/BDKRB1/VEGFC/SLC25A5/ADCY3/BDKRB2/PRKCA/ATP2A2/HTR2B/CAMK2D/FGF7/VEGFB/SLC8A1/PPP3CC/VDAC3/VDAC2/STIM2/NFATC1/PLCB3/PDE1A/PDGFRB/PPIF/PPP3R1/MCU/FGFR1/PHKG1/ASPH/PPP3CB/VDAC1/CACNA1H/CACNA1C/CACNA1G/CACNA1D/STIM1/GNAL/ITPKA/ERBB2/ITPKC/ORAI3/CAMK1/CALM2/MST1/ITPR3/EDNRB/PHKA2/AGTR1/HGF/SPHK1/CD38/PDGFC/NGF/OXTR	-2.38524423991828
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/2614	76/9376	0.566343172391576	ACTG1/GNAI3/ADCY3/PRKCA/CAMK2D/GNAI1/PLCB3/ATP1A1/CALM2/ITPR3/SLC26A7/ADCY6	-2.36000192328435
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/2614	100/9376	0.609762815608263	ACKR3/TNFRSF1A/CSF1/CXCL1/CXCL8/CXCL12/IL6/CXCL5/TNFRSF10B/CXCL2/CCL26/TNFSF14/IL6ST/ACKR4/IL10RB/IL19/TNF	-2.43920963091487
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	46/2614	226/9376	0.730064797448727	NFKBIA/AKT1/PPP1CB/PPP1CC/MAPK10/GNAI3/PIK3CA/ADCY3/GABBR1/ATP2A2/CAMK2D/GNAI1/NFKB1/RAP1B/MAPK1/MAPK8/NFATC1/CREB5/NPR1/MAP2K2/PDE4B/GRIA4/RAF1/ATP1A1/MAPK9/HHIP/MAP2K1/CACNA1C/CACNA1D/ACOX1/PIK3R3/AKT3/BRAF/GLI1/ABCC4/PLD1/RAP1A/CALM2/CREB3L4/RRAS/GLI3/ADCY6/PDE3A/OXTR/POMC/POPDC3	-2.55390091804014
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/2614	102/9376	0.597806681968885	RAB27B/ADCY3/PLA2G2A/CPB1/PRKCA/ATP2A2/TRPC1/BST1/RAP1B/PLCB3/ATP1A1/RAB8A/SLC12A2/RAP1A/ITPR3/CD38/ADCY6	-2.53923115344447
Organismal Systems	Sensory system	hsa04742	Taste transduction	13/2614	86/9376	0.542196758064803	GABBR1/P2RY1/SCN2A/PLCB3/PDE1A/GABRA2/CACNA1C/TAS2R14/TAS2R1/ITPR3/ADCY6/TAS2R31/TAS2R30	-2.65167979256426
Cellular Processes	Cell motility	hsa04814	Motor proteins	37/2614	194/9376	0.6840880587479	ACTG1/MYL12B/DYNLT3/ACTR10/DYNLL1/CAPZA2/TUBA3D/DYNLT1/MYO1B/DCTN6/TUBE1/DYNC2LI1/DYNC2H1/TUBB2A/KIF2A/MYL12A/ACTR1B/CAPZA1/DNAH11/CAPZB/TPM4/TUBG1/DNAH14/DNAL4/TUBA1A/KIF9/TUBB6/TUBB2B/MYO1E/ACTA2/KIF5A/MYO6/KIF27/STARD9/MYO16/DNAH7/KIFC3	-2.76438870362219
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/2614	93/9376	0.539954422423509	PRH1/ADCY3/PRKCA/BST1/PRKG1/PLCB3/ATP1A1/SLC12A2/CALM2/ITPR3/GUCY1B1/GUCY1A2/CD38/ADCY6	-2.77203689198196
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/2614	36/9376	0.298903340984443	RPE/SORD/UGP2	-2.62033342301028
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/2614	43/9376	0.333659543424494	PLA2G2A/ABCA1/ACAT2/ACAT1	-2.72283060539998
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/2614	50/9376	0.358684009181331	IL15RA/IL15/CXCL12/IL6/HLA-DOB	-2.8268984787762
Human Diseases	Immune disease	hsa05310	Asthma	2/2614	32/9376	0.224177505738332	HLA-DOB/TNF	-2.73320236789724
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2614	41/9376	0.26245171403512	GABRE/GRIA4/GABRA2	-2.9425650466611
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/2614	54/9376	0.332114823316047	FAS/HLA-F/HLA-B/HLA-DOB/TG	-3.06016597375048
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/2614	99/9376	0.470999203975486	KRT10/CFD/CFI/CFH/KRT23/C3/C1S/C4B/HLA-DOB/FGG/MASP1/KRT34/C1R	-3.28981132387126
NA	NA	hsa04081	Hormone signaling	38/2614	219/9376	0.622374079858018	AVPR1A/GNG4/GNAI3/PIK3CA/ADCY3/ITGAV/HEPH/ADRA2C/GNAI1/GNB2/PRKG1/PLCB3/NPR1/STK11/SMAD4/GNA12/ADIPOR1/GNG5/ESR1/STAT3/PIK3R3/GNG12/BMPR1A/EPOR/ACVR1/PTH1R/ADRA2A/AGTR1/IRS1/GHR/GNA13/STAT5B/SMAD9/SLC16A2/ADCY6/GNG10/OXTR/POMC	-3.51566992211429
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/2614	29/9376	0.123684141097011	CALM2	-2.93849120713225
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	60/2614	323/9376	0.66628608516656	MYC/PLAU/VIM/PDGFRA/GLS/PTEN/CCND2/SOCS1/CASP3/PIM1/CDKN1B/SOS2/PIK3CA/MCL1/CD44/PRKCA/MDM4/MMP16/ABL1/UBE2I/SIRT1/HDAC1/NFKB1/MAPK1/BCL2/MAP2K2/ATM/RECK/PDGFRB/BCL2L2/HOXD10/EFNA4/DDIT4/CCNG1/RAF1/MDM2/NRAS/MAP2K1/KRAS/STAT3/CDC25B/EFNA5/PIK3R3/ERBB2/MAPK7/FSCN1/SOX4/TP53/SPRY2/RASSF1/BMI1/IRS1/CRKL/TNC/ZEB2/THBS1/E2F3/ITGA5/BAK1/MARCKS	-3.79472373193549
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/2614	195/9376	0.570215604339552	ACTG1/AKT1/SLC25A5/PIK3CA/HAT1/PRKCA/HDAC8/HDAC1/HDAC3/NFKB1/MAPK1/VDAC3/VDAC2/PLCB3/MAP2K2/TLR4/PPIF/RAF1/CASP1/VDAC1/MAP2K1/CASP4/C3/MAP3K7/PIK3R3/FGG/AKT3/FGB/HDAC9/MAPK12/MAPK14	-3.77071581053919
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	53/2614	298/9376	0.637927935792301	FAS/IL15RA/IFNGR1/TNFRSF12A/BMP2/IFNGR2/ACKR3/TNFRSF1A/IL15/CSF1/CXCL1/CXCL8/CXCL12/TNFSF12/IL13RA2/CSF3/IL6/CLCF1/OSMR/CXCL5/IL1A/ACVR1B/IL1R1/GDF7/TNFRSF10B/BMPR1A/EPOR/LIF/CXCL2/ACVR1/CCL26/CTF1/TNFSF14/RELT/TSLP/IFNAR2/GDF11/IL11RA/IL13RA1/GHR/IL23A/IL6ST/ACKR4/GDF9/IL10RB/NGF/IL17D/EDA/TGFB3/IL11/IL19/TNF/TNFSF9	-3.94919799102322
NA	NA	hsa04382	Cornified envelope formation	35/2614	217/9376	0.57852259545376	COL4A1/KRT10/COL4A5/CLDN20/SPTLC1/KAZN/PPP2CB/COL4A4/COL4A2/ABHD5/S100A16/KRT23/BLMH/UGCG/CLDN10/ITGA6/COL4A3/PPP2R3A/ELOVL4/CLDN23/CLDN12/KDSR/PPP2R5C/PPP2R2A/COL4A6/EPHX2/PPP2R5A/PPP2CA/KRT34/PPP2R3B/PPP2R5B/OCLN/S100A4/SPTLC2/KRT85	-3.90553901870139
Human Diseases	Substance dependence	hsa05034	Alcoholism	29/2614	191/9376	0.544598757395739	GNG4/PPP1CB/PPP1CC/GNAI3/SOS2/HAT1/ATF2/HDAC8/GNAI1/HDAC1/HDAC3/GNB2/MAPK1/SHC3/CREB5/RAF1/ATF6B/NRAS/GNG5/MAP2K1/KRAS/GNG12/BRAF/CALM2/CREB3L4/HDAC9/SHC2/MAOB/GNG10	-3.95341277406435
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/2614	90/9376	0.358684009181331	ADCY3/ABCC3/HMGCR/ATP1A1/ABCC4/EPHX1/ADCY6/SLC9A3/SLC51A	-3.80084212346922
NA	NA	hsa04082	Neuroactive ligand signaling	29/2614	199/9376	0.522705340012995	P2RY14/OGFRL1/GNG4/GABRE/GNAI3/ADCY3/GABBR1/PRKCA/HTR2B/ADRA2C/GNAI1/P2RY1/GNB2/PLCB3/GRIA4/OGFR/GABRA2/GNG5/GNAL/GNG12/SLC17A9/SLC6A12/GRIK2/ADRA2A/GRM7/GLRB/ADCY6/GNG10/POMC	-4.23120039379088
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/2614	143/9376	0.30099357413818	TRIM21/ACTN1/C3/C1S/SSB/C4B/HLA-DOB/SNRPB/C7/SNRPD1/C1R/TNF	-5.23695227003478
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	30/2614	370/9376	0.290824872309188	AVPR1A/S1PR3/P2RY14/BDKRB1/OGFRL1/CALCRL/GABRE/BDKRB2/GABBR1/HTR2B/ADRA2C/PGRMC1/P2RY1/GRIA4/OGFR/GABRA2/S1PR2/C3/GAL/PTH1R/GRIK2/EDNRB/LPAR6/ADRA2A/GRM7/AGTR1/GHR/GLRB/OXTR/POMC	-8.65344888866777
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/2614	449/9376	0.0639080639966737	ADCY3/RGS2/CAMK2D/SLC8A1/PRKG1/PDE1A/GNAL/CALM2	-12.638331823961